Skin barrier repair composition with nano repair function

Abstract

The invention relates to the technical field of skin care and repair, in particular to a skin barrier repair composition containing nano repair, which comprises a nano-scale active component, a biocompatible high polymer material, a plant extract and a humectant. By optimizing the formula design and the preparation process, the composition can deeply permeate into the skin, promote barrier repair, reduce water loss, scavenge free radicals and improve the problems of dryness and sensitivity. The invention further provides a preparation method, a performance testing method and application of the polymer, and the polymer can be widely applied to the fields of cosmetics, biological medicine and medical instruments. Cost control and storage and transportation optimization measures are adopted, the production cost is remarkably reduced, and the stability is improved. The defects of component design, action depth and cost control in the prior art are overcome, and the method has remarkable technical advantages and market prospects.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of skin care and repair, specifically a skin barrier repair composition containing nanorepair. BACKGROUND

[0002] With the continuous development of skin repair technology, research on skin barrier function repair has gradually become an important direction in the fields of cosmetics, biological medicine and medical devices. However, the existing technology still has certain limitations in terms of ingredient design, mechanism of action and application effect, and cannot fully meet the needs of skin barrier repair.

[0003] After searching, a skin care and repair composition with publication number CN113599346B was found, which was published on March 8, 2024. This patent uses amniotic fluid and its extract as the main ingredient, which has the effects of delaying skin aging, preventing skin diseases, etc., and can promote skin repair to a certain extent. However, the mechanism of action of this technical solution is mainly based on the exogenous supplementation of macromolecular biological materials, and lacks the application of nanoscale repair ingredients, which may limit its precise repair effect on the deep layer of skin barrier function. In addition, the raw material source of this composition is special, which may increase the preparation cost and is not conducive to large-scale popularization and application.

[0004] After searching, a skin wound repair device with publication number CN115006708B was found, which was published on November 15, 2024. This patent improves the structure of the rubber tube and the composition of the adhesive to achieve controllable release of the adhesive flow rate on the skin wound, and promotes wound healing through the brushing method. However, this technical solution mainly relies on physical methods to apply adhesive to the wound, and does not deeply explore the overall repair effect of active ingredients in the adhesive on the skin barrier function. At the same time, its application range is limited to wound repair, and has limited effect on improving the skin barrier function, and the device design is complex and the operation steps are more, which may affect the user's experience.

[0005] The above problems show that the existing technology still has room for improvement in terms of ingredient design, depth of action, repair efficiency and cost control. Therefore, the present application provides a skin barrier repair composition containing nanorepair, which aims to introduce nanoscale active ingredients to optimize the repair effect of the composition on the skin barrier function, simplify the preparation process and reduce production costs, so as to better meet the market demand for efficient, convenient and economical skin barrier repair products. SUMMARY

[0006] The purpose of the present application is to provide a method for preparing a skin barrier repair composition containing nanorepair, comprising the following steps:

[0007] S10: dissolving the nanoscale active ingredient in a dispersant to prepare a uniform nanodispersion; the nanoscale active ingredient is at least one of nanoscale titanium dioxide, nanoscale zinc oxide, and nanoscale silver particles, the dispersant is polyvinyl alcohol or polyethylene glycol, and the mass fraction of the nanoscale active ingredient in the nanodispersion is 0.1% to 5%;

[0008] S20: adding a biocompatible polymer material to the nanodispersion, and stirring and mixing to obtain a premix; the biocompatible polymer material is at least one of sodium hyaluronate, chitosan, and sodium carboxymethyl cellulose, and the mass fraction of the biocompatible polymer material is 1% to 10%;

[0009] S30: adding a plant extract and a humectant to the premix, and continuing to stir until completely dissolved to obtain a mixture; the plant extract is at least one of aloe extract, calendula extract, and green tea extract, the mass fraction of the plant extract is 2% to 15%, and the humectant is glycerol or propylene glycol, and the mass fraction of the humectant is 5% to 20%;

[0010] S40: filtering and homogenizing the mixture, and then filling and sealing to obtain a skin barrier repair composition containing nanorepair.

[0011] Preferably, in step S10, the particle size of the nanoscale active ingredient ranges from 10 nm to 100 nm.

[0012] Preferably, in step S10, the molecular weight of the dispersant is 2000 to 20000.

[0013] Preferably, in step S20, the molecular weight of the biocompatible polymer material is 50000 to 1000000.

