Scalp hair follicle nursing dressing and preparation method thereof

Abstract

The invention provides scalp hair follicle nursing dressing and a preparation method thereof.The preparation method comprises the steps that S100, raw materials including baicalin, adenosine, L-carnitine, water-soluble hair growing peptide and glucolactone are adopted, and a core material is prepared; s200, preparing a wall material from raw materials including lecithin, a soybean germ extract and a wheat germ extract; s300, mixing the core material and the wall material to prepare microcapsules; and S400, preparing the scalp hair follicle nursing dressing from raw materials including microcapsules, maltose acid, polyhydric alcohols and pepper extracts. In the scalp hair follicle nursing dressing obtained by the preparation method disclosed by the invention, the slow-release effects of the active components and the functional components are good, so that the scalp hair follicle nursing dressing obtained by the preparation method disclosed by the invention can exert the efficacy for a long time.

Description

Technical Field

[0001] This invention relates to the technical field of medical care products, and more specifically, to a scalp hair follicle care dressing and its preparation method. Background Technology

[0002] Currently, the incidence of scalp diseases such as seborrheic dermatitis and scalp psoriasis is increasing. These diseases are believed to be related to androgen-related increased sebum secretion, Malassezia colonization, and immune responses.

[0003] The above-mentioned diseases are mainly treated clinically with anti-inflammatory and antipruritic drugs, drugs to reduce sebum secretion, and antibacterial drugs. Anti-inflammatory and antipruritic drugs are mainly corticosteroid ointments. Drugs that control sebum secretion inhibit sebaceous gland activity and reduce secretion by regulating the differentiation and growth of epithelial cells. Antibacterial drugs are mainly topical antifungal agents, with ketoconazole lotion being the most commonly used at present.

[0004] Whether it's a hair care product that reduces sebum secretion or an antibacterial or anti-inflammatory drug combination, the problem encountered when applying them to scalp and hair follicle care is poor slow-release properties; they easily evaporate and are lost in a short time. Especially after shampooing, these substances are difficult to retain.

[0005] Therefore, how to improve the long-lasting and sustained-release properties of scalp hair follicle care dressings and increase their retention time in hair and hair follicle areas is a technical problem that urgently needs to be solved by those skilled in the art. Summary of the Invention

[0006] The problem addressed by this invention is how to improve the long-lasting, sustained-release properties of scalp hair follicle care dressings and increase their retention time in the hair and hair follicle areas.

[0007] To address the above problems, this invention provides a method for preparing a scalp hair follicle care dressing, comprising:

[0008] S100: The core material is prepared using raw materials including baicalin, adenosine, L-carnitine, water-soluble hair growth peptide, and gluconolactone.

[0009] S200: A wall material is prepared using raw materials including lecithin, soybean germ extract, and wheat germ extract.

[0010] S300: Mix the core material and the wall material to prepare a microcapsule emulsion;

[0011] S400: A scalp follicle care dressing is prepared using raw materials including microcapsule emulsion, maltodextrin, glycerin, and pepper extract.

[0012] In any of the above technical solutions, S100 includes:

[0013] S110. Sodium ethoxide, cyclodextrin, and glycerol are mixed evenly at a temperature of 22°C to 26°C to obtain a first mixture;

[0014] S120. Acryloyl chloride is added dropwise to the first mixture and kept at 2°C to 4°C while stirring. After the addition is complete, the temperature is stopped and the mixture is stirred for 12 to 16 hours. The solids are filtered, washed, and dried to obtain modified cyclodextrin.

[0015] S130. Baicalin, adenosine, L-carnitine, modified cyclodextrin, ammonium bicarbonate and water are mixed and fed into a reaction vessel for heating and pressurization to obtain a second mixture.

[0016] S140. Take out the second mixture and mix the water-soluble hair growth peptide, gluconolactone, the second mixture and water evenly to obtain the core material.

