Purification equipment and process applied to amoxicillin sodium production

Abstract

The application relates to the technical field of filter pressing devices, and discloses a purification equipment and process applied to amoxicillin sodium production, wherein the purification equipment applied to amoxicillin sodium production comprises an equipment frame, a plurality of filter plate mechanisms arranged in the equipment frame, the filter plate mechanism comprises a filter frame fixedly connected with a roller, a filter cloth assembly used for filtering filtrate, a material pipe assembly used for conveying fermentation liquid, an unfolding assembly used for unfolding the filter cloth assembly, and an adjusting assembly used for adjusting the unfolding assembly; the filter plate mechanism and the driving assembly are combined, the driving motor drives the driving gear to rotate, when the sliding rack is parallel to the ground, the sliding rack is engaged with the driving gear and the adjusting gear, the rotating motion of the driving motor is transmitted to the adjusting rod, the unfolding degree of the filter cloth assembly is adjusted, the situation that the filter pressure is unevenly distributed is avoided, the stable filtering speed is maintained, and the overall production efficiency is improved.

Description

Technical Field

[0001] This invention relates to the field of pressure filtration equipment technology, and in particular to a purification device and process for the production of amoxicillin sodium. Background Technology

[0002] Amoxicillin sodium is a commonly used antibiotic, and the purification process is crucial in its production. Currently, plate and frame filter presses are the commonly used equipment for the purification of amoxicillin sodium. However, traditional plate and frame filter presses suffer from low filtration efficiency, slow processing speed when handling high-concentration fermentation broths, and easy clogging of the filter cloth. Unloading the filter cake is difficult, requiring manual operation and resulting in high labor intensity. Automation is low, making precise parameter control difficult. Cleaning is ineffective, easily leaving impurities that lead to cross-contamination. Although technological improvements have been made, limitations remain in filtration, unloading, automation, and cleaning, necessitating the development of new, highly efficient equipment.

[0003] The existing technology has the following drawbacks:

[0004] Low filtration efficiency: During the filtration process of amoxicillin sodium crystallization, the filter cake accumulates rapidly, causing a sharp increase in filtration resistance and a significant decrease in filtration speed. Traditional equipment struggles to adjust filtration parameters based on the real-time condition of the filter cake, severely impacting overall production efficiency. Furthermore, uneven accumulation of the filter cake leads to uneven distribution of filtration pressure within the filter chamber, resulting in poor filtration in some areas and excessive pressure in others, causing filter cloth damage. This not only affects product quality but also shortens equipment lifespan and significantly increases production costs.

[0005] Difficulty in unloading filter cake: After filtration, the filter cake will adhere tightly to the filter cloth. In current equipment, the filter cake often needs to be manually peeled off the filter cloth during unloading. This operation is not only cumbersome, but also extremely inefficient, requiring a lot of manpower and time, which seriously restricts the improvement of production efficiency.

[0006] Inconvenient filter cloth replacement: After a period of use, the filter cloth needs to be replaced to ensure the filtration effect. However, the filter cloth replacement operation of traditional plate and frame filter press is quite complicated and requires a lot of time and manpower. Frequent replacement not only increases labor costs, but also causes production interruption, affecting the continuity and stability of production. Summary of the Invention

[0007] Given the problems of low filtration efficiency, difficulty in unloading filter cake, and inconvenience in replacing filter cloth in existing technologies, a purification device and process for the production of amoxicillin sodium is proposed.

[0008] One aspect of this application provides a purification device for the production of amoxicillin sodium. Its purpose is to: adjust the filtration pressure by combining a filter plate mechanism and a drive assembly, avoiding uneven pressure distribution and maintaining a stable filtration speed, thereby improving overall production efficiency; simultaneously, it prevents filter cloth damage due to excessive local pressure, ensuring product quality and extending equipment lifespan; furthermore, this combination facilitates the separation of the filter cake from the filter cloth, reducing manual labor intensity and improving unloading efficiency; and the filter cloth is installed using a snap-fit ​​method, simplifying replacement and reducing the time and labor costs required for filter cloth replacement, thus ensuring the continuity and stability of production.

