Preparation method of cough and asthma relieving granules

Abstract

The invention discloses a preparation method of cough and asthma relieving granules, and belongs to the field of traditional Chinese medicine preparation, and the preparation method comprises the following steps: S1, sealed extraction to obtain a mixed solution: performing pulse type ultrasonic treatment on folium rhododendri daurici in an ethanol water solution for 1-3 minutes, then extracting for 66-78 hours at the temperature of 30-40 DEG C, and intermittently stirring; s2, filtering and squeezing to obtain an extracting solution; s3, concentrating the extracting solution to obtain a clear paste with the relative density of 1.10-1.2 at the temperature of 70-80 DEG C; s4, adjusting the pH value to 3.5-5.5, and removing astringency; s5, filtering with an ultrafiltration membrane, concentrating to obtain clear paste with the relative density of 1.10-1.2 at 70-80 DEG C, and spray-drying the clear paste to obtain extract powder; and S6, adding auxiliary materials into the extract powder, mixing, adjusting, preparing granules, drying, finishing the granules, screening, totally mixing, and sub-packaging to obtain the cough and asthma relieving granules. The extraction time is shortened, and the product stability is improved.

Description

Technical Field

[0001] This invention relates to the preparation of traditional Chinese medicine, and in particular to a method for preparing cough and asthma granules. Background Technology

[0002] Xiaokechuan granules play an important role in the treatment of respiratory diseases such as acute and chronic bronchitis, colds, and coughs. It integrates the functions of "clearing the lungs, resolving phlegm, relieving cough, and relieving asthma" and can effectively alleviate core symptoms such as cough, excessive phlegm, and wheezing. Its importance is not only reflected in its definite clinical efficacy and wide application among the general public, but also in the fact that it represents the overall therapeutic advantage of traditional Chinese medicine in the respiratory field of "multi-component and multi-target", providing patients with a treatment option with relatively few side effects and effectiveness.

[0003] CN115177592A discloses a method for preparing cough and asthma granules and the product thereof. In the preparation method, the extraction solvent of rhododendron molle is an aqueous solution with a volume fraction of 40% ethanol, and the extraction temperature is 30~50℃ (the upper limit temperature is increased by 10℃ compared with the pharmacopoeia).

[0004] Although the cough and asthma granules disclosed in CN115177592A have good efficacy, they have certain shortcomings: (1) The soaking time is relatively long, requiring 7 days, which affects production efficiency. (2) The stability is relatively poor.

[0005] The above background information is provided to facilitate understanding of the present invention and is not intended to be publicly known technology disclosed to the general public prior to the application of this invention. Summary of the Invention

[0006] To address the aforementioned deficiencies, this invention provides a method for preparing cough and asthma granules, which aims to improve at least one of the problems mentioned in the background art.

[0007] The technical solution is: a method for preparing cough and asthma granules, comprising the following steps: S1. Closed extraction to obtain a mixture: Rhododendron molle was first subjected to pulsed sonication in an ethanol-water solution for 1 min to 3 min, and then extracted for 66 h to 78 h at a temperature of 30℃ to 40℃, with intermittent stirring during the extraction process; S2. Filter the mixture obtained in S1 to obtain filtrate and filter residue. Press the filter residue and filter the extract to obtain pressed filtrate. Combine the filtrate and pressed filtrate to obtain extract. S3. Concentrate the extract to a clear paste with a relative density of 1.10 to 1.2 at 70℃ to 80℃; S4. Add a pH adjuster to the ointment to adjust the pH to 3.5~5.5, and add the astringent solution while stirring to remove astringency; S5. Ultrafiltration membrane filtration, concentrating the ultrafiltration filtrate to obtain a clear extract with a relative density of 1.10~1.2 at 70℃~80℃, and spray drying the clear extract to obtain an extract powder; S6. Mix the extract powder with excipients, prepare granules, dry, granulate, sieve, mix, and package to obtain cough and asthma granules.

