Adsorption resin for removing tumor cell factors and preparation method thereof
By preparing a tumor cytokine adsorption resin with specific adsorption effect, the problem of distant tissue lesions caused by tumor cells spreading through the blood has been solved, achieving efficient clearance of tumor cells and blocking cancer spread, thus supporting patient survival.
Patent Information
- Application Number
- CN202511349088.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-09-22
- Publication Date
- 2025-11-18
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
In existing technologies, cancer metastasis and spread mainly occur through blood, lymph nodes, etc. Tumor cells spread through the blood, causing lesions in distant tissues and organs, and there is a lack of effective blood purification methods to block the spread of tumor cells.
Using natural polymer materials such as cellulose and agarose as carriers, functional ligands are bonded through chemical or physical methods to prepare tumor cytokine adsorption resins with specific adsorption effects. The resins remove tumor cytokines by utilizing the principles of bioaffinity or chemisorption, and the scaffold structure facilitates the replacement and disassembly of the reaction vessel.
It achieves efficient adsorption and removal of tumor cytokines, supports blood purification to block tumor cell metastasis, delays cancer spread, and provides time for surgical treatment.
Smart Images
Figure CN120961129A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of adsorption resin technology, and in particular to an adsorption resin for removing tumor cytokines and its preparation method. Background Technology
[0002] Adsorption resins refer to a class of high molecular weight polymers used for removing organic matter from wastewater, decolorizing sugar solutions, and separating and purifying natural products and biochemicals. There are many types of adsorption resins; variations in monomers and functional groups can endow them with various special properties. Commonly used resins include polystyrene resins and polyacrylate resins.
[0003] Currently, in existing technologies, cancer metastasis and spread mainly occur through blood and lymph nodes. However, when metastasizing to distant tissues and organs, tumor cells spread through the blood, causing lesions in other organs and tissues. Therefore, blood purification can be used to block the metastasis and spread of tumor cells, prevent the tumor from expanding further, and buy time for surgical treatment or patient survival. Therefore, this invention proposes an adsorbent resin for removing tumor cytokines and its preparation method. Summary of the Invention
[0004] The purpose of this invention is to address the shortcomings of existing technologies in cancer metastasis and spread, which mainly occur through blood and lymph nodes. However, when cancer metastasizes to distant tissues and organs, tumor cells spread through the blood, leading to lesions in other organs and tissues.
[0005] To achieve the above objectives, the present invention employs the following technical solution: a resin for removing tumor cytokines and a method for preparing the same, the preparation method comprising: S1. First, natural polymer materials such as cellulose and agarose are used as carriers. Functional ligands are linked to the carriers through chemical or physical methods, which have a specific adsorption effect on tumor cytokines. S2. Simultaneously, natural polymer materials such as cellulose and agarose are placed in the reaction vessel for reaction preparation. S3. By linking corresponding ligands to the carrier, corresponding antibodies / antigens, amino acids, proteins, etc. can be prepared for different tumors. These can adsorb and remove tumor cytokines through bioaffinity or chemisorption principles. The preparation device includes a support mechanism, in which a reaction vessel body is installed. A positioning mechanism is installed below the support mechanism, and the support mechanism drives the positioning mechanism to replace the reaction vessel body.
[0006] In at least some embodiments, the support mechanism includes four connecting blocks, which are rectangular in shape, and a fixed connecting rod is fixedly connected between two of the connecting blocks. A sliding rod is fixedly connected to the inner side of two of the connecting blocks on one side, and a slide rail is fixedly connected to the inner side of two of the connecting blocks on the other side. The sliding rod is slidably installed in the slide rail.
[0007] In at least some embodiments, one end of each slide rod is engaged with an adjusting screw, each adjusting screw is rotatably mounted on a connecting block, a rotating shaft is provided near the adjusting screw, each rotating shaft is rotatably mounted on the outer wall of a fixed connecting rod, and a supporting column is fixedly connected to the lower surface of each connecting block.
[0008] In at least some embodiments, each of the adjusting screws extends outward from the connecting block, and each of the rotating shafts and the adjusting screws is fitted with a sprocket on the same section, each of the sprockets is driven by a chain, and one end of each of the rotating shafts is fixedly connected to a driven gear.
[0009] In at least some embodiments, a drive gear is meshed below the driven gear, the output shaft of a drive motor is fixedly connected to the center of the drive gear, and the drive motor is fixedly connected to the lower surface of the fixed connecting rod.
[0010] In at least some embodiments, the positioning mechanism includes a pad block fixed to the lower end of a support column, a mounting sheet metal fixed to one side of the pad block, a central shaft fixed inside the mounting sheet metal, and a rotating assembly rotatably mounted on the central shaft.
