Composition with skin whitening, brightening and soothing effects, skin product and preparation method of skin product

Abstract

The invention relates to a composition with skin whitening, brightening and soothing effects, a skin product and a preparation method of the skin product. The composition is prepared from hydrolyzed corn protein, bis-diethoxy diethylene glycol cyclohexane 1, 4-dicarboxylate, kappaphycus alvarezii extract and aminoethyl phosphinic acid according to the weight ratio of (0.1 to 5) to (0.5 to 2) to (0.3 to 1.5) to (0.5 to 1.5). Compared with the prior art, the composition has the advantages that through special selection of the functional composition, tyrosinase activity is inhibited, oxidation reaction in the melanogenesis process is inhibited, stimulation of ultraviolet rays to melanin cells is weakened, melanin generation is reduced, formation of melanin and color spots is inhibited through multi-aspect synergism, chromatosis is prevented, and the effect is remarkable. The skin whitening mask has the effects of whitening and brightening the skin color, and the keratinocyte morphology is better protected by increasing the formation of a keratinocyte envelope, so that the keratinocyte envelope is more full, more compact in arrangement and better in barrier function.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of daily chemicals, in particular relates to a composition with whitening and skin lightening and soothing effects, a skin product and a preparation method thereof. BACKGROUND

[0002] At present, there are many products on the market for whitening and skin lightening, but the whitening agents in these products are mainly niacinamide, vitamin C derivatives, and phenylethyl resorcinol, which only have a single whitening function or a combination of several different whitening agents. These whitening agents are often used in cosmetics, but their whitening effect is not satisfactory. In addition, there are other problems when these whitening agents are added to cosmetics, such as instability of the raw materials, difficulty in adding them to the cosmetic formulation system, easy discoloration, or high skin irritation, leading to a high rate of allergies.

[0003] For skin care or cosmetic products, skin absorbability is an important evaluation dimension. Generally, skin care or cosmetic products contain penetration enhancers to improve their skin absorbability. The commonly used penetration enhancer is azone, which increases the diffusion depth of active ingredients by dissolving the lipid in the stratum corneum or liquefying the lipid in the stratum corneum cells. Azone has strong destructive effect on the stratum corneum, and long-term use can cause loss of the stratum corneum and damage to the barrier function of the stratum corneum. Therefore, it is difficult to find a safe and effective penetration system.

[0004] Chinese patent application No. 202211188128.6 discloses a cosmetic raw material composition with whitening and soothing effects and an evaluation system thereof. The preparation raw materials of the cosmetic raw material composition with whitening and soothing effects include the following ingredients: Radix Glycyrrhizae, Curcuma longa root extract, Radix Scutellariae, Radix Paeoniae, and Radix Notoginseng extract. The total concentration of Radix Glycyrrhizae is 5%, the total concentration of Curcuma longa root extract is 5%, the total concentration of Radix Scutellariae is 26%, the total concentration of Radix Paeoniae is 11%, and the total concentration of Radix Notoginseng extract is 53%. The composition combines multiple natural cosmetic raw materials, whitens the skin, soothes the skin, protects the skin from external irritation, and has good whitening and soothing effects on the skin. The combined raw materials have better effects than single components and have a good synergistic effect. A multi-dimensional evaluation system is established for the combined raw materials and cosmetics containing the raw materials. However, the composition used in this scheme has many types, high cost, and complicated process, and the content of the composition in the cosmetic is high, which also has a certain burden on the skin. SUMMARY

[0005] To overcome the problems of the whitening and soothing composition in the prior art described in the background art, the present application provides a composition with whitening and soothing effects, a skin product and a preparation method thereof.

[0006] The composition with whitening and soothing effects provided by the present application can inhibit tyrosinase activity, inhibit the oxidation reaction of the melanin production process, weaken the stimulation of ultraviolet rays on melanocytes, and reduce the production of melanin. The scheme of the present application can inhibit the formation of melanin and pigmented spots through multi-aspect synergy, prevent pigmentation, and have the effects of whitening and lightening skin color. Further, the scheme can better protect the keratinocyte form by increasing the formation of keratinization envelope. The keratinization envelope is more full and closely arranged, and the barrier function is better. Therefore, the scheme provided by the present application has the effects of whitening and soothing, and also has a certain skin barrier function.

[0007] The object of the present application can be achieved by the following technical solutions.

[0008] The present application provides a composition with whitening and soothing effects, which comprises hydrolyzed corn protein, bis-diethoxydiglycol cyclohexane 1,4-dicarboxylic acid ester, long heart kappa seaweed extract and aminoethyl phosphinic acid.

