A gastrointestinal micro-ecological sampling device

Abstract

The application discloses a digestive tract micro-ecological sampling device, and belongs to the field of medical instruments, and solves the problems of random positioning, easy pollution, difficult operation and high cost of existing devices. The device comprises a magnetic induction device (an electromagnetic inductor, a magnetic field detection chip and the like, which realize accurate positioning and multi-mode alarm), an external magnetic control device (which can adjust an external magnet to adapt to different digestive tract parts), and a magnetic control capsule (a spring and a magnet cooperate to realize closed-sampling-reset switching, and the capsule comprises a filtering and adsorbing structure). The device can target sterile sampling, is simple and easy to operate, has controllable cost and safety, and is suitable for health management and disease diagnosis.

Description

A digestive tract microecological sampling device Technical Field

[0001] This invention relates to the field of medical device technology, specifically to a digestive tract microecological sampling device. Background Technology

[0002] The digestive tract microecological environment is an important component of the human body's internal environment. Its microbial composition and biological and physicochemical properties are closely related to the occurrence and development of various diseases, including tumors, immune diseases, and neuropsychiatric and behavioral disorders, directly affecting human health. Therefore, the detection of the microbial composition and related properties of fluids in the digestive tract has become a research hotspot in the fields of health management and disease diagnosis and treatment.

[0003] Currently, the conventional method for sampling the digestive tract microecology involves collecting gastric and intestinal fluids or processing the gastrointestinal mucosa before testing. However, due to the physiological characteristics of the digestive tract—thin walls, long and winding course, and significant differences in the microecological environment of different parts—and the susceptibility of sampling to contamination from testing and transport equipment, sampling must meet three core requirements: aseptic technique, accuracy, and safety. However, existing sampling equipment generally suffers from the following shortcomings:

[0004] Its structure is complex, its operation is difficult, it requires professional personnel to operate, and it is difficult to promote in primary healthcare institutions;

[0005] High manufacturing costs and expensive single sampling costs make it unsuitable for large-scale clinical applications.

[0006] The sampling process is susceptible to external contamination, which can lead to deviations in test results.

[0007] The sampling points are random and cannot be accurately located to the target digestive tract area, making it difficult to reflect the microecological status of a specific area.

[0008] To address the aforementioned issues, this invention provides a magnetically controlled and magnetically anchored digestive tract microecological sampling device. Through magnetic positioning and a closed sampling design, it achieves accurate positioning, precise sampling, and safe and pollution-free sampling, while also being low in cost and easy to operate. Summary of the Invention

[0009] To address the shortcomings of existing digestive tract microecological sampling devices, the purpose of this invention is to provide a magnetically controlled and magnetically anchored digestive tract microecological sampling device that achieves sampling effects of "precise positioning, sterile sampling, simple operation, and controllable cost," making it suitable for primary healthcare institutions and large-scale clinical applications.

[0010] To achieve the above objectives, the present invention employs the following technical means:

[0011] A digestive tract microecological sampling device includes a magnetic induction device, an external magnetic control device, and a magnetic control capsule. The magnetic induction device is magnetically connected to the magnetic control capsule, and the external magnetic control device is magnetically anchored to the magnetic control capsule.

[0012] The magnetic induction device includes a magnetic induction housing. A buzzer alarm, an OLED display screen, a control switch, a light alarm, and multiple sets of electromagnetic sensors are connected externally to the magnetic induction housing. A power supply, a vibration alarm module, a magnetic field strength detection chip, and an MCU microcontroller unit are connected internally to the magnetic induction housing. The OLED display screen, control switch, power supply, magnetic field strength detection chip, and MCU microcontroller unit are connected in series to form a control loop. The buzzer alarm, OLED display screen, light alarm, vibration alarm module, magnetic field strength detection chip, and electromagnetic sensors are each electrically connected to the MCU microcontroller unit.

[0013] The external magnetic control device includes an external magnetic control housing, which is connected to multiple sets of circumferentially distributed guide rails. The top of the guide rails is provided with a sliding groove, and a sliding rod is slidably connected in the sliding groove. The top of the sliding rod is connected to an external magnet disposed on the top of the guide rail. The side of the guide rail is provided with a positioning groove communicating with the sliding groove. The sliding rod is positioned and connected to the guide rail by a fixing wire passing through the positioning groove.

[0014] The magnetically controlled capsule includes an upper capsule shell and a lower capsule shell detachably connected to the upper capsule shell. The upper capsule shell has an opening at the end away from the lower capsule shell for draining gastrointestinal fluid. A compartment partition is connected inside the lower capsule shell, and an inner shaft is inserted into the compartment partition. One end of the inner shaft is connected to the inner end of the lower capsule shell.

