Conveying device, conveying system and pipetting system

Abstract

The invention relates to a transfer apparatus, a transfer system and a pipetting system. A transfer apparatus (40) for introducing a pipette carrier (41) into a pipetting device (42) comprises a comb-like structure (43) having an elongate base (44) and a plurality of teeth (45, 46) arranged perpendicular thereto, where the teeth are arranged parallel and equidistant with respect to one another and comprising two outer teeth (45) and a plurality of inner teeth (46) arranged between the outer teeth (45), where the inner teeth (46) and the outer teeth (45) are spaced apart from one another. The elongated base (44) and the two outer teeth (45) are implemented in the form of a three-sided frame (47) wherein the comb-like structure (43) has an upper side (57) and a lower side (58) wherein the height of the inner teeth (46) on the lower side (58) is reduced such that the height of the inner teeth (46) gradually decreases from the elongated base (44) to an end (46a) of the inner teeth (46) remote from the elongated base (44). Furthermore, the invention relates to a transfer system (55) and a pipetting system (80).

Description

Technical Field

[0001] This invention relates to a transfer device for introducing a pipette carrier filled with a pipette tip into an automated pipette machine, a transfer system including the transfer device and the pipette carrier, and a pipetting system including the transfer system and the automated pipetting machine. The pipette tip has a distal region and a proximal region with a collar. Background Technology

[0002] Repetitive tasks in laboratories are increasingly being taken over by automated laboratory equipment. Particularly for biochemical analysis in the chemical and pharmaceutical fields, there is a desire for automated systems to handle liquid samples. Thus, so-called liquid handling systems are used for sample preparation and / or for analytical preparation. Such laboratory equipment is also known by terms such as pipetting robots and pipetting and analytical devices. Tasks performed by these pipetting devices specifically include supplying and removing defined volumes of liquid from laboratory components to, for example, by supplying reagents to initiate biochemical reactions, and preparing samples for subsequent measurements in analytical devices, such as, for example, preparation in the form of dried samples. Analytical devices include all equipment for determining at least one chemical and / or physical characteristic of a sample, examples of which are devices for spectroscopic methods and spectroscopy, as well as pH and conductivity probes and other equipment.

[0003] Corresponding automated pipetting devices include at least one pipette, typically multiple pipettes arranged in a pipette tip, sometimes with replaceable pipette tips. Simple automated pipetting devices or dispensing devices dispense only a limited volume of liquid, while in larger automated pipetting devices, the pipette tip can move in two or three spatial directions. More complex automated pipetting devices often perform additional tasks, such as the transport and handling of laboratory components, as well as sample mixing and incubation.

[0004] A pipette is used to aspirate and release a defined volume of liquid. Generally, pipettes are designed so that liquid does not reach the interior of the pipette. Instead, the pipette tip is placed on the end region of the pipette, and the liquid is contained within the pipette tip. In the case of a manual pipette with only one pipetting channel, the aspiration and release of a defined volume of liquid into and out of the pipette tip is controlled by applying appropriate negative or positive pressure; the end region of the pipette is generally conical or axial. In this case, the pipette tip is connected to the end region of the pipette by force interlocking (e.g., friction interlocking) and is further secured in part by a sealing element (e.g., an O-ring).

[0005] Multichannel pipetting devices enable the simultaneous processing of multiple volumes. Instead of a single pipetting channel, these pipetting channels have several or more pipetting channels. Such multichannel pipetting devices are known from DE202008013533 U1. In this case, a defined volume of liquid, for example, from 4 to 384 samples, can be moved simultaneously. The pipetting channels are disposed in a substrate. As an alternative to mounting the pipette tip on the conical or axial end region of the pipette in the case of a multichannel pipette, a sealing plate with elastic properties is typically used. The pipette tip is pressed against the sealing plate using a defined force. The sealing plate terminates the substrate and guides the pipetting channels similarly to the substrate. The active pressing of the pipette tip against the sealing plate ensures that, when a negative pressure is applied, a defined volume of liquid is drawn into the pipette tip and held there until the liquid is released. In the case of multiple pipetting channels and corresponding multiple pipette tips, each pipette tip is sealed by means of the sealing plate.

[0006] Pipette tips are typically provided in a so-called loader. The loader is generally a planar, curved, rigid plate with channels in which the pipette tip is housed. This loader, filled with the pipette tip, is then moved in the direction of a sealing plate, causing the pipette tip to press against the sealing plate. Ideally, in this case, the longitudinal axis of the pipette tip is arranged parallel to the cross-sectional plane of the sealing plate to achieve optimal sealing of the pipette tip. Such a loader is disclosed, for example, in DE202020100836 U1.

[0007] Loaders are typically used only once and then disposed of, which means high material consumption and costs. Summary of the Invention

[0008] Therefore, the object of the present invention is to provide a transfer device, transfer system and pipetting system that saves materials compared with conventional solutions.

[0009] According to the present invention, this objective is achieved by a transfer device, a transfer system, and a pipetting system.

[0010] Regarding the transfer device, this objective is achieved according to the invention by using a transfer device for introducing a pipette carrier into a pipetting apparatus, comprising:

[0011] A comb-like structure having an elongated base and a plurality of teeth arranged perpendicular to the elongated base, wherein the teeth are arranged parallel to each other and equidistantly and include two outer teeth and a plurality of inner teeth arranged between the outer teeth, wherein the elongated base and the two outer teeth are implemented in the form of a three-sided frame, wherein the comb-like structure has an upper side and a lower side.

[0012] - In this case, the height of the internal teeth on the lower side is reduced, so that the height of the internal teeth gradually decreases from the slender base to the end of the internal teeth away from the slender base.

[0013] The transfer device can be reused, while the pipette carrier, such as a single-plate or double-plate support, is generally used only once. Instead of disposing of the entire loader, only the pipette carrier needs to be disposed of, and the transfer device can be reused. In this way, materials and costs are saved. The transfer device can be manufactured by injection molding and, for example, made of plastic. The transfer device can also be made of metal or metal alloy or include at least one metal. The transfer device can be implemented as a single piece. In particular, the comb-like structure is connected to the frame and holding element by continuous material. Internal teeth can be implemented to hold the pipette carrier.

[0014] By reducing the height of the internal teeth, the geometry of the transfer device can be optimized when the pipette carrier is introduced into the transfer device. In particular, the reduction in height compensates for errors in the manufacturing tolerances of the pipette carrier.