[0009] In an embodiment of the present application, the weight ratio of the hydrolyzed corn protein, bis-diethoxydiglycol cyclohexane 1,4-dicarboxylic acid ester, long heart kappa seaweed extract and aminoethyl phosphinic acid is (0.1-5):(0.5-2):(0.3-1.5):(0.5-1.5).

[0010] In an embodiment of the present application, the weight ratio of the hydrolyzed corn protein, bis-diethoxydiglycol cyclohexane 1,4-dicarboxylic acid ester, long heart kappa seaweed extract and aminoethyl phosphinic acid is (0.5-3.0):(1-2):(0.5-1):(0.5-1.2). Further preferably, the weight ratio of the hydrolyzed corn protein, bis-diethoxydiglycol cyclohexane 1,4-dicarboxylic acid ester, long heart kappa seaweed extract and aminoethyl phosphinic acid is 0.5:1:0.5:0.5.

[0011] In an embodiment of the present application, the composition with whitening and soothing effects is composed of hydrolyzed corn protein, bis-diethoxydiglycol cyclohexane 1,4-dicarboxylic acid ester, long heart kappa seaweed extract and aminoethyl phosphinic acid, and the weight ratio of the hydrolyzed corn protein, bis-diethoxydiglycol cyclohexane 1,4-dicarboxylic acid ester, long heart kappa seaweed extract and aminoethyl phosphinic acid is (0.1-5):(0.5-2):(0.3-1.5):(0.5-1.5).

[0012] The present application further provides use of the composition having whitening and soothing effects in the preparation of a skin product.

[0013] The skin product includes skin care products and cosmetics, and is not limited to some specific dosage forms, and can be prepared as skin toner, nutrient cosmetic water, massage cream, nutrient cream, mask, serum, ointment, color cosmetic base, foundation cream, emulsion (oil-in-water or water-in-oil), jelly, cream, spray, etc. according to needs. Preferably, the skin product is selected from serum, emulsion, cream, lyophilized powder or skin toner.

[0014] In one embodiment of the present application, the composition having whitening and soothing effects in the skin product is 0.4-9.5% by weight.

[0015] The present application further provides a skin product having whitening and soothing effects, wherein the composition having whitening and soothing effects is 0.4-9.5% by weight.

[0016] In one embodiment of the present application, the skin product further comprises a cosmetically acceptable carrier.

[0017] In one embodiment of the present application, the cosmetically acceptable carrier refers to a carrier that makes the skin product applicable, and is selected from one or more of solvents, thickening agents, skin conditioning agents, humectants, emulsifiers, esterifying agents, pH regulators, fragrances or preservatives. For example, but not limited to, deionized water, 1,2-hexanediol, p-hydroxyacetophenone, butanediol, panthenol, dipotassium glycyrrhizinate, arginine, glycerol, betaine, sodium hyaluronate, propylene glycol, glyceryl stearate / PEG-100 stearate, glyceryl stearate, xanthan gum, hydroxyethyl cellulose, carbomer, disodium EDTA, isohexadecane, isooctyl palmitate, cetostearyl alcohol, dimethicone, citric acid or its salt, behenyl alcohol, behenyl alcohol polyether, cetyl alcohol polyether, pentaerythritol tetra(ethylhexanoate), squalane, cetyl alcohol ethylhexanoate, etc.

[0018] In one embodiment of the present application, the skin product is in the form of solvent dispersion or suspension, or emulsified particles, or polymer-coated.

[0019] In one embodiment of the present application, the skin product with whitening and soothing effect is a cream with whitening and soothing effect, and the cream raw materials, with a total weight of 100%, comprise the following components in the following weight percentages: 0.4-9.5% of the composition with whitening and soothing effect, 15-25% of emollients, 4-6% of emulsifiers, 0.01-1% of fillers, 0.5-2% of thickening agents, 0.8-1.5% of preservatives, 0.02-0.2% of fragrances, 0.1-10% of skin conditioning agents, 0.1-10% of humectants, and the rest is deionized water.

[0020] In one embodiment of the present application, the skin product with whitening and soothing effect is a cream with whitening and soothing effect, and the cream raw materials, with a total weight of 100%, comprise the following components in the following weight percentages: 0.4-9.5% of the composition with whitening and soothing effect, 15-25% of emollients, 4-6% of emulsifiers, 0.01-1% of fillers, 0.5-2% of thickening agents, 0.8-1.5% of preservatives, 0.02-0.2% of fragrances, 0.1-10% of skin conditioning agents, 0.1-10% of humectants, and the rest is deionized water.

