Process and device for continuously extracting gibberellic acid
By using multi-stage membrane separation and solvent extraction technology in a continuous extraction device, the problems of high labor requirements, high energy consumption, and easy degradation of active ingredients in traditional gibberellic acid extraction have been solved, achieving efficient and low-cost gibberellic acid extraction.
Patent Information
- Application Number
- CN202510798267.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-16
- Publication Date
- 2025-11-07
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Traditional gibberellic acid extraction processes require a large amount of manual labor, pose chemical hazard risks, consume a lot of energy, and the active ingredients are easily degraded at high temperatures, resulting in long process cycles.
The continuous extraction device includes pressure filtration, filtration, sealing, reaction, clamping, liquid addition and cooling mechanisms, combined with multi-stage membrane separation and solvent extraction, to achieve fully automated control of the process, reduce manual intervention and lower energy consumption.
It improves extraction efficiency and product purity, reduces production costs and waste emissions, and is suitable for large-scale industrial production.
Smart Images
Figure CN120900299A_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the technical field of gibberellic acid extraction, and more particularly to a continuous gibberellic acid extraction process and device. BACKGROUND
[0002] Gibberellic acid is a kind of gibberellin, and is a widely used gibberellin compound. Gibberellic acid is a broad-spectrum plant growth regulator, which can promote crop growth and development, make it mature early, improve yield and quality, break the dormancy of seeds, tubers and bulbs, promote germination, and play a low-temperature vernalization and long-day role to promote and induce long-day vegetable crops to flower in the same year, improve fruit setting rate or form seedless fruits. The traditional extraction process requires a large amount of manual work, increases the labor intensity, and a large amount of chemicals appear in the extraction process, which is easy to cause harm to the workers. In addition, the traditional concentration process causes degradation of active ingredients due to high temperature and uneven local heating. The evaporation process needs to maintain high vacuum degree, and the latent heat of water evaporation is large, which significantly increases the energy consumption. The intermittent production needs to frequently adjust parameters, and the process cycle is long. SUMMARY
[0003] 1. Technical problem to be solved In view of the problems in the prior art, the purpose of the present application is to provide a continuous gibberellic acid extraction process and device. The present application can reduce the probability of manual contact and reduce the energy consumption of extraction on the basis of realizing continuous gibberellic acid extraction.
[0004] 2. Technical scheme To solve the above problems, the present application adopts the following technical scheme: A continuous gibberellic acid extraction device, comprising: a mounting frame, one side of the mounting frame is provided with a filter pressing mechanism, the bottom of the filter pressing mechanism is provided with a filtering mechanism, the surface of the mounting frame is provided with a sealing mechanism, the surface of the mounting frame is provided with a reaction mechanism, the surface of the mounting frame is provided with a clamping mechanism matched with the reaction mechanism, the inner side of the mounting frame is provided with a liquid adding mechanism, and one side of the mounting frame is provided with a cooling mechanism.
[0005] As a preferred embodiment of the present application, the filter pressing mechanism comprises a filter pressing frame arranged on one side of the mounting frame, two horizontally extending guide rods are arranged on the surface of the filter pressing frame, a plurality of filter plates are slidably connected to the surface of the guide rods, a first electric cylinder for horizontal adjustment is arranged on one side of the surface of the filter pressing frame, a pressing plate is arranged on the surface of the piston rod of the first electric cylinder, a feeding plate is arranged on the other side of the surface of the filter pressing frame, a first booster pump is arranged on the surface of the filter pressing frame, the first booster pump and the feeding plate are communicated through a first liquid conveying pipe, and a filter plate matched with the filter plate is arranged on the surface of the filter pressing frame.