[0017] In any of the above technical solutions, in S110, sodium ethoxide: cyclodextrin: glycerol = (1-1.5): (8-12): 100; and / or in S120, acryloyl chloride: first mixture = (2-6): 100; and / or in S130, baicalin: adenosine: L-carnitine: ammonium bicarbonate: modified cyclodextrin: water = (2-8): (2-8): (2-8): (4-10): 100: 100; and / or in S140, water-soluble hair-growth peptide: gluconolactone: second mixture: water = (6-8): (10-12): (60-80): 100.

[0018] In any of the above technical solutions, S130 specifically includes:

[0019] S131. Baicalin, adenosine, L-carnitine, ammonium bicarbonate, modified cyclodextrin, and water are mixed and fed into a reaction vessel according to the mass ratio of baicalin: adenosine: L-carnitine: ammonium bicarbonate: modified cyclodextrin: water = (2-8): (2-8): (2-8): (4-10): 100: 100.

[0020] S132. Heat the reactor to 50°C to 55°C and keep it at that temperature for 1 hour.

[0021] S133. Cool the reactor to a temperature of 32°C to 36°C and pressurize it to a pressure of 7.4MPa to 8.0MPa. Maintain this pressure for 2 hours, then depressurize and cool to obtain the second mixture.

[0022] In any of the above technical solutions, S200 specifically includes:

[0023] S210. Mix lecithin, soybean germ extract, wheat germ extract and vegetable oil to obtain a third mixture;

[0024] S220. The third mixture is ultrasonically emulsified to obtain a wall material.

[0025] In any of the above technical solutions, in S210, lecithin: soybean germ extract: wheat germ extract: vegetable oil = (3-6):(4-10):(4-10):100; and / or in S210, the vegetable oil is at least one of the following or a combination thereof: shea butter, olive oil, avocado oil, coconut oil, palm oil; and / or in S220, the ultrasonic emulsification power is 200W to 400W, and the ultrasonic emulsification time is 4min to 10min.

[0026] In any of the above technical solutions, S300 specifically includes:

[0027] S310. Heat the core material to 35°C to 40°C. Add the wall material dropwise into the core material at a mass ratio of core material: wall material = (40-60): 100 and stir simultaneously. After the addition is complete, a fourth mixture is obtained.

[0028] S320. Sodium dodecyl sulfate is added to the fourth mixture at a mass ratio of (2-6):100, and homogenized at 3000 rpm / min to 3500 rpm / min for 5 min to 15 min to obtain a microcapsule emulsion.

[0029] In any of the above technical solutions, S400 specifically includes:

[0030] S410. Mix pepper extract, maltose, microcapsule emulsion, and glycerin evenly in water at 50°C to 60°C to prepare a scalp follicle care dressing.

[0031] In any of the above technical solutions, in S410, the ratio of pepper extract: maltose acid: microcapsule emulsion: glycerin: water = (0.05-0.5): (0.2-2): (10-15): (10-20): 30.

[0032] The present invention also provides a scalp hair follicle care dressing, which is obtained by the preparation method of any of the above technical solutions.