[0021] In one embodiment of the present application, the emollients are selected from one or more of behenyl alcohol, cetyl alcohol, caprylic / capric triglyceride, squalane, avocado oil, shea butter, jojoba esters, olive oil, dimethicone, dimethicone alcohol, isohexadecane, phytosteryl, cocoyl octanoate, or isononyl isononanoate.

[0022] In one embodiment of the present application, the emulsifiers are selected from one or more of polyglyceryl-3 methylglucose distearate, polyglyceryl-6 distearate, polyglyceryl-3 beeswaxate, potassium cetyl phosphate, methyl glucose sesquistearate, PEG-20 methyl glucose sesquistearate, steareth-21, cetyl stearyl alcohol, cetyl stearyl glucoside, glyceryl stearate, or PEG-100 stearate.

[0023] In one embodiment of the present application, the fillers are selected from one or more of boron nitride, synthetic fluorphlogopite, diatomaceous earth, kaolin, cellulose acetate, or starch octyl aluminometasilicate.

[0024] In one embodiment of the present application, the thickening agents are selected from one or more of carbomer, xanthan gum, acrylates / C10-30 alkyl acrylate crosspolymer, gum arabic, polymer EMT-10, sodium acrylate / sodium acryloyldimethyl taurate, acrylates / C10-30 alkyl acrylate crosspolymer copolymer, hydroxyethyl cellulose, agarose, or hectorite.

[0025] In one embodiment of the present application, the preservative is selected from one or more of phenoxyethanol, ethylhexylglycerin, farnesyl ketone, sodium benzoate or hexylene glycol, it is to be noted that the amount of preservative used should meet the cosmetic safety limit when different substances are selected;

[0026] In one embodiment of the present application, the skin conditioning agent is selected from allantoin.

[0027] In one embodiment of the present application, the humectant is selected from one or more of 1,2-pentanediol or sodium hyaluronate.

[0028] The present application further provides a method for preparing the skin product with whitening, lightening and soothing effects, which comprises the step of mixing the composition with whitening, lightening and soothing effects as described above and a cosmetically acceptable carrier to obtain the skin product with whitening, lightening and soothing effects.

[0029] In one embodiment of the present application, the skin product with whitening, lightening and soothing effects is a cream with whitening, lightening and soothing effects, and the method for preparing the cream with whitening, lightening and soothing effects comprises the following steps:

[0030] 1) Disperse the thickening agent in deionized water until completely wetted to obtain a mixture, and then add the humectant and stir until uniform for use;

[0031] 2) Add the emollient, filler and emulsifier to the mixture in step 1) and heat to 80-85℃, and then homogenize at 2000-3500 r / min for 3-5 minutes until completely emulsified;

[0032] 3) Cool to 43-45℃, and then add the preservative, skin conditioning agent, composition with whitening, lightening and soothing effects and fragrance to the mixture in step 2) to obtain the cream with whitening, lightening and soothing effects.

[0033] Compared with the prior art, the present application has the following advantages and beneficial effects:

[0034] 1、The application selects hydrolyzed corn protein, long heart kappa seaweed extract and aminoethyl phosphinic acid as whitening, brightening and soothing functional ingredients, and selects bis-diethoxydiglycol cyclohexane 1,4-dicarboxylic acid ester as a penetration enhancer, which can better promote the absorption of the three functional ingredients hydrolyzed corn protein, long heart kappa seaweed extract and aminoethyl phosphinic acid by the skin, achieving better results. The four ingredients synergize to inhibit tyrosinase activity, inhibit the oxidation reaction of the melanin generation process, weaken the stimulation of ultraviolet rays on melanocytes, reduce the generation of melanin, and inhibit the formation of melanin and color spots in multiple ways, having the effects of preventing pigmentation, whitening and brightening skin color. In addition, the composition provided by the application also has the effect of increasing the formation of keratinization envelope, which better protects the morphology of keratinocytes, the keratinization envelope is fuller, the arrangement is tighter, and the barrier function is better.

[0035] 2、The water-oil amphiphilic high-efficiency penetration enhancer bis-diethoxydiglycol cyclohexane 1,4-dicarboxylic acid ester used in the application can penetrate deep into intercellular lipids, temporarily open the channel, promote the penetration effect of water-soluble active ingredients, and also reduce the solubility of water-soluble ingredients, so that they can better enter the stratum corneum and synergistically enhance the effects of the functional ingredients (hydrolyzed corn protein, long heart kappa seaweed extract and aminoethyl phosphinic acid), achieving better skin lightening effects. BRIEF DESCRIPTION OF DRAWINGS

[0036] Figure 1 The detection results of skin melanin content of the subject using example 1 after 56 days;

[0037] Figure 2 The skin melanin change rate of the subject using example 1 after 56 days;

