Solid-phase extraction device based on ion chromatography determination

Abstract

The invention relates to the technical field of solid-phase extraction, and discloses a solid-phase extraction device based on ion chromatography determination, which comprises a cylinder body, a waste liquid tank, a panel arranged on the cylinder body, a sample holder arranged in the cylinder body, a plurality of placing holes arranged at the upper end of the sample holder, and sample tubes arranged in the placing holes, the solid-phase extraction unit is arranged at the upper end of the panel; the solid-phase extraction unit comprises a pressurizing component and a straightening component which are arranged at the upper end of the panel; by arranging the pressurizing component and controlling the pressurizing pump to pressurize above the solid-phase extraction column, an operator can directly control the pressurizing efficiency of the pressurizing pump to control the filtering speed and can directly replace the sample rack and the waste liquid tank, and meanwhile, the arranged straightening component can enable the surface of a solvent in the solid-phase extraction column to be horizontal; and after entering, the high-pressure gas can uniformly act on the solvent.

Description

TECHNICAL FIELD

[0001] The application relates to the technical field of solid phase extraction, and in particular to a solid phase extraction device based on ion chromatography. BACKGROUND

[0002] An ion chromatograph is a powerful tool for analyzing ions and polar compounds in water solvents, in ion chromatography analysis, sample pretreatment usually involves the use of a solid phase extraction device to enrich target ions and reduce the influence of interfering substances. The solid phase extraction column is a column filled with filler with specific chemical properties. The solid phase extraction device is composed of a cylinder, a panel, a waste liquid tank, a solid phase extraction column and a sample tube. In use, the solid phase extraction column is inserted into the mounting hole on the panel, the waste liquid tank is placed inside the cylinder, and then the inside of the cylinder is pumped to negative pressure by a suction pump. First, the solid phase extraction column is activated, loaded and eluted. At this time, the waste liquid flows into the waste liquid tank under the action of negative pressure. Then, the negative pressure is released, the sample holder and the sample tube are placed inside the cylinder, and the inside of the cylinder is brought back to a negative pressure state. At this time, elution is performed, and the target ions enriched in the solid phase extraction column are eluted and flow into the sample tube to complete the treatment.

[0003] The existing solid phase extraction device has the following problems. By bringing the inside of the cylinder to a negative pressure state, the filtration speed is accelerated. However, achieving negative pressure usually requires a special negative pressure pump or negative pressure system, and configuring these devices increases additional costs. In the solid phase extraction operation, the operator needs to release the negative pressure state of the cylinder when replacing the waste liquid tank with the sample tube, and needs to bring the cylinder back to the negative pressure state after the replacement is completed. The operation is complex and further increases the labor cost of the experiment. When negative pressure is used, the operator needs to manually operate the knob to control the communication between the solid phase extraction column and the inside of the cylinder. Since multiple solid phase extraction columns are used in the solid phase extraction device for sample treatment, the operator needs to rotate the knob to open multiple solid phase extraction columns in sequence, and needs to close multiple solid phase extraction columns in sequence after the extraction is completed, further increasing the operation complexity and workload. Therefore, a solid phase extraction device is needed, which uses a pressurizing pump to pressurize instead of negative pressure, so that the operator can directly replace the waste liquid tank with the sample holder, and directly increases the filtration speed through pressurization, without the need for manual rotation of the knob. This effectively improves the extraction efficiency and reduces the operation cost. SUMMARY

[0004] In view of the problems in the prior art that the replacement of the sample holder is more troublesome when the filtration is accelerated by negative pressure, and the operator needs to manually rotate the plug to control the communication between the cylinder and the solid phase extraction column, a solid phase extraction device based on ion chromatography is proposed.

[0005] The application provides a solid phase extraction device based on ion chromatography determination, which aims to: by setting a pressurizing component, by controlling the pressurizing pump to pressurize above the solid phase extraction column, the operator can directly control the pressurizing efficiency of the pressurizing pump to control the filtering speed, and the sample rack and the waste liquid tank can be directly replaced, and the setting of the aligning component can make the solvent surface in the solid phase extraction column be horizontal, the high-pressure gas can uniformly act on the solvent after entering, the solvent can uniformly and quickly flow, the filtering speed can be more accurately controlled, and the operation is simple and convenient.