[0015] In one embodiment, the height of the internal tooth on the lower side is reduced such that when a force is applied to the internal tooth, the internal tooth deforms at most until the lower side of the internal tooth approaches or reaches a horizontal position.

[0016] In another embodiment, the height of the internal teeth is reduced such that the height of the internal teeth is reduced at an angle between 0.05° and 3°.

[0017] In another embodiment, the transfer device includes at least one retaining element arranged on a frame and configured such that the pipette carrier can be locked within the transfer device along at least one axis. Locking prevents the pipette carrier from sliding within the transfer device, particularly during transfer or during the introduction of the transfer device into the pipette apparatus. The retaining element is preferably oriented along the direction of a comb-like structure. The comb-like structure may have an upper side and a lower side. Preferably, at least one retaining element is disposed on the upper side.

[0018] In one embodiment, at least one retaining element is an eave, a recess, a protrusion, and / or a notch.

[0019] In particular, at least one retaining element is implemented as a radial segment or a circular segment.

[0020] In an alternative embodiment, at least one retaining element includes a spring, a magnet, and / or a rotating element.

[0021] In further developments, the conveying device includes a handle arranged on an elongated base. The handle is particularly used for holding the conveying device by an operator or robot.

[0022] Preferably, the handle includes a centering element, particularly an opening, which is configured to enable movement of the conveying device by an automated means. For example, a robot can engage in the centering element to hold and transport the conveying device.

[0023] In one embodiment, the frame includes a frame recess located in a region of the elongated base and particularly centrally disposed on the elongated base.

[0024] Preferably, the frame recess is implemented such that the frame is lowered by the frame recess to the height of the handle. Preferably, the frame recess extends substantially over the width of the handle. In particular, the frame recess can mate with the gripping portion or gripping element of a pipette carrier, especially a single-plate or double-plate support. The frame recess can be implemented such that the gripping element or gripping part of the pipette carrier can be introduced into the frame recess. Thus, an operator or robot can grip the gripping element or gripping part in the frame recess and release the pipette carrier from the transfer device by applying force in the direction below the comb structure, and thus remove the pipette carrier from the transfer device.

[0025] In another embodiment, the frame includes at least two orientation elements configured to allow the delivery device to be introduced into the pipetting apparatus via an automated means. The orientation elements guide the delivery device into the pipetting apparatus.

[0026] In a further development, the frame includes at least one peripheral guide groove. The at least one guide groove supports the insertion of a pipette carrier into the delivery device, as the pipette carrier is guided within the guide groove. The at least one guide groove can be positioned above or below the comb-like structure. For example, the lower and / or upper plates of a double-plate support can engage in at least one guide groove.

[0027] In one embodiment, the frame includes at least one stop surface disposed at least along an elongated base and at the same height as the upper edge of the internal teeth or between the teeth. Specifically, the stop surface disposed at the same height as the upper edge of the internal teeth is capable of extending around the frame. The stop surface is used to guide the pipette carrier upon introduction into the delivery device.

[0028] In one embodiment, the frame includes a gripping element, such as, for example, a flange, edge, or surface, by means of which force is applied on the delivery device, particularly in the direction above the comb-like structure. The pipetting device is able to apply force on the delivery device by means of the gripping element to seal the pipetting tip against a sealing plate.

[0029] Preferably, the internal teeth have an engaging element, particularly an edge or flange, at one of their ends away from the elongated base, by means of which force is applied on the transfer device. The flange or edge is used to apply force on the transfer device, particularly by means of a pipetting device. This force is applied, in particular, from the lower side of the comb-like structure in the direction above it. The connection between the engaging element and the slab support (which generally does not have an application point for applying force) is particularly important. Preferably, by means of the engaging element and gripping element of the transfer device, a force is generated for sealing the pipetting tip in the slab support within the pipetting device.

[0030] In one embodiment, the internal teeth have a tapered cross-section that tapers towards the top. The tapered cross-section is used to better transmit force from the pipette to the delivery device. In this way, force applied from the bottom of the comb-like structure in the direction above the comb structure can be advantageously transmitted to the top of the comb structure, ensuring a reliable seal between the pipette tip collar and the sealing plate of the pipetting device.

[0031] In one embodiment, the tapered cross-section is fabricated such that it matches the outer diameter of the pipette tip across the entire height of the internal teeth. In this embodiment, force loss during force transmission from the pipette to the delivery device is minimized.

[0032] In one embodiment, at least one internal tooth has a greater length than at least one other internal tooth. The greater length of the internal tooth facilitates the introduction of the pipette carrier into the delivery device, particularly as the pipette carrier and the pipette tip within the carrier pass between the internal teeth.

[0033] In one embodiment, the inner teeth gradually lengthen from the outer teeth to the middle of the comb-like structure.

[0034] In another embodiment, one or two inner teeth in the middle of the comb-like structure are shorter than the teeth around them.

[0035] In further development, one or two internal teeth became longer than the rest.

[0036] Regarding the transmission system, this objective is achieved by the transmission system according to the present invention, the transmission system comprising...

[0037] - Pipette carriers, especially double-plate or single-plate supports, and

[0038] -A transmission device according to one of the foregoing embodiments,

[0039] The pipette carrier can be introduced into the transfer equipment.

[0040] The pipette carrier includes at least one plate having multiple channels or openings for holding pipette tips. The channels or openings can be configured to hold pipette tips. The pipette carrier can be configured as a double-plate support or a single-plate support. The pipette carrier can be introduced into a transport device. The pipette carrier can be introduced into the transport device by means of internal teeth. Specifically, the internal teeth guide the pipette tips within the pipette carrier. The transport system can include multiple pipette tips introduced into the pipette carrier. Optionally, in addition to the transport device, the transport system can also include a support system or support device.

[0041] The embodiment provides that the pipette carrier is a double-plate support, and the distance between the supports is implemented such that the transfer device can be engaged between the supports by means of internal teeth and maintain the double-plate support.

[0042] An alternative embodiment provides that the pipette carrier is a single-plate support, and the distance between the orientation elements is implemented such that the delivery device can engage between the orientation elements by means of internal teeth and hold the single-plate support.

[0043] In one embodiment, the delivery device includes at least one retaining element, and the pipette carrier includes at least one locking element, which is configured to correspond to the retaining element.

[0044] The pipette carrier can be introduced into the transfer device and locked in the transfer device by means of at least one locking element and at least one retaining element. The at least one locking element can be attached to a plate. The at least one retaining element and the at least one locking element can be implemented such that locking of the pipette carrier and the transfer device is achieved by means of form interlocking or pin-based engagement.

