Chest surgery tumor tissue sample storage and analysis detection device

Abstract

The invention relates to the technical field of pathological detection of tumor tissue samples, and provides a storage, analysis and detection device for thoracic surgery tumor tissue samples. Comprising a sealing shell, a tray module, a digital pathological scanner, a sample storage vessel, a lifting transfer module, a static sealing assembly, a sample angle adjusting module, a circulating refrigeration module and an inert gas circulating conveying module, through the design of integrating a sealing environment, mechanical linkage sealing control, multifunctional lifting transfer, integrated sample adjustment and full-process automation, full-process inert gas protection, automatic transfer with zero manual contact, accurate multi-angle detection and partitioned environment isolation are realized through multiple innovative designs. The problems of large occupied area, low detection efficiency, insufficient sealing and repeated manual operation of split design in the prior art are solved, and the device has the characteristics of preventing sample oxidation, keeping sample activity and improving detection precision and efficiency.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of tumor tissue sample pathological detection, in particular to a thoracic surgery tumor tissue sample storage and analysis detection device. BACKGROUND

[0002] The thoracic surgery tumor tissue sample storage and analysis detection device is generally a split type device, including a refrigerated storage device, a pretreatment device and a digital pathology scanner. In actual operation, the samples stored in the refrigerated storage device need to be manually transferred to the pretreatment device, the user of the pretreatment device needs to thaw and prevent contamination of the samples, and then the samples need to be manually transferred to the digital pathology scanner for sample detection.

[0003] After searching, the existing publication number CN120064625B discloses a solid tumor immune microenvironment detection and analysis device, which includes a detection mechanism for contacting or puncturing part of the tumor sample to upload data for the operator to analyze, a transportation and cleaning mechanism with integrated transportation, cleaning and adjustment functions for cleaning the two sides of the sample during transportation and adapting to different sample sizes, a clamping and turning mechanism for clamping and turning the sample to expose the cleaning surface, a collection assembly for detachable recovery of falling impurities, and a wiping assembly for cleaning the detection area of the detection mechanism after detection to prevent residual substances from affecting the subsequent detection results. The transportation and cleaning mechanism of the invention can automatically clean the impurities on the outside of the tumor sample during transportation, and can adjust to different sample sizes, improving the accuracy of subsequent detection.

[0004] The existing tissue sample storage and analysis detection device still has the following defects: (1) the storage and analysis detection device with split type design needs manual sample transfer during detection, especially when multiple samples need to be detected multiple times, which requires multiple manual operations, resulting in large floor area and low detection efficiency; (2) the sample is easily exposed to the air during transfer, leading to oxidation, and the temperature fluctuates greatly, causing sample degradation and ice crystal damage. SUMMARY

[0005] The purpose of the present application is to provide a thoracic surgery tumor tissue sample storage and analysis detection device, which integrates a sealed environment, mechanical linkage sealing control, multifunctional lifting transfer and integrated sample adjustment and full-process automation design, realizes full-process inert gas protection, zero manual contact automatic transfer, precise multi-angle detection and partitioned environment isolation through multiple innovative designs. The problems of large floor area, low detection efficiency, insufficient sealing and multiple manual operations of the split type design of the prior art are solved.

[0006] To achieve the above object, the present application provides the following technical scheme, a thoracic surgery tumor tissue sample storage and analysis detection device, including sealed shell, digital pathology scanner, circulating refrigeration module and inert gas circulation and delivery module, the inside of the sealed shell is from top to bottom in turn detection area, pretreatment area and storage area, the scanner, circulating refrigeration module and inert gas circulation and delivery module are arranged in detection area, storage area and pretreatment area respectively, still include: The tray module in sliding contact with the inner wall of the sealed shell, the tray module includes a first drive, a storage tray, a detection tray and an axial rod, the axial rod is fixedly connected between the storage tray and the detection tray, and the first drive is used to control the rotation of the storage tray and the detection tray. The sample storage dish is arranged on the surface of the storage tray. The sample angle adjusting module is arranged on the surface of the detection tray. The static sealing assembly includes a sealing partition, an axial guide rail, a hollow column and a sealing cover, the sealed shell is fixedly connected with the hollow column, the sealing partition is fixedly connected on the surface of the hollow column, the inert gas circulation and delivery module is fixedly arranged on the upper surface of the sealing partition, the sealing cover is fixedly arranged between the hollow column and the sealing partition, the inert gas circulation and delivery module is in communication with the sealing cover, and the axial guide rail is arranged on the surface of the hollow column. The lifting and transferring module includes a lifting assembly and an adsorption assembly, the lifting assembly penetrates through the hollow column, the adsorption assembly is slidingly connected in the axial guide rail, the lifting assembly is used to control the lifting movement of the adsorption assembly, and the adsorption assembly can enter below the storage tray.