[0006] The technical scheme of the application is: a solid phase extraction device based on ion chromatography determination, comprising a cylinder body and a waste liquid tank, a panel arranged on the cylinder body, a sample rack arranged in the cylinder body, a plurality of placing holes opened at the upper end of the sample rack, a sample tube arranged in the placing hole, further comprising a solid phase extraction unit arranged at the upper end of the panel, the solid phase extraction unit comprising a pressurizing component and an aligning component arranged at the upper end of the panel.

[0007] The pressurizing component comprises an air inlet box arranged at the upper end of the panel, an air inlet valve arranged on the air inlet box, two air conveying pipes arranged on both sides of the air inlet box, a plurality of mounting boxes arranged at the upper end of the panel, a flow-through box arranged in the mounting box, a plurality of piston cylinders arranged in the mounting box, a plurality of piston plates slidingly arranged in the piston cylinders, a return spring arranged between the piston plate and the inner wall of the piston cylinder, a gas conveying pipe arranged between the piston cylinder and the flow-through box, a pressurizing pipe arranged at the upper end of the piston cylinder, a plurality of extraction holes opened in the panel, and a solid phase extraction column arranged in the extraction hole.

[0008] The waste liquid tank and the sample rack are placed in the cylinder body and below the plurality of extraction holes, the two air conveying pipes are fixedly communicated with both ends of the flow-through box, the plurality of gas conveying pipes are fixedly communicated with the corresponding piston cylinder and the flow-through box, one end of the pressurizing pipe away from the piston cylinder is fixedly communicated with the upper end of the solid phase extraction column, the plurality of placing holes on the sample rack are on the same horizontal plane as the plurality of corresponding extraction holes, and the sidewall of the solid phase extraction column is fixedly communicated with a liquid adding pipe for adding solvent.

[0009] Further, the aligning component comprises a push rod arranged on the sidewall of the piston plate, a square plate arranged at one end of the push rod, a plurality of buffer springs arranged on the sidewall of the square plate, a movable clamping plate arranged at one end of the plurality of buffer springs, a fixed clamping plate arranged on the adjacent mounting box, and a driving assembly arranged in the fixed clamping plate.

[0010] Further, the driving assembly comprises an installation groove formed on the inner wall of the fixed clamping plate, a rotating shaft arranged in the installation groove, a rotating wheel arranged on the rotating shaft, a transmission gear arranged at the two ends of the rotating shaft, a driving gear arranged on the side wall of the installation groove, a rotating rod arranged between the two driving gears, and the two ends of the rotating rod are rotatably penetrated into the two sides of the fixed clamping plate, the two transmission gears are engaged with the corresponding driving gears, and the trigger element is arranged between the rotating rod and the installation box.

[0011] Further, the trigger element comprises a support block arranged on the two sides of the fixed clamping plate, the two sides of the rotating rod are arranged on the support blocks, a control gear is arranged at the two ends of the rotating rod, two slide rails are arranged on the side wall of the installation box, two slide plates are slidably arranged on the two slide rails, a plurality of tooth blocks are arranged on the side wall of the slide plate, two guide rails are arranged on the adjacent side wall of the installation box, a sliding block is slidably arranged on the guide rail, a connecting rod is arranged between the sliding block and the lower end of the corresponding slide plate, a locking rod is arranged on the sliding block, and the slide plate is engaged with the corresponding control gear through the plurality of tooth blocks.

[0012] Further, the surface of the rotating wheel is fixedly sleeved with a rubber ring for increasing friction, and the side edge of the rotating wheel is in the same plane as the surface of the fixed clamping plate.

[0013] Further, the fixed clamping plate and the movable clamping plate are both semicircular rings.

[0014] Further, the inside of the cylinder body is provided with a placing cavity, and the end surface of the sample rack and the waste liquid tank is equal in shape and size to the end surface of the placing cavity.

[0015] Further, the inside bottom end of the solid-phase extraction column is filled with a filler.

[0016] The beneficial effects of the present application are as follows:

[0017] 1. By arranging the pressure pump, the negative pressure is replaced by pressure, so that the operator can directly control the filtering speed by changing the opening and pressure efficiency of the pressure pump, without manually rotating the knob multiple times, and the waste liquid tank and the sample rack can be directly replaced, which is simple and convenient, effectively improves the working efficiency of the solid-phase extraction device, reduces the workload of the operator, and improves the operation speed of the operator and the efficiency and yield of the experiment.

