A composition for protecting liver and relieving hangover and a preparation method thereof

Abstract

The application discloses a composition for protecting liver and relieving hangover and a preparation method thereof. In one aspect, the application provides a composition for protecting liver and relieving hangover, wherein the composition comprises the following components in a weight ratio: 10-18 parts of Chinese jujube fruit, 4-10 parts of osmanthus extract, 6-12 parts of chrysanthemum, 6-12 parts of dried yam slice, 2-6 parts of Chinese wolfberry fruit, 10-18 parts of tomato powder, 4-8 parts of nutmeg and 4-10 parts of Schisandra chinensis. In another aspect, the application further provides a preparation method of the composition. The composition has a good effect of relieving hangover, can provide good protection for alcoholic liver injury, can effectively inhibit the symptoms of drunkenness, and has very small side effects.

Description

Technical Field

[0001] This application relates to the field of traditional Chinese medicine technology, and in particular to a composition for relieving hangovers and protecting the liver, and its preparation method. Background Technology

[0002] As the body's main metabolic organ, liver dysfunction can cause symptoms such as jaundice, ascites, and gastrointestinal bleeding, and may also adversely affect the function of other organs such as the kidneys, stomach, and lungs. Current medical research indicates that alcohol-induced liver damage accounts for a significant proportion of patients with liver injury and abnormal liver function.

[0003] Most hangover remedies and liver-protecting products on the market are made from traditional Chinese medicine ingredients, with kudzu root and Japanese raisin tree fruit being the most common. Both kudzu root and Japanese raisin tree fruit have good hangover-relieving effects and can alleviate symptoms of intoxication to some extent. However, excessive drinking not only causes alcoholic liver damage but also significantly harms the stomach. Overconsumption of kudzu root and Japanese raisin tree fruit can lead to gastrointestinal discomfort and other side effects. People who take these hangover remedies and liver-protecting products often have a long-term drinking habit and need to use these products for extended periods. While products with kudzu root and Japanese raisin tree fruit as main ingredients are effective in relieving hangovers and protecting the liver, long-term use can cause further damage to the stomach already damaged by alcohol. Summary of the Invention

[0004] In order to solve at least one of the above-mentioned technical problems, and to develop a hangover relief product that has a good hangover relief effect, can provide good protection against alcoholic liver damage, can effectively suppress drunkenness symptoms, and has minimal side effects, this application provides a hangover relief and liver protection composition and its preparation method.

[0005] On the one hand, this application provides a composition for relieving hangovers and protecting the liver, wherein the weight ratio of each raw material component in the composition includes: 10-18 parts of Japanese raisin tree fruit, 4-10 parts of osmanthus extract, 6-12 parts of chrysanthemum, 6-12 parts of dried yam slices, 2-6 parts of wolfberry, 10-18 parts of tomato powder, 4-8 parts of nutmeg, and 4-10 parts of schisandra fruit.

[0006] Optionally, the ingredients of the hangover relief and liver protection composition may also include mulberry, and the amount of mulberry used is 4 to 8 parts.

[0007] Optionally, the raw materials of the hangover relief and liver protection composition may also include bamboo shavings, and the amount of bamboo shavings used is 4 to 8 parts.

[0008] Optionally, the chrysanthemum used is the Qingchi chrysanthemum.

[0009] Optionally, the tomato powder is made from freeze-dried whole tomatoes.

[0010] Further, optionally, the freeze-dried whole tomato powder is prepared using the following steps:

[0011] Sa, wash the fresh tomatoes;

[0012] Sb. Place the washed tomatoes at -35~-30℃ and freeze for 15~20 minutes to obtain quick-frozen tomatoes;

[0013] Sc. Quick-frozen tomatoes are subjected to vacuum freeze-drying and then pulverized to a particle size of 35-60 mesh to obtain freeze-dried whole tomatoes.

[0014] On the other hand, this application provides a method for preparing the above-mentioned hangover-relieving and liver-protecting composition, comprising the following steps:

[0015] S1. Crush the Japanese raisin tree seeds, add water, and then boil them at 90~95℃ for 2~4 hours. Filter out the dregs to obtain the Japanese raisin tree seed decoction.

[0016] S2. Crush the remaining components except for osmanthus extract, dried yam slices, wolfberry and tomato powder, add water, and then simmer at 90~95℃ for 2~4 hours. Filter out the dregs to obtain a mixed medicinal liquid.

[0017] S3. Mix the Hovenia dulcis extract obtained in step S1 and the mixed extract obtained in step S2, then concentrate and cool to obtain a concentrated extract.

