Sunscreen composition for protecting skin microbiome

Abstract

The present invention relates to a sunscreen or daily care composition for use in a method of protecting the skin microbiome from UV light irradiation comprising a first UV filter wherein the first UV filter is 2-[4-(diethylamino)-2-hydroxybenzoyl] hexyl benzoate (INCI diethylamino hydroxybenzoyl hexyl benzoate); and a second UV filter, where the second UV filter is selected from the group consisting of: (tris (2-ethylhexyl)-4, 4 '-diphenyl-1, 3, 4-triazole-1-yl)-1, 3, 4-triazole-1-yl The present invention relates to compounds of formula (I), in particular, 2, 4 ', 4' '-(1, 3, 5-triazine-2, 4, 6-triyltriamino) tribenzoate) (INCI ethylhexyltriazinone), 2, 4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1, 3, 5-triazine (INCI bis-ethylhexyloxyphenol methoxyphenyl triazine), and mixtures thereof.

Description

TECHNICAL FIELD

[0001] The present invention relates to a sunscreen or daily care composition comprising certain UV filters for use in a method of protecting the skin microbiome from UV irradiation, and the same sunscreen or daily care composition for use in a method of increasing the viability of the skin microbiome under UV irradiation, and a combination of UV filters for use in a method of protecting the skin microbiome from UV radiation. BACKGROUND

[0002] UV radiation causes harmful effects on human skin. In addition to the acute effects of sunburn on the skin, UV radiation is known to increase the risk of skin cancer. Furthermore, long-term exposure to UV-A and UV-B light can cause phototoxic and photoallergic reactions on the skin and can accelerate skin aging.

[0003] In order to protect human skin from UV radiation, various sunscreen UV filters (also known as UV absorbers) exist, including UV-A filters (also known as UVA filters), UV-B filters (also known as UVB filters) and broadband filters. These filters are added to sunscreen or daily care compositions. UV filters are organic or inorganic, microparticulate or non-microparticulate compounds which have a high absorption efficacy in the UV light range. Generally, UV light associated with skin health can be divided into UV-A radiation (320-400 nm) and UV-B radiation (290-320 nm). Depending on the position of the absorption maximum, UV filters are divided into UV-A and UV-B filters. In case a UV filter absorbs both UV-A and UV-B light, it is referred to as a broadband absorber.

[0004] Since 2006, the European Commission has recommended that all sunscreens should have a UV-A protection factor which is at least one third of the indicated sun protection factor (SPF), where the sun protection factor mainly refers to UV-B protection. This also applies to daily care compositions with UV protection in order to effectively protect consumers from long-term UV damage provided by UV-A radiation.

[0005] Human skin comprises millions of bacteria, fungi and viruses which constitute the skin microbiome. These organisms have an important role in, for example, fending off invading pathogens. When the barrier provided by these organisms is broken, humans are susceptible to attack by invading pathogens. It is known that, for example, compounds contained in cosmetic products tend to break the barrier.

[0006] Furthermore, the skin microbiome is also directly damaged by UV irradiation. UV irradiation affects the health of the skin microbiome and can greatly reduce the number of microorganisms which provide valuable protection for human skin against pathogens.

[0007] Therefore, there is a need to find sunscreen compositions that can effectively protect the skin microbiome from damage by UV light irradiation. At the same time, these sunscreen compositions should be compatible with the skin microbiome.

[0008] It is an object of the present invention to provide a sunscreen or daily care composition that protects the skin microbiome from damage caused by UV light irradiation. Furthermore, it is an object of the present invention to provide a microbiome-friendly sunscreen or daily care composition. Furthermore, it is an object to provide a sunscreen or daily care composition comprising a UV filter with good compatibility with the skin microbiome. Furthermore, it is an object of the present invention to provide a sunscreen or daily care composition that increases the viability of the skin microbiome under UV light irradiation. SUMMARY

[0009] Surprisingly, it has been found that at least one of these objects can be achieved by a sunscreen or daily care composition comprising

[0010] - a first UV filter, wherein the first UV filter is 2-[4-(diethylamino)-2- hydroxybenzoyl]benzoic acid hexyl ester (INCI Diethylamino Hydroxybenzoyl Hexyl Benzoate); and

[0011] - a second UV filter, wherein the second UV filter is selected from the group consisting of (tris(2-ethylhexyl)-4,4',4"-(1,3,5-triazine-2,4,6-triazinyltriimino)tribenzoate) (INCI Ethylhexyl Triazone), 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine), and mixtures thereof.

[0012] Surprisingly, it has been found that sunscreen or daily care compositions comprising this specific combination of UV filters are very suitable for protecting the skin microbiome from UV irradiation. Sunscreen or daily care compositions with different UV filters do not show the same level of protection against UV irradiation damage to the skin microbiome.

[0013] According to a first aspect, the present invention relates to a sunscreen or daily care composition for use in a method of protecting the skin microbiome from damage by UV light irradiation, comprising

[0014] - a first UV filter, wherein the first UV filter is 2-[4-(diethylamino)-2- hydroxybenzoyl]benzoic acid hexyl ester (INCI Diethylamino Hydroxybenzoyl Hexyl Benzoate); and

[0015] - a second UV filter, wherein the second UV filter is selected from the group consisting of (tris(2-ethylhexyl)-4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyl Triazone), 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4- methoxyphenyl)-1,3,5-triazine (INCI Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine), and mixtures thereof.

[0016] According to a second aspect, the present application relates to a sunscreen or daily care composition for use in a method of increasing the viability of the skin microbiome under UV light irradiation, comprising

[0017] - a first UV filter, wherein the first UV filter is 2-[4-(diethylamino)-2- hydroxybenzoyl]benzoic acid hexyl ester (INCI Diethylamino Hydroxybenzoyl Benzoyl Hexyl Esters); and

[0018] - a second UV filter, wherein the second UV filter is selected from the group consisting of (tris(2-ethylhexyl)-4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyl Triazone), 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4- methoxyphenyl)-1,3,5-triazine (INCI Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine), and mixtures thereof.

[0019] According to a third aspect, the present application relates to a UV filter combination of 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester (INCI Diethylamino Hydroxybenzoyl Benzoyl Hexyl Esters) with 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4- methoxyphenyl)-1,3,5-triazine (INCI Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine) and / or (tris(2-ethylhexyl)-4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyl Triazone) for use in a method of protecting the skin microbiome from UV radiation.

[0020] In the following, preferred embodiments of the above aspects are described in further detail. It is to be understood that each preferred embodiment is relevant per se as well as in combination with other preferred embodiments.

[0021] The statements made within the present application in relation to the features of the first aspect of the application also apply to the other aspects of the application and vice versa. Thus, the specifications of the features of the sunscreen or daily care compositions used, such as components, or the properties of these compositions discussed in relation to one aspect of the application equally apply to the other aspects of the application. BRIEF DESCRIPTION OF DRAWINGS

[0022] Figure 1 Results of survival tests of S. epidermidis under different conditions and for different cosmetic formulations are depicted.

[0023] Figure 2 Results of survival tests of S. hominis under different conditions and for different cosmetic formulations are depicted.

[0024] Figure 3 Results of survival tests of C. acnes under different conditions and for different cosmetic formulations are depicted.