[0008] Furthermore, in S1, the pulsed ultrasound has a frequency of 20kHz~40kHz, a power of 90W / cm²~110W / cm², an amplitude of 45~55%, and a pulse period of 2 seconds on and 3 seconds off.

[0009] Furthermore, in S1, the intermittent stirring is started once on the evening of the first day, with a stirring time of 8 to 12 minutes. From the second day onwards, the stirring is started once each in the morning and evening, with a stirring time of 8 to 12 minutes. The stirring speed for each stirring is 170 to 190 rpm.

[0010] Furthermore, in S1, the volume of the ethanol-water solution is 4500 ml to 5500 ml of ethanol-water solution per 1000 g of *Rhododendron molle*, and the ethanol-water solution is 30% v / v to 50% v / v ethanol-water solution.

[0011] Furthermore, in S1, the size of the rhododendron is 2mm~5mm.

[0012] Furthermore, in S4, the pH adjuster is lactic acid, and the deastringency-removing aqueous solution is a chitosan aqueous solution.

[0013] Further, the chitosan aqueous solution is a chitosan aqueous solution of 1.5 wt% to 2.5 wt%, and the amount of chitosan aqueous solution is 2.8 to 3.3 times the amount of the extract obtained in S3.

[0014] Furthermore, in S4, the pH is 4.5.

[0015] Compared with the prior art, the beneficial effects of the present invention are as follows: This invention utilizes a combination of short-pulse extraction, immersion, and intermittent stirring to shorten the extraction time and improve product stability while maintaining the efficacy of freshly prepared cough and asthma granules. Furthermore, by selecting rhododendron simsii as the raw material, using rhododendron simsii with a diameter of 2mm to 5mm, this invention further enhances product stability while preserving the efficacy of freshly prepared cough and asthma granules.

[0016] This invention also eliminates the astringency of the product by combining chitosan, lactic acid, and a specific pH range, resulting in better palatability. Detailed Implementation

[0017] As used in this article: "Prepared from" is synonymous with "comprising". The terms "comprising", "including", "having", "containing", or any other variations thereof as used herein are intended to cover non-exclusive inclusion. For example, a composition, step, method, article, or apparatus that includes the listed elements is not necessarily limited to those elements, but may include other elements not expressly listed or elements inherent to such composition, step, method, article, or apparatus.

[0018] When a quantity, concentration, or other value or parameter is expressed as a range, a preferred range, or a range defined by a series of upper and lower preferred values, this should be understood as specifically disclosing all ranges formed by any pair of any upper or preferred value with any lower or preferred value, regardless of whether the range is disclosed individually. For example, when the range “1–5” is disclosed, the described range should be interpreted as including ranges “1–4”, “1–3”, “1–2”, “1–2 and 4–5”, “1–3 and 5”, etc. When numerical ranges are described herein, unless otherwise stated, the range is intended to include its endpoints and all integers and fractions within that range.

[0019] The technical solution of the present invention will be clearly and completely described below with reference to the embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0020] Those skilled in the art will understand that the following embodiments are for illustrative purposes only and should not be construed as limiting the scope of this application. Where specific conditions are not specified in the embodiments, conventional conditions or conditions recommended by the manufacturer shall apply. Reagents or instruments whose manufacturers are not specified are all commercially available conventional products.

[0021] In these embodiments, unless otherwise specified, the portions and percentages are all by weight.

[0022] "Parts by mass" refers to the basic unit of measurement that expresses the mass ratio of multiple components. One part can represent any unit mass, such as 1g or 2.689g. If we say that component A has "a" parts by mass and component B has "b" parts by mass, it means the ratio of the mass of component A to the mass of component B is a:b. Alternatively, it can mean that the mass of component A is aK and the mass of component B is bK (K is any number representing a multiplier). It is important to understand that, unlike the number of parts by mass, the sum of the mass parts of all components is not limited to 100 parts.

[0023] "And / or" is used to indicate that one or both of the described situations may occur, for example, A and / or B includes (A and B) and (A or B).