[0009] The technical solution of the present invention is as follows: a purification device for the production of amoxicillin sodium, comprising a device frame, a drive assembly externally disposed on the adjusting gear, multiple filter plate mechanisms disposed inside the device frame, and rollers fixedly installed on both sides of the filter plate mechanisms. The filter plate mechanisms slide on the top of the device frame via the rollers on both sides. The filter plate mechanisms include filter frames fixedly connected to the rollers, filter cloth assemblies for filtering out filtrate, feed pipe assemblies for conveying fermentation broth, spreading and supporting assemblies for expanding the filter cloth assemblies, and adjusting assemblies for adjusting the spreading and supporting assemblies. The inner wall of the filter frame is provided with a liquid outlet, and a pressure filtration chamber is formed between two adjacent filter frames.

[0010] The feed tube assembly includes two fixed plates fixedly connected to the filter frame, a feed tube fixedly connected between the two fixed plates, two symmetrically arranged sliding rings slidably connected to the outer wall of the feed tube, and multiple telescopic springs fixedly connected between the feed tube and the sliding rings. The sliding rings provide guidance for the filter cloth assembly to open. Multiple snap-fit ​​posts are fixedly connected to the outer walls of both the filter frame and the sliding rings. The snap-fit ​​posts are used to fix and install the filter cloth assembly.

[0011] The above-mentioned scheme features a feed pipe assembly. The feed pipe serves as the channel for transporting the fermentation broth, accurately delivering it to the filter press chamber to ensure its smooth participation in the purification process. The sliding ring is slidably connected to the outer wall of the feed pipe and via a telescopic spring. When the support assembly expands the filter cloth assembly, the telescopic spring stretches or compresses, causing the sliding ring to slide. The sliding ring provides precise guidance for the filter cloth assembly to expand, ensuring even expansion and preventing local wrinkles or tightness. This fully utilizes the filtration area, improving filtration effect and efficiency.

[0012] Furthermore, the filter cloth assembly includes a filter cloth outer frame and a filter cloth inner ring, as well as a microporous filter cloth fixedly connected between the filter cloth outer frame and the filter cloth inner ring. The inner walls of the filter cloth outer frame and the filter cloth inner ring are provided with multiple snap-fit ​​holes, and the filter cloth assembly is snapped between the filter frame and the sliding ring through the snap-fit ​​holes.

[0013] The above-mentioned scheme, through the filter cloth assembly, effectively filters the fermentation broth and separates solid impurities, with significant results. It not only improves the purification quality of amoxicillin sodium and ensures the purity and quality of the product, but also reduces equipment maintenance time and costs due to its convenient installation and replacement, thereby increasing production efficiency and providing a strong guarantee for the large-scale production of amoxicillin sodium.

[0014] Furthermore, the adjustment assembly includes an adjustment rod rotatably connected to the filter frame and the feed tube, and the adjustment rod extends to the outer wall of the filter frame and is fixedly connected to an adjustment gear and an adjustment handwheel.

[0015] Using the above scheme, through the set adjustment components, when the adjustment gear meshes with the sliding rack, multiple adjustment rods can be mechanically operated to rotate synchronously; when the adjustment gear disengages from the sliding rack, a single adjustment rod can be manually operated to rotate.

[0016] Furthermore, the support assembly includes a limiting block fixedly connected to the outer wall of the adjusting rod, a first support rod hinged to the inner wall of the limiting block, the first support rod swinging inside the limiting block, a second support rod slidably connected to the inner wall of the first support rod, and an extension spring fixedly connected between the inner wall of the first support rod and the outer wall of the second support rod.

[0017] Furthermore, the support assembly also includes a swing block hinged to the inner wall of the adjusting rod, the swing block swinging inside the adjusting rod, and a connecting spring fixedly connecting the swing block and the first support rod.

[0018] By adopting the above scheme, the adjustment action of the adjustment component is converted into a force for opening the filter cloth component through the set support component. When the operator drives the adjustment rod to rotate by adjusting the gear or adjusting the handwheel, the limit block moves accordingly. Through the coordinated action of the first support rod, the second support rod, the swing block and the connecting spring, the power is transmitted and amplified to effectively open the filter cloth component. As a result, the filtration area of ​​the filter cloth component is fully utilized, and the fermentation broth can pass through the filter cloth more evenly, improving the filtration efficiency and filtration quality, thereby enhancing the purification effect of amoxicillin sodium.

