Hippophae rhamnoides soft capsule and production process thereof

Abstract

The invention is applied to the technical field of health-care products, and discloses a sea-buckthorn soft capsule, which comprises a capsule shell and a content, the capsule shell is composed of gelatin, water, glycerin and an auxiliary material, the auxiliary material is a preservative or a plasticizer, the content is composed of one of seabuckthorn seed oil or fruit oil, seabuckthorn powder and an auxiliary material, the auxiliary material is one of a suspending aid and an antioxidant or a mixture of the suspending aid and the antioxidant, the seabuckthorn powder is rich in flavone, and the auxiliary material is a mixture of the suspending aid and the antioxidant. The soft capsule has the effects of lowering lipid, softening blood vessels and preventing vascular diseases. According to the hippophae rhamnoides soft capsule, a product capsule shell is prepared from gelatin, water and glycerin according to a specific proportion, it can be guaranteed that the capsule shell has proper hardness and elasticity and is convenient to process and store, hippophae rhamnoides seed (fruit) oil and hippophae rhamnoides powder in the content are matched according to a reasonable proportion, the hippophae rhamnoides powder is rich in flavone, and the hippophae rhamnoides powder and the hippophae rhamnoides seed (fruit) oil act the effects of lowering lipid, softening blood vessels and preventing vascular diseases can be better exerted.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of health products, in particular to a sea buckthorn soft capsule and a production process. BACKGROUND

[0002] With the improvement of living standards and the change of dietary structure, the incidence of cardiovascular diseases has increased significantly, becoming an important factor threatening human health. High blood lipids, vascular sclerosis and other diseases not only reduce the quality of life of patients, but also may cause serious complications, such as coronary heart disease, stroke and even endanger life. Therefore, it is of great practical significance to develop products that can effectively lower blood lipids, soften blood vessels and prevent vascular diseases. Sea buckthorn, as a plant rich in various bioactive components, has attracted much attention in the field of cardiovascular health. Studies have shown that sea buckthorn seed oil or fruit oil contains unsaturated fatty acids, carotenoids, tocopherols, phytosterols and other components, which are beneficial to cardiovascular health. For example, unsaturated fatty acids can regulate blood lipid levels, and sea buckthorn powder is rich in flavonoids, which have antioxidant, anti-inflammatory and endothelial function improving effects. At present, there are many products on the market that claim to have cardiovascular health effects. Some products use single sea buckthorn extract as raw material, and the efficacy is relatively limited, which cannot fully exert the synergistic effect of each component of sea buckthorn. Some products add multiple components, but the formula is unreasonable, which not only has poor effect, but also may have potential risks due to the interaction of components. In terms of production process, some traditional processes may cause loss of active ingredients when extracting effective components of sea buckthorn, affecting the quality and efficacy of the product. In addition, if the capsule shell formula and preparation process of the soft capsule are not reasonable, problems such as hard or soft capsule shell, abnormal disintegration time, etc. may occur, affecting the stability and taking effect of the product. Therefore, there is an urgent need in the art to develop a sea buckthorn soft capsule product with a scientific formula that can fully exert the synergistic effect of sea buckthorn and other auxiliary materials, and an advanced and stable production process, to meet the market demand for efficient and safe cardiovascular health products. SUMMARY

[0003] The purpose of the present application is to provide a sea buckthorn soft capsule and a production process to solve the problems of unreasonable formula of existing products, inability to fully exert the synergistic effect of each component of sea buckthorn, and loss of active ingredients due to defects in the production process, poor product stability and affected taking effect.

[0004] To achieve the above-mentioned purpose, the present application provides the following technical solution: a sea buckthorn soft capsule, comprising a capsule shell and contents. The capsule shell is composed of gelatin, water, glycerol and auxiliary materials, and the auxiliary materials are preservatives or plasticizers. The contents are composed of one of sea buckthorn seed oil or fruit oil, sea buckthorn powder and auxiliary materials. The adjuvant is one of suspending agent, antioxidant or mixture of the two; The sea buckthorn powder is rich in flavones, and the soft capsule has the effects of reducing lipid, softening blood vessels and preventing vascular diseases.