[0015] An inner magnet is provided on the side of the compartment partition away from the upper capsule shell, and the inner magnet is sleeved on the outside of the inner shaft; a compression spring is provided on the side of the inner magnet away from the compartment partition, and the compression spring is sleeved on the outside of the inner shaft, with one end of it connected to the inner end of the lower capsule shell.

[0016] The upper capsule shell is provided with an outer shaft, which is sleeved on the outside of the inner shaft and passes through the compartment partition. One end of the outer shaft is connected to the inner magnet, and the other end is connected to a piston for sealing the opening.

[0017] In the resting state, the pressure of the compression spring pushes the inner magnet to move upward toward the capsule shell, causing the outer shaft and piston to seal the opening; in the active state, the inner magnet is attracted and fixed to the target intestinal wall by the outer magnet, pulling the outer shaft and piston downward toward the capsule shell, causing the piston to disengage from the opening.

[0018] Preferably, a wristband connector is connected to the bottom of the magnetic induction housing, and a wristband is detachably connected to the wristband, the two ends of which are connected by Velcro. This is used to fix the device to the user's wrist.

[0019] Preferably, the light alarm is a three-color LED light, which uses red, yellow and green to respectively indicate "not located", "approaching target" and "located successfully".

[0020] Preferably, the external magnetic control housing is a protective shell that can block magnetic fields. The top of the external magnetic control housing is detachably connected to a control shell cover, and the bottom of the external magnetic control housing is connected to an arc-shaped grip structure. The surface of the arc-shaped grip structure is covered with anti-slip textures.

[0021] Preferably, the inner wall of the upper capsule shell is provided with multiple sets of guide grooves.

[0022] Preferably, the upper capsule shell is connected to an adsorption structure for adsorbing gastrointestinal fluid around the magnetically controlled capsule, and a filter membrane is connected to the outside of the adsorption structure. The adsorption structure is a sterile or sterilized adsorption material.

[0023] Preferably, the piston is an elastic seal and the compression spring is a mechanical reset element.

[0024] Preferably, the lower capsule shell is detachably connected to the upper capsule shell via a connecting sleeve.

[0025] Preferably, an information storage unit is connected inside the lower capsule shell.

[0026] The present invention has the following beneficial effects:

[0027] 1. Precise positioning: Solves the problem of random sampling.

[0028] Precise site identification: By comparing the signals of the electromagnetic sensors arranged in zones with those of the MCU microcontroller unit, the specific digestive tract location of the magnetically controlled capsule can be clearly identified, achieving targeted sampling and avoiding the problem of random sampling points in traditional equipment.

[0029] Precise and accurate control: By using a magnetic field strength detection chip to monitor the distance between the capsule and the body surface, an alarm is triggered only when the capsule reaches the target depth, effectively avoiding mispositioning caused by the capsule being close to the body surface but not reaching the target area.

[0030] Clear status feedback: Combining three-color light, buzzer, and vibration alarm modes with data presentation on an OLED display, it intuitively conveys positioning progress and results without relying on operational experience.

[0031] 2. Sterile and reliable: Eliminates the risk of sample contamination.

[0032] Dynamic sealing protection: The magnetically controlled capsule achieves switching between "resting sealing - active sampling - resetting sealing" through the coordinated action of spring and magnetism. In the non-sampling state, the piston seals the opening to prevent non-target liquids from entering; after sampling, it immediately resets to prevent the sample from coming into contact with external contamination.

[0033] Multi-stage sample purification: The filter membrane inside the capsule can filter out impurities in gastrointestinal fluid, and the adsorption structure selectively adsorbs only the target liquid, ensuring the purity of the sample used for subsequent testing.

[0034] Completely pollution-free pathway: The capsule is completely sealed from swallowing to excretion, and no additional transfer container is needed after sampling, avoiding secondary contamination during transportation.

[0035] 3. Easy to operate: Lowers the barrier to entry for users.

[0036] Lightweight and easy to operate: The wristband-style magnetic induction device can be worn on the wrist, freeing up your hands; the curved handle and anti-slip design of the external magnetic control device fit the hand well, making it less tiring to operate for a long time, and can be completed without professional personnel.

[0037] Visualized process monitoring: The capsule shell and outer shaft are made of transparent material, allowing for direct observation of sample adsorption; the display screen simultaneously presents key data, making the operation process controllable.

[0038] Multi-scenario adaptation: The triple alarm mode is adapted to noisy environments and hearing-impaired operators, ensuring accurate acquisition of positioning signals in different scenarios.

[0039] 4. Controllable cost: Adaptable to large-scale applications

[0040] Low manufacturing cost: The core components are made of conventional medical materials and do not require special precision machining, which greatly reduces the overall manufacturing cost of the device.