[0025] DEFINITIONS

[0026] As used in the present description and the appended claims, the singular form "a", "an" and "the" include plural references unless the context clearly dictates otherwise. In the context of the present invention, the terms "about" and "approximately" denote an interval of accuracy which will be understood by those skilled in the art to ensure the technical effect of the feature under discussion. The terms typically indicate a deviation of ±20%, preferably of ±15%, more preferably of ±10%, and even more preferably of ±5% from the indicated numerical value. It is understood that the term "comprising" is not limiting. For the purposes of the present invention, the term "consisting of" is considered to be a preferred embodiment of the term "consisting". If a group is defined in the following text as comprising at least a certain number of embodiments, this means that a group comprising preferably only these embodiments is also encompassed. Furthermore, the terms "first", "second", "third" or "(a)", "(b)", "(c)", "(d)" etc. in the description and in the claims are used for distinguishing between like elements and not necessarily for describing sequential or chronological order. It is to be understood that the terms so used are interchangeable under appropriate circumstances and that the embodiments of the invention described herein are capable of operating in other sequences than described or illustrated herein. In cases where the terms "first", "second", "third" or "(a)", "(b)", "(c)", "(d)", "i", "ii", etc. refer to steps of a method or use or test, there is no time or time interval relative in between these steps, i.e. the steps can be carried out simultaneously or there can be time intervals of seconds, minutes, hours, days, weeks, months or even years between such steps, unless otherwise indicated in the application as described herein above or below. It is to be understood that the invention is not limited to the particular methodology, protocols, reagents etc. described herein as these can vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the scope of the present invention which will be limited solely by the appended claims. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art.

[0027] As used herein, the term "does not contain / comprise" or "free of" means in the context of the present invention that the composition does not contain a group of specific compounds or compounds (which can be combined under a certain collective term) in an amount of more than 0.8% by weight based on the total weight of the composition. Furthermore, it is preferred that the composition according to the present invention does not contain the group of compounds in an amount of more than 0.5% by weight, preferably the composition does not contain the group of compounds at all.

[0028] When referring to the weight percentage of the composition and of the ingredients contained therein, it is understood that the total amount of ingredients does not exceed 100% (±1% due to rounding) according to the present invention.

[0029] The term "cosmetic composition" means any topical product intended to be applied to the human body to clean, beautify, promote attractiveness, alter the appearance, or to protect the skin without affecting the body's structure or function. Possible cosmetic compositions within the meaning of the present application include leave-on and rinse-off products, such as facial and body care, including daily care compositions with or without UV protection as well as sunscreen and sun protection compositions, hair care products such as shampoos, conditioners, shower gels, make-up compositions and similar compositions.

[0030] The term "sunscreen composition" or "sunscreen" means any topical product that absorbs and can further reflect and scatter certain parts of UV radiation. Thus, the term "sunscreen composition" is to be understood as including not only sunscreen compositions, but also any cosmetic composition that provides UV protection. The term "topical product" means a product that is applied to the skin and can mean, for example, a spray, a lotion, a cream, an oil, a foam, a powder or a gel. According to the present application, the sunscreen composition can comprise one or more active agents, such as organic and inorganic UV filters, as well as other ingredients or additives, such as emulsifiers, emollients, viscosity regulators, stabilizers, preservatives or fragrances.

[0031] The term "daily care composition" means any topical product with or without UV protection that is intended to be used daily. In the case of including UV protection, it absorbs and can further reflect and scatter certain parts of UV radiation and serves as a daily care product for the human body, for example the face or the body. The daily care composition can comprise one or more active agents, such as organic and / or inorganic UV filters, as well as other ingredients or additives, such as emulsifiers, emollients, viscosity regulators, stabilizers, preservatives or fragrances. According to the present application, suitable daily care compositions are, for example, leave-on facial and body care products.

[0032] Suitable leave-on products for the face and body are, for example, sunscreen compositions, make-up preparations and skin care preparations.

[0033] Suitable make-up preparations are, for example, lipsticks, nail varnishes, eye shadows, mascaras, dry and wet make-up foundations, blushes, powders.

[0034] Suitable skin care preparations are, for example, moisturizing preparations, improving preparations and lifting preparations. The listed leave-on compositions can be in the form of a cream, an ointment, a paste, a foam, a gel, a lotion, a powder, a spray, a stick or an aerosol. Daily care compositions with UV protection protect human skin from the damaging effects of UV light.

[0035] As used herein, the term "UV filter" or "ultraviolet filter" refers to an organic or inorganic compound which can absorb and can further reflect and scatter UV radiation resulting from sunlight. UV filters can be classified as UV-A, UV-B or broadband filters based on their UV absorbance profile. Preferably, the term "UV filter" comprises or consists of any UV filter defined in Annex VI of the Regulation (EC) No. 1223 / 2009 of the European Parliament and of the Council (version of 11 November 2022).

[0036] Water-soluble UV filters have a solubility in water of at least 2% by weight, preferably at least 3% by weight, more preferably at least 5% by weight.

[0037] Oil-soluble filters have a solubility in a specific emollient of at least 2% by weight, preferably at least 3% by weight, more preferably at least 5% by weight.

[0038] The prefix Cn-Cm indicates in each case the number of possible carbon atoms in the radical.

[0039] The term "C12-C15-alkyl benzoate" refers to esters of benzoic acid with fatty alcohols containing a C12-C15-alkyl chain. A C12-C15-alkyl chain is defined as an alkyl chain having a chain length of C12, C13, C14 or C15.

[0040] As used herein, the term "Cn-Cm carboxylic acid" denotes in each case a straight-chain or branched carboxylic acid having from n to m carbon atoms, such as 6 to 24 carbon atoms.

[0041] As used herein, the term "Cn-Cm alcohol" denotes in each case a straight-chain or branched alcohol having from n to m carbon atoms, such as having from 3 to 24 carbon atoms, or from 6 to 24 carbon atoms, or from 1 to 22 carbon atoms.

[0042] As used herein, the term "C2-C12 dicarboxylic acid" denotes in each case a dicarboxylic acid having from 2 to 12 carbon atoms, such as butanedioic acid (succinic acid), pentanedioic acid (glutaric acid), hexanedioic acid (adipic acid) or decanedioic acid (sebacic acid).

[0043] As used herein, the term "dialkyl ether" denotes in each case a straight-chain or branched dialkyl ether having in total from 12 to 36 carbon atoms and comprising at least one ether moiety.

[0044] As used herein, the term "C6-C22alcohol carbonate" denotes linear or branched alcohol carbonates having in each case from 6 to 22 carbon atoms and comprising at least one functional group consisting of a carbonyl flanked by two alkoxy groups.

[0045] As used herein, the term "alkyl" denotes a straight-chain or branched alkyl group having in each case exemplarily from 1 to 18 carbon atoms. Examples of alkyl groups are methyl, ethyl, n-propyl, i-propyl, n-butyl, 2-butyl, i-butyl, t-butyl, n-pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, n-hexyl, 1,1-dimethyl-propyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl, and 1-ethyl-2-methylpropyl.

[0046] As used herein, the term "alkoxy" denotes a straight-chain or branched alkyl group which is bound in each case via an oxygen atom and which generally has from 1 to 20 carbon atoms. Examples of alkoxy groups are methoxy, ethoxy, n-propoxy, i-propoxy, n-butoxy, 2-butoxy, i-butoxy, t-butoxy and the like.