[0006] As a preferred scheme of the present application, the filtering mechanism comprises a filter frame arranged between the mounting frame and the filter frame, the surface of the filter frame is fixedly connected with a first filter pipe and a second filter pipe, the first filter pipe and the second filter pipe are communicated through a plurality of connecting valves, the inside of the first filter pipe and the second filter pipe is sequentially provided with a first filter screen, a second filter screen and a plurality of third filter screens, the surface of the filter frame is provided with a second booster pump, and the liquid inlet end and the liquid outlet end of the second booster pump are respectively communicated with the bottom and one end of the first filter pipe; The first filter screen is a 30-50kDa membrane, the second filter screen is a 4-6kDa membrane, and the third filter screen is a 50-200Da membrane.
[0007] As a preferred scheme of the present application, the sealing mechanism comprises two second electric cylinders and a third booster pump mounted on the surface of the mounting frame, the surface of the piston rod of the moving frame is provided with a moving frame, the bottom of the moving frame is provided with a sealing cover, the surface of the sealing cover is provided with a servo motor, the surface of the output shaft of the servo motor and below the sealing cover are rotatably connected with a stirring paddle, the surface of the sealing cover is provided with a pressure sensor, the liquid inlet end of the third booster pump is communicated with the first filter pipe, the surface of the liquid outlet end of the third booster pump is provided with a second infusion pipe, and the surface of one end of the outer side of the second infusion pipe is provided with a first control valve.
[0008] As a preferred scheme of the present application, the reaction mechanism comprises a protective shell arranged on the surface of the mounting frame, the inner wall of the protective shell is provided with a heating inner container, the inside of the protective shell is provided with two groups of heaters for heating the heating inner container, and the surface of the heating inner container is provided with a reaction barrel.
[0009] As a preferred scheme of the present application, the clamping mechanism comprises a clamping seat mounted on the surface of the mounting frame, the surface of the clamping seat is rotatably connected with two connecting rods, one end of the outer side of the connecting rod is rotatably connected with a first clamping plate, the surface of the clamping seat is rotatably connected with two third electric cylinders, the piston rods of the two third electric cylinders are rotatably connected with the two connecting rods respectively, the surface of the clamping seat is provided with a supporting frame, the lower surface of the supporting frame is provided with a spring telescopic rod, one end of the outer side of the spring telescopic rod is provided with a second clamping plate, and the surface of the clamping seat is rotatably connected with a rotating supporting plate matched with the second infusion pipe.
[0010] As a preferred scheme of the present application, the liquid adding mechanism comprises a bracket mounted on the surface of the mounting frame, the surface of the bracket is provided with a storage box, one end of the outer side of the storage box is rotatably connected with a second control valve, the bottom of the second control valve is provided with a spraying head, the surface of the storage box is provided with two third infusion pipes, and the surface of the third infusion pipe is provided with a third control valve.
[0011] As a preferred scheme of the present application, the cooling mechanism comprises a cooling tower arranged on one side of the mounting frame, a condensing pipe is arranged in the cooling tower, a liquid adding pipe is arranged on the surface of the cooling tower, a fourth infusion pipe matched with the sealing cover is arranged at the upper end of the condensing pipe, a fourth control valve is arranged on the surface of the fourth infusion pipe, a liquid discharge faucet is arranged at one end of the bottom of the condensing pipe, a first collecting barrel is arranged on one side of the cooling tower, and a second collecting barrel is arranged on one side of the first collecting barrel.
[0012] A continuous gibberellic acid extraction process, comprising the steps of: S1, pretreatment and filtration: using HCL to adjust the pH of the fermentation liquor to 2.5-3.0, and adding polyaluminum chloride as a flocculant to promote the precipitation of impurities, filtering under a pressure of 0.2-0.6 MPa through a pressure filtration mechanism, separating the filtrate and the residue, and then performing multi-stage continuous concentration to reduce the volume and increase the gibberellic acid concentration. S2, extraction: delivering the solution into the reaction mechanism, then adding ethyl acetate as an extractant into the solution through a liquid adding mechanism, adjusting the pH value to 2.5, adding sodium dodecyl sulfonate to promote the separation, then closing the reaction mechanism through a sealing mechanism and stirring to accelerate the separation.