[0041] Economical per sampling: The capsules are modularly designed, allowing for mass production and eliminating the need for repeated sterilization consumables, thus controlling the cost per sampling.

[0042] Low maintenance cost: The device has a simple structure, no complex electronic adjustment components, low failure rate, and no need for professional technical support for later maintenance.

[0043] 5. High adaptability: Covers the needs of the entire digestive tract.

[0044] Flexible application scenarios: The spacing between the external magnets of the external magnetic control device is adjustable, which can adapt to the magnetic control needs of different widths of the digestive tract.

[0045] Intelligent sample management: The information storage unit inside the capsule can record relevant sample information, facilitating full-process traceability management of samples and avoiding confusion.

[0046] Wide compatibility: The extracted samples can be adapted to various microecological detection technologies to meet the needs of different detection scenarios.

[0047] 6. Security Guarantee: Enhanced safety during use

[0048] Non-invasive sampling experience: The capsules can be swallowed naturally without intubation or anesthesia, avoiding the risk of damage to the digestive tract mucosa caused by traditional sampling methods.

[0049] Biosafe and reliable: All parts that come into contact with body fluids meet biocompatibility requirements, are non-allergenic and non-cytotoxic, and can be safely excreted from the body.

[0050] Operational safety redundancy: The compression spring force is precisely calibrated to ensure reliable piston reset, and the magnetic force is adjusted within a safe threshold to prevent excessive traction from damaging the digestive tract. Attached Figure Description

[0051] Figure 1 is a schematic diagram of the structure of the present invention;

[0052] Figure 2 is a schematic diagram of the magnetic induction device of the present invention;

[0053] Figure 3 is a schematic diagram of the structure of the magnetic induction housing of the present invention;

[0054] Figure 4 is a schematic diagram of the external magnetic control device of the present invention;

[0055] Figure 5 is a schematic diagram of the structure of the outer magnetic housing of the present invention;

[0056] Figure 6 is a schematic diagram of the structure of the guide rail of the present invention;

[0057] Figure 7 is an exploded structural diagram of the magnetically controlled capsule of the present invention;

[0058] In the attached figures, the following labels are used:

[0059] Magnetic induction device 100, magnetic induction housing 101, buzzer alarm 102, OLED display screen 103, control switch 104, light alarm 105, power supply 106, vibration alarm module 107, magnetic field strength detection chip 108, MCU microcontroller unit 109, electromagnetic sensor 110, wristband connector 111, wristband 112, Velcro 113;

[0060] External magnetic control device 200, external magnetic control housing 201, guide rail 202, slide groove 203, external magnet 204, slide rod 205, positioning groove 206, fixing screw 207, control housing cover 208, arc-shaped grip handle structure 209, anti-slip texture 210;

[0061] Magnetic control capsule 300, upper capsule shell 301, flow guide groove 302, opening 303, piston 304, outer shaft 305, filter membrane 306, adsorption structure 307, compartment partition 308, inner magnet 309, compression spring 310, inner shaft 311, connecting sleeve 312, lower capsule shell 313, information storage unit 314. Detailed Implementation

[0062] The technical solution of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0063] As shown in Figures 1-7, a digestive tract microecological sampling device includes a magnetic induction device 100, an external magnetic control device 200, and a magnetically controlled capsule 300. The magnetic induction device 100 is magnetically connected to the magnetically controlled capsule 300, and the external magnetic control device 200 is magnetically anchored to the magnetically controlled capsule 300.

[0064] Magnetic induction device 100

[0065] The magnetic induction device 100 is used to locate the position of the magnetically controlled capsule 300 in real time and to provide feedback on the positioning status through a multi-module alarm. Its structure includes:

[0066] Magnetic induction housing 101: This is the main frame of the device. Externally, it integrates a buzzer alarm 102, an OLED display screen 103, a control switch 104, a light alarm 105, and multiple electromagnetic sensors 110. Internally, it integrates a power supply 106, a vibration alarm module 107, a magnetic field strength detection chip 108, and an MCU microcontroller unit 109.

[0067] Positioning and alarm mechanism: Multiple sets of electromagnetic sensors 110 are arranged in zones along the surface of the digestive tract, each group corresponding to a specific part of the digestive tract; the MCU microcontroller unit 109 identifies the specific position of the magnetically controlled capsule 300 by comparing the magnetic field signal strength of each set of electromagnetic sensors 110; the magnetic field strength detection chip 108 monitors the distance between the capsule and the body surface in real time. When the distance reaches a preset threshold, the MCU triggers a buzzer alarm 102, a three-color LED light alarm 105 (red - not located, yellow - approaching, green - successful) and a vibration alarm module 107, which is suitable for noisy environments or hearing-impaired operators;

[0068] Data shows that the OLED display 103 displays the current location of the digestive tract, the distance to the capsule, and the alarm status in real time, avoiding reliance on experience for operation.

