Spray freeze-drying system

Abstract

The application provides a spray freeze drying system. The spray freeze drying system comprises a spray freezing device having a spray freezing chamber and a material receiving port, the material receiving port being located at the bottom of the spray freezing chamber and being in communication with the spray freezing chamber, and the material receiving port being used for outputting frozen material; a vacuum freeze drying device comprising a freeze drying bin and a plurality of material supporting members, the freeze drying bin having a freeze drying chamber used for vacuum freeze drying of material, and the plurality of material supporting members being movably placed in the freeze drying chamber; and a conveying device used for conveying the material supporting members, so that any one of the plurality of material supporting members has a first position located below the material receiving port and a second position located in the freeze drying chamber, and when the material supporting member is in the first position, one side of the material supporting member used for supporting material is in sealing cooperation with the material receiving port. The technical scheme of the application solves the problem that the spray freeze drying system in the prior art is difficult to be enlarged for production.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of spray freeze-drying technology, in particular, to a spray freeze-drying system. BACKGROUND

[0002] In the pharmaceutical field, freeze-drying is an important means for preserving heat-sensitive drugs, biological agents and vaccines, etc. Drugs treated by freeze-drying can maintain certain activity and stability, extend their effective period and shelf life, and have an irreplaceable role in the production and storage of some high-value biological drugs and vaccines. With the rapid development of the biological and pharmaceutical industry, the demand for freeze-drying technology is also growing. In addition, researchers often need to use freeze-drying technology for processing in the preservation of biological samples, the preservation of microbial strains, genetic engineering research, etc. in order to preserve and transport biological samples for a long time, while ensuring the activity and integrity of the samples, providing important support for the smooth progress of scientific research.

[0003] However, there are still many problems in the freeze-drying industry that are difficult to solve, such as: the investment in freeze-drying equipment is too large, including the equipment itself, auxiliary equipment such as vacuum pumps and condensers, and the cost of installing the equipment, and the operation and maintenance cost of the equipment is also high, requiring regular replacement of vacuum pump oil, calibration of sensors, etc.; the drying time is too long, shortening the drying time to several hours, longening the drying time to several days, or even longer, and the production efficiency is relatively low. Compared with other drying methods such as spray drying, the slow drying speed will become a bottleneck for expanding production; the degree of integration is low, and the existing freeze-drying machines on the market all need manual operation for manual loading and unloading, which sometimes even takes several hours in the actual production process, and the participation of manual labor is too high and the overall integration of the equipment is too low.

[0004] Spray freeze-drying technology can solve some of the above problems. Spray freeze-drying (SFD) is a technology that combines spray freezing and vacuum freeze-drying, mainly used for processing heat-sensitive, easily oxidized or requiring to maintain specific structures (such as porosity, high solubility) substances. Its core principle is to first atomize the liquid material into small droplets and freeze them instantly, then remove the ice crystals by sublimation under vacuum conditions, and finally obtain dry powder. It can greatly shorten the drying time and improve the drying efficiency, but spray freeze-drying has a fatal flaw, i.e. low production capacity and difficulty in automation.

[0005] A vacuum spray freeze-drying machine is disclosed in Chinese Patent Publication No. CN115289788B, which includes a feeding device and a vacuum drying device. The feeding device includes a feeding pump and a pretreatment mechanism. The pretreatment mechanism is connected to the feeding pump and the vacuum drying device. The pretreatment mechanism is used for pre-cooling the material. The vacuum drying device includes a quartz glass cover and a plurality of annular infrared heaters. The annular infrared heaters are arranged on the outer wall of the quartz glass cover to form a heating sublimation zone inside the quartz glass cover. The material is pre-cooled by the pretreatment mechanism to make the temperature of the material closer to the freezing point of the material. After entering the vacuum drying device, the material is more fully solidified into small ice crystals in the heat exchange zone. Then, the small ice crystals fall through the heating sublimation zone and are dried by the annular infrared heaters. This avoids uneven heating and low heat exchange efficiency. Although the above technology can realize continuous operation in the whole process, it still has many technical drawbacks that restrict actual application and capacity improvement. For example, the heat exchange zone and the heating sublimation zone are in the same vacuum system. Under the action of vacuum suction, the just atomized liquid droplets will accelerate through the heat exchange zone and the heating sublimation zone. If the flow rate is increased to increase the capacity, the time of the liquid droplets staying in the freezing and freeze-drying areas will become shorter, and the freeze-drying will be unqualified. Therefore, the feeding flow rate is limited to achieve qualified freeze-drying effect, and the capacity is restricted, making it difficult to scale up production. SUMMARY

[0006] The main purpose of the present application is to provide a spray freeze-drying system to solve the problem of difficult scale-up production of the spray freeze-drying system in the prior art.

[0007] To achieve the above-mentioned purpose, the present application provides a spray freeze-drying system, which comprises: a spray freeze device having a spray freeze chamber and a material receiving port, the material receiving port being located at the bottom of the spray freeze chamber and being in communication with the spray freeze chamber, and the material receiving port being used for outputting frozen material; a vacuum freeze-drying device comprising a freeze-drying bin and a plurality of material supporting members, the freeze-drying bin having a freeze-drying chamber for vacuum freeze-drying of the material, and the plurality of material supporting members being movably placed in the freeze-drying chamber; and a conveying device for conveying the material supporting members, so that any one of the plurality of material supporting members has a first position located below the material receiving port and a second position located in the freeze-drying chamber, and when the material supporting member is in the first position, the side of the material supporting member for supporting the material is in sealing cooperation with the material receiving port.

[0008] Further, the freeze-drying bin has a placing opening in communication with the freeze-drying chamber, the conveying device comprises: a conveying mechanism arranged correspondingly to the material receiving opening and located below the material receiving opening, the conveying mechanism has a conveying part, the conveying part is arranged in the first direction relative to the spray-freezing device and is liftable to enable the conveying part to approach or move away from the material receiving opening; a material moving mechanism located at a side where the placing opening of the freeze-drying bin is located, the material moving mechanism has a material moving part, the material moving part can put back and take out any material supporting member in the freeze-drying chamber; and a conveying mechanism located between the conveying mechanism and the material moving mechanism, the conveying mechanism is used to convey the material supporting member, the material supporting member reciprocates between the first position and the second position through the conveying mechanism, the conveying mechanism and the material moving mechanism, and the first direction is arranged at an angle with the conveying direction of the conveying mechanism.

