Preparation equipment and method of montelukast sodium intermediate

Abstract

The application relates to the technical field of pharmaceutical engineering, in particular to a preparation device and method for a montelukast sodium intermediate; the device comprises an evaporation tower and a base at the bottom of the evaporation tower; a liquid inlet pipe is fixed to the lower position of the inner and outer walls of the evaporation tower; a tower cover is arranged on the upper end of the evaporation tower; the lower end of the tower cover is lower than the upper end of the evaporation tower; an air outlet pipe is arranged at the top of the tower cover, and a discharge pipe is arranged at the bottom of the tower cover; a motor is fixed to the top of the tower cover; a central shaft fixed to the output end of the motor extends to the inside center of the evaporation tower; a spiral plate is fixed to the outer wall of the central shaft; the solution at the bottom of the evaporation tower can be continuously stirred into the spiral gap, so that the solution at the bottom of the evaporation tower spreads on the upper surface of the spiral plate after being heated, the heated area of the solution is increased, the evaporation effect of the solution is improved, and the evaporation crystallization efficiency of the potassium iodide or sodium iodide solution is improved.

Description

TECHNICAL FIELD

[0001] The application relates to the technical field of pharmaceutical engineering, in particular to a preparation device and method for a montelukast sodium intermediate. BACKGROUND

[0002] Montelukast sodium is a highly effective drug widely used in the treatment of asthma and allergic rhinitis, and its preparation process depends on the accurate synthesis of a plurality of intermediates. The preparation of the montelukast sodium intermediate is one of the key links. There are related patent technologies about the preparation method of the montelukast sodium intermediate, for example, the patent number CN103936671B, “Preparation method of montelukast sodium intermediate”, which details the synthesis process of the montelukast sodium intermediate and provides an important reference for industrial production.

[0003] According to the content disclosed in the patent CN103936671B, the preparation of the montelukast sodium intermediate needs to go through a plurality of chemical reactions and post-treatment processes. In the series of reactions for synthesizing the intermediate, the recovery of potassium iodide or sodium iodide is an important auxiliary link, which can not only reduce the waste of raw materials, but also reduce the pressure of three-waste treatment. Specifically, the triethylamine hydroiodide generated in the reaction can obtain a potassium iodide or sodium iodide solution under the action of KOH, NaOH or LiOH, and the crude potassium iodide or sodium iodide can be obtained by evaporation and crystallization. After refining, the crude product can be sold or directly used for the synthesis of o-iodobenzoic acid methyl ester, realizing resource recycling.

[0004] However, in the evaporation and crystallization process of the potassium iodide or sodium iodide solution, the existing equipment and process still have obvious technical limitations: the current evaporation process mostly adopts intermittent operation, that is, after processing a certain amount of solution at a time, the crystallization product needs to be cleaned before the next batch processing, which cannot realize continuous production, seriously restricting the industrial production efficiency. At the same time, the heating mode of the existing evaporation equipment is mostly tank heating, and the contact area of the solution with the heat source is limited, resulting in slow water evaporation rate, which not only prolongs the production cycle, but also increases the energy consumption.

[0005] The above defects make the recovery efficiency of potassium iodide or sodium iodide in the preparation process of the montelukast sodium intermediate be restricted, which indirectly affects the overall production efficiency and cost control of the montelukast sodium intermediate. Therefore, it is of great significance to develop a potassium iodide or sodium iodide solution evaporation and crystallization device and the corresponding preparation method which can realize continuous operation and improve the heating contact area to improve the evaporation efficiency, for optimizing the production process of the montelukast sodium intermediate. SUMMARY

[0006] In order to make up for the deficiencies of the prior art, the present application provides a preparation device and method for a montelukast sodium intermediate, the solution at the bottom of the evaporation tower is continuously pushed into the spiral gap, so that the solution at the bottom of the evaporation tower spreads on the surface of the spiral plate after heating, the heated area of the solution is increased, the evaporation effect of the solution is improved, and the evaporation crystallization efficiency of the potassium iodide or sodium iodide solution is improved.