[0007] As a further scheme of the present application, the sample angle adjusting module includes a horizontal rotating ring, an inclination adjusting ring, a rotating tube, a transmission gear and an elastic limiting piece, the horizontal rotating ring is rotationally arranged on the surface of the detection tray, the inclination adjusting ring is fixedly provided with the elastic limiting piece and the rotating tube on the inner and outer sides respectively, the rotating tube penetrates through the surface of the horizontal rotating ring, and the transmission gear is fixedly arranged on the surface of the rotating tube.

[0008] The present application has the advantages that: the thoracic surgery tumor sample storage, transfer and detection are fully automated by the design of dynamic sealing and transfer mechanical linkage, structure reuse, intelligent positioning of the sample angle adjusting module and modular multi-group tray efficient batch detection, the problems of sample oxidation during sample transfer, insufficient positioning accuracy leading to missed diagnosis of micro lesions, complex structure system and cumbersome operation process are solved, and the present application has the characteristics of preventing sample oxidation, maintaining sample activity, improving detection accuracy and efficiency. BRIEF DESCRIPTION OF DRAWINGS

[0009] Figure 1 It is a plan view of the present application.

[0010] Figure 2 isometric view of the sample storage tray of the present invention.

[0011] Figure 3 isometric view of the sample storage tray of the present invention.

[0012] Figure 4 isometric view of the sample angle adjustment module of the present invention.

[0013] Figure 5 isometric view of the tray module of the present invention.

[0014] Figure 6 isometric view of the tray module and the angle adjustment module of the present invention.

[0015] Figure 7 isometric view of the lift transfer module of the present invention.

[0016] Figure 8 isometric view of the lift assembly of the present invention.

[0017] Figure 9 isometric view of the suction assembly of the present invention.

[0018] Figure 10 isometric view of the static seal assembly of the present invention.

[0019] Figure 11 isometric view of the dynamic seal assembly of the present invention.

[0020] Figure 12 isometric view of the internal parts of the present invention.

[0021] Figure 13 cross-sectional view of the internal parts of the present invention.

[0022] Figure 14 isometric view of the present invention Figure 13 close-up view of a at a in the present invention.

[0023] Figure 15 isometric view of the present invention Figure 1 close-up view of b at b in the present invention.

[0024] Figure 16 isometric view of the present invention.

[0025] Reference numerals: 1 - sealed housing, 11 - detection area, 12 - storage area, 13 - pre-treatment area; 2 - digital pathology scanner; 3 - sample storage tray, 31 - axial slot; 4-sample angle adjusting module, 41-horizontal rotation ring, 42-inclination angle adjusting ring, 421-rotation tube, 422-transmission gear, 423-elastic limiting piece; 5-tray module, 51-first driving piece, 52-storage tray, 521-storage groove, 53-detection tray, 531-first toothed rail, 532-second toothed rail, 54-axial rod, 55-sealing ring; 6-lifting and transferring module, 61-lifting assembly, 611-first winding part, 612-second winding part, 613-pulling belt, 614-rigid piece, 6141-circular block, 6142-fixing rod, 6143-semi-circular block, 6144-toothed groove, 62-suction assembly, 621-semi-cylindrical column, 6211-rectangular block, 622-base plate, 623-suction disc, 624-spherical universal joint, 625-central tube, 626-second driving piece; 7-static sealing assembly, 71-sealing partition plate, 72-hollow column, 73-sealing cover, 74-axial guide rail, 75-limiting frame, 76-supporting frame; 8-inert gas circulation and delivery module, 81-gas discharge pipe, 82-gas circulation pipe; 9-dynamic sealing assembly, 91-sealing plate, 92-opening, 93-transmission gear set, 94-third toothed rail; 10-circulating refrigeration module. DETAILED DESCRIPTION