[0018] S4. Grind the dried yam slices and wolfberries into powder. Then, add the osmanthus extract, tomato powder and the powder to the concentrated medicinal liquid obtained in step S3. After mixing thoroughly, a mixture is obtained. The mixture is then concentrated under low temperature and vacuum to make an ointment, thus obtaining a composition for relieving hangovers and protecting the liver.

[0019] Optionally, in steps S1 and S2, water is added at a rate of 20-30 mL per gram of drug component; in step S3, the concentration process is performed to concentrate the drug to 1 / 8-10 of its original volume.

[0020] Optionally, in step S4, the dried yam slices and wolfberries are pulverized into powder with a particle size of 300-450 mesh.

[0021] Optionally, the temperature for the low-temperature concentration treatment of the mixture is controlled at 35~50℃.

[0022] In summary, the present invention has at least one of the following beneficial technical effects:

[0023] 1. This application uses Hovenia dulcis, Osmanthus extract, and Chrysanthemum as the main components. Hovenia dulcis relieves hangovers and protects the liver, Chrysanthemum has the effect of detoxifying and reducing liver fire, and Osmanthus extract is rich in flavonoids, which also have a good effect of relieving hangovers and protecting the liver. The above three components are the principal components, which have a good effect of relieving hangovers and protecting the liver. This application uses dried yam slices and wolfberry as the assistant components. Yam is warm in nature and strengthens the spleen and protects the stomach, while wolfberry nourishes the liver and kidneys. In addition to promoting the effect of relieving hangovers and protecting the liver, it can also suppress the cold nature of Chrysanthemum and provide a certain degree of protection for the stomach. This application uses tomato powder, nutmeg, and Schisandra chinensis as the adjuvant components. Tomato powder is rich in vitamins, pectin, fructose, and various beneficial ingredients. Nutmeg is warm in nature and has the effects of promoting qi circulation, relieving astringency, and warming the intestines. Schisandra chinensis has the effects of tonifying the kidneys and replenishing qi, promoting body fluid and diuresis. The addition of these three components can effectively protect the gastrointestinal tract and further promote the effect of relieving hangovers and protecting the liver. The above components of this application can promote each other and have a good effect of relieving hangovers, protecting the liver, and protecting the stomach and intestines.

[0024] 2. The hangover relief and liver protection composition of this application, when combined with its various components, has a good relieving effect on symptoms such as headache, nausea and vomiting caused by drunkenness.

[0025] 3. The preparation method of this application can effectively extract the main components of each drug, resulting in a drug with better hangover relief and liver protection effects, and is very easy for the human body to absorb. Attached Figure Description

[0026] Figure 1 The graph shows the detection of inflammatory factors in a long-term liver protection experiment for some of the embodiments and comparative examples.

[0027] Figure 2 Pathological photographs of liver tissue from SD rats, a long-term liver protection experimental model.

[0028] Figure 3 Pathological photographs of liver tissue from the SD rat group (Comparative Group 1) in the long-term liver protection experiment.

[0029] Figure 4 Pathological photographs of liver tissue from SD rats in the control group 2 of the long-term liver protection experiment;

[0030] Figure 5 These are pathological photographs of liver tissue from the SD rat group in Example 1 of the long-term liver protection experiment.

[0031] Figure 6 These are pathological photographs of liver tissue from the SD rat group in Example 5 of the long-term liver protection experiment.

[0032] Figure 7 These are pathological photographs of liver tissue from the SD rat group in Example 6 of the long-term liver protection experiment.

[0033] Figure 8 These are pathological photographs of liver tissue from the SD rat group in Example 8 of the long-term liver protection experiment.

[0034] Figure 9 A photograph of the stomach of an SD rat in the gastric protection experimental model group;

[0035] Figure 10 A photograph of the stomach of an SD rat in control group 1 of the gastric protection experiment;

[0036] Figure 11 A photograph of the stomach of an SD rat from the control group 2 of the gastric protection experiment;

[0037] Figure 12 This is a photograph of the stomach of an SD rat from Example 4 of the gastric protection experiment. Detailed Implementation

[0038] The present application will be further described in detail below with reference to the accompanying drawings and embodiments.

[0039] This application provides a composition for relieving hangovers and protecting the liver. The weight ratio of each raw material component in the composition includes: 10-18 parts of Japanese raisin tree fruit, 4-10 parts of osmanthus extract, 6-12 parts of chrysanthemum, 6-12 parts of dried yam slices, 2-6 parts of wolfberry, 10-18 parts of tomato powder, 4-8 parts of nutmeg, and 4-10 parts of schisandra fruit.