[0024] A method for preparing cough and asthma granules includes the following steps: S1. Closed extraction to obtain a mixture: Rhododendron molle was first subjected to pulsed sonication in an ethanol-water solution for 1 min to 3 min, and then extracted for 66 h to 78 h at a temperature of 30℃ to 40℃, with intermittent stirring during the extraction process; S2. Filter the mixture obtained in S1 to obtain filtrate and filter residue. Press the filter residue and filter the extract to obtain pressed filtrate. Combine the filtrate and pressed filtrate to obtain extract. S3. Concentrate the extract to a clear paste with a relative density of 1.10 to 1.2 at 70℃ to 80℃; S4. Add a pH adjuster to the ointment to adjust the pH to 3.5~5.5, and add the astringent solution while stirring to remove astringency; S5. Ultrafiltration membrane filtration, concentrating the ultrafiltration filtrate to obtain a clear extract with a relative density of 1.10~1.2 at 70℃~80℃, and spray drying the clear extract to obtain an extract powder; S6. Mix the extract powder with excipients, prepare granules, dry, granulate, sieve, mix, and package to obtain cough and asthma granules.

[0025] Preferably, in S1, the pulsed ultrasound has a frequency of 20kHz~40kHz, a power of 90 W / cm²~110 W / cm², an amplitude of 45~55%, and a pulse period of 2 seconds on and 3 seconds off.

[0026] As a preferred embodiment, in S1, the intermittent stirring is started once on the evening of the first day, with a stirring time of 8 to 12 minutes. From the second day onwards, the stirring is started once each in the morning and evening, with a stirring time of 8 to 12 minutes. The stirring speed for each stirring is 170 to 190 rpm.

[0027] Preferably, in S1, the amount of ethanol-water solution is 4500ml~5500ml of ethanol-water solution per 1000g of *Rhododendron molle*, and the ethanol-water solution is 30%v / v~50%v / v ethanol-water solution.

[0028] As a preferred option, in S1, the size of the rhododendron is 2mm~5mm.

[0029] Preferably, in S4, the pH adjuster is lactic acid, and the deastringent aqueous solution is a chitosan aqueous solution.

[0030] Preferably, the chitosan aqueous solution is a chitosan aqueous solution of 1.5 wt% to 2.5 wt%, and the amount of chitosan aqueous solution is 2.8 to 3.3 times the amount of the extract obtained in S3.

[0031] Preferably, in S4, the pH is 4.5.

[0032] In the following examples and comparative examples, Rhododendron molle I, Rhododendron molle II, and Rhododendron molle III were prepared by the following method: (This method is a conventional method for preparing raw materials in the field of traditional Chinese medicine) Preparation of Rhododendron molle: After cleaning, selecting and drying the Rhododendron molle purchased from the market, crush and sieve it to obtain particles (or initial powder) of about 1 mm.

[0033] Preparation of Manshanhong II: Manshanhong purchased from the market is cleaned, selected, dried, crushed and sieved to obtain particles of about 2mm to 5mm.

[0034] Preparation of Rhododendron molle: After cleaning, selecting and drying the Rhododendron molle purchased from the market, cut it into sections of about 10mm.

[0035] Example 1 A method for preparing cough and asthma granules includes the following steps: S1. Extract to obtain a mixture, including the following steps: S11. Place 1000g of Manshanhong II into an extraction vessel, add 5000ml of 40% v / v ethanol aqueous solution, and then seal the extraction vessel.

[0036] S12. Turn on the ultrasound for 2 minutes. The ultrasound mode is pulsed, with a frequency of 30kHz, power of 100 W / cm², and amplitude of 50%. The pulse cycle is 2 seconds on and 3 seconds off, then turn off the ultrasound.

[0037] S13. Extraction, time is 72h. During the extraction, the stirring is turned on once on the evening of the first day for 10min. On the second and third days, the stirring is turned on once in the morning and once in the evening for 10min each time. The stirring speed is 180rpm each time.

