Sample analyzer and cleaning method thereof

Abstract

The invention discloses a sample analyzer and a cleaning method thereof.A reaction assembly of the sample analyzer is connected with a first power assembly through a pipeline, a first control end of a detection assembly is connected to the pipeline between the reaction assembly and the first power assembly, and a second power assembly is connected to the pipeline between the reaction assembly and the detection assembly through a pipeline; the first power assembly is used for driving the cleaning liquid in the reaction assembly to enter a pipeline between the reaction assembly and the detection assembly for cleaning, and the first power assembly is further used for driving the cleaning liquid between the reaction assembly and the detection assembly, so that the cleaning liquid enters the first power assembly to clean the first power assembly. By means of the mode, the sample analyzer can clean the first power assembly through the cleaning liquid of the pipeline between the reaction assembly and the detection assembly so as to clean impurities of the pipeline between the reaction assembly and the detection assembly and the first power assembly, the utilization rate of the cleaning liquid is increased, and then the cleaning effect of the sample analyzer is improved.

Description

Technical Field

[0001] This application relates to the field of medical device technology, and in particular to sample analyzers and their cleaning methods. Background Technology

[0002] A sample analyzer typically includes a reaction unit and a detection unit connected by tubing. The reaction unit stores the test sample suitable for counting tests, and the test sample is delivered to the detection unit through tubing. The detection unit performs counting tests on the flowing test sample and obtains the test results.

[0003] After a sample analyzer has tested a certain amount of sample, impurities such as cell debris and proteins will adsorb onto the reaction components, detection components, and corresponding tubing. The presence of these impurities contaminates the sample and affects the performance of certain components within the analyzer. Existing sample analyzers typically use enhanced cleaning solutions for cleaning; however, these solutions usually only clean the reaction and detection components, neglecting to clean the tubing and related components, resulting in ineffective cleaning. Summary of the Invention

[0004] To address the technical problem of poor cleaning performance of sample analyzers in the prior art, this application provides a sample analyzer and its cleaning method.

[0005] To address the aforementioned problems, this application provides a first technical solution: a sample analyzer comprising a reaction component, a detection component, a first power component, and a second power component. The reaction component stores the sample to be tested or a cleaning solution. The reaction component is connected to the first power component via a conduit. A first control terminal of the detection component is connected to the conduit between the reaction component and the first power component. The second power component is connected to the conduit between the reaction component and the detection component via a conduit. The second power component drives the sample to be tested in the reaction component into the detection component, and the detection component performs a counting test on the sample. The first power component drives the cleaning solution in the reaction component into the conduit between the reaction component and the detection component for conduit cleaning. The first power component also drives the cleaning solution in the conduit between the reaction component and the detection component to enter the first power component and clean it.

[0006] Optionally, the sample analyzer further includes a first control valve, the first control end of which is connected to the first control end of the reaction assembly via a pipeline, and the second control end of which is connected to the first control end of the detection assembly via a pipeline. The reaction assembly is used to store cleaning fluid, and the first power assembly is used to drive the cleaning fluid in the reaction assembly when the first control valve is turned on, so that the first cleaning fluid enters the pipeline between the reaction assembly and the detection assembly and cleans the pipeline. The first power assembly is also used to continue to drive the first cleaning fluid in the pipeline after the pipeline between the reaction assembly and the detection assembly is cleaned, so that the first cleaning fluid enters the first power assembly through the pipeline and cleans the first power assembly.

[0007] Optionally, the first power unit is used to continue driving the cleaning fluid of the reaction unit when the first control valve is turned on, so that the second cleaning fluid enters the pipeline between the reaction unit and the detection unit, and the second power unit is used to drive the second cleaning fluid in the pipeline to the detection unit to clean the detection unit.

[0008] Optionally, the first power assembly includes a pressure component, a second control valve, and a third control valve. The sample analyzer also includes a waste liquid assembly. The first control end of the second control valve is connected to a positive pressure source via a pipeline, the second control end of the second control valve is connected to a negative pressure source via a pipeline, the third control end of the second control valve is connected to the first control end of the pressure component via a pipeline, the second control end of the pressure component is connected to the first control end of the third control valve via a pipeline, the second control end of the third control valve is connected to a detection assembly via a pipeline, and the third control end of the third control valve is connected to the waste liquid assembly via a pipeline.

[0009] Optionally, the pipeline between the reaction component and the detection component stores a first cleaning fluid, a third control valve is used to control the connection of the pipeline between the pressure component and the detection component, and a second control valve is used to control the pressure component to be connected to the negative pressure source and the positive pressure source respectively according to a preset timing sequence, so that the first cleaning fluid moves back and forth between the pipeline between the reaction component and the detection component.

[0010] Optionally, the second power assembly includes a syringe and a fourth control valve, and the sample analyzer also includes a reagent assembly storing diluent. The first control end of the fourth control valve is connected to the reagent assembly via a tubing, and the second control end of the fourth control valve is connected to the first control end of the syringe via a tubing. The second control end of the syringe is connected to the second control end of the first control valve and the first control end of the detection assembly via tubing.