[0040] The method for preparing the hangover-relieving and liver-protecting composition of this application includes the following steps:

[0041] S1. Crush the Japanese raisin tree seeds, add water, and then boil them at 90~95℃ for 2~4 hours. Filter out the dregs to obtain the Japanese raisin tree seed decoction.

[0042] S2. Crush the remaining components except for osmanthus extract, dried yam slices, wolfberry and tomato powder, add water, and then simmer at 90~95℃ for 2~4 hours. Filter out the dregs to obtain a mixed medicinal liquid.

[0043] S3. Mix the Hovenia dulcis extract obtained in step S1 and the mixed extract obtained in step S2, then concentrate and cool to obtain a concentrated extract.

[0044] S4. Grind the dried yam slices and wolfberries into powder. Then, add the osmanthus extract, tomato powder and the powder to the concentrated medicinal liquid obtained in step S3. After mixing thoroughly, a mixture is obtained. The mixture is then concentrated under low temperature and vacuum to make an ointment, thus obtaining a composition for relieving hangovers and protecting the liver.

[0045] In existing technologies, hangover remedies and liver-protecting preparations are mainly formulated with traditional Chinese medicines that are both food and medicine. Preparations with kudzu root and Japanese raisin tree fruit as the main ingredients currently dominate the market.

[0046] Both kudzu root and kudzu flower have good hangover-relieving effects, and when combined with Japanese raisin tree fruit, they do indeed have a good effect on relieving hangovers and sobering up. However, alcohol not only damages the liver but also the stomach. For people who drink alcohol long-term or are alcohol-dependent, long-term alcohol stimulation can damage the gastric mucosa and cause stomach damage. The applicant found that both kudzu root and kudzu flower are cold in nature, and frequent consumption can irritate the stomach; while Japanese raisin tree fruit is neutral in nature and is contraindicated for those with weak spleen and stomach. Using these two traditional Chinese medicines as the main ingredients in a hangover-relieving combination may cause side effects such as stomach irritation, damage, and vomiting for people who drink alcohol long-term or are alcohol-dependent. The applicant reviewed existing technologies and found that some existing research also shows that some patients who drink alcohol experience limited relief of hangover symptoms when taking preparations with kudzu root and Japanese raisin tree fruit as the main ingredients. And there has been no good solution to the above problems.

[0047] The applicant, through research, discovered the aforementioned problems and further found that existing formulations using kudzu root and Japanese raisin tree fruit as the main ingredients have limited effectiveness in relieving hangover symptoms, which are actually caused by stomach discomfort rather than alcohol intoxication. Based on this, the applicant designed the composition of this application, which does not use kudzu root or kudzu flower, but combines other drugs with Japanese raisin tree fruit. This composition effectively relieves hangovers and protects the liver while also protecting the stomach and gastric mucosa, thus solving the problems existing in the prior art.

[0048] The following are preparation examples and embodiments of this application.

[0049] The main raw material sources for the preparation examples and embodiments of this application are as follows:

[0050] Hovenia dulcis seeds were purchased from Bozhou Kangjiuqi Pharmaceutical Co., Ltd.; Osmanthus extract and extract solution were purchased from Guangzhou Meiyi Biotechnology Co., Ltd.; Chrysanthemum morifolium, Chrysanthemum indicum, dried yam slices, wolfberry, nutmeg, Schisandra chinensis, mulberry and bamboo shavings were all purchased from Beijing Tongrentang.

[0051] Preparation Example 1

[0052] The tomato powder in this preparation example was prepared using the following steps:

[0053] Sa, wash the fresh tomatoes;

[0054] Sb. After washing and crushing the tomatoes, immediately heat them to 85℃ and keep them warm for 5 minutes to deactivate the pectinase.

[0055] Sc. After crushing and passivating the tomato pieces, mash them into a pulp and then filter them through a 6mm mesh sieve.

[0056] Sd. The filtered slurry is spray-dried to solidify at a temperature of 95~100℃ and a homogenization pressure of 120~125MPa to obtain tomato powder.

[0057] Preparation Example 2

[0058] The tomato powder in this preparation example was prepared using the following steps:

[0059] Sa, wash the fresh tomatoes;

[0060] Sb. The washed tomatoes are dried with hot air to constant weight at a temperature of 100~105℃.

[0061] Sc. Crush dehydrated tomatoes to a particle size of 35-60 mesh to obtain tomato powder.