[0045] Regarding the pipetting system, this objective is achieved by means of the pipetting system according to the present invention.

[0046] -A transmission system according to one of the foregoing embodiments, and

[0047] - A pipetting device having a pipetting tip with a sealing plate and multiple pipetting channels for drawing liquid into and out of the pipetting tip, wherein the pipetting channels are guided through the sealing plate.

[0048] The transfer system can be incorporated into the pipetting device, and the pipetting device is adapted to apply force on the transfer equipment so that the pipetting tip arranged in the pipetting carrier is sealed against the sealing plate. Attached Figure Description

[0049] The invention will now be explained in more detail with reference to the accompanying drawings. Figures 1-33 As shown below:

[0050] Figures 1-3 This is the first embodiment of the double-plate support of the present invention.

[0051] Figure 4 This is the second embodiment of the double-plate support of the present invention.

[0052] Figure 5 This is a plan view of the upper plate of the double-plate support member of the present invention.

[0053] Figure 6 for Figure 5 Detailed images.

[0054] Figures 7-8 This is an embodiment of the support system of the present invention.

[0055] Figure 9 This is a cross-sectional view of the support system of the present invention.

[0056] Figure 10 This is another embodiment of the double-plate support of the present invention.

[0057] Figure 11 This is another embodiment of the support system of the present invention.

[0058] Figures 12-13 This is an embodiment of the single-plate support component of the present invention.

[0059] Figures 14-15 Two other embodiments of the single-plate support of the present invention are shown.

[0060] Figures 16-17 This is an embodiment of the support device of the present invention.

[0061] Figure 18 This is the first embodiment of the transmission device of the present invention.

[0062] Figure 19 This is a second embodiment of the transmission device of the present invention.

[0063] Figure 20 This is the first embodiment of the transmission system of the present invention.

[0064] Figures 21a-22 This is the third embodiment of the transmission device of the present invention.

[0065] Figures 23a-23c This is the fourth embodiment of the transmission device of the present invention.

[0066] Figure 24 This is the fifth embodiment of the transmission device of the present invention.

[0067] Figures 25-27 This is an embodiment of the conveying system of the present invention with a single-plate support member.

[0068] Figures 28-29 Another embodiment of the conveying system of the present invention with a single-plate support is shown.

[0069] Figures 30-31 This is an embodiment of the conveying system of the present invention having a double-plate support.

[0070] Figures 32-33 These are two embodiments of the pipetting system of the present invention.

[0071] The embodiments of the different devices and apparatuses described in the accompanying drawings are combinable with each other to a desired degree. This is particularly true of the examples of the transmission devices of the present invention, many of which are shown based on several figures and whose embodiments can be combined to a desired degree. Detailed Implementation

[0072] Figures 1-3 A double-plate support 1 is illustrated by way of example in different views. The double-plate support 1 comprises an upper plate 3 and a lower plate 4, which are arranged substantially parallel to each other and are implemented, in particular, to resist bending. The upper plate 3 includes a plurality of first channels 5, and the lower plate 4 includes a plurality of second channels 6. The first channels 5 and the second channels 6 are implemented and arranged in a manner that they are aligned with each other. In particular, the first channels 5 and the second channels 6 are aligned with each other such that the centers of the first channels 5 and the aligned centers of the second channels 6 are arranged on a common transverse axis 1a of the double-plate support. In the sense of the invention, multiple components mean the presence of two or more components. Preferably, the number of first channels 5 is equal to the number of second channels 6. The number of first channels 5 and second channels 6 can be equal to the number of typical microtiter plates and follows the established ANSI-SLAS standard. For example, a double-plate support can have 96 or 384 first channels 5 and 96 or 384 second channels 6. Alternative forms of embodiments of the double-plate support 1, and particularly the diameters of the first channels 5 and the second channels 6, are... Figure 10 As shown in the diagram. The first channel 5 and the second channel 6 can be implemented circularly; however, they can also have other forms, such as, for example, as... Figure 6As shown. The diameters of the first channel 5 and the second channel 6 can be the same; however, generally, the diameters of the first channel 5 and the second channel 6 are offset from each other, such that the diameter of the first channel 5 is larger than the diameter of the second channel 6. This follows the common shape of a pipette tip that tapers from the collar 2c to the distal region 2a. The upper plate 3 and the lower plate 4 are connected together by means of a sidewall 7, which in each case is arranged along the first long sides 3a, 4a of the upper plate 3 and the lower plate 4. The sidewall 7 can extend along the entire length of the first long side 3a or only along one or more segments of the first long side 3a.

[0073] To ensure the stability of the double-plate support 1, multiple support rods 8 are arranged between the upper plate 3 and the lower plate 4, connecting the upper plate 3 and the lower plate 4 to each other. The support rods 8 can be cylindrical, prismatic, or conical, with other embodiments also possible. The support rods 8 can be arranged between the center 3b of the upper plate 3 and the second long side 3c of the upper plate 3 opposite to the first long side 3a. The support rods 8 can be arranged symmetrically or asymmetrically between the upper plate 3 and the lower plate 4. In particular, the support rods 8 can be arranged equidistantly relative to each other and / or on an axis parallel to the first long side 3a of the upper plate 3. The distance between the support rods 8 can be selected such that, particularly after the double-plate support 1 is filled with pipette tips 2, the transfer device 40 can be assembled between the support rods 8, and particularly between the pipette tips 2, and maintain the double-plate support 1 (comparatively...) Figures 30-31 ).

[0074] For a simple and material-reducing embodiment of the double-plate support 1, the material-reducing portion 12 can be designed into the lower plate 4 and / or the upper plate 3. The material-reducing portion 12 is specifically designed to reduce the material used in the lower plate 4 and / or the upper plate 3. The material-reducing portion 12 can be implemented as, for example, a recess, a hole, or an opening. In this case, the material-reducing portion 12 is arranged between the second channel 6 and / or the first channel 5. Specifically, the material-reducing portion 12 is not aligned with the first channel 5 or the second channel 6. Figures 1 to 4 In the example, the material reduction section 12 is implemented as the third channel of the lower plate 4.