[0014] Preferably, in step S30, the extraction solvent of the plant extract is water or ethanol, the extraction temperature is 40°C to 60°C, and the extraction time is 2 hours to 6 hours.

[0015] Preferably, in step S40, the pressure of the homogenization is 20 MPa to 50 MPa, and the number of homogenization is 2 to 5 times.

[0016] Preferably, it is applied in the fields of cosmetics, biological medicine, or medical devices.

[0017] Preferably, when the skin barrier repair composition containing nanorepair is applied in the field of cosmetics, it is used as an active ingredient of a face cream, serum, or mask.

[0018] Preferably, the skin barrier repair composition containing nanorepair is applied in the field of biomedicine as an active ingredient of a skin repair dressing or ointment.

[0019] Compared with the prior art, the skin barrier repair composition containing nanorepair provided by the present application and the preparation method, application, performance test method, storage method, transportation method, and cost control method thereof have the following beneficial effects: by introducing nanoscale active ingredients and optimizing the formula design, the skin barrier repair composition containing nanorepair solves the problems of the prior art in terms of component design, depth of action, repair efficiency, and cost control, and has significant technical advantages and market prospects. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the present application are described clearly and completely. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0021] Embodiment 1: Preparation of a skin barrier repair composition containing nanorepair

[0022] S10: 2 g of nanometer titanium dioxide was dissolved in 100 mL of a 1% polyvinyl alcohol solution by mass fraction, and stirred at room temperature for 30 minutes using a magnetic stirrer until a uniform nanodispersion was formed. The particle size of the nanometer titanium dioxide was 50 to 80 nanometers, and the molecular weight of the polyvinyl alcohol was 10000. S20: 5 g of sodium hyaluronate was added to the above nanodispersion, and stirred at 500 rpm for 1 hour using a mechanical stirrer to obtain a premix. The molecular weight of the sodium hyaluronate was 500000. S30: 10 g of aloe extract and 15 g of glycerol were sequentially added to the premix, and continued to be stirred for 30 minutes until completely dissolved to obtain a mixture. The extraction solvent of the aloe extract was water, the extraction temperature was 50°C, and the extraction time was 4 hours. The amount of glycerol added was 10% of the volume of the mixture. S40: The mixture was filtered through a filter membrane with a pore size of 0.2 microns, then homogenized 3 times using a homogenizer under a pressure of 30 MPa, and finally filled and sealed to obtain a skin barrier repair composition containing nanorepair.

[0023] Embodiment 2: Preparation of a skin barrier repair composition containing nanorepair

[0024] S10: 3 g of nano-sized zinc oxide was dissolved in 100 mL of a 2% by mass polyethylene glycol solution, and dispersed at 30°C for 20 minutes using an ultrasonic disperser until a uniform nano-dispersion was formed. The nano-sized zinc oxide had a particle size range of 30 to 60 nm, and the polyethylene glycol had a molecular weight of 15,000. S20: 8 g of chitosan was added to the above nano-dispersion, and stirred at 600 rpm for 1.5 hours using a mechanical stirrer to obtain a premix. The chitosan had a molecular weight of 800,000. S30: 12 g of marigold extract and 20 g of propylene glycol were sequentially added to the premix, and stirred for 40 minutes until completely dissolved to obtain a mixture. The marigold extract was extracted using ethanol as an extraction solvent at 45°C for 5 hours. The propylene glycol was added in an amount of 15% by volume of the mixture. S40: The mixture was filtered through a filter membrane having a pore size of 0.45 μm, and then homogenized 4 times at a pressure of 40 MPa using a homogenizer, and finally filled and sealed to obtain a skin barrier repair composition containing nano-repair.

[0025] Example 3: Preparation of a skin barrier repair composition containing nano-repair

[0026] S10: 1.5 g of nano-sized silver particles was dissolved in 100 mL of a 0.5% by mass polyvinyl alcohol solution, and stirred at room temperature for 25 minutes using a magnetic stirrer until a uniform nano-dispersion was formed. The nano-sized silver particles had a particle size range of 20 to 50 nm, and the polyvinyl alcohol had a molecular weight of 5,000. S20: 6 g of sodium carboxymethyl cellulose was added to the above nano-dispersion, and stirred at 550 rpm for 1 hour using a mechanical stirrer to obtain a premix. The sodium carboxymethyl cellulose had a molecular weight of 700,000. S30: 15 g of green tea extract and 25 g of glycerol were sequentially added to the premix, and stirred for 35 minutes until completely dissolved to obtain a mixture. The green tea extract was extracted using water as an extraction solvent at 55°C for 3 hours. The glycerol was added in an amount of 20% by volume of the mixture. S40: The mixture was filtered through a filter membrane having a pore size of 0.22 μm, and then homogenized 5 times at a pressure of 50 MPa using a homogenizer, and finally filled and sealed to obtain a skin barrier repair composition containing nano-repair.

