Intelligent mixing device for biochemical sample pretreatment

Abstract

The application provides an intelligent mixing device for biochemical sample pretreatment, solves the problem of low mixing efficiency of the tube pressing type mixing device, and the permanent deformation or damage of the rubber tube material affects the mixing efficiency and the accuracy of liquid metering. The application comprises a control console, the top of the control console is provided with two vertical stands arranged at intervals left and right, the two vertical stands are both fixedly provided with arc-shaped tracks arranged vertically and in an arc-shaped structure, a mounting plate is slidably connected between the two arc-shaped tracks, a plurality of test tubes are arranged at intervals left and right and are provided with upper openings in the mounting plate, a detachable rubber plug is arranged at the upper opening of the test tube, a ring-shaped magnet is fixedly arranged at the top of the rubber plug, a hollow tube is arranged in the rubber plug and penetrates the rubber plug from top to bottom, a plunger capable of moving up and down is movably arranged in the hollow tube, a cylindrical magnet is fixedly arranged at the top of the plunger, the top of the two vertical stands is provided with a crosspiece that spans all the test tubes, and the bottom of the crosspiece is provided with a plurality of detachable electromagnets.

Description

Technical Field

[0001] This invention relates to the field of sample processing equipment technology, and in particular to an intelligent mixing device for biochemical sample pretreatment. Background Technology

[0002] Currently, instruments that require adding the sample to a reaction tube for incubation before conducting sample testing and analysis include hematology analyzers, fully automated chemiluminescence immunoassay analyzers, and fully automated biochemical analyzers. To ensure a complete reaction and guarantee the accuracy and repeatability of the instrument's test results, the sample and reagents must be thoroughly mixed. The degree of mixing directly affects the accuracy and repeatability of the test results.

[0003] Patent application number 201711392317.4 discloses a mixing device and method for test samples in the reaction cell of an analyzer, which includes a reaction cell, an optical measurement module, and a rubber tube connecting the reaction cell and the optical measurement module; the reaction cell has multiple reagent inlets and a waste liquid outlet designed directly below it. Below the reagent inlets, near the bottom of the inner cavity of the reaction cell, a sample channel is designed. The reagent inlets are used to add reagents to the reaction cell. The waste liquid outlet is connected to the waste liquid module. The sample channel and the optical measurement module are connected by a pipeline. A tube-pressing valve is provided on the rubber tube connecting the sample channel and the optical measurement module. The tube-pressing valve repeatedly draws the sample liquid out of the reaction cell and pushes it back into the reaction cell by repeatedly pressing and releasing the rubber tube. However, this tube-pressing mixing device has the following disadvantages when used: (1) Uniform flow field: The liquid flow generated by the tube-pressing operation is mainly a "piston flow" in the front and back direction. This unidirectional flow is very inefficient in breaking up liquid stratification, especially the sediment at the bottom of the reaction cell, which is the key to efficient mixing. (2) "Dead zone" exists: In the corners or edges of the reaction cell far from the sample channel area, the liquid may not be effectively moved, forming a mixing "dead zone", resulting in uneven sample or reagent concentration. (3) Tube fatigue and aging: Repeated squeezing and releasing will cause the tube material to fatigue quickly, resulting in permanent deformation or damage. This will change the volume pushed and drawn each time, affecting the mixing efficiency and the accuracy of liquid measurement, requiring frequent tube replacement, increasing maintenance costs and failure risk. Summary of the Invention

[0004] To address the problems of low mixing efficiency and permanent deformation or damage caused by the tubing material in the prior art of pressure-type mixing devices, which affect mixing efficiency and accuracy of liquid measurement, this invention proposes an intelligent mixing device for biochemical sample pretreatment.

[0005] The technical solution of the present invention is: an intelligent mixing device for biochemical sample pretreatment, including a control console, a controller inside the control console, two uprights spaced apart on the top of the control console, and arc-shaped tracks with vertical arrangement and arc structure fixed on each of the two uprights. A mounting plate is slidably connected between the two arc tracks, and the mounting plate can swing like a rocker between the two arc tracks. Multiple test tubes with left and right spacing and open tops are inserted on the mounting plate.