[0075] In addition to connecting the upper plate 3 and the lower plate 4, the side wall 7 can also have other functions. Therefore, the side wall 7 can have one or more gripping elements 13 arranged on the side of the side wall 7 away from the support rod 8 and configured such that the double-plate support 1 can be held by an automated device using one or more gripping elements 13. Specifically, the one or more gripping elements 13 are implemented as object holders. Figures 2-3Three gripping elements 13 are shown as an example, wherein the middle gripping element is a flat plate, and the two outer gripping elements are object holders implemented as channels. Such gripping elements 13 can be easily gripped by conventional robots (especially Cartesian robots), so that the double-plate support 1 can be held and transported by means of gripping elements 13 using automated devices.

[0076] Furthermore, the sidewall 7 may have a code area 15, which has at least one code element 16, based on which the double-plate support 1 is identifiable. For example, the number of first and second channels 5, 6 in the double-plate support 1 can be detected by means of at least one code element 16. The at least one code element 16 may be, for example, a QR code, barcode, RFID tag, or some other write-in. Additionally, the sidewall 7 may have at least one force input element 14, such as, for example, an edge, protrusion, flange, and / or surface, by means of which force is applied to the double-plate support 1. After the double-plate support 1 is placed in the pipette, force can be applied, particularly by means of the pipette. This force can be used to press the double-plate support 1 against the sealing plate of the pipette so as to seal the pipette tip 2 against the sealing plate. The force is applied, particularly to the force input element 14, in the direction from the lower plate 4 to the upper plate 3.

[0077] To prevent the double-plate support 1 in the pipetting device 42 from tilting without completely filling the pipette tip 2, at least one spacer 11 can be arranged on the upper plate 3 in a region away from the lower plate 4. The at least one spacer 11 can be cylindrical, conical, or prismatic. Preferably, the upper plate 3 has a plurality of spacers 11, such as, for example, in… Figure 4 As shown in the image.

[0078] Figure 5 A plan view of the upper plate 3 of the double-plate support 1 of the present invention is shown. A second channel 6 in the lower plate 4 is visible within the first channel 5, which in this example has a smaller diameter than the first channel 5. The first channel 5 can be implemented such that its boundary 9 (shown in dashed lines) serves as a support surface for the collar 2c of the inserted pipette tip 2. Alternatively, the upper plate 3 can have multiple support elements that serve as support surfaces for the collar 2c of the pipette tip 2. An example of such a support element 26 using the single-plate support 20 is shown in... Figure 13 As shown, and also usable in the case of a double-plate support 1. The first channel 5 and / or the second channel 6 can be implemented as circular or have at least two radial segments 10. Figure 6This embodiment is illustrated in detail. Preferably, the first channel 5 and / or the second channel 6 have two or four radial segments 10. In particular, the first channel 5 and the second channel 6 are configured such that a pipette tip introduced into the first channel 5 and the second channel 6 is held in a predetermined position within the first channel 5 and the second channel 6. At least one locking element 30 may be arranged on the upper plate 3 and / or the lower plate 4. An example using a single-plate support 20 is shown in... Figure 12 An example of such a locking element is shown; the illustrated locking element 30 is also applied to a double-plate support. Preferably, at least one locking element 30 is arranged on the upper plate 3, particularly on the transverse edge of the upper plate 3. In this way, at least one locking element can be locked with at least one retaining element 48 of the conveying device, such as, for example, in... Figure 18 or Figure 19 As shown in the image.

[0079] Figures 7-9 The support system 17 of the present invention is shown. The support system 17 includes a double-plate support 1 and a plurality of pipette tips 2, each having a distal region 2a, a proximal region 2b, and a collar 2c, and being introduced into a first channel 5 and a second channel 6, such as... Figure 8 As shown in the image. Figure 7 The support system 17 is shown in an exploded view. Figure 9 A cross-section through the support system 17 is shown. The first channel 5 and the second channel 6 can be configured such that the pipette tip 2 is oriented along the transverse axis 1a of the double-plate support 1. The transverse axis 1a of the double-plate support 1 is particularly transverse to the first long sides 3a and 4a of the upper plate 3 and the lower plate 4. The number of pipette tips 2 can be equal to or less than the number of the first channels 5.

[0080] Figure 10 Another embodiment of the double-plate support 1 is shown. In this variation, the first channel 5 and the second channel 6 are sized smaller than those in the previous embodiment. Accordingly, the double-plate support 1 is able to hold significantly more pipette tips. Figure 11 It shows the use of Figure 10 Another embodiment of the support system 17 of the present invention is the double-plate support member 1.

[0081] Figure 12 and Figure 13 The single-plate support 20 of the present invention is shown schematically. The single-plate support 20 includes a plate 21 having a top edge 31, a bottom edge 32 and a plurality of openings 22. Figure 12 The view shown below 32 is as follows, and Figure 13A view of the upper side 31 is shown. The plate 21 is specifically designed to be resistant to bending. The opening 22 is specifically a channel. In each case, the opening 22 can be configured to hold a pipette tip. The number of openings 22 can be matched to the number of typical microtiter plate formats and follows established ANSI-SLAS standards. For example, a single-plate support can have 96 or 384 openings 22. A plurality of directional elements 23 are arranged on the lower side 32 of the plate 21, the directional elements 23 at least partially surrounding the openings 22. The directional elements 23 can at least partially surround the openings 22, particularly along the periphery or edge of the openings 22. The directional elements 23 are specifically configured to orient a pipette tip 2 placed in the opening 22 along the transverse axis 20a of the single-plate support 20. The transverse axis 20a of the single-plate support 20 is particularly transverse to the plate 21. The openings 22 and / or the directional elements 23 can be implemented cylindrically or conically or have at least two radial segments 24. At least two radial segments 24 can be arranged symmetrically or mirror-symmetrically. Figure 12 In the example, the directional element 23 is implemented in each case as two radial segments 24. Three, four, or more radial segments can also be used as the directional element 23. Possible embodiments of the opening 22 can be derived from... Figure 6 ;exist Figure 6 In the middle, the first channel 5 corresponds to the opening 22. A reinforcing element 34, such as a rib, can be arranged on the surface of the directional element 23 away from the opening 22. The distance between the directional elements 23 can be selected such that, particularly after filling the veneer support 20 with the pipette tip 2, the transfer device 40 can extend between the directional elements, and particularly between the pipette tips 2, and hold the veneer support 20 (compared to...) Figures 25-27 ).

[0082] Furthermore, multiple support elements 26 can be arranged on the upper 31, which in each case serve as a support surface for the collar 2c of one of the pipette tips 2 disposed in the opening 22. The support elements 26 can be cylindrical, or have at least two radial segments 24, particularly arranged point-symmetrically or mirror-symmetrically. By means of the support elements 26, the pipette tip 2 is prevented from resting directly on the plate, thus requiring the plate to be constructed more robustly. The support elements 26, in particular, at least partially surround the opening 22.

