A multi-photon fiber array endoscopic imaging device and method based on hollow helical scanning

By employing hollow spiral scanning and image fusion technology, the problems of central light damage and resolution inhomogeneity in traditional multiphoton microendoscopy have been solved, achieving low-light-damage, high-resolution multiphoton endoscopic imaging.

CN120918554BActive Publication Date: 2026-02-06SHENZHEN UNIV
2 Cites 0 Cited by

Patent Information

Application Number
CN202511454506.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-10-13
Publication Date
2026-02-06
Estimated Expiration
2045-10-13

AI Technical Summary

Technical Problem

Traditional multiphoton microendoscopy with spiral scanning suffers from severe light damage in the central region and uneven image resolution, problems that existing optimization schemes cannot fundamentally solve.

Method used

An endoscopic imaging device based on hollow spiral scanning multiphoton fiber array is used. By designing a hollow spiral scanning trajectory to avoid dense sampling in the central region, and by executing complementary hollow spiral trajectories through multiple fibers in the fiber array, combined with image fusion technology, uniform sampling across the entire field of view is achieved.

Benefits of technology

It significantly reduces the risk of central light damage, improves the uniformity of imaging resolution and the reliability of images, while simplifying system control and improving system reliability and multimodal imaging capabilities.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The application discloses a kind of multi-photon fiber array endoscopic imaging device and method based on hollow spiral scanning, belong to biological imaging technical field.The device includes laser collimation and beam expansion module, pulse chirp module, beam switching module, endoscopic detection module and fluorescence acquisition module.The beam switching module contains optical switch and at least two low group velocity dispersion single-mode fiber array;Endoscopic detection module drives fiber array to perform hollow spiral scanning by resonant driver, its track starting point is not located at the origin of field of view, to avoid central dense sampling.The method switches fiber by optical switch, so that each fiber performs spatial non-overlapping hollow spiral scanning, collects multi-photon signals such as fluorescence, second harmonic and fluorescence lifetime, and completes the central cavity by image reconstruction and fusion, to obtain complete field of view imaging result.The application significantly reduces the central region light damage, improves the uniformity of imaging resolution, and the fused image is based on physical sampling to ensure authenticity and reliability, with high system stability.
Need to check novelty before this filing date? Find Prior Art