[0006] Several vertically arranged linear bearings are fixedly mounted on the mounting plate. A ring plate is fixedly mounted on the top of the linear bearing and is coaxially arranged with it. Several springs are fixedly connected to the top of the ring plate and are arranged at intervals around it. A retaining plate is fixedly connected to the top of each spring.

[0007] A test tube is movably inserted inside the linear bearing. The upper end of the test tube has an annular edge. A slot is opened on the side of the clamping plate facing the edge. The clamping plate can be detachably clamped on the edge through the slot. The outer diameter of the test tube is equal to the inner diameter of the linear bearing. The test tube can move up and down inside the linear bearing.

[0008] The test tube has a removable rubber stopper at the top opening. A ring magnet is fixed to the top of the rubber stopper. A hollow tube that is open at both ends is inserted inside the rubber stopper. The upper end of the hollow tube extends into the space inside the ring magnet, and the lower end of the hollow tube is inserted into the test tube.

[0009] A plunger capable of moving up and down is movably inserted inside the hollow tube. The inner diameter of the hollow tube is equal to the outer diameter of the plunger. A cylindrical magnet is fixed on the top of the plunger, and the upper end of the cylindrical magnet has the same magnetic pole as the upper end of the ring magnet.

[0010] The top of the two uprights is equipped with a crossbar that spans all the test tubes. At the bottom of the crossbar are multiple detachable electromagnets. The electromagnets are located directly above the ring magnet and the cylindrical magnet. All the electromagnets are electrically connected to the controller, and all the electromagnets are connected in parallel.

[0011] The control panel is equipped with at least two push-button switches, both of which are electrically connected to the controller.

[0012] One of the push-button switches can control all the electromagnets to intermittently switch on and off or change the direction of current in a direction from left to right or from right to left. When changing the direction of current, the magnetic poles of the leftmost electromagnet and the rightmost electromagnet are always opposite during the process of changing the direction of current.

[0013] Another push switch can control all electromagnets to intermittently switch on and off or change the direction of current at the same time through the controller, and when changing the direction of current, the magnetic poles below all electromagnets are always the same during the process of changing the direction of current.

[0014] Preferably, an H-bridge driver chip is connected between the electromagnet and the controller, so that the controller can control the direction of the magnetic poles of the electromagnet after it is energized through the H-bridge driver chip.

[0015] Preferably, the control panel is equipped with a display screen and an adjustable potentiometer. The display screen and the adjustable potentiometer are electrically connected to the controller. The adjustable potentiometer can adjust the frequency of the electromagnet's current direction change through the controller, and the display screen is used to display the frequency of the electromagnet's current direction change.

[0016] Preferably, the top of the control console is equipped with multiple low-frequency ultrasonic generators spaced apart horizontally. The low-frequency ultrasonic generators are connected to the controller and are located directly below each test tube in a natural vertical position.

[0017] Preferably, the top of the console is fixedly provided with a straight track extending in the left and right direction, and two first sliders spaced apart on the straight track are slidably provided. A positioning screw is threaded through the first slider and connected to it. One end of the positioning screw abuts against the straight track to fix the position of the first slider. The lower ends of the two uprights are fixedly connected to the tops of the two first sliders respectively.

[0018] The mounting plate includes two edge unit plates and multiple middle unit plates located between the two edge unit plates. The edge unit plates and middle unit plates can be detachably connected in the left and right directions. Each edge unit plate and middle unit plate is equipped with a test tube, and the end of the edge unit plate facing the arc track is slidably connected to the arc track.

[0019] Preferably, a plurality of second sliders are slidably arranged on the linear track, and each low-frequency ultrasonic generator is fixedly mounted on the top of each second slider.

[0020] Preferably, the crossbeam is a portal frame structure, with one end of the crossbeam rotatably and detachably connected to the top of one of the uprights, and the other end of the crossbeam detachably connected to the top of another upright.

[0021] Preferably, positioning magnets are fixedly provided at the bottom of the other end of the cross frame and the top of the other upright frame, and the two positioning magnets can attract each other to fix the position of the other end of the cross frame.