[0033] Beneficial effects

[0034] This invention provides a method for preparing a scalp follicle care dressing. First, a core material is prepared using raw materials including baicalin, adenosine, L-carnitine, water-soluble hair-growth peptides, and gluconolactone. Then, a wall material is prepared using raw materials including lecithin, soybean germ extract, and wheat germ extract. Subsequently, the core material and wall material are mixed to prepare a microcapsule emulsion. Finally, the scalp follicle care dressing is prepared using raw materials including the microcapsule emulsion, maltose phosphate, glycerin, and pepper extract. Given that the functional components in the scalp follicle care dressing are diverse and need to work together, but their physicochemical properties and mechanisms of action differ, this invention selects to prepare the functional components as microcapsule core materials or wall materials, or directly formulates them as non-microcapsule components, based on the properties and types of the functional components used. Specifically, pepper extract promotes the penetration of active ingredients into hair follicles, while maltodextrin softens the keratin near the scalp hair follicles and reduces sebum secretion. Therefore, both are directly added and dispersed in the scalp hair follicle care dressing. The remaining ingredients are prepared as microcapsules to enhance their long-lasting, sustained-release properties. Functionally, baicalin, adenosine, and L-carnitine need to work synergistically. In terms of physicochemical properties, baicalin is poorly soluble in both water and organic solvents; adenosine and L-carnitine are highly soluble in water. Therefore, the problem with baicalin is its tendency to aggregate and precipitate in the scalp hair follicle care dressing, while the problem with adenosine and L-carnitine is their tendency to be lost between hairs with water. Based on the functional effects and physicochemical properties of the aforementioned functional components, this invention uses baicalin, adenosine, and L-carnitine as the core material of microcapsules. By encapsulating the core material in the microcapsule structure, the release time of these functional components is delayed, increasing their retention time in hair and hair follicles, thus enabling them to fully and effectively enhance hair follicle cell activity and maintain hair follicle health. Lecithin not only promotes the penetration of active ingredients into hair follicles but also acts as an emulsifier in the microcapsule preparation process, reducing the repulsion between immiscible solutions and helping to form oil-soluble or water-soluble emulsions. Powdered soybean germ extract and wheat germ extract enhance hair follicle cell activity and delay cell aging. Both soybean germ extract and wheat germ extract are rich in natural vitamin E, linolenic acid, linoleic acid, squalene, octacosanol, and various physiologically active components, which can be relatively easily and stably dispersed in vegetable oils. A homogeneous oil-phase wall material can be obtained by uniformly dispersing soybean germ extract and wheat germ extract in vegetable oil. Piperine serves as a functional component that promotes the penetration of active ingredients into hair follicles, while maltodextrin softens the keratin near the hair follicles and reduces sebum secretion. In this embodiment of the invention, both are added in a non-microencapsulated form to promote their rapid and early action on the hair follicles. Therefore, this invention provides a scalp and hair follicle care dressing containing microcapsules, prepared according to the properties and types of each functional component. This dressing exhibits excellent long-lasting sustained-release properties of its functional components, allowing it to remain in the hair and hair follicle area for a longer period. Detailed Implementation

[0035] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, a detailed description of specific embodiments of the present invention will be provided below.

[0036] In the field of scalp and hair follicle care dressings, whether the ingredients are health-promoting or medicinal, the problem encountered when applied to the scalp and hair follicles is poor sustained-release performance, leading to easy evaporation and loss within a short period. This is especially true after shampooing, where these substances are difficult to retain.

[0037] Microencapsulation technology is an effective solution to the aforementioned problems. In recent years, the rapidly developing microencapsulation technology has been widely applied in fields such as pharmaceuticals, food, pesticides, textiles, and cosmetics. Through microencapsulation, solids, liquids, and even gases can be encapsulated in tiny capsules. The wall material effectively prevents damage to the core material from external environmental factors and effectively controls the release of the core material, maximizing its performance. Furthermore, microencapsulation technology can also mask tastes and odors, eliminating unpleasant smells from the core material.

[0038] However, existing technologies have shortcomings: the functional components in scalp and hair follicle care dressings are diverse and work together, with varying physicochemical properties and mechanisms of action. Therefore, only by formulating and adjusting the core and wall material components of microcapsules according to the properties and types of each functional component can an effective and long-lasting sustained-release scalp and hair follicle care dressing be produced, allowing it to remain on the hair and hair follicles for a longer period and fully exert its nourishing or therapeutic functions.

[0039] To achieve the above objectives, embodiments of the present invention provide a method for preparing a scalp hair follicle care dressing, comprising:

[0040] S100: The core material is prepared using raw materials including baicalin, adenosine, L-carnitine, water-soluble hair growth peptide, and gluconolactone.

[0041] S200: A wall material is prepared using raw materials including lecithin, soybean germ extract, and wheat germ extract.

[0042] S300: Mix the core material and the wall material to prepare a microcapsule emulsion;

[0043] S400: A scalp follicle care dressing is prepared using raw materials including microcapsule emulsion, maltodextrin, glycerin, and pepper extract.