[0026] In order to make the purpose, technical scheme and advantages of the present application clearer, the present application will be further described in detail below in combination with the drawings and specific embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0027] The specific implementation of the present application is described in detail below in combination with specific embodiments.

[0028] Please refer to Figures 1 to 16 In an embodiment of the present application, a thoracic surgical tumor tissue sample storage and analysis detection device includes a sealed shell 1, a digital pathology scanner 2, a circulating refrigeration module 10 and an inert gas circulation and delivery module 8. The inner side of the sealed shell 1 is sequentially provided with a detection area 11, a pretreatment area 13 and a storage area 12 from top to bottom. The scanner, the circulating refrigeration module 10 and the inert gas circulation and delivery module 8 are respectively arranged in the detection area 11, the storage area 12 and the pretreatment area 13. The device further includes: A tray module 5 in sliding contact with the inner wall of the sealed shell 1. The tray module 5 includes a first driving piece 51, a storage tray 52, a detection tray 53 and an axial rod 54. The axial rod 54 is fixedly connected between the storage tray 52 and the detection tray 53. The first driving piece 51 is used to control the rotation of the storage tray 52 and the detection tray 53. The sample storage dish 3 is arranged on the surface of the storage tray 52. The sample angle adjusting module 4 is arranged on the surface of the detection tray 53. The static sealing assembly 7 comprises a sealing partition plate 71, an axial guide rail 74, a support frame 76, a hollow column 72 and a sealing cover 73, the sealing shell 1 is fixedly connected with the hollow column 72, the surface of the hollow column 72 is fixedly connected with the sealing partition plate 71, the inert gas circulating and conveying module 8 is fixedly arranged on the upper surface of the sealing partition plate 71, the sealing cover 73 is fixedly arranged between the hollow column 72 and the sealing partition plate 71, the inert gas circulating and conveying module 8 is fixedly connected with a gas discharge pipe 81 and a gas circulation pipe 82, the gas discharge pipe 81 is fixedly connected with the top of the sealing cover 73, the gas circulation pipe 82 is provided with a gas sensor (for monitoring the inert gas component in the gas), the surface of the hollow column 72 is provided with the axial guide rail 74, the support frame 76 is fixedly arranged on the top of the hollow column 72, and the first driving member 51 is fixedly arranged on the surface of the support frame 76. The lifting and transferring module 6 comprises a lifting assembly 61 and an adsorption assembly 62, the lifting assembly 61 penetrates through the hollow column 72, and the adsorption assembly 62 is slidingly connected in the axial guide rail 74, the lifting assembly 61 is used for controlling the lifting and lowering movement of the adsorption assembly 62, and the adsorption assembly 62 can enter below the storage tray 52.

[0029] Please refer to Figures 7 to 9 Further, the adsorption assembly 62 comprises a base plate 622, an adsorption disc 623, a spherical universal joint 624, a central pipe 625 and a second driving member 626, the base plate 622 is slidingly connected in the axial guide rail 74, the second driving member 626 and the central pipe 625 are both connected on the surface of the base plate 622, the adsorption disc 623 is arranged between the adsorption disc 623 and the central pipe 625, and the second driving member 626 is used for controlling the rotation of the adsorption disc 623 and the central pipe 625, the adsorption disc 623 fixes the sample storage dish 3 in a mode of vacuum adsorption, precise positioning is achieved by using a displacement sensor or an infrared sensor, zero mechanical contact transfer is achieved, and sample damage is avoided.