[0022] The advantages of this invention are as follows: During use, the controller intermittently starts and stops the electromagnets at different positions, which in turn pushes the annular and cylindrical magnets below them. When the annular magnets at different locations are pushed, they drive the mounting plate to swing back and forth between two arc-shaped tracks, creating a "left-right shaking" mixing effect for the sample liquid in the test tube. During this process, the cylindrical magnet, simultaneously propelled by the attraction or repulsion of the electromagnets and by the hydraulic pressure between the sample liquid inside the test tube and the liquid inside the hollow tube, moves back and forth within the hollow tube. This causes the lower end of the hollow tube to draw in and discharge the sample liquid from the test tube, agitating the sample liquid within the test tube. This results in high mixing efficiency and avoids the problems of deformation or damage to the tubing material in pressure-type mixing devices, which can affect mixing efficiency and the accuracy of liquid measurement. Attached Figure Description

[0023] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0024] Figure 1 This is a schematic diagram of the intelligent mixing device in Example 1 when three electromagnets work simultaneously;

[0025] Figure 2 This is a state diagram of the intelligent mixing device when the electromagnet at the far right in Example 1 is working alone.

[0026] Figure 3 for Figure 1 A schematic diagram of the test tubes and racks in the diagram;

[0027] Figure 4 for Figure 3 A planar structural diagram of the rubber stopper and its components from a top view.

[0028] Figure 5 for Figure 1 A three-dimensional structural diagram of the arc-shaped track in the diagram;

[0029] Figure 6 This is a schematic diagram of the circuit principle for controlling the direction and frequency of current change of an electromagnet using an adjustable potentiometer in Example 1.

[0030] Figure 7 This is a schematic diagram of the circuit principle for controlling the frequency of current switching on and off of an electromagnet using an adjustable potentiometer in Example 2.

[0031] In the diagram, 1. Control console, 2. Display screen, 3. Push-button switch, 4. Linear track, 5. First slider, 6. Positioning screw, 7. Second slider, 8. Low-frequency ultrasonic generator, 9. Stand, 10. Arc track, 1001. Arc track groove, 11. Edge unit plate, 12. Middle unit plate, 13. Connecting plate, 14. Linear bearing, 15. Test tube, 16. Ring plate, 17. Spring, 18. Connecting rod, 19. Clamping plate, 20. Rubber stopper, 21. Ring magnet, 22. Hollow tube, 23. Plunger, 24. Cylindrical magnet, 25. Fixing sleeve, 26. Horizontal frame, 27. Fixing rod, 28. Positioning magnet block, 29. Electromagnet, 30. Adjustable potentiometer. Detailed Implementation

[0032] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0033] Example 1: An intelligent mixing device for biochemical sample pretreatment, such as... Figure 1 and Figure 2 As shown, console 1 is included, and a controller (not shown in the figure) is located inside console 1.

[0034] In order to adjust the number of test tubes 15 installed, in this embodiment, as follows: Figure 1 and Figure 2 As shown, a straight track 4 extending in the left-right direction is fixedly provided on the top of the control console 1. Two first sliders 5 are slidably arranged on the straight track 4 with left and right intervals. A positioning screw 6 is threadedly connected to the first slider 5. One end of the positioning screw 6 abuts against the straight track 4 to fix the position of the first slider 5 on the straight track 4.

[0035] The tops of the two first sliders 5 are respectively fixedly connected to the lower end of a stand 9. Each of the two stands 9 is fixedly equipped with a vertically arranged, arc-shaped track 10, such as... Figure 5 As shown, an arc-shaped track groove 1001 is provided on the arc-shaped track 10. The cross-section of the arc-shaped track groove 1001 is a T-shaped groove structure. In other embodiments, the cross-section of the arc-shaped track groove 1001 can also adopt a dovetail groove structure.