[0019] Furthermore, the drive assembly includes a fixed frame and a swing frame that are fixedly connected to the equipment frame. A sliding rack is hinged inside the fixed frame and the swing frame. Sliding grooves are provided at both ends of the sliding rack. The sliding rack slides inside the fixed frame and the swing frame through the sliding grooves. A push button is slidably connected to the outer wall of the swing frame. The push button is used to adjust the tilt angle of the sliding rack.

[0020] Furthermore, the drive assembly also includes a drive motor fixedly connected to the equipment frame, and the output shaft of the drive motor is fitted with a drive gear. When the sliding rack is parallel to the ground, it meshes with both the drive gear and the adjusting gear.

[0021] By adopting the above scheme, the drive motor drives the drive gear to rotate through the set drive component. When the sliding rack is parallel to the ground, it meshes with both the drive gear and the adjusting gear, thereby transmitting the rotational motion of the drive motor to the adjusting rod, realizing the drive of the spreading and supporting component, and thus adjusting the degree of expansion of the filter cloth component. This reduces the workload of manual operation and improves the automation level of the production process. This makes the purification and production of amoxicillin sodium more efficient and stable, and can meet the needs of large-scale production.

[0022] Furthermore, a telescopic hydraulic cylinder is fixedly installed at one end of the equipment frame, and a pressure plate is fixedly connected to the output end of the telescopic hydraulic cylinder. Both sides of the pressure plate are connected to rollers.

[0023] Furthermore, a thrust plate is fixedly installed at the other end of the equipment frame, and a conveying pipe is fixedly connected inside the thrust plate. The conveying pipe is connected to the feed pipe and the filter press chamber.

[0024] Using the above scheme, the clamping plate and thrust plate are set up, the telescopic hydraulic cylinder pushes the clamping plate, and the rollers make the clamping plate move more smoothly. The clamping plate and the thrust plate work together to apply pressure to the filter frame and other components to form a sealed filtration environment. The feed pipe transports the material to the feed pipe and the filtration chamber to achieve material filtration and ensure the efficient solid-liquid separation in the purification production of amoxicillin sodium.

[0025] Another aspect of this application provides a production process for a purification device used in the production of amoxicillin sodium, comprising the following steps:

[0026] Step 1: Combine multiple filter plate mechanisms, and engage the drive component and adjustment component;

[0027] Step 2: Input the fermentation broth for amoxicillin sodium production, which is then filled into each filter press chamber through the feed pipe assembly;

[0028] Step 3: Set the pressure of the filter press to initially separate the solid and liquid components in the fermentation broth and obtain the filtrate;

[0029] Step 4: Run the drive component, adjust the component to drive the support component to rotate, adjust the filtration pressure, and further squeeze out the filtrate from the filter cake in the filter press chamber;

[0030] Step 5: The filtrate is discharged through the outlet;

[0031] Step Six: Separate the operation drive component from the adjustment component;

[0032] Step 7: Pull out each filter plate mechanism in sequence, and manually operate the adjustment component to drive the support component to rotate, so as to separate the filter cake;

[0033] Step 8: Separate the filter cloth assembly for cleaning.

[0034] The beneficial effects of this invention are:

[0035] By combining the filter plate mechanism and drive assembly, the drive motor drives the drive gear to rotate. When the sliding rack is parallel to the ground, it meshes with both the drive gear and the adjusting gear, transmitting the rotational motion of the drive motor to the adjusting rod. As the adjusting rod rotates, the limit block moves accordingly. Through the coordinated action of the first support rod, the second support rod, the swing block, and the connecting spring, the power is transmitted and amplified, thereby adjusting the degree of expansion of the filter cloth assembly and thus adjusting the filtration pressure. This avoids uneven distribution of filtration pressure, maintains a stable filtration speed, improves overall production efficiency, and prevents filter cloth damage due to excessive local pressure, ensuring product quality and extending the service life of the equipment.

[0036] With the filter plate mechanism, adjustment component and support component set up, after filtration is completed, the operation drive component is separated from the adjustment component. Then, the adjustment component is manually operated to drive the support component to rotate. When the support component rotates, it exerts a force on the filter cake, causing the filter cake to separate from the filter cloth. This reduces the intensity of manual operation, improves the unloading efficiency, and solves the problem of filter cake being tightly attached to the filter cloth and difficult to unload.