[0069] Fixed structure: The bottom of the magnetic induction housing 101 is connected to the wristband 112 via the wristband connector 111. The two ends of the wristband are fixed with Velcro 113, so that the device can be worn on the user's wrist, freeing up the hands.

[0070] External magnetic control device 200

[0071] The external magnetic control device 200 is used to control the sampling state of the magnetically controlled capsule 300 through magnetic force, and can be adapted to the magnetic control requirements of different parts of the digestive tract. Its structure includes:

[0072] External magnetic control shell 201: It adopts a protective shell that can block magnetic fields and effectively block external magnetic fields; the top can be detachably connected to the control shell cover 208 for easy maintenance; the bottom integrates an arc-shaped grip structure 209, and the surface is covered with medical-grade silicone anti-slip texture 210, which conforms to the curvature of the palm and reduces hand fatigue during long-term operation.

[0073] Adjustable external magnet assembly: The housing is provided with multiple sets of circumferentially distributed guide rails 202. The external magnets 204 are connected in the top groove 203 of the guide rails via slide rods 205. The slide rods 205 can move along the groove 203 to adjust the spacing of the external magnets 204. The position is then fixed by the fixing wires 207 that pass through the positioning groove 206. The spacing is reduced in narrow parts to enhance local magnetic force, and the spacing is increased in open parts to achieve large-range magnetic control, thus improving the adaptability of the device.

[0074] Magnetically controlled capsule 300

[0075] The magnetically controlled capsule 300 is a sampling execution unit that achieves aseptic sampling through switching between "resting closure - active sampling - resetting closure". Its structure includes:

[0076] Shell and connection: It consists of an upper capsule shell 301 and a lower capsule shell 313, which are detachably connected by a connecting sleeve 312; the inner wall of the upper capsule shell 301 is provided with a guide groove 302 to guide the gastrointestinal fluid to flow quickly to the sampling structure, and the end is provided with an opening 303 for drainage;

[0077] Sampling and Sealing Structure: The upper capsule shell 301 is equipped with an adsorption structure 307 (sterile or sterilized adsorption material with strong adsorption capacity), and is wrapped with a filter membrane 306 on the outside to filter impurities in gastrointestinal fluid; the lower capsule shell 313 is connected to an inner shaft 311 through a compartment partition 308, and an inner magnet 309 and a compression spring 310 (mechanical reset component) are sleeved on the outside of the inner shaft; the outer shaft 305 inside the upper capsule shell 301 passes through the compartment partition 308, with one end connected to the inner magnet 309 and the other end connected to a rubber piston 304 (elastic seal with good sealing performance).

[0078] State switching principle:

[0079] In the resting state: the compression spring 310 extends naturally, pushing the inner magnet 309 to move upward, which in turn drives the piston 304 through the outer shaft 305 to block the opening 303, sealing the capsule and preventing liquid from entering non-target areas to prevent contamination;

[0080] Activity state (sampling): Hold the external magnetic control device 200 and align the external magnet 204 with the target position. The magnetic force of the external magnet attracts the internal magnet 309 to move downward against the spring force, which drives the piston 304 to disengage from the opening 303. The gastrointestinal fluid is absorbed by the adsorption structure 307 through the guide groove 302 and the filter membrane 306.

[0081] Reset state: After sampling is completed, the magnetic force of the external magnetic control device 200 is removed, the compression spring 310 resumes its extension, pushes the piston 304 to re-seal the opening 303, the capsule returns to its sealed state, and is expelled from the body with the peristalsis of the digestive tract.

[0082] Sample management: The lower capsule shell 313 integrates an information storage unit 314, which facilitates the traceability and management of samples.

[0083] Working principle

[0084] This device achieves a closed-loop process of "positioning-sampling-resetting-processing" through the coordinated action of the magnetic induction device 100 for positioning, the external magnetic control device 200 for sample control, and the magnetically controlled capsule 300 for sampling. The core principles of each stage are as follows:

[0085] I. Preparation Phase: Initial State Setting

[0086] Initial state of Magnetically Controlled Capsule 300:

[0087] In the resting state, the compression spring 310 is in a naturally extended state, and its elastic force pushes the inner magnet 309 to move upward towards the capsule shell 301; the inner magnet 309 drives the outer shaft 305, which is sleeved on the outside of the inner shaft 311, to move synchronously, so that the piston 304 at the end of the outer shaft 305 tightly seals the opening 303 of the capsule shell 301, ensuring that the capsule is in a sealed state before entering the target area, and preventing non-target liquids from entering.