[0044] Baicalin is a flavonoid compound extracted and isolated from the dried root of Scutellaria baicalensis, a plant of the Lamiaceae family. It has significant biological activity and antibacterial and anti-inflammatory effects.

[0045] Adenosine is a nutritional supplement that is widely used in skin care lotions for conditioning, anti-aging, anti-wrinkle, and whitening. It can stimulate hair growth, inhibit dandruff production, and interfere with viral nucleic acid synthesis. It is an active ingredient in traditional Chinese medicine for antiviral purposes and also has antibacterial and anti-inflammatory effects.

[0046] L-carnitine is an amino acid-like compound belonging to the quaternary ammonium cationic complex. It can be synthesized from lysine and methionine through biosynthesis and is involved in the metabolism of fat into energy in the body.

[0047] In this embodiment of the invention, the addition of baicalin helps to enhance hair follicle cell activity and delay cell aging. Adenosine and L-carnitine can enhance the transmission of chemical information between dermal papilla cells, activate keratin genes, promote keratin expression, and maintain hair follicle health.

[0048] In terms of functional effects, baicalin, adenosine, and L-carnitine need to work synergistically. Regarding physicochemical properties, baicalin is poorly soluble in both water and organic solvents; adenosine and L-carnitine, on the other hand, are highly soluble in water. Therefore, a problem with baicalin is its tendency to aggregate and precipitate in scalp and hair follicle care dressings, while adenosine and L-carnitine are prone to being lost through the hair shaft with water. Based on the functional effects and physicochemical properties of the above-mentioned components, this invention uses baicalin, adenosine, and L-carnitine as the core material of microcapsules. By encapsulating the core material in the microcapsule structure, the release time of these functional components is delayed, increasing their retention time in the hair and hair follicle, thus enabling them to fully and effectively enhance hair follicle cell activity and maintain hair follicle health over a longer period.

[0049] In a preferred embodiment of the present invention, S100 includes:

[0050] S110. Sodium ethoxide, cyclodextrin, and glycerol are mixed evenly at a temperature of 22°C to 26°C to obtain a first mixture;

[0051] S120. Acryloyl chloride is added dropwise to the first mixture and kept at 2°C to 4°C while stirring. After the addition is complete, the temperature is stopped and the mixture is stirred for 12 to 16 hours. The solids are filtered, washed, and dried to obtain modified cyclodextrin.

[0052] S130. Baicalin, adenosine, L-carnitine, modified cyclodextrin, ammonium bicarbonate and water are mixed and fed into a reaction vessel for heating and pressurization to obtain a second mixture.

[0053] S140. Take out the second mixture and mix the water-soluble hair growth peptide, gluconolactone, the second mixture and water evenly to obtain the core material.

[0054] In terms of microstructure, cyclodextrin has a hollow cylindrical three-dimensional ring structure. In this embodiment of the invention, the pores allow for the embedding of insoluble baicalin, and the hydrophilicity and porosity of cyclodextrin enable the loading of adenosine and L-carnitine. Although cyclodextrin has the above advantages, given its excellent solubility and tendency to disperse and disintegrate in liquid compositions, this embodiment of the invention uses it in combination with baicalin, adenosine, and L-carnitine as a core material.

[0055] In S110, sodium ethoxide: cyclodextrin: glycerol = (1-1.5): (8-12): 100.

[0056] Preferably, in S110, the ratio of sodium ethoxide: cyclodextrin: glycerol is 1:10:100.

[0057] In S120, acryloyl chloride: first mixture = (2-6): 100.

[0058] Preferably, in S120, acryloyl chloride: first mixture = 4:100.

[0059] In S130, baicalin: adenosine: L-carnitine: ammonium bicarbonate: modified cyclodextrin: water = (2-8): (2-8): (2-8): (4-10): 100: 100.

[0060] Preferably, in S130, the ratio of baicalin: adenosine: L-carnitine: ammonium bicarbonate: modified cyclodextrin: water is 4:4:6:8:100:100.