[0030] Please refer to Figures 7 to 13 Further, the lifting assembly 61 comprises a first winding part 611, a second winding part 612, a traction belt 613 and a rigid member 614, the first winding part 611 and the second winding part 612 are both fixedly connected with the sealing shell 1, one end of each of the two groups of traction belts 613 is wound in the first winding part 611 and the second winding part 612 respectively, and the rigid member 614 is fixedly connected between the two groups of traction belts 613.

[0031] Please refer to Figures 7 to 13Further, the tray module 5 further comprises a storage groove 521 and a sealing ring 55, the surface of the storage tray 52 is provided with the storage groove 521, the sample storage dish 3 can be placed in the storage groove 521, the adsorption assembly 62 can penetrate the storage groove 521, and the sealing ring 55 is fixedly arranged on the surface of the axial rod 54 and is slidingly connected between the sealing partition plate 71 and the sealing shell 1.

[0032] In the embodiment of the application, when the sample storage dish 3 rises into the sealing cover 73, the inert gas is injected into the sealing cover 73 from the top discharge pipe. At the same time, the base plate 622 and the circular block 6141 are in sliding contact with the inner wall of the sealing cover 73 and the hollow column 72, forming a dynamic seal to prevent gas leakage. When the sample rises to the detection area 11 and the gas sensor detects the inert gas, the circulation system is started, and the inert gas in the detection area 11 is extracted through the gas circulation pipe 82 for recycling, realizing closed-loop circulation of the inert gas and greatly reducing gas consumption.

[0033] Please refer to Figures 4 to 6 In another embodiment of the application, the sample angle adjusting module 4 comprises a horizontal rotating ring 41, an inclination adjusting ring 42, a rotating pipe 421, a transmission gear 422 and an elastic limiting piece 423, the horizontal rotating ring 41 is rotatably arranged on the surface of the detection tray 53, the inclination adjusting ring 42 is fixedly arranged with the elastic limiting piece 423 and the rotating pipe 421 on the inner and outer sides respectively, the rotating pipe 421 penetrates the surface of the horizontal rotating ring 41, and the transmission gear 422 is fixedly arranged on the surface of the rotating pipe 421.

[0034] Please refer to Figure 4 and Figure 15 Further, the outer side of the sample storage dish 3 is provided with a plurality of axial grooves 31, and the elastic limiting piece 423 can enter the axial groove 31.

[0035] Please refer to Figure 6 Further, the tray module 5 further comprises a first toothed rail 531 and a second toothed rail 532, the upper surface of the detection tray 53 is fixedly provided with the first toothed rail 531, the lower surface of the detection tray 53 is provided with a plurality of second toothed rails 532, the first driving member 51 is in transmission connection with the first toothed rail 531, and the transmission gear 422 is in transmission connection with the second toothed rail 532.

[0036] Please refer to Figure 16 Further, the surface of the sealing shell 1 is provided with a taking and placing opening and a sealing cover corresponding to the positions of the detection area 11 and the storage area 12, so as to facilitate a user to take and place the sample storage dish 3.

[0037] In the embodiment of the present application, the axial groove 31 is a blind groove (or a non-axial through groove), when the elastic limiting piece 423 enters the axial groove 31, the elastic limiting piece 423 can play a role of axially supporting the sample storage dish 3, the elastic limiting piece 423 comprises a wedge-shaped block, a spring, a movable pin and a pressure sensor, the wedge-shaped block is fixedly arranged at one end of the movable pin, the movable pin is connected in the rotating tube 421, the spring is connected between the wedge-shaped block and the movable pin, the pressure sensor is embedded at the other end of the movable pin, the second driving piece 626 is used to control the rotation of the adsorption disc 623, and the automatic positioning is realized through the cooperation of the elastic limiting piece 423 and the axial groove 31 on the sample storage dish 3. When the axial groove 31 is aligned with the elastic limiting piece 423, the elastic limiting piece 423 is popped into the groove, and self-locking is formed to prevent the sample from falling. At the same time, the rotation of the horizontal rotating ring 41 is meshed with the second gear rail 532 through the transmission gear 422, so that the inclination adjusting ring 42 is swung, inclination adjustment of ± 15 degrees is realized, and the functions of sample storage, transfer, installation and angle adjustment can be realized at the same time by using the adsorption disc 623.