[0018] 2. By arranging the aligning component, the solid-phase extraction column is aligned and fixed before the high-pressure gas enters the solid-phase extraction column, so that the solvent surface of the solid-phase extraction column is in a horizontal state, and the high-pressure gas can uniformly generate a downward thrust on the solvent surface after entering, so that the solvent can uniformly flow through the filler, and the solvent can pass through the solid-phase material more quickly, thereby improving the adsorption and elution efficiency of the analyte, and further improving the enrichment and separation effect of the analyte.

[0019] 3. By setting the driving assembly, only when the solid phase extraction column is inserted between the fixed clamping plate and the movable clamping plate, the piston plate in the piston cylinder will move under the action of high-pressure gas, and when there is no solid phase extraction column inserted, the corresponding piston plate will not move due to the change of high-pressure gas, so no matter how many solid phase extraction columns the operator needs to operate at the same time, only the pressurizing pump needs to be directly opened to pressurize, and the high-pressure gas generated by the pressurizing pump will only flow into the corresponding piston cylinder clamping the solid phase extraction column, effectively improving the flexibility and convenience of the device. BRIEF DESCRIPTION OF DRAWINGS

[0020] Figure 1 It is a first perspective view of the structure of the application.

[0021] Figure 2 It is a second perspective view of the structure of the application.

[0022] Figure 3 It is a perspective view of the application. Figure 2 It is an enlarged structure diagram of A in the application.

[0023] Figure 4 It is a perspective view of the application. Figure 2 It is an enlarged structure diagram of B in the application.

[0024] Figure 5 It is a front view of the application. Figure 3 It is a front view of the application.

[0025] Figure 6 It is a partial sectional view of the structure of the application. Figure 5

[0026] It is a sectional view of the structure of the application. Figure 7

[0027] It is a sectional view of the structure of the application. Figure 8

[0028] It is a sectional view of the structure of the application. Figure 9 Figure 8 It is a sectional view of the structure of the application.

[0029] Figure 10 It is a sectional view of the structure of the application.

[0030] In the figure:

[0031] ​1, cylinder; 2, waste liquid tank; 3, panel; 4, sample holder; 5, sample tube; 6, air inlet box; 7, air inlet valve; 8, air transmission pipe; 9, mounting box; 10, flow-through box; 11, piston cylinder; 12, piston plate; 13, return spring; 14, gas delivery pipe; 15, pressurizing pipe; 16, solid phase extraction column; 17, liquid feeding pipe; 18, push rod; 19, square plate; 20, buffer spring; 21, movable clamping plate; 22, fixed clamping plate; 23, rotating shaft; 24, rotating wheel; 25, transmission gear; 26, drive gear; 27, rotating rod; 28, support block; 29, control gear; 30, slide rail; 31, slide plate; 32, tooth block; 33, guide rail; 34, slide block; 35, connecting rod; 36, locking rod; 37, filler. DETAILED DESCRIPTION

[0032] In order to make the above objectives, features and advantages of the present application more obvious and easy to understand, the specific embodiments of the present application will be described in detail below with reference to the accompanying drawings.