[0062] Preparation Example 3

[0063] The tomato powder in this preparation example was prepared using the following steps:

[0064] Sa, wash the fresh tomatoes;

[0065] Sb. Place the washed tomatoes at -35~-30℃ and freeze for 15 minutes to obtain frozen tomatoes;

[0066] Sc. Quick-frozen tomatoes are subjected to vacuum freeze-drying to constant weight, and then pulverized to a particle size of 35-60 mesh to obtain freeze-dried tomato powder.

[0067] Example 1

[0068] The weight proportions of each ingredient in the hangover relief and liver protection composition of this embodiment include: 10 parts of Japanese raisin tree fruit, 4 parts of osmanthus extract, 6 parts of chrysanthemum, 6 parts of dried yam slices, 2 parts of wolfberry, 18 parts of tomato powder, 4 parts of nutmeg, and 4 parts of schisandra.

[0069] The preparation method of the hangover-relieving and liver-protecting composition of this embodiment includes the following steps:

[0070] S1. Crush the Japanese raisin tree fruit into particles of 1-5mm, add 20 times the weight of water, and then boil at 90-95℃ for 2 hours. Filter out the dregs to obtain the Japanese raisin tree fruit decoction.

[0071] S2. Crush the remaining components except for osmanthus extract, dried yam slices, wolfberry and tomato powder to a particle size of 1-5mm, add 20 times the weight of water, and then simmer at 90-95℃ for 2 hours. Filter out the dregs to obtain a mixed medicinal liquid.

[0072] S3. Mix the Hovenia dulcis extract obtained in step S1 with the mixed extract obtained in step S2, and then concentrate it at 50°C to 1 / 8 of the original volume. After cooling, the concentrated extract is obtained.

[0073] S4. Grind the dried yam slices and wolfberries into powder with a particle size of 300-450 mesh. Then, add the osmanthus extract, the tomato powder from Preparation Example 1 and the powder obtained from the grinding to the concentrated medicinal liquid obtained in step S3. After thorough mixing, a mixture is obtained. The mixture is then concentrated under low temperature and vacuum to make an ointment, thus obtaining a composition for relieving hangovers and protecting the liver.

[0074] Example 2

[0075] The difference between this embodiment and Embodiment 1 lies in the preparation method.

[0076] The preparation method of the hangover-relieving and liver-protecting composition of this embodiment includes the following steps:

[0077] S1. Crush the Japanese raisin tree fruit into particles of 1-5mm, add 25 times the weight of water, and then boil at 90-95℃ for 3 hours. Filter out the dregs to obtain Japanese raisin tree fruit decoction.

[0078] S2. Crush the remaining components except for osmanthus extract, dried yam slices, wolfberry and tomato powder to a particle size of 1-5mm, add 25 times the weight of water, and then simmer at 90-95℃ for 3 hours. Filter out the dregs to obtain a mixed medicinal liquid.

[0079] S3. Mix the Hovenia dulcis extract obtained in step S1 with the mixed extract obtained in step S2, and then concentrate it at 35°C to 1 / 9 of the original volume. After cooling, the concentrated extract is obtained.

[0080] S4. Grind the dried yam slices and wolfberries into powder with a particle size of 300-450 mesh. Then, add the osmanthus extract, the tomato powder from Preparation Example 1 and the powder obtained from the grinding to the concentrated medicinal liquid obtained in step S3. After thorough mixing, a mixture is obtained. The mixture is then concentrated under low temperature and vacuum to make an ointment, thus obtaining a composition for relieving hangovers and protecting the liver.

[0081] Example 3

[0082] The difference between this embodiment and Embodiment 1 lies in the preparation method.

[0083] The preparation method of the hangover-relieving and liver-protecting composition of this embodiment includes the following steps:

[0084] S1. Crush the Japanese raisin tree fruit into particles of 1-5mm, add 30 times the weight of water, and then boil at 90-95℃ for 4 hours. Filter out the dregs to obtain the Japanese raisin tree fruit decoction.

[0085] S2. Crush the remaining components, except for osmanthus extract, dried yam slices, wolfberry and tomato powder, to a particle size of 1-5mm, add 30 times the weight of water, and then simmer at 90-95℃ for 4 hours. Filter out the dregs to obtain a mixed medicinal liquid.

[0086] S3. Mix the Hovenia dulcis extract obtained in step S1 with the mixed extract obtained in step S2, and then concentrate it at a low temperature of 45°C to 1 / 10 of the original volume. After cooling, the concentrated extract is obtained.