[0061] In S140, the water-soluble hair growth peptide: gluconolactone: second mixture: water = (6-8): (10-12): (60-80): 100.

[0062] Preferably, in S140, the ratio of water-soluble hair growth peptide: gluconolactone: second mixture: water is 6:10:60:100.

[0063] In S100, glycerol is used as a solvent, sodium ethoxide as an organic base, and acryloyl chloride as an acylation modifier. Acylated modified cyclodextrin can be obtained by uniformly mixing sodium ethoxide, cyclodextrin, and glycerol, followed by dropwise addition of acryloyl chloride and stirring the reaction mixture. Acylation treatment can modify the hydroxyl groups of cyclodextrin, improving its affinity and adsorption performance for baicalin, adenosine, and L-carnitine.

[0064] In a preferred embodiment of the present invention, S130 specifically includes:

[0065] S131. Baicalin, adenosine, L-carnitine, ammonium bicarbonate, modified cyclodextrin, and water are mixed and fed into a reaction vessel according to the mass ratio of baicalin: adenosine: L-carnitine: ammonium bicarbonate: modified cyclodextrin: water = (2-8): (2-8): (2-8): (4-10): 100: 100.

[0066] S132. Heat the reactor to 50°C to 55°C and keep it at that temperature for 1 hour.

[0067] S133. Cool the reactor to a temperature of 32°C to 36°C and pressurize it to a pressure of 7.4MPa to 8.0MPa. Maintain this pressure for 2 hours, then depressurize and cool to obtain the second mixture.

[0068] The purpose of heating and pressurizing the mixture of baicalin, adenosine, L-carnitine, ammonium bicarbonate, modified cyclodextrin, and water using the above-described S131 to S133 methods is to further improve the loading and dispersion uniformity of the functional components of baicalin, adenosine, and L-carnitine in the pores of the modified cyclodextrin. This ensures that baicalin is uniformly dispersed in the scalp follicle care dressing, preventing agglomeration, and also prevents the functional components of adenosine and L-carnitine from flowing with the water, resulting in a long-lasting sustained release. The key to achieving the above objectives in this embodiment of the invention lies in adding ammonium bicarbonate to the reactor in S130. Ammonium bicarbonate begins to decompose thermally above 50°C, releasing carbon dioxide. Under the sealed environment of the reactor, the temperature conditions of 32°C to 36°C and the pressure conditions of 7.4 MPa to 8.0 MPa allow the carbon dioxide to reach a supercritical state. The special interfacial properties of supercritical carbon dioxide can promote the uniform dispersion of baicalin, adenosine, and L-carnitine in the pores of the modified cyclodextrin, thereby achieving the above objectives.

[0069] In some embodiments of the present invention, S200 specifically includes:

[0070] S210. Mix lecithin, soybean germ extract, wheat germ extract and vegetable oil to obtain a third mixture;

[0071] S220. The third mixture is ultrasonically emulsified to obtain a wall material.

[0072] Preferably, in S210, the ratio of lecithin: soybean germ extract: wheat germ extract: vegetable oil is (3-6): (4-10): (4-10): 100.

[0073] Preferably, in S210, the vegetable oil is at least one of the following or a combination thereof: shea butter, olive oil, avocado oil, coconut oil, and palm oil.

[0074] Preferably, in S220, the power of ultrasonic emulsification is 200W to 400W, and the ultrasonic emulsification time is 4min to 10min.

[0075] Lecithin not only promotes the penetration of active ingredients into hair follicles but also acts as an emulsifier in the microcapsule preparation process, reducing the repulsion between immiscible liquids and helping to form oil-soluble or water-soluble emulsions. Powdered soybean germ extract and wheat germ extract enhance hair follicle cell activity and delay cell aging. Both soybean germ extract and wheat germ extract are rich in natural vitamin E, linolenic acid, linoleic acid, squalene, octacosanol, and various physiologically active components, which can be relatively easily and stably dispersed uniformly in vegetable oils. By uniformly dispersing soybean germ extract and wheat germ extract in vegetable oils, a homogeneous oil-phase wall material can be obtained.