[0007] The technical scheme adopted by the present application to solve its technical problems is: a preparation device for a montelukast sodium intermediate, comprising an evaporation tower and a base at the bottom of the evaporation tower; a liquid inlet pipe is connected to the lower position of the inner and outer walls of the evaporation tower; a tower cover is sleeved on the upper end of the evaporation tower; the lower end of the tower cover is lower than the upper end of the evaporation tower; an air outlet pipe is arranged at the top of the tower cover, and a discharge pipe is arranged at the bottom of the tower cover; a motor is fixedly connected to the top of the tower cover; a central shaft fixedly connected to the output end of the motor extends to the inside center of the evaporation tower; a spiral plate is fixedly connected to the outer wall of the central shaft; the outer edge of the spiral plate is movably sealed with the inner wall of the evaporation tower; heating wires are fixedly connected to the inside of the spiral plate; a shell pushing device is fixedly connected to the side of the evaporation tower; the top of the shell pushing device is communicated with the tower cover, and the bottom of the shell pushing device is communicated with the lower end of the evaporation tower; the upper end and the lower end of the shell pushing device are rotatably connected to rotating rollers; the two rotating rollers are drivingly connected to a transmission belt; the outer wall of the transmission belt is uniformly connected to pushing plates; the pushing plates can enter the spiral gap of the spiral plate in a circulating manner; the pitch of the spiral plate is greater than the width of the pushing plate.

[0008] Preferably, the outer wall of the pushing plate is fixedly connected to a pushing piece; the pushing piece is perpendicular to the corresponding pushing plate; the pushing piece is adapted to the cross section of the internal movable channel of the shell.

[0009] Preferably, the air outlet pipe is arranged near the upper end of the shell; the inlet end of the liquid inlet pipe is aligned with the lower end of the shell.

[0010] Preferably, a plurality of groups of segmentation strips are uniformly arranged on the upper surface of the spiral plate along the spiral direction; a single group of segmentation strips is arranged at intervals in the radial direction of the central shaft; a plurality of segmentation grooves are arranged on the pushing plate in the length direction; the segmentation grooves on the pushing plate in the evaporation tower are located at the lower position of the pushing plate, and the pushing piece on the pushing plate in the evaporation tower is located at the upper position of the pushing plate.

[0011] Preferably, a notch is arranged on the outer wall of the central shaft near the position of a single group of segmentation strips; the notch is transitionally arranged on the outer wall of the central shaft; a start-stop groove is arranged on the end of the pushing plate in contact with the central shaft; a start-stop plate is slidingly connected in the start-stop groove; the start-stop plate is connected to the bottom of the start-stop groove through a first spring; a start-stop block is arranged on the end of the start-stop plate away from the first spring; a staggered groove corresponding to or staggered from the segmentation groove is arranged on the start-stop plate.

[0012] Preferably, the push plate located in the spiral gap of the spiral plate is provided with a abutting groove at the upper end; the abutting groove is movably connected with an abutting strip; the abutting strip is connected with the bottom of the abutting groove through a second spring; a plurality of abutting strips on the same push plate are distributed along the length direction; the lower end of the spiral plate is fixedly connected with an expansion plate along the spiral direction.

[0013] Preferably, the positions of the abutting strips on the adjacent two push plates abutting against the lower surface of the spiral plate are staggered.

[0014] Preferably, the upper end of the central shaft is provided with a square groove; the square groove is slidably connected with a square rod; the lower end of the square rod is connected with the bottom of the square groove through a third spring; the upper end of the square rod is connected with the output end of the motor; the lower end of the central shaft extends to the inner bottom wall of the evaporation tower and is fixedly connected with a shovel plate along the radial direction.

[0015] Preferably, the inner bottom wall of the evaporation tower is corrugated in the circumferential direction.