[0037] The filter cloth assembly is installed using a snap-fit ​​method. Multiple snap-fit ​​holes are provided on the inner walls of both the outer frame and the inner ring of the filter cloth, which snap the assembly between the filter frame and the sliding ring. When the filter cloth needs to be replaced after a period of use, simply separate the filter cloth assembly from the snap-fit ​​between the filter frame and the sliding ring to easily remove and replace it. This simplifies the replacement operation, reduces the time and labor costs required for filter cloth replacement, and ensures the continuity and stability of production. Attached Figure Description

[0038] Figure 1 This is a schematic diagram of the overall structure of the present invention;

[0039] Figure 2 This is a schematic diagram of the structure of the telescopic hydraulic cylinder of the present invention;

[0040] Figure 3 This is a schematic diagram of the filter plate mechanism of the present invention;

[0041] Figure 4 This is a schematic diagram of the filter frame structure of the present invention;

[0042] Figure 5 This is a schematic diagram of the filter cloth assembly of the present invention;

[0043] Figure 6 This is a schematic diagram of the structure of the adjustment component of the present invention;

[0044] Figure 7 This is a schematic diagram of the material tube assembly of the present invention;

[0045] Figure 8 This is a schematic diagram of the structure of the support component of the present invention;

[0046] Figure 9 This is a schematic diagram of the structure of the extended spring of the present invention;

[0047] Figure 10 This is a schematic diagram of the material passage pipe structure of the present invention;

[0048] Figure 11 This is a schematic diagram of the filter cloth assembly of the present invention during the spreading process;

[0049] Figure 12 This is a schematic diagram of the structure of the filter press chamber of the present invention;

[0050] Figure 13 This is a schematic diagram of the structure of the drive component of the present invention;

[0051] Figure 14 This is a schematic diagram of the sliding rack structure of the present invention.

[0052] In the picture:

[0053] 1. Equipment frame; 2. Feed pipe; 3. Thrust plate; 4. Roller; 5. Filter plate mechanism; 51. Filter frame; 52. Filter cloth assembly; 521. Filter cloth outer frame; 522. Microporous filter cloth; 523. Filter cloth inner ring; 524. Snap-fit ​​hole; 53. Feed pipe assembly; 531. Fixing plate; 532. Feed pipe; 533. Sliding ring; 534. Telescopic spring; 535. Snap-fit ​​post; 54. Adjustment assembly; 541. Adjusting rod; 542. Adjusting gear; 5 43. Adjusting handwheel; 55. Liquid outlet; 56. Support assembly; 561. Limit block; 562. First support rod; 563. Second support rod; 564. Swing block; 565. Connecting spring; 566. Extension spring; 6. Pressing plate; 7. Telescopic hydraulic cylinder; 8. Drive assembly; 81. Drive motor; 82. Drive gear; 83. Fixing frame; 84. Sliding rack; 85. Sliding groove; 86. Swing frame; 87. Push button; 9. Filter chamber. Detailed Implementation

[0054] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0055] Example 1, referring to Figure 1 - Figure 14 This is the first embodiment of the present invention, which provides a purification device for the production of amoxicillin sodium, including a device frame 1, a drive assembly 8 externally disposed on the adjusting gear 542, multiple filter plate mechanisms 5 disposed inside the device frame 1, and rollers 4 fixedly installed on both sides of the filter plate mechanisms 5. The filter plate mechanisms 5 slide on the top of the device frame 1 via the rollers 4 on both sides. The filter plate mechanism 5 includes a filter frame 51 fixedly connected to the rollers 4, a filter cloth assembly 52 for filtering out filtrate, a feed pipe assembly 53 for conveying fermentation broth, a spreading and supporting assembly 56 for spreading and supporting the filter cloth assembly 52, and an adjusting assembly 54 for adjusting the spreading and supporting assembly 56. The inner wall of the filter frame 51 is provided with a liquid outlet 55, and a pressure filtration chamber 9 is formed between two adjacent filter frames 51.

[0056] Reference Figure 3 - Figure 7 The feed tube assembly 53 includes two fixed plates 531 fixedly connected to the filter frame 51. A feed tube 532 is fixedly connected between the two fixed plates 531. Two symmetrically arranged sliding rings 533 are slidably connected to the outer wall of the feed tube 532. Multiple telescopic springs 534 are fixedly connected between the feed tube 532 and the sliding rings 533. The sliding rings 533 provide guidance for the filter cloth assembly 52 to open. Multiple snap-fit ​​posts 535 are fixedly connected to the outer walls of both the filter frame 51 and the sliding rings 533. The snap-fit ​​posts 535 are used to fix and install the filter cloth assembly 52.