[0047] As used herein, the term "carboxyalkyl" includes carboxymethyl, carboxyethyl, carboxypropyl, carboxyisopropyl, carboxybutyl, carboxyisobutyl, carboxypentyl, carboxyhexyl, carboxyheptyl, carboxyoctyl, carboxyisooctyl, carboxynonyl, carboxydecyl, carboxyundecyl, carboxydodecyl, carboxytetradecyl, carboxyhexadecyl and carboxyoctadecyl, preferably carboxymethyl.

[0048] As used herein, the term "cycloalkyl" denotes monocyclic alicyclic groups which generally have in each case from 3 to 10 or from 5 to 8 carbon atoms, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl and cyclodecyl, or cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.

[0049] As used herein, the term "substituted" means that a hydrogen atom bound to the specified atom is replaced with a specified substituent, provided that the substitution results in a stable or chemically feasible compound. Unless otherwise indicated, a substituted atom can have one or more substituents and each substituent is independently selected.

[0050] The term "emollient" relates to cosmetic-specific oils used to protect, moisturize and lubricate the skin. The word "emollient" is derived from the Latin verb mollire, meaning to soften. Generally, emollients prevent water from evaporating from the skin by forming a closed coating. Alternatively or additionally, emollients improve the distribution of the product on the skin. Emollients can be classified into different groups according to their polarity index.

[0051] The term "sensitive skin" refers to a skin whose natural barrier function is weakened and has been disrupted by triggering factors. The triggering factors can be, for example, cold weather, very hot water, and key ingredients that can be included in a sunscreen or daily care composition.

[0052] As used herein, the term "Sun Protection Factor (SPF)" indicates the degree to which a sunscreen composition protects the skin from the sun, mainly from UV-B radiation. In particular, this factor indicates how long the protected skin can be exposed to the sun without getting sunburned compared to untreated skin. For example, if a sunscreen composition with an SPF of 15 is uniformly applied to the skin of a person who normally gets sunburned after 10 minutes in the sun, the sunscreen allows the technician to stay in the sun 15 times longer. In other words, SPF 15 means that 1 / 15 of the intense UV radiation will reach the skin, assuming a uniform application of the sunscreen with a thick dose of 2 milligrams per square centimeter (mg / cm2).

[0053] The definition of "broadband" protection, also called broad spectrum or extensive protection, can be based on, for example, the "cut-off wavelength" or the UVA-PF. For broadband coverage, UV-B and UV-A protection must be provided. According to the requirements in the United States, a cut-off wavelength of at least 370 nm is required to achieve broad spectrum protection. In addition, the European Commission recommends that all sunscreen or cosmetic compositions should have a UV-A protection factor that is at least one third of the indicated sun protection factor (SPF), for example if a sunscreen composition has an SPF of 30, the UVA protection factor must be at least 10.

[0054] The term "cut-off wavelength" is defined as the wavelength at which the area under the UV protection curve (protection % vs. wavelength) accounts for 90% of the total area under the curve in the UV region (290-400 nm). For example, a cut-off wavelength of 370 nm indicates that the protection of the sunscreen composition is not limited to the wavelengths of UV-B (i.e. 290-320 nm), but extends to 370 nm, so that a minimum of 90% of the total area under the protection curve in the UV region is reached at 370 nm.

[0055] The term "application" means the spreading of a sunscreen or daily care composition on the skin of a person. DETAILED DESCRIPTION

[0056] The first aspect of the application relates to a sunscreen or daily care composition for use in a method of protecting the skin microbiota from damage by UV light exposure, comprising

[0057] - a first UV filter, wherein the first UV filter is 2-[4-(diethylamino)-2- hydroxybenzoyl]benzoic acid hexyl ester (INCI Diethylamino Hydroxybenzoyl Hexyl Benzoate); and

[0058] - a second UV filter, wherein the second UV filter is selected from the group consisting of (tris(2-ethylhexyl)-4,4',4"-(1,3,5-triazine-2,4,6-triyl triimino)tribenzoate) (INCI Ethylhexyl Triazone), 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine), and mixtures thereof.

[0059] Surprisingly, it was found that a sunscreen or daily care composition comprising a combination of Diethylamino Hydroxybenzoyl Hexyl Benzoate (DHHB) with Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine (BEMT) and / or Ethylhexyl Triazone (EHT) is effective in protecting the skin microbiota from damage by UV light exposure. Interestingly, this particular combination of UV filters in a sunscreen or daily care composition is better suited for protecting the skin microbiota from damage by UV light exposure than alternative combinations of UV filters.

[0060] As mentioned above, the skin microbiome comprises many organisms which are important for protecting e.g. mammals such as humans from pathogenic invaders. It is known that UV irradiation has a negative impact on the skin microbiome. It is further known that several compounds have a negative impact on the skin microbiome. It is to be understood that "protecting the skin microbiome from damage by UV light irradiation" means that a composition of the present application comprising a specific combination of UV filters maintains a greater microbial population upon exposure to UV irradiation compared to the case of an exactly identical composition which does not comprise the specific combination of UV filters. It is to be understood that "increasing the compatibility of a sunscreen or daily composition with the skin microbiome" according to the present application means that a composition of the present application comprising one of the specific UV filters has a greater microbial population than an exactly identical composition which does not comprise the specific UV filter. Suitable representatives of the microorganisms of the skin microbiome are e.g. Cutibacterium acnes, Staphylococcus epidermidis, Staphylococcus hominis, Micrococcus luteus and Corynebacterium jeikeium.

[0061] According to a preferred embodiment, the present application relates to a sunscreen or daily care composition for use in a method of protecting a population of bacteria selected from the group consisting of Cutibacterium acnes, Cutibacterium granulosum, Cutibacterium avidum, Staphylococcus epidermidis, Staphylococcus saprophyticus, Staphylococcus hominis, Staphylococcus xylosus, Staphylococcus warneri, Staphylococcus haemolyticus, Staphylococcus saccharolyticus, Staphylococcus conii, Staphylococcus auricularis, Micrococcus luteus, Corynebacterium minutissimum, Corynebacterium jeikeium, Corynebacterium tuberculostearicum, Corynebacterium fastidiosum, Corynebacterium simulans, Corynebacterium amycolatum, Corynebacterium xerosis, Streptococcus mitis, Streptococcus sanguinis, Streptococcus oralis, Brevibacterium spp., Pseudomonas spp., and mixtures thereof, in the skin microbiome from damages by UV light exposure.

[0062] According to a particularly preferred embodiment, the present application relates to a sunscreen or daily care composition for use in a method of protecting a population of bacteria of Staphylococcus hominis, Staphylococcus epidermidis, Cutibacterium acnes, and mixtures thereof, in the skin microbiome from damages by UV light exposure.

[0063] According to another preferred embodiment, the present application relates to a sunscreen or daily care composition for use in a method for protecting a fungal population selected from the group consisting of Malassezia furfur, Malassezia restricta, Malassezia globosa, Candida spp., and mixtures thereof, in the skin microbiome from UV light exposure damages.