[0036] A mounting plate is slidably connected between two arc-shaped tracks 10 on the left and right sides. The mounting plate can swing back and forth between the two arc-shaped tracks 10. Multiple test tubes 15 with left and right intervals and open tops are inserted through the mounting plate. Specifically, the mounting plate includes two edge unit plates 11 and multiple middle unit plates 12 located between the two edge unit plates 11. The edge unit plates 11 and the middle unit plates 12 can be detachably connected in the left and right directions. In this embodiment, the end of the edge unit plate 11 facing the middle unit plate 12 and the left and right ends of the middle unit plate 12 are provided with first screw holes that are open from top to bottom. Connecting plates 13 are provided on the upper and lower sides of the splicing points of the edge unit plates 11 and the middle unit plates 12, and the splicing points of two adjacent middle unit plates 12. The connecting plates 13 are provided with second screw holes that are corresponding to the first screw holes. Fixing bolts are inserted in the first screw holes and the second screw holes. The connecting plates 13, the edge unit plates 11 and the middle unit plates 12 are connected into one unit by fixing bolts.

[0037] The edge unit plate 11 is provided with a T-shaped head structure that is adapted to the arc-shaped track groove 1001 at one end facing the arc-shaped track 10. The edge unit plate 11 is slidably connected to the arc-shaped track 10 through the T-shaped head structure and the arc-shaped track groove 1001.

[0038] Each edge unit plate 11 and the middle unit plate 12 is fixedly fitted with a vertically arranged linear bearing 14. A test tube 15 is movably inserted into the linear bearing 14, and the outer diameter of the test tube 15 is equal to the inner diameter of the linear bearing 14. The test tube 15 can move up and down within the linear bearing 14. A ring plate 16 is fixedly mounted on the top of the linear bearing 14 and is coaxially arranged therewith. The upper end of the test tube 15 has an annular edge. Between the ring plate 16 and the edge, there are multiple springs 17 arranged at intervals around the test tube 15. The upper and lower ends of the springs 17 are fixedly connected to connecting rods 18. The ends of the two connecting rods 18 away from the springs 17 are fixedly connected to the ring plate 16 and the retaining plate 19, respectively. The retaining plate 19 has a retaining groove on the side facing the edge. The retaining plate 19 can be detachably engaged with the edge through the retaining groove.

[0039] Multiple second sliders 7 slide on the linear track 4, and a low-frequency ultrasonic generator 8 is fixedly mounted on the top of each second slider 7. The low-frequency ultrasonic generator 8 can be moved left and right to adjust its position so that it is directly below each test tube 15 in its natural vertical position. The low-frequency ultrasonic generator 8 is connected to a controller.

[0040] The test tube 15 has a removable rubber stopper 20 at its upper opening, such as... Figure 3 and Figure 4As shown, a ring magnet 21 is fixedly provided on the top of the rubber stopper 20, and a hollow tube 22 that is open at both ends is provided inside the rubber stopper 20. The upper end of the hollow tube 22 extends into the space inside the ring magnet 21, and the lower end of the hollow tube 22 is inserted into the test tube 15.

[0041] A plunger 23 that can move up and down is movably inserted inside the hollow tube 22. The inner diameter of the hollow tube 22 is equal to the outer diameter of the plunger 23. A cylindrical magnet 24 is fixedly installed on the top of the plunger 23. The upper end of the cylindrical magnet 24 has the same magnetic pole as the upper end of the ring magnet 21.

[0042] The top of the two uprights 9 is provided with a crossbar 26 that spans all the test tubes 15, as shown in the image. Figure 1 and Figure 2 As shown, the cross frame 26 is a portal frame structure. The top of the left upright 9 is fixedly provided with a fixing sleeve 25. The left end of the cross frame 26 is rotatably inserted into the fixing sleeve 25. The top of the right upright 9 is fixedly provided with a fixing rod 27. The bottom of the right end of the cross frame 26 and the top of the fixing rod 27 are both fixedly provided with positioning magnet blocks 28. The two positioning magnet blocks 28 can attract each other to fix the position of the other end of the cross frame 26.

[0043] The bottom of the crossbeam 26 is equipped with multiple detachable electromagnets 29. In this embodiment, the top of the electromagnets 29 is equipped with a clamp-like structure, which allows the electromagnets 29 to be detachably mounted on the crossbeam 26. The electromagnets 29 are located directly above the ring magnet 21 and the cylindrical magnet 24. All electromagnets 29 are electrically connected to the controller, and all electromagnets 29 are connected in parallel.