[0088] Deployment of magnetic induction device 100:

[0089] The wristband 112 is installed through the wristband connector 111 at the bottom of the magnetic induction housing 101, and the device is worn on the user's wrist and secured by the nylon buckle 113; when the control switch 104 is turned on, the power supply 106 supplies power to the MCU microcontroller unit 109, the magnetic field strength detection chip 108, the electromagnetic sensor 110 and other components, and the device enters standby mode.

[0090] II. Positioning Phase: Precisely Locating the Target Location

[0091] The core of this stage is that the magnetic induction device 100 monitors the magnetic field signal to determine whether the magnetically controlled capsule 300 has reached the target digestive tract location. The specific process is as follows:

[0092] Magnetic field signal acquisition:

[0093] After the user swallows the magnetically controlled capsule 300, the capsule moves with the peristalsis of the digestive tract; the inner magnet 309 inside the capsule generates a continuous magnetic field, and multiple sets of electromagnetic sensors 110 on the outside of the magnetic induction device 100 (arranged in zones along the projection area of ​​the digestive tract surface, such as different groups corresponding to the esophagus, gastric fundus, and ileum) collect the magnetic field signal in real time and transmit the signal to the MCU microcontroller unit 109.

[0094] Location and depth determination:

[0095] Location identification: The MCU microcontroller unit 109 compares the magnetic field signal strength received by different groups of electromagnetic sensors 110, and the area corresponding to the sensor with the strongest signal is the digestive tract location where the capsule is currently located.

[0096] Depth determination: The magnetic field strength detection chip 108 calculates the distance between the inner magnet 309 and the magnetic induction device 100 in real time. When the distance reaches the preset threshold (i.e., the depth at which the capsule reaches the target part), a trigger signal is transmitted to the MCU microcontroller unit 109.

[0097] Location status feedback:

[0098] MCU microcontroller unit 109 synchronously activates multiple module alarms:

[0099] The light alarm 105 displays green (red when not in position, yellow when approaching the target);

[0100] The buzzer alarm 102 emits a warning sound, and the vibration alarm module 107 is activated (suitable for noisy environments or people with hearing impairments).

[0101] The OLED display 103 displays "Location successful", "Current location: XX" and "Distance: X.Xcm" in real time, informing the operator that the positioning is complete.

[0102] III. Sampling Stage: Aseptic Sampling Under Magnetic Control

[0103] During this stage, the magnetically controlled capsule 300 is switched to an active state by the magnetic force of the external magnetic control device 200 to complete the collection of gastrointestinal fluid. The specific principle is as follows:

[0104] External magnetic control device 200 adjustment and deployment:

[0105] According to the width of the target digestive tract region (such as duodenal stenosis or open stomach), the operator pushes the slide bar 205 along the guide rail 202 inside the external magnetic control housing 201 to move it within the slide groove 203, adjusting the spacing of the external magnets 204 (reducing the spacing in narrow areas to enhance local magnetic force, and increasing the spacing coverage in open areas); after adjustment, the slide bar 205 is fixed by a fixing wire 206 passing through the positioning groove 207 to ensure the stable position of the external magnets 204; the operator holds the arc-shaped grip structure 209 (with anti-slip texture 210 on the surface to prevent slippage) and aligns the external magnets 204 with the successfully positioned area on the body surface.

[0106] Sampling action of the magnetically controlled capsule 300:

[0107] The inner magnet 309 moves under force: the magnetic force generated by the outer magnet 204 attracts the inner magnet 309 inside the magnetically controlled capsule 300, causing it to overcome the elastic force of the compression spring 310 and move towards the downward capsule shell 313.

[0108] Opening 303: The inner magnet 309 drives the outer shaft 305 to move synchronously, causing the piston 304 to disengage from the opening 303 of the upper capsule shell 301, and the sampling channel is opened.

[0109] Gastrointestinal fluid collection and purification: The gastrointestinal fluid in the digestive tract flows rapidly into the interior along the guide groove 302 on the inner wall of the upper capsule shell 301. It first passes through the filter membrane 306 to remove food residues and other impurities, and then is adsorbed and stored by the adsorption structure 307, thus completing aseptic sampling.

[0110] IV. Reset Phase: Samples are stored in sealed containers.

[0111] After sampling is completed (usually adsorption for 1-2 minutes), the operator removes the external magnetic control device 200 and cancels the magnetic force on the internal magnet 309.

[0112] Compression spring 310 resets: Compression spring 310 returns to its natural extended state, pushing inner magnet 309 to move upward towards capsule shell 301;

[0113] Opening 303 is resealed: the inner magnet 309 drives the outer shaft 305 and piston 304 to reset, and the piston 304 seals the opening 303 again to ensure that the sample is isolated from the outside world and avoids contamination;

[0114] Capsule expulsion: The magnetically controlled capsule 300 moves naturally with the peristalsis of the digestive tract and is eventually expelled from the body with feces. The information storage unit 314 inside the lower capsule shell 313 can record capsule information for easy identification and collection later.

