Flavonoid derivatives in jiangxiang and preparation method and application thereof
By isolating and preparing flavonoid derivatives and their enantiomers from Dalbergia odorifera, the problem of insufficient targeting of existing anti-inflammatory drugs has been solved, and good anti-inflammatory activity and low cytotoxicity have been achieved in a lipopolysaccharide-induced inflammation model.
CN120718034BActive Publication Date: 2025-11-18JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Patent Information
- Application Number
- CN202511164524.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-08-20
- Publication Date
- 2025-11-18
- Estimated Expiration
- 2045-08-20
AI Technical Summary
Technical Problem
Existing anti-inflammatory drugs have insufficient targeting and significant side effects, making it difficult to meet the long-term treatment needs of patients with chronic inflammatory diseases.
Method used
Two flavonoid derivatives and their enantiomers were isolated and prepared from Dalbergia odorifera. Their chemical structures and absolute configurations were determined by multi-step chromatography and high-performance liquid chromatography, and they were used to prepare anti-inflammatory drugs.
Benefits of technology
Flavonoid derivatives exhibited good anti-inflammatory activity and low cytotoxicity in a lipopolysaccharide-induced inflammation model, providing a new direction for anti-inflammatory drugs.
✦ Generated by Eureka AI based on patent content.
Abstract
The application belongs to the technical field of natural medicine chemistry, and discloses flavone derivatives in Jinyunhuang, and a preparation method and application thereof.The flavone derivatives are separated from Jinyunhuang of the plant Dalbergia hupeana, and the heartwood of Jinyunhuang is extracted and concentrated to obtain extractum, the extractum is separated by silica gel column chromatography, gel column chromatography, and semi-preparative high performance liquid chromatography, and the flavone derivatives can be obtained.The application establishes an inflammation model by inducing RAW 264.7 cells with lipopolysaccharide (LPS), and confirms that the compound has good anti-inflammatory activity and can be used for preparing anti-inflammatory drugs.
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