[0011] In at least some embodiments, a rocker arm is fixedly connected to one side of the rotating assembly, a roller is rotatably mounted on the rocker arm, a mounting base is fixedly connected to the lower surface of the rotating assembly, an L-shaped connecting rod is rotatably mounted inside the mounting base, and a limit block is fixedly connected to one end of the L-shaped connecting rod.
[0012] In at least some embodiments, a transmission link is rotatably mounted on the upper end of the limiting block, a connector is rotatably mounted on the upper end of the transmission link, a movable rod is fixedly connected to the upper surface of the connector, and a limiting sleeve is slidably mounted on the outer side of the movable rod.
[0013] In at least some embodiments, a fixed bracket is fixedly connected to the outer side of the limiting sleeve, the fixed bracket is fixedly connected to the upper surface of the pad, a compression spring is sleeved on the upper end of the movable rod, and the lower end of the compression spring is fixedly connected to the upper surface of the fixed bracket.
[0014] Compared with the prior art, the advantages and positive effects of the present invention are as follows: 1. In this invention, the drive motor drives the drive gear to rotate, which in turn drives the driven gear to rotate. The rotating shaft drives the adjusting screw to rotate through the sprocket and chain transmission. The adjusting screw is engaged with the slide rod, which can achieve the effect of adjusting the distance between the slide rod and the slide rail. Since the support column is equipped with clamps, it is convenient to replace and disassemble the reaction vessel body.
[0015] 2. In this invention, pressing the movable rod tightens the compression spring. The lower end of the movable rod is connected to a transmission link through a connector, which can push the rotating kit to rotate around the central axis. The rotation of the rotating kit can cooperate with the extension of the roller to move the equipment. It can also drive the limit block to extend to lock and position the roller. Attached Figure Description
[0016] Figure 1 This invention provides a three-dimensional schematic diagram of one side of an adsorbent resin for removing tumor cytokines and its preparation method. Figure 2 This invention provides a three-dimensional schematic diagram of a combined scaffold and positioning mechanism for a resin used to remove tumor cytokine adsorption and its preparation method. Figure 3 This invention presents a three-dimensional schematic diagram of the overall structure of a scaffold mechanism for removing adsorbed resins for tumor cytokines and its preparation method. Figure 4 This invention provides a three-dimensional schematic diagram of a scaffold mechanism for a resin used to remove tumor cytokines and its preparation method. Figure 5 This invention provides a three-dimensional schematic diagram of the overall partial structure of an adsorbent resin for removing tumor cytokines and its preparation method. Figure 6 This invention presents a three-dimensional schematic diagram of the overall structure of a positioning mechanism for a resin adsorbed to remove tumor cytokines and its preparation method.
[0017] Legend: 100, Support mechanism; 200, Positioning mechanism; 300, Reactor body; 101, Connecting block; 102, Fixed connecting rod; 103, Slide rod; 104, Slide rail; 105, Adjusting screw; 106, Sprocket; 107, Drive motor; 108, Chain; 109, Driven gear; 110, Rotating shaft; 111, Drive gear; 112, Support column; 201, Pad; 202, Fixed bracket; 203, Limiting sleeve; 204, Movable rod; 205, Compression spring; 206, Connecting piece; 207, Transmission connecting rod; 208, Mounting sheet metal; 209, Central shaft; 210, Rotating assembly; 211, Mounting base; 212, Limiting block; 213, L-shaped connecting rod; 214, Rocker arm; 215, Roller. Detailed Implementation
[0018] To better understand the above-mentioned objectives, features, and advantages of the present invention, the present invention will be further described below in conjunction with the accompanying drawings and embodiments. It should be noted that, unless otherwise specified, the embodiments and features described in these embodiments can be combined with each other.
[0019] Numerous specific details are set forth in the following description in order to provide a full understanding of the invention. However, the invention may also be practiced in other ways than those described herein, and therefore the invention is not limited to the specific embodiments disclosed in the following specification.
[0020] Example, according to Figures 1-5 ,like Figures 1-5 As shown in the embodiment of the present invention, an adsorbent resin for removing tumor cytokines and its preparation method are provided. The preparation method includes: S1. First, natural polymer materials such as cellulose and agarose are used as carriers. Functional ligands are linked to the carriers through chemical or physical methods, which have a specific adsorption effect on tumor cytokines. S2. Simultaneously, natural polymer materials such as cellulose and agarose are placed in the reaction vessel for reaction preparation. S3. By linking corresponding ligands to the carrier, corresponding antibodies / antigens, amino acids, proteins, etc. can be prepared for different tumors. These can adsorb and remove tumor cytokines through bioaffinity or chemisorption principles. The preparation device includes a support mechanism 100, in which a reaction vessel body 300 is installed. A positioning mechanism 200 is installed below the support mechanism 100. The support mechanism 100 drives the positioning mechanism 200 to replace the reaction vessel body 300.