[0057] Specifically, when the support assembly 56 expands the filter cloth assembly 52, the telescopic spring 534 will stretch or compress accordingly, causing the sliding ring 533 to slide on the feed tube 532. The sliding ring 533 provides precise guidance for the filter cloth assembly 52 to expand, ensuring that the filter cloth assembly 52 can be expanded evenly and avoiding local wrinkles or tightness.

[0058] The feed pipe assembly 53 and the feed pipe 532 are channels for transporting fermentation broth. Their function is to accurately transport the fermentation broth to the filter press chamber 9, ensuring that the fermentation broth can smoothly participate in the purification process. The sliding ring 533 is slidably connected to the outer wall of the feed pipe 532 and is connected by a telescopic spring 534. When the spreading assembly 56 spreads the filter cloth assembly 52, the telescopic spring 534 stretches or compresses, causing the sliding ring 533 to slide. The sliding ring 533 provides precise guidance for the spread of the filter cloth assembly 52, allowing the filter cloth assembly 52 to spread evenly, avoiding local wrinkles or tightness, making full use of the filtration area, and improving the filtration effect and efficiency.

[0059] Reference Figure 3 - Figure 5The filter cloth assembly 52 includes a filter cloth outer frame 521 and a filter cloth inner ring 523, as well as a microporous filter cloth 522 fixedly connected between the filter cloth outer frame 521 and the filter cloth inner ring 523. The inner walls of the filter cloth outer frame 521 and the filter cloth inner ring 523 are provided with multiple snap-fit ​​holes 524. The filter cloth assembly 52 is snapped between the filter frame 51 and the sliding ring 533 through the snap-fit ​​holes 524.

[0060] The filter cloth assembly 52 effectively filters the fermentation broth and separates solid impurities, achieving remarkable results. It not only improves the purification quality of amoxicillin sodium and ensures the purity and quality of the product, but also reduces equipment maintenance time and costs due to its easy installation and replacement, thereby increasing production efficiency and providing a strong guarantee for the large-scale production of amoxicillin sodium.

[0061] Reference Figure 3 - Figure 6 The adjustment assembly 54 includes an adjustment rod 541 that is rotatably connected to the filter frame 51 and the feed pipe 532. The adjustment rod 541 extends to the outer wall of the filter frame 51 and is fixedly connected to an adjustment gear 542 and an adjustment handwheel 543.

[0062] With the adjustment component 54, when the adjustment gear 542 is engaged with the sliding rack 84, multiple adjustment rods 541 can be mechanically operated to rotate synchronously; when the adjustment gear 542 is disengaged from the sliding rack 84, one adjustment rod 541 can be manually operated to rotate.

[0063] Reference Figure 6 - Figure 10 The support assembly 56 includes a limiting block 561 fixedly connected to the outer wall of the adjusting rod 541. A first support rod 562 is hinged to the inner wall of the limiting block 561. The first support rod 562 swings inside the limiting block 561. A second support rod 563 is slidably connected to the inner wall of the first support rod 562. An extension spring 566 is fixedly connected between the inner wall of the first support rod 562 and the outer wall of the second support rod 563. The support assembly 56 also includes a swing block 564 hinged to the inner wall of the adjusting rod 541. The swing block 564 swings inside the adjusting rod 541. A connecting spring 565 is fixedly connected between the swing block 564 and the first support rod 562.

[0064] Specifically, the first support rod 562 is connected to the limiting block 561 via a hinge shaft and can swing freely inside the limiting block 561; the first support rod 562 has a hollow structure inside, and the second support rod 563 can slide inside it; the connecting spring 565 can adjust the tension in time according to the relative position change of the swing block 564 and the first support rod 562, thereby further controlling the swing amplitude of the first support rod 562.

[0065] The adjustable component 56 converts the adjustment action of the adjustable component 54 into a force that expands the filter cloth assembly 52. ​​When the operator rotates the adjusting rod 541 by adjusting the gear 542 or the handwheel 543, the limiting block 561 moves accordingly. Through the coordinated action of the first adjustable rod 562, the second adjustable rod 563, the swing block 564, and the connecting spring 565, the power is transmitted and amplified, effectively expanding the filter cloth assembly 52. ​​As a result, the filtration area of ​​the filter cloth assembly 52 is fully utilized, and the fermentation broth can pass through the filter cloth more evenly, improving filtration efficiency and filtration quality, thereby enhancing the purification effect of amoxicillin sodium.

