Aromatic essential oil composition with refreshing function, fragrance bar and preparation methods of aromatic essential oil composition and fragrance bar

Abstract

The invention discloses an aromatic essential oil composition with a refreshing function, a fragrance rod and preparation methods of the aromatic essential oil composition and the fragrance rod, and the aromatic essential oil composition comprises the following components in percentage by mass: 99.5-99.7% of compound essential oil and 0.3-0.5% of an antioxidant, wherein the compound essential oil is prepared from spearmint essential oil, grapefruit essential oil and tea tree essential oil, and the mass ratio of the spearmint essential oil to the grapefruit essential oil to the tea tree essential oil is (0.5 to 0.8) to (0.19 to 0.49) to (0.01 to 0.05). According to the embodiment of the invention, the golden proportion of spearmint and grapefruit essential oil is innovatively adopted, so that a dual action mechanism is realized: spearmint essential oil activates a peripheral TRPM8 receptor to generate instant cooling feeling, grapefruit essential oil promotes dopamine release to enhance central awakening, tea tree essential oil can inhibit release of central inhibitory neurotransmitters such as GABA (gamma-aminobutyric acid), and tea tree essential oil can promote the release of the central inhibitory neurotransmitters such as GABA (gamma-aminobutyric acid); meanwhile, the herbal cool smell can instantly stimulate nasal mucosa, trigger olfactory awakening reaction and keep the cerebral cortex in a waking state, and the refreshing effect is remarkably better than that of single essential oil through the synergistic effect of the three components.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of aromatherapy products, in particular to an aromatic essential oil formula with refreshing function, a fragrance stick and preparation methods of the two. BACKGROUND

[0002] With the acceleration of people's life pace and the increase of work pressure, the brain is in a high tension state for a long time, and the phenomenon of drowsiness and dozing off often occurs, which seriously affects work. In recent years, the aromatherapy (aromatherapy) of using spices to cheer up and stabilize emotions has gradually become popular. Aromatherapy has a calming, refreshing and exciting effect on the human brain, which has been confirmed by experimental methods such as brain wave measurement. Aromatherapy is also widely used in clinical practice around the world. Modern aromatherapy mostly uses perfumes, snuff and other forms. The volatile components in them are absorbed through the nasal mucosa to produce olfactory sensation, and enter the human circulation through lung gas exchange, which stimulates the central nervous system to calm or excite.

[0003] However, the current aromatherapy has the following technical problems: first, the single formula has limited effect. The single essential oil component (such as peppermint, rosemary, etc.) has a single mechanism of action, resulting in a short duration of refreshing effect (usually <1 hour) and poor refreshing effect. Second, the synergistic effect is missing. The simple mixed essential oil formula lacks scientific proportioning basis and cannot exert the synergistic effect of the components. Third, the neural mechanism is not clear. Most products lack empirical research on the influence of central neurotransmitters (such as 5-HT and DA). In addition, the application method is limited. The traditional essential oil use method (such as direct rubbing) has the risk of skin irritation. Finally, the effect evaluation is subjective and lacks an objective animal behavior and neurobiochemical index evaluation system.

[0004] Therefore, it is an urgent need to develop a refreshing product that addresses the problems of single effect, strong irritation and short duration of existing refreshing products. SUMMARY

[0005] In order to overcome the technical defects of the prior art, the present application provides an aromatic essential oil formula with refreshing function, a fragrance stick and preparation methods of the two, which solves the problems of single effect, strong irritation and short duration of existing refreshing products.

[0006] In order to solve the above problems, the present application proposes the following technical solutions:

[0007] In a first aspect, an aromatic essential oil formula with refreshing function is provided, which comprises, by mass percentage: 99.5-99.7% of a composite essential oil, and 0.3-0.5% of an antioxidant.

[0008] The composite essential oil comprises spearmint essential oil, grapefruit essential oil and tea tree essential oil, and the mass ratio of the spearmint essential oil, the grapefruit essential oil and the tea tree essential oil is (0.5-0.8):(0.19-0.49):(0.01-0.05).

[0009] Further, the antioxidant is dibutyl hydroxytoluene.

[0010] Further, the mass ratio of the spearmint essential oil, the grapefruit essential oil and the tea tree essential oil is 0.77:0.23:0.01.