[0038] The whole adjustment process is automatic, and the positioning accuracy (error < ± 0.1 mm) is ensured through mechanical self-locking, the micro-lesion positioning problem is solved, and the detection rate is improved.

[0039] Please refer to Figures 7 to 9 、 Figure 13 、 Figure 14 In another embodiment of the present application, the rigid piece 614 comprises a circular block 6141, a fixed rod 6142, a semicircular block 6143 and a tooth groove 6144, the fixed rod 6142 is fixedly connected between the circular block 6141 and the semicircular block 6143, the circular block 6141 and the semicircular block 6143 are fixedly connected with two groups of traction belts 613 respectively, and the surface of the fixed rod 6142 is provided with the tooth groove 6144.

[0040] Please refer to Figures 7 to 9 、 Figure 13 、 Figure 14 Further, the adsorption assembly 62 further comprises a semicircular column 621 and a rectangular block 6211, the base plate 622 is fixedly connected with the semicircular column 621, the rectangular block 6211 is fixedly arranged on the plane side of the semicircular column 621, the plane side of the rectangular block 6211 and the semicircular column 621 is in sliding contact with the surface of the fixed rod 6142, the semicircular block 6143 can be in contact with the lower side of the semicircular column 621, and the arc side of the circular block 6141 and the semicircular column 621 is in sliding contact with the inner side of the hollow column 72.

[0041] Please refer to Figures 11 to 13Further, the dynamic sealing assembly 9 comprises a sealing plate 91, an opening 92, a transmission gear set 93 and a third toothed track 94, the sealing plate 91 is movably sleeved on the surface of the hollow column 72, the surface of the sealing plate 91 is in contact with the sealing plate 71 below, the surface of the sealing plate 91 is provided with the opening 92 and the third toothed track 94, the transmission gear set 93 penetrates through the hollow column 72, the gear slot 6144 is in transmission connection with one side of the transmission gear set 93, and the third toothed track 94 is in transmission connection with the other side of the transmission gear set 93.

[0042] In the embodiment of the application, when the rigid piece 614 rises, the sealing plate 91 is rotated by 90 degrees through cooperation of the gear slot 6144 and the transmission gear set 93, so that the opening 92 is moved to below the sealing cover 73. The action is synchronized with sample lifting, and the rapid opening of the transfer channel is realized, and the action is completed before the semicircular block 6143 contacts the semicircular column 621, so that cold and heat exchange is avoided. After sample detection is completed, the adsorption disc 623 is lowered and reset, and then the sealing plate 91 is rotated again to seal. The whole process is completed in an inert gas environment, so that the sample is always protected by inert gas during the transfer process. Since the transfer speed is fast and the sealing is rapid, the sample is exposed for a very short time, the temperature fluctuation is small, and sample degradation and oxidation are effectively prevented. The lifting assembly 61 is used for lifting the sample and controlling the opening and closing of the sealing plate 91 through the gear slot 6144 and the gear transmission, so that the number of independent driving components is reduced. The base plate 622 and the circular block 6141 form sliding sealing with the sealing cover 73 and the hollow column 72 during the transfer process, so that inert gas leakage is prevented. After the sample is lifted, the lifting assembly 61 serves as a sealing cover to prevent cold air from entering the detection area 11. The above multiplexing structure reduces the number of parts, reduces the failure rate, and simplifies the control logic and the device size.

[0043] In the initial state, the sample storage dish 3 with the tissue sample is placed in the placement groove 521 on the surface of the storage tray 52, the adsorption assembly 62 is overlapped on the surface of the limiting frame 75 (or located below the storage tray 52), and the sealing plate 91 is sealed below the sealing cover 73 (or the opening 92 is separated from below the sealing cover 73, which is used to prevent cold air in the storage area 12 from entering the detection area 11 through the sealing cover 73).