[0038] Figure 3 The detection results of skin glossiness of the subject using example 1 after 56 days;

[0039] Figure 4 The skin glossiness change rate of the subject using example 1 after 56 days. DETAILED DESCRIPTION

[0040] The application provides a composition with whitening, brightening and soothing effects, which comprises hydrolyzed corn protein, bis-diethoxydiglycol cyclohexane 1,4-dicarboxylic acid ester, long heart kappa seaweed extract and aminoethyl phosphinic acid, and the weight ratio of hydrolyzed corn protein, bis-diethoxydiglycol cyclohexane 1,4-dicarboxylic acid ester, long heart kappa seaweed extract and aminoethyl phosphinic acid is (0.1-5):(0.5-2):(0.3-1.5):(0.5-1.5).

[0041] Among them, the hydrolyzed corn protein mainly plays a role in promoting the keratinization envelope precursor, increasing the expression of the envelope protein, filaggrin, keratin, and cuticular protein, and increasing the formation of the keratinization envelope, thereby better protecting the morphology of the keratinocyte. The keratinization envelope is more full, the arrangement is more compact, and the barrier function will be better.

[0042] Bis-diethoxydiglycol cyclohexane 1,4-dicarboxylate can penetrate into intercellular lipids, temporarily open the channel, promote the penetration of water-soluble active ingredients, and also reduce the solubility of water-soluble ingredients, so that they can better enter the stratum corneum and synergistically enhance the efficacy ingredients.

[0043] The long heart kappa algae extract has a super strong ability to resist ultraviolet rays, can weaken the stimulation of ultraviolet rays on melanocytes, reduce the generation of melanin, and inhibit the biosynthesis of tyrosinase to reduce the generation of melanin.

[0044] Aminoethyl phosphinic acid is a dopachrome stabilizer that can inhibit the next reaction of dopachrome and generate 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole-2-carboxylic acid (DHICA), thereby inhibiting the generation of melanin. The specific principle is as follows: tyrosine is generated under the catalysis of tyrosinase L-dihydroxyphenylalanine (L-DOPA), and further generates dopaquinone (DQ) under the action of tyrosinase, or tyrosine is directly oxidized to generate dopaquinone under the catalysis of tyrosinase. Dopaquinone as a melanin synthesis substrate enters the second stage reaction. The second stage is divided into three parts. When cysteine or glutathione exists, dopaquinone reacts with it to generate cysteine dopa or glutathione dopa, and then further oxidizes and polymerizes to generate pheomelanin; when the two do not exist, dopaquinone cyclizes to form dopachrome, and if dopachrome spontaneously decarboxylates, 5,6-dihydroxyindole (DHI) is formed, which is further oxidized and polymerized to generate melanin (DHI melanin) under the action of tyrosinase; if dopachrome undergoes a phenomenon of mutual transformation under the action of TRP-2 to form DHICA, then under the action of TRP-1, melanin (DHICA melanin) is generated.

[0045] The application innovatively compounds several functional components, multiplies the effects, inhibits the activity of tyrosinase, inhibits the oxidation reaction of the melanin generation process, weakens the stimulation of ultraviolet rays on melanocytes, reduces the generation of melanin, the scheme of the application inhibits the formation of melanin and color spots from multiple aspects, prevents pigmentation, has the effects of whitening and brightening skin color, and further increases the formation of keratinization envelope to better protect the morphology of keratinocytes, the keratinization envelope is more full, the arrangement is more compact, and the barrier function is better. Therefore, the scheme provided by the application has the effects of whitening and brightening skin, soothing, and repairing skin barrier.

[0046] Although numerical ranges and parameters are provided with specific values, those skilled in the art, upon reading the present application, will recognize that the numerical parameters set forth in the detailed description are by way of example only, and that the application can be practiced with other values without departing from the scope of the application. Those skilled in the art will recognize or be able to ascertain using no more than routine experimentation, the implied functional equivalents of structural modifications to the application described herein. The application consists of all alternatives of these embodiments together with all equivalents and / or modifications of the application as would be ascertained by those skilled in the art using no more than routine experimentation.

[0047] Unless otherwise defined, scientific and technical terms used in this specification shall have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. Also, commonly-accepted meanings of terms should be understood to apply unless otherwise indicated for context. Unless otherwise indicated, singular forms of nouns are intended to include the plural forms of the nouns.

[0048] Theories and mechanisms described and disclosed herein, whether correct, sound, or complete, are not meant to restrict or limit the scope of the application to the precise configurations and techniques disclosed. The application as claimed can also be practiced with the occurrence of other theories and mechanisms, and the application is therefore not limited to any specific inventive concept or philosophy.