[0027] The skin barrier repair composition containing nano-repair prepared according to the above examples had the following composition:

[0028] Component Mass fraction (%) Example 1 Example 2 Example 3 Nanometer-sized active ingredient 0.1 to 5 2 3 1.5 Dispersant 1 to 10 1 2 0.5 Biocompatible polymer material 1 to 10 5 8 6 Plant extract 2 to 15 10 12 15 Moisturizer 5 to 20 15 20 25

[0029] Example 4: Application in the cosmetic field

[0030] The composition prepared in Example 1 was used as an active ingredient of a cream, and mixed with conventional emulsifiers, thickeners, and preservatives to prepare a cream product according to a conventional process.

[0031] Example 5: Application in the field of biological medicine

[0032] The composition prepared in Example 2 is mixed with conventional matrix materials as the active ingredient of a medicinal plaster, and is prepared into a skin repair dressing according to conventional process.

[0033] Example 6: Application in the field of medical devices

[0034] The composition prepared in Example 3 is coated as a coating material on the surface of a skin care device, and is cured according to conventional process.

[0035] Although the present application has been described in detail with reference to the foregoing embodiments, those skilled in the art can make modifications to the technical solutions recorded in the foregoing embodiments, or make equivalent replacements to part of the technical features, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present application shall be included in the protection scope of the present application.

Claims

1. A method for preparing a skin barrier repair composition containing nano-repair components, characterized in that, Includes the following steps: S10: Dissolve the nano-sized active ingredient in a dispersant to prepare a uniform nano-dispersion; the nano-sized active ingredient is at least one of nano-titanium dioxide, nano-zinc oxide, and nano-silver particles, the dispersant is polyvinyl alcohol or polyethylene glycol, and the mass fraction of the nano-sized active ingredient in the nano-dispersion is 0.1% to 5%; S20: Add a biocompatible polymer to the nano-dispersion, stir and mix to obtain a premix; the biocompatible polymer is at least one of sodium hyaluronate, chitosan, and sodium carboxymethyl cellulose, and the mass fraction of the biocompatible polymer is 1% to 10%; S30: Add plant extracts and a humectant to the premixed solution, and continue stirring until completely dissolved to obtain a mixture; the plant extract is at least one of aloe vera extract, calendula extract, and green tea extract, and the mass fraction of the plant extract is 2% to 15%; the humectant is glycerin or propylene glycol, and the mass fraction is 5% to 20%. S40: The mixture is filtered, homogenized, and then filled and sealed to obtain a skin barrier repair composition containing nano-repair.

2. The method according to claim 1, characterized in that, In step S10, the particle size range of the nanoscale active ingredient is 10 nanometers to 100 nanometers.

3. The method according to claim 1, characterized in that, In step S10, the molecular weight of the dispersant is between 2000 and 20000.

4. The method according to claim 1, characterized in that, In step S20, the molecular weight of the biocompatible polymer material is between 50,000 and 1,000,000.

5. The method according to claim 1, characterized in that, In step S30, the extraction solvent for the plant extract is water or ethanol, the extraction temperature is 40°C to 60°C, and the extraction time is 2 hours to 6 hours.

6. The method according to claim 1, characterized in that, In step S40, the pressure of the homogenization process is 20 MPa to 50 MPa, and the number of homogenization cycles is 2 to 5.

7. A skin barrier repair composition containing nano-repair, characterized in that, Prepared according to the method of any one of claims 1 to 6.

8. The application of a skin barrier repair composition containing nano-repair, characterized in that, It can be applied to the fields of cosmetics, biomedicine, or medical devices.

9. The application according to claim 8, characterized in that, When the skin barrier repair composition containing nano-repair is applied in the cosmetic field, it serves as an active ingredient in face creams, serums, or masks.

10. The application according to claim 8, characterized in that, When the nano-repair skin barrier repair composition is applied in the biomedical field, it serves as an active ingredient in skin repair dressings or ointments.