[0044] The steps of transferring the sample storage dish 3 to the detection area 11 for detection include: S100, the second winding part 612 and the traction belt 613 are used to control the rigid piece 614 to rise, before the semicircular block 6143 contacts the bottom of the semicircular column 621, the fixed rod 6142 of the rising movement drives the sealing plate 91 to rotate by 90 degrees through transmission connection between the gear slot 6144 and the transmission gear set 93, so as to move the opening 92 to below the sealing cover 73; S200, when the semicircular block 6143 contacts the bottom of the semicircular column 621, the rigid piece 614 drives the adsorption assembly 62 to rise synchronously through the semicircular column 621, and the adsorption disc 623 adsorbs the sample storage dish 3 when it contacts the bottom of the sample storage dish 3 (the position coordinates of the sample storage dish 3 are accurately monitored through the displacement sensor or infrared sensor on the surface of the base plate 622), thus, the lifting assembly 61 drives the sample storage dish 3 to enter the sealed cover 73 through the opening 92 through the adsorption disc 623; S300, the inert gas circulation conveying module 8 discharges inert gas into the sealed cover 73 from the top through the gas discharge pipe 81, because the base plate 622 and the circular block 6141 are in sliding contact with the inner wall of the sealed cover 73 and the hollow column 72 respectively, thus, the inert gas can be prevented from leaking from below the sealed cover 73 and the hollow column 72, so as to ensure that the sample is in the package or protection of inert gas during the sample transfer process, the inert gas filled in the sealed cover 73 can prevent the tissue sample from being oxidized, and on the other hand, the lifting assembly 61 can be used to temporarily store the sample in the sealed cover 73 for thawing, preventing the sample tissue from being contaminated, with the rising of the sample storage dish 3, the inert gas in the sealed cover 73 will all enter the detection area 11, when the gas sensor at the end of the gas circulation pipe 82 detects the inert gas, the inert gas circulation conveying module 8 extracts the air in the detection area 11 through the gas circulation pipe 82 for circulation treatment; S400, when the sample storage dish 3 is transferred to the sample angle adjusting module 4 by using the lifting assembly 61, the base plate 622 and the circular block 6141 seal the sealed cover 73 and the hollow column 72 from the top, preventing the cold air in the storage area 12 from entering the detection area 11, the adsorption disc 623 and the sample storage dish 3 are rotated by using the second driving piece 626, when the wedge-shaped block does not enter the axial groove 31 of the sample storage dish 3, the wedge-shaped block is pressed in the elastic contraction state by the sample storage dish 3, when the axial groove 31 is aligned with the wedge-shaped block, the wedge-shaped block enters the axial groove 31 under the action of the spring elastic force, the pressure sensor is triggered, and the second driving piece 626 is controlled to be closed, the wedge-shaped block can prevent the sample storage dish 3 from falling on one hand, and on the other hand, the limiting of the wedge-shaped block can drive the sample angle adjusting module 4 to rotate when the sample storage dish 3 rotates; S500, when it is needed to adjust the horizontal position and the angle of inclination of the tissue sample during the detection process by the digital pathology scanner 2, the second driving member 626 is used to control the rotation of the adsorption disc 623 and the sample storage dish 3, based on the rotation method of the sample angle adjustment module 4 in step S400, when the horizontal rotating ring 41 follows the horizontal rotation of the adsorption disc 623 and the sample storage dish 3, the transmission connection between the transmission gear 422 and the second toothed rail 532 can drive the angle adjustment ring 42, the elastic limiting piece 423, the adsorption disc 623 (the structure of the spherical universal joint 624 allows the adsorption disc 623 to swing synchronously) and the sample storage dish 3 to swing ± 15 degrees around the rotating tube 421 as the axis, and the angle sensor on the rotating tube 421 is used to monitor the angle of inclination of the sample storage dish 3 in real time; S600, after the detection is completed, the adsorption disc 623 is used to release the sample storage dish 3, the adsorption disc 623 is controlled to descend and reset by the lifting assembly 61, when the base plate 622 is overlapped on the surface of the limiting frame 75, the first winding part 611 continues to control the rigid piece 614 to descend through the traction belt 613, based on the principle of controlling the rotation of the sealing plate 91 in step S100, the sealing plate 91 can seal the sealing cover 73 again; S700, when it is needed to detect the tissue sample in another sample storage dish 3, the storage tray 52 and the detection tray 53 are synchronously rotated by the first driving member 51, and the operation based on the methods in steps S100-S600 can automatically complete the transfer, pretreatment, angle adjustment and detection of the tissue sample.