[0011] In a second aspect, the present application further provides a preparation method of the fragrance stick, comprising the following steps:

[0012] S1, uniformly mixing and stirring the fragrance essential oil composition of any one of the first aspect to completely dissolve, to obtain a fragrance essential oil;

[0013] S2, immersing the absorbable stick in the fragrance essential oil, and allowing the stick to absorb the fragrance essential oil under the condition of negative pressure;

[0014] S3, after the stick absorbs the fragrance essential oil, draining the fragrance and airing until the surface is dry, to obtain the fragrance stick;

[0015] S4, then packaging the stick by using vacuum sealing packaging.

[0016] Further, the stick is a stick made of porous carbon material.

[0017] Further, the stick is a cotton stick.

[0018] Further, in step S2, at least one stick is immersed in a barrel containing the fragrance essential oil, the fragrance essential oil completely immerses all the sticks, then the barrel is placed in a negative pressure vacuum machine with the opening, the hatch of the negative pressure vacuum machine is closed, and the negative pressure parameter is set to-80-900 kPa, and the pressure is maintained for one hour, so that the process of the stick absorbing the fragrance essential oil is carried out under the condition of negative pressure.

[0019] Further, in step S3, after the stick absorbs the fragrance essential oil, the stick is placed in a room temperature environment for flat airing; after the stick is dried, the surface of the stick is wiped clean with a clean and dry towel.

[0020] Further, the time between the drying of the stick and the vacuum sealing packaging is controlled within 2 hours.

[0021] In a third aspect, the present application further provides a fragrance stick, which is prepared by the preparation method of any one of the second aspect.

[0022] Compared with the prior art, the present application has the following beneficial effects:

[0023] 1. The present invention achieves multiple mechanisms of action by innovatively adopting the golden ratio of spearmint, grapefruit essential oil and tea tree essential oil: spearmint essential oil activates peripheral TRPM8 receptors to produce an immediate cooling sensation, grapefruit essential oil promotes dopamine release to enhance central arousal, and tea tree essential oil can inhibit the release of central inhibitory neurotransmitters such as GABA, reducing neural inhibitory signals. At the same time, its herbal and refreshing scent can instantly stimulate the nasal mucosa, triggering the "olfactory awakening response" and keeping the cerebral cortex awake. The synergistic effect of the three makes the refreshing effect significantly better than that of a single essential oil. It can not only quickly stimulate peripheral nerves to produce a cooling sensation, but also promote the release of central dopamine and inhibit the release of GABA, achieving a multi-effect refreshing effect.

[0024] 2. Compared with chemically synthesized invigorating agents, the fragrance essential oil prepared by this aromatic essential oil formula uses pure natural plant essential oil. The container can be placed in the air outlet of the air conditioner or the cup holder. It can be absorbed by people through natural volatilization, and can continuously release the invigorating aroma while driving or working, helping to stay awake and focused. It is a safe, efficient and convenient natural invigorating option. It can also be used in conjunction with a matching aromatherapy machine. Through atomization diffusion, it avoids the side effects of oral medications and is more convenient than traditional application methods.

[0025] 3. The fragrance stick provided in the present invention can be placed in the air outlet of the air conditioner or the cup holder. It can be absorbed by people through natural evaporation, and can continuously release refreshing aroma while driving or working, helping to stay awake and focused. It is a safe, efficient and convenient natural refreshing option; it can also be used in conjunction with a matching aromatherapy machine to accelerate the diffusion of the fragrance essential oil by heating and evaporation.

[0026] Additional aspects and advantages of the present invention will be set forth in part in the following description, will become apparent from the following description, or may be learned by practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 Schematic diagram of the test results of the movement distance of mice in the open field test in Example 1;

[0028] Figure 2 Schematic diagram of the test results of 5-HT concentration in mice in the open field test in Example 1;

[0029] Figure 3 Schematic diagram of the test results of dopamine concentration in mice in the open field test in Example 1. DETAILED DESCRIPTION

[0030] The technical solutions in the embodiments will be described clearly and completely below with reference to the embodiments of the present application. Obviously, the embodiments described below are only a part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all the other embodiments obtained by a person of ordinary skill in the art without creative work fall within the protection scope of the present application.

[0031] It should be understood that the terms "comprising" and "including" as used in the specification and the appended claims indicate the presence of the described features, integers, steps, operations, elements, and / or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and / or groups thereof.

[0032] It should also be understood that the terms used in the specification of the embodiments of the present application are only for the purpose of describing the specific embodiments and are not intended to limit the embodiments of the present application. As used in the specification of the embodiments of the present application and the appended claims, the singular forms "a", "an" and "the" are intended to include the plural forms unless the context clearly indicates otherwise.