[0066] Reference Figure 13 - Figure 14 The drive assembly 8 includes a fixed frame 83 and a swing frame 86 fixedly connected to the equipment frame 1. A sliding rack 84 is hinged inside the fixed frame 83 and the swing frame 86. Both ends of the sliding rack 84 are provided with sliding grooves 85. The sliding rack 84 slides inside the fixed frame 83 and the swing frame 86 through the sliding grooves 85. A push button 87 is slidably connected to the outer wall of the swing frame 86. The push button 87 is used to adjust the tilt angle of the sliding rack 84. The drive assembly 8 also includes a drive motor 81 fixedly connected to the equipment frame 1. A drive gear 82 is sleeved on the output shaft of the drive motor 81. When the sliding rack 84 is parallel to the ground, it meshes with both the drive gear 82 and the adjusting gear 542.

[0067] Specifically, the sliding rack 84 is installed between the fixed frame 83 and the swing frame 86. It can slide smoothly inside the fixed frame 83 and the swing frame 86, and change the tilt angle under the action of the swing frame 86. The push button 87 is connected to the swing frame 86 through a sliding guide rail, so that the push button 87 can slide smoothly on the outer wall of the swing frame 86. When the push button 87 is pushed, it will change the tilt angle of the sliding rack 84 through the internal transmission mechanism, so as to realize the flexible adjustment of the transmission path.

[0068] Through the drive assembly 8, the drive motor 81 drives the drive gear 82 to rotate. When the sliding rack 84 is parallel to the ground, it meshes with both the drive gear 82 and the adjusting gear 542, thereby transmitting the rotational motion of the drive motor 81 to the adjusting rod 541, which in turn drives the spreading assembly 56 and adjusts the degree of expansion of the filter cloth assembly 52. ​​This reduces the workload of manual operation and improves the automation level of the production process. This makes the purification and production of amoxicillin sodium more efficient and stable, and can meet the needs of large-scale production.

[0069] Reference Figure 1 - Figure 2One end of the equipment frame 1 is fixedly installed with a telescopic hydraulic cylinder 7, and the output end of the telescopic hydraulic cylinder 7 is fixedly connected with a pressure plate 6. Both sides of the pressure plate 6 are connected to rollers 4. The other end of the equipment frame 1 is fixedly installed with a thrust plate 3, and the inside of the thrust plate 3 is fixedly connected with a material conveying pipe 2. The material conveying pipe 2 is connected to the material passing pipe 532 and the filter press chamber 9.

[0070] The pressure plate 6 and thrust plate 3 are set up, and the telescopic hydraulic cylinder 7 pushes the pressure plate 6. The roller 4 makes the pressure plate 6 move more smoothly. The pressure plate 6 and the thrust plate 3 cooperate to apply pressure to the filter frame 51 and other components to form a sealed filtration environment. The feed pipe 2 transports the material to the feed pipe 532 and the filter chamber 9 to achieve material filtration and ensure the efficient solid-liquid separation in the purification production of amoxicillin sodium.

[0071] Example 2, refer to Figure 1 - Figure 14 The second embodiment of the present invention provides a production process for an amoxicillin sodium production purification device, comprising the following steps:

[0072] Step 1: Combine multiple filter plate mechanisms 5, and engage the drive assembly 8 with the adjustment assembly 54;

[0073] Step 2: Input the fermentation broth for the production of amoxicillin sodium, and fill it into each filter press chamber 9 through the feed pipe assembly 53;

[0074] Step 3: Set the pressure of the filter press to initially separate the solid and liquid components in the fermentation broth and obtain the filtrate;

[0075] Step 4: Run the drive component 8, and drive the expansion component 56 to rotate by adjusting component 54, thereby adjusting the filtration pressure and further squeezing out the filtrate in the filter cake in the filter chamber 9;

[0076] Step 5: The filtrate is discharged through outlet 55;

[0077] Step Six: Separate the operation drive component 8 from the adjustment component 54;

[0078] Step 7: Pull out each filter plate mechanism 5 in sequence, and manually operate the adjusting component 54 to drive the spreading and supporting component 56 to rotate, so as to separate the filter cake;

[0079] Step 8: Clean the filter cloth assembly 52.