[0045] In summary, the design of the application utilizes the mechanical linkage of dynamic sealing and transfer, structural reuse, intelligent positioning of the sample angle adjustment module 4 and modular multi-group tray high-efficiency batch detection, which automates the whole process of storage, transfer and detection of thoracic surgery tumor samples, solves the problems of sample oxidation, insufficient positioning accuracy leading to missed diagnosis of micro lesions, complex structure system and cumbersome operation process, and has the characteristics of preventing sample oxidation, maintaining sample activity, improving detection accuracy and efficiency.

[0046] For those skilled in the art, although several embodiments and examples of the application are described, these embodiments and examples are presented as examples and are not intended to limit the scope of the application. These new embodiments can be implemented in other various ways, and various omissions, substitutions, changes can be made without departing from the scope of the application.

[0047] In addition, it should be understood that although the present specification is described in terms of embodiments, not every embodiment contains only one independent technical solution, and the description manner of the specification is only for the sake of clarity, those skilled in the art should consider the specification as a whole, and the technical solutions in each example can be appropriately combined to form other embodiments that those skilled in the art can understand.

Claims

1. A thoracic surgical tumor tissue sample storage and analysis detection device, comprising a sealed shell (1), a digital pathology scanner (2), a circulating refrigeration module (10) and an inert gas circulation and delivery module (8), the inside of the sealed shell (1) is sequentially provided with a detection area (11), a pretreatment area (13) and a storage area (12) from top to bottom, and the scanner, the circulating refrigeration module (10) and the inert gas circulation and delivery module (8) are arranged in the detection area (11), the storage area (12) and the pretreatment area (13) respectively, characterized in that, Also include: The tray module (5) in sliding contact with the inner wall of the sealed shell (1), the tray module (5) comprises a first driving element (51), a storage tray (52), a detection tray (53) and an axial rod (54), the axial rod (54) is fixedly connected between the storage tray (52) and the detection tray (53), the first driving element (51) is used for controlling the rotation of the storage tray (52) and the detection tray (53); The sample storage dish (3) is arranged on the surface of the storage tray (52); The sample angle adjusting module (4) is arranged on the surface of the detection tray (53); The static sealing assembly (7) comprises a sealing partition (71), an axial guide rail (74), a hollow column (72) and a sealing cover (73), the sealing shell (1) is fixedly connected with the hollow column (72), the surface of the hollow column (72) is fixedly connected with the sealing partition (71), the inert gas circulation conveying module (8) is fixedly arranged on the upper surface of the sealing partition (71), the sealing cover (73) is fixedly arranged between the hollow column (72) and the sealing partition (71), the inert gas circulation conveying module (8) is communicated with the sealing cover (73), and the surface of the hollow column (72) is provided with the axial guide rail (74); The lifting transfer module (6) comprises a lifting assembly (61) and an adsorption assembly (62), the lifting assembly (61) penetrates through the hollow column (72), the adsorption assembly (62) is slidingly connected in the axial guide rail (74), the lifting assembly (61) is used for controlling the lifting motion of the adsorption assembly (62), and the adsorption assembly (62) can enter below the storage tray (52).

2. The thoracic surgical tumor tissue sample storage and analysis device of claim 1, wherein, The sample angle adjusting module (4) comprises a horizontal rotating ring (41), an inclination adjusting ring (42), a rotating pipe (421), a transmission gear (422) and an elastic limiting piece (423), the horizontal rotating ring (41) is rotatably arranged on the surface of the detection tray (53), the inclination adjusting ring (42) is fixedly provided with the elastic limiting piece (423) and the rotating pipe (421) on the inner and outer sides, respectively, the rotating pipe (421) penetrates through the surface of the horizontal rotating ring (41), and the transmission gear (422) is fixedly arranged on the surface of the rotating pipe (421).