[0115] V. Sample Processing Stage: Extracting Target Samples

[0116] Capsule collection and disinfection: Collect the discharged magnetically controlled capsules 300, and wipe the outer shells of the upper capsule shell 301 and lower capsule shell 313 with 75% ethanol to complete surface disinfection;

[0117] Capsule disassembly: Unscrew the connecting sleeve 312 that connects the upper capsule shell 301 and the lower capsule shell 313 to separate the two shells;

[0118] Sample extraction: Use sterile forceps to remove the adsorption structure 307 inside the upper capsule shell 301, transfer it into an EP tube containing sterile physiological saline, shake and elute, and obtain a pure gastrointestinal fluid sample after centrifugation, which can be used for subsequent microecological detection (such as 16S rRNA sequencing).

[0119] Summary of core collaborative relationships

[0120] Synergy of forces: The elastic force of the compression spring 310 (maintaining a tight seal) and the magnetic force of the external magnet 204 (controlling opening) form a dynamic balance, achieving precise switching of the sampling state;

[0121] Signal coordination: The location signal from the electromagnetic sensor 110 and the depth signal from the magnetic field strength detection chip 108 are integrated through the MCU microcontroller unit 109 to achieve dual assurance of positioning accuracy;

[0122] The devices work together: the magnetic induction device 100 is responsible for "finding the location", the external magnetic control device 200 is responsible for "controlling the switch", and the magnetic control capsule 300 is responsible for "storing the sample". The three work together to achieve sterile and accurate sampling throughout the process.

[0123] Example 1

[0124] Sampling of the gastric antrum microecology (applicable to Helicobacter pylori-related testing)

[0125] I. Application Scenarios

[0126] For patients suspected of Helicobacter pylori infection, it is necessary to accurately collect gastrointestinal fluid from the antrum of the stomach to analyze the composition of the flora and metabolites in this area, which can help diagnose gastric mucosal inflammation or ulcer-related microecological imbalance.

[0127] II. Adjustment of Device Parameters

[0128] Magnetic induction device 100: The sensor group corresponding to the "gastric antrum" among the 6 groups of electromagnetic sensors is set as the target monitoring group. The magnetic field strength detection chip has a preset distance threshold of 3mm (adapted to the average distance between the gastric antrum and the body surface). The OLED display screen highlights the "gastric antrum positioning status".

[0129] External magnetic control device 200: Because the space in the gastric antrum is relatively open, the four sets of external magnets are adjusted to a spacing of 30mm along the guide rail and locked in position by fixing wire; when holding the arc-shaped handle, the external magnets are aligned with the surface projection area of ​​the gastric antrum in the upper abdomen (two finger widths above the navel and slightly to the right).

[0130] Magnetically Controlled Capsule 300: It uses an 8mm thick medical sponge with an adsorption structure (suitable for the volume of fluid in the stomach), and the filter membrane pore size is set to 0.22μm (to filter out food residue in the stomach), ensuring that only pure gastrointestinal fluid is collected.

[0131] III. Specific Operating Steps

[0132] After fasting for 6 hours, the patient swallowed 300 magnetically controlled capsules, and the magnetic induction device 100 was fixed to the patient's left wrist with a wristband and the control switch was turned on.

[0133] When the capsule reaches the antrum of the stomach with the peristalsis, the three-color LED light of the magnetic induction device turns green, the buzzer sounds an alarm, and the display shows "Antrum positioning successful, distance 2.8mm".

[0134] The operator holds the external magnetic control device 200 and aligns the external magnet with the target area on the upper abdomen, holding it for 2 minutes (to ensure that the adsorption structure fully absorbs the fluid in the antrum of the stomach).

[0135] Remove the external magnetic control device, reset and seal the capsule piston, and expel it with feces after 24 hours. Collect the capsule and disinfect it.

[0136] The capsule was disassembled, the adsorption structure was removed, and after elution with physiological saline and centrifugation, a gastrointestinal fluid sample from the antrum of the stomach was obtained for Helicobacter pylori nucleic acid detection and microbial diversity analysis.

[0137] Example 2

[0138] Sampling of the terminal ileum microbiota (suitable for monitoring inflammatory bowel disease)

[0139] I. Application Scenarios

[0140] For patients with Crohn's disease, intestinal fluid from multiple segments of the small intestine needs to be collected to analyze the dysbiosis in that area (such as changes in the ratio of Bifidobacteria and Clostridium perfringens), assess the activity of intestinal inflammation, and guide adjustments to clinical medication.