[0033] The embodiments of the present application provide a fragrance essential oil composition with refreshing function, which comprises, in percentage by mass, 99.5-99.7% of compound essential oil and 0.3-0.5% of antioxidant, wherein the compound essential oil and the antioxidant are mixed and fully stirred until completely dissolved to ensure no visible particles, so as to obtain the fragrance essential oil with refreshing function.

[0034] It can be understood that the compound essential oil (or Chinese medicine essential oil) in the embodiments refers to a mixture of multiple essential oils.

[0035] Specifically, the compound essential oil comprises spearmint essential oil, grapefruit essential oil and tea tree essential oil, and the mass ratio of the spearmint essential oil, the grapefruit essential oil and the tea tree essential oil is (0.5-0.8):(0.19-0.49):(0.01-0.05).

[0036] The compound essential oil used in this embodiment is rich in carvone, which activates peripheral TRPM8 receptors to produce an instant cooling sensation, and has the effect of refreshing the mind and opening the orifices. Grapefruit essential oil is rich in limonene, which promotes the release of dopamine to enhance central arousal, and can soothe the liver, relieve depression, and invigorate the spirit. Tea tree essential oil can inhibit the release of central inhibitory neurotransmitters such as GABA, reducing neural inhibition signals. At the same time, its herbal and refreshing scent can instantly stimulate the nasal mucosa, triggering an "olfactory surprise response" to keep the cerebral cortex awake. Through scientific proportioning, the synergistic effect of spearmint essential oil, grapefruit essential oil, and tea tree essential oil can quickly stimulate peripheral nerves to produce a cooling sensation, promote the release of central dopamine, and inhibit the release of GABA, achieving a multi-effect refreshing effect. The synergistic mechanism of the three is as follows:

[0037] 1) Odor hierarchy complementarity: the cooling of spearmint, the fruity aroma of grapefruit, and the refreshing of tea tree blend together to form a rich olfactory experience, continuously stimulating the cerebral cortex and avoiding olfactory adaptation caused by a single scent.

[0038] 2) Neural regulation synergy: menthol, limonene, eucalyptol, and other components work together on the nervous system, stimulating nerve excitement through cooling, regulating mood through fruity components, and maintaining attention through tea tree invigorating components, improving mental state from multiple aspects.

[0039] 3) Efficacy stacking: spearmint relieves fatigue, grapefruit boosts mood, and tea tree enhances concentration. The combination of the three can simultaneously act on physical fatigue and mental fatigue, achieving a more comprehensive refreshing effect.

[0040] Preferably, the antioxidant is butylated hydroxytoluene (BHT), which is a highly effective antioxidant widely used in essential oils. Its core function is to effectively prevent oxidation of the fragrance, thereby extending the shelf life of the product.

[0041] As a preferred embodiment, the mass ratio of spearmint essential oil, grapefruit essential oil, and tea tree essential oil is 0.77:0.23:0.01.

[0042] Example 1

[0043] This example will verify the efficacy of the above-mentioned aromatic essential oil formula with a refreshing function, i.e., further testing of the compound essential oil composed of spearmint essential oil, grapefruit essential oil, and tea tree essential oil.

[0044] This experiment uses a random grouping design, with experimental animals divided into 12 groups, including 1 control group and 11 different compound essential oil experimental groups, with 10 mice in each group. The 11 experimental groups are numbered 1 to 11, and the experimental animals receive 20 minutes of aerosolized essential oil inhalation treatment (constant concentration of 2 mg / m 3), and the open field test was performed after the end of inhalation on the 3rd day. The control group was not treated. Eleven experimental groups respectively inhaled compound essential oils with different proportions listed in Table 2.

[0045] Table 2: Composition of compound essential oils in the experimental groups in Example 1

[0046] Group Peppermint essential oil / uL Tea tree essential oil / uL Grapefruit essential oil / uL 1 10 10 980 2 250 740 10 3 350 320 330 4 10 980 10 5 500 10 490 6 490 500 10 7 10 740 250 8 10 490 500 9 980 10 10 10 180 160 660 11 670 160 170

[0047] Open field test

[0048] The spontaneous activity of mice will change to a large extent after being stimulated by rotation, which is manifested as changes in movement time and distance, increase in facial modification behavior, and changes in resting time, etc. The mice were placed in a closed space with a size of 50cm*50cm*40cm, and the behavior and activity process of the mice were recorded by a camera. The behavior test was performed immediately after the end of the inhalation treatment of essential oil on the 3rd day. The animals were given 3 minutes of environmental adaptation time before the test, and the movement distance (m) in 5 minutes was recorded as the main observation index. The test results are shown in Figure 1 .