[0011] Optionally, the sample analyzer also includes a positive pressure source connected to the reagent assembly, with the first control valve and the fourth control valve in operation. The positive pressure source is used to drive the diluent in the reagent assembly to the reaction assembly through the pipeline and the first control valve, so as to clean the first control valve with the diluent.

[0012] Alternatively, the syringe is used to draw diluent from the reagent assembly and drive the diluent through tubing and the first control valve to the reaction assembly to clean the first control valve with the diluent.

[0013] Optionally, the fourth control valve is turned on, and the first power assembly is used to draw the diluent from the reagent assembly into the first power assembly through the pipeline, so as to clean the first power assembly with the diluent;

[0014] Alternatively, the syringe is used to draw up the diluent from the reagent assembly and drive the diluent into the tubing between the syringe and the first power assembly, which in turn draws up the diluent from the tubing to clean the first power assembly.

[0015] Optionally, the sample analyzer also includes a waste liquid assembly and a fifth control valve. The first control end of the fifth control valve is connected to the second control end of the detection assembly via a pipeline, and the second control end of the fifth control valve is connected to the waste liquid assembly via a pipeline. When the fifth control valve is turned on, the second power assembly is used to drive the sample to be tested in the reaction assembly into the detection assembly, so that the detection assembly can test the sample to be tested.

[0016] To address the aforementioned problems, this application provides a second technical solution: a cleaning method for a sample analyzer, applicable to the sample analyzer described above. The cleaning method includes: adding cleaning fluid to a reaction assembly to store a specific amount of cleaning fluid in the reaction assembly; drawing the cleaning fluid from the reaction assembly into a pipeline between the reaction assembly and the detection assembly via a first power assembly to clean the pipeline between the reaction assembly and the detection assembly; and continuing to draw the cleaning fluid from the pipeline between the reaction assembly and the detection assembly into the first power assembly to clean the first power assembly.

[0017] Unlike existing technologies, the sample analyzer of this application has a reaction component connected to a first power component via a pipeline. The first control terminal of the detection component is connected to the pipeline between the reaction component and the first power component. A second power component is connected to the pipeline between the reaction component and the detection component via a pipeline. The first power component drives the cleaning fluid in the reaction component to enter the pipeline between the reaction component and the detection component for pipeline cleaning. The first power component also drives the cleaning fluid in the pipeline between the reaction component and the detection component, allowing the cleaning fluid to enter and clean the first power component. Through this method, the sample analyzer of this application can utilize the cleaning fluid in the pipeline between the reaction component and the detection component to clean the first power component, thereby cleaning impurities in the pipeline between the reaction component and the detection component, as well as in the first power component, improving the utilization rate of the cleaning fluid and thus enhancing the cleaning effect of the sample analyzer. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. Wherein:

[0019] Figure 1 This is a schematic diagram of the structure of an embodiment of the sample analyzer provided in this application;

[0020] Figure 2 This is a flowchart illustrating the first embodiment of the cleaning method for the sample analyzer provided in this application;

[0021] Figure 3 This is a flowchart illustrating the second embodiment of the cleaning method for the sample analyzer provided in this application. Detailed Implementation

[0022] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.

[0023] It should be noted that if the embodiments of this application involve directional indicators (such as up, down, left, right, front, back, etc.), the directional indicators are only used to explain the relative positional relationship and movement of the components in a certain specific posture (as shown in the figure). If the specific posture changes, the directional indicators will also change accordingly.

[0024] Furthermore, if the embodiments of this application involve descriptions such as "first" or "second," these descriptions are for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, features defined with "first" or "second" may explicitly or implicitly include at least one of those features. Additionally, the technical solutions of various embodiments can be combined with each other, but this must be based on the ability of those skilled in the art to implement them. If the combination of technical solutions is contradictory or impossible to implement, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection claimed in this application.

[0025] Please see Figure 1 , Figure 1 This is a schematic diagram of the structure of an embodiment of the sample analyzer provided in this application. Figure 1As shown, the sample analyzer in this embodiment includes a reaction component 10, a detection component 20, a first power component 30, and a second power component 40.

[0026] The reaction assembly 10 is used to store the sample to be tested. The sample analyzer can receive sample tubes containing samples. The reaction assembly 10 receives the sample from the sample tube and the detection reagents required for the test. The sample and detection reagents react completely in the reaction assembly 10, so that the reaction assembly 10 stores the sample to be tested. At this time, the sample to be tested is a sample solution suitable for a specific detection item of the sample analyzer. The reaction assembly 10 is connected to the first power assembly 30 via tubing. The first control terminal of the detection assembly 20 is connected to the tubing between the reaction assembly 10 and the first power assembly 30, that is, the first control terminal of the detection assembly 20 is connected to both the reaction assembly 10 and the first power assembly 30. The second power assembly 40 is connected to the tubing between the reaction assembly 10 and the detection assembly 20, that is, the second power assembly 40 is connected to the first control terminal of both the reaction assembly 10 and the detection assembly 20 via tubing. The second power assembly 40 is used to drive the sample to be tested in the reaction assembly 10, so that the sample to be tested enters the detection assembly 20 through the tubing between the second power assembly 40 and the detection assembly 20. The detection assembly 20 is used to perform counting tests on the sample to be tested.