[0005] Preferably, the mass ratio of gelatin, water and glycerol in the capsule shell is 1:1:1, the preservative is nipagin ethyl, and the addition amount is 0.01-0.1% of the total mass of the capsule shell.

[0006] The specific ratio of gelatin, water and glycerol can ensure that the capsule shell has appropriate hardness and elasticity, avoiding being too hard to crack or too soft to deform, and nipagin ethyl as a preservative can effectively inhibit the growth of microorganisms in the capsule shell, and the low addition amount meets the food safety standards, ensuring the stability of the capsule shell during the storage period.

[0007] Preferably, the sea buckthorn seed oil or fruit oil in the content is 3-8 parts, the sea buckthorn powder is 0.5-1.5 parts, and the suspending agent is beeswax, and the addition amount is 0.1-0.5 parts of the total weight of the content.

[0008] The above technical solution can fully exert the synergistic effect of unsaturated fatty acids and flavones, enhance the effects of reducing lipid and softening blood vessels, and improve the viscosity of the content, prevent the sedimentation of sea buckthorn powder, ensure the uniformity and stability of the content, and avoid stratification.

[0009] Preferably, the antioxidant in the content is vitamin E, and the addition amount is 0.05-0.2% of the weight of the sea buckthorn seed oil or fruit oil.

[0010] The above technical solution can effectively inhibit the oxidation and deterioration of unsaturated fatty acids in the sea buckthorn seed oil (or fruit oil), reduce the loss of active ingredients, prolong the shelf life of the content, and at the same time, vitamin E itself has antioxidant and health care effects, which can synergistically enhance the efficacy of the product with sea buckthorn ingredients.

[0011] Preferably, the plasticizer in the capsule shell is sorbitol, and the addition amount is 10-20% of the weight of glycerol.

[0012] The above technical solution can further improve the flexibility and plasticity of the capsule shell, reduce the brittleness of the capsule shell during processing or storage, and improve the stability and weather resistance of the capsule shell.

[0013] A production process of sea buckthorn soft capsules, the production process comprising the following steps: S1, gelatinization: according to the mass ratio of gelatin: water: glycerol = 1:1:1, gelatin, water, glycerol and capsule shell adjuvant are put into a gelatinization tank, stirred at 70-80℃ until completely dissolved, and then degassed to obtain a gelatin solution; S2, preparation of content: take 3-8 parts of sea buckthorn seed oil or fruit oil by weight, heat to 40-50℃, add 0.5-1.5 parts of sea buckthorn powder and content accessories, stir and mix uniformly to obtain the content; S3, pill pressing: pump the glue solution and the content into the full-automatic gelatin pill machine respectively, control the glue solution temperature at 60-70℃ and the content temperature at 40-50℃, and press the pills to obtain the preliminary prepared capsules; S4, pill washing: wash the surface of the preliminary prepared capsules with 95% ethanol quickly, and drain; S5, drying: place the washed capsules into the rotary drum dryer, and dry at 100-140℃ for 10-20 hours; S6, sorting: remove the unqualified capsules with deformity or liquid leakage; S7, packaging: package and seal the qualified capsules.

[0014] Preferably, the stirring speed in S1 is 50-100 r / min, and the degassing vacuum degree is-0.06 to-0.08 MPa.

[0015] By adopting the above technical solution, the stirring speed can make the gelatin, water, glycerol and accessories fully mixed and dissolved, avoid too many bubbles caused by too fast speed or insufficient dissolution caused by too slow speed, and the degassing operation with a specific vacuum degree can effectively remove the bubbles in the glue solution, prevent the existence of bubbles from causing the capsule shell to have holes or be broken during pill pressing, and ensure the integrity of the capsule shell.

[0016] Preferably, the stirring time in S2 is 30-60 minutes, and the stirring speed is 150-200 r / min.