[0009] Further, the conveying mechanism comprises: a first support; a conveying table, the conveying table forms the conveying part; a first lifting member arranged on the first support, the first lifting member has a first lifting end arranged in the first direction relative to the first support, and the conveying table is connected to the first lifting end; and a first guide member comprising a first guide piece and a first sliding piece, the first guide piece is arranged on the first support, and one end of the first sliding piece is connected to the conveying table and the other end of the first sliding piece is in sliding fit with the first guide piece.

[0010] Further, the conveying mechanism further comprises two clamping members arranged at intervals in the second direction, the first direction, the second direction and the conveying direction of the conveying mechanism are arranged at angles two by two, the clamping member comprises a mounting piece, a screwing piece, a screw rod and a limiting piece, the mounting piece is connected to the conveying part, the screw rod is arranged in the mounting piece and is in threaded fit with the mounting piece, one end of the screw rod is connected to the screwing piece, the other end of the screw rod is rotationally connected to the limiting piece, and the two limiting pieces are arranged oppositely and form a limiting space for limiting the material supporting member.

[0011] Further, the conveying mechanism further comprises a pushing member, the pushing member comprises: a mounting seat arranged on the conveying part, the mounting seat is located at a side of the limiting space away from the conveying mechanism; a driving piece arranged on the mounting seat, the driving piece has a driving end arranged in the conveying direction relative to the mounting seat; and a pushing piece connected to the driving end, the pushing piece can extend into or out of the limiting space.

[0012] Further, a void slot is arranged on a side of the conveying part facing the material receiving opening, the area of the projection region of the material supporting member on the conveying part is greater than the area of the void slot, and the void slot is in the projection region.

[0013] Further, the conveying mechanism comprises a support frame, a first driving part arranged on the support frame, a plurality of first rolling members rotatably arranged on the support frame, the plurality of first rolling members being arranged in sequence along a conveying direction, and the first driving part being configured to drive the plurality of first rolling members to rotate, and a first conveying belt located at an outer periphery of the plurality of first rolling members, the first conveying belt being configured to convey the material supporting member.

[0014] Further, the material moving mechanism comprises a second support frame located below the freeze-drying chamber, a material moving member having a material moving part, a second lifting member arranged on the second support frame, the second lifting member having a second lifting end arranged to be liftable relative to the second support frame along a first direction, the material moving member being connected to the second lifting end, and a second guide member comprising a second guide member and a second sliding member, the second guide member being arranged on the second support frame, one end of the second sliding member being connected to the material moving member, and the other end of the second sliding member being in sliding cooperation with the second guide member.

[0015] Further, the material supporting member is provided with a groove, and the material moving member comprises a mounting frame connected to the second lifting end, a material moving platform arranged on the mounting frame, the material moving platform having a material moving surface configured to move the material supporting member along a conveying direction, an extension member arranged on the mounting frame, the extension member having an extension end arranged to be movable relative to the material moving platform along a second direction, and a material moving part connected to the extension end, the material moving part being configured to cooperate with the groove to enable the material supporting member to be pulled from the freeze-drying chamber to the material moving surface, the material moving part forming the material moving part.

[0016] Further, the material moving platform comprises a second driving part arranged on the mounting frame, a plurality of second rolling members rotatably arranged on the mounting frame, the plurality of second rolling members being arranged in sequence along the conveying direction, and the second driving part being configured to drive the plurality of second rolling members to rotate, and a second conveying belt located at an outer periphery of the plurality of second rolling members, an upward side of the second conveying belt forming the material moving surface.

[0017] Further, an end of the material receiving opening where the material supporting member is located is provided with an annular groove, a side of the annular groove facing the conveying mechanism is provided with a sealing member, and the opening end of the material supporting member extends into the annular groove and sealingly cooperates with the sealing member.

[0018] Further, the vacuum freeze-drying device further comprises a vacuum pump, a cold trap having a cooling cavity, an air outlet of the cooling cavity being in communication with the vacuum pump, and an air inlet of the cooling cavity being in communication with the freeze-drying chamber, and a compressor configured to supply a cooling medium to a refrigeration coil of the freeze-drying chamber and a refrigeration coil of the cold trap.

[0019] By applying the technical solution of this invention, compared with the problem of existing spray freeze-drying systems being difficult to scale up due to the limitation of feed flow rate, this application separates the spray freezing device and the vacuum freeze-drying device. That is, the spray freezing device is not in a vacuum environment. In this way, the feed flow rate is not affected by the vacuum force. The material support component, which has been pre-cooled in the freeze-drying chamber, is automatically moved to the material receiving port by the conveying device. The spray freezing device rapidly freezes the liquid atomized material by direct cooling with liquid nitrogen. The frozen material in the spray freezing chamber falls onto the material support component through the material receiving port. Then, the material support component with the frozen material is automatically moved to the freeze-drying chamber of the vacuum freeze-drying device by the conveying device. The above steps are repeated until all material support components in the freeze-drying chamber are filled with material. Then, the material support component in all material support components is vacuum freeze-dried by the freeze-drying chamber. In this way, the spray freezing method can not only improve the freezing efficiency, but also the freeze-drying chamber can freeze-dry multiple batches and layers of material at one time. The degree of automation is high, the drying time can be shortened, and the drying efficiency can be improved. This enables scale-up production and increases the production capacity of the spray freeze-drying system. Attached Figure Description

[0020] The accompanying drawings, which form part of this application, are used to provide a further understanding of the invention. The illustrative embodiments of the invention and their descriptions are used to explain the invention and do not constitute an undue limitation of the invention. In the drawings:

[0021] Figure 1 A schematic diagram of an embodiment of the spray freeze-drying system of the present invention is shown;

[0022] Figure 2 It shows Figure 1 Enlarged view of point A in the spray freeze-drying system;

[0023] Figure 3 It shows Figure 1 A schematic diagram of the conveying mechanism of a spray freeze-drying system;

[0024] Figure 4 It shows Figure 1 Enlarged view of section B of the spray freeze-drying system;

[0025] Figure 5 It shows Figure 1 A schematic diagram of the material transfer component of a spray freeze-drying system;

[0026] Figure 6 It shows Figure 5 A left view of one state of the material transfer component;

[0027] Figure 7 It shows Figure 5 A left view of another state of the material transfer component;

[0028] Figure 8 A schematic view of a material support of a spray freeze-drying system is shown in Figure 1

[0029] Figure 9 A left view of the material support of the spray freeze-drying system is shown in Figure 8

[0030] A cross-sectional view of the material support of the spray freeze-drying system is shown in Figure 10 Figure 8 A schematic view of a material after the experimental test of the present application is shown in

[0031] Figure 11

[0032] In the above drawings, the following reference signs apply:

[0033] 11, spray freeze chamber; 12, material receiving port; 121, annular groove; 122, sealing member; 21, freeze-drying chamber; 22, material support; 221, groove; 31, vacuum pump; 32, cold trap; 33, compressor; 50, carrying device; 51, carrying mechanism; 511, first support; 512, carrying part; 513, first lifting member; 514, first guide member; 515, first sliding member; 516, mounting member; 517, screwing member; 518, screw rod; 519, limiting member; 52, material moving mechanism; 521, second support; 522, second lifting member; 523, second guide member; 524, second sliding member; 53, conveying mechanism; 531, support frame; 532, first driving part; 533, first rolling member; 534, first conveying belt; 54, mounting seat; 55, driving member; 56, pushing member; 57, air-avoiding groove; 581, mounting frame; 582, moving surface; 583, telescopic member; 584, material moving part; 585, second driving part; 586, second rolling member; 587, second conveying belt; 71, downward liquid nitrogen injection port; 72, opposite liquid nitrogen injection port; 73, lower cavity temperature sensor; 74, upper cavity temperature sensor; 75, feed peristaltic pump; 76, two-fluid needle-through nozzle; 77, atomized liquid gas injection port; 78, needle-through gas injection port; 79, partition plate. DETAILED DESCRIPTION

[0034] It should be noted that the embodiments and features in the embodiments of the present application can be combined with each other without conflict. The present application will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0035] As Figures 1 to 10 ​​​As shown, the embodiment of the present application provides a spray freeze-drying system, comprising: a spray freezing device having a spray freezing chamber 11 and a material receiving port 12, the material receiving port 12 is located at the bottom of the spray freezing chamber 11 and communicates with the spray freezing chamber 11, and the material receiving port 12 is used to output the frozen material; a vacuum freeze-drying device, comprising a freeze-drying bin 21 and a plurality of material supporting members 22, the freeze-drying bin 21 has a freeze-drying chamber for vacuum freeze-drying of the material, and the plurality of material supporting members 22 are movably placed in the freeze-drying chamber; a conveying device 50 for conveying the material supporting members 22, so that any one of the plurality of material supporting members 22 has a first position located below the material receiving port 12 and a second position located in the freeze-drying chamber, and when the material supporting member 22 is in the first position, the side of the material supporting member 22 for supporting the material is in sealing cooperation with the material receiving port 12.

[0036] In the above technical solution, compared with the problem that the feed flow rate is limited in the spray freeze-drying system in the prior art, in the present application, the spray freezing device and the vacuum freeze-drying device are separately arranged, that is, the spray freezing device is not in a vacuum environment, so that the feed flow rate is not affected by the vacuum force, and the material supporting member 22 pre-cooled by the freeze-drying bin 21 is automatically moved to the material receiving port 12 by the conveying device 50, the spray freezing device rapidly freezes the liquid atomized material by a liquid nitrogen direct cooling method, the frozen material in the spray freezing chamber 11 falls to the material supporting member 22 through the material receiving port 12, and then the material supporting member 22 with the frozen material is automatically moved to the freeze-drying bin 21 of the vacuum freeze-drying device by the conveying device 50, the above steps are repeated until all the material supporting members 22 in the freeze-drying bin 21 have materials, and then the materials in all the material supporting members 22 are vacuum freeze-dried by the freeze-drying bin 21, so that the spray freeze-drying method can not only improve the freezing efficiency, but also the freeze-drying bin 21 can freeze and dry multiple batches of materials at one time, has high automation degree, can shorten the drying time, improve the drying efficiency, and thus can realize scale-up production to improve the production capacity of the spray freeze-drying system.

[0037] Further, the present application is completed through the processes of atomization, freezing, transfer and multi-layer vacuum freeze-drying, the system can combine the processes of spray freezing and vacuum freeze-drying, realize complete continuity and intelligence of the transfer, loading and unloading and drying processes, expand the overall production capacity and output of the spray freeze-drying equipment under the premise of shortening the drying time and improving the drying efficiency, and solve the problem that the existing spray freeze-drying system is always in the small-scale test stage and has low production capacity.

[0038] A spray freeze-drying system is disclosed in Chinese Patent Publication No. CN214172702U, which comprises a freeze-drying cavity, a first cold trap, a second cold trap, a first isolation valve, a second isolation valve, and an atomization feeding device. The first cold trap is installed on one side of the freeze-drying cavity through the first isolation valve, the second cold trap is installed on the other side of the freeze-drying cavity through the second isolation valve, and the atomization feeding device is arranged at the top of the freeze-drying cavity. The bottom of the freeze-drying cavity is provided with a discharge port, and the discharge port is provided with a discharge valve. The spray freeze-drying system has the advantages of being able to quickly and stably complete cold trap switching, being conducive to realizing uninterrupted drying, etc. However, the overall application is still relatively difficult, such as the freeze-drying cavity freezing the atomized liquid droplets through jacket wall temperature heat exchange, indirect heat exchange restricting capacity improvement; such as the transition cavity switching vacuum easily causing ice particles to collide and extrude the ice type skeleton, affecting the freeze-drying efficiency; and it is difficult to monitor the material freezing effect during the freezing process. In the present application, the atomized liquid droplets are frozen by direct spraying of liquid nitrogen, which has high freezing efficiency. In addition, the spray freezing device and the vacuum freeze-drying device are separately arranged, and the material after spray freezing falls onto the material supporting member 22 and is conveyed by the conveying device 50. In this process, the material freezing state can be effectively observed, and the operation is simple.

[0039] In the prior art, due to the limitation of drying principle, the production capacity of spray freeze-drying is relatively low. In addition, spray freeze-drying is difficult to be made continuous, automatic and integrated. Manual intervention is required during the loading and unloading processes, which greatly causes unnecessary labor waste and further increases the cost. In the present application, the material after spray freezing falls onto the material supporting member 22 and is conveyed by the conveying device 50, without the need for manual intervention. It can be made continuous, automatic and integrated, which greatly reduces unnecessary labor waste and further reduces the cost.

[0040] In some embodiments, the material supporting member 22 is a tray.