[0049] In this document, all features that are described in terms of a numerical range or a percentage range are intended to be construed as having been specifically disclosed and claimed in all possible subranges and individual numerical values within the range, including integers and fractions, unless otherwise indicated.

[0050] The application will be further described with reference to the following examples. It should be understood that these examples are intended to illustrate the application and are not intended to limit the scope of the application. The experimental methods in the following examples, unless otherwise specified, are generally carried out under conventional conditions or according to the conditions recommended by the manufacturer. Unless otherwise specified, all percentages, ratios, proportions, or parts are by weight. Unless otherwise specified, the following percentages (%) are mass percentages.

[0051] The application will be further described with reference to the following examples. It should be understood that these examples are intended to illustrate the application and are not intended to limit the scope of the application. The experimental methods in the following examples, unless otherwise specified, are generally carried out under conventional conditions or according to the conditions recommended by the manufacturer. Unless otherwise specified, all percentages, ratios, proportions, or parts are by weight. Unless otherwise specified, the following percentages (%) are mass percentages.

[0052] The raw materials or devices used in the following examples can be purchased from the raw material supply market if no special instructions are given.

[0053] Examples 1-3

[0054] A cream with whitening and soothing effects, the raw material component proportions of which are shown in Table 1 below.

[0055] Table 1 Raw material component proportions of Examples 1-3 (unit: mass%)

[0056]

[0057]

[0058] The preparation method of the cream containing the composition with whitening and soothing effects described above comprises the following steps:

[0059] 1) The thickening agent is completely wet dispersed in deionized water to obtain a mixture, and then the humectant is added and stirred uniformly for standby;

[0060] 2) The emollient, filler and emulsifier are added to the mixture in step 1), and heated to 80°C, and then homogenized at 3000 r / min for 3-5 minutes to completely emulsify;

[0061] 3) The temperature is lowered to 45°C, and the preservative, skin conditioner, composition with whitening and soothing effects, and daily fragrance are added to step 2) to obtain the cream with whitening and soothing effects.

[0062] To verify the effect of the efficacy component of the present application, Comparative Examples 1-8 are set, and the raw material component proportions of the creams of Comparative Examples 1-8 are shown in Table 2 below.

[0063] Table 2 Raw material component proportions of Comparative Examples 1-8 (unit: mass%)

[0064]

[0065]

[0066]

[0067] The preparation method of the cream of Comparative Examples 1-8 comprises the following steps:

[0068] 1) The thickening agent is completely wet dispersed in deionized water to obtain a mixture, and then the humectant is added and stirred uniformly for standby;

[0069] 2) The emollient, filler and emulsifier are added to the mixture in step 1), and heated to 80°C, and then homogenized at 3000 r / min for 3-5 minutes to completely emulsify;

[0070] 3) cooling to 45℃, adding preservatives, efficacy ingredients and daily fragrances to step 2) to obtain a face cream.

[0071] Example of effect verification test

[0072] 1. Safety test

[0073] Test samples: Examples 1-3 and Comparative Examples 1-8

[0074] Test subjects: 110 subjects aged 20-50 years old were selected and randomly divided into 11 groups, 10 people in each group.

[0075] Test method: A third-party testing organization was used to test safety. A suitable patch tester with an area not exceeding 50 mm 2 and a depth of about 1 mm was selected, and a closed patch test method was used. About 0.02-0.025 ml (g) of the test substance (face cream prepared in Examples 1-3 and Comparative Examples 1-8) was added to the patch tester. The patch tester was attached to the flexor of the forearm of the subject, and after 24 h, the test substance was removed. Skin reactions were observed at 0.5 h, 24 h and 48 h after removal, respectively, and the results were recorded according to the skin reaction grading standard in the "Cosmetic Safety Technical Specification 2015".

[0076] Table 3 is the patch test results

[0077] Note: Skin reaction grading standard;

[0078] 0: Negative reaction;

[0079] 1: Suspected reaction; only weak erythema;

[0080] 2: Weak positive reaction (erythema reaction); erythema, infiltration, edema, and possibly papules;

[0081] 3: Strong positive reaction (vesicle reaction); erythema, infiltration, edema, papules, and vesicles; the reaction can extend beyond the test area;

[0082] 4: Very strong reaction (fusion vesicle reaction); obvious erythema, severe infiltration, edema, fusion vesicles, and the reaction extends beyond the test area.

[0083] Table 3 Patch test results

[0084]

[0085]

[0086] The results show that the products of Examples 1-3 and Comparative Examples 1-8 have a score of 0 at 30 min, 24 h and 48 h, and no adverse reactions on the skin, indicating that the cream product involved in the present application is safe and non-irritating to the skin.