[0013] S3, crystallization and purification: heating the solution through the reaction mechanism, and performing vacuum evaporation at a temperature of 40-55 DEG C twice and a vacuum degree of -0.08~-0.06 MPa, then precipitating the gibberellic acid crystals through cooling, continuously separating GA3 using a styrene-divinylbenzene skeleton adsorption resin, eluting with a methanol-water mixture, and then dissolving the coarse crystals, decolorizing through activated carbon, filtering, and then crystallizing again to improve the purity. S4, drying and finished product processing: after crystallization, removing the mother liquor through a centrifuge with a power of 3000 r / min, boiling drying the crystals at 70 DEG C, and finally crushing the crystals to obtain gibberellic acid powder.
[0014] 3. Beneficial effects Compared with the prior art, the present application has the following advantages: (1) The solution is filtered through the pressure filtration mechanism, concentrated through the filtration mechanism, then stored through the reaction mechanism, the reaction solution is added into the reaction mechanism through the liquid adding mechanism, then the solution in the reaction mechanism is mixed through the sealing mechanism, and the solution is heated and concentrated through the reaction mechanism, and the generated gas is collected through the cooling mechanism.
[0015] (2) The present application can improve the extraction efficiency through the cooperation of the filter pressing mechanism and the filtering mechanism, improve the purity of the product through the multi-stage membrane separation of the filtering mechanism combined with solvent extraction optimization, replace high-temperature evaporation with nanofiltration concentration, reduce energy consumption, increase solvent recovery rate, reduce production cost and waste discharge, maintain the stability of the fermentation liquid through automatic flow addition, reduce manual intervention, integrate membrane separation, extraction and concentration devices, realize full-process automatic control, and is suitable for large-scale industrial production. BRIEF DESCRIPTION OF DRAWINGS
[0016] Figure 1 It is a schematic view of the continuous extraction device for gibberellic acid of the present application; Figure 2 It is a schematic view of the filter pressing mechanism in the continuous extraction device for gibberellic acid of the present application; Figure 3 It is a schematic view of the filtering mechanism in the continuous extraction device for gibberellic acid of the present application; Figure 4 It is a schematic view of the sealing mechanism in the continuous extraction device for gibberellic acid of the present application; Figure 5 It is a schematic view of the reaction mechanism in the continuous extraction device for gibberellic acid of the present application; Figure 6 It is a schematic view of the clamping mechanism in the continuous extraction device for gibberellic acid of the present application; Figure 7 It is a schematic view of the liquid adding mechanism in the continuous extraction device for gibberellic acid of the present application; Figure 8 It is a schematic view of the cooling mechanism in the continuous extraction device for gibberellic acid of the present application.
[0017] Explanation of reference numerals in the drawings: 1, mounting frame; 2, filter pressing mechanism; 201, filter pressing frame; 202, guide rod; 203, filter plate; 204, first electric cylinder; 205, pressing plate; 206, first booster pump; 207, first liquid conveying pipe; 208, feeding plate; 3, filtering mechanism; 301, filter frame; 302, first filter pipe; 303, second filter pipe; 304, connecting valve; 305, first filter screen; 306, second filter screen; 307, third filter screen; 308, second booster pump; 4, sealing mechanism; 401, second electric cylinder; 402, moving frame; 403, sealing cover; 404, servo motor; 405, stirring paddle; 406, third booster pump; 407, second liquid conveying pipe; 408, first control valve; 5, reaction mechanism; 501, protective shell; 502, heating inner container; 503, heater; 504, reaction bucket; 6, clamping mechanism; 601, clamping seat; 602, connecting rod; 603, first clamping plate; 604, third electric cylinder; 605, support frame; 606, spring telescopic rod; 607, second clamping plate; 608, rotating supporting plate; 7, liquid adding mechanism; 701, bracket; 702, storage box; 703, second control valve; 704, spraying head; 705, third liquid conveying pipe; 706, third control valve; 8, cooling mechanism; 801, cooling tower; 802, condenser pipe; 803, liquid adding pipe; 804, fourth liquid conveying pipe; 805, fourth control valve; 806, liquid discharge faucet; 807, first collection bucket; 808, second collection bucket. DETAILED DESCRIPTION
[0018] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, and all other embodiments obtained by a person of ordinary skill in the art without creative labor on the basis of the embodiments in the present application shall fall within the scope of protection of the present application.