[0027] In an optional embodiment, the detection component 20 may include a flow chamber and an optical detection mechanism. The sample to be tested enters the flow chamber of the detection component 20 through a conduit between the second power component 40 and the detection component 20. The optical detection mechanism is used to perform optical counting of the sample to be tested passing through the flow chamber. Exemplarily, the optical detection mechanism may include a light receiver and a light generator. The light generator emits a laser beam towards the sample to be tested in the flow chamber, causing the cell particles of the sample to scatter light under laser irradiation. The light receiver receives the scattered light information from the cell particles of the sample to obtain the detection result of the sample. In other embodiments, the detection component 20 may also be used to perform other detection items such as impedance detection, which are not specifically limited here.

[0028] The second power unit 40 can be connected to the pipeline between the reaction component 10 and the detection component 20 via a pipeline, that is, the second power unit 40 is connected to the first control terminals of the reaction component 10 and the detection component 20 respectively via a pipeline. In a possible embodiment, both the first power unit 30 and the second power unit 40 can drive the liquid by changing the air pressure or pressure difference at the position of the pipeline or the corresponding connecting component, without specific limitations.

[0029] After the detection component 20 completes the testing of the sample, the reaction component 10, the pipeline between the reaction component 10 and the detection component 20, the detection component 20, and related control devices on the pipeline will adsorb some cell debris, proteins, and other impurities. This may lead to sample contamination, impurity blockage, or other accidents during the testing of the next sample. Therefore, the sample analyzer in this embodiment needs to clean the reaction component 10 with a dedicated cleaning solution, and the first power component 30 draws the cleaning solution from the reaction component 10 into the pipeline between the reaction component 10 and the detection component 20 to clean the pipeline, so that the pipeline between the reaction component 10 and the detection component 20 is filled with cleaning solution. The first power component 30 is also used to draw in the cleaning solution from the pipeline between the reaction component 10 and the detection component 20, so that the cleaning solution enters the first power component 30 through the pipeline and cleans the first power component 30.

[0030] The first control terminal of the detection component 20 of the sample analyzer of this application is connected to the reaction component 10 and the second power component 40 via pipelines. The first control terminal of the detection component 20 is also connected to the first power component 30 via a pipeline. After the pipeline between the reaction component 10 and the detection component 20 has been cleaned and contains cleaning fluid, the first power component 30 is used to draw in the cleaning fluid from the pipeline between the reaction component 10 and the detection component 20, so that the cleaning fluid enters the first power component 30 and cleans it. Through this method, the sample analyzer of this application can clean the first power component 30 using the cleaning fluid from the pipeline between the reaction component 10 and the detection component 20 after the pipeline between the reaction component 10 and the detection component 20 has been cleaned. This cleans impurities in the pipeline between the reaction component 10 and the detection component 20 and the first power component 30, reducing the adverse effects of impurities in the pipeline and the first power component 30, improving the utilization rate of the cleaning fluid, and thus improving the cleaning effect of the sample analyzer.

[0031] In one embodiment, the sample analyzer further includes a first control valve 53. The first control terminal of the first control valve 53 is connected to the first control terminal of the reaction assembly 10 via a pipeline, and the second control terminal of the first control valve 53 is connected to the first control terminal of the detection assembly 20 via a pipeline. The first control valve 53 controls the liquid flow rate in the pipeline between the reaction assembly 10 and the detection assembly 20. When the first control valve 53 is in a cut-off state, it cuts off the flow rate in the pipeline between the reaction assembly 10 and the detection assembly 20. When the first control valve 53 is in a conducting state, it opens the flow rate in the pipeline between the reaction assembly 10 and the detection assembly 20, allowing the sample to be tested or the cleaning solution of the reaction assembly 10 to enter the pipeline through the first control valve 53. The first control valve 53 includes, but is not limited to, a two-way valve. A second power assembly 40 can be connected to the pipeline between the first control valve 53 and the detection assembly 20 via a pipeline, that is, the second power assembly 40 is connected to the second control terminal of the first control valve 53 and the first control terminal of the detection assembly 20 via pipelines.

[0032] The reaction assembly 10 stores cleaning fluid. The first power assembly 30 drives the cleaning fluid in the reaction assembly 10 when the first control valve 53 is turned on, so that the cleaning fluid enters the pipeline between the reaction assembly 10 and the detection assembly 20 to clean the pipeline. The first power assembly 30 also continues to drive the first cleaning fluid in the pipeline after cleaning, so that all the first cleaning fluid enters the first power assembly 30 through the pipeline and cleans the first power assembly 30. In a possible embodiment, the first power assembly 30 changes the pressure in the pipeline between the reaction assembly 10 and the detection assembly 20, so that the reaction assembly 10 and the liquid between the reaction assembly 10 and the detection assembly 20 can be driven and enter a designated position under the action of a pressure difference.