[0016] A preparation method of a montelukast sodium intermediate, which is suitable for the preparation equipment of the montelukast sodium intermediate, and the steps of the method are as follows:

[0017] S1: the potassium iodide or sodium iodide solution enters into the bottom of the evaporation tower along the liquid inlet pipe, the heating wire inside the spiral plate is controlled to heat, the motor is started to drive the square rod and the central shaft to rotate, and the central shaft drives the spiral plate to rotate in the process of rotating;

[0018] S2: the spiral plate drives the push plate and the transmission belt to transmit in the process of rotating, the push plate pushes the solution at the bottom of the evaporation tower into the spiral gap of the spiral plate, the push plate pushes the solution along the upper surface of the spiral plate, and the water in the solution is evaporated to leave solid materials;

[0019] S3: the push plate shovels away the solid materials on the upper surface of the spiral plate and flows out from bottom to top, and the solid materials fall into the tower cover and are finally discharged along the discharge pipe;

[0020] S4: part of the steam in the tower cover is discharged along the gas outlet pipe, and the other part is pushed into the push shell by the push piece and flows back to the bottom of the evaporation tower to be preheated by contacting with the solution.

[0021] The beneficial effects of the present application are as follows:

[0022] 1. The solution at the bottom of the evaporation tower is continuously pushed into the spiral gap, so that the solution at the bottom of the evaporation tower spreads on the upper surface of the heated spiral plate, the heated area of the solution is increased, the evaporation effect of the solution is improved, and the evaporation and crystallization efficiency of the potassium iodide or sodium iodide solution is improved.

[0023] 2. The application is because the outer wall of the push plate is vertically fixed with the push piece, so the push piece will push the steam into the push shell with the push plate, the steam will flow from top to bottom along the push shell, and finally backflow to the bottom of the evaporation tower, the steam will contact with the solution at the bottom of the evaporation tower, the heat in the steam will be transferred to the solution at the bottom of the evaporation tower, realizing the preheating of the solution, improving the evaporation crystallization efficiency of the solution.

[0024] 3. The split strip will extrude the solid material at the angle position of the push plate and the upper surface of the spiral plate, the split strip will split the solid material, realizing the crushing of the solid material, avoiding the situation that the solid material is caked, the water vapor inside the material is further evaporated after the material is crushed, improving the evaporation crystallization effect of the material. BRIEF DESCRIPTION OF DRAWINGS

[0025] The application will be further described below in combination with the drawings and embodiments.

[0026] Figure 1 is a perspective view of the equipment of the application;

[0027] Figure 2 is a partially simplified sectional view of the application;

[0028] Figure 3 is a perspective view of the tower cover in the application;

[0029] Figure 4 is a perspective view of the push plate and the transmission belt in the application;

[0030] Figure 5 is a position view of the shovel plate in the application;

[0031] Figure 6 is Figure 2 a detailed sectional view of the middle part;

[0032] Figure 7 is a cooperation schematic view of the push plate and the spiral plate;

[0033] Figure 8 is Figure 7 a sectional view of the push plate;

[0034] Figure 9 is a flow chart of the preparation method of the application.

[0035] In the figure: evaporation tower 1, liquid inlet pipe 11, base 2, tower cover 3, gas outlet pipe 31, discharge pipe 32, motor 33, center shaft 4, missing slot 41, square slot 42, square rod 43, third spring 44, shovel plate 45, spiral plate 5, heating wire 51, split strip 52, abutting slot 53, abutting strip 54, second spring 55, expansion plate 56, push shell 6, rotating roller 61, transmission belt 62, push plate 7, push piece 71, split slot 72, opening and closing slot 73, opening and closing plate 74, first spring 75, opening and closing block 76, staggered slot 77. DETAILED DESCRIPTION

[0036] In order to make the technical means, creative features, purposes and effects of the present application easy to understand, the present application is further described below in conjunction with specific embodiments.

[0037] As shown in Figures 1 to 9 The present application includes the following embodiments:

[0038] Embodiment 1: A preparation device for a montelukast sodium intermediate, comprising an evaporation tower 1 and a base 2 at the bottom of the evaporation tower 1; a liquid inlet pipe 11 is fixed to the lower position of the inner and outer walls of the evaporation tower 1; a tower cover 3 is sleeved on the upper end of the evaporation tower 1; the lower end of the tower cover 3 is lower than the upper end of the evaporation tower 1; an air outlet pipe 31 is arranged at the top of the tower cover 3, and a discharge pipe 32 is arranged at the bottom of the tower cover 3; a motor 33 is fixed to the top of the tower cover 3; a central shaft 4 connected to the output end of the motor 33 extends to the inside center of the evaporation tower 1; a spiral plate 5 is fixed to the outer wall of the central shaft 4; the outer edge of the spiral plate 5 is movably sealed with the inner wall of the evaporation tower 1; heating wires 51 are fixed to the inside of the spiral plate 5; a hull pushing device 6 is fixed to the side of the evaporation tower 1; the top of the hull pushing device 6 is communicated with the tower cover 3, and the bottom of the hull pushing device 6 is communicated with the lower end of the evaporation tower 1; the upper end and the lower end of the hull pushing device 6 are rotatably connected with rotating rollers 61; the upper and lower rotating rollers 61 are drivingly connected with a transmission belt 62; the outer wall of the transmission belt 62 is uniformly connected with pushing plates 7; the pushing plates 7 can cyclically enter the spiral gap of the spiral plate 5; the pitch of the spiral plate 5 is greater than the width of the pushing plates 7.

[0039] The solution to be evaporated enters the evaporation tower 1 along the liquid inlet pipe 11 until the liquid level of the solution is higher than the lower end of the spiral plate 5, the lower end of the transmission belt 62 is lower than the lower end of the spiral plate 5, the upper end of the transmission belt 62 is higher than the upper end of the spiral plate 5, then the motor 33 drives the output end connected central shaft 4 to rotate, the central shaft 4 drives the spiral plate 5 to rotate during rotation, the heating wire 51 in the spiral plate 5 works to heat the spiral plate 5, the lower end of the spiral plate 5 is lower than the liquid level of the solution in the evaporation tower 1, the spiral gap of the spiral plate 5 movably connects the push plate 7, so that the push plate 7 moves along the spiral direction of the spiral plate 5 during the rotation of the spiral plate 5, but since the push plate 7 is limited on the transmission belt 62, the push plate 7 in the spiral gap can only move from bottom to top, the transmission belt 62 drives the two rotating rollers 61 to rotate, so that the push plate 7 in the push shell 6 moves from top to bottom, during the rotation of the spiral plate 5, the push plate 7 enters the spiral gap in circulation with the movement of the transmission belt 62, the push plate 7 moves relative to the spiral plate 5 in the spiral direction, the push plate 7 pushes the solution into the spiral gap, the push plate 7 pushes along the upper surface of the spiral plate 5, the solution pushed by the push plate 7 enters the spiral gap, the push plate 7 has a certain width, the height of the push plate 7 is the width of the push plate 7, the slope of the spiral plate 5 is small, so the push plate 7 can push a certain amount of solution along the upper surface of the spiral plate 5 to move upward, the temperature of the spiral plate 5 rises after being heated by the heating wire 51, the spiral plate 5 transmits heat to the solution flowing on the upper surface of the spiral plate 5, the water in the solution absorbs heat and evaporates into steam, the width of the push plate 7 is smaller than the pitch of the spiral plate 5, so the push plate 7 will not block the spiral gap, and the remaining gap allows the steam to flow from bottom to top along the spiral gap, the steam enters the tower cover 3 along the spiral gap, and finally is discharged along the gas outlet pipe 31, the water in the solution on the upper surface of the spiral plate 5 evaporates into solid material, the solid material is pushed upward by the push plate 7, and falls on the upper end of the spiral plate 5 and falls into the tower cover 3, and finally is discharged along the discharge pipe 32 at the bottom of the tower cover 3, the liquid inlet pipe 11 continuously enters the solution, so that the solution at the bottom of the evaporation tower 1 is continuously replenished, the solution at the bottom of the evaporation tower 1 is continuously pushed into the spiral gap, so that the solution at the bottom of the evaporation tower 1 spreads on the upper surface of the heated spiral plate 5, increases the heated area of the solution, improves the evaporation effect of the solution, and further improves the evaporation and crystallization efficiency of the potassium iodide or sodium iodide solution.

[0040] In example 2, the push plate 7 is movably connected with the push shell 6, and the push plate 7 is movably connected with the transmission belt 62.