[0049] Detection of 5-HT and dopamine (DA)

[0050] After the completion of the behavior test in the open field test, the mice were quickly sacrificed, and the brain tissues were taken out after dissection, and the hypothalamus and hippocampus were separated. The concentrations of 5-hydroxytryptamine (5-HT, ng / ml) and dopamine (DA, pg / ml) in the brain tissues of mice in each group were detected by ELISA method. The detection results of the concentration of 5-hydroxytryptamine (5-HT, ng / ml) in the brain of each group of mice are shown in Figure 2 , and the detection results of the concentration of dopamine (DA, pg / ml) in the brain of each group of mice are shown in Figure 3 .

[0051] According to the test results of Figures 1 to 3 , the movement distance of the animals in the experimental group inhaling essential oil is longer than that of the animals in the control group, the concentration of 5-HT in the brain tissue is reduced, and the concentration of DA is increased, which indicates that the compound essential oil has a certain refreshing effect.

[0052] Best fit ratio

[0053] The experimental data described above were statistically analyzed using GraphPad Prism 8.0 software, a better ratio was fitted by computer, and finally the best mass ratio of spearmint essential oil, grapefruit essential oil and tea tree essential oil was 0.77:0.23:0.01. According to the best compound essential oil compatibility ratio, 770 μL of spearmint essential oil, 230 μL of grapefruit essential oil and 10 μL of spearmint essential oil were mixed uniformly to prepare the compound essential oil, and another group (a total of 10 mice) of animal experiments was carried out by inhaling the best compound essential oil ratio, and the same experimental operation was carried out as above, as the best group, that is, the mice in the best group received 20 minutes of aerosol essential oil inhalation treatment (constant concentration 2 mg / m 3 ) every day for 3 consecutive days, and the open field test and 5-HT and dopamine (DA) concentration detection were carried out after the inhalation ended on the 3rd day. The specific process is as above, the running distance test result of the open field test of the best group is shown in Figure 1 , and the 5-HT and dopamine (DA) concentration detection results obtained after the open field test are shown in Figure 2 and Figure 3 .

[0054] The animal experiment was verified by the best compound essential oil ratio obtained by computer fitting, and the test results of Figure 1 show that compared with the control group and other experimental groups, the movement distance of the experimental animals in the best group is farther; from Figure 2 , it can be seen that compared with the control group and other experimental groups, the 5-hydroxytryptamine (5-HT, ng / ml) concentration in the mice of the best group is the lowest; from Figure 3 , it can be seen that compared with the control group, the dopamine (DA) concentration in the mice of the best group is significantly improved, although the dopamine (DA) concentration in some experimental groups is higher than that in the mice of the best group, but the other two experimental data (i.e. movement distance and 5-hydroxytryptamine concentration) are quite different from the effect of the best group. In view of the three data, the experimental results of the mice in the best group are the most ideal state.

[0055] And according to the above experimental verification, the compound essential oil composed of spearmint essential oil, grapefruit essential oil and tea tree essential oil can take effect within 5-8 minutes, and the effect lasts for 2-3 hours, and the user's movement distance is improved by 73.6%, and the dopamine concentration is improved by 62.4%.

[0056] Example 2

[0057] The preparation method of a fragrance stick shown in this embodiment comprises the following steps:

[0058] (1) according to the mass ratio of spearmint essential oil: grapefruit essential oil: tea tree essential oil = (0.5-0.8) : (0.2-0.3) : (0.01-0.1), the essential oils are mixed to prepare the compound essential oil.

[0059] 0.8):(0.19~0.49):0.01 After weighing each component, mix and stir them in a barrel to obtain a composite essential oil. Then, add antioxidant BHT (butylated hydroxytoluene) to the composite essential oil, fully stir until completely dissolved, and ensure that there are no visible particles. Subsequently, stand by for use, and prepare the fragrance essential oil. In terms of mass percentage, the fragrance essential oil comprises 99.5-99.7% of the composite essential oil and 0.3-0.5% of the antioxidant.

[0060] (2) Soak the liquid-absorbable core rod in the fragrance essential oil, and make the core rod absorb the fragrance essential oil under negative pressure. The use of negative pressure technology can improve the efficiency of the core rod absorbing the fragrance.

[0061] Specifically, immerse at least one core rod in a barrel containing the fragrance essential oil, and make the fragrance essential oil completely immerse all the core rods. Then, place the barrel in an open state in a negative pressure vacuum machine, close the hatch of the negative pressure vacuum machine, and set the negative pressure parameter to -80~900 kPa. Run for one hour to make the process of the core rod absorbing the fragrance essential oil under negative pressure.