[0033] Understandably, the first cleaning solution in the pipeline between the reaction component 10 and the detection component 20 is the cleaning solution used for the initial cleaning of the pipeline. The first cleaning solution may contain impurities such as cell debris and proteins. In this embodiment, the first power component 30 draws in all the first cleaning solution in the pipeline between the reaction component 10 and the detection component 20, so that the first power component 30 is cleaned by the first cleaning solution after the pipeline is cleaned, thereby improving the utilization rate of the cleaning solution. Furthermore, it reduces the possibility of impurities in the first cleaning solution entering other components through the pipeline, thereby reducing the contamination of other components by impurities and improving the cleaning effect of the sample analyzer.

[0034] Optionally, during or after the first power assembly 30 has completely drawn in the first cleaning fluid in the pipeline between the reaction assembly 10 and the detection assembly 20, the first power assembly 30 continues to drive the cleaning fluid in the reaction assembly 10 so that the second cleaning fluid enters the pipeline between the reaction assembly 10 and the detection assembly 20 to replace the first cleaning fluid. Then, the second power assembly 40 drives the second cleaning fluid in the pipeline to the detection assembly 20 to clean the detection assembly 20.

[0035] Specifically, during or after the first cleaning fluid in the pipeline between the reaction component 10 and the detection component 20 is completely drawn in by the first power component 30, the first power component 30 continues to drive the cleaning fluid in the reaction component 10, so that the second cleaning fluid enters the pipeline between the reaction component 10 and the detection component 20 to replace the first cleaning fluid drawn in by the first power component 30. Then, the second power component 40 drives the second cleaning fluid stored in the pipeline between the reaction component 10 and the detection component 20 to the detection component 20, so as to clean the detection component 20 with the second cleaning fluid. The second power component 40 is connected to the detection component 20 through a pipeline, and the second power component 40 drives the liquid in the pipeline between the reaction component 10 and the detection component 20, so that the sample to be tested or the cleaning fluid in the pipeline between the reaction component 10 and the detection component 20 enters the detection component 20.

[0036] Understandably, the second cleaning solution is the cleaning solution stored after the initial cleaning of the pipeline between the reaction component 10 and the detection component 20. The impurity content in the second cleaning solution is less than that in the first cleaning solution. In this embodiment, the second cleaning solution in the pipeline is driven to the detection component 20 by the second power component 40 to clean the detection component 20, preventing impurities in the first cleaning solution from entering the detection component 20 through the pipeline, reducing contamination of the detection component 20 by impurities, and further improving the cleaning effect of the sample analyzer.

[0037] Optionally, the first power assembly 30 includes a pressure component 31, a second control valve 32, and a third control valve 33. The sample analyzer also includes a waste liquid assembly 51. The first control end of the second control valve 32 is connected to a positive pressure source via a pipeline, the second control end of the second control valve 32 is connected to a negative pressure source via a pipeline, the third control end of the second control valve 32 is connected to the first control end of the pressure component 31 via a pipeline, the second control end of the pressure component 31 is connected to the first control end of the third control valve 33 via a pipeline, the second control end of the third control valve 33 is connected to the detection assembly 20 via a pipeline, and the third control end of the third control valve 33 is connected to the waste liquid assembly 51 via a pipeline.

[0038] Specifically, pressure component 31 includes, but is not limited to, devices such as pressure pumps and metering pumps, while the second control valve 32 and the third control valve 33 include, but are not limited to, three-way valves. The second control valve 32 controls the connection between the pipeline containing pressure component 31 and a positive or negative pressure source, and the third control valve 33 controls the connection between the pipeline containing pressure component 31 and the detection assembly 20 or the waste liquid assembly 51. The positive pressure source is defined as a pressure source with a pressure higher than atmospheric pressure, and the negative pressure source is defined as a pressure source with a pressure lower than atmospheric pressure; no specific limitations are imposed here.

[0039] For example, the second control valve 32 and the third control valve 33 may include a first state and a second state. In the first state, the third control valve 33 controls the connection of the pipeline between the pressure element 31 and the detection component 20, and the second control valve 32 controls the connection of the pipeline between the pressure element 31 and the negative pressure source. At this time, the pressure element 31 is under negative pressure, causing the liquid in the pipeline between the reaction component 10 and the detection component 20 to be drawn into the pressure element 31 under the action of pressure difference. In the second state, the third control valve 33 controls the connection of the pipeline between the pressure element 31 and the waste liquid assembly 51, and the second control valve 32 controls the connection of the pipeline between the pressure element 31 and the positive pressure source. At this time, the pressure element 31 is under positive pressure, and under the action of pressure difference, the liquid in the pressure element 31 and the pipeline between the pressure element 31 and the third control valve 33 is discharged into the waste liquid assembly 51, so that the waste liquid assembly 51 stores the waste liquid generated during the detection and cleaning process.

[0040] In this embodiment, the second control valve 32 changes the conduction state of the pressure component 31, so that the pressure component 31 can be in different pressure states. The pressure component 31 can be used to drive the cleaning fluid in the pipeline between the reaction component 10 and the detection component 20, so that the cleaning fluid enters the first power component 30 and cleans the first power component 30, thereby improving the cleaning effect of the sample analyzer.