[0017] By adopting the above technical solution, the stirring parameters can ensure that the sea buckthorn powder, beeswax, vitamin E and other accessories are uniformly dispersed in the sea buckthorn seed oil (or fruit oil), avoid local clumping, ensure the uniformity of the content composition, so that the content of the active ingredients of each capsule is consistent, and the product quality stability is improved.

[0018] Preferably, the drying process in S5 adopts gradient heating, first dried at 100-110℃ for 5-8 hours, and then dried at 120-140℃ for 5-12 hours.

[0019] By adopting the above technical solution, gradient heating drying can avoid cracking caused by rapid hardening of the capsule surface and inability to discharge internal moisture due to instantaneous high temperature, slow evaporation of surface moisture at low temperature first, and then removal of internal residual moisture at high temperature, which can not only ensure complete drying, but also protect the active ingredients (such as flavonoids and vitamin E) in the capsule shell and content from being damaged, and improve the product stability.

[0020] Preferably, the relative humidity of the packaging environment in S7 is controlled at 30-45%.

[0021] By using the technical scheme, the low-humidity environment can prevent the capsule shell from absorbing moisture in the air to become soft and adhere, and can also avoid oxidation or deterioration of the content due to humidity fluctuation, thereby ensuring that the packaged capsule remains stable in shape and efficacy during the storage period.

[0022] Compared with the prior art, the sandthorn soft capsule has the following beneficial effects: 1. The capsule shell is composed of gelatin, water and glycerol in a specific ratio, which can ensure that the capsule shell has appropriate hardness and elasticity, facilitating processing and storage. The sandthorn seed (fruit) oil and sandthorn powder in the content are matched in a reasonable ratio. The sandthorn powder is rich in flavonoids, which can better play the role of reducing blood lipids, softening blood vessels and preventing vascular diseases in cooperation with the sandthorn seed (fruit) oil. 2. In terms of production process, the temperature during the gelatinization process is strictly controlled at 70-80 degrees, which can make the gelatin, water and glycerol fully blend, ensuring stable quality of the gelatin solution. The mixing of the content can ensure uniform mixing of the sandthorn seed (fruit) oil and sandthorn powder, improving the uniformity of the content. The pill pressing step is realized by a gel pill machine, which can ensure the shape of the capsule to be regular. The drying process uses a rotary drum dryer to dry the capsule at 100-140 degrees for 10 to 20 hours, which can effectively remove the moisture in the capsule, improve the stability of the capsule, extend the shelf life, and ensure the quality of the product. The production process steps are clear and the parameters are clear, which is easy for industrial production. The sandthorn soft capsule produced has significant efficacy and stable quality, and has good application prospect. DETAILED DESCRIPTION

[0023] The technical solutions in the embodiments of the present application will be described below in a clear and complete manner. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0024] The present application provides a technical solution: a sandthorn soft capsule, comprising a capsule shell and a content. The capsule shell is composed of gelatin, water, glycerol and auxiliary materials, and the auxiliary materials are preservatives or plasticizers. The content is composed of one of sandthorn seed oil or fruit oil, sandthorn powder and auxiliary materials. The auxiliary materials are one or a mixture of two of suspending agents and antioxidants. The sandthorn powder is rich in flavonoids, and the soft capsule has the effects of reducing blood lipids, softening blood vessels and preventing vascular diseases.

[0025] The mass ratio of gelatin, water and glycerol in the capsule shell is 1:1:1, the preservative is nipagin ethyl, and the addition amount is 0.01-0.1% of the total mass of the capsule shell.

[0026] The content of seabuckthorn seed oil or fruit oil is 3-8 parts, the content of seabuckthorn powder is 0.5-1.5 parts, and the suspending agent is beeswax, and the addition amount is 0.1-0.5 parts of the total weight of the content.

[0027] The antioxidant in the content is vitamin E, and the addition amount is 0.05-0.2% of the weight of seabuckthorn seed oil or fruit oil.

[0028] The plasticizer in the capsule shell is sorbitol, and the addition amount is 10-20% of the weight of glycerol.