[0044] An H-bridge driver chip is connected between the electromagnet 29 and the controller, so that the controller can control the direction of the magnetic poles of the electromagnet 29 after it is energized through the H-bridge driver chip. This circuit is existing technology and will not be described in detail in this embodiment.

[0045] The control panel 1 is equipped with three push switches 3, all of which are electrically connected to the controller.

[0046] One of the push-button switches 3 can control all the electromagnets 29 to change the current direction sequentially from left to right or from right to left through the controller. When changing the current direction, the magnetic poles below the leftmost electromagnet 29 and the rightmost electromagnet 29 are always opposite during the process of changing the current direction.

[0047] Another push switch 3 can control all electromagnets 29 to simultaneously change the current direction through the controller, and when changing the current direction, the magnetic poles below all electromagnets 29 are always the same during the process of changing the current direction.

[0048] The last push switch 3 can control the start or stop of all low-frequency ultrasonic generators 8 via the controller.

[0049] In order to adjust the frequency of the current direction change of electromagnet 29, and thus adjust the swing speed of the mounting plate, such as... Figure 1 and Figure 2 As shown, the control console 1 is equipped with a display screen 2 and an adjustable potentiometer 30. The display screen 2 and the adjustable potentiometer 30 are electrically connected to the controller. The adjustable potentiometer 30 can adjust the frequency of the current change of the electromagnet 29 through the controller. The circuit principle is as follows. Figure 6 As shown. Display screen 2 is used to display the frequency of the current direction change of electromagnet 29.

[0050] Working principle: Before use, select an appropriate number of middle unit plates 12 according to the required number of samples to be mixed. Slide the T-shaped head structure at the end of the edge unit plate 11 into the arc-shaped track groove 1001 of the arc-shaped track 10. Then, the edge unit plate 11 and the middle unit plate 12 are detachably connected in the left-right direction to form a structure as shown in the figure. Figure 1 and Figure 2 The structure shown is then used to fix the first slider 5 onto the linear track 4 by rotating the positioning screw 6 on the first slider 5.

[0051] Insert the test tube 15 into the linear bearing 14, and clamp the clamping plate 19 onto the edge of the test tube 15 through the clamping groove to install the test tube 15 onto the linear bearing 14.

[0052] Adjust the left and right positions of the second slider 7 so that the low-frequency ultrasonic generator 8 on the second slider 7 is directly below each test tube 15 in its natural vertical state.

[0053] Inject the sample liquid to be mixed into each test tube 15. Then, insert the rubber stopper 20 into the upper port of the test tube 15 so that the lower end of the hollow tube 22 is inserted into the sample liquid. Then, insert the plunger 23 into the hollow tube 22. Under the action of hydraulic pressure, the plunger 23 remains stationary in the hollow tube 22, and ensure that the upper end of the cylindrical magnet 24 is above the rubber stopper 20 at this time.

[0054] Select a crossbeam 26 of suitable length, and rotatably insert the left end of the crossbeam 26 into the fixing sleeve 25 at the top of the left upright 9. Fix the other end of the crossbeam 26 to the top of another upright 9 by means of two positioning magnet blocks 28. Install the electromagnet 29 on the crossbeam 26, and position the electromagnet 29 directly above the ring magnet 21 and the cylindrical magnet 24. Electrically connect the electromagnet 29 to the controller, so that all the electromagnets 29 are connected in parallel.

[0055] During mixing: One of the push-button switches 3, in conjunction with the controller, controls all electromagnets 29 to sequentially change the current direction from left to right or from right to left. During this process, it is ensured that the magnetic poles below the leftmost and rightmost electromagnets 29 are always opposite during the current direction change. This allows the two outermost test tubes 15 to be pushed by the attraction or repulsion between the ring magnet 21 and the electromagnets 29 above them, causing the mounting plate to swing back and forth between the two arc-shaped tracks 10 in a seesaw-like motion. Figure 2 As shown, this causes the sample liquid in test tube 15 to be mixed by "shaking left and right".

[0056] Meanwhile, under the attraction or repulsion of the ring magnet 21 and electromagnet 29 above the test tube 15, and with the spring 17 pushing the test tube 15 back and forth, the test tube 15 moves up and down within the linear bearing 14, causing the sample liquid in the test tube 15 to form a "shaking up and down" mixing operation.