[0041] Furthermore, the pressure component 31 can also be used to drive the cleaning fluid in the reaction component 10 into the pipeline between the reaction component 10 and the detection component 20, so that the pipeline between the reaction component 10 and the detection component 20 stores the first cleaning fluid. When cleaning the pipeline between the reaction component 10 and the detection component 20, the third control valve 33 is used to control the conduction of the pipeline between the pressure component 31 and the detection component 20, and the second control valve 32 is used to control the pressure component 31 to conduct to the negative pressure source and the positive pressure source respectively according to the preset timing sequence, so that the first cleaning fluid moves back and forth between the pipeline between the reaction component 10 and the detection component 20, further enhancing the cleaning effect of the pipeline between the reaction component 10 and the detection component 20.

[0042] Specifically, when the first power assembly 30 draws the first cleaning fluid from the reaction assembly 10 into the pipeline between the reaction assembly 10 and the detection assembly 20, the sample analyzer in this embodiment controls the second control valve 32 to open and close according to a preset timing sequence. The pressure component 31 is connected to the negative pressure source and the positive pressure source respectively under the preset timing sequence, so that the pressure component 31 is in a positive pressure, negative pressure, positive pressure, negative pressure and other states respectively, and the first cleaning fluid moves back and forth between the pipeline between the reaction assembly 10 and the detection assembly 20.

[0043] Understandably, when the second control valve 32 is open, the pipeline between the pressure component 31 and the negative pressure source is connected, and the first cleaning fluid in the pipeline between the reaction component 10 and the detection component 20 is drawn towards the pressure component 31 under the action of negative pressure; when the second control valve 32 is closed, the pipeline between the pressure component 31 and the positive pressure source is connected, and the first cleaning fluid in the pipeline between the reaction component 10 and the detection component 20 is discharged towards the reaction component 10 under the action of positive pressure, thereby causing the first cleaning fluid to move back and forth between the pipeline between the reaction component 10 and the detection component 20, so that the first cleaning fluid can repeatedly flush and clean the impurities adsorbed in the pipeline, improve the cleaning effect of the pipeline, and thus improve the cleaning effect of the sample analyzer.

[0044] Optionally, the second power assembly 40 includes a syringe 41 and a fourth control valve 42. The sample analyzer also includes a reagent assembly 60 storing diluent. The first control end of the fourth control valve 42 is connected to the reagent assembly 60 via a tubing. The second control end of the fourth control valve 42 is connected to the first control end of the syringe 41 via a tubing. The second control end of the syringe 41 is connected to the second control end of the first control valve 53 and the first control end of the detection assembly 40 via tubing, respectively.

[0045] Specifically, the syringe 41 is used to inject liquid or gas into the tubing between the reaction component 10 and the detection component 20 during movement, so that the liquid in the tubing between the reaction component 10 and the detection component 20 enters the detection component 20 under the drive of the gas or liquid, thereby realizing the detection of the sample to be tested or the cleaning of the detection component 20. In this embodiment, the sample analyzer uses the second power component 40 to push the cleaning fluid in the tubing between the reaction component 10 and the detection component 20 into the detection component 20, cleaning the tubing at the same time as cleaning the detection component 20, which can effectively improve the cleaning effect of the sample analyzer.

[0046] Furthermore, the reagent assembly 60 is connected to a positive pressure source (not shown), and the first control valve 53 and the fourth control valve 42 are turned on. The positive pressure source is used to drive the diluent in the reagent assembly 60 to the reaction assembly 10 through the pipeline and the first control valve 53, so as to clean the first control valve 53 with the diluent.

[0047] Specifically, after the detection component 20 is cleaned, a small amount of cleaning solution may still remain in the pipeline between the reaction component 10 and the detection component 20. Since the cleaning solution is an alkaline solution specifically designed for strong cleaning, its retention may corrode valves, pumps, and other components in the pipeline. To reduce the impact of the cleaning solution on the pipeline components, in this embodiment, when the third control valve 33 is used to control the pressure component 31 to be connected to the waste liquid component 51, and the pipeline containing the first control valve 53 and the fourth control valve 42 is connected, the sample analyzer controls the positive pressure source to drive the diluent in the reagent component 60 through the pipeline to the pipeline between the syringe 41 and the first control valve 53. This allows the diluent to enter the first control valve 53 through the pipeline, and then enter the reaction component 10 through the first control valve 53, thereby cleaning the first control valve 53, reducing the corrosion of the diaphragm of the first control valve 53 by the cleaning solution, improving the reliability of the first control valve 53, and thus increasing the service life of the sample analyzer.

[0048] Furthermore, the fourth control valve 42 is turned on, and the first power assembly 30 is used to draw in the diluent from the reagent assembly 60 to clean the first power assembly 30 with the diluent.