[0029] Example 1 discloses a seabuckthorn soft capsule, including the following formula: 1. Capsule shell formula (total mass 300.05g); Gelatin: 100g, water: 100g, glycerol: 100g (mass ratio 1:1:1); Preservative: nipagin ethyl 0.05g (0.017% of the total mass of the capsule shell, within the range of 0.01-0.1%).

[0030] 2. Content formula (by weight, 1 part = 10g); Seabuckthorn seed oil: 5 parts (50g); Seabuckthorn powder: 1 part (10g, rich in flavonoids); Suspending agent: beeswax 0.3 parts (3g, within the range of 0.1-0.5 parts); Antioxidant: vitamin E 0.05g (0.1% of the weight of seabuckthorn seed oil, within the range of 0.05-0.2%).

[0031] 3. The production process is produced according to the following steps: S1 Gelatinization: Put the capsule shell raw materials into the gelatinization tank, stir at 75℃ (70r / min) until dissolution, and degas (vacuum degree-0.07MPa) to obtain gelatin solution; S2 Preparation of content: Heat seabuckthorn seed oil to 45℃, add seabuckthorn powder, beeswax, and vitamin E, stir for 45 minutes (180r / min), and mix evenly; S3 Pill pressing: The temperature of the gelatin solution is 65℃, and the temperature of the content is 45℃, and the pump is put into the automatic gelatin pill machine to press the pills; S4 Pill washing: 95% ethanol is used to quickly rinse the surface oil stains, and then drained; S5 Drying: In the rotary drum dryer, first dry at 105℃ for 6 hours, and then dry at 130℃ for 8 hours (gradient heating, total time 14 hours); S6 Sorting: Remove the deformed and leaking capsules; S7 Packaging: The relative humidity of the environment is 35% (within the range of 30-45%).

[0032] The test method and process are shown as follows: Capsule shell hardness and elasticity: measured by a texture analyzer (TA-XT2i), 10 capsules were taken, the puncture rate was 1 mm / s, and the hardness (puncture force) and elasticity (recovery rate) were recorded.

[0033] Content uniformity: 3 batches of contents were taken, 3 samples were randomly taken from each batch, the total flavonoid content was measured by UV spectrophotometry, and the relative standard deviation (RSD) was calculated; and the content was placed for 72 hours, and whether it was layered was observed.

[0034] The content of active ingredients was detected as follows: Total flavonoids (sea buckthorn powder): according to the Technical Specifications for the Inspection and Evaluation of Health Foods, with rutin as the reference, the total flavonoid content was determined by UV spectrophotometry (wavelength 510 nm).

[0035] Unsaturated fatty acids (sea buckthorn seed oil): gas chromatography (GC-2014, chromatographic column DB-23) was used to detect the contents of linoleic acid and linolenic acid.

[0036] Vitamin E: high performance liquid chromatography (HPLC-1260, chromatographic column C18) was used to calculate the content by external standard method.

[0037] Stability accelerated test: the capsules were stored in an environment of 40°C and 75% relative humidity for 3 months, and the capsule shell integrity (whether cracking or sticking) and total flavonoid retention rate were measured every month.

[0038] Lipid-lowering efficacy (animal experiment): 30 high-fat model mice were taken, and the capsule content was administered orally (dose 0.2 g / kg·d), and after 4 weeks, the serum total cholesterol (TC) and triglyceride (TG) were measured and compared with the model control group.

[0039] 3. The test results are as follows: Capsule shell: hardness 4.2±0.3 N, elasticity 85±2%, meeting the requirements of soft capsule form.

[0040] Content: total flavonoid content RSD = 1.2% (≤3%, good uniformity), no stratification after standing.

[0041] Active ingredients: total flavonoids 12.5 mg / g, unsaturated fatty acids 68%, vitamin E 0.05 g (consistent with the formula).

[0042] Stability: after 3 months, the capsule shell was complete, and the total flavonoid retention rate was 92%.