[0064] According to another preferred embodiment, the sunscreen or daily care composition further comprises at least one additional UVB filter or broadband filter, which is preferably selected from the group consisting of 4,4'-[[6-[[4-[[(1,1 -dimethylethyl)amino]carbonyl]phenyl]amino]- 1,3,5-triazine-2,4-diyl]diimino]bis-benzoic acid-bis(2-ethylhexyl) ester (INCI Diethylhexyl Butamido Triazone or DBT), phenyl-3H-benzimidazole-5-sulfonic acid (INCI Phenyl Benzoimidazole Sulfonic Acid or PBSA), dimethicodiethyelhexyl butamido triazone (INCI Dimethicone-Benzylidene Malonate), 2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1- disiloxanyl]propyl]phenol (INCI Drometrizole Trisiloxane), and mixtures thereof. Among these preferred additional UVB and broadband filters, phenyl-3H-benzimidazole-5-sulfonic acid (INCI Phenyl Benzoimidazole Sulfonic Acid or PBSA) is particularly preferred.

[0065] In another preferred embodiment of the present application, the sunscreen or daily care composition further comprises at least one organic micronized UV filter selected from the group consisting of 2,2'-methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol] (INCI Methylene Bis-benzotriazolyl Tetramethylbutylphenol), 2,4,6-tris(biphenyl-4-yl)-1,3,5-triazine (INCI Tris-biphenyl Triazine), 5,6,5',6'-tetraphenyl-3-3'-(1,4-phenylene)bis(1,2,4-triazine) (INCI Phenylene Bis-diphenyltriazine), 1,1 '-(1,4-piperazinediyl)bis[1 -[2-[4-(diethylamino)-2-hydroxybenzoyl]phenyl]- methanone (INCI Bis-(diethylaminohydroxybenzoyl)benzoyl Piperazine); preferably 2,2'-methylenebis[4-(1,1,3,3-tetramethylbutyl)-6-(2H-benzotriazol-2-yl)phenol] (INCI Methylene Bis-benzotriazolyl Tetramethylbutylphenol) and / or 2,4,6-tris(biphenyl-4-yl)-1,3,5-triazine (INCI Tris-biphenyl Triazine). In case the sunscreen or daily care composition comprises such an organic micronized UV filter, it is preferred that the at least one organic micronized UV filter is not dispersed in (3R,4S,5S,6R)-2-(decyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (INCI Decyl Glucoside).

[0066] In a preferred embodiment, the organic micronized UV filter is dispersed in a polyglyceryl monoalkyl ester. Preferably, the polyglyceryl monoalkyl ester is selected from the group consisting of decanoic acid decaglyceryl ester, monolauric acid decaglyceryl ester, myristic acid decaglyceryl ester, oleic acid decaglyceryl ester, stearic acid decaglyceryl ester, isostearic acid decaglyceryl ester, decanoic acid hexaglyceryl ester, lauric acid hexaglyceryl ester, myristic acid hexaglyceryl ester, oleic acid hexaglyceryl ester, stearic acid hexaglyceryl ester, isostearic acid hexaglyceryl ester, decanoic acid pentaglyceryl ester, lauric acid pentaglyceryl ester, myristic acid pentaglyceryl ester, oleic acid pentaglyceryl ester, stearic acid pentaglyceryl ester, isostearic acid pentaglyceryl ester, and mixtures thereof, more preferably wherein the at least one polyglyceryl monoalkyl ester is monolauric acid decaglyceryl ester (INCI Polyglyceryl-10 Laurate).

[0067] According to another preferred embodiment, the sunscreen or daily care composition further comprises at least one additional UVA filter, which is preferably selected from the group consisting of [(3Z)-3-[[4-[(Z)-[7,7-dimethyl-2-oxo-1-(sulfomethyl)-3- bicyclo[2.2.1]hept-2-enyl]methyl]phenyl]methylene]-7,7-dimethyl-2-oxo-1- bicyclo[2.2.1]heptanyl]methanesulfonic acid (INCI Terephthalylidene Dihydroxydibenzo- sylulphonate), Disodium Phenyl Dibenzimidazole Tetrasulfonate, 1-(4-(1,1-Dimethyl- ethyl)phenyl)-3-(4-methoxyphenyl)propane-1,3-dione (INCI Butyl Methoxydibenzoyl- methane), and mixtures thereof, in particular 1-(4-(1,1-Dimethyl-ethyl)phenyl)-3-(4- methoxyphenyl)propane-1,3-dione (INCI Butyl Methoxydibenzoylmethane).

[0068] A particularly preferred embodiment is that the sunscreen or daily care composition is free of zinc oxide (ZnO). It has been found that zinc oxide is harmful to the skin microbiome. In another preferred embodiment, the sunscreen or daily care composition is free of zinc derived compounds. According to the present application, zinc derived compounds means every compound comprising a zinc atom.

[0069] In a preferred embodiment, the sunscreen or daily care composition is free of zinc salts. In a particularly preferred embodiment, the sunscreen or daily care composition is free of zinc salts of pyrrolidone carboxylic acid.

[0070] In a preferred embodiment, the sunscreen or daily care composition is free of parabens.

[0071] In a preferred embodiment, the sunscreen or daily care composition is free of PVP (polyvinyl pyrrolidone) polymers and VP (vinyl pyrrolidone) derivatives such as vinyl pyrrolidone / hexadecene copolymer, VP / eicosene copolymer, tricontyl PVP.

[0072] In a preferred embodiment, the sunscreen or daily care composition is free of acrylic acid based polymers such as for example without limitation compounds having INCI Carbomer, Acrylates / C10-30 alkyl acrylate crosspolymer.

[0073] According to a preferred embodiment of the present application, the sunscreen or daily care composition comprises 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester (INCI Diethylamino Hydroxybenzoyl Hexyl Benzoate) in an amount of 0.1 to 10.0 wt.-%, preferably 0.5 to 8.0 wt.-%, and in particular 1.0 to 5.0 wt.-%, based on the total weight of the sunscreen or daily care composition.

[0074] According to another preferred embodiment, the sunscreen or daily care composition comprises 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis- Ethylhexyloxyphenol Methoxyphenyl Triazine) in an amount of 0.1 to 7.0 wt.-%, preferably 0.5 to 4.0 wt.-%, most preferably 1.0 to 3.0 wt.-%, based on the total weight of the sunscreen or daily care composition.

[0075] According to another preferred embodiment, the sunscreen or daily care composition comprises (Tris(2-ethylhexyl)-4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyl Triazone) in an amount of 0.1 to 5.0 wt.-%, preferably 0.5 to 4.0 wt.-%, most preferably 0.8 to 3.0 wt.-%, based on the total weight of the sunscreen or daily care composition.

[0076] In preferred embodiments, the sunscreen or daily care composition further comprises a dermatologically acceptable emulsifier, a thickening agent, and / or an emollient.