[0019] Embodiment: Please refer to Figures 1-8 A continuous gibberellin extraction device, comprising: a mounting frame 1, one side of the mounting frame 1 is provided with a filter pressing mechanism 2, the bottom of the filter pressing mechanism 2 is provided with a filtering mechanism 3, the surface of the mounting frame 1 is provided with a sealing mechanism 4, the surface of the mounting frame 1 is provided with a reaction mechanism 5, the surface of the mounting frame 1 is provided with a clamping mechanism 6 adapted to the reaction mechanism 5, the inner side of the mounting frame 1 is provided with a liquid adding mechanism 7, and one side of the mounting frame 1 is provided with a cooling mechanism 8.
[0020] In the specific embodiment of the present application, the solution is filtered by the pressure filtration mechanism 2, concentrated by nanofiltration by the filtration mechanism 3, then stored by the reaction mechanism 5, the reaction solution is added to the inside of the reaction mechanism 5 by the liquid adding mechanism 7, then the solution inside the reaction mechanism 5 is mixed by the sealing mechanism 4, at the same time the solution is heated and concentrated by the reaction mechanism 5, the generated gas is collected by the cooling mechanism 8, the use of the pressure filtration mechanism 2 and the filtration mechanism 3 can improve the extraction efficiency, the use of multi-stage membrane separation combined with solvent extraction optimization by the filtration mechanism 3 can improve the purity of the product, nanofiltration concentration instead of high-temperature evaporation can reduce energy consumption, increase solvent recovery rate, reduce production cost and waste emission, automatic flow addition can maintain the stability of the fermentation broth, reduce manual intervention, integrated membrane separation, extraction and concentration device can realize full-process automatic control, which is suitable for large-scale industrial production.
[0021] Specifically, the pressure filtration mechanism 2 comprises a pressure filtration frame 201 arranged on one side of the mounting frame 1, two horizontally extending guide rods 202 are mounted on the surface of the pressure filtration frame 201, a plurality of filter plates 203 are slidably connected to the surface of the guide rods 202, a first electric cylinder 204 for horizontal adjustment is mounted on one side of the surface of the pressure filtration frame 201, a pressing plate 205 is mounted on the surface of the piston rod of the first electric cylinder 204, a feeding plate 208 is mounted on the other side of the surface of the pressure filtration frame 201, a first booster pump 206 is mounted on the surface of the pressure filtration frame 201, the first booster pump 206 and the feeding plate 208 are communicated through a first liquid conveying pipe 207, and 209 corresponding to the filter plates 203 is mounted on the surface of the pressure filtration frame 201.
[0022] In the specific embodiment of the present application, the solution enters the inside of the feeding plate 208 and the filter plate 203 under the action of the first booster pump 206 and the first liquid conveying pipe 207, then the first electric cylinder 204 starts to extend the piston rod to drive the pressing plate 205 to press the plurality of filter plates 203, at this time the liquid falls into the inside of 209 and the solid accumulates into blocks in the inside of the filter plate 203.