[0041] As Figures 1 to 7As shown, in the embodiment of the present application, the freeze-drying bin 21 has a placing opening in communication with the freeze-drying chamber, and the conveying device 50 comprises: a conveying mechanism 51 arranged correspondingly to the material receiving opening 12, the conveying mechanism 51 being located below the material receiving opening 12, the conveying mechanism 51 having a conveying part 512, the conveying part 512 being arranged in the first direction relative to the spray-freezing device and being liftable so as to enable the conveying part 512 to approach or move away from the material receiving opening 12; a material moving mechanism 52 located at the side of the placing opening of the freeze-drying bin 21, the material moving mechanism 52 having a material moving part 584 capable of putting back and taking out any one of the material supporting members 22 in the freeze-drying chamber; and a conveying mechanism 53 located between the conveying mechanism 51 and the material moving mechanism 52, the conveying mechanism 53 being used for conveying the material supporting member 22, the material supporting member 22 reciprocating between the first position and the second position through the conveying mechanism 51, the conveying mechanism 53 and the material moving mechanism 52, and the first direction being arranged at an angle with the conveying direction of the conveying mechanism 53.

[0042] In the above technical solution, after the material is frozen in the spray-freezing chamber 11 and falls into the material supporting member 22, the conveying mechanism 51 lifts the material supporting member 22 from the first position below the spray-freezing chamber 11 to a position in abutment with the conveying mechanism 53, and then the material supporting member 22 is conveyed by the conveying mechanism 53 to the position of the material moving mechanism 52, and the material moving mechanism 52 puts the material supporting member 22 into the freeze-drying chamber of the freeze-drying bin 21 for vacuum freeze-drying, so that, through the lifting of the conveying part 512 of the conveying mechanism 51 and the material moving part 584 of the material moving mechanism 52, the automatic transfer of the material supporting member 22 between the spray-freezing and the vacuum freeze-drying can be realized, and the smooth conveying of the material supporting member 22 between the conveying mechanism 51 and the material moving mechanism 52 is ensured, so that the continuity and the automation level of the material processing can be improved, the production can be scaled up, and the manual intervention can be reduced, thereby reducing the production cost.

[0043] As shown in the drawings, Figure 2 In the embodiment of the present application, the conveying mechanism 51 comprises: a first support 511; a conveying table forming the conveying part 512; a first lifting member 513 arranged on the first support 511, the first lifting member 513 having a first lifting end arranged liftable relative to the first support 511, and the conveying table being connected to the first lifting end; and a first guide member comprising a first guide piece 514 arranged on the first support 511 and a first sliding piece 515, one end of the first sliding piece 515 being connected to the conveying table, and the other end of the first sliding piece 515 being in sliding fit with the first guide piece 514.

[0044] In the above technical solution, the first lifting component 513 drives the conveying part 512 to rise or fall, and the first guiding component can ensure that the conveying part 512 moves smoothly along the first direction so that the conveying part 512 can rise to the position of the material receiving port 12, or the conveying part 512 can fall to the position of docking with the conveying mechanism 53, so as to realize the transfer of the material support 22 between the conveying mechanism 53 and the material receiving port 12.

[0045] In some embodiments, the first lifting member 513 is a cylinder.

[0046] like Figure 3 As shown in the embodiment of the present invention, the conveying mechanism 51 further includes two clamping members. The two clamping members are arranged at intervals along the second direction. The first direction, the second direction and the conveying direction of the conveying mechanism 53 are arranged at angles to each other. The clamping members include a mounting member 516, a screwing member 517, a screw 518 and a limiting member 519. The mounting member 516 is connected to the conveying part 512. The screw 518 passes through the mounting member 516 and is threadedly engaged with the mounting member 516. One end of the screw 518 is connected to the screwing member 517, and the other end of the screw 518 is rotatably connected to the limiting member 519. The two limiting members 519 are arranged facing each other and form a limiting space for limiting the material support member 22.

[0047] In the above technical solution, the material support 22 moves onto the conveying part 512. By adjusting the screw 518 through the screwing part 517, the two limiting parts 519 move towards each other, forming a limiting space that matches the outer edge of the material support 22. This effectively limits the material support 22 during the conveying process, ensuring its stability. In this way, through the limiting effect of the clamping components, it is ensured that the material support 22 will not shift or shake during the conveying process, which not only improves the safety and efficiency of the conveying process, but also reduces material loss.

[0048] It should be noted that, as Figure 1 As shown, the first direction, the second direction, and the conveying direction of the conveying mechanism 53 are arranged perpendicularly to each other, with the second direction perpendicular to the direction of the conveying mechanism 53. Figure 1 The paper in question.

[0049] like Figure 1 and Figure 3 As shown, in an embodiment of the present invention, the conveying mechanism 51 further includes a pushing member, which includes: a mounting base 54 disposed on the conveying part 512, the mounting base 54 being located on the side of the limiting space away from the conveying mechanism 53; a driving member 55 disposed on the mounting base 54, the driving member 55 having a driving end movably disposed relative to the mounting base 54 in the conveying direction; and a pushing member 56 connected to the driving end, the pushing member 56 being able to extend into or out of the limiting space.

[0050] In the technical solution, the limiting piece 519 limits the material supporting piece 22, the driving piece 55 can drive the pushing piece 56 to extend into the limiting space, and the material supporting piece 22 is stably pushed onto the conveying mechanism 53, and the automatic transfer of the material supporting piece 22 is completed. In this way, the pushing effect of the pushing member can be used to stably push the material supporting piece 22 out of the limiting space onto the conveying mechanism 53, the accurate transfer of the material supporting piece 22 is ensured, the transfer efficiency and precision of the material supporting piece 22 are improved, manual operation is reduced, and production cost is reduced.

[0051] In some embodiments, the driving piece 55 is a pneumatic cylinder.

[0052] As shown in Figure 2 and Figure 3 In the embodiment of the present application, the side of the carrying part 512 facing the material receiving port 12 is provided with an empty slot 57, the projection area of the material supporting piece 22 on the carrying part 512 is larger than the area of the empty slot 57, and the empty slot 57 is in the projection area. In this way, after the tray is lifted to the position abutting against the material receiving port 12, the force is transmitted from the outer edge of the tray to prevent the deformation of the bottom surface of the tray.

[0053] In some embodiments, the depth of the empty slot 57 is 3mm.

[0054] It should be noted that the carrying table with the functions of lifting, limiting and transporting can prevent the deformation of the tray. The lifting of the carrying table is realized by the pneumatic cylinder and the guide column, the manually-operated and arbitrarily-adjustable clamping member is arranged on the platform, the pneumatic cylinder is arranged on the left side of the platform, and after the material is received, the tray is transported onto the conveying mechanism 53 by controlling the pneumatic cylinder. Furthermore, the empty slot 57 is arranged in the center of the platform, which can prevent the deformation of the bottom of the tray when the tray is in interference contact with the material receiving port 12, and finally leads to the unevenness of the bottom of the tray and affects the drying.