[0087] S4. Grind the dried yam slices and wolfberries into powder with a particle size of 300-450 mesh. Then, add the osmanthus extract, the tomato powder from Preparation Example 1 and the powder obtained from the grinding to the concentrated medicinal liquid obtained in step S3. After thorough mixing, a mixture is obtained. The mixture is then concentrated under low temperature and vacuum to make an ointment, thus obtaining a composition for relieving hangovers and protecting the liver.

[0088] Example 4

[0089] The difference between this embodiment and Embodiment 3 is that the raw material ratios are different.

[0090] The weight proportions of each ingredient in the hangover relief and liver protection composition of this embodiment include: 18 parts of Japanese raisin tree fruit, 10 parts of osmanthus extract, 12 parts of chrysanthemum, 12 parts of dried yam slices, 6 parts of wolfberry, 10 parts of tomato powder, 8 parts of nutmeg, and 10 parts of schisandra.

[0091] Example 5

[0092] The difference between this embodiment and Embodiment 3 is that the raw material ratios are different.

[0093] The weight proportions of each ingredient in the hangover relief and liver protection composition of this embodiment include: 14 parts of Japanese raisin tree fruit, 8 parts of osmanthus extract, 10 parts of chrysanthemum, 8 parts of dried yam slices, 4 parts of wolfberry, 16 parts of tomato powder, 6 parts of nutmeg, and 6 parts of schisandra.

[0094] Example 6

[0095] The difference between this embodiment and embodiment 5 is that an equal amount of Qingchi chrysanthemum is used to replace Hang chrysanthemum.

[0096] Example 7

[0097] The difference between this embodiment and Example 6 is that the tomato powder prepared in Example 2 is used.

[0098] Example 8

[0099] The difference between this embodiment and Example 6 is that the tomato powder prepared in Example 3 is used.

[0100] Example 9

[0101] The difference between this embodiment and Embodiment 8 is that the ingredients of the hangover relief and liver protection composition also include 6 parts of mulberry.

[0102] Example 10

[0103] The difference between this embodiment and Embodiment 9 is that the ingredients of the hangover relief and liver protection composition also include 6 parts of bamboo shavings.

[0104] Comparative Example 1

[0105] This application uses the kudzu root and jujube seed tablets produced by Anhui Heyun Guoyao Co., Ltd. as comparative example 1.

[0106] Comparative Example 2

[0107] This application uses kudzu flower hangover tea as comparative example 2. The formula contains the following proportions by weight: 15 parts kudzu flower, 12 parts Japanese raisin tree fruit, 6 parts dried tangerine peel, and 15 parts dried hawthorn.

[0108] The preparation method of this comparative hangover relief tea includes the following steps:

[0109] S1. Grind the raw materials in the formula to a particle size of 1~5mm;

[0110] S2. Add 4 times the weight of water, then simmer at 90~95℃ for 2 hours. Filter out the dregs to obtain kudzu flower hangover relief tea.

[0111] The kudzu flower hangover tea was concentrated to 1 / 12 of its original volume to obtain a concentrated kudzu flower hangover tea liquid.

[0112] The following is the experimental testing section of this application.

[0113] 1. Animal experiments on hangover relief and sobering up

[0114] Animal selection:

[0115] SPF-grade SD rats were selected as experimental animals.

[0116] Grouping:

[0117] 112 healthy SD rats were randomly selected and divided into 14 groups of 8 rats each, ensuring that the total weight deviation of the SD rats in each group did not exceed 20g. There were 14 groups in total: blank control group, model group, Examples 1-10, and Comparative Examples 1-2.

[0118] experiment:

[0119] After feeding all SD rats normally for 5 days, the experiment was started. The control group of SD rats were not treated and were fed normally.

[0120] Except for the blank group, each of the 13 SD rat groups was administered 0.03 mL / g of 42° Erguotou (a type of Chinese liquor) by gavage and then waited for 30 min.

[0121] Each SD rat in the model group was administered the hangover-relieving and liver-protecting composition of Examples 1-10 at a dose of 0.004 mL / g via gavage with purified water. In Comparative Example 1, each SD rat was administered the hangover-relieving and liver-protecting composition of Examples 1-10 at a dose of 0.004 mL / g via gavage with purified water at a ratio of 1:4. In Comparative Example 2, each SD rat was administered a concentrated kudzu flower hangover-relieving tea at a dose of 0.005 mL / g via gavage with purified water at a ratio of 1:3.