3. The thoracic surgical tumor tissue sample storage and analysis device of claim 2, wherein, The elastic limiting piece (423) can enter the axial groove (31).

4. The thoracic surgical tumor tissue sample storage and analysis device of claim 3, wherein, The tray module (5) further comprises a first toothed rail (531) and a second toothed rail (532), the upper surface of the detection tray (53) is fixedly provided with the first toothed rail (531), the lower surface of the detection tray (53) is provided with a plurality of second toothed rails (532), the first driving element (51) is in transmission connection with the first toothed rail (531), and the transmission gear (422) is in transmission connection with the second toothed rail (532).

5. The device for storing and analyzing thoracic surgical tumor tissue samples according to claim 4, characterized in that, The adsorption assembly (62) comprises a base plate (622), an adsorption disc (623), a spherical universal joint (624), a central pipe (625) and a second driving element (626), the base plate (622) is slidingly connected in the axial guide rail (74), the second driving element (626) and the central pipe (625) are both connected on the surface of the base plate (622), the adsorption disc (623) is arranged between the central pipe (625), and the second driving element (626) is used for controlling the rotation of the adsorption disc (623) and the central pipe (625).

6. The thoracic surgical tumor tissue sample storage and analysis device of claim 5, wherein, The lifting assembly (61) comprises a first winding part (611), a second winding part (612), traction belts (613) and a rigid element (614), the first winding part (611) and the second winding part (612) are both fixedly connected with the sealing shell (1), one ends of the two groups of traction belts (613) are respectively wound in the first winding part (611) and the second winding part (612), and the rigid element (614) is fixedly connected between the two groups of traction belts (613).

7. The thoracic surgical tumor tissue sample storage and analysis device of claim 6, wherein, The rigid element (614) comprises a circular block (6141), a fixed rod (6142), a semicircular block (6143) and a gear slot (6144), the fixed rod (6142) is fixedly connected between the circular block (6141) and the semicircular block (6143), the circular block (6141) and the semicircular block (6143) are respectively fixedly connected with the two groups of traction belts (613), and the surface of the fixed rod (6142) is provided with the gear slot (6144).

8. The thoracic surgical tumor tissue sample storage and analysis device of claim 7, wherein, The adsorption assembly (62) further comprises a semicylinder (621) and a rectangular block (6211), the base plate (622) is fixedly connected with the semicylinder (621), the rectangular block (6211) is fixedly arranged on the planar side of the semicylinder (621), the planar side of the rectangular block (6211) and the semicylinder (621) are both in sliding contact with the surface of the fixed rod (6142), the semicircular block (6143) can be in contact with the lower side of the semicylinder (621), and the arc side of the circular block (6141) and the semicylinder (621) are both in sliding contact with the inner side of the hollow column (72).

9. The thoracic surgical tumor tissue sample storage and analysis device of claim 8, wherein, The dynamic sealing assembly (9) comprises a sealing plate (91), an opening (92), a transmission gear set (93) and a third toothed rail (94), the sealing plate (91) is movably sleeved on the surface of the hollow column (72), the lower side of the sealing partition plate (71) is in contact with the surface of the sealing plate (91), the surface of the sealing plate (91) is provided with the opening (92) and the third toothed rail (94), the transmission gear set (93) penetrates through the hollow column (72), the gear slot (6144) is in transmission connection with one side of the transmission gear set (93), and the third toothed rail (94) is in transmission connection with the other side of the transmission gear set (93).

10. The device for storing and analyzing thoracic surgical tumor tissue samples according to claim 1, wherein, The tray module (5) further comprises a storage groove (521) and a sealing ring (55), the surface of the storage tray (52) is provided with the storage groove (521), the sample storage dish (3) can be placed in the storage groove (521), the adsorption assembly (62) can penetrate the storage groove (521), and the sealing ring (55) is fixedly arranged on the surface of the axial rod (54) and is slidingly connected between the sealing partition plate (71) and the sealing shell (1).

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