[0023] Specifically, the filtration mechanism 3 comprises a filtration frame 301 arranged between the mounting frame 1 and the pressure filtration frame 201, the surface of the filtration frame 301 is fixedly connected with a first filter pipe 302 and a second filter pipe 303, the first filter pipe 302 and the second filter pipe 303 are communicated through a plurality of connection valves 304, the inside of the first filter pipe 302 and the second filter pipe 303 are sequentially provided with a first filter screen 305, a second filter screen 306 and a plurality of third filter screens 307, a second booster pump 308 is mounted on the surface of the filtration frame 301, the liquid inlet end and the liquid outlet end of the second booster pump 308 are respectively communicated with the bottom of 209 and one end of the first filter pipe 302, the first filter screen 305 is a 30-50 kDa membrane, the second filter screen 306 is a 4-6 kDa membrane, and the third filter screen 307 is a 50-200 Da membrane.
[0024] In the embodiment of the present application, the liquid of 209 is pressurized by the second booster pump 308 and delivered to the inside of the first filter pipe 302, at this time, the first filter screen 305 removes large particle impurities, the second filter screen 306 separates medium molecular weight impurities, and the third filter screen 307 further concentrates the target product, when the first filter screen 305 or the second filter screen 306 is blocked, the connecting valve 304 will move the liquid in the inside of the first filter pipe 302 to the inside of the second filter pipe 303 and continue to filter.
[0025] Specifically, the sealing mechanism 4 comprises two second electric cylinders 401 and a third booster pump 406 installed on the surface of the mounting frame 1, the surface of the piston rod of the moving frame 402 is installed with the moving frame 402, the bottom of the moving frame 402 is installed with the sealing cover 403, the surface of the sealing cover 403 is installed with the servo motor 404, the surface of the output shaft of the servo motor 404 and below the sealing cover 403 is rotatably connected with the stirring paddle 405, the surface of the sealing cover 403 is installed with the pressure sensor, the liquid inlet end of the third booster pump 406 is communicated with the first filter pipe 302, the surface of the liquid outlet end of the third booster pump 406 is provided with the second liquid delivery pipe 407, and the surface of one end outside of the second liquid delivery pipe 407 is provided with the first control valve 408.
[0026] In the embodiment of the present application, the liquid in the inside of the first filter pipe 302 is delivered to the inside of the reaction barrel 504 under the action of the third booster pump 406, the second liquid delivery pipe 407 and the first control valve 408, the piston rod of the second electric cylinder 401 is started to drive the moving frame 402 and the sealing cover 403 to descend, at this time, the reaction barrel 504 can be sealed by the sealing cover 403, the output shaft of the servo motor 404 is started to drive the stirring paddle 405 to rotate, so as to mix the solution in the inside of the reaction barrel 504.
[0027] Specifically, the reaction mechanism 5 comprises the protective shell 501 arranged on the surface of the mounting frame 1, the inner wall of the protective shell 501 is provided with the heating inner container 502, the inside of the protective shell 501 is installed with two groups of heaters 503 for heating the heating inner container 502, and the surface of the heating inner container 502 is provided with the reaction barrel 504.
[0028] In the embodiment of the present application, the heating inner container 502 can be heated by the heater 503, so as to heat the reaction barrel 504.
[0029] Specifically, the clamping mechanism 6 comprises a clamping seat 601 mounted on the surface of the mounting frame 1, the surface of the clamping seat 601 is rotatably connected with two connecting rods 602, one end of the outer side of the connecting rod 602 is rotatably connected with a first clamping plate 603, the surface of the clamping seat 601 is rotatably connected with two third electric cylinders 604, and the piston rods of the two third electric cylinders 604 are rotatably connected with the two connecting rods 602 respectively, the surface of the clamping seat 601 is mounted with a supporting frame 605, the lower surface of the supporting frame 605 is mounted with a spring telescopic rod 606, one end of the outer side of the spring telescopic rod 606 is mounted with a second clamping plate 607, and the surface of the clamping seat 601 is rotatably connected with a rotating supporting plate 608 adapted to the second liquid conveying pipe 407.