[0038] In S12 and S13, the liquid temperature inside the extraction tank is controlled at around 35℃.

[0039] S2. Filter the mixture obtained in S1 to obtain filtrate and filter residue. Press the filter residue and filter the extracted liquid to obtain pressed filtrate. Combine the filtrate and pressed filtrate to obtain extract.

[0040] S3. Concentrate the extract to obtain a clear extract with a relative density of 1.15 at 75°C.

[0041] S4. Add lactic acid to the clear extract to adjust the pH to 4.5. While stirring, add chitosan aqueous solution (concentration of 2wt%, temperature of chitosan aqueous solution of 70℃, and amount of chitosan aqueous solution of 3 times the amount of clear extract), turn on the cooling and cool to 40℃.

[0042] S5. Filtrate through ultrafiltration membrane to obtain ultrafiltration filtrate. Concentrate the ultrafiltration filtrate to a clear extract with a relative density of 1.15 at 75°C. Spray dry the clear extract to obtain extract powder.

[0043] S6. Mix half of the extract powder from S5 with dextrin, adjust the mixture, prepare granules, dry, granulate, sieve, mix thoroughly, and package to obtain cough and asthma granules.

[0044] In S6, the total amount of extract powder and dextrin is 500g, and the amount of dextrin added is adjusted according to the amount of extract powder.

[0045] Example 2 Compared with Example 1, the difference is that in S11, Manshanhong III replaces Manshanhong II.

[0046] Example 3 Compared with Example 1, the difference is that in S11, Manshanhong 1 replaces Manshanhong 2.

[0047] Example 4 A method for preparing cough and asthma granules includes the following steps: S1. Extract to obtain a mixture, including the following steps: S11. Place 1000g of Manshanhong II into an extraction vessel, add 5000ml of 40% v / v ethanol aqueous solution, and then seal the extraction vessel.

[0048] S12. Turn on the ultrasound for 2 minutes. The ultrasound mode is pulsed, with a frequency of 30kHz, power of 100 W / cm², and amplitude of 50%. The pulse cycle is 2 seconds on and 3 seconds off, then turn off the ultrasound.

[0049] S13. Extraction, time is 72h. During the extraction, the stirring is turned on once on the evening of the first day for 10min. On the second and third days, the stirring is turned on once in the morning and once in the evening for 10min each time. The stirring speed is 180rpm each time.

[0050] In S12 and S13, the liquid temperature inside the extraction tank is controlled at around 35℃.

[0051] S2. Filter the mixture obtained in S1 to obtain filtrate and filter residue. Press the filter residue and filter the extracted liquid to obtain pressed filtrate. Combine the filtrate and pressed filtrate to obtain extract.

[0052] S3. Concentrate the extract to obtain a clear extract with a relative density of 1.15 at 75°C.

[0053] S4. Add lactic acid to the clear extract to adjust the pH to 5.5. While stirring, add chitosan aqueous solution (concentration of 2wt%, temperature of chitosan aqueous solution of 70℃, and amount of chitosan aqueous solution of 3 times the amount of clear extract), turn on the cooling and cool to 40℃.

[0054] S5. Filtrate through ultrafiltration membrane to obtain ultrafiltration filtrate. Concentrate the ultrafiltration filtrate to a clear extract with a relative density of 1.15 at 75°C. Spray dry the clear extract to obtain extract powder.

[0055] S6. Mix the extract powder from S5 with dextrin, adjust the mixture, prepare granules, dry, granulate, sieve, mix, and package to obtain the cough and asthma granules.

[0056] In S6, the total amount of extract powder and dextrin is 1000g, of which the amount of dextrin added is adjusted according to the amount of extract powder.

[0057] Example 5 The difference compared to Example 4 is that in S4, the pH of lactic acid was adjusted to 3.5.

[0058] Example 6 Compared with Example 4, the difference is that in S4, lactic acid is replaced with citric acid, and the pH is adjusted to 4.5 by citric acid.