[0062] Specifically, the liquid level of the fragrance essential oil in the barrel needs to be at a certain distance from the barrel edge to prevent overflow during negative pressure absorption. Preferably, the height difference between the liquid level of the fragrance essential oil and the barrel edge is 5-10 cm.

[0063] In a feasible implementation case, the core rod is a rod made of porous carbon material, which has excellent fragrance storage performance and electrical conductivity, and can be directly used as a resistance heater to form a heating and volatilizing fragrance mode. The porous carbon material is preferably activated carbon or graphene, which has high specific surface area, uniform porosity, and good electrical conductivity.

[0064] In another feasible implementation case, the core rod can also be a cotton swab or other liquid-absorbable rod, which is not specifically limited and enumerated here.

[0065] (3) After the core rod absorbs the fragrance essential oil under negative pressure, drain the water and air dry the surface to obtain a fragrance stick.

[0066] In an implementation case, after the core rod absorbs the fragrance essential oil, place the core rod in a room temperature environment for flat drying, and the drying time is at least 30 min. After drying, wipe the surface of the core rod with a clean and dry towel.

[0067] (4) Then, package the core rod by using vacuum sealing packaging, that is, package the core rod in a vacuum bag and a vacuum box to effectively reduce the loss of fragrance and ensure the concentration and odor of the fragrance.

[0068] Specifically, the time of the fragrance stick exposed to air during the packaging process should be minimized, and the time of the fragrance stick exposed to air at room temperature should not exceed 2 hours, that is, the time between the drying of the core stick and the vacuum sealing packaging should be controlled within 2 hours, and the fragrance stick should be handled gently to avoid scratching the surface of the fragrance stick.

[0069] The technical solutions provided by the embodiments of the present application are described in detail above, and specific examples are applied in this paper to describe the principles and implementation manners of the embodiments of the present application. The above description of the embodiments is only applicable to help understand the principles of the embodiments of the present application; at the same time, for those skilled in the art, according to the embodiments of the present application, the specific implementation manners and application ranges will be changed, and the above description should not be understood as a limitation of the present application.

Claims

1. A formula of aromatic essential oils having a refreshing function, characterized in that: Calculated by mass percentage, the aromatic essential oil formula comprises: 99.5-99.7% of compound essential oil and 0.3-0.5% of antioxidant; The composite essential oil comprises spearmint essential oil, grapefruit essential oil and tea tree essential oil, and the mass ratio of the spearmint essential oil, grapefruit essential oil and tea tree essential oil is (0.5-0.8):(0.19-0.49):(0.01-0.05).

2. The aromatic essential oil prescription according to claim 1, wherein The antioxidant is butylated hydroxytoluene.

3. The aromatic essential oil prescription according to claim 1 or 2, wherein The mass ratio between spearmint essential oil, grapefruit essential oil and tea tree essential oil is 0.77:0.23:0.

01.

4. A method for preparing a fragrance stick, characterized in that: The following steps are involved: S1. Mix and stir the aromatic essential oil formulation according to any one of claims 1 to 3 until it is completely dissolved to obtain aromatic essential oil; S2, immersing the liquid-absorbing core rod in the fragrance essential oil, and allowing the core rod to absorb the fragrance essential oil under negative pressure; S3, after the core stick absorbs the fragrance essential oil, drain the perfume and dry it until the surface is dry to obtain a fragrance stick; S4. Then the core rod is packaged in a vacuum sealed packaging manner.

5. The preparation method according to claim 4, characterized in that The core rod is a rod made of porous carbon material.

6. The preparation method according to claim 4, characterized in that The core rod is a cotton swab.

7. The preparation method according to claim 4, characterized in that In step S2, at least one core rod is immersed in a barrel filled with fragrance essential oil, and the fragrance essential oil completely immerses all the core rods. Then, the barrel is opened and placed in a negative pressure vacuum machine, the hatch of the negative pressure vacuum machine is closed, and the negative pressure parameter is set to -80~900kPa. The pressure is maintained for one hour, so that the process of the core rod absorbing the fragrance essential oil is carried out under negative pressure conditions.

8. The preparation method according to claim 4, characterized in that In step S3, after the core rod has absorbed the essential oil, the core rod is placed at room temperature and laid flat to dry; after the core rod is dried, the surface of the core rod is wiped clean with a clean and dry towel.

9. The preparation method according to claim 4, characterized in that The time between the core rod being dried and the vacuum sealed packaging is controlled within 2 hours.

10. A fragrance stick, characterized in that: The method is described in any one of claims 4 to 9.

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