[0041] In this embodiment, the gas outlet pipe 31 is arranged near the upper end of the shell 6; the liquid inlet pipe 11 is aligned with the lower end of the shell 6.

[0042] In this embodiment, the transmission belt 62 is a chain (simplified in the figure), and the rotating roller 61 is a sprocket (simplified in the figure), so that the chain can maintain the connection strength with the push plate 7, and the push plate 7 can smoothly push the solution into the spiral gap; the push plate 7 in the evaporation tower 1 moves from bottom to top along with the rotation of the spiral plate 5, and the push plate 7 in the evaporation tower 1 drives the transmission belt 62 to move during the movement from bottom to top, and the transmission belt 62 drives the push plate 7 in the shell 6 to move from top to bottom during the movement, and since the outer wall of the push plate 7 is vertically fixed with the push piece 71, the push piece 71 pushes the steam into the shell 6 along with the push plate 7, the steam flows from top to bottom along the shell 6, and finally flows back to the bottom of the evaporation tower 1, the steam contacts the solution at the bottom of the evaporation tower 1, the heat in the steam is transferred to the solution at the bottom of the evaporation tower 1, the solution is preheated, the evaporation and crystallization efficiency of the solution is improved, and the steam in the evaporation tower 1 flows from bottom to top along the spiral gap; further, the liquid inlet pipe 11 is aligned with the lower end of the shell 6, so that the contact effect of the steam and the solution is improved; the gas outlet pipe 31 is arranged near the upper end of the shell 6, so that the steam is more concentrated and pushed into the shell 6 by the push piece 71.

[0043] In this embodiment, the spiral plate 5 is uniformly provided with a plurality of groups of division strips 52 on the upper surface along the spiral direction; a single group of division strips 52 is arranged in a radial direction on the central shaft 4; the push plate 7 is provided with a plurality of division grooves 72 in the length direction; the division grooves 72 on the push plate 7 in the evaporation tower 1 are located at the lower position of the push plate 7, and the push piece 71 on the push plate 7 in the evaporation tower 1 is located at the upper position of the push plate 7.

[0044] In this embodiment, the outer wall of the central shaft 4 is provided with a missing groove 41 near the position of a single group of division strips 52; the missing groove 41 is transitionally arranged on the outer wall of the central shaft 4; the push plate 7 is provided with an opening and closing groove 73 at the end in contact with the central shaft 4; the opening and closing plate 74 is slidably connected in the opening and closing groove 73; the opening and closing plate 74 is connected to the groove bottom of the opening and closing groove 73 through the first spring 75; the opening and closing plate 74 is provided with an opening and closing block 76 at the end away from the first spring 75; the opening and closing plate 74 is provided with a staggered groove 77 corresponding to or staggered with the division groove 72.

[0045] In the process of the push plate 7 moving relative to the spiral plate 5 along the spiral gap, the push plate 7 pushes the solution onto the upper surface of the spiral plate 5. After the solution is heated and evaporated, solid material is formed and attached to the upper surface of the spiral plate 5. The solid material on the upper surface of the spiral plate 5 is scraped off by the push plate 7. Thus, the solid material is gathered at the position between the side of the push plate 7 facing the material and the upper surface of the spiral plate 5. In the process of the push plate 7 pushing the solid material through the single component partition strip 52, the partition strip 52 extrudes the solid material at the position between the push plate 7 and the upper surface of the spiral plate 5, and divides the solid material to break it, avoiding the agglomeration of the solid material. After the material is broken, the water vapor inside is further evaporated, improving the evaporation and crystallization effect of the material. The partition strip 52 finally passes through the partition groove 72 on the push plate 7. Further, the opening and closing groove 73 and the opening and closing plate 74 are arranged on the push plate 7. When the partition strip 52 does not pass through the push plate 7, the opening and closing block 76 does not enter the range of the missing groove 41, the staggered groove 77 on the opening and closing plate 74 is staggered with the partition groove 72, so that the partition groove 72 is in a closed state, avoiding the leakage of the solution and ensuring the pushing effect of the push plate 7 on the solution on the upper surface of the spiral plate 5. When the partition strip 52 is about to pass through the partition groove 72 on the push plate 7, the opening and closing block 76 enters the range of the missing groove 41 on the outer wall of the central shaft 4. The first spring 75 pushes the opening and closing plate 74 to slide along the opening and closing groove 73. The opening and closing plate 74 drives the staggered groove 77 to correspond to the partition groove 72, so as to open the partition groove 72. Thus, the partition strip 52 can pass through the partition groove 72 after breaking the material. After the partition strip 52 passes through the partition groove 72, the opening and closing block 76 moves out of the corresponding missing groove 41. The opening and closing block 76 is extruded by the outer wall of the central shaft 4 to overcome the first spring 75 to drive the opening and closing plate 74 to slide along the opening and closing groove 73. The opening and closing plate 74 drives the staggered groove 77 to stagger with the partition groove 72 again, so as to close the partition groove 72 on the push plate 7, ensuring the pushing effect of the push plate 7 on the solution and the material and reducing the leakage. The push piece 71 in this embodiment plays a role in shielding and limiting the material.