[0059] Example 7 Compared with Example 4, the difference is that in S4, the pH of lactic acid is adjusted to 4.5, and chitosan is replaced with gelatin.

[0060] Example 8 Compared with Example 4, the difference is that in S4, lactic acid is replaced with citric acid, the pH of citric acid is adjusted to 4.5, and chitosan is replaced with gelatin.

[0061] Comparative Example 1 A method for preparing cough and asthma granules includes the following steps: S1. Extract to obtain a mixture, including the following steps: S11. Place 1000g of Manshanhong II into an extraction vessel, add 5000ml of 40% v / v ethanol aqueous solution, and then seal the extraction vessel.

[0062] S12. Turn on the ultrasound for 35 minutes. The ultrasound mode is pulsed, with a frequency of 30kHz, power of 100 W / cm², amplitude of 50%, and a pulse cycle of 2 seconds on and 3 seconds off.

[0063] In S12, the temperature of the liquid inside the extraction tank is controlled at around 35℃.

[0064] S2. Filter the mixture obtained in S1 to obtain filtrate and filter residue. Press the filter residue and filter the extracted liquid to obtain pressed filtrate. Combine the filtrate and pressed filtrate to obtain extract.

[0065] S3. Concentrate the extract to obtain a clear extract with a relative density of 1.15 at 75°C.

[0066] S4. Add lactic acid to the clear extract to adjust the pH to 4.5. While stirring, add chitosan aqueous solution (concentration of 2wt%, temperature of chitosan aqueous solution of 70℃, and amount of chitosan aqueous solution of 3 times the amount of clear extract), turn on the cooling and cool to 40℃.

[0067] S5. Filtrate through ultrafiltration membrane to obtain ultrafiltration filtrate. Concentrate the ultrafiltration filtrate to a clear extract with a relative density of 1.15 at 75°C. Spray dry the clear extract to obtain extract powder.

[0068] S6. Mix half of the extract powder from S5 with dextrin, adjust the mixture, prepare granules, dry, granulate, sieve, mix thoroughly, and package to obtain cough and asthma granules.

[0069] In S6, the total amount of extract powder and dextrin is 500g, and the amount of dextrin added is adjusted according to the amount of extract powder. Comparative Example 2 Compared with Comparative Example 1, the difference is that in S12, the ultrasonic mode is continuous rather than pulsed.

[0070] Comparative Example 3 A method for preparing cough and asthma granules includes the following steps: S1. Extract to obtain a mixture, including the following steps: S11. Place 1000g of Manshanhong II into an extraction vessel, add 5000ml of 40% v / v ethanol aqueous solution, and then seal the extraction vessel.

[0071] S13. Stir extraction for 72 hours at a stirring speed of 180 rpm.

[0072] In S13, the temperature of the liquid inside the extraction tank is controlled at around 35℃.

[0073] S2. Filter the mixture obtained in S1 to obtain filtrate and filter residue. Press the filter residue and filter the extracted liquid to obtain pressed filtrate. Combine the filtrate and pressed filtrate to obtain extract.

[0074] S3. Concentrate the extract to obtain a clear extract with a relative density of 1.15 at 75°C.

[0075] S4. Add lactic acid to the clear extract to adjust the pH to 4.5. While stirring, add chitosan aqueous solution (concentration of 2wt%, temperature of chitosan aqueous solution of 70℃, and amount of chitosan aqueous solution of 3 times the amount of clear extract), turn on the cooling and cool to 40℃.

[0076] S5. Filtrate through ultrafiltration membrane to obtain ultrafiltration filtrate. Concentrate the ultrafiltration filtrate to a clear extract with a relative density of 1.15 at 75°C. Spray dry the clear extract to obtain extract powder.

[0077] S6. Mix half of the extract powder from S5 with dextrin, adjust the mixture, prepare granules, dry, granulate, sieve, mix thoroughly, and package to obtain cough and asthma granules.