[0083] The veneer support 20 may have at least one gripping portion 27, which is particularly arranged on the long side 21a of the veneer 21. Preferably, the veneer support 20 has two gripping portions, which are arranged on each long side of the veneer 21, such as... Figure 12As shown. At least one gripping part 27 may have an identification area 28, which has at least one identification element 29, based on which the single-board support 20 is identifiable. The at least one identification element 29 may be, for example, a QR code, barcode, RFID tag, or other write-in.

[0084] The plate 21 may have at least one locking element 30, which is particularly arranged on the transverse edge 21b of the plate 21. The at least one locking element 30 is used to lock the single plate support 20 in the conveying device 40 along at least one axis. The at least one locking element 30 may be implemented as a snap, notch, cavity and / or flange. Figure 12 and Figure 13 Two different locking elements 30 are shown. Thus, a snap fastener 30a is arranged at each end of the transverse edge 21b of the plate 21, and a recess 30b formed by two protrusions is located at the center of the transverse edge 21b. The two snap fasteners 30a are specifically used to lock the veneer support 20 in the plane of the plate 21, while the recess is used to lock the veneer support 20 transversely to the plate 21.

[0085] Figure 14 and Figure 15 Two other embodiments of the single-plate support 20 of the present invention are shown. For example... Figure 14 As shown, the single-plate support 20 can have multiple material reducers 36 in the form of, for example, recesses or holes on the plate 21. The multiple material reducers 36 are arranged between the openings 22. Figure 15 As shown, the single-plate support 20 can have at least one spacer 35 on the upper edge of the plate 21. The at least one spacer 35 is arranged in particular between the openings 22.

[0086] Figure 16 and Figure 17 The support device 33 of the present invention is shown, which includes a single plate support 20 and a plurality of pipette tips 2 placed in an opening 22. Figure 16 The support device 33 is shown in an exploded view. The directional elements 23 can be implemented to orient the pipette tips 2 in the openings 22, particularly oriented along the transverse axis 20a of the veneer support 20. The number of pipette tips 2 can be equal to or less than the number of openings 22.

[0087] Figure 18A first embodiment of the transfer device 40 of the present invention is shown. The transfer device 40 has a comb-like structure 43 having an elongated base 44 and a plurality of vertically arranged teeth 45 and 46, which are parallel to each other and equidistantly arranged. The teeth 45 and 46 include two outer teeth 45, which together with the elongated base 44 form a three-sided frame 47. Arranged between the outer teeth 45 are a plurality of inner teeth 46. The inner teeth 46 are capable of holding the pipette carrier 41. The comb-like structure 43 can have an upper side 57 and a lower side 58. In addition, the transfer device 40 can have at least one holding element 48, which is arranged on the frame 47 and implemented such that the pipette carrier 41 can be locked in the transfer device 40 along at least one axis. The at least one holding element 48 is particularly implemented as an eave, a recess, a protrusion, and / or a notch. Figure 18 The diagram shows two types of retaining elements 48: an eave 48a and a notch 48b. The eave 48a is used to lock the pipette carrier 41 in the transfer device 40 along an axis transverse to the frame 47. The notch 48b is used to lock the pipette carrier 41 in the plane of the frame 47. At least one retaining element 48 can be implemented as a radial segment or a circular segment. For example, the eave 48b is implemented as a circular segment. Alternatively, at least one retaining element 48 can have a spring, a magnet, and / or a rotating element. Figure 19 The retaining element 48 is shown as a radial segment 48c.

[0088] The conveying device 40 may have a handle 50 arranged on an elongated base 44 and, in particular, a centering element 51, which is implemented to enable the conveying device 40 to be moved by an automated device. Figure 18 A centering element 51 with an opening is shown as an example implementation. With the aid of the centering element 51, the robot is able to grasp and move the conveyor 40. Furthermore, the operator can hold and transport the conveyor 40 using the handle 50.

[0089] The frame 47 may have a frame recess 49, particularly centrally located on the elongated base 44, in the region of the elongated base 44. The frame recess 49 may be configured such that it descends to the height of the handle 50. The frame may also have at least one stop surface 54, which is arranged at least along the elongated base 44 and at the same height as the upper edge of the internal teeth 46 or between the teeth 45 and 46. The stop surface 54 is used to receive the pipette carrier 41. The stop surface 54 may be arranged along the frame 47. In this case, the stop surface 54 may guide the pipette carrier 41 when it is introduced into the transfer device 40.

[0090] The internal tooth 46 may have an engagement element 60, particularly an edge or flange, at its end 46a away from the elongated base. The engagement element 60 can be used to apply force to the transfer device 40, particularly by means of the pipetting device 42. This force is particularly applied in the direction from the lower side 58 of the internal tooth 46 toward the upper side 57. Figure 19 A connecting element 60 implemented as a flange is shown.

[0091] The transfer device 40 is particularly suitable for the pipetting apparatus 42, and is configured such that the transfer device 40 is placed horizontally, particularly inserted into the pipetting apparatus 42. An alternative pipetting apparatus is configured such that the transfer device 40 is picked up vertically through the upper edge 57 of the comb-like structure 43. For this purpose, the transfer device 40 can have at least two orientation elements 52, such as... Figure 19 As shown, these orientation elements are implemented such that the transfer device 40 can be automatically introduced into the pipetting device 42. The pipetting device 42 may have a pipetting head 72 that is movable along the z-axis, and thus can be moved downwards onto the transfer device and positioned on the transfer device 40. In this case, at least two orientation elements 52 are used to guide the pipetting head 72.

[0092] Figure 20 An embodiment of the delivery system 55 of the present invention is shown in plan view of the upper side 57 of the comb-like structure 43, which has a delivery device 40 and a pipette carrier 41. The delivery system 55 can include a plurality of pipette tips 2 introduced into the pipette carrier 41. Figure 20 The pipette carrier 41 shown is a single-plate support 20; however, it can also be a double-plate support 1, or, in a given case, some other pipette carrier 41. The pipette carrier 41 can have at least one locking element 30, and the transfer device can have at least one retaining element 48. At least one retaining element 48 and at least one locking element 30 can be implemented such that the pipette carrier 41 and the transfer device 40 are locked by means of a form interlock or pin assembly. The pipette carrier 41 can be locked in the transfer device 40 along at least one axis because the retaining element 48 of the transfer device 40 engages with the locking element 30 of the pipette carrier 41. In the illustrated example, two latches 30a of the pipette carrier 41 each engage a notch 48b of the transfer device 40 to prevent movement of the pipette carrier 41, thereby preventing movement of the pipette carrier 41 along the elongated base 44. Two additional latches 30a engage with two radial sections 48c to prevent the pipette carrier 41 from moving in the direction of the teeth 45, 46. Furthermore, two eaves 48a engage with recesses 30b to prevent the pipette carrier 41 from moving laterally to the upper side 57.