[0049] Specifically, when the fourth control valve 42 is open and the first control valve 53 is closed, the third control valve 33 is used to control the connection between the pressure component 31 and the detection component 20, and the second control valve 32 is used to control the connection between the pressure component 31 and the negative pressure source, so that the pressure component 31 can draw the diluent in the reagent component 60 under negative pressure, so as to clean the diaphragm of the pressure component 31 through the diluent, reduce the corrosion of the diaphragm of the pressure component 31 by the cleaning solution, improve the reliability of the pressure component 31, and thus improve the service life of the sample analyzer.

[0050] In other embodiments, the syringe 41 can be controlled to draw diluent from the reagent assembly 60 through a tubing and push the drawn diluent into the tubing between the syringe 41 and the first control valve 53, so that the diluent enters the first control valve 53 through the tubing, and then enters the reaction assembly 10 through the first control valve 53, thereby cleaning the first control valve 53, reducing the corrosion of the diaphragm of the first control valve 53 by the cleaning solution, improving the reliability of the first control valve 53, and thus improving the service life of the sample analyzer.

[0051] Furthermore, during the cleaning of the first power assembly 30, the syringe 41 can be controlled to first draw the diluent from the reagent assembly 60, and then the syringe 41 can be controlled to push the diluent into the tubing between the syringe 41 and the first power assembly 30. The first power assembly 30 then draws in the diluent from the tubing to clean itself. Specifically, when the fourth control valve 42 is open and the first control valve 53 is closed, the third control valve 33 controls the connection of the tubing between the pressure component 31 and the detection assembly 20, and the syringe 41 drives the drawn diluent into the tubing between the syringe 41 and the pressure component 31. The second control valve 32 controls the connection between the pressure component 31 and the negative pressure source, so that the pressure component 31 draws in the diluent from the tubing between the syringe 41 and the pressure component 31 under negative pressure, thereby cleaning the diaphragm of the pressure component 31, reducing corrosion of the diaphragm by the cleaning solution, improving the reliability of the pressure component 31, and thus extending the service life of the sample analyzer.

[0052] In one embodiment, the sample analyzer further includes a waste liquid assembly 51 and a fifth control valve 52. The first control terminal of the fifth control valve 52 is connected to the second control terminal of the detection assembly 20 via a pipeline, and the second control terminal of the fifth control valve 52 is connected to the waste liquid assembly 51 via a pipeline.

[0053] In this configuration, the fifth control valve 52 is activated, and the second power component 40 drives the sample to be tested in the reaction component 10 into the detection component 20, enabling the detection component 20 to test the sample. Specifically, the detection component 20 may include a flow chamber for optical counting as the sample flows through the detection area. After counting, the sample enters the waste liquid component 51 through a pipeline for storage, thus enabling the detection of the sample. When the detection component 20 is cleaned by the second cleaning fluid in the pipeline between the reaction component 10 and the detection component 20, the fifth control valve 52 is activated, and the second power component 40 pushes the second cleaning fluid in the pipeline into the detection component 20. The cleaned second cleaning fluid then enters the waste liquid component 51 through a pipeline, allowing the waste liquid component 51 to store the waste liquid generated during the detection and cleaning process. This ensures that the waste liquid is effectively contained in a designated location for subsequent processing, improving the analytical efficiency of the sample analyzer.

[0054] In one embodiment, the sample analyzer has a sixth control valve (not shown). The first control terminal of the sixth control valve is connected to the second control terminal of the reaction assembly 10 via a pipeline. The second control terminal of the sixth control valve is connected to the reagent assembly 60 via a pipeline. The reaction assembly 10 stores a cleaning solution of a first concentration. When the sixth control valve is open, the reagent assembly 60 delivers a diluent to the reaction assembly 10 via a pipeline, so that the reaction assembly 10 stores a cleaning solution of a second concentration. The first power assembly 30 is used to draw the cleaning solution of the second concentration from the reaction assembly 10 and perform cleaning. The second concentration is less than the first concentration. That is, the sample analyzer in this embodiment dilutes the cleaning solution of the first concentration stored in the reaction assembly 10 with a diluent to reduce the corrosiveness of the first concentration cleaning solution, reduce corrosion of the pipeline, and allow the first concentration cleaning solution stored in the reaction assembly 10 to be used for multiple cleanings, reducing the number of times the first concentration cleaning solution needs to be replenished and the usage cost, thus improving the user experience. In other embodiments, the sample analyzer can also directly add the first concentration cleaning solution to the reaction assembly 10 for cleaning, reducing the dilution process.

[0055] In one embodiment, the first control terminal of the detection component 20 is connected to the first control terminal of the reaction component 10 via a pipeline; the reagent component 60 can also be used to store the detection reagents required for detection, such as staining agents, hemolysins, etc. The reagent component 60 can be connected to the second control terminal of the reaction component 10 via other control valves. After the sampling component of the sample analyzer adds the sample in the sample tube to the reaction component 10, the detection reagent of the reagent component 60 is added to the reaction component 10 via a pipeline so that the sample and the detection reagent react completely in the reaction component 10 to obtain the sample to be tested.