[0033] Example 1, refer to Figures 1-2 , Figures 6-7 and Figure 10For the first embodiment of the present application, a solid phase extraction device based on ion chromatography determination is provided, comprising a cylinder body 1 and a waste liquid tank 2, a panel 3 fixedly installed on the cylinder body 1, a sample rack 4 placed inside the cylinder body 1, a plurality of placing holes opened at the upper end of the sample rack 4, a sample tube 5 placed in the placing hole, further comprising a solid phase extraction unit installed on the upper end of the panel 3, the solid phase extraction unit comprising a pressurizing component and a positioning component installed on the upper end of the panel 3; the pressurizing component comprises a gas inlet box 6 fixedly installed on the upper end of the panel 3, a gas inlet valve 7 fixedly installed on the gas inlet box 6, two gas transmission pipes 8 fixedly communicated on both sides of the gas inlet box 6, a plurality of installation boxes 9 fixedly installed on the upper end of the panel 3, a flow-through box 10 fixedly installed inside the installation box 9, a plurality of piston cylinders 11 fixedly installed inside the installation box 9, a plurality of piston plates 12 slidingly installed inside the plurality of piston cylinders 11, a return spring 13 fixedly installed between the piston plate 12 and the inner wall of the piston cylinder 11, a gas conveying pipe 14 fixedly communicated between the piston cylinder 11 and the flow-through box 10, a pressurizing pipe 15 fixedly communicated on the upper end of the plurality of piston cylinders 11, a plurality of extraction holes opened on the panel 3, a solid phase extraction column 16 placed in the extraction hole; the waste liquid tank 2 and the sample rack 4 are both placed inside the cylinder body 1 and located below the plurality of extraction holes, the two gas transmission pipes 8 are respectively fixedly communicated with both ends of the flow-through box 10, the plurality of gas conveying pipes 14 are all fixedly communicated with the corresponding piston cylinder 11 and the flow-through box 10, the pressurizing pipe 15 away from the piston cylinder 11 is fixedly communicated with the upper end of the solid phase extraction column 16, the plurality of placing holes on the sample rack 4 are on the same horizontal plane as the corresponding plurality of extraction holes, and the sidewall of the solid phase extraction column 16 is fixedly communicated with a liquid adding pipe 17 for adding solvent. A placing cavity is opened inside the cylinder body 1, and the end face shape and size of the sample rack 4 and the waste liquid tank 2 are equal to the end face shape and size of the placing cavity. The inside bottom end of the solid phase extraction column 16 is filled with a filler 37.

[0034] Specifically, the cylinder 1 is placed beside the pressurizing pump (not shown in the figure), and the pressurizing pump is fixedly communicated with the air inlet tank 6 through the pipeline. When the pressurizing pump is started, the pressurizing pump compresses air into the air inlet tank 6, and then the air enters the piston cylinder 11 through the air conveying pipe 8, the flow tank 10 and the gas conveying pipe 14. The placement cavity is opened on the cylinder 1, and the waste liquid tank 2 and the sample rack 4 are placed in the placement cavity. The waste liquid tank 2 is placed in the placement cavity when the operator performs activation, sample loading and elution operation. When the solvent is injected into the solid phase extraction column 16 through the liquid adding pipe 17, the pressurizing pump is started, the high-pressure gas enters the solid phase extraction column 16, and the downward pressure is generated on the solvent in the solid phase extraction column 16, so that the solvent flows into the waste liquid tank 2 through the filler 37. The waste liquid tank 2 is used for collecting waste water during operation, and is convenient for the operator to uniformly process in the later period. The reset spring 13 is used for resetting the piston plate 12. When the high-pressure gas enters the inside of the piston cylinder 11, the piston plate 12 moves in the horizontal direction. When the piston plate 12 moves to the other end of the pressurizing pipe 15, the high-pressure gas enters the solid phase extraction column 16 through the pressurizing pipe 15, and generates pressure on the solvent in the inside, so as to accelerate the filtering speed, and make the analyte separate and enrich in the filler 37. When the operator completes the above operation and starts the elution operation, the waste liquid tank 2 is taken out, and the sample rack 4 with the sample tube 5 is placed in the placement cavity. At this time, the sample solvent is added, and the pressurizing pump is continuously started, so that the high-pressure gas compresses the sample solvent to flow through the filler 37, so that the analyte separated and enriched in the filler 37 flows into the sample tube 5 in the sample rack 4 with the sample solvent, and the sample processing is completed. The filler 37 is the core component of the solid phase extraction column 16, and is also the most important part. The filler 37 is usually a solid material with specific chemical properties, such as adsorbent or resin. The purpose is to selectively adsorb or exclude specific analytes in the sample for pretreatment or enrichment. Common fillers 37 include silica gel, C18 (n-octadecyl), epoxide and the like. The placement cavity is opened in the inside of the cylinder 1, and the end face shape and size of the sample rack 4 and the waste liquid tank 2 are equal to the end face shape and size of the placement cavity. The purpose is that when the sample rack 4 is placed in the placement cavity, the sample tube 5 on the sample rack 4 is located below the corresponding extraction hole, so that the filtered solvent can directly flow into the sample tube 5 without manual adjustment. The pressurizing mode of the pressurizing pump can directly control the pressurizing efficiency of the pressurizing pump to control the filtering speed of the solvent, and manual rotation of the knob is not needed, so that the convenience during operation is effectively improved, and the experimental efficiency is improved.