[0093] Figures 21a-22Another embodiment of the transfer device 40 of the present invention is shown. The internal teeth 46 can have a tapered cross-section that tapers towards the upper side 57 to improve force transfer from the pipetting device 42 to the transfer device 40. Therefore, the internal teeth 46 can have a larger width on the lower side 58 than on the upper side 57. The tapered cross-section of the internal teeth 46 in… Figure 21b The details are shown below. The tapered cross section can be implemented in a trapezoidal form. The cross section can be implemented such that the cross section and outer diameter of the pipette tip 2 match each other over the entire length of the internal teeth 46.

[0094] The inner teeth 46 can be configured such that at least one inner tooth 46 has a greater length than at least one other inner tooth 46. This facilitates loading the pipette carrier 41 into the transfer device 40, as the pipette carrier 41 first engages with at least one inner tooth 46 having a greater length, and in this way, it can be guided easily among the other inner teeth 46. In particular, the inner teeth 46 can gradually become longer from the outer teeth 45 to the middle 59 of the comb structure 43. Another option is that one or two inner teeth 46 at the center 59 of the comb structure 43 are shorter than the surrounding teeth 46. One or two inner teeth 46 can also be longer than the remaining inner teeth 46.

[0095] The considered length d of the internal tooth 46 can be the distance between the surface 44a on which the internal tooth 46 is arranged of the elongated base 44 and the end 46a of the internal tooth 46 opposite to the elongated base 44. In this case, the surface 44a of the elongated base 44 on which the internal tooth 46 is arranged is planar, and in particular, the attachment point of the internal tooth 46 on the elongated base 44 is located on a shared axis.

[0096] As explained, at least one stop surface 54 can be provided to guide the pipette carrier 41 when it is introduced into the transfer device 40. Furthermore, the frame 47 can have at least one peripheral guide groove 53. The guide groove 53 also facilitates the loading of the pipette carrier 41. This is particularly applicable in the case of the double-plate support 1, where the lower plate 4 moves in the guide groove 53 on the lower side 58 and the upper plate 4 moves in the guide groove 53 on the upper side 57, allowing the double-plate support 1 to be loaded into the transfer device 40 in a simple manner. Combined with the stop surface 54, at least one guide groove 53 further facilitates the loading of the pipette carrier 41.

[0097] Figure 22 A cross-section of a transfer system 55 having a transfer device 40 and a pipette carrier 41 is shown. The internal teeth 46 can have a tapered cross-section. The pipette carrier 41 is optionally filled with a pipette tip. As an example, the pipette carrier 41 is implemented as a double-plate support 1 having an upper plate 3 and a lower plate 4; however, it can also be implemented as a single-plate support. Figure 22It is clear that the tapered cross-section of the internal teeth 46 matches the outer diameter of the pipette tip along the entire height of the teeth 46, especially as the height varies. The force applied on the transfer device 40 by means of the pipetting device 42 in the direction of the upper side 57 is transferred by means of the tapered section, particularly advantageously to the upper side 57 and the collar 2c of the pipette tip 2. This particularly facilitates the sealing of the collar 2c against the sealing plate of the pipetting device 42.

[0098] Figures 23a-23c Another embodiment of the conveying device 40 of the present invention is shown. The internal teeth 46 can be reduced on the lower side 58 such that the height of the internal teeth 46 gradually decreases from the elongated base 44 to the end 46a of the internal teeth 46 away from the elongated base 44. Figure 23b A cross-section of the transfer device 40 is shown, schematically illustrating the reduction in the height of the internal teeth 46. This reduction in the height of the internal teeth 46 facilitates the application of force input from the pipetting device 42 from the lower side 58 of the transfer device 40. For example, the height of the internal teeth 46 can be reduced such that the angle of reduction in height of the internal teeth 46 is between 0.05° and 6°, particularly between 0.05° and 3°. Figure 23c The effect of the reduced height of the internal teeth 46 is schematically shown. When there is no force on the internal teeth 46, and therefore no force on the transfer device 40, the internal teeth 46 exhibit a reduced height, as described. Under force, particularly from the pipetting device 42, deformation of the internal teeth 46 occurs, causing the lower edge 58 of the internal teeth 46 to approach or reach a horizontal position. Force on the transfer device 40 in the pipetting device 42 can be applied in the direction of the upper edge 57, causing the transfer device to press against the area of ​​the pipetting device 42, particularly the sealing plate. The internal teeth 46 can be used for force transfer from the pipetting device 42 to the pipette carrier 41. The pipette carrier can be a disposable product with larger manufacturing tolerances than the transfer device 40. Therefore, the reduced height of the internal teeth 46 ensures compensation for the manufacturing tolerances of the pipette carrier 41 and means that the sealing plate 70 of the pipetting device 42 will not be damaged by the pipette carrier 41 when force is applied to the transfer device 40.

[0099] Figure 24 Another embodiment of the conveying device 40 of the present invention is shown. The conveying device 40 may have gripping elements 61 on the frame 47, such as, for example, flanges, edges, or surfaces, by means of which forces can be applied to the conveying device 40. In the illustrated example, the gripping element 61 is implemented as a surface.

[0100] Figures 25-27 An embodiment of the transfer system 55 of the present invention, having a transfer device 40 and a single-plate support 20, is shown. The transfer system 55 optionally includes a plurality of pipette tips 2 placed in an opening 22. Figure 26An exploded view of the conveyor system 55 is shown, in which the conveyor device 40 and the board support 20 are oriented to hold the board support 20 via the conveyor device 40. Figure 27 and Figure 25 In this process, the support device 33 is fully loaded into the conveying device 40. The single-plate support 20 can be loaded into the conveying device 40 such that the internal teeth 46 are arranged between the directional elements 23. Figure 25 A view of the transfer system 55 at the end 46a of the teeth is shown. The inner teeth 46 are able to protrude beyond the pipette tip 2. In particular, when the inner teeth 46 are configured such that at least one inner tooth 46 is longer than at least one other inner tooth 46, at least one other inner tooth 46 is also able to end before the final position of the pipette tip 2.