[0056] Please see Figure 2 , Figure 2 This is a flowchart illustrating the first embodiment of the cleaning method for the sample analyzer provided in this application. Figure 2 As shown in the embodiments of this application, a cleaning method for a sample analyzer is also proposed. This cleaning method is applied to the sample analyzer of any of the above embodiments, and the cleaning method includes the following steps:

[0057] Step S11: Add the cleaning solution to the reaction assembly 10 so that the reaction assembly 10 stores a certain amount of cleaning solution.

[0058] Specifically, the cleaning solution can be directly drawn into the reaction component 10 through the sampling component, or the cleaning solution can be diluted with a diluent after being added. Users can choose according to the alkalinity, concentration, and required cleaning strength of the cleaning solution, etc., without making specific limitations here.

[0059] Step S12: The cleaning fluid in the reaction assembly 10 is drawn into the pipeline between the reaction assembly 10 and the detection assembly 20 through the first power assembly 30, so as to clean the pipeline between the reaction assembly 10 and the detection assembly 20.

[0060] The first power component 30 is used to draw the cleaning fluid from the reaction component 10 into the pipeline between the reaction component 10 and the detection component 20 through the pressure component 31, and to switch the positive pressure, negative pressure and other states of the pressure component 31 according to a preset sequence, so that the cleaning fluid moves back and forth in the pipeline between the reaction component 10 and the detection component 20 to enhance the cleaning effect.

[0061] Step S13: Continue to draw the cleaning fluid from the pipeline between the reaction component 10 and the detection component 20 into the first power component 30 to clean the first power component 30.

[0062] After the pipeline between the reaction component 10 and the detection component 20 is cleaned, the cleaning fluid in the pipeline between the reaction component 10 and the detection component 20 is continued to be drawn into the first power component 30 to achieve the reuse of the cleaning fluid. This reduces the adverse effects of impurities in the pipeline and the first power component 30 while improving the utilization rate of the cleaning fluid, thereby improving the cleaning effect of the sample analyzer.

[0063] Please see Figure 3 , Figure 3 This is a flowchart illustrating a second embodiment of the cleaning method for the sample analyzer provided in this application. Figure 3 As shown, in other embodiments, during or after step S13, the cleaning method may further include the following steps:

[0064] Step S14: The cleaning fluid in the reaction assembly 10 is continuously drawn into the pipeline between the reaction assembly 10 and the detection assembly 20 by the first power assembly 30, and the cleaning fluid in the pipeline between the reaction assembly 10 and the detection assembly 20 is pushed into the detection assembly 20 by the second power assembly 40 to clean the detection assembly 20.

[0065] Specifically, the cleaning fluid stored in the pipeline between the reaction component 10 and the detection component 20 during step S12 has been completely drawn into the first power component 30 during step S13. In this embodiment, the cleaning fluid is drawn back into the reaction component 10 when cleaning the detection component 20, so as to reduce the impurities contained in the cleaning fluid and prevent the impurities in the cleaning fluid from contaminating the detection component 20.

[0066] Step S15: The diluent in the reagent assembly 60 is pushed into the pipeline between the second power assembly 40 and the reaction assembly 10 and the first control valve 53 by a positive pressure source or the second power assembly 40, so as to clean the first control valve 53 by the diluent.

[0067] Specifically, a first control valve 53 is installed in the pipeline between the second power assembly 40 and the reaction assembly 10. The first control valve 53 is used to control the flow of the pipeline. After the detection assembly 20 is cleaned, in order to reduce the corrosion of valves, pumps and other devices in the pipeline by the cleaning solution, this embodiment needs to push the diluent in the reagent assembly 60 into the pipeline between the second power assembly 40 and the reaction assembly 10 and into the first control valve 53 through a positive pressure source or the second power assembly 40, so as to clean the cleaning solution on the first control valve 53 by the diluent, thereby reducing the corrosion of the first control valve 53 by the cleaning solution.

[0068] Step S16: The diluent in the reagent assembly 60 is drawn into the first power assembly 30 through the first power assembly 40, so as to clean the first power assembly 30 with the diluent.

[0069] Specifically, the diluent in the reagent assembly 60 can be directly drawn into the first power assembly 40 under negative pressure; alternatively, the diluent in the reagent assembly 60 can be first pushed into the pipeline between the second power assembly 40 and the first power assembly 30 by the second power assembly 40, and then drawn into the first power assembly 40 by the first power assembly 40. This allows the diluent to clean the cleaning solution on the first power assembly 30, reducing the corrosion of the first power assembly 30 by the cleaning solution.

[0070] Unlike existing technologies, the cleaning method in this embodiment can use a certain amount of cleaning solution to clean the reaction component 10, the detection component 20, the pipeline between the reaction component 10 and the detection component 20, and the valve devices on the pipeline, thereby maximizing the cleaning effect and efficiency, reducing the adverse effects of impurities on the instrument, and improving the accuracy of the sample analyzer's detection results.

[0071] The above description is merely an embodiment of this application and does not limit the patent scope of this application. Any equivalent structural or procedural transformations made using the content of this application's specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this application.