[0046] In embodiment 4, the push plate 7 located in the spiral gap of the spiral plate 5 is provided with a pressing groove 53 at the upper end. The pressing strip 54 is movably connected in the pressing groove 53. The pressing strip 54 is connected to the bottom of the pressing groove 53 through the second spring 55. A plurality of pressing strips 54 on the same push plate 7 are distributed along the length direction. The lower end of the spiral plate 5 is fixedly connected with the expansion plate 56 along the spiral direction.

[0047] In this embodiment, the positions where the pressing strips 54 on the adjacent two push plates 7 abut against the lower surface of the spiral plate 5 are staggered.

[0048] The expansion plate 56 is fixed to the lower end of the spiral plate 5 along the spiral direction, and is extended. When the opening of the expansion plate 56 is large, the push plate 7 is more easily introduced into the spiral gap. The push plate 7 entering the spiral gap moves upwards along the spiral direction. The second spring 55 at the upper end of the push plate 7 pushes the abutting strip 54 against the lower surface of the spiral plate 5. The reaction force of the second spring 55 acts on the corresponding push plate 7, so that the push plate 7 abuts against the upper surface of the spiral plate 5. The material on the upper surface of the spiral plate 5 can be more completely scraped off, avoiding material residues and improving the crystallization collection effect. The abutting strip 54 moves along the spiral direction during the process of being abutted against the lower surface of the spiral plate 5 by the elastic force of the second spring 55, and moves along with the push plate 7. The abutting strip 54 scrapes the material on the lower surface of the spiral plate 5. The steam can flow away along the gap between the adjacent abutting strips 54 on the push plate 7. The arrangement of the abutting strip 54 can ensure the steam flow and clean and collect the material on the lower surface of the spiral plate 5. The scraping positions of the abutting strips 54 on the adjacent two push plates 7 are different, so that the material on the lower surface of the spiral plate 5 can be scraped.

[0049] In embodiment 5, the upper end of the central shaft 4 is provided with a square groove 42. The square groove 42 is slidably connected with a square rod 43. The lower end of the square rod 43 is connected with the bottom of the square groove 42 through a third spring 44. The upper end of the square rod 43 is connected with the output end of the motor 33. The lower end of the central shaft 4 extends to the inner bottom wall of the evaporation tower 1, and is fixed along the radial direction with a shovel plate 45.

[0050] In this embodiment, the inner bottom wall of the evaporation tower 1 is corrugated in the circumferential direction. The inner bottom wall of the evaporation tower 1 is the upper surface of the base 2.