[0055] As shown in Figure 1 In the embodiment of the present application, the conveying mechanism 53 comprises a support frame 531, a first driving part 532 arranged on the support frame 531, a plurality of first rolling members 533 rotatably arranged on the support frame 531, the plurality of first rolling members 533 being arranged in sequence in the conveying direction, and the first driving part 532 being used for driving the plurality of first rolling members 533 to rotate. The first conveying belt 534 is located outside the plurality of first rolling members 533, and the first conveying belt 534 is used for conveying the material supporting piece 22.

[0056] In the above technical solution, the conveying unit 512 or the transfer unit 584 smoothly places the material support 22 on the first conveyor belt 534, causing the first drive unit 532 to rotate in both directions, driving multiple first rolling elements 533 to rotate, and driving the first conveyor belt 534 to transport the material support 22 between the transfer mechanism 52 and the conveying mechanism 51, thus completing the automated transfer of the material support 22. In this way, continuous and automated transfer of materials between different processing stages can be ensured, improving the efficiency and automation level of material transfer, reducing manual operation, and lowering production costs.

[0057] In some embodiments, the first rolling element 533 is a pulley, the first conveyor belt 534 is a belt, and the first drive unit 532 includes a plurality of motors, the output shafts of the plurality of motors being drivenly connected to the plurality of first rolling elements 533 respectively; or, the first drive unit 532 is a single motor, the output shaft of the single motor being drivenly connected to one of the plurality of first rolling elements 533, and the remaining first rolling elements 533 among the plurality of first rolling elements 533 are all driven wheels.

[0058] like Figure 1 , Figure 4 and Figure 5 As shown, in an embodiment of the present invention, the material transfer mechanism 52 includes: a second support 521 located below the freeze-drying chamber 21; a material transfer component having a material transfer portion 584; a second lifting component 522 disposed on the second support 521, the second lifting component 522 having a second lifting end that is vertically and vertically disposed relative to the second support 521 along a first direction, the material transfer component being connected to the second lifting end; and a second guide component including a second guide member 523 and a second sliding member 524, the second guide member 523 being disposed on the second support 521, one end of the second sliding member 524 being connected to the material transfer component, and the other end of the second sliding member 524 being slidably engaged with the second guide member 523.

[0059] In the above technical solution, the second lifting component 522 of the transfer mechanism 52 can drive the transfer part 584 to move until it is aligned with the material support 22 on the first conveyor belt 534. After the first conveyor belt 534 uses inertia to transport the material support 22 onto the transfer component, the second lifting component 522 can drive the transfer component to rise. Subsequently, the transfer part 584 accurately moves the material support 22 into the freeze-drying chamber of the freeze-drying chamber 21. The second guide component can ensure that the transfer component moves smoothly along the first direction. In this way, the lifting function of the second lifting component 522 and the guiding function of the second guide component can be used to ensure that the transfer component can accurately move the material support 22 to the second position while maintaining the stability of the material. This improves the accuracy and automation level of material transfer, reduces manual operation, and lowers production costs.

[0060] In some embodiments, the second lifting member 522 is a cylinder.

[0061] It should be noted that the first conveying belt 534 can use inertia to convey the material supporting member 22 to the material moving member or the carrying part 512.

[0062] As shown in Figure 1 , Figure 4 and Figures 5 to 9 , in the embodiment of the present application, the material supporting member 22 is provided with a groove 221, and the material moving member comprises: a mounting frame 581 connected with the second lifting end; a moving platform provided on the mounting frame 581, the moving platform having a moving surface 582 moving the material supporting member 22 in the conveying direction; an extension member 583 provided on the mounting frame 581, the extension member 583 having an extension end movably arranged in the second direction relative to the moving platform; a material moving member connected with the extension end, the material moving member cooperating with the groove 221 to enable the material supporting member 22 to be pulled from the freeze-drying chamber to the moving surface 582, the material moving member forming a material moving part 584.

[0063] In the above technical solution, the extension member 583 of the material moving member drives the material moving member to extend into the groove 221 on the material supporting member 22, and then the material moving member smoothly pulls the material supporting member 22 in the freeze-drying chamber to the moving surface 582, and the material supporting member 22 in the freeze-drying chamber is transferred to the moving surface 582 and then conveyed to the carrying part 512 by the moving surface 582; similarly, the first conveying belt 534 conveys the material supporting member 22 to the moving surface 582, and the extension member 583 of the material moving member drives the material moving member to push the material supporting member 22 into the freeze-drying chamber 21 for vacuum freeze-drying, so that by cooperating the material moving member with the groove 221 on the material supporting member 22 and using the extension function of the extension member 583, the material supporting member 22 can be smoothly pulled to the moving surface, and the material supporting member 22 can also be pushed into the freeze-drying chamber 21, which can ensure the automatic transfer of the material between different processing stages, improve the efficiency and automation level of the material transfer, reduce manual operation, and reduce production cost.

[0064] In some embodiments, the extension member 583 is a pneumatic cylinder.

[0065] It should be noted that by controlling the movement of the moving platform in the first direction and the movement of the material moving member in the second direction, the material moving member can be extended into the groove 221 on the material supporting member 22.

[0066] As shown in Figure 1 , Figure 4 and Figures 5 to 9As shown, in the embodiment of the present application, the transfer platform comprises: a second driving part 585 arranged on the mounting frame 581; a plurality of second rolling members 586 rotatably arranged on the mounting frame 581, the plurality of second rolling members 586 are arranged in sequence along the conveying direction, and the second driving part 585 is used for driving the plurality of second rolling members 586 to rotate; and a second conveying belt 587 located at the outer periphery of the plurality of second rolling members 586, and the upward side of the second conveying belt 587 forms the transfer surface 582.

[0067] In the above technical solution, the first conveying belt 534 conveys the material supporting member 22 to the second conveying belt 587, the second driving part 585 is reversed, the plurality of second rolling members 586 are driven to rotate, the second conveying belt 587 conveys the material supporting member 22, and the automatic transfer of the material supporting member 22 is completed. In this way, the second rolling members 586 can be driven to rotate by the second driving part 585, the second conveying belt 587 can stably transfer the material supporting member 22, the continuous and automatic transfer of the material between different processing stages is ensured, the efficiency and automation level of the material transfer are improved, manual operation is reduced, and the production cost is reduced.

[0068] In some embodiments, the second rolling member 586 is a pulley, the second conveying belt 587 is a belt, the second driving part 585 comprises a plurality of motors, and the output shafts of the plurality of motors are respectively drivingly connected to the plurality of second rolling members 586. Alternatively, the second driving part 585 is one motor, the output shaft of the motor is drivingly connected to one of the plurality of second rolling members 586, and the remaining second rolling members 586 are driven wheels.