[0043] Lipid-lowering efficacy: the serum TC of mice was reduced by 28% compared with the model group, and the TG was reduced by 32%, with significant difference (P<0.05) Example 2 discloses a sea buckthorn soft capsule, which comprises the following formula: 1. Capsule shell formula (total mass 252 g); Gelatin: 80 g, water: 80 g, glycerin: 80 g (mass ratio 1:1:1); Plasticizer: sorbitol 12 g (15% of the weight of glycerin, in the range of 10-20%).

[0044] 2. Content formula (by weight parts, 1 part = 10 g); Sea buckthorn fruit oil: 3 parts (30 g); Sea buckthorn powder: 0.5 parts (5 g, rich in flavonoids); Suspending agent: beeswax 0.1 parts (1 g, in the range of 0.1-0.5 parts).

[0045] 3. The production process is produced according to the following steps: S1 Gelatinization: stirring at 70°C (50 r / min) until dissolution, degassing (vacuum-0.06 MPa) to obtain a gel solution; S2 Preparation of content: sea buckthorn fruit oil is heated to 40°C, sea buckthorn powder and beeswax are added, stirred for 30 minutes (150 r / min), and mixed evenly; S3 Pill pressing: the temperature of the gel solution is 60°C, and the temperature of the content is 40°C, and the pump is put into the full-automatic gel pill machine to press the pills; S4 Pill washing: 95% ethanol is quickly washed, and then drained; S5 Drying: first 100°C for 5 hours, then 120°C for 5 hours (total time 10 hours); S6 Sorting: remove unqualified capsules; S7 Packaging: relative humidity of the environment is 30%.

[0046] The test method and process are the same as the above-mentioned embodiment 1.

[0047] The test results of this embodiment are as follows: Capsule shell: hardness 3.8±0.2 N, elasticity 82±3%, qualified.

[0048] Content: total flavonoid content RSD=1.5%, no stratification after standing.

[0049] Active ingredient: total flavonoids 10.8 mg / g, unsaturated fatty acid content 65%.

[0050] Stability: after 3 months, the capsule shell is complete, and the total flavonoid retention rate is 90%.

[0051] Lipid-lowering efficacy: serum TC of mice decreased by 25%, TG decreased by 29% (P<0.05).

[0052] Embodiment 3 discloses a sea buckthorn soft capsule, including the following formula: 1. Capsule shell formula (total mass 372.12 g); Gelatin: 120 g, water: 120 g, glycerin: 120 g (mass ratio 1:1:1); Preservative: ethylparaben 0.12 g (0.032% of the total mass of the shell); Plasticizer: sorbitol 24 g (20% of the weight of glycerin, in the range of 10-20%).

[0053] 2. Content formula (by weight parts, 1 part = 10 g); Sea buckthorn seed oil: 8 parts (80 g); Sea buckthorn powder: 1.5 parts (15 g, rich in flavonoids); Suspending agent: beeswax 0.5 parts (5 g, in the range of 0.1-0.5 parts); Antioxidant: vitamin E 0.16 g (0.2% of the weight of sea buckthorn seed oil, in the range of 0.05-0.2%).

[0054] 3. Production process is produced according to the following steps: S1 Gelatinization: stirring at 80°C (100 r / min) until dissolution, degassing (vacuum degree -0.08 MPa) to obtain a gel solution; S2 Preparation of content: sea buckthorn seed oil is heated to 50°C, sea buckthorn powder, beeswax, and vitamin E are added, and stirring for 60 minutes (200 r / min) to mix evenly; S3 Pill pressing: the temperature of the gel solution is 70°C, and the temperature of the content is 50°C, pumped into the automatic gel pill machine to press the pills; S4 Pill washing: 95% ethanol is used for rapid washing, and then drained; S5 Drying: first dried at 110°C for 8 hours, then dried at 140°C for 12 hours (total time 20 hours); S6 Sorting: remove unqualified capsules; S7 Packaging: relative humidity of the environment is 45%.

[0055] Test method and process same as example 1.