[0021] like Figures 3-4As shown, the support mechanism 100 includes four connecting blocks 101, which are rectangular in shape. A fixed connecting rod 102 is fixedly connected between two of the connecting blocks 101. A sliding rod 103 is fixedly connected to the inner side of two connecting blocks 101 on one side, and a slide rail 104 is fixedly connected to the inner side of two connecting blocks 101 on the other side. The sliding rod 103 is slidably installed within the slide rail 104. One end of each sliding rod 103 is engaged with an adjusting screw 105. Each adjusting screw 105 is rotatably mounted on a connecting block 101. A rotating shaft 110 is also provided near the adjusting screw 105. Each rotating shaft 110 is rotatably mounted on the outer wall of the fixed connecting rod 102. A supporting column 112 is fixedly connected to the lower surface of each connecting block 101. Each adjusting screw 105 extends outward from the connecting block 101, and each rotating shaft 110 and adjusting rod 112 are connected to the adjusting rod 102. A sprocket 106 is sleeved on the same section of the lead screw 105. A chain 108 is driven and installed on each sprocket 106. A driven gear 109 is fixedly connected to one end of each rotating shaft 110. A drive gear 111 is meshed and connected below the driven gear 109. The output shaft of a drive motor 107 is fixedly connected to the center of the drive gear 111. The drive motor 107 is fixedly connected to the lower surface of the fixed connecting rod 102. The drive motor 107 drives the drive gear 111 to rotate, which in turn drives the driven gear 109 to rotate. The rotating shaft 110 drives the adjusting lead screw 105 to rotate through the sprocket 106 and the chain 107. The adjusting lead screw 105 is meshed and connected to the slide rod 103, which can achieve the effect of adjusting the distance between the slide rod 103 and the slide rail 104. Since the support column 112 is equipped with a clamp, it is convenient to replace and disassemble the reactor body 300.
[0022] like Figures 5-6As shown, the positioning mechanism 200 includes a pad 201, which is fixed to the lower end of the support column 112. A mounting sheet metal 208 is fixed to one side of the pad 201. A central shaft 209 is fixed inside the mounting sheet metal 208. A rotating assembly 210 is rotatably mounted on the central shaft 209. A rocker arm 214 is fixed to one side of the rotating assembly 210. A roller 215 is rotatably mounted on the rocker arm 214. A mounting base 211 is fixed to the lower surface of the rotating assembly 210. An L-shaped connecting rod 213 is rotatably mounted inside the mounting base 211. A limit block 212 is fixed to one end of the L-shaped connecting rod 213. A transmission connecting rod 207 is rotatably mounted on the upper end of the limit block 212. A connecting piece 206 is rotatably mounted on the upper end of the transmission connecting rod 207. A movable rod 204 is fixedly connected to the upper surface of the 06. A limiting sleeve 203 is slidably installed on the outer side of the movable rod 204. A fixed bracket 202 is fixedly connected to the outer side of the limiting sleeve 203. The fixed bracket 202 is fixedly connected to the upper surface of the pad 201. A compression spring 205 is sleeved on the upper end of the movable rod 204. The lower end of the compression spring 205 is fixedly connected to the upper surface of the fixed bracket 202. Pressing the movable rod 204 tightens the compression spring 205. The lower end of the movable rod 204 is connected to a transmission link 207 through a connector 206, which can push the rotating assembly 210 to rotate around the central axis 209. The rotation of the rotating assembly 210 can cooperate with the extension of the roller 215 to move the equipment. It can also drive the limiting block 212 to extend and lock the roller 215.
[0023] The working principle of this invention is as follows: Pressing the movable rod 204 tightens the compression spring 205. The lower end of the movable rod 204 is connected to the transmission link 207 via the connector 206, which can push the rotating assembly 210 to rotate around the central axis 209. The rotation of the rotating assembly 210 can cooperate with the extension of the roller 215 to move the equipment. It can also drive the limit block 212 to extend and lock the roller 215. The drive motor 107 drives the drive gear 111 to rotate, which in turn drives the driven gear 109 to rotate. The rotating shaft 110 drives the adjusting screw 105 to rotate via the sprocket 106 and chain 107. The adjusting screw 105 is engaged with the slide rod 103, which can adjust the distance between the slide rod 103 and the slide rail 104. Since the support column 112 is equipped with a clamp, it is convenient to replace and disassemble the reactor body 300.