[0087] 2. Stability test

[0088] Test sample: Examples 1-3;

[0089] Test method: Internal control standard: observe the appearance color, pH for three months:

[0090] A: no change; B: very slight change, basically not perceived when compared with the standard sample; C: slight change, also perceived when compared with the standard sample; D: obvious change, perceived by consumers; E: severe change,

[0091] The standard sample is the product stored at 25°C;

[0092] Table 4 Stability test results (where W represents weeks, M represents months, and cycle represents -15°C to 50°C cycle)

[0093] Time 50℃ 40℃ 45℃ 25℃ 5℃ -15℃ Cycles Light 1W A A A A A A A A 2W A A A A A A A A 3W A A A A A A A A 4W A A A A A A A A 2M A A A A A A A A 3M A A A A A A A A

[0094] As can be seen from Table 4 above, the cream prepared in Examples 1-3 has no significant changes in color, viscosity and pH within three months under high and low temperature or light conditions, indicating that the cream of the present application has good stability.

[0095] 3. Efficacy test

[0096] Test sample: Examples 1-3, Comparative Examples 1-8, blank sample (no sample applied to the subjects);

[0097] Subjects: 120 healthy women (25-45 years old), divided into 12 groups, 10 people in each group; each group uses Examples 1-3, Comparative Examples 1-8 and no sample (blank sample).

[0098] Test area: the whole face of the subjects.

[0099] Method of use: the subjects apply the sample to the whole face twice a day, or do not apply any sample (blank sample), for 56 days. In the morning, first apply sunscreen products to the whole face, and then apply the sample (Examples 1-3, Comparative Examples 1-8) or do not apply any sample (blank sample).

[0100] Test results at the following four time periods: before using the sample (D0), 14 days after using the sample (D14), 28 days after using the sample (D28), and 56 days after using the sample (D56).

[0101] In the attached Figures 1-4 Example 1 is labeled "Sample" and the blank sample is labeled "Control".

[0102] 3.1 Evaluation of whitening effect

[0103] The test items are:

[0104] 1) Skin melanin measuring instrument MX18 is used to detect skin melanin;

[0105] 2) Skin color measuring instrument CL200 is used to detect skin glossiness;

[0106] 3) Skin color measuring instrument CR400 is used to detect skin color.

[0107] Test results:

[0108] As Figures 1-2 shown in Tables 5-6, the efficacy test results of the test samples are the average values of the test results of 10 subjects in each group. After using the samples for 56 days, the skin melanin of the subjects was tested (the smaller the measured value, the less the skin melanin content). The skin melanin value of the subjects using the blank sample increased significantly by 5.31%, while the skin melanin of the subjects using the sample of Example 1 increased only by 1.22%. This shows that the prepared whitening and brightening face cream can effectively reduce the generation of skin melanin.

[0109] Table 5 Detection results of skin melanin content

[0110]

[0111]

[0112] Table 6 Change rate of skin melanin after 56 days

[0113] Time After 14 days of use After 28 days of use After 56 days of use Example 1 -0.39％ 0.30％ 1.22％ Example 2 -0.50％ 0.22％ 0.94％ Example 3 -0.62％ 0.14％ 0.74％ Comparative Example 1 -0.18％ 1.02％ 1.80％ Comparative Example 2 -0.16％ 1.30％ 2.14％ Comparative Example 3 -0.30％ 0.67％ 1.30％ Comparative Example 4 0.60％ 2.30％ 3.40％ Comparative Example 5 0.55％ 1.90％ 3.00％ Comparative Example 6 0.33％ 1.60％ 2.67％ Comparative Example 7 0.75％ 3.64％ 4.52％ Comparative Example 8 0.88％ 3.93％ 4.75％ Blank sample 1.04％ 4.36％ 5.31％

[0114] As Figures 3-4 shown in Tables 7-8, the efficacy test results of the test samples are the average values of the test results of 10 subjects in each group. After using the samples for 56 days, the skin glossiness of the subjects was tested (the larger the measured value, the better the skin glossiness). The skin glossiness of the subjects without using the sample decreased by 5.80%, while the skin glossiness of the subjects using the sample of Example 1 increased by 2.35%. This shows that the prepared whitening and brightening face cream can effectively improve the skin glossiness.