[0076] In some embodiments of the present invention, S300 specifically includes:

[0077] S310. Heat the core material to 35°C to 40°C. Add the wall material dropwise into the core material at a mass ratio of core material: wall material = (40-60): 100 and stir simultaneously. After the addition is complete, a fourth mixture is obtained.

[0078] S320. Sodium dodecyl sulfate is added to the fourth mixture at a mass ratio of (2-6):100, and homogenized at 3000 rpm / min to 3500 rpm / min for 5 min to 15 min to obtain a microcapsule emulsion.

[0079] Preferably, in S310, the core material: wall material = 45:100.

[0080] Preferably, in S320, sodium dodecyl sulfate: fourth mixture = 2:100.

[0081] In this embodiment of the invention, by dripping the wall material into the core material and stirring simultaneously, a scalp and hair follicle care lotion with uniform and stable distribution of various functional components can be obtained.

[0082] In some embodiments of the present invention, S400 specifically includes:

[0083] S410. Mix pepper extract, maltose, microcapsule emulsion, and glycerin evenly in water at 50°C to 60°C to prepare a scalp follicle care dressing.

[0084] Preferably, in S410, the ratio of pepper extract: maltose: microcapsule emulsion: glycerin: water is (0.05-0.5): (0.2-2): (10-15): (10-20): 30.

[0085] Piperine serves as a functional component that promotes the penetration of active ingredients into the hair follicles, while maltodextrin softens the keratin near the hair follicles and reduces sebum secretion. In this embodiment of the invention, both are added in a non-microencapsulated form to facilitate their rapid and early action on the hair follicles.

[0086] It is understood that, in addition to the components mentioned above, those skilled in the art may add thickeners, moisturizers, preservatives, and other excipients to the scalp follicle care dressing as needed, according to actual requirements. The type and amount of such components can be selected and adjusted by those skilled in the art according to actual needs.

[0087] Example 1

[0088] This invention provides a method for preparing a scalp hair follicle care dressing, which includes the following steps:

[0089] S1. Sodium ethoxide: cyclodextrin: glycerol = 1:10:100 by mass. Sodium ethoxide, cyclodextrin and glycerol are magnetically stirred at 400 rpm / min for 10 min at 25°C to obtain the first mixture.

[0090] S2. Acryloyl chloride: first mixture = 4:100 by mass ratio. Acryloyl chloride is added dropwise to the first mixture which is kept at 2°C to 4°C and magnetically stirred at 800 rpm / min for 15 min. After the addition is complete, the temperature is stopped and the mixture is stirred for 12 h. The solids are filtered, washed with acetone 2 to 3 times, and dried with infrared radiation to obtain modified cyclodextrin.

[0091] S3. According to the mass ratio of baicalin: adenosine: L-carnitine: ammonium bicarbonate: modified cyclodextrin: water = 4:4:6:8:100:100, mix baicalin, adenosine, L-carnitine, ammonium bicarbonate, modified cyclodextrin and water and send them into the reaction vessel.

[0092] S4. Heat the reactor to 52±1℃ and keep it at that temperature for 1 hour;

[0093] S5. Cool the reactor to a temperature of 34±1℃ and pressurize it to a pressure of 7.4MPa to 7.6MPa, maintain the pressure for 2 hours, depressurize and allow it to cool naturally to obtain the second mixture. The pressurization is achieved by introducing nitrogen gas.

[0094] S6. Take out the second mixture and mix the water-soluble hair growth peptide, gluconolactone, second mixture and water according to the mass ratio of water-soluble hair growth peptide: gluconolactone: second mixture: water = 6:10:60:100. Stir magnetically at 400 rpm / min for 10 min to obtain the core material.

[0095] S7. According to the mass ratio of lecithin: soybean germ extract: wheat germ extract: vegetable oil = (3-6): (4-10): (4-10): 100, lecithin, soybean germ extract, wheat germ extract and vegetable oil are mixed and ultrasonically homogenized to obtain a third mixture.

[0096] S8. The third mixture is ultrasