Application of THBS1 as a marker of radiation-induced liver injury and its detection kit
CN120801726BActive Publication Date: 2025-11-14GENERAL HOSPITAL OF THE NORTHERN WAR ZONE OF THE CHINESE PEOPLES LIBERATION ARMY
Patent Information
- Application Number
- CN202511301178.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-09-12
- Publication Date
- 2025-11-14
- Estimated Expiration
- 2045-09-12
AI Technical Summary
Technical Problem
[0009]综上所述，现有技术中，RILI的发病机制（尤其是纤维化机制）尚未完全明确，缺乏特异性高、敏感性强的生物标志物用于早期诊断与病情监测
Benefits of technology
[0064]1、特异性高，可区分放射性肝损伤与正常状态及其他肝损伤
✦ Generated by Eureka AI based on patent content.
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Figure CN120801726B_ABST
Abstract
This invention discloses the application of THBS1 as a biomarker for radiation-induced liver injury and its detection kit. The plasma concentration of this protein is <13 ng / mL under normal conditions and >20 ng / mL under radiation-induced liver injury conditions, exhibiting high specificity and sensitivity. The kit, based on the sandwich ELISA principle, can rapidly detect THBS1 concentration in plasma, enabling early diagnosis, severity assessment, and prognostic monitoring of radiation-induced liver injury, providing a reliable diagnostic tool for clinical practice.
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Citation Information
Patent Citations
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