[0051] The square rod 43 is rotated during the rotation of the motor 33 output shaft, the square rod 43 is rotated during the rotation of the central shaft 4, the central shaft 4 is rotated during the rotation of the spiral plate 5, the central shaft 4 is rotated during the rotation of the shovel plate 45, and the rotating shovel plate 45 can shovel the crystallized material on the inner bottom wall of the evaporation tower 1, so as to avoid the accumulation of the material on the inner bottom wall of the evaporation tower 1; since the inner bottom wall of the evaporation tower 1 is corrugated in the circumferential direction, the shovel plate 45 will sink when moving to the low position of the corrugated surface of the inner bottom wall of the evaporation tower 1, and the shovel plate 45 will move up when moving to the high position of the corrugated surface of the inner bottom wall of the evaporation tower 1, the shovel plate 45 will move up and down repeatedly with the rotation of the central shaft 4, so that the central shaft 4 moves up and down, the central shaft 4 drives the spiral plate 5 to rotate and vibrate up and down, so that the crystallized material on the upper surface of the spiral plate 5 converges towards the position of the included angle between the push plate 7 and the upper surface of the spiral plate 5, thereby opening up space for other solutions, ensuring the contact effect of the upper surface of the spiral plate 5 and the solution, and improving the crystallization efficiency; the material gathered at the included angle between the push plate 7 and the upper surface of the spiral plate 5 is more easily dispersed.

[0052] Embodiment 6: A method for preparing a montelukast sodium intermediate, the method is suitable for the above-mentioned montelukast sodium intermediate preparation device, the steps of the method are as follows:

[0053] S1: The potassium iodide or sodium iodide solution enters the inner bottom of the evaporation tower 1 along the liquid inlet pipe 11, and the heating wire 51 inside the spiral plate 5 is controlled to heat, the square rod 43 and the central shaft 4 are driven to rotate by starting the motor 33, and the central shaft 4 drives the spiral plate 5 to rotate during rotation;

[0054] S2: The spiral plate 5 drives the push plate 7 and the transmission belt 62 to drive during rotation, the push plate 7 pushes the solution at the inner bottom of the evaporation tower 1 into the spiral gap of the spiral plate 5, and the push plate 7 pushes the solution along the upper surface of the spiral plate 5, and the water in the solution is evaporated to leave solid material;

[0055] S3: The push plate 7 shovels away the solid material on the upper surface of the spiral plate 5 and flows out from bottom to top, and the solid material falls into the tower cover 3 and is finally discharged along the discharge pipe 32;

[0056] S4: The steam in the tower cover 3 is discharged along the gas outlet pipe 31, and the other part is pushed into the push shell 6 by the push piece 71 and flows back to the inner bottom of the evaporation tower 1 to be preheated by contacting with the solution.

[0057] In the description of the present application, it should be noted that the terms "center", "longitudinal", "transverse", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like indicate the orientation or positional relationship based on the drawings Figure 1The shown orientation or positional relationship is only for the convenience of describing the present application and simplifying the description, and does not indicate or imply that the indicated device or element must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the scope of protection of the present application. In addition, the terms "first", "second", "third" and the like are only used to distinguish the description and cannot be understood as indicating or implying relative importance.

[0058] The basic principles, main features and advantages of the present application are shown and described above. Those skilled in the art should understand that the present application is not limited by the above examples, and the above examples and descriptions in the specification are only to illustrate the principles of the present application. Without departing from the spirit and scope of the present application, various changes and improvements can be made to the present application, and these changes and improvements all fall within the scope of the claimed present application. The scope of protection of the present application is defined by the appended claims and their equivalents.

Claims

1. An apparatus for preparing a sodium montelukast intermediate, characterized in that: The system includes an evaporation tower and a base at the bottom of the evaporation tower; an inlet pipe is fixedly connected to the lower part of the inner and outer walls of the evaporation tower; a tower cover is fitted over the upper end of the evaporation tower; the lower end of the tower cover is lower than the upper end of the evaporation tower; an outlet pipe is provided at the top of the tower cover, and a discharge pipe is provided at the bottom; a motor is fixedly connected to the top of the tower cover; a central shaft connected to the output end of the motor extends to the center of the inner side of the evaporation tower; a spiral plate is fixedly connected to the outer wall of the central shaft; the outer edge of the spiral plate is movably sealed to the inner wall of the evaporation tower; a heating wire is fixedly connected inside the spiral plate; a diaphragm is fixedly connected to the side of the evaporation tower; the top of the diaphragm is connected to the tower cover, and the bottom is connected to the lower end of the evaporation tower; a rotating roller is rotatably connected to the upper and lower ends of the diaphragm; a transmission belt is driven by the upper and lower rotating rollers; diaphragms are evenly connected to the outer wall of the transmission belt; the diaphragms can circulate into the spiral gap of the spiral plate; the pitch of the spiral plate is greater than the width of the diaphragms.