[0069] As shown in Figure 2 and Figure 10 As shown in the embodiment of the present application, the end of the material receiving port 12 is provided with an annular groove 121, the side of the annular groove 121 facing the handling mechanism 51 is provided with a sealing member 122, and the open end of the material supporting member 22 extends into the annular groove 121 and sealingly cooperates with the sealing member 122.

[0070] In the above technical solution, after the material is frozen, the open end of the material supporting member 22 extends into the annular groove 121 and sealingly cooperates with the sealing member 122. Through the arrangement of the annular groove 121 and the sealing member 122, the material supporting member 22 is sealed when it is connected to the material receiving port 12 of the spray freezing device, air leakage during the material transfer process is prevented, and the vacuum condition of the drying process is ensured. In this way, the sealing performance and drying efficiency of the material transfer process are improved, and the loss and pollution of the material during the transfer process are reduced.

[0071] In some embodiments, the material supporting member 22 is a tray, as shown in Figures 8 to 10As shown, when the pallet contacts the seal 122 of the annular groove 121, its flanged structure can largely ensure the sealing performance between the pallet and the seal 122. In addition, the groove 221 on the outside of the pallet can play a role in stabilizing the translation during the automatic feeding and discharging stage. The second conveyor belt 587 of the transfer platform is controlled to transport the material. The second conveyor belt 587 is equipped with a material transfer component controlled by the telescopic component 583. During the process of taking out / placing the pallet, the material transfer component cooperates with the specially structured pallet. The automatic feeding and discharging purpose is achieved by adjusting the length of the telescopic component 583, the height of the second conveyor belt 587, and the height of the partition inside the freeze-drying chamber 21.

[0072] like Figure 1 As shown, in an embodiment of the present invention, the vacuum freeze-drying apparatus further includes: a vacuum pump 31; a cold trap 32 having a cooling chamber, the outlet of the cooling chamber being connected to the vacuum pump 31, and the inlet of the cooling chamber being connected to the freeze-drying chamber; and a compressor 33 for supplying cooling medium to the refrigeration coils of the freeze-drying chamber 21 and the refrigeration coils of the cold trap 32.

[0073] In the above technical solution, the vacuum pump 31 is activated to provide a high vacuum environment for the freeze-drying chamber, while the cooling chamber of the cold trap 32 provides low-temperature conditions. The compressor 33 provides a cooling medium for the refrigeration coil, ensuring that the material is dried efficiently under vacuum and low-temperature conditions, ultimately yielding high-quality dried material. Thus, by setting up the vacuum pump 31 and the cold trap 32, a high vacuum environment and low-temperature conditions are provided for the freeze-drying chamber of the freeze-drying chamber 21, and the compressor 33 provides a cooling medium for the refrigeration coil, ensuring the efficient execution of the freeze-drying process, improving the efficiency and quality of material drying, shortening the drying time, and reducing production costs.

[0074] It should be noted that, in addition to achieving equipment integration and automation, the spray freeze-drying system of the present invention can also increase the equipment capacity of spray freeze-drying, thereby achieving capacity expansion and improving drying efficiency and shortening drying time during the drying stage.

[0075] The actual production process of this application is as follows:

[0076] First, pre-cooling stage: open the compressor 33, pre-cooling the cold trap 32 and the tray in the freeze-drying chamber 21, the freeze-drying chamber 21 is provided with a plurality of layers of partitions 79 for supporting the tray, the partitions 79 are provided with serpentine refrigeration coils (refrigeration coils), the cold trap 32 and the refrigeration coils of the partitions 79 are connected with the compressor 33, the temperature of the cold trap coil needs to reach-80℃ or below, and the temperature of the refrigeration coil in the partition 79 needs to reach-50℃ or below. After reaching the two temperatures, the compressor 33 is always kept running until the end of drying, and the cold trap temperature is maintained at-80℃ during the process, and the temperature of the partition 79 is adjusted in real time according to different freeze-drying programs. During the pre-cooling stage, the tray is placed above the partition 79 of the freeze-drying chamber for pre-cooling.

[0077] Second, tray transfer stage: when the temperature of the tray on the partition 79 drops to-50℃, it needs to be transported to the lower part of the spray-freezing chamber 11 by the conveying device 50. The specific operation steps are as follows: by adjusting the second lifting member 522, the speed of the transfer platform rising and falling is controlled, the tray is taken out in order from top to bottom, starting from the top layer, when the transfer platform rises to the corresponding position, the telescopic member 583 is controlled, the telescopic member 583 controls the forward and backward movement of the material moving member, in addition, the inside of the freeze-drying chamber 21 is also provided with a lifting structure (which can adopt the existing technology, and will not be described here), which can make the partition 79 move up and down by controlling the lifting structure, so that the material moving member on the telescopic member 583 is clamped into the groove 221, after the tray is pulled into position on the second conveying belt 587 by the material moving member, the height of the transfer platform is adjusted to be level with the conveying mechanism 53, then the tray is conveyed to the conveying mechanism 53, and finally the tray is conveyed to the lifting conveying table by the conveying mechanism 53, the two clamping members can adjust the limiting space manually, after the tray is conveyed to the lifting conveying table, the whole lifting conveying table is controlled to rise by the first lifting member 513, when the outer edge of the tray rises to the sealing end face of the material receiving port 12, the lifting force of the first lifting member 513 is increased, so that the open end of the tray is tightly combined with the sealing end of the material receiving port 12, wherein the sealing member 122 is made of PTFE material which is resistant to low temperature, the structure of the outer edge of the tray is as shown in Figure 10 , which can ensure the sealing of the process, and the tray moving stage is completed.