[0057] Furthermore, during this process, the cylindrical magnet 24, under the attraction or repulsion of the electromagnet 29, moves back and forth within the hollow tube 22, thereby driving the plunger 23 to move back and forth within the hollow tube 22. This causes the lower end of the hollow tube 22 to draw in and out the sample liquid in the test tube 15, stirring the sample liquid in the test tube 15. Combined with the simultaneous "left-right shaking" and "up-down shaking" mixing operations, the mixing effect of the sample liquid in the test tube 15 is better.

[0058] During this process, the frequency of the current change of the electromagnet 29 can be adjusted by the adjustable potentiometer 30 according to the mixing effect, so as to adjust the swing frequency of the mounting plate, the vertical movement amplitude of the test tube 15, and the vertical movement amplitude of the plunger 23, so as to meet the mixing requirements of sample liquids with different viscosities.

[0059] At the same time, the sample in the test tube 15 above can also be ultrasonically mixed by the low-frequency ultrasonic generator 8 to enhance the mixing effect. When the test tube 15 is swung left and right, the low-frequency ultrasonic generator 8 can directly act on a larger area of ​​the sample liquid in the tilted test tube 15, resulting in a better mixing effect.

[0060] When the viscosity of the sample liquid is low, another push switch 3, in conjunction with the controller, can be used to control all electromagnets 29 to simultaneously change the direction of current, and the magnetic poles of all electromagnets 29 remain the same during the process of changing the direction of current. Figure 1 As shown, the mounting plate is kept stationary, and only the test tube 15 and plunger 23 move back and forth up and down to perform the mixing operation.

[0061] After mixing is complete, remove test tube 15 and send it for testing. Remove rubber stopper 20, hollow tube 22, and plunger 23 for cleaning, disinfection, and storage.

[0062] Example 2: An intelligent mixing device for biochemical sample pretreatment. This example differs from Example 1 in that an H-bridge driver chip is no longer used between the electromagnet 29 and the controller. Instead, a MOSFET driver module (IRF540 or a similar N-channel MOSFET) is used between the electromagnet 29 and the controller, allowing the adjustable potentiometer 30 to adjust the on / off frequency of the electromagnet 29 via the controller. The circuit principle is as follows: Figure 7 As shown. Display screen 2 is used to display the frequency of the electromagnet 29 being switched on and off.

[0063] The control panel 1 has three push-button switches 3, all of which are electrically connected to the controller. One push-button switch 3 can control all the electromagnets 29 to intermittently switch on and off sequentially from left to right or from right to left. The other push-button switch 3 can control all the electromagnets 29 to intermittently switch on and off simultaneously. The other structures are the same as in Embodiment 1.

[0064] Example 3: An intelligent mixing device for biochemical sample pretreatment. This example differs from Example 1 in that the mounting plate is no longer divided into edge unit plate 11 and middle unit plate 12. Other structures are the same as in Example 1.

[0065] Example 4: An intelligent mixing device for biochemical sample pretreatment. This example differs from Example 1 in that the linear bearing 14, spring 17, and clamping plate 19 are no longer installed on the mounting plate, and the test tube 15 is fixedly inserted into the mounting plate. Other structures are the same as in Example 3.

[0066] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims and not by the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