[0077] Preferred emulsifiers include

[0078] - glucose derivatives, such as cetyl glucoside, arachidyl glucoside, lauryl glucoside, polyglyceryl-3 methyl glucose distearate, methyl glucose sesquistearate;

[0079] - sucrose derivatives, such as sucrose polystearate, sucrose palmitate;

[0080] - sorbitol derivatives;

[0081] - glycerol esters of fatty acids, such as glyceryl stearate, glyceryl oleate;

[0082] - glutamic acid derivatives, such as sodium stearoyl glutamate;

[0083] - sulfosuccinic acid derivatives, such as disodium cetearyl sulfosuccinate;

[0084] - phosphoric acid derivatives, such as potassium cetyl phosphate;

[0085] - polyglyceryl-based fatty acid esters, such as polyglyceryl-3 diisostearate, polyglyceryl-2 dipolyhydroxystearate;

[0086] Preferred emollients include

[0087] - esters of linear or branched fatty acids with linear or branched fatty alcohols, such as propylheptyl octanoate, coco caprylate, isopropyl myristate, ethylhexyl palmitate;

[0088] - esters of aromatic carboxylic acids with linear or branched fatty alcohols, such as benzoic acid Ci2-Ci5-alkyl ester, benzoic acid ethylhexyl ester, benzoic acid phenylethyl ester;

[0089] - dicarboxylic acid esters with linear or branched alcohols, such as dibutyl adipate, dioctyl carbonate, diisopropyl sebacate;

[0090] - esters of hydroxycarboxylic acids with linear or branched fatty alcohols;

[0091] - esters of linear or branched fatty acids with polyols, such as butylenes glycol dioctanoate / didecanoate;

[0092] - glycerol esters based on C6-Ci8fatty acids, such as caprylic / capric triglyceride, coco glyceride;

[0093] - guerbet alcohols, such as octyldodecanol;

[0094] - hydrocarbons, such as hydrogenated polyisobutene, mineral oil, squalene, isohexadecane;

[0095] - ethers, such as dicaprylyl ether;

[0096] - silicone derivatives (organomodified polysiloxanes), such as dimethicopolysiloxane.

[0097] Preferred thickening agents include

[0098] - fatty alcohols, such as cetyl alcohol, cetearyl alcohol, ambrettol, stearyl alcohol;

[0099] - fatty acids, such as stearic acid;

[0100] - fatty acid esters, such as myristyl stearate;

[0101] - C18-38alkyl hydroxystearoyl

[0102] - waxes, such as beeswax, carnauba wax, microcrystalline wax, ceresine, paraffin wax, rice starch wax;

[0103] - polysaccharides or derivatives, such as xanthan gum, guar gum, agar gum, alginate, gellan gum, carrageenan, tara gum;

[0104] - silicate derivatives, such as magnesium silicate;

[0105] - cellulose derivatives, such as hydroxypropyl cellulose.

[0106] In one embodiment, the sunscreen or daily care composition further comprises a sensory enhancer, an adjuvant, a preservative, and / or a fragrance.

[0107] Preferred sensory enhancers include

[0108] - Silica;

[0109] - Mica;

[0110] - Starch derivatives such as aluminum starch octenylsuccinate, tapioca starch, rice starch, maize (corn) starch;

[0111] - Dimethicone derivatives;

[0112] - Boron nitride;

[0113] - Perlite.

[0114] The preferred moisturizers include

[0115] - 1,2 pentanediol;

[0116] - 1,2 hexanediol;

[0117] - 1,2 octanediol;

[0118] - 1,2 decanediol;

[0119] 2-methyl-1,3-propanediol.

[0120] The preferred adjuvants include

[0121] - Tocopherol derivatives;

[0122] - Retinol derivatives;

[0123] - Ascorbic acid derivatives;

[0124] - Farnesol;

[0125] - Allantoin;

[0126] - Panthenol;

[0127] - Chelating agents (EDTA, EDDS, EGTA, phytic acid, piroctone olamine);

[0128] - Ethylhexylglycerin;

[0129] - Hydroxyacetophenone;

[0130] - Caprylhydroxymic acid;

[0131] - Propellants such as propane, butane, isobutene, dimethyl ether;

[0132] - Styrene / PVP or styrene acrylamide copolymer;

[0133] - Insect repellents such as butyl acetyl aminopropionate.

[0134] Preferred preservatives include

[0135] - benzyl alcohol;

[0136] - gingerone.

[0137] Preferred fragrances are selected from the group consisting of limonene, citral, linalool, alpha-isomethyl ionone, geranial, citronellol, 2- isobutyl-4-hydroxy-4-methyltetrahydropyran, 2-tert.-amylcyclohexyl acetate, 3-methyl-5-phenyl-1-pentanol, 7-acetyl-1,1,3,4,4,6- hexamethyltetrahydronaphthalene, adipine acid diester, alpha-amylcinnamaldehyde, alpha-methyl ionone, amyl C-butyl phenyl methyl propional, butyl phenyl methyl propioal, mace oil, cedrol, cinnamaldehyde, cinnamyl alcohol, citronellyl methyl tiglate, lemon oil, coumarin, diethyl succinate, ethyl linalool, eugenol, evernia furfuracea extract, evernia prunastri extract, farensol, guaiac wood oil, hexyl cinnamaldehyde, hexyl salicylate, hydroxycitronellal, lavender oil, lemon oil, linayl acetate, mandarin oil, menthyl PCA, methyl heptenone, mace oil, rosemary oil, sweet orange oil, terpineol, tonka bean oil, triethyl citrate, vanillin, and combinations thereof.

[0138] In connection with the above preferred embodiments, it is to be understood that if the sunscreen or daily care composition comprises two or more additives (e.g. emulsifiers, emollients, thickening agents, organoleptic enhancers, adjuvants, preservatives, fragrances), then also combinations of the additives as defined above are part of the present application.

[0139] In connection with the above preferred and particularly preferred embodiments, it is to be understood that the sunscreen or daily care composition can further comprise water.

[0140] In case water is present in the sunscreen or daily care composition, it is to be understood that it is preferably present in an amount of more than 5% by weight based on the total weight of the composition. Furthermore, it is to be understood that in case water is present in the sunscreen or daily care composition, the sunscreen or daily care composition can be an oil-in-water emulsion (O / W emulsion), a water-in-oil emulsion (W / O emulsion), a gel cream or an oil-in-gel.

[0141] In one embodiment of the present application, the sunscreen or daily care composition can be provided in different forms, such as a gel, a cream, an oil, an emulsion or in the form of a sprayable product.

[0142] The above outlined sunscreen and daily care composition is particularly suitable for sensitive skin.

[0143] The sunscreen or daily care composition can comprise typical sunscreen or daily care composition ingredients (such as emulsifiers, thickeners, emollients, organoleptic enhancers, adjuvants, preservatives, and / or fragrances). Preferably, the sunscreen or daily care composition comprises glycerin. Preferably, the sunscreen or daily care composition comprises glycerin in an amount of 1 to 10 wt.-%, more preferably 2 to 8 wt.-% or 4 to 10 wt.-%, and in particular 5 to 8 wt.-%, based on the total weight of the sunscreen or daily care composition.

[0144] In a preferred embodiment, the sunscreen or daily care composition has an SPF value (according to EC recommendation) of 6 to 50+, the SPF being determined in-vivo or in-vitro or by bioinformatics (e.g. with the Sunscreen Simulator, https: / / sunscreensimulator.basf.com / ).