[0115] Table 7 Detection results of skin glossiness after 56 days

[0116] Time Before use After 14 days of use After 28 days of use After 56 days of use Example 1 10.21 10.25 10.32 10.45 Example 2 10.23 10.29 10.38 10.52 Example 3 10.25 10.32 10.43 10.58 Comparative Example 1 10.23 10.25 10.30 10.40 Comparative Example 2 10.25 10.26 10.30 10.39 Comparative Example 3 10.24 10.27 10.33 10.44 Comparative Example 4 10.23 10.18 10.20 10.25 Comparative Example 5 10.22 10.18 10.20 10.26 Comparative Example 6 10.23 10.20 10.24 10.28 Comparative Example 7 10.20 10.05 10.00 10.01 Comparative Example 8 10.19 10.01 9.91 9.86 Blank sample 10.18 9.92 9.69 9.59

[0117] Table 8 Change rate of skin gloss

[0118] Time After 14 days of use After 28 days of use After 56 days of use Example 1 0.39％ 1.08％ 2.35％ Example 2 0.58％ 1.47％ 2.83％ Example 3 0.70％ 1.76％ 3.22％ Comparative Example 1 0.19％ 0.68％ 1.66％ Comparative Example 2 0.10％ 0.49％ 1.36％ Comparative Example 3 0.29％ 0.88％ 1.95％ Comparative Example 4 -0.49％ -0.29％ 0.19％ Comparative Example 5 -0.39％ -0.19％ 0.39％ Comparative Example 6 -0.29％ 0.19％ 0.49％ Comparative Example 7 -1.47％ -1.96％ -1.86％ Comparative Example 8 -1.76％ -2.75％ -3.24％ Blank sample -2.55％ -4.81％ -5.80％

[0119] 3.2 Soothing effect test

[0120] Visia red area ratio test

[0121] Test instrument: facial image analyzer Visia

[0122] Test principle: Visia skin detector is an instrument capable of quantitatively analyzing the pathological characteristics of skin.

[0123] An ultra-high-definition camera is used to take pictures of the damaged area, and then process and read out the red area value.

[0124] The test results are shown in Table 11, which are the average values of the test results of 10 subjects in each group:

[0125] Table 11 Red area

[0126] Sample D0 D28 Red zone index change rate % Example 1 37.37 31.88 -14.69 Example 2 38.64 30.74 -20.44 Example 3 39.45 30.23 -23.37 Comparative Example 1 36.94 32.14 -12.99 Comparative Example 2 35.65 33.08 -7.20 Comparative Example 3 36.76 32.47 -11.67 Comparative Example 4 36.47 32.87 -9.87 Comparative Example 5 35.33 33.43 -5.38 Comparative Example 6 34.73 33.57 -3.34 Comparative Example 7 35.89 32.97 -8.14 Comparative Example 8 34.27 33.46 -2.36

[0127] Result explanation: After the subjects continuously used the product for 28 days, the Visia red area ratio of the skin of the test area of Examples 1-3 was significantly reduced compared with Comparative Examples 1-8. This indicates that the product can effectively soothe the skin of barrier-damaged skin and has a soothing effect.

[0128] The cream with whitening and soothing effects of the present application has a relatively significant whitening and skin lightening effect through the synergistic effect of the components, and the effect is more obvious than that of single whitening component or simultaneous use of two or three components. This is because the hydrolyzed corn protein, bis-diethoxydiglycol cyclohexane 1,4-dicarboxylic acid ester, long heart kappa seaweed extract and aminoethyl phosphinic acid are simultaneously compounded, and the four components synergistically inhibit tyrosinase activity, inhibit the oxidation reaction of the melanin generation process, weaken the stimulation of ultraviolet rays on melanocytes, reduce the generation of melanin, and inhibit the formation of melanin and spots from multiple aspects, prevent pigmentation, whiten, and brighten the skin. In addition, the formation of keratinization envelope is increased, thereby better protecting the morphology of keratinocytes. The keratinization envelope is more full, the arrangement is more compact, and the barrier function is better.

[0129] The foregoing description of the embodiments has been presented for the purpose of illustration and description. It is not intended to be exhaustive or to limit the application to the precise form disclosed. Modifications and variations are possible in light of the above teachings or can be acquired from practice of the application. As well, the description is presented in the context of the preferred embodiments as a number of alternatives. It is not intended to limit the application to the precise form described.

Claims

1. A composition having whitening, skin lightening, soothing efficacy, characterized in that, hydrolyzed corn protein, bis-diethoxydiglycol cyclohexane 1,4-dicarboxylic acid ester, longifolia kappa extract and aminoethyl phosphinic acid.

2. The composition with whitening and skin lightening and soothing efficacy according to claim 1, characterized in that, The weight ratio of the hydrolyzed corn protein, bis-diethoxydiglycol cyclohexane 1,4-dicarboxylic acid ester, longifolia kappa extract and aminoethyl phosphinic acid is (0.1-5):(0.5-2):(0.3-1.5):(0.5-1.5).