[0141] II. Adjustment of Device Parameters

[0142] Magnetic induction device 100: Activate the sensor group corresponding to "multi-segment small intestine" of the electromagnetic sensor, set the magnetic field strength detection chip to a preset distance threshold of 5mm, and adjust the vibration alarm module to strong vibration mode (to adapt to noisy outpatient environment).

[0143] External magnetic control device 200: For multiple segments of the small intestine with narrow lumens, the spacing between the four sets of external magnets is reduced to 15mm to enhance local magnetic force; the handle fits against the right side of the lower abdomen and uses anti-slip texture to maintain stability.

[0144] Magnetically Controlled Capsule 300: The inner wall of the upper capsule shell has a deeper drainage groove of 0.8mm (to accelerate the inflow of small amounts of intestinal fluid in multiple segments of the small intestine), and the adsorption structure uses a highly absorbent medical sponge (10mm thick) to ensure that sufficient samples can still be obtained in scenarios with small amounts of liquid.

[0145] III. Specific Operating Steps

[0146] After taking oral laxatives to cleanse the intestines, the patient swallowed 300 magnetically controlled capsules, wore a magnetic induction device 100, and rested in a supine position to reduce the peristaltic speed of the capsules.

[0147] Approximately 4 hours later, the magnetic induction device vibrated and alarmed, the LED light turned green, and the display screen indicated "Small intestine multi-segment positioning successful, distance 4.7mm".

[0148] The operator aims the external magnetic control device at the lower right side of the abdomen and holds it for 3 minutes (extend the adsorption time if the amount of intestinal fluid is small), during which time the sponge adsorption status is observed through the transparent capsule shell.

[0149] Remove the magnetic control device, reseal the capsule, and collect the expelled capsules after 48 hours, then disinfect the outer shell.

[0150] The capsule was disassembled to remove the adsorption structure. After washing and centrifugation, multiple small intestinal samples were obtained for the detection of the relative abundance of inflammation-related bacteria.

[0151] Example 3

[0152] Sampling of the splenic flexure of the colon (suitable for long-term monitoring of irritable bowel syndrome)

[0153] I. Application Scenarios

[0154] For long-term microecological monitoring of patients with irritable bowel syndrome (IBS), it is necessary to regularly collect gastrointestinal fluid from the splenic flexure of the colon (a region prone to intestinal flora imbalance), analyze the dynamic changes in the flora, and evaluate the effects of dietary or drug interventions.

[0155] II. Adjustment of Device Parameters

[0156] Magnetic induction device 100: Activates the sensor group corresponding to the "splenic flexure of the colon", the magnetic field strength detection chip is preset to a distance threshold of 4mm, and the OLED display screen enables the "historical positioning record" function, which can trace back the time and distance of the last 3 positioning times.

[0157] External magnetic control device 200: The splenic flexure of the colon is located in the left upper abdomen, and the lumen is twisted. The distance between the external magnets is adjusted to 25mm (to balance the coverage and magnetic strength). The handle is held against the left upper abdomen, and the anti-slip texture is used to prevent slippage during operation.

[0158] Magnetically controlled capsule 300: The information storage unit inside the lower capsule shell is used to write the patient ID and sampling date. The adsorption structure uses a slow-release medical sponge (adapted to the slow flow characteristics of fluid in the colon) to ensure a stable sample collection volume.

[0159] III. Specific Operating Steps

[0160] The patient followed a regular diet (avoiding high-fiber foods), swallowed 300 magnetically controlled capsules, and wore a magnetic induction device for 100 minutes while engaging in normal activities.

[0161] Approximately 12 hours later, the magnetic induction device alarmed, the LED light turned green, and the display screen showed "Splenic flexure of the colon successfully located, distance 3.8mm," while simultaneously recording the location time.

[0162] The operator holds the external magnetic control device to the upper left abdomen and holds it for 2.5 minutes. After confirming that the sponge is fully absorbed through the transparent shell, the device is removed.

[0163] After the capsule is excreted with feces, the capsule information is read using an electronic reader (to confirm the patient and sampling date), and the outer shell is disinfected.

[0164] The capsules were disassembled to extract samples, and the changing trends of colonic splenic flora (such as lactobacilli and bacteroides) were detected to provide a basis for adjusting the IBS intervention program. The above operation was repeated at one-month intervals to complete long-term dynamic monitoring.

[0165] The examples provided in this invention are not intended to limit the implementation. Those skilled in the art will recognize that various variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations, and any obvious variations or modifications derived therefrom are still within the scope of this invention.