[0030] In specific embodiments of the present application, the rotating supporting plate 608 is used to support the second liquid conveying pipe 407 and adjust the angle of the second liquid conveying pipe 407, when the third electric cylinder 604 is started, the piston rod thereof drives the connecting rod 602 to move, and the connecting rod 602 drives the first clamping plate 603 to move, at this time, the reaction bucket 504 is limited under the action of the first clamping plate 603 and the second clamping plate 607, thereby reducing the probability of shaking of the reaction bucket 504 due to stirring.
[0031] Specifically, the liquid adding mechanism 7 comprises a bracket 701 mounted on the surface of the mounting frame 1, the surface of the bracket 701 is provided with a storage box 702, the bottom of the storage box 702 is rotatably connected with a second control valve 703, the bottom of the second control valve 703 is mounted with a spray head 704, the surface of the storage box 702 is provided with two third liquid conveying pipes 705, and the surface of the third liquid conveying pipe 705 is provided with a third control valve 706.
[0032] In specific embodiments of the present application, the reaction liquid can be added into the inside of the storage box 702 through the third control valve 706 and the third liquid conveying pipe 705, and the inside of the reaction bucket 504 is added with the reaction liquid by the storage box 702 through the second control valve 703 and the spray head 704.
[0033] Specifically, the cooling mechanism 8 comprises a cooling tower 801 arranged on one side of the mounting frame 1, the inside of the cooling tower 801 is provided with a condensing pipe 802, the surface of the cooling tower 801 is provided with a liquid adding pipe 803, the upper end of the condensing pipe 802 is provided with a fourth liquid conveying pipe 804 adapted to the sealing cover 403, the surface of the fourth liquid conveying pipe 804 is provided with a fourth control valve 805, one end of the bottom of the condensing pipe 802 is provided with a liquid drain cock 806, one side of the cooling tower 801 is provided with a first collection bucket 807, and one side of the first collection bucket 807 is provided with a second collection bucket 808.
[0034] In the specific embodiments of the present application, the hot gas generated by heating the reaction bucket 504 enters the inside of the condensing pipe 802 through the fourth liquid delivery pipe 804, at which time the hot gas is cooled under the action of the cooling tower 801 and the condensing pipe 802, and the cooled liquid flows into the inside of the first collection bucket 807 through the liquid outlet faucet 806 for collection.
[0035] A continuous gibberellic acid extraction process, comprising the following steps: S1, pretreatment and filtration: using HCL to adjust the pH of the fermentation liquor to 2.5-3.0, and adding polyaluminum chloride as a flocculant to promote the precipitation of impurities, filtering through a pressure filtration mechanism 2 under a pressure of 0.2-0.6 MPa, separating the residue and the filtrate, the filtrate entering a filtration mechanism 3, removing large particle impurities and separating medium molecular weight through the filtration mechanism 3, and then performing multi-stage continuous concentration to reduce the volume and increase the gibberellic acid concentration; S2, extraction: delivering the solution into the inside of a reaction mechanism 5, then adding ethyl acetate as an extractant into the solution through a liquid adding mechanism 7, and adding HCL to adjust the pH value to 2.5, adding sodium dodecyl sulfonate to promote layering, then closing the reaction mechanism 5 through a sealing mechanism 4 and stirring to accelerate layering.
[0036] S3, crystallization and purification: heating the solution through the reaction mechanism 5, and using twice temperature of 40-55℃, vacuum degree of -0.08~-0.06 MPa to reduce pressure evaporation, precipitating gibberellic acid crystals through cooling, using styrene-divinylbenzene skeleton adsorption resin to continuously separate GA3, methanol-water mixed solution elution, after the crude crystal is dissolved, decolorizing and filtering through activated carbon, and then reducing temperature to crystallize to improve purity; S4, drying and finished product processing: after crystallization, using a centrifuge with a power of 3000 r / min to remove the mother liquor, boiling the crystallization at 70℃ for drying, and finally crushing the crystallization to obtain gibberellic acid powder.