[0035] The inside of the liquid adding pipe 17 is provided with a one-way valve, so that when the operator injects the sample solvent, it can be injected through the liquid adding pipe 17, and when there is high-pressure gas inside, the high-pressure gas cannot flow out through the liquid adding pipe 17. The port at the upper end of the liquid adding pipe 17 is fixedly connected with a liquid storage pipe (not shown in the figure), which is filled with methanol or other activation solution. A pneumatic pump (not shown in the figure) and a controller (not shown in the figure) are provided on the panel 3. The pneumatic pump is electrically connected with the controller. The exhaust port of the pneumatic pump is connected with the upper end of the liquid storage pipe. During the solid phase extraction process, when a small amount of methanol or other activation solution in the liquid storage pipe is added to the solid phase extraction column 16 through the liquid adding pipe 17 for multiple times, the operator can set the program in advance (i.e. the number of times of adding methanol or activation solution and the volume of single addition of solution) through the controller, so that the controller controls the opening and closing degree or other control parameters of the pneumatic pump to realize the addition of the solution to the solid phase extraction column 16 through pressurization, without manual operation to complete the automatic liquid adding operation. At the same time, the pneumatic pump has the following advantages: the volume of the pressurized gas is accurately controlled to control the volume of the added activation solution, that is, the volume of the pressurized gas is equal to the volume of the activation solution, and the pressure generated by the pneumatic pump is greater than the gas pressure inside the solid phase extraction column 16.

[0036] During use, when performing activation, sample loading and elution operations, the operator places the solid phase extraction column 16 in the extraction hole, places the waste tank 2 in the placing cavity of the cylinder body 1, fixes the air inlet valve 7 on the air inlet box 6 with the pressurizing pump, injects the sample solvent into the solid phase extraction column 16 through the liquid adding pipe 17, and closes the liquid adding pipe 17. Turn on the pressurizing pump, the pressurizing pump injects the compressed gas into the piston cylinder 11 through the gas transmission pipe 8, the flow-through box 10 and the gas conveying pipe 14. As the high-pressure gas in the piston cylinder 11 increases, the piston plate 12 in the piston cylinder 11 moves horizontally. When the piston plate 12 moves to the pressurizing pipe 15, the high-pressure gas is injected into the upper end of the solid phase extraction column 16 through the pressurizing pipe 15. The high-pressure gas generates a downward thrust on the sample solvent in the solid phase extraction column 16, thereby accelerating the filtration of the sample solvent by the filler 37, and enriching and separating the analyte in the filler 37.

[0037] Embodiment 2, refer to Figures 3-8 For the second embodiment of the application, the difference between this embodiment and the first embodiment is that the adjusting component includes a push rod 18 fixedly installed on the side wall of the piston plate 12, a square plate 19 fixedly installed on one end of the push rod 18, a plurality of buffer springs 20 fixedly installed on the side wall of the square plate 19, a movable clamping plate 21 fixedly installed on one end of the plurality of buffer springs 20, and a fixed clamping plate 22 fixedly installed on the adjacent installation box 9. The fixed clamping plate 22 and the movable clamping plate 21 are both semicircular rings.

[0038] Specifically, when the fixed clamping plate 22 and the movable clamping plate 21 are in close contact with each other, the circular ring composed of the two semicircular rings is equal to the outer wall of the solid-phase extraction column 16, so that the solid-phase extraction column 16 can be better fixed and aligned. The function of the alignment part is that before the high-pressure gas promotes the filtration of the sample solvent, the high-pressure gas needs to pass through the sliding of the piston plate 12 in the piston cylinder 11, and at the same time, the piston plate 12 drives the synchronous movement of the movable clamping plate 21 during the movement. After the movable clamping plate 21 cooperates with the fixed clamping plate 22 to fix and align the solid-phase extraction column 16, the high-pressure gas will enter the upper part of the solid-phase extraction column 16 through the pressurizing pipe 15 (see Figure 6 , In the initial state, the piston plate 12 is located on the left side of the pressurizing pipe 15, and when the piston plate 12 is displaced to the right side of the pressurizing pipe 15, the high-pressure gas can flow into the pressurizing pipe 15). The purpose of alignment is to make the liquid level of the sample solvent in the solid-phase extraction column 16 in a horizontal state, so that after the high-pressure gas enters the inside of the solid-phase extraction column 16, it can generate uniform downward thrust on the sample solvent, so that the sample solvent flows uniformly through the filler 37, and better enriches and separates the analyte in the filler 37.

[0039] During use, when the high-pressure gas enters the inside of the piston cylinder 11, the piston plate 12 inside it is displaced in the horizontal direction under the action of the high-pressure gas, and during the displacement process, the square plate 19 is driven to move synchronously by the push rod 18, and the movable clamping plate 21 is driven to move by the square plate 19 and cooperates with the fixed clamping plate 22 to align and fix the solid-phase extraction column 16, and make the liquid level of the sample solvent in the solid-phase extraction column 16 in a horizontal state. After the solid-phase extraction column 16 is aligned and fixed, the piston plate 12 is just displaced to the right side of the pressurizing pipe 15 (see Figure 6 ), At this time, the high-pressure gas flows into the solid-phase extraction column 16 just above through the pressurizing pipe 15, and accelerates the filtration of the sample solvent.

[0040] The rest of the structure is the same as that of Example 1.

[0041] Example 3, see Figures 3-9For the third embodiment of the present application, which is different from the second embodiment, the driving assembly comprises a mounting groove formed on the inner wall of the fixed clamping plate 22, a rotating shaft 23 rotatably mounted in the mounting groove, a rotating wheel 24 fixedly mounted on the rotating shaft 23, a transmission gear 25 fixedly mounted on both ends of the rotating shaft 23, a driving gear 26 rotatably mounted on the side walls of the mounting groove, a rotating rod 27 fixedly mounted between the two driving gears 26, both ends of the rotating rod 27 rotatably penetrating through the two sides of the fixed clamping plate 22, both transmission gears 25 being engaged with the corresponding driving gears 26, and a triggering element being mounted between the rotating rod 27 and the mounting box 9. The triggering element comprises a support block 28 fixedly mounted on the two sides of the fixed clamping plate 22, the two sides of the rotating rod 27 being arranged on the support block 28, a control gear 29 fixedly mounted on both ends of the rotating rod 27, two slide rails 30 fixedly mounted on the side walls of the mounting box 9, two sliding plates 31 slidingly mounted on the two slide rails 30, a plurality of tooth blocks 32 fixedly mounted on the side walls of the sliding plates 31, two guide rails 33 fixedly mounted on the side walls of the adjacent mounting boxes 9, a sliding block 34 slidingly mounted on the guide rail 33, a connecting rod 35 fixedly mounted between the sliding block 34 and the lower end of the corresponding sliding plate 31, a locking rod 36 fixedly mounted on the sliding block 34, and the sliding plates 31 being engaged with the corresponding control gears 29 through the plurality of tooth blocks 32. The surface of the rotating wheel 24 is fixedly sleeved with a rubber ring for increasing friction, and the side edge of the rotating wheel 24 is in the same plane as the surface of the fixed clamping plate 22.

[0042] Specifically, the locking rod 36 is used for limiting and locking the plate 19, and the limiting and locking of the plate 19 by the locking rod 36 makes the push rod 18 and the piston plate 12 unable to move, and thus the high-pressure gas cannot enter the piston cylinder 11. The driving assembly is used in the following manner: only when the piston cylinder 11 at the position where the fixed clamping plate 22 on which the solid-phase extraction column 16 is mounted is internally filled with the high-pressure gas, and the piston cylinder 11 at the position where the solid-phase extraction column 16 is not mounted cannot be internally filled with the high-pressure gas due to the limitation of the locking rod 36. Therefore, no matter how many solid-phase extraction columns 16 an operator needs to simultaneously operate, the operator only needs to start the pressurizing pump, and the high-pressure gas generated by the pressurizing pump will only enter the piston cylinder 11 at the position where the solid-phase extraction column 16 is mounted, which effectively improves the flexibility of the device and reduces the experimental cost. The working principle of the driving assembly is as follows: when the operator installs the solid-phase extraction column 16, the solid-phase extraction column 16 moves downward in the vertical direction, drives the rotating wheel 24 to rotate, and then drives the control gear 29 to rotate through the transmission gear 25, the driving gear 26, and the rotating rod 27. The control gear 29 drives the sliding plate 31 to move downward in the rotating process, and then drives the locking rod 36 to move downward through the connecting rod 35 and the sliding block 34, and releases the locking of the plate 19 by the locking rod 36, so that the high-pressure gas only enters the piston cylinder 11 at the position where the solid-phase extraction column 16 is placed.