Claims

1. A digestive tract microecological sampling device, characterized in that, The device includes a magnetic induction device (100), an external magnetic control device (200), and a magnetically controlled capsule (300). The magnetic induction device (100) is magnetically connected to the magnetically controlled capsule (300), and the external magnetic control device (200) is magnetically anchored to the magnetically controlled capsule (300). The magnetic induction device (100) includes a magnetic induction housing (101). The magnetic induction housing (101) is externally connected to a buzzer alarm (102), an OLED display screen (103), a control switch (104), a light alarm (105), and multiple sets of electromagnetic sensors (110). The magnetic induction housing (101) is internally connected to a power supply (106), a vibration alarm module (107), and a magnetic field strength detection chip (108). The OLED display (103), control switch (104), power supply (106), magnetic field strength detection chip (108), and MCU microcontroller (109) are connected in series to form a control loop. The buzzer alarm (102), OLED display (103), light alarm (105), vibration alarm module (107), magnetic field strength detection chip (108), and electromagnetic sensor (110) are electrically connected to the MCU microcontroller (109). The external magnetic control device (200) includes an external magnetic control housing (201), and multiple sets of circumferentially distributed guide rails (202) are connected inside the external magnetic control housing (201). The top of the guide rail (202) is provided with a sliding groove (203), and a sliding rod (205) is slidably connected in the sliding groove (203). The top of the sliding rod (205) is connected to an external magnet (204) disposed on the top of the guide rail (202). The side of the guide rail (202) is provided with a positioning groove (206) communicating with the sliding groove (203). The sliding rod (205) is positioned and connected to the guide rail (202) by a fixing wire (207) passing through the positioning groove (206). The magnetically controlled capsule (300) includes an upper capsule shell (301) and a lower capsule shell (313) detachably connected to the upper capsule shell (301). The end of the upper capsule shell (301) away from the lower capsule shell (313) An opening (303) for draining gastrointestinal fluid is provided; a compartment partition (308) is connected inside the lower capsule shell (313), and an inner shaft (311) is inserted into the compartment partition (308). One end of the inner shaft (311) is connected to the inner end of the lower capsule shell (313); an inner magnet (309) is provided on the side of the compartment partition (308) away from the upper capsule shell (301), and the inner magnet (309) is sleeved on the outside of the inner shaft (311); a compression spring (310) is provided on the side of the inner magnet (309) away from the compartment partition (308), and the compression spring (310) is sleeved on the outside of the inner shaft (311), and one end of it is connected to the inner end of the lower capsule shell (313);The upper capsule shell (301) is provided with an outer shaft (305), which is sleeved on the outside of the inner shaft (311) and passes through the compartment partition (308). One end of the outer shaft (305) is connected to the inner magnet (309), and the other end is connected to a piston (304) for sealing the opening (303). In the resting state, the pressure of the compression spring (310) pushes the inner magnet (309) to move towards the upper capsule shell (301), causing the outer shaft (305) and piston (304) to seal the opening (303). In the active state, the inner magnet (309) is attracted and fixed to the target intestinal wall by the outer magnet (204), pulling the outer shaft (305) and piston (304) to move towards the lower capsule shell (313), causing the piston (304) to disengage from the opening (303).

2. The digestive tract microecological sampling device according to claim 1, characterized in that, The bottom of the magnetic induction housing (101) is connected to a wristband connector (111), and the wristband connector (111) is detachably connected to a wristband (112). The two ends of the wristband (112) are connected by Velcro (113) to fix the device to the user's wrist.

3. The digestive tract microecological sampling device according to claim 1, characterized in that, The light alarm (105) is a three-color LED light, which uses red, yellow and green to respectively indicate the status of "not located", "approaching target" and "located successfully".

4. The digestive tract microecological sampling device according to claim 1, characterized in that, The external magnetic control shell (201) is a protective shell that can block magnetic fields. The top of the external magnetic control shell (201) is detachably connected to a control shell cover (208), and the bottom of the external magnetic control shell (201) is connected to an arc-shaped grip structure (209). The surface of the arc-shaped grip structure (209) is covered with anti-slip texture (210).

5. A digestive tract microecological sampling device according to claim 1, characterized in that, The inner wall of the upper capsule shell (301) is provided with multiple sets of guide grooves (302).

6. The digestive tract microecological sampling device according to claim 1, characterized in that, An adsorption structure (307) is connected inside the upper capsule shell (301). The adsorption structure (307) is used to adsorb gastrointestinal fluid around the magnetically controlled capsule (300). A filter membrane (306) is connected to the outside of the adsorption structure (307). The adsorption structure (307) is a sterile or sterilized adsorption material.

7. The digestive tract microecological sampling device according to claim 1, characterized in that, The piston (304) is an elastic seal, and the compression spring (310) is a mechanical reset component.

8. A digestive tract microecological sampling device according to claim 1, characterized in that, The lower capsule shell (313) is detachably connected to the upper capsule shell (301) via a connecting sleeve (312).

9. A digestive tract microecological sampling device according to claim 8, characterized in that, An information storage unit (314) is connected inside the lower capsule shell (313).

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