[0080] Working principle of the invention:

[0081] During operation, the telescopic hydraulic cylinder 7 is first activated. The pressure plate 6 at its output end, in cooperation with the roller 4, pushes multiple filter frames 51 to the thrust plate 3 and tightly closes them. At this time, a filter pressing chamber 9 is formed between two adjacent filter frames 51, and the sealing of the filter pressing chamber 9 is effectively guaranteed. At the same time, the feed pipe 2 is connected to the feed pipe 532 and the filter pressing chamber 9, creating a smooth channel for the delivery of fermentation liquid. Then, the push button 87 is operated to adjust the sliding rack 84 to a state parallel to the horizontal line, so that the sliding rack 84 meshes with the drive gear 82 and the adjusting gear 542 at the same time. Thus, the preliminary work for the subsequent filter pressing operation is completed.

[0082] Next, the fermentation broth used for the production of amoxicillin sodium enters each filter chamber 9 through the feed pipe 2 and the feed pipe 532; the pressure of the filter press is set, and the fermentation broth starts the initial solid-liquid separation process under the pressure; the liquid components in the fermentation broth are filtered through the microporous filter cloth 522 and then discharged from the outlet 55 on the inner wall of the filter frame 51, thereby obtaining the initial filtrate.

[0083] During the filtration process, to prevent uneven accumulation of the filter cake leading to uneven filtration pressure distribution within the filtration chamber 9, the drive motor 81 is activated. Its output shaft drives the drive gear 82 to rotate, and the drive gear 82 drives the adjusting rod 541 to rotate via the sliding rack 84. As the adjusting rod 541 rotates, the limiting block 561 rotates synchronously, thereby causing the first support rod 562 to swing. During this process, the second support rod 563 inside the first support rod 562 extends and retracts under the action of the extension spring 566. The swing block 564 swings inside the adjusting rod 541 and is connected to the first support rod 562 via the connecting spring 565. This together adjusts the support force, causing the microporous filter cloth 522 to expand outward under the guidance of the sliding ring 533, squeezing the unevenly distributed filter cake in the filtration chamber 9 and further squeezing out the filtrate from the filter cake. After pressure adjustment, the squeezed filtrate is continuously discharged through the outlet 55 until the entire filtration process is completed.

[0084] Operate push button 87 to tilt sliding rack 84, disconnect sliding rack 84 from adjusting gear 542, retract telescopic hydraulic cylinder 7, pull open each filter frame 51 in sequence, manually operate adjusting handwheel 543 to drive support assembly 56 to rotate, causing filter cake to separate from filter cloth assembly 52.

[0085] The filter cloth assembly 52 is separated for cleaning. Since the filter cloth assembly 52 is snapped between the filter frame 51 and the sliding ring 533 through the snap-fit ​​hole 524 and the snap-fit ​​post 535, the replacement and cleaning operation is simple, ensuring the continuity and stability of production.

[0086] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.

Claims

1. A purification device for the production of amoxicillin sodium, comprising a device frame (1), a drive assembly (8) disposed outside the device frame (1), a plurality of filter plate mechanisms (5) disposed inside the device frame (1), and rollers (4) fixedly installed on both sides of the filter plate mechanisms (5), wherein the filter plate mechanisms (5) slide on the top of the device frame (1) via the rollers (4) on both sides, characterized in that: The filter plate mechanism (5) includes a filter frame (51) fixedly connected to the roller (4), a filter cloth assembly (52) for filtering out filtrate, a feed pipe assembly (53) for conveying fermentation liquid, a spreading and supporting assembly (56) for spreading the filter cloth assembly (52), and an adjusting assembly (54) for adjusting the spreading and supporting assembly (56). The inner wall of the filter frame (51) is provided with a liquid outlet (55), and a filter press chamber (9) is formed between two adjacent filter frames (51). The feed tube assembly (53) includes two fixed plates (531) fixedly connected to the filter frame (51), a feed tube (532) fixedly connected between the two fixed plates (531), two symmetrically arranged sliding rings (533) slidably connected to the outer wall of the feed tube (532), a plurality of telescopic springs (534) fixedly connected between the feed tube (532) and the sliding rings (533), the sliding rings (533) providing guidance for the filter cloth assembly (52) to open, and a plurality of snap-fit ​​posts (535) fixedly connected to the outer walls of both the filter frame (51) and the sliding rings (533), the snap-fit ​​posts (535) being used to fix and install the filter cloth assembly (52); The filter cloth assembly (52) includes a filter cloth outer frame (521) and a filter cloth inner ring (523), and a microporous filter cloth (522) fixedly connected between the filter cloth outer frame (521) and the filter cloth inner ring (523). The inner walls of the filter cloth outer frame (521) and the filter cloth inner ring (523) are provided with a plurality of snap-fit ​​holes (524). The filter cloth assembly (52) is snapped between the filter frame (51) and the sliding ring (533) through the snap-fit ​​holes (524). The adjustment assembly (54) includes an adjustment rod (541) rotatably connected to the filter frame (51) and the feed tube (532). The adjustment rod (541) extends to the outer wall of the filter frame (51) and is fixedly connected to an adjustment gear (542) and an adjustment handwheel (543). The support assembly (56) includes a limiting block (561) fixedly connected to the outer wall of the adjusting rod (541). The inner wall of the limiting block (561) is hinged to a first support rod (562). The first support rod (562) swings inside the limiting block (561). The inner wall of the first support rod (562) is slidably connected to a second support rod (563). An extension spring (566) is fixedly connected between the inner wall of the first support rod (562) and the outer wall of the second support rod (563).