[0122] Blood was collected from the jugular vein of each SD rat before feeding Erguotou, 30 minutes after feeding Erguotou, and 30 minutes after administration, and the concentration of ethanol in the blood was then measured.

[0123] Thirty minutes after administration, the righting reflex was observed in all SD rats, and the righting reflex recovery time for each SD rat was recorded.

[0124] The average value of the test data for each group of SD rats was taken, and the results are shown in Table 1.

[0125] 2. Long-term liver protection experiment

[0126] Grouping:

[0127] One hundred and fourteen healthy SD rats were randomly selected and divided into 13 groups of eight rats each, ensuring that the total weight of the SD rats in each group did not differ by more than 20g. There were a model group, Examples 1-10, and Comparative Examples 1-2, for a total of 13 groups.

[0128] Constructing an alcoholic liver injury model:

[0129] After feeding all SD rats normally for 5 days, modeling began;

[0130] The rats were administered 42° Erguotou (a type of Chinese liquor) by gavage at a dose of 0.04 mL / g per day for 14 days to complete the modeling process.

[0131] Then, the SD rats were fed normally for 7 days, and each SD rat was treated with the same dosage as in the animal experiment on alcohol detoxification and sobering up.

[0132] Blood samples were taken from the jugular vein of SD rats before and after modeling to detect the serum levels of IFN-γ and IL-17. Then, at the end of the treatment, blood was taken from the jugular vein of each SD rat to detect the serum levels of IFN-γ and IL-17.

[0133] One SD rat from each group was randomly selected for euthanasia, and its liver was then removed. The largest lobe of the liver was then taken for histopathological analysis.

[0134] The experimental results are shown in Table 2 and the attached figure.

[0135] Table 1. Results of hangover relief and sobering-up experiments in Examples 1-10 and Comparative Examples 1-2

[0136] ;

[0137] Table 2. Results of liver protection experiments in Examples 1-10 and Comparative Examples 1-2

[0138] ;

[0139] As can be seen from the data in Table 1, the hangover relief and liver protection compositions of Examples 1-10 of this application have better hangover relief effects than the products of Comparative Example 1 and Comparative Example 2. After administration, the blood alcohol content of SD rats decreased more significantly than that of the model group. In addition, the hangover relief and liver protection compositions of Examples 1-10 of this application have significantly better hangover relief effects than the products of Comparative Example 1 and Comparative Example 2, and the righting reflex recovery time is significantly shorter.

[0140] The data in Table 1, comparing the hangover relief data of Examples 1-10 of this application, shows that the hangover relief data of Example 5 is slightly better than that of Examples 1-4, the hangover relief data of Example 6 is significantly better than that of Example 5, and the hangover relief data of Examples 9 and 10 are better than that of Example 6. It is evident that the optimized formulation of this application results in a better hangover relief effect; the use of Qingchi chrysanthemum in this application significantly enhances the hangover relief effect; and the addition of mulberry and bamboo shavings further improves the hangover relief effect.

[0141] Furthermore, a comparison of the hangover relief data in Examples 1-10 of this application in Table 1 shows that the data for Example 6 is significantly better than that for Examples 1-5, with Example 10 showing the best performance. This demonstrates that the optimized formulation and the addition of bamboo shavings significantly improve the hangover relief effect.

[0142] Based on the data in Table 2 and Figure 1 It can be seen that the data of Examples 1 to 10 of this application are significantly better than those of Comparative Example 1 and Comparative Example 2; it is evident that the liver-protecting composition of this application has significantly better liver-protecting efficacy.

[0143] The data in Table 2, comparing the data from Examples 1-10 of this application, shows that the data from Example 6 is significantly better than that from Examples 1-5, and the data from Example 9 is significantly better than that from Example 8. This indicates that the optimized formulation of this application does not significantly affect the liver-protective efficacy; however, the use of Chrysanthemum morifolium significantly enhances the liver-protective efficacy; and the addition of mulberry further optimizes the composition of each group, resulting in a further significant improvement in the liver-protective effect.