[0078] Third, atomization freezing stage: open downward jet liquid nitrogen inlet 71 (can use the prior art, not described here) and the low temperature solenoid valve on the spray liquid nitrogen inlet 72, open the liquid nitrogen with 1.5 MPa dewar tank switch, liquid nitrogen into the spray freezing chamber, the temperature in the cavity begins to cool, in the process by observing the lower cavity temperature sensor 73 and the upper cavity temperature sensor 74 temperature change to adjust the two kinds of liquid nitrogen nozzle on the low temperature solenoid valve switch, if in the actual operation process, the lower cavity temperature is too low and the upper cavity temperature is too high, the low temperature solenoid valve on the pipeline of downward jet liquid nitrogen inlet 71 needs to be closed, and the low temperature solenoid valve on the pipeline of spray liquid nitrogen inlet 72 (can use the prior art, not described here) is kept open, if otherwise, the low temperature solenoid valve on the pipeline of downward jet liquid nitrogen inlet 71 is opened, and the low temperature solenoid valve on the pipeline of spray liquid nitrogen inlet 72 is closed, when the upper and lower cavity temperatures are lower than the eutectic point of the material to be frozen 30 ℃, the feeding and atomization operation can be carried out. The material liquid is delivered to the two-fluid needle nozzle 76 (can use the prior art, not described here) by the feeding peristaltic pump 75, the gas source is provided by the nitrogen tank, the atomization liquid gas inlet 77 and the needle gas inlet 78 (can use the prior art, not described here) on the two-fluid needle nozzle 76 are connected with the nitrogen tank respectively, and the electromagnetic valve is arranged on the pipeline. The atomization liquid gas inlet 77 (can use the prior art, not described here) is responsible for atomization liquid, and the needle gas inlet 78 controls the piston movement of the needle in the two-fluid needle nozzle 76 by opening and closing the electromagnetic valve on the pipeline, so as to prevent the nozzle from being blocked due to freezing of the material liquid at low temperature. The atomized fine particles are frozen into 'ice particles' after being contacted with the low-temperature environment, and the completely frozen ice particles fall into the pre-cooled tray below the cavity by gravity, the feeding peristaltic pump 75 is closed after spraying to the required amount, the low-temperature electromagnetic valve on the liquid nitrogen pipeline is stopped, and the atomization freezing stage is ended.

[0079] Fourth, transfer material stage: control the carrying table through the first lifting member 513 to separate the tray containing the material from the spray freezing chamber 11, and then lower the whole platform to the same horizontal plane as the conveying mechanism 53, open the pushing member to push the tray onto the conveying mechanism 53, the conveying mechanism 53 controls the conveying through the motor, and then the tray is conveyed to the transfer platform, and then the whole platform is raised through the second lifting member 522, and then the tray is pushed into the freeze-drying bin 21 through the material transferring member after the whole platform is raised to the original position.

[0080] Then, the tray in the freeze-drying bin 21 repeats the first, second, third and fourth processes until the material filling of all the trays is completed, and then the vacuum freeze-drying stage is entered.

[0081] Fifth, vacuum freeze-drying stage: after all the trays are filled, the door of the freeze-drying chamber 21 is automatically closed, the vacuum pump 31 starts to operate, the compressor 33 controls the temperature of the cold trap 32 and the baffle 79, and the temperature of the baffle 79 is set according to the properties of the material. Since the state of the material in the freeze-drying chamber 21 is granular / spherical, it has a very high specific surface area (the surface area per unit mass of material), and the sublimation process occurs on the surface of ice crystals. A larger specific surface area means that more ice surfaces are exposed to the vacuum to absorb heat and sublimate into water vapor in the same time. In addition, the voids between the particles provide a direct, low-resistance escape channel for the water vapor generated by sublimation. Water vapor can very smoothly leave the surface of the particles and enter the vacuum system, so the present application can not only shorten the drying time compared with traditional freeze-drying equipment, but also greatly expand the production capacity.

[0082] Sixth, material collection stage: after drying, the freeze-drying chamber 21 is depressurized, the second lifting member 522 and the baffle 79 of the freeze-drying chamber 21 are controlled, the trays are removed, and the removal process is the same as the tray transfer stage in the second step. After removal, the trays are transported to the material collection area on the right side of the freeze-drying chamber 21 by the second conveyor belt 587 for material collection, and the entire process is completed.

[0083] The biggest problem with existing spray freeze-drying equipment is that the production capacity is too low, the scale-up benefit is low, and it is difficult for enterprises to invest in production-level production. Moreover, spray freeze-drying equipment has been in the stage of small-scale experimental equipment and has developed slowly. The main problem that can be solved by the present patent is to expand the production capacity of spray freeze-drying equipment to hundreds of kilograms or even tons while retaining the spray freeze-drying process. The entire operation process of the present patent can be fully automated, continuous, and intelligent through the control of PLC automatic program. Existing spray freeze-drying equipment is almost manual or even semi-automatic operation, and the present patent can solve the problem of automatic production of spray freeze-drying equipment. As shown in the figure, it has been tested through preliminary experiments, and the overall drying time can be shortened by at least 40% compared with traditional freeze-drying. The overall material dispersion is good, and the flowability is good. The overall production capacity can be expanded to 200 kg per batch. Figure 11

[0084] ​From the above description, it can be seen that the above-mentioned embodiments of the present application achieve the following technical effects: compared with the problem that the spray freeze-drying system in the prior art is difficult to scale up production due to the limitation of the feed flow rate, in the present application, the spray freezing device and the vacuum freeze-drying device are separately arranged, that is, the spray freezing device is not in a vacuum environment, so that the feed flow rate is not affected by the vacuum force, and the material support pre-cooled in the freeze-drying bin is automatically moved to the material receiving port by the carrying device, the spray freezing device rapidly freezes the liquid atomized material by the liquid nitrogen direct cooling method, the frozen material in the spray freezing chamber falls to the material support through the material receiving port, and then the material support with the frozen material is automatically moved to the freeze-drying bin of the vacuum freeze-drying device by the carrying device, the above steps are repeated until all the material supports in the freeze-drying bin have materials, and then the materials in all the material supports are vacuum freeze-dried by the freeze-drying bin, so that the spray freezing method can not only improve the freezing efficiency, but also the freeze-drying bin can freeze and dry multiple batches of materials in multiple layers at one time, the degree of automation is high, the drying time can be shortened, the drying efficiency can be improved, and therefore the production can be scaled up, so that the production capacity of the spray freeze-drying system can be improved.