[0101] Figures 28-29 Another embodiment of the conveying system 55 of the present invention, having a conveying device 40 and a veneer support 20, is shown. At least one gripping part 27 can be arranged to be introduced into a frame recess 49. The veneer support 20 can be released from the conveying device 40 by applying force to at least one gripping part 27 or to both gripping parts 27.

[0102] Figures 30-31 An embodiment of the transfer system 55 of the present invention, having a transfer device 40 and a double-plate support, is shown. Optionally, the transfer system 55 has a plurality of pipette tips 2 which are introduced into a first channel 5 and a second channel 6. Figure 30 This illustrates how the support system 17 is introduced into the transmission device 40, while Figure 31 In this configuration, the support system 17 is entirely within the transfer device 40. In this case, the double-plate support 1 can be introduced into the transfer device such that the inner teeth 46 are arranged between the upper plate 3 and the lower plate 4. The inner teeth 46 can protrude beyond the pipette tip 2. Specifically, when the inner teeth 46 are configured such that at least one inner tooth 46 is longer than at least one other inner tooth 46, at least one other inner tooth 46 can also end before the final position of the pipette tip 2 (compare). Figure 25 ).

[0103] Figures 32-33Two embodiments of the pipetting system 80 of the present invention are shown. The pipetting system 80 includes a pipetting device 42 and a delivery system 55, the delivery system 55 further including a delivery device 40, a pipette support 41, and a plurality of pipette tips 2. The pipetting device 42 may have a pipette tip 72 and a sealing plate 70, in which a pipetting channel 71 is arranged for allowing liquid to enter and exit the pipette tip 2, and in the sealing plate 70, the pipetting channel is guided through the sealing plate 70. The sealing plate 70 is used to seal the pipette tip. The pipetting device 42 is adaptable to apply force to the delivery device 40 such that the pipette tip 2 is sealed against the sealing plate 70 with its collar 2c arranged in the pipette carrier 41. Figure 32 The diagram shows the transfer system 55 being horizontally introduced into the pipetting device 42, while... Figure 33 It is introduced vertically. To support the vertical introduction of the transfer system 55, at least two, and in particular four, orienting elements 52 can be arranged on the pipette carrier 41. For details regarding the pipetting device, particularly the construction of the pipetting head, and especially the arrangement and embodiment of the pipetting channel and sealing plate, please refer to utility model patent DE202008013533 U1.

[0104] The following describes how the pipette carrier 41 is introduced into the transfer device 40 and how the transfer system 55 thus formed is introduced into the pipetting apparatus 42. Then, it will be described how, firstly, the transfer system 55 can be removed from the pipetting apparatus 42, and finally, how the pipette carrier 41 can be removed from the transfer system 55.

[0105] Based on Figure 20 A method for introducing a pipette carrier 41 (particularly a double-plate support 1 or a single-plate support 20) into a transfer device 40 is described. In this case, firstly, the pipette carrier 41 is introduced into the transfer device 40. The pipette carrier 41 includes at least one locking element 30, and the transfer device 40 includes at least one retaining element 48, wherein the at least one locking element 30 is implemented corresponding to the at least one retaining element 48. In this case, a section of the pipette carrier 41 can be positioned on internal teeth 46. Specifically, the internal teeth 46 enter between the upper plate 3 and the lower plate 4 of the double-plate support 1 or between the directional elements 23 of the single-plate support 20. In this case, the upper plate 3 or plate 21 can be positioned on the internal teeth 46 and, in a given case, can be guided by means of at least one stop surface 54 and / or at least one guide groove 53. The pipette carrier 41 is then locked in the transfer device 40 because a first force is applied to the pipette carrier 41 in the direction of the elongated base 44 until at least one retaining element 48 engages with at least one locking element 30.

[0106] The transfer system 55 configured in this way can then be introduced into the pipetting device 42 manually or automatically. In the case of horizontal introduction into the pipetting device 42, such as in... Figure 32 As illustrated by way of example, the transfer system 55 can be introduced by means of the handle 50 of the transfer device 40. Additionally, for automatic introduction, a centering element 51 in the handle 50 can be used. In the case of vertical introduction into the pipette 42, such as in... Figure 33 As illustrated by way of example, the pipette head 72 is movable in the z-axis direction in order to hold the delivery system 55 with the help of the orientation element 52.

[0107] In order to perform the pipetting process, the pipette tip 2 must be sealed against the sealing plate 70. For this purpose, a pulling force can be applied by means of the pipetting device 42, in each case, applied to the two long sides of the transfer system 55, causing the transfer system 55 to press against the sealing plate 70. If the pipette carrier 41 is a double-plate support 1, the pulling force can be applied to the gripping element 61 of the transfer device 40 and the force input element 14 of the double-plate support 1. Therefore, the pipetting device 42 can have a corresponding bearing element that is pressed against the gripping element 61 and the force input element 14. If the pipette carrier 1 is a single-plate support 20, the pulling force can be applied to the gripping element 61 of the transfer device 40 and the engaging element 60 of the transfer device 40. Furthermore, in this case, the pipetting device 42 can have a corresponding bearing element that is pressed against the gripping element 61 and the engaging element 60. The bearing element can be arranged on a pivotable arm.

[0108] After the transfer system 55 in the pipetting apparatus 42 is sealed, the pipetting process can be performed. After the pipetting process is terminated, the tension can be released, and the transfer system 55 can be discarded by means of the pipette tip 72 or released from the pipetting apparatus 42 by means of the handle 50.

[0109] In a further step, the pipette carrier 41 can be removed from the transfer system 55. For this, the lock between at least one locking element 30 and at least one retaining element 48 must be released. This can occur because a second force is applied to the pipette carrier 41 in the direction of the lower edge 58 of the comb structure 43, causing the lock between at least one retaining element 48 and at least one locking element 30 to be released. The second force can be applied manually or automatically. In the case of the single-plate support 20, the second force can be applied to at least one gripping portion 27 of the single-plate support 20. Preferably, the single-plate support 20 has two gripping portions 27, and the second force is applied to both gripping portions 27 simultaneously. In the case of the double-plate support 1, the second force can be applied to at least one gripping element 13. In both cases, the transfer device 40 can have a frame recess 49 with the gripping portion 27 or gripping element 13 protruding inward, allowing the operator or robot to easily access and manipulate the gripping portion 27 or gripping element 13.