[0144] Furthermore, the results of histopathological analysis corroborate the data in Table 2. Figure 2 It can be seen that after alcohol injury, the SD rats in the model group showed significant liver damage and relatively more fibrotic tissue. Meanwhile, the... Figures 3-8 It can be seen that the product of Comparative Example 1 has a certain liver-protecting effect. After the experiment, the liver damage area was small and the fibrosis tissue was relatively small. The product of Comparative Example 2 has a significantly lower liver-protecting effect than Comparative Example 1. After the experiment, the liver damage area was relatively larger and the fibrosis tissue was also larger. The composition of Example 1 of this application has a very obvious liver-protecting effect. After the experiment, only a very small part of the liver was damaged and there was very little fibrosis tissue. The composition of Example 5 of this application, after optimization of the ratio, has a certain improvement in liver-protecting effect compared with Example 1. After the experiment, the liver damage area and fibrosis tissue were lower than those of Example 1. The product of Example 6 of this application, after using Chrysanthemum indicum, has a significantly improved liver-protecting effect. After the experiment, the liver damage area was further reduced compared with Example 5, and there was no fibrosis tissue present. The product of Example 8, after using the tomato powder of this application, did not show a significant improvement in liver-protecting effect. The product of Example 9, after adding mulberry, showed a slight improvement in liver-protecting effect compared with Example 6 according to histopathological analysis. It is evident that this application demonstrates excellent liver-protecting effects after using Chrysanthemum indicum and adding mulberry, and can significantly inhibit liver fibrosis.

[0145] 3. Stomach-protecting experiment

[0146] Grouping:

[0147] One hundred and fourteen healthy SD rats were randomly selected and divided into 13 groups of eight rats each, ensuring that the total weight of the SD rats in each group did not differ by more than 20g. There were a model group, Examples 1-10, and Comparative Examples 1-2, for a total of 13 groups.

[0148] experiment:

[0149] After feeding all SD rats normally for 5 days, the experiment began;

[0150] SD rats were administered 42° Erguotou (a type of Chinese liquor) via gavage at a dose of 0.025 mL / g per day for 14 days. During this period, each SD rat was given the same dosage as in the animal experiments on alcohol detoxification and sobering up.

[0151] Each group of SD rats was euthanized, and then their stomachs were removed, cut open along the greater curvature, and then observed and photographed under a microscope to analyze the damage to the gastric mucosa.

[0152] The analysis of gastric mucosal tissue damage uses image analysis methods. The photographs are imported into image processing software, and the software is used to analyze and calculate the average percentage of the area of ​​the bleeding part relative to the total flat area of ​​the gastric resection.

[0153] The results are shown in Table 3. A photograph of the stomach of one rat from any of the four groups was randomly selected from the experimental rats. Figures 9-12 As shown.

[0154] Table 3 Results of gastric protection experiments in Examples 1-10 and Comparative Examples 1-2

[0155] ;

[0156] As can be seen from the data in Table 3, the hangover-relieving and liver-protecting compositions of Examples 1-10 of this application have a very significant protective effect on the stomach, far exceeding that of Comparative Examples 1 and 2. The product of Comparative Example 1 showed very little stomach-protecting effect, with no significant difference compared to the model group; the product of Comparative Example 2 could inhibit alcohol damage to the stomach to some extent, but its stomach-protecting effect was poor. In contrast, the hangover-relieving and liver-protecting compositions of this application have excellent stomach-protecting effects, and after administration, can greatly reduce the damage caused by alcohol to the stomach. It is evident that combining tomato powder with other drugs not only enhances the hangover-relieving effect but also greatly improves the stomach-protecting effect of the composition.

[0157] like Figure 9 As shown, long-term alcohol consumption causes significant damage to the stomach. In the model group of SD rats, the stomach damage was more severe after the experiment, with extensive damage to the gastric mucosa and large areas of bleeding. Figure 10 As shown, in Comparative Example 1, kudzu root and Japanese raisin tree fruit were the main ingredients. After administration, alcohol still caused significant damage to the gastric mucosa and stomach. Although the effect of relieving alcohol intoxication was good, it provided almost no effective protection for the stomach. SD rats showed significant gastric damage and numerous bleeding sites. However, as... Figure 11 As shown, the product in Comparative Example 2 uses kudzu flower and Japanese raisin tree fruit as the main ingredients, supplemented with dried tangerine peel and hawthorn. It has a certain stomach-strengthening effect. Although its hangover-relieving effect is not as good as Comparative Example 1, its effect in inhibiting stomach damage is significantly better than Comparative Example 1. Figure 12 As shown, the composition of Example 4 of this application uses a relatively low amount of tomato powder, therefore its stomach-protecting effect is significantly lower than that of other examples. However, due to... Figure 12 It can be seen that the composition of Example 4 of this application still has a very good gastric protection effect, with very small gastric lesion area and minimal bleeding in SD rats.