[0085] The above merely describes the preferred embodiments of the present application and is not intended to limit the present application. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A spray freeze-drying system characterized in that, The application relates to a spray-freezing device, a vacuum freeze-drying device, and a conveying device. The spray-freezing device comprises a spray-freezing chamber (11) and a material receiving port (12) located at the bottom of the spray-freezing chamber (11) and communicating with the spray-freezing chamber (11), the material receiving port (12) being used for outputting frozen materials. The vacuum freeze-drying device comprises a freeze-drying chamber (21) and a plurality of material supporting members (22), the freeze-drying chamber (21) having a freeze-drying chamber for vacuum freeze-drying of materials, and the plurality of material supporting members (22) being movably placed in the freeze-drying chamber. The conveying device (50) is used for conveying the material supporting members (22), so that any one of the plurality of material supporting members (22) has a first position located below the material receiving port (12) and a second position located in the freeze-drying chamber, and when the material supporting member (22) is in the first position, the side of the material supporting member (22) for supporting materials is in sealing cooperation with the material receiving port (12). The freeze-drying chamber (21) has a placing port communicating with the freeze-drying chamber, and the conveying device (50) comprises: a conveying mechanism (51) corresponding to the material receiving port (12), the conveying mechanism (51) being located below the material receiving port (12), the conveying mechanism (51) having a conveying part (512) which is movably arranged in a first direction relative to the spray-freezing device, so that the conveying part (512) can be close to or away from the material receiving port (12); a material moving mechanism (52) located at the side of the placing port of the freeze-drying chamber (21), the material moving mechanism (52) having a material moving part (584) which can place and take out any one of the material supporting members (22) in the freeze-drying chamber; a conveying mechanism (53) located between the conveying mechanism (51) and the material moving mechanism (52), the conveying mechanism (53) being used for conveying the material supporting members (22), the material supporting members (22) reciprocating between the first position and the second position through the conveying mechanism (51), the conveying mechanism (53) and the material moving mechanism (52), the first direction being arranged at an angle with the conveying direction of the conveying mechanism (53); a material moving member having the material moving part (584); the material moving mechanism (52) comprises a second lifting member (522) having a second lifting end which is movably arranged in the first direction; the material supporting member (22) is provided with a groove (221), and the material moving member comprises: a mounting frame (581) connected with the second lifting end; a material transferring platform provided on the mounting frame (581), the material transferring platform having a material transferring surface (582) for transferring the material supporting members (22) in the conveying direction; and a material transferring mechanism provided on the material transferring surface (582), the material transferring mechanism comprising a plurality of material transferring members (583) arranged in the conveying direction, the material transferring members (583) being used for transferring the material supporting members (22) in the conveying direction. A telescopic member (583) is arranged on the mounting frame (581), and the telescopic member (583) has a telescopic end arranged to be movable relative to the transfer platform along a second direction; A material moving member is connected with the telescopic end, and the material moving member is matched with the groove (221) to enable the material supporting member (22) to be pulled from the freeze-drying chamber to the transfer surface (582), and the material moving member forms the material moving part (584).

2. The spray freeze-drying system of claim 1, wherein, The carrying mechanism (51) comprises: a first support (511); a carrying table, which forms the carrying part (512); a first lifting member (513) arranged on the first support (511), the first lifting member (513) having a first lifting end arranged to be liftable relative to the first support (511) along the first direction, and the carrying table being connected to the first lifting end; a first guide member comprising a first guide piece (514) arranged on the first support (511) and a first sliding piece (515) having one end connected to the carrying table and the other end slidingly matched with the first guide piece (514).

3. The spray freeze-drying system of claim 1, wherein, The carrying mechanism (51) further comprises two clamping members arranged in a spaced manner along a second direction, the first direction, the second direction and the conveying direction of the conveying mechanism (53) being arranged at an included angle with each other, and the clamping member comprising a mounting piece (516), a screwing piece (517), a screw rod (518) and a limiting piece (519), the mounting piece (516) being connected to the carrying part (512), the screw rod (518) being arranged through the mounting piece (516) and being threadedly matched with the mounting piece (516), one end of the screw rod (518) being connected to the screwing piece (517), and the other end of the screw rod (518) being rotationally connected to the limiting piece (519), the two limiting pieces (519) being arranged opposite to each other and forming a limiting space for limiting the material supporting member (22).

4. The spray freeze-drying system of claim 3, wherein, The carrying mechanism (51) further comprises a pushing member, which comprises: a mounting seat (54) arranged on the carrying part (512), the mounting seat (54) being located on a side of the limiting space away from the conveying mechanism (53); a driving piece (55) arranged on the mounting seat (54), the driving piece (55) having a driving end arranged to be movable relative to the mounting seat (54) along the conveying direction; a pushing piece (56) connected with the driving end, the pushing piece (56) being capable of extending into or out of the limiting space.

5. The spray freeze-drying system of claim 1, wherein, A void slot (57) is arranged on a side of the carrying part (512) facing the material receiving port (12), the projection area of the material supporting member (22) on the carrying part (512) is greater than the area of the void slot (57), and the void slot (57) is located in the projection area.

6. The spray freeze-drying system according to any one of claims 1 to 5, wherein, The conveying mechanism (53) comprises: a support frame (531); A first driving part (532) is arranged on the support frame (531); A plurality of first rolling members (533) are rotatably arranged on the support frame (531), and the first rolling members (533) are arranged in sequence along the conveying direction, and the first driving part (532) is used for driving the first rolling members (533) to rotate; A first conveying belt (534) is arranged outside the first rolling members (533), and the first conveying belt (534) is used for conveying the material supporting member (22).

7. The spray freeze-drying system according to any one of claims 1 to 5, wherein, The material moving mechanism (52) comprises: A second support frame (521) is arranged below the freeze-drying chamber (21); A second lifting member (522) is arranged on the second support frame (521), and the second lifting member (522) has a second lifting end which is arranged to be liftable relative to the second support frame (521) along the first direction, and the material moving member is connected to the second lifting end; A second guide member comprises a second guide member (523) and a second sliding member (524), the second guide member (523) is arranged on the second support frame (521), one end of the second sliding member (524) is connected to the material moving member, and the other end of the second sliding member (524) is in sliding fit with the second guide member (523).

8. The spray freeze-drying system of claim 1, wherein, The material moving platform comprises: A second driving part (585) is arranged on the mounting frame (581); A plurality of second rolling members (586) are rotatably arranged on the mounting frame (581), and the second rolling members (586) are arranged in sequence along the conveying direction, and the second driving part (585) is used for driving the second rolling members (586) to rotate; A second conveying belt (587) is arranged outside the second rolling members (586), and an upward side of the second conveying belt (587) forms the material moving surface (582).

9. The spray freeze-drying system of any one of claims 1 to 5, wherein, An annular groove (121) is arranged on an end of the material receiving opening (12), a sealing member (122) is arranged on a side of the annular groove (121) facing the material moving mechanism (51), and an open end of the material supporting member (22) is inserted into the annular groove (121) and sealingly matched with the sealing member (122).

10. The spray freeze-drying system of any one of claims 1 to 5, wherein, The vacuum freeze-drying device further comprises: A vacuum pump (31); A cold trap (32) has a cooling cavity, an air outlet of the cooling cavity is communicated with the vacuum pump (31), and an air inlet of the cooling cavity is communicated with the freeze-drying chamber; A compressor (33) is used for supplying cooling medium to the refrigeration coil of the freeze-drying chamber (21) and the refrigeration coil of the cold trap (32).

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