[0078] In S6, the total amount of extract powder and dextrin is 500g, and the amount of dextrin added is adjusted according to the amount of extract powder.

[0079] Comparative Example 4 A method for preparing cough and asthma granules includes the following steps: S1. Extract to obtain a mixture, including the following steps: S11. Place 1000g of Manshanhong II into an extraction vessel, add 5000ml of 40% v / v ethanol aqueous solution, and then seal the extraction vessel.

[0080] S13. Extraction, time is 168h. During the extraction, the stirring is turned on once in the morning and once in the evening, and the stirring time is 10min each time. The stirring speed is 180rpm each time.

[0081] In S13, the temperature of the liquid inside the extraction tank is controlled at around 35℃.

[0082] S2. Filter the mixture obtained in S1 to obtain filtrate and filter residue. Press the filter residue and filter the extracted liquid to obtain pressed filtrate. Combine the filtrate and pressed filtrate to obtain extract.

[0083] S3. Concentrate the extract to obtain a clear extract with a relative density of 1.15 at 75°C.

[0084] S4. Add lactic acid to the clear extract to adjust the pH to 4.5. While stirring, add chitosan aqueous solution (concentration of 2wt%, temperature of chitosan aqueous solution of 70℃, and amount of chitosan aqueous solution of 3 times the amount of clear extract), turn on the cooling and cool to 40℃.

[0085] S5. Filtrate through ultrafiltration membrane to obtain ultrafiltration filtrate. Concentrate the ultrafiltration filtrate to a clear extract with a relative density of 1.15 at 75°C. Spray dry the clear extract to obtain extract powder.

[0086] S6. Mix half of the extract powder from S5 with dextrin, adjust the mixture, prepare granules, dry, granulate, sieve, mix thoroughly, and package to obtain cough and asthma granules.

[0087] In S6, the total amount of extract powder and dextrin is 500g, and the amount of dextrin added is adjusted according to the amount of extract powder.

[0088] The total flavonoids and rhododendron granules from Examples 1-3 and Comparative Examples 1-4 were tested, and the results are shown in Table 1 below. Table 1. Results of total flavonoids (calculated as rutin) and rhododendronin detection In Table 1, the values ​​represent the content in one packet of cough and asthma granules (weighing 2g).

[0089] Accelerated stability tests were conducted on the extract powders of Examples 1-3 and Comparative Examples 1-4 (0 months, 3 months, and 12 months, respectively). The test conditions were: temperature 40℃±2℃ and relative humidity 75%±5%. The solubility of the extract powders after the accelerated test was tested. The solubility solvent was 40% v / v ethanol aqueous solution, 200 ml of ethanol aqueous solution, and the amount of solubility sample was 2 g. The detection equipment was a turbidimeter. The results are shown in Table 2 below.

[0090] Table 2 Solubility test results In Table 2, the turbidity change value is based on the turbidity value of the sample in month 0, and the turbidity value of the sample in months 3 / 9 minus the turbidity value of the sample in month 0.

[0091] As shown in Table 1, although the extraction time was shortened compared to Comparative Example 4, the content of the target component in Examples 1-3 was not significantly different. Comparative Examples 1-3 showed better extraction results compared to Example 1. However, Table 2 shows that although the turbidity of Examples 1-3 increased after 3 and 12 months of accelerated testing, the increase was not significant. Example 2 showed the smallest change, while Comparative Examples 1-4 showed larger turbidity changes, with Comparative Example 1 even showing a change of 12.55 NTU after 3 months and 17.55 NTU after 12 months. In summary, Examples 1-3, while maintaining the efficacy of the newly prepared cough and asthma granules, shortened the extraction time and improved product stability, resulting in a longer shelf life.

[0092] The astringent taste of the cough and asthma granules from Examples 1, 4-8 was compared, and the results are shown in Table 3 below.

[0093] The astringency assessors are selected from personnel who are not involved in the extraction and production of Chinese medicinal materials. The assessors are people who are sensitive to astringency, and there are at least 6 assessors.