[0043] During use, the operator inserts the solid phase extraction column 16 between the fixed clamping plate 22 and the movable clamping plate 21 and places it in the extraction hole. During placement, the solid phase extraction column 16 moves downward and drives the rotating wheel 24 to rotate under the action of friction. The rotating wheel 24 drives the transmission gears 25 at both ends to rotate through the rotating shaft 23. The transmission gears 25 drive the sliding plate 31 to move downward through the drive gears 26, the rotating rod 27 and the control gears 29. The sliding plate 31 moves downward and drives the corresponding sliding block 34 to move synchronously through the connecting rod 35. The sliding block 34 moves downward and releases the locking of the opposite plate 19. When high-pressure gas is introduced, the high-pressure gas can drive the corresponding piston plate 12 to move and enter the solid phase extraction column 16 through the pressurizing pipe 15.

[0044] The rest of the structure is the same as that of Example 2.

[0045] In combination with Examples 1-3, the working principle of the present application is as follows: when performing activation, sample loading and elution operations, the operator inserts the solid phase extraction column 16 between the fixed clamping plate 22 and the movable clamping plate 21 and places it in the extraction hole. During placement, the solid phase extraction column 16 moves downward and drives the rotating wheel 24 to rotate under the action of friction. The rotating wheel 24 drives the transmission gears 25 at both ends to rotate through the rotating shaft 23. The transmission gears 25 drive the sliding plate 31 to move downward through the drive gears 26, the rotating rod 27 and the control gears 29. The sliding plate 31 moves downward and drives the corresponding sliding block 34 to move synchronously through the connecting rod 35. The sliding block 34 moves downward and releases the locking of the opposite plate 19.

[0046] Place the waste tank 2 in the placement cavity of the cylinder body 1. Connect the gas inlet valve 7 on the gas inlet box 6 with the pressurizing pump. Inject the sample solvent into the solid phase extraction column 16 through the liquid feeding pipe 17 and close the liquid feeding pipe 17. Turn on the pressurizing pump. The pressurizing pump injects the compressed gas into the piston cylinder 11 through the gas transmission pipe 8, the flow box 10 and the gas conveying pipe 14. As the high-pressure gas in the piston cylinder 11 continuously increases, the piston plate 12 in the piston cylinder 11 moves horizontally.

[0047] During displacement, the square plate 19 drives the movable clamping plate 21 to move and cooperates with the fixed clamping plate 22 to properly position and fix the solid phase extraction column 16, and makes the sample solvent liquid surface in the solid phase extraction column 16 be in a horizontal state. After the solid phase extraction column 16 is properly positioned and fixed, the piston plate 12 is just displaced to the right side of the pressurizing pipe 15 (see Figure 6 ).

[0048] When the piston plate 12 moves to the right of the pressurizing pipe 15, high pressure gas is injected into the upper end of the solid phase extraction column 16 through the pressurizing pipe 15, and the high pressure gas generates a downward thrust on the sample solvent in the solid phase extraction column 16, thereby accelerating the filtration of the sample solvent by the filler 37 and enriching and separating the analyte in the filler 37.

[0049] When the operator needs to perform elution, the waste liquid tank 2 is removed, and the sample rack 4 with the sample tube 5 is completely placed in the placement cavity, at this time, the pressurizing pump is controlled to be pressurized, high pressure gas enters the inside of the solid phase extraction column 16, the solvent flows through the filler 37, and the filler 37 and the separated and enriched analyte are taken into the sample tube 5, thereby completing the collection and processing of the enriched and separated sample.