[0037] The above is only the preferred specific embodiment of the present application, but the protection scope of the present application is not limited thereto, any person skilled in the art can make equivalent replacement or change according to the technical solution and improvement concept of the present application within the technical range disclosed by the present application, which should be covered in the protection scope of the present application.
Claims
1. A device for continuous extraction of gibberellic acid, characterized by, Include: The installation frame (1), one side of the installation frame (1) is provided with filter press mechanism (2), the bottom of filter press mechanism (2) is provided with filter mechanism (3), the surface of installation frame (1) is mounted with sealing mechanism (4), the surface of installation frame (1) is provided with reaction mechanism (5), the surface of installation frame (1) is provided with clamping mechanism (6) adapted to reaction mechanism (5), the inner side of installation frame (1) is mounted with liquid adding mechanism (7), one side of installation frame (1) is provided with cooling mechanism (8).
2. The device for continuous extraction of gibberellic acid according to claim 1, characterized in that, The filter press mechanism (2) includes a filter press frame (201) disposed on one side of the installation frame (1), two horizontally extending guide rods (202) are mounted on the surface of the filter press frame (201), a plurality of filter plates (203) are slidably connected to the surface of the guide rods (202), a first electric cylinder (204) for horizontal adjustment is mounted on one side of the surface of the filter press frame (201), a compression plate (205) is mounted on the surface of the piston rod of the first electric cylinder (204), an inlet plate (208) is mounted on the surface of the other side of the filter press frame (201), a first booster pump (206) is mounted on the surface of the filter press frame (201), the first booster pump (206) is in communication with the inlet plate (208) through a first liquid delivery pipe (207), and a filter plate (209) adapted to the filter plate (203) is mounted on the surface of the filter press frame (201).
3. The device for continuous extraction of gibberellic acid according to claim 2, characterized in that, The filter mechanism (3) includes a filter frame (301) disposed between the installation frame (1) and the filter press frame (201), the surface of the filter frame (301) is fixedly connected with a first filter pipe (302) and a second filter pipe (303), the first filter pipe (302) and the second filter pipe (303) are in communication through a plurality of connection valves (304), the inside of the first filter pipe (302) and the second filter pipe (303) are sequentially provided with a first filter screen (305), a second filter screen (306) and a plurality of third filter screens (307), a second booster pump (308) is mounted on the surface of the filter frame (301), and the liquid inlet end and the liquid outlet end of the second booster pump (308) are in communication with the bottom of (209) and one end of the first filter pipe (302), respectively. The first filter screen (305) is a 30-50kDa membrane, the second filter screen (306) is a 4-6kDa membrane, and the third filter screen (307) is a 50-200Da membrane.
4. The device for continuous extraction of gibberellic acid according to claim 3, characterized in that, The sealing mechanism (4) includes two second electric cylinders (401) and a third booster pump (406) installed on the surface of the mounting frame (1), the surface of the piston rod of the moving frame (402) is installed with the moving frame (402), the bottom of the moving frame (402) is installed with a sealing cover (403), the surface of the sealing cover (403) is installed with a servo motor (404), the surface of the output shaft of the servo motor (404) and below the sealing cover (403) is rotatably connected with a stirring paddle (405), the surface of the sealing cover (403) is installed with a pressure sensor, the liquid inlet end of the third booster pump (406) is communicated with the first filter pipe (302), the surface of the liquid outlet end of the third booster pump (406) is provided with a second liquid outlet pipe (407), and the surface of one end of the outer side of the second liquid outlet pipe (407) is provided with a first control valve (408).
5. The device for continuous extraction of gibberellic acid according to claim 4, characterized in that, The reaction mechanism (5) includes a protective shell (501) arranged on the surface of the mounting frame (1), and the inner wall of the protective shell (501) is provided with a heating inner container (502). The protective shell (501) is internally provided with two groups of heaters (503) for heating the heating inner container (502), and the surface of the heating inner container (502) is provided with a reaction barrel (504).