2. The purification equipment for the production of amoxicillin sodium according to claim 1, characterized in that: The support assembly (56) further includes a swing block (564) hinged to the inner wall of the adjusting rod (541). The swing block (564) swings inside the adjusting rod (541). A connecting spring (565) is fixedly connected between the swing block (564) and the first support rod (562).

3. The purification equipment for the production of amoxicillin sodium according to claim 1, characterized in that: The drive assembly (8) includes a fixed frame (83) and a swing frame (86) fixedly connected to the equipment frame (1). The fixed frame (83) and the swing frame (86) are hinged with a sliding rack (84). Both ends of the sliding rack (84) are provided with sliding grooves (85). The sliding rack (84) slides inside the fixed frame (83) and the swing frame (86) through the sliding grooves (85). The outer wall of the swing frame (86) is slidably connected with a push button (87). The push button (87) is used to adjust the tilt angle of the sliding rack (84).

4. The purification equipment for the production of amoxicillin sodium according to claim 3, characterized in that: The drive assembly (8) also includes a drive motor (81) fixedly connected to the equipment frame (1). The output shaft of the drive motor (81) is fitted with a drive gear (82). When the sliding rack (84) is parallel to the ground, it meshes with both the drive gear (82) and the adjusting gear (542).

5. The purification equipment for the production of amoxicillin sodium according to claim 1, characterized in that: One end of the equipment frame (1) is fixedly installed with a telescopic hydraulic cylinder (7), and the output end of the telescopic hydraulic cylinder (7) is fixedly connected with a pressure plate (6). Both sides of the pressure plate (6) are connected to rollers (4).

6. The purification equipment for the production of amoxicillin sodium according to claim 1, characterized in that: A thrust plate (3) is fixedly installed at the other end of the equipment frame (1). A conveying pipe (2) is fixedly connected inside the thrust plate (3). The conveying pipe (2) is connected to the feed pipe (532) and the filter press chamber (9).

7. A production process applied to a purification equipment for amoxicillin sodium production, employing the purification equipment for amoxicillin sodium production as described in claim 1, characterized in that... Includes the following steps: Step 1: Combine multiple filter plate mechanisms (5), and engage the drive assembly (8) with the adjustment assembly (54); Step 2: Input the fermentation broth for the production of amoxicillin sodium, and fill it into each filter press chamber (9) through the feed pipe assembly (53); Step 3: Set the pressure of the filter press to initially separate the solid and liquid components in the fermentation broth and obtain the filtrate; Step 4: Run the drive assembly (8), and drive the support assembly (56) to rotate by adjusting the assembly (54), adjust the filtration pressure, and further squeeze out the filtrate in the filter cake in the filter chamber (9); Step 5: The filtrate is discharged through the outlet (55); Step 6: Separate the operation drive component (8) from the adjustment component (54); Step 7: Pull out each filter plate mechanism (5) in sequence, and manually operate the adjustment component (54) to drive the support component (56) to rotate, so as to separate the filter cake; Step 8: Separate the filter cloth assembly (52) and clean it.

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