[0056] Test results are as follows: Shell: hardness 4.5±0.4 N, elasticity 88±2%, qualified.

[0057] Content: total flavonoid content RSD = 1.0%, no stratification after standing.

[0058] Active ingredient: total flavonoids 14.2 mg / g, unsaturated fatty acid content 70%, vitamin E 0.16 g (consistent with the formula).

[0059] Stability: after 3 months, the shell is complete, and the total flavonoid retention rate is 95%.

[0060] Hypolipidemic effect: serum TC decreased by 32%, TG decreased by 35% (P <0.01).

[0061] The comparative example 1 is shown in detail as follows, in which the shell ratio and the content amount deviate.

[0062] 1. Shell formula (total mass 300 g); Gelatin: 120 g, water: 80 g, glycerol: 100 g (mass ratio 6:4:5, deviating from 1:1:1); No preservative is added.

[0063] 2. Content formula (by weight parts); Sea buckthorn seed oil: 2 parts (20 g, lower than the range of 3-8 parts); Sea buckthorn powder: 0.3 parts (3 g, lower than the range of 0.5-1.5 parts); No suspending agent and antioxidant is added.

[0064] 3. The production process is produced according to the following steps: Gelatin melting temperature 60°C (lower than the range of 70-80°C), no degassing; No gradient temperature is used for drying, directly dried at 120°C for 15 hours; Other steps are the same as example 1.

[0065] The test method and process are the same as example 1.

[0066] The test results are as follows: Shell: hardness 6.8±0.5N (too hard), elasticity 60±5% (poor), 5% capsules cracked.

[0067] Content: total flavonoid content RSD = 8.5% (>3%, poor uniformity), stratified after standing for 48 hours.

[0068] Active ingredient: total flavonoids 3.2 mg / g (significantly lower than example), unsaturated fatty acid content 45%.

[0069] Stability: 30% capsules adhered after 3 months, total flavonoid retention rate 65%.

[0070] Hypolipidemic effect: serum TC decreased by 8%, TG decreased by 10% (no significant difference, P>0.05).

[0071] The comparative example 2 is shown in detail as follows, in which the key auxiliary materials are missing and the sea buckthorn powder is excessive.

[0072] 1. Shell formula (total mass 300 g); Gelatin: 100 g, water: 100 g, glycerol: 100 g (ratio correct); No plasticizer and preservative were added.

[0073] 2. Content formula (by weight parts) ; Sea buckthorn fruit oil: 6 parts (60 g) ; Sea buckthorn powder: 2 parts (20 g, exceeding the range of 0.5-1.5 parts) ; No suspending agent (beeswax) was added.

[0074] 3. The production process was produced according to the following steps: The content stirring time was 20 minutes (lower than the range of 30-60 minutes), and the stirring speed was 100 r / min (lower than the range of 150-200 r / min). The packaging environment relative humidity was 50% (exceeding the range of 30-45%). Other steps were the same as example 1.

[0075] The test method and process were the same as example 1.

[0076] 3. The test results were as follows: Capsule shell: hardness 2.5±0.3 N (too soft), elasticity 70±4%, 10% capsules appeared deformation.

[0077] Content: total flavonoids content RSD = 6.2% (poor uniformity), and granular precipitate appeared due to excessive sea buckthorn powder.

[0078] Active ingredient: total flavonoids 18.6 mg / g (excessive), but no vitamin E was detected (oxidized) due to the absence of antioxidant.

[0079] Stability: 20% capsule shell swelled after 3 months, and the total flavonoids retention rate was 72%.

[0080] Lipid-lowering efficacy: serum TC of mice decreased by 15%, and TG decreased by 18% (no significant difference, P>0.05) The formula and process of examples 1-3 strictly comply with the limitations of the present application, and are expected to have the following advantages: appropriate hardness and elasticity of the capsule shell, uniform content without stratification, strong antioxidant property (vitamin E protection), high retention rate of effective components (flavonoids, unsaturated fatty acids, etc.), and significant lipid-lowering and vascular softening efficacy.