6. The device for continuous extraction of gibberellic acid according to claim 5, characterized in that, The clamping mechanism (6) includes a clamping seat (601) installed on the surface of the mounting frame (1), the surface of the clamping seat (601) is rotatably connected with two connecting rods (602), one end of the outer side of the connecting rod (602) is rotatably connected with a first clamping plate (603), the surface of the clamping seat (601) is rotatably connected with two third electric cylinders (604), and the piston rods of the two third electric cylinders (604) are rotatably connected with the two connecting rods (602) respectively, the surface of the clamping seat (601) is installed with a supporting frame (605), the lower surface of the supporting frame (605) is installed with a spring telescopic rod (606), one end of the outer side of the spring telescopic rod (606) is installed with a second clamping plate (607), and the surface of the clamping seat (601) is rotatably connected with a rotating supporting plate (608) matched with the second liquid outlet pipe (407).
7. The device for continuous extraction of gibberellic acid according to claim 6, characterized in that, The liquid adding mechanism (7) includes a bracket (701) installed on the surface of the mounting frame (1), the surface of the bracket (701) is provided with a storage box (702), the bottom of the storage box (702) is rotatably connected with a second control valve (703), the bottom of the second control valve (703) is installed with a spray head (704), the surface of the storage box (702) is provided with two third liquid outlet pipes (705), and the surface of the third liquid outlet pipe (705) is provided with a third control valve (706).
8. The device for continuous extraction of gibberellic acid according to claim 7, characterized in that, The cooling mechanism (8) includes a cooling tower (801) arranged on one side of the mounting frame (1), the inside of the cooling tower (801) is provided with a condensing pipe (802), the surface of the cooling tower (801) is provided with a liquid adding pipe (803), the upper end of the condensing pipe (802) is provided with a fourth infusion pipe (804) matched with the sealing cover (403), the surface of the fourth infusion pipe (804) is provided with a fourth control valve (805), one end of the bottom of the condensing pipe (802) is provided with a liquid drain faucet (806), one side of the cooling tower (801) is provided with a first collection barrel (807), one side of the first collection barrel (807) is provided with a second collection barrel (808).
9. A continuous gibberellic acid extraction process applied to the continuous gibberellic acid extraction device according to claims 1-8, characterized in that, The method comprises the following steps: S1, pretreatment and filtration: the pH of the fermentation liquid is adjusted to 2.5-3.0 by using HCL, and the polyaluminum chloride is added to promote the precipitation of impurities, and the filtration mechanism (2) is used to filter under the pressure of 0.2-0.6 MPa, so as to separate the residue and the filtrate, the filtrate enters the filtration mechanism (3), the large particle impurities are removed and the medium molecular weight is separated, and then the multi-stage continuous concentration is carried out, so as to reduce the volume and increase the concentration of the GA3; S2, extraction: the solution is transported into the reaction mechanism (5), then the ethyl acetate is added into the solution as an extractant by using the liquid adding mechanism (7), the pH value is adjusted to 2.5, the sodium dodecyl sulfonate is added to promote the separation, then the reaction mechanism (5) is closed by the sealing mechanism (4) and is stirred to accelerate the separation. S3, crystallization and purification: the solution is heated by the reaction mechanism (5), the vacuum evaporation is carried out twice at the temperature of 40-55℃ and the vacuum degree of-0.08~-0.06 MPa, the GA3 is separated by using the styrene-divinyl benzene skeleton adsorption resin, the methanol-water mixed solution is used for elution, the crude crystal is dissolved and is filtered by using the activated carbon to decolorize, then the crystallization is carried out to improve the purity; S4, drying and finished product treatment: the mother liquor is removed by using the centrifuge with the power of 3000 r / min after the crystallization, the crystallization is boiled and dried at 70℃, and finally the crystallization is crushed to obtain the GA3 powder.