[0050] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present application and are not limiting. Although the present application has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solutions of the present application can be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present application, and they should be covered in the scope of the claims of the present application.

Claims

1. A solid-phase extraction device for ion chromatography, comprising a cylinder and a waste liquid tank, a panel disposed on the cylinder, a sample rack disposed within the cylinder, a plurality of placement holes formed at the upper end of the sample rack, and sample tubes disposed within the placement holes, characterized in that: It also includes a solid phase extraction unit disposed on the upper end of the panel, the solid phase extraction unit including a pressurizing component and an aligning component disposed on the upper end of the panel; The pressurizing component includes an air intake box provided at the upper end of the panel, an air intake valve provided on the air intake box, two air transmission pipes provided on both sides of the air intake box, a plurality of mounting boxes provided at the upper end of the panel, a circulation box provided inside the mounting box, a plurality of piston cylinders provided inside the mounting box, a plurality of piston plates slidably provided inside the plurality of piston cylinders, a return spring provided between the piston plate and the inner wall of the piston cylinder, an air transmission pipe provided between the piston cylinder and the circulation box, a pressurizing pipe provided at the upper ends of the plurality of piston cylinders, a plurality of extraction holes provided on the panel, and a solid phase extraction column provided in the extraction holes; The waste liquid tank and the sample rack are both placed inside the cylinder body and located below the multiple extraction holes. The two air transfer tubes are fixedly connected to the two ends of the circulation box respectively. The multiple air delivery tubes are fixedly connected to the corresponding piston cylinders and the circulation box. The end of the pressurizing tube away from the piston cylinder is fixedly connected to the upper end of the solid phase extraction column. The multiple placement holes on the sample rack and the corresponding multiple extraction holes are on the same horizontal plane. A liquid adding tube for adding solvent is fixedly connected to the side wall of the solid phase extraction column.

2. The solid phase extraction device based on ion chromatography according to claim 1, characterized in that: The straightening component includes a push rod arranged on the side wall of the piston plate, a square plate arranged at one end of the push rod, multiple buffer springs arranged on the side wall of the square plate, a movable splint arranged at one end of the multiple buffer springs, and a fixed splint arranged on the adjacent installation box, wherein a driving component is arranged in the fixed splint.

3. The solid phase extraction device based on ion chromatography according to claim 2, characterized in that: The driving assembly includes a mounting groove on the inner wall of the fixed splint, a rotating shaft arranged in the mounting groove, a rotating wheel arranged on the rotating shaft, transmission gears arranged at both ends of the rotating shaft, driving gears arranged on the side walls on both sides of the mounting groove, and a rotating rod arranged between the two driving gears. Both ends of the rotating rod rotate and pass through both sides of the fixed splint, and the two transmission gears are engaged with the corresponding driving gears. A trigger element is installed between the rotating rod and the mounting box.

4. The solid phase extraction device based on ion chromatography according to claim 3, characterized in that: The trigger element includes support blocks arranged on both sides of the fixed splint, and both sides of the rotating rod are arranged on the support blocks, control gears arranged at both ends of the rotating rod, two slide rails arranged on the side walls of the installation box, two slides slidably arranged on the two slide rails, multiple tooth blocks arranged on the side walls of the slide, two guide rails arranged on the side walls of the adjacent installation boxes, a slider slidably arranged on the guide rails, a connecting rod arranged between the slider and the lower end of the corresponding slider, and a locking rod arranged on the slider, and the slider is meshed with the corresponding control gear through multiple tooth blocks.

5. The solid phase extraction device based on ion chromatography according to claim 3, characterized in that: The surface fixing sleeve of the rotating wheel is provided with a rubber ring for increasing friction, and the side edge of the rotating wheel and the surface of the fixing splint are in the same plane.

6. The solid phase extraction device based on ion chromatography according to claim 5, characterized in that: The fixed splint and the movable splint are both semicircular rings.

7. The solid phase extraction device based on ion chromatography according to claim 1, characterized in that: A placement cavity is provided inside the cylinder body, and the shape and size of the end faces of the sample rack and the waste liquid tank are equal to the shape and size of the end face of the placement cavity.

8. The solid phase extraction device based on ion chromatography according to claim 1, characterized in that: The inner bottom end of the solid phase extraction column is filled with fillers.

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