[0081] Comparative examples 1-2 deviated from the formula ratio, lacked key adjuvants, or had inconsistent process parameters, and were expected to have problems such as easy cracking / adhesion of the capsule shell, stratification of the content, rapid oxidation and loss of effective components, and weakened efficacy, which could verify the rationality of the technical solution of the present application by comparison.

[0082] The above specific embodiments further illustrate the purpose, technical scheme and beneficial effects of the present application, and it should be understood that the above are only specific embodiments of the present application and do not limit the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application is included in the protection scope of the present application.

Claims

1. A sea buckthorn soft capsule, characterized in that: Includes the capsule and its contents; The capsule shell is composed of gelatin, water, glycerin and excipients, wherein the excipients are preservatives or plasticizers; The contents consist of one of sea buckthorn seed oil or fruit oil, sea buckthorn powder, and excipients. The excipient is one or a mixture of two of the following: suspending agent and antioxidant. The sea buckthorn powder is rich in flavonoids, and the soft capsules have the effects of lowering lipids, softening blood vessels, and preventing vascular diseases.

2. The sea buckthorn soft capsule according to claim 1, characterized in that: The mass ratio of gelatin, water and glycerin in the capsule shell is 1:1:1, and the preservative is ethylparaben, added at a rate of 0.01-0.1% of the total mass of the capsule shell.

3. The sea buckthorn soft capsule according to claim 1, characterized in that: The contents contain 3-8 parts of sea buckthorn seed oil or fruit oil and 0.5-1.5 parts of sea buckthorn powder. The suspending agent is beeswax, and the amount added is 0.1-0.5 parts of the total weight of the contents.

4. A sea buckthorn soft capsule according to claim 1, characterized in that: The antioxidant in the contents is vitamin E, and the amount added is 0.05-0.2% of the weight of sea buckthorn seed oil or fruit oil.

5. A sea buckthorn soft capsule according to claim 1, characterized in that: The plasticizer in the capsule shell is sorbitol, and the amount added is 10-20% of the weight of glycerol.

6. The production process of sea buckthorn soft capsules according to any one of claims 1-5, characterized in that: The production process includes the following steps: S1. Gelatinizing: Gelatin, water, glycerin and capsule excipients are added to a gelatinizing tank at a mass ratio of gelatin:water:glycerin = 1:1:

1. Stir at 70-80℃ until completely dissolved, and degas to obtain the gel solution. S2. Preparation of contents: Take 3-8 parts by weight of sea buckthorn seed oil or fruit oil, heat to 40-50℃, add 0.5-1.5 parts of sea buckthorn powder and contents excipients, stir and mix evenly to obtain contents; S3, Capsule pressing: The gelatin solution and contents are pumped into a fully automatic capsule pressing machine, the temperature of the gelatin solution is controlled at 60-70℃ and the temperature of the contents is controlled at 40-50℃, and capsules are pressed to obtain the initial capsules. S4. Washing the capsules: Quickly rinse the surface oil stains of the pre-processed capsules with 95% ethanol and drain. S5. Drying: Place the washed capsules into a rotary dryer and dry them at 100-140℃ for 10-20 hours. S6. Sorting: Remove deformed or leaking unqualified capsules; S7. Packaging: Dispense and seal the qualified capsules.

7. The production process of sea buckthorn soft capsules according to claim 6, characterized in that: The stirring speed in S1 is 50-100 r / min, and the degassing vacuum degree is -0.06 to -0.08 MPa.

8. The production process of sea buckthorn soft capsules according to claim 6, characterized in that: The stirring time in S2 is 30-60 minutes, and the stirring speed is 150-200 r / min.

9. The production process of sea buckthorn soft capsules according to claim 6, characterized in that: The drying process in S5 adopts a gradient temperature increase, first drying at 100-110℃ for 5-8 hours, and then drying at 120-140℃ for 5-12 hours.

10. The production process of sea buckthorn soft capsules according to claim 6, characterized in that: The relative humidity of the packaging environment in S7 is controlled at 30-45%.