[0145] According to a preferred embodiment of the present application, the sunscreen or daily care composition does not contain 2-cyano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl ester (INCI Octocrylene), (RS)-(2E)-3-(4-methoxyphenyl)prop-2-enoic acid 2- ethylhexyl ester (INCI Methoxy cyminat ethylhexyl), (2E)-3-(4-methoxyphenyl)prop-2- enoic acid 3-methylbutyl ester (INCI Isoamyl p-methoxy cinnamate), and / or Homosalate. These UV filters have been identified to have a negative impact on human health and / or the environment and are therefore preferably excluded from the compositions of the present application.

[0146] According to another embodiment, the sunscreen or daily care composition is for use in a method of protecting the skin microbiome from UV-A radiation and / or UV-B radiation, preferably from UV-A and UV-B radiation. The combination of UV filters present in the sunscreen or daily care composition for use in the present application is capable of well protecting the skin microbiome from UV-A and / or UV-B radiation.

[0147] It is understood that the above embodiments of the sunscreen or daily care composition also apply to the second and third aspects of the present application, in particular with regard to the at least one additional UVB filter, the at least one micronized UV filter, the at least one additional UVA filter, the further ingredients (such as emulsifiers, thickeners, emollients, organoleptic enhancers, adjuvants, preservatives, and / or fragrances), and the amounts / weight ratios in the sunscreen or daily care composition.

[0148] The second aspect of the application relates to a sunscreen or daily care composition for use in a method of increasing the activity of the skin microbiome under UV light irradiation, comprising

[0149] - a first UV filter, wherein the first UV filter is 2-[4-(diethylamino)-2- hydroxybenzoyl]benzoic acid hexyl ester (INCI Diethylamino Hydroxybenzoyl Hexyl Benzoate); and

[0150] - a second UV filter, wherein the second UV filter is selected from the group consisting of (tris(2-ethylhexyl)-4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyl Triazone), 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine), and mixtures thereof.

[0151] The term “increasing the activity of the skin microbiome under UV light irradiation” means herein that UV light irradiation on a sample of the sunscreen or daily care composition of the application leads to a less reduction of the skin microbiome microbial colonies compared to the exact same composition of the sunscreen or daily care composition of the application (not comprising the specific UV filter combination). When comparing two compositions, a first composition comprising the UV filter combination according to the application and a second composition having the same components but not the specific UV filter combination, the difference in reduction of the colonies of the skin microbiome microorganisms is at least 10%, preferably at least 20%, more preferably at least 50% and most preferably at least 90% in terms of number of colonies. The second composition can be free of any UV filter or comprise a different UV filter combination.

[0152] By first controlling the viability of the microorganisms in the dark without any UV irradiation and then testing the viability of the microorganisms of the skin microbiome when applying UV light irradiation, preferably with 10 J / cm 2 of UVA irradiation and 40 mJ / cm 2 of UVB irradiation. The number of colonies is determined as CFU / ml (CFU = colony forming units). Further details of the method for determining the viability of the microorganisms according to the application are outlined in the examples.

[0153] A third aspect of the present application relates to a UV filter combination of hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI Diethylamino Hydroxybenzoyl Hexyl Benzoate) with 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis- Ethylhexyloxyphenol Methoxyphenyl Triazine) and / or (tris(2-ethylhexyl)-4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyl Triazone) for use in a method of protecting the skin microbiome from UV radiation.

[0154] Also described is a method of protecting the skin microbiome from damage by UV light exposure by applying on the skin a sunscreen or daily care composition comprising

[0155] - a first UV filter,

[0156] wherein the first UV filter is hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI Diethylamino Hydroxybenzoyl Hexyl Benzoate); and

[0157] - a second UV filter,

[0158] wherein the second UV filter is selected from the group consisting of (tris(2- ethylhexyl)-4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyl Triazone), 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine), and mixtures thereof.

[0159] Also described is the use of a sunscreen or daily care composition for protecting the skin microbiome from damage by UV light exposure, the sunscreen or daily care composition comprising

[0160] - a first UV filter,

[0161] wherein the first UV filter is hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI Diethylamino Hydroxybenzoyl Hexyl Benzoate); and

[0162] - a second UV filter,

[0163] wherein the second UV filter is selected from the group consisting of (tris(2- ethylhexyl)-4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino)triphenylcarboxylate) (INCI Ethylhexyl Triazone), 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4- methoxyphenyl)-1,3,5-triazine (INCI Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine), and mixtures thereof.

[0164] The method and use also relate to the same sunscreen or daily care composition as used in the aspects of the application.

[0165] Examples

[0166] The application is further illustrated by the following examples.

[0167] Evaluation of the SPF

[0168] The SPF values were calculated using the Basf Sunscreen Simulator (https: / / sunscreensimulator.basf.com / ).

[0169] Determination of the effect of the sunscreen composition to protect the skin microbiome bacteria from UV irradiation

[0170] Bacteria:

[0171] S. hominis, S. epidermidis and C. acnes were used as bacterial strains of the skin microbiome. S. epidermidis strain ATCC 12228 and S. hominis ATCC 27844 were obtained from the Pasteur Institute, France. These strains were grown in tryptic soy agar and tryptic soy broth (Biomérieux, France) under aerobic conditions. C. acnes ATCC 11828 was obtained from the Pasteur Institute, France. This strain was grown in Schaedler agar supplemented with 5% sheep blood or Schaedler broth supplemented with 0.5 g / L of vitamin K3 (Biomérieux, France) under anaerobic conditions.

[0172] Test design:

[0173] Colony of S. epidermidis or S. hominis was inoculated in tryptic soy broth and incubated at 37°C for 24h under continuous agitation at 150 rpm.

[0174] Afterwards, 10 4UFC / ml of S. epidermidis and 10 3 UFC / ml of S. hominis suspension.

[0175] For P. acnes, the colonies were inoculated in tryptone soya broth supplemented with vitamin K3 (0.5 g / L) at 37°C without stirring for 72 h. Thereafter, 10 4 UFC / ml of P. acnes suspension.

[0176] 100 μΐ of these bacterial suspensions were spread on Petri dishes containing trypticase soy agar for staphylococcal species and Joyce agar for P. acnes. Then, 100 μΐ of the formulation to be tested were spread on the Petri dishes previously spread with bacteria. The Petri dishes were placed in the dark or in an irradiation chamber for UV irradiation conditions. The irradiation consisting of 10 J / cm 2 of UVA (320-400 nm) and 40 mJ / cm 2 of UVB (290-320 nm) was applied to the Petri dishes for UV irradiation conditions. Then, the Petri dishes were placed in an incubation chamber at a temperature of 37°C for 24 h for S. hominis, 48 h for S. epidermidis and 96 h for P. acnes under aerobic conditions.

[0177] Evaluation:

[0178] Thereafter, the colonies were counted and the CFU / ml for each test condition was determined. Each sample was measured in quadruplicate. Statistical analysis was performed using the Mann-Whitney rank sum test, wherein p < 0.05 was determined as statistically significant difference.

[0179] Composition:

[0180] Formulations 1 to XY were manufactured as follows:

[0181] The ingredients of the A and B parts provided were separated, combined, heated to 80°C while stirring, respectively. Subsequently, the A part was added to the B part while stirring and the combined mixture was then homogenized using an ultra turrax type homogenizer. The homogenized mixture was cooled to approximately 30°C and then the pH was adjusted to about 6.