Claims

1. An intelligent mixing device for pretreatment of biochemical samples, characterized in that: The device includes a control console, which contains a controller. The top of the console has two uprights spaced apart on the left and right. Each upright has a vertically arranged arc-shaped track fixed on it. A mounting plate is slidably connected between the two arc-shaped tracks. The mounting plate can swing back and forth between the two arc-shaped tracks. Multiple test tubes with open tops and spaced apart on the left and right are threaded through the mounting plate. Several vertically arranged linear bearings are fixedly mounted on the mounting plate. A ring plate is fixedly mounted on the top of the linear bearing and is coaxially arranged with it. Several springs are fixedly connected to the top of the ring plate and are arranged at intervals around it. A retaining plate is fixedly connected to the top of each spring. A test tube is movably inserted inside the linear bearing. The upper end of the test tube has an annular edge. A slot is opened on the side of the clamping plate facing the edge. The clamping plate can be detachably clamped on the edge through the slot. The outer diameter of the test tube is equal to the inner diameter of the linear bearing. The test tube can move up and down inside the linear bearing. The test tube has a removable rubber stopper at the top opening. A ring magnet is fixed to the top of the rubber stopper. A hollow tube that is open at both ends is inserted inside the rubber stopper. The upper end of the hollow tube extends into the space inside the ring magnet, and the lower end of the hollow tube is inserted into the test tube. A plunger capable of moving up and down is movably inserted inside the hollow tube. The inner diameter of the hollow tube is equal to the outer diameter of the plunger. A cylindrical magnet is fixed on the top of the plunger, and the upper end of the cylindrical magnet has the same magnetic pole as the upper end of the ring magnet. The top of the two uprights is equipped with a crossbar that spans all the test tubes. At the bottom of the crossbar are multiple detachable electromagnets. The electromagnets are located directly above the ring magnet and the cylindrical magnet. All the electromagnets are electrically connected to the controller, and all the electromagnets are connected in parallel. The control panel is equipped with at least two push-button switches, both of which are electrically connected to the controller. One of the push-button switches can control all the electromagnets to intermittently switch on and off or change the direction of current in a direction from left to right or from right to left. When changing the direction of current, the magnetic poles of the leftmost electromagnet and the rightmost electromagnet are always opposite during the process of changing the direction of current. Another push switch can control all electromagnets to intermittently switch on and off or change the direction of current at the same time through the controller, and when changing the direction of current, the magnetic poles below all electromagnets are always the same during the process of changing the direction of current.

2. The intelligent mixing device for biochemical sample pretreatment as described in claim 1, characterized in that: An H-bridge driver chip is connected between the electromagnet and the controller, so that the controller can control the direction of the magnetic poles of the electromagnet after it is energized through the H-bridge driver chip.

3. The intelligent mixing device for biochemical sample pretreatment as described in claim 1, characterized in that: The control panel is equipped with a display screen and an adjustable potentiometer. The display screen and the adjustable potentiometer are electrically connected to the controller. The adjustable potentiometer can adjust the frequency of the electromagnet's current direction change through the controller, and the display screen is used to display the frequency of the electromagnet's current direction change.

4. The intelligent mixing device for biochemical sample pretreatment as described in claim 1, characterized in that: The top of the control panel is equipped with multiple low-frequency ultrasonic generators spaced apart on the left and right. The low-frequency ultrasonic generators are connected to the controller and are located directly below each test tube in its natural vertical position.

5. The intelligent mixing device for biochemical sample pretreatment as described in claim 4, characterized in that: The top of the control panel is fixedly provided with a straight track extending in the left and right direction. Two first sliders are slidably arranged on the straight track with left and right intervals. A positioning screw is threaded through the first slider and connected to it. One end of the positioning screw abuts against the straight track to fix the position of the first slider. The lower ends of the two uprights are fixedly connected to the tops of the two first sliders respectively. The mounting plate includes two edge unit plates and multiple middle unit plates located between the two edge unit plates. The edge unit plates and middle unit plates can be detachably connected in the left and right directions. Each edge unit plate and middle unit plate is equipped with a test tube, and the end of the edge unit plate facing the arc track is slidably connected to the arc track.

6. The intelligent mixing device for biochemical sample pretreatment as described in claim 5, characterized in that: Multiple second sliders are slidably mounted on a linear track, and each low-frequency ultrasonic generator is fixedly mounted on the top of each second slider.

7. The intelligent mixing device for biochemical sample pretreatment as described in claim 5, characterized in that: The crossbeam is a portal frame structure. One end of the crossbeam is rotatably and detachably connected to the top of one of the uprights, and the other end of the crossbeam is detachably connected to the top of another upright.

8. The intelligent mixing device for biochemical sample pretreatment as described in claim 7, characterized in that: Positioning magnets are fixed to the bottom of the other end of the cross frame and the top of the other upright frame. The two positioning magnets can attract each other to fix the position of the other end of the cross frame.

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