Claims

1. A sample analyzer, characterized in that, include: Reaction assembly, used to store the sample to be tested or the cleaning solution; The system includes a detection component, a first power component, and a second power component. The reaction component is connected to the first power component via a pipeline. The first control terminal of the detection component is connected to the pipeline between the reaction component and the first power component. The second power component is connected to the pipeline between the reaction component and the detection component via a pipeline. The second power component is used to drive the sample to be tested in the reaction component into the detection component. The detection component is used to perform a counting test on the sample to be tested. Wherein, the first power component is used to drive the cleaning fluid in the reaction component to enter the pipeline between the reaction component and the detection component for pipeline cleaning. The first power component is also used to drive the cleaning fluid in the pipeline between the reaction component and the detection component, so that the cleaning fluid enters the first power component and cleans the first power component.

2. The sample analyzer according to claim 1, characterized in that, The sample analyzer further includes a first control valve, the first control end of which is connected to the first control end of the reaction component via a pipeline, and the second control end of which is connected to the first control end of the detection component via a pipeline. The reaction assembly is used to store cleaning fluid. The first power assembly is used to drive the cleaning fluid in the reaction assembly when the first control valve is turned on, so that the first cleaning fluid enters the pipeline between the reaction assembly and the detection assembly and cleans the pipeline. The first power assembly is also used to continue to drive the first cleaning fluid in the pipeline after the pipeline between the reaction assembly and the detection assembly is cleaned, so that the first cleaning fluid enters the first power assembly through the pipeline and cleans the first power assembly.

3. The sample analyzer according to claim 2, characterized in that, The first power component is used to continue driving the cleaning fluid of the reaction component when the first control valve is turned on, so that the second cleaning fluid enters the pipeline between the reaction component and the detection component. The second power component is used to drive the second cleaning fluid in the pipeline to the detection component to clean the detection component.

4. The sample analyzer according to claim 2, characterized in that, The first power assembly includes a pressure component, a second control valve, and a third control valve. The sample analyzer also includes a waste liquid assembly. The first control terminal of the second control valve is connected to a positive pressure source via a pipeline, and the second control terminal of the second control valve is connected to a negative pressure source via a pipeline. The third control terminal of the second control valve is connected to the first control terminal of the pressure component via a pipeline, and the second control terminal of the pressure component is connected to the first control terminal of the third control valve via a pipeline. The second control terminal of the third control valve is connected to the detection assembly via a pipeline, and the third control terminal of the third control valve is connected to the waste liquid assembly via a pipeline.

5. The sample analyzer according to claim 4, characterized in that, The pipeline between the reaction component and the detection component stores the first cleaning fluid. The third control valve is used to control the connection of the pipeline between the pressure component and the detection component. The second control valve is used to control the pressure component to be connected to the negative pressure source and the positive pressure source respectively according to a preset timing sequence, so that the first cleaning fluid moves back and forth between the pipeline between the reaction component and the detection component.

6. The sample analyzer according to claim 2 or 3, characterized in that, The second power assembly includes a syringe and a fourth control valve. The sample analyzer also includes a reagent assembly storing diluent. The first control end of the fourth control valve is connected to the reagent assembly via a tubing. The second control end of the fourth control valve is connected to the first control end of the syringe via a tubing. The second control end of the syringe is connected to the second control end of the first control valve and the first control end of the detection assembly via tubing.

7. The sample analyzer according to claim 6, characterized in that, The sample analyzer also includes a positive pressure source connected to the reagent assembly. The first control valve and the fourth control valve are connected. The positive pressure source is used to drive the diluent in the reagent assembly to the reaction assembly through the pipeline and the first control valve, so as to clean the first control valve with the diluent. Alternatively, the syringe is used to draw the diluent from the reagent assembly and drive the diluent through tubing and the first control valve to the reaction assembly to clean the first control valve with the diluent.

8. The sample analyzer according to claim 6, characterized in that, When the fourth control valve is turned on, the first power assembly is used to draw the diluent from the reagent assembly into the first power assembly through a pipeline, so as to clean the first power assembly with the diluent. Alternatively, the syringe is used to draw the diluent from the reagent assembly and drive the diluent into a conduit between the syringe and the first power assembly, the first power assembly being used to draw in the diluent from the conduit to clean the first power assembly with the diluent.

9. The sample analyzer according to claim 1, characterized in that, The sample analyzer also includes a waste liquid assembly and a fifth control valve. The first control terminal of the fifth control valve is connected to the second control terminal of the detection assembly via a pipeline, and the second control terminal of the fifth control valve is connected to the waste liquid assembly via a pipeline. Specifically, the fifth control valve is turned on, and the second power component is used to drive the sample to be tested in the reaction component into the detection component, so that the detection component can test the sample to be tested.

10. A cleaning method for a sample analyzer, characterized in that, Applied to the sample analyzer as described in any one of claims 1-9, the cleaning method comprises: A cleaning solution is added to the reaction assembly so that the reaction assembly stores a certain amount of cleaning solution; The cleaning fluid in the reaction assembly is drawn into the pipeline between the reaction assembly and the detection assembly through the first power assembly, so as to clean the pipeline between the reaction assembly and the detection assembly. The cleaning fluid in the pipeline between the reaction component and the detection component is continued to be drawn into the first power component to clean the first power component.

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