[0182] The overall composition of the formulations tested is shown in Table 1

[0183]

[0184]

[0185] Table 1 : Formulation vehicles used to test the effect of UV irradiation on microbial survival; amounts in wt.% based on the total weight of the formulation

[0186] For the control formulation without UV filters ("composition without UV filters"), the amount of the formulation attributed to the "UV filter combination" was replaced by water.

[0187] The abbreviations of the UV filters are used in the following way:

[0188] - 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester (INCI diethylamino hydroxybenzoyl hexyl benzoate) is "DHHB"

[0189] - tris(2-ethylhexyl)-4,4',4"-(1,3,5-triazine-2,4,6-triyl triimino) tricarboxylate (INCI ethylhexyl triazone) is "EHT"

[0190] - 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI bis-ethylhexyloxyphenyl methoxyphenyl triazine) is "BEMT"

[0191] - 1 -(4-(1,1 -dimethylethyl)phenyl)-3-(4-methoxyphenyl)propane-1,3-dione (INCI butyl methoxydibenzoylmethane) is "BMDBM"

[0192] - 2-ethylhexyl 2-hydroxybenzoate (INCI ethylhexyl salicylate) is "EHS"

[0193] For S. epidermidis the following UV filter combinations 2a-1 to 2a-4 shown in Table 2a were tested:

[0194]

[0195] Table 2a: UV-filter combinations used in the formulations shown in Table 1 ; wt.% is based on the total weight of the formulation of Table 1 ; inv = inventive UV filter combination; comp = comparative UV filter combination

[0196] Table 3a and Figure 1 It is shown that from each formulation (formulations 2a-1 to 2a-4) either without any irradiation step (dark conditions) or after UV irradiation (UVA 10 J / cm 2 and UVB 40 mJ / cm 2) measured from four measurements (N1-N4) obtained with Staphylococcus epidermidis. The composition without any UV filter protection reduced the number of Staphylococcus epidermidis colonies by 100% under UV irradiation, i.e. all colonies were destroyed by the damaging effect of the irradiation. In comparison to the two comparative formulations 2a-2 and 2a-4 comprising DHHB and EHT, or DHHB and BEMT, respectively, the inventive formulations 2a-1 and 2a-3 comprising DHHB and EHT, or DHHB and BEMT, respectively, achieved a statistically significantly higher viability of Staphylococcus epidermidis under irradiation conditions. This effect was particularly pronounced for the combination of EHT and DHHB as UV filters (formulation 2a-1).

[0197]

[0198] Table 3a: Number of Staphylococcus epidermidis colonies in CFU / ml when combined with different cosmetic formulations under no UV irradiation conditions and with UV irradiation conditions; inv = inventive; comp = comparative; SD = standard deviation

[0199] For Staphylococcus hominis the following UV filter combinations 2b-1 to 2b-2 shown in Table 2b were tested:

[0200]

[0201] Table 2b: UV-filter combinations used in the formulations shown in Table 1 ; wt.% is based on the total weight of the formulations of Table 1 ; inv = inventive UV filter combination; comp: comparative UV filter combination

[0202] Table 3b and Figure 2 shows the results of Staphylococcus hominis measured from four measurements (N1-N4) obtained with each formulation (formulations 2b-1 to 2b-2) without any irradiation step (dark conditions) or after UV irradiation (UVA 10 J / cm 2 and UVB 40 mJ / cm 2 ). In case of the inventive formulation 2b-1 the number of colonies was almost the same after UV irradiation as without UV irradiation, which proves how effective the UV filter combination of DHHB and EHT of the present invention is in protecting the skin microbiome from the damaging effects of UV irradiation. In contrast, for the comparative formulation with BMDBM and EHT a significant decrease in the viability of Staphylococcus hominis colonies was observed in the UV irradiation assay.

[0203]

[0204] Table 3b: Number of human Staphylococcus aureus colonies in CFU / ml when combined with different cosmetic formulations under conditions without UV irradiation and with UV irradiation; inv = the invention; comp = comparative; SD = standard deviation

[0205] For P. acnes the following UV filter combinations 2c-1 to 2c-3 shown in Table 2c were tested:

[0206]

[0207] Table 2c: UV-filter combinations used in the formulations shown in Table 1 ; wt.% is based on the total weight of the formulation of Table 1 ; inv = UV filter combination of the invention; comp: comparative UV filter combination

[0208] Table 3c and Figure 3 The results for P. acnes obtained from four measurements (N1-N4) measured from each formulation (formulations 2b-1 to 2b-2) without any irradiation step (dark conditions) or after UV irradiation (UVA 10 J / cm 2 and UVB 40 mJ / cm 2 ) are shown. Again, the combination of EHT and DHHB proved to be highly effective in protecting the microbiome bacteria (here: P. acnes) from UV irradiation. In contrast, the comparative formulation 2c-2 comprising EHT and BMDBM as UV filters showed a loss of colony numbers of more than 90% (number of colonies from more than 10 3 in the dark to less than 10 2 under UV irradiation). In case of the comparative formulation 2c-3 comprising EHS and DHHB, the viability of P. acnes under UV irradiation was also low. Interestingly, for this UV filter combination, there was also a lack of compatibility with the microorganism before UV irradiation, as evident from the results in the dark, which already showed a significant decrease in P. acnes viability compared to the control formulation composition without UV filter.

[0209]

[0210] Table 3c: Number of P. acnes colonies in CFU / ml when combined with different cosmetic formulations under conditions without UV irradiation and with UV irradiation; inv = the invention; comp = comparative; SD = standard deviation

[0211] The results from Examples 2a to 2c show that the UV filter combination of DHHB and EHT, or DHHB and BEMT of the present application is highly effective in protecting the skin microbiome from the damaging effects of UV irradiation. The differences in Examples 2a to 2c are all statistically significant. The effects on the skin microbiome are exemplified herein by three different types of bacteria (Staphylococcus epidermidis, Staphylococcus hominis, Propionibacterium acnes). Sunscreen or daily care compositions comprising this UV filter combination exhibit a higher level of protection for the skin microbiome from UV irradiation compared to the comparative sunscreen compositions with other UV filter combinations investigated. Furthermore, the sunscreen compositions of the present application are compatible with the microorganisms of the skin microbiome.

[0212] In summary, the compositions of the present application are highly suitable for protecting the skin microbiome from the deleterious effects of UV irradiation.

Claims

1. A sunscreen or daily care composition for use in a method for protecting the skin microbiome from damage by UV light exposure, comprising - first UV filter, wherein the first UV filter is 2-[4-(diethylamino)-2-hydroxybenzoyl] benzoic acid hexyl ester (INCI Diethylamino Hydroxybenzoyl Hexyl Benzoate); and - a second UV filter, wherein the second UV filter is selected from the group consisting of: (tris(2-ethylhexyl)-4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino) tribenzoate) (INCI Ethylhexyl Triazone), 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine), and mixtures thereof.

2. The sunscreen or daily care composition according to claim 1, wherein The sunscreen or daily care composition is used in a method for protecting a bacterial population in the skin microbiome from damage by UV light exposure selected from the group consisting of: Propionibacterium acnes, Propionibacterium granulosum, Propionibacterium voracious, Staphylococcus epidermidis, Staphylococcus saprophyticus, Staphylococcus hominis, Staphylococcus xylosus, Staphylococcus woerneri, Staphylococcus haemolyticus, Staphylococcus saccharolyticus, Staphylococcus cohnii, Staphylococcus auris, Micrococcus luteus, Corynebacterium minimus, Corynebacterium jejuni, Corynebacterium tuberculostearic acid, Corynebacterium congestum, Corynebacterium pseudomycoticum, Corynebacterium dry, Streptococcus mitis, Streptococcus sanguis, Streptococcus oralis, Brevibacterium species, Pseudomonas species, and mixtures thereof, preferably Staphylococcus hominis, Staphylococcus epidermidis, Propionibacterium acnes, and mixtures thereof, and / or wherein the sunscreen or daily care composition is used in a method for protecting a fungal population in the skin microbiome from damage by UV light exposure selected from the group consisting of: Malassezia furfur, furfur), Malassezia restricta, Malassezia globosa, Candida spp., and mixtures thereof.

3. The sunscreen or daily care composition according to any one of claims 1 or 2, wherein The sunscreen or daily care composition further comprises at least one additional UVB filter or broadband filter, preferably selected from the group consisting of: bis(2-ethylhexyl)-4,4'-[[6-[[4-[[(1,1-dimethylethyl)amino]carbonyl]phenyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-benzoate (INCI Diethylhexyl Butamido Triazone or DBT), phenyl-3H-benzimidazole-5-sulfonic acid (INCI Phenyl benzimidazole sulfonic acid), diethyl dimethicone benzylmalonate (INCI Polysilicone-15), 2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1-disiloxanyl]propyl]phenol (INCI Drometrizole Trisiloxane), and mixtures thereof, and in particular phenyl-3H-benzimidazole-5-sulfonic acid (INCI Phenylbenzimidazole Sulfonic Acid or PBSA).

4. The sunscreen or daily care composition according to any one of claims 1 to 3, wherein The sunscreen or daily care composition further comprises at least one organic micronized UV filter selected from the group consisting of: 2,2'-methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol] (INCI Methylene Bis-Benzotriazolyl Tetramethylbutylphenol), 2,4,6-Tris(biphenyl-4-yl)-1,3,5-triazine (INCI Tris-Biphenyl Triazine), 5,6,5',6'-tetraphenyl-3-(3'-phenylene)bis(1,2,4-triazine) (INCI Phenylene 1-[2-[4-(diethylamino)-2-hydroxybenzoyl]phenyl]-methanone (INCI Bis-(diethylaminohydroxybenzoylbenzoyl)piperazine), preferably 2,2'-methylenebis[4-(1,1,3,3-tetramethylbutyl)-6-(2H-benzotriazol-2-yl)phenol] (INCI Methylenebis-Benzotriazolyltetramethylbutylphenol) and / or 2,4,6-Tris(biphenyl-4-yl)-1,3,5-triazine (INCI Tris-Biphenyl Triazine).

5. The sunscreen or daily care composition according to claim 4, wherein The at least one organic micronized UV filter is not dispersed in (3R,4S,5S,6R)-2-(decyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (INCI Decyl Glucoside) and / or wherein the at least one organic micronized UV filter is dispersed in a polyglycerol monoalkyl ester.

6. The sunscreen or daily care composition according to any one of claims 1 to 5, wherein The sunscreen or daily care composition further comprises at least one additional UVA filter, preferably selected from the group consisting of [(3Z)-3-[[4-[(Z)-[7,7-dimethyl-2-oxo-1-(sulfomethyl)-3-bicyclo[2.2.1]heptylene]methyl]phenyl]methylene]-7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptyl]methanesulfonic acid (INCI Terephthalidene Dicamphorsulfonic Acid), Disodium Phenyldibenzimidazole Tetrasulfonate, 1-(4-(1,1-dimethylethyl)phenyl)-3-(4-methoxyphenyl)propane-1,3-dione (INCI Butyl Methoxydibenzoylmethane), and mixtures thereof, in particular 1-(4-(1,1-dimethylethyl)phenyl)-3-(4-methoxyphenyl)propane-1,3-dione (INCI Butyl Methoxydibenzoylmethane).

7. The sunscreen or daily care composition according to any one of claims 1 to 6, wherein The sunscreen or daily care composition does not contain zinc oxide (ZnO).

8. The sunscreen or daily care composition according to any one of claims 1 to 7, wherein The sunscreen or daily care composition comprises 2-[4-(diethylamino)-2-hydroxybenzoyl] hexyl benzoate (INCI Diethylamino Hydroxybenzoyl Hexyl Benzoate) in an amount of 0.1 to 10.0 wt.-%, preferably 0.5 to 8.0 wt.-%, and in particular 1.0 to 5.0 wt.-%, based on the total weight of the sunscreen or daily care composition, and / or the sunscreen or daily care composition comprises 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine) in an amount of 0.1 to 7.0 wt.-%, preferably 0.5 to 4.0 wt.-%, and in particular 1.0 to 3.0 wt.-%, based on the total weight of the sunscreen or daily care composition.

9. The sunscreen or daily care composition according to any one of claims 1 to 8, wherein The sunscreen or daily care composition comprises (tris(2-ethylhexyl)-4,4′,4″-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate) (INCI Ethylhexyl Triazone) in an amount of 0.1 to 5.0 wt.-%, preferably 0.5 to 4.0 wt.-%, based on the total weight of the sunscreen or daily care composition.

10. The sunscreen or daily care composition according to any one of claims 1 to 9, wherein The sunscreen or daily care composition further comprises a dermatologically acceptable emulsifier, thickener, and / or emollient.

11. The sunscreen or daily care composition according to any one of claims 1 to 10, wherein The sunscreen or daily care composition does not contain 2-ethylhexyl 2-cyano-3,3-diphenylprop-2-enoate (INCI Octocrylene), 2-ethylhexyl (RS)-(2E)-3-(4-methoxyphenyl)prop-2-enoate (INCI Ethylhexyl Methoxycinnamate), 3-methylbutyl (2E)-3-(4-methoxyphenyl)prop-2-enoate (INCI Isoamyl p-Methoxycinnamate), and / or homosalate.

12. The sunscreen or daily care composition according to any one of claims 1 to 11, wherein The sunscreen or daily care composition is used to protect the skin microbiome from UV-A radiation and / or UV-B radiation.

13. A sunscreen or daily care composition for use in a method of increasing the viability of the skin microbiome under UV light irradiation, comprising - first UV filter, wherein the first UV filter is 2-[4-(diethylamino)-2-hydroxybenzoyl] benzoic acid hexyl ester (INCI Diethylamino Hydroxybenzoyl Hexyl Benzoate); and - a second UV filter, wherein the second UV filter is selected from the group consisting of: (tris(2-ethylhexyl)-4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino) tribenzoate) (INCI Ethylhexyl Triazone), 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine), and mixtures thereof.

14. A UV filter combination of 2-[4-(diethylamino)-2-hydroxybenzoyl] benzoic acid hexyl ester (INCI Diethylamino Hydroxybenzoyl Hexyl Benzoate) and 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine) and / or (Tris(2-ethylhexyl)-4,4',4"-(1,3,5-triazine-2,4,6-triyltriimino) tribenzoate) (INCI Ethylhexyl Triazone) for use in a method for protecting the skin microbiome from UV radiation.

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