[0094] During the evaluation, before evaluating each sample, rinse your mouth with room temperature purified water. Use a special dropper or small spoon to take about 3-5 mL of sample liquid and place it in your mouth. Gently sip the liquid to distribute it evenly in the front of your mouth, avoiding swallowing. Let the liquid contact the entire oral cavity for about 5-8 seconds, focusing on the astringent sensation on the tongue, palate, and inner cheeks.

[0095] The evaluation rules are as follows: the astringency of the sample liquid in Example 6 is used as the benchmark and is recorded as 1. If the astringency is stronger than that of Example 6, it is represented by 1+. If the astringency is lighter than that of Example 6, it is represented by 1-. The more +, the stronger the astringency; the more -, the lighter the astringency.

[0096] Table 3 Astringency test results As can be seen from Table 3, the astringency of Examples 6-8 is basically the same, and the reviewers cannot distinguish between Examples 7 and 8 and Examples 6. The astringency of Examples 4 and 5 is lighter than that of Example 6 (1-), and the astringency of Example 1 is even lighter (1- -).

[0097] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A method for preparing cough and asthma granules, characterized in that, Includes the following steps: S1. Closed extraction to obtain a mixture: Rhododendron molle was first subjected to pulsed sonication in an ethanol-water solution for 1 min to 3 min, and then extracted for 66 h to 78 h at a temperature of 30℃ to 40℃, with intermittent stirring during the extraction process; S2. Filter the mixture obtained in S1 to obtain filtrate and filter residue. Press the filter residue and filter the extract to obtain pressed filtrate. Combine the filtrate and pressed filtrate to obtain extract. S3. Concentrate the extract to a clear paste with a relative density of 1.10 to 1.2 at 70℃ to 80℃; S4. Add a pH adjuster to the ointment to adjust the pH to 3.5~5.5, and add the astringent solution while stirring to remove astringency; S5. Ultrafiltration membrane filtration, concentrating the ultrafiltration filtrate to obtain a clear extract with a relative density of 1.10~1.2 at 70℃~80℃, and spray drying the clear extract to obtain an extract powder; S6. Mix the extract powder with excipients, prepare granules, dry, granulate, sieve, mix, and package to obtain cough and asthma granules.

2. The method for preparing the cough-relieving and asthma-relieving granules according to claim 1, characterized in that, In S1, the pulsed ultrasound has a frequency of 20kHz~40kHz, a power of 90 W / cm²~110 W / cm², an amplitude of 45~55%, and a pulse period of 2 seconds on and 3 seconds off.

3. The method for preparing the cough and asthma granules according to claim 1, characterized in that, In S1, intermittent stirring is started once on the evening of the first day, with a stirring time of 8 to 12 minutes. From the second day onwards, stirring is started once each in the morning and evening, with a stirring time of 8 to 12 minutes. The stirring speed for each stirring is 170 to 190 rpm.

4. The method for preparing the cough and asthma granules according to claim 1, characterized in that, In S1, the volume of the ethanol-water solution is 4500ml~5500ml of ethanol-water solution per 1000g of *Rhododendron molle*, and the ethanol-water solution is 30%v / v~50%v / v ethanol-water solution.

5. The method for preparing the cough and asthma granules according to claim 1, characterized in that, In S1, the size of the rhododendron is 2mm~5mm.

6. The method for preparing the cough-relieving and asthma-relieving granules according to any one of claims 1-5, characterized in that, In S4, the pH adjuster is lactic acid, and the deastringency-removing aqueous solution is a chitosan aqueous solution.

7. The method for preparing the cough and asthma granules according to claim 6, characterized in that, The chitosan aqueous solution is a chitosan aqueous solution of 1.5 wt% to 2.5 wt%, and the amount of chitosan aqueous solution is 2.8 to 3.3 times the amount of the extract obtained in S3.

8. The method for preparing the cough and asthma granules according to claim 6, characterized in that, In S4, the pH is 4.5.

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