3. The composition with whitening and skin lightening and soothing efficacy according to claim 1, characterized in that, The weight ratio of the hydrolyzed corn protein, bis-diethoxydiglycol cyclohexane 1,4-dicarboxylic acid ester, longifolia kappa extract and aminoethyl phosphinic acid is (0.5-3.0):(1-2):(0.5-1):(0.5-1.2).

4. A skin product having a skin whitening and lightening effect and a soothing effect, characterized by, The skin care product contains the composition with whitening, skin lightening and soothing effect according to any one of claims 1-3, and the weight percentage of the composition with whitening, skin lightening and soothing effect in the skin care product is 0.4-9.5%.

5. The skin product with whitening and soothing effect according to claim 4, wherein the skin product is a skin care product. The skin care product further comprises a cosmetically acceptable carrier; The cosmetically acceptable carrier is selected from one or more of a solvent, a thickening agent, a skin conditioning agent, a humectant, an emulsifier, a esterifying agent, a pH adjuster, a fragrance or a preservative.

6. The skin product with whitening and soothing effect according to claim 5, wherein the skin product is a skin care product. The skin care product is in the form of solvent dispersion or suspension, or emulsified particles, or polymer encapsulation.

7. The skin product with skin whitening, brightening and soothing effects according to claim 4, characterized in that: The skin care product with whitening, skin lightening and soothing effect is a cream with whitening, skin lightening and soothing effect, and the total weight of the cream ingredients is 100%, and the cream ingredients comprise the following components in the following weight percentages: 0.4-9.5% of the composition with whitening, skin lightening and soothing effect, 15-25% of an emollient, 4-6% of an emulsifier, 0.01-1% of a filler, 0.5-2% of a thickening agent, 0.8-1.5% of a preservative, 0.02-0.2% of a fragrance, 0.1-10% of a skin conditioning agent, 0.1-10% of a humectant, and deionized water in the rest.

8. The skin care product with whitening, skin lightening and soothing effect according to claim 7, wherein The emollient is selected from one or more of behenyl alcohol, cetyl alcohol, caprylic / capric triglyceride, squalane, avocado oil, shea butter, jojoba esters, olive oil, dimethicone, dimethiconol, isohexadecane, phytosteryl, cocoyl octanoate / caprylate or isononyl isononanoate; and / or, The emulsifier is selected from one or more of polyglyceryl-3 methylglucose distearate, polyglyceryl-6 distearate, polyglyceryl-3 beeswaxate, cetyl phosphate potassium, methyl glucose sesquistearate, PEG-20 methyl glucose sesquistearate, steareth-21, cetyl stearyl alcohol, cetyl stearyl glucoside, glyceryl stearate or PEG-100 stearate; and / or, The filler is selected from one or more of boron nitride, synthetic fluorphlogopite, diatomaceous earth, kaolin, cellulose acetate or starch octyl hydroxypropyl distarate; and / or, The thickening agent is selected from one or more of carbomer, xanthan gum, acrylates / C10-30 alkyl acrylate crosspolymer, gum arabic, polymer EMT-10, sodium acrylates / acryloyldimethyltaurate, acrylates / C10-30 alkyl acrylate crosspolymer copolymer, hydroxyethyl cellulose, agarose or hectorite; and / or, The preservative is selected from one or more of phenoxyethanol, ethylhexylglycerin, farnesol, sodium benzoate or hexylene glycol; and / or, The skin conditioning agent is allantoin; and / or, The humectant is one or more of 1,2-pentanediol or sodium hyaluronate.

9. The method of preparing a skin product having whitening, skin lightening, soothing effect according to claim 4, characterized in that, The method comprises the step of mixing the composition having whitening, skin lightening and soothing effects according to any one of claims 1-3 and a cosmetically acceptable carrier to obtain the skin product having whitening, skin lightening and soothing effects.

10. The method of claim 9, wherein the skin product having whitening and soothing effects is prepared by adding the composition of claim 1 to a skin product base. The skin product having whitening, skin lightening and soothing effects is a cream having whitening, skin lightening and soothing effects, and the preparation method of the cream having whitening, skin lightening and soothing effects comprises the following steps: ​ 1) wetting and dispersing the thickening agent completely in deionized water to obtain a mixture, and then adding the humectant and stirring uniformly for use; 2) adding the emollient, the bulking agent and the emulsifier to the mixture in step 1) and heating to 80-85°C, and then homogenizing at 2000-3500 r / min for 3-5 minutes to make the mixture emulsify completely; 3) cooling to 43-45°C, and then adding the preservative, the skin conditioning agent, the composition having whitening, skin lightening and soothing effects and the fragrance to the mixture in step 2) to obtain the cream having whitening, skin lightening and soothing effects.

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