[0024] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention in any other way. Any person skilled in the art may make changes or modifications to the above-disclosed technical content to create equivalent embodiments that can be applied to other fields. However, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the protection scope of the present invention.
Claims
1. A resin for adsorbing tumor cytokines and its preparation method, characterized in that, The preparation method includes: S1. First, natural polymer materials such as cellulose and agarose are used as carriers. Functional ligands are linked to the carriers through chemical or physical methods, which have a specific adsorption effect on tumor cytokines. S2. Simultaneously, natural polymer materials such as cellulose and agarose are placed in the reaction vessel for reaction preparation. S3. By linking corresponding ligands to the carrier, corresponding antibodies / antigens, amino acids, proteins, etc. can be prepared for different tumors. These can adsorb and remove tumor cytokines through bioaffinity or chemisorption principles. The preparation device includes a support mechanism (100), in which a reaction vessel body (300) is installed, and a positioning mechanism (200) is installed below the support mechanism (100). The support mechanism (100) drives the positioning mechanism (200) to replace the reaction vessel body (300).
2. The adsorbent resin for removing tumor cytokines and its preparation method according to claim 1, characterized in that: The support mechanism (100) includes four connecting blocks (101), which are rectangular in shape. A fixed connecting rod (102) is fixed between two of the connecting blocks (101). A sliding rod (103) is fixed inside the two connecting blocks (101) on one side, and a slide rail (104) is fixed inside the two connecting blocks (101) on the other side. The sliding rod (103) is slidably installed in the slide rail (104).
3. The adsorbent resin for removing tumor cytokines and its preparation method according to claim 1, characterized in that: Each of the slide rods (103) is engaged with an adjusting screw (105) at one end. Each adjusting screw (105) is rotatably mounted on a connecting block (101). A rotating shaft (110) is also provided on the side near the adjusting screw (105). Each rotating shaft (110) is rotatably mounted on the outer wall of the fixed connecting rod (102). A supporting column (112) is fixedly connected to the lower surface of each connecting block (101).
4. The adsorbent resin for removing tumor cytokines and its preparation method according to claim 3, characterized in that: Each of the adjusting screws (105) extends out of the connecting block (101), and each of the rotating shafts (110) and the adjusting screws (105) is fitted with a sprocket (106) on the same section. Each of the sprockets (106) is equipped with a chain (108) for transmission, and one end of each of the rotating shafts (110) is fixedly connected to a driven gear (109).
5. The adsorbent resin for removing tumor cytokines and its preparation method according to claim 4, characterized in that: The driven gear (109) is meshed with a drive gear (111) below it. The output shaft of the drive motor (107) is fixedly connected to the center of the drive gear (111). The drive motor (107) is fixedly connected to the lower surface of the fixed connecting rod (102).
6. The adsorbent resin for removing tumor cytokines and its preparation method according to claim 1, characterized in that: The positioning mechanism (200) includes a pad (201), which is fixed to the lower end of the support column (112). A mounting sheet metal (208) is fixed to one side of the pad (201), and a central shaft (209) is fixed inside the mounting sheet metal (208). A rotating assembly (210) is rotatably mounted on the central shaft (209).
7. The adsorbent resin for removing tumor cytokines according to claim 6 and its preparation method, characterized in that: A rocker arm (214) is fixedly connected to one side of the rotating assembly (210), and a roller (215) is rotatably mounted on the rocker arm (214). A mounting base (211) is fixedly connected to the lower surface of the rotating assembly (210), and an L-shaped connecting rod (213) is rotatably mounted inside the mounting base (211). A limit block (212) is fixedly connected to one end of the L-shaped connecting rod (213).
8. The adsorbent resin for removing tumor cytokines according to claim 7 and its preparation method, characterized in that: The upper end of the limiting block (212) is rotatably mounted with a transmission link (207), the upper end of the transmission link (207) is rotatably mounted with a connector (206), the upper surface of the connector (206) is fixedly connected with a movable rod (204), and a limiting sleeve (203) is slidably mounted on the outer side of the movable rod (204).
9. The adsorbent resin for removing tumor cytokines and its preparation method according to claim 8, characterized in that: A fixed bracket (202) is fixedly connected to the outside of the limiting sleeve (203). The fixed bracket (202) is fixedly connected to the upper surface of the pad (201). A compression spring (205) is sleeved on the upper end of the movable rod (204). The lower end of the compression spring (205) is fixedly connected to the upper surface of the fixed bracket (202).