2. The apparatus for preparing montelukast sodium intermediate according to claim 1, characterized in that: The outer wall of the lever is fixedly connected to the push plate; the push plate is perpendicular to the corresponding lever; the push plate is adapted to the cross section of the moving channel inside the lever housing.

3. The apparatus for preparing montelukast sodium intermediate according to claim 2, characterized in that: The vent pipe is located near the upper end of the dial housing; the inlet end of the liquid inlet pipe is aligned with the lower end of the dial housing.

4. The apparatus for preparing montelukast sodium intermediate according to claim 2, characterized in that: The upper surface of the spiral plate is uniformly provided with multiple sets of dividing strips along the spiral direction; each set of dividing strips is arranged at intervals in the radial direction of the central axis; the push plate is provided with multiple dividing grooves in the length direction; the dividing grooves on the push plate in the evaporation tower are located at the lower position of the push plate, and the push plate on the push plate in the evaporation tower is located at the upper position of the push plate.

5. The apparatus for preparing montelukast sodium intermediate according to claim 4, characterized in that: A notch is provided on the outer wall of the central shaft near the position of the single set of dividing strips; the notch is transitioned to the outer wall of the central shaft; an opening and closing groove is provided at the end of the lever that contacts the central shaft; an opening and closing plate is slidably connected in the opening and closing groove; the opening and closing plate is connected to the bottom of the opening and closing groove by a first spring; an opening and closing block is provided at the end of the opening and closing plate away from the first spring; and staggered grooves corresponding to or offset from the dividing grooves are provided on the opening and closing plate.

6. The apparatus for preparing montelukast sodium intermediate according to claim 2, characterized in that: A pressing groove is provided at the upper end of the lever plate located in the spiral gap of the spiral plate; a pressing bar is movably connected in the pressing groove; the pressing bar is connected to the bottom of the pressing groove by a second spring; multiple pressing bars on the same lever plate are distributed at intervals along the length direction; an expansion plate is fixedly connected to the lower end of the spiral plate along the spiral direction.

7. The apparatus for preparing a sodium montelukast intermediate according to claim 6, characterized in that: The positions of the clamping strips on the two adjacent dial plates against the lower surface of the spiral plate are staggered.

8. The apparatus for preparing a sodium montelukast intermediate according to claim 4, characterized in that: A square groove is provided at the upper end of the central shaft; a square rod is slidably connected in the square groove; the lower end of the square rod is connected to the bottom of the square groove by a third spring; the upper end of the square rod is connected to the motor output end; the lower end of the central shaft extends to the bottom wall of the evaporation tower and is fixed to a shovel plate radially.

9. The apparatus for preparing montelukast sodium intermediate according to claim 8, characterized in that: The bottom wall of the evaporation tower is corrugated in the circumferential direction.

10. A method for preparing a sodium montelukast intermediate, the method being applicable to the preparation equipment for the sodium montelukast intermediate according to any one of claims 1-9, characterized in that: The steps of this method are as follows: S1: Potassium iodide or sodium iodide solution enters the bottom of the evaporation tower through the inlet pipe and controls the heating wire inside the spiral plate to heat it. The motor is started to drive the square rod and the central shaft to rotate. During the rotation of the central shaft, the spiral plate will rotate. S2: During the rotation of the spiral plate, it will drive the swash plate and the transmission belt to drive the solution. The swash plate pushes the solution at the bottom of the evaporation tower into the spiral gap of the spiral plate. The swash plate will push the solution along the upper surface of the spiral plate. The water in the solution is evaporated, leaving solid material. S3: The scooping plate removes the solid material on the upper surface of the spiral plate and flows out from bottom to top. The solid material will fall into the tower cover and finally be discharged along the discharge pipe. S4: Part of the steam inside the tower is discharged along the outlet pipe, and the other part is pushed into the shell by the pusher plate and flows back to the bottom of the evaporation tower to contact the solution for preheating.

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