[0158] From the data in Table 3, comparing the data of Examples 1 to 10, and combining the tissue damage analysis results, it can be seen that the tomato powder dosage of this application is appropriately increased, resulting in a better stomach-protecting effect. In addition, the freeze-dried whole tomato powder prepared at low temperature in this application significantly enhances the protective effect on the stomach. Finally, the stomach-protecting effect can be further improved after adding bamboo shavings.

[0159] It is evident that low-temperature preparation of tomato powder can effectively maintain the activity of various components of tomatoes, and in the formulation of this application, it can effectively protect and repair the gastric mucosa. Furthermore, the combination of bamboo shavings and freeze-dried whole tomato powder has an even better effect on protecting and repairing the gastric mucosa.

[0160] The above are all preferred embodiments of this application and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A composition for protecting liver from alcohol, characterized in that, The alcohol-eliminating and liver-protecting composition is prepared from the following components in parts by weight: 10-18 parts of jujube fruit, 4-10 parts of osmanthus extract, 6-12 parts of chrysanthemum, 6-12 parts of dried yam slice, 2-6 parts of medlar, 10-18 parts of tomato powder, 4-8 parts of nutmeg, and 4-10 parts of schisandra.

2. A composition for protecting liver from alcohol, characterized in that, The alcohol-eliminating and liver-protecting composition is prepared from the following components in parts by weight: 10-18 parts of jujube fruit, 4-10 parts of osmanthus extract, 6-12 parts of chrysanthemum, 6-12 parts of dried yam slice, 2-6 parts of medlar, 10-18 parts of tomato powder, 4-8 parts of nutmeg, 4-10 parts of schisandra, and 4-8 parts of mulberry.

3. A composition for hangover prevention and liver protection, characterized by, The alcohol-eliminating and liver-protecting composition is prepared from the following components in parts by weight: 10-18 parts of jujube fruit, 4-10 parts of osmanthus extract, 6-12 parts of chrysanthemum, 6-12 parts of dried yam slice, 2-6 parts of medlar, 10-18 parts of tomato powder, 4-8 parts of nutmeg, 4-10 parts of schisandra, 4-8 parts of mulberry, and 4-8 parts of bamboo shavings.

4. The hangover-preventing composition according to any one of claims 1 to 3, wherein The chrysanthemum is selected from Qingchi chrysanthemum.

5. The hangover-preventing composition according to any one of claims 1 to 3, wherein The tomato powder is selected from whole tomato freeze-dried powder.

6. The hangover-preventing composition according to claim 5, characterized by, The whole tomato freeze-dried powder is prepared by the following steps: Sa, washing fresh tomatoes; Sb, freezing the washed tomatoes at a temperature of -35 to -30°C for 15-20 min to obtain quick-frozen tomatoes; Sc, vacuum freeze-drying the quick-frozen tomatoes, and then crushing them to a particle size of 35-60 mesh to obtain the whole tomato freeze-dried powder.

7. A method for preparing a composition for relieving hangovers and protecting the liver as described in any one of claims 1 to 3, characterized in that, The method comprises the following steps: S1, crushing jujube fruit, adding water, and then boiling at a temperature of 90-95°C for 2-4 h to obtain jujube fruit liquid by filtering out the residue; S2, crushing the remaining components except for osmanthus extract, dried yam slice, medlar, and tomato powder, adding water, and then boiling at a temperature of 90-95°C for 2-4 h to obtain a mixed liquid by filtering out the residue; S3, mixing the jujube fruit liquid obtained in step S1 and the mixed liquid obtained in step S2, and then concentrating to obtain a concentrated liquid after cooling; S4, crushing dried yam slice and medlar into powder, and then adding osmanthus extract, tomato powder, and the obtained powder to the concentrated liquid obtained in step S3, and mixing to obtain a mixed liquid, and then concentrating the mixed liquid at low temperature under vacuum to obtain the alcohol-eliminating and liver-protecting composition.

8. The method of claim 7, wherein the alcohol liver-protecting composition is prepared by mixing the alcohol liver-protecting agent and the alcohol liver-protecting agent carrier. In steps S1 and S2, water is added at an amount of 20-30 mL per gram of medicinal components; in step S3, the concentration treatment is concentrated to 1 / 8-10 of the original volume.

9. The method for preparing the hangover-relieving and liver-protecting composition according to claim 7, characterized in that, In step S4, the dried yam slice and medlar are crushed to a particle size of 300-450 mesh.

10. The method for preparing the composition for relieving hangovers and protecting the liver according to claim 7, characterized in that, The temperature of the low-temperature concentration treatment of the mixed liquid is controlled at 35-50°C.

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