[0110] List of reference numerals

[0111] 1. Double-plate support

[0112] 1a Lateral axis of the double-plate support

[0113] 2. Pipette tip

[0114] 2a Remote region

[0115] 2b Proximal region

[0116] 2c collar

[0117] 3 on board

[0118] 3a The first long side of the upper plate

[0119] 3b Middle of the upper plate

[0120] The second longest side of the 3C top plate

[0121] 4. Lower plate

[0122] 4a The first long side of the lower plate

[0123] 5 First Channel

[0124] 6 Second Channel

[0125] 7. Sidewalls

[0126] 8 support rods

[0127] 9. Boundary

[0128] 10 Radial segments

[0129] 11 Spacers

[0130] 12. Material Reduction Department

[0131] 13 Gripping Components

[0132] 14 Force input element

[0133] 15 Code Area

[0134] 16 Code Elements

[0135] 17 Support System

[0136] 20 Single-plate support components

[0137] 20a Lateral axis

[0138] 21 boards

[0139] The long side of plate 21a

[0140] Horizontal edge of plate 21b

[0141] 22 Opening

[0142] 23 Orientation Components

[0143] 24 Radial segments

[0144] 26 Load-bearing elements

[0145] 27. Grasp Department

[0146] 28 Identification Area

[0147] 29 Identification Components

[0148] 30 Locking element

[0149] 30a buckle

[0150] 30b notch

[0151] The top of board 31

[0152] The bottom of plate 32

[0153] 33 Support device

[0154] 34 Reinforcing Components

[0155] 35 spacers

[0156] 36 Material Reducer

[0157] 40 Conveying equipment

[0158] 41 Pipette Carrier

[0159] 42. Pipettes

[0160] 43. Comb-like structure

[0161] 44 Slender base

[0162] 44a surface

[0163] 45 External teeth

[0164] 46 internal teeth

[0165] 46a End of internal tooth

[0166] 47 Framework

[0167] 48 Holding element

[0168] 48a Eaves

[0169] 48b notch

[0170] 48c radial segment

[0171] 49. Frame dent

[0172] 50 Handle

[0173] 51 Centering element

[0174] 52 Orientation Components

[0175] 53 Guide slot

[0176] 54 Stopping surface

[0177] 55. Conveyor System

[0178] 57 Above

[0179] 58 Below

[0180] 59. Middle part of the comb-like structure

[0181] 60 Connecting elements

[0182] 61 Gripping Components

[0183] 70 Sealing Plate

[0184] 71 Pipetting Channel

[0185] 72 pipette tips

[0186] 80 Pipetting System

Claims

1. A transfer device (40) for introducing a pipette carrier (41) into a pipetting apparatus (42), comprising: - A comb-like structure (43) having an elongated base (44) and a plurality of teeth (45, 46) arranged perpendicular thereto, wherein the teeth are arranged parallel to each other and equidistantly and include two outer teeth (45) and a plurality of inner teeth (46) arranged between the outer teeth (45), wherein the elongated base (44) and the two outer teeth (45) are implemented in the form of a three-sided frame (47), wherein the comb-like structure (43) has an upper side (57) and a lower side (58). - Wherein, the height of the internal tooth (46) on the lower side (58) is reduced such that the height of the internal tooth (46) gradually decreases from the elongated base (44) to the end (46a) of the internal tooth (46) away from the elongated base (44).

2. The conveying device (40) according to claim 1. in, The height of the inner tooth (46) on the lower side is reduced such that when a force is applied to the inner tooth (46), the inner tooth (46) deforms at most until the lower side of the inner tooth (46) approaches or reaches a horizontal position.

3. The transmission device (40) according to any one of the preceding claims. in, The height of the internal tooth (46) is reduced such that the height of the internal tooth (46) is reduced at an angle between 0.05° and 3°.

4. The transmission device (40) according to any one of the preceding claims. in, The transfer device (40) includes at least one retaining element (48) arranged on the frame (47) and configured such that the pipette carrier (41) can be locked in the transfer device (40) along at least one axis.

5. The transmission device (40) according to any one of the preceding claims. in, The conveying device (40) includes a handle (50) arranged on the elongated base (44).

6. The transmission device (40) according to any one of the preceding claims. in, The frame (47) includes a frame recess (49) in the region of the elongated base (44) and particularly centrally located on the elongated base (44).

7. The transmission device (40) according to any one of the preceding claims. in, The frame (47) includes at least one peripheral guide groove (53).

8. The transmission device (40) according to any one of the preceding claims. in, The frame (47) includes at least one stop surface (54) arranged at least along the elongated base (44) and at the same height as the upper edge of the inner teeth (46) or between the teeth (45, 46).

9. The transmission device (40) according to any one of the preceding claims. in, The internal teeth (46) have at least one engagement element (60) at one of the ends (46a) away from the elongated base (44), by means of which force can be applied to the conveying device (40).

10. The transmission device (40) according to any one of the preceding claims. in, The frame (47) includes gripping elements (61), such as shoulders, edges or surfaces, by means of which force can be applied to the conveying device (40).

11. The transmission device (40) according to any one of the preceding claims. in, The internal tooth (46) has a tapered cross section that tapers in the direction of the upper side (57).

12. The transmission device (40) according to any one of the preceding claims. in, At least one internal tooth (46) has a longer length than at least one other internal tooth (46).

13. The transmission device (40) according to any one of the preceding claims. in, The inner teeth (46) gradually lengthen from the outer teeth (45) to the middle (59) of the comb-like structure (43).

14. A transmission system (55), comprising: - Pipette carrier (41), particularly a double-plate support (1) or a single-plate support (20), and - The transmission device (40) according to any one of the preceding claims. The pipette carrier (41) can be introduced into the transfer device (55).

15. A pipetting system (80), comprising: - The transmission system (55) according to any one of the preceding claims. - A pipetting device (42) having a pipetting tip (72) having a sealing plate (70) and a plurality of pipetting channels (71) for drawing liquid into and discharging liquid from the pipetting tip (2), wherein the pipetting channels (71) are guided through the sealing plate (70). The transfer system (55) can be introduced into the pipetting device (72), and the pipetting device (72) is adapted to apply force to the transfer device (55) such that the pipetting tip (2) arranged in the pipetting carrier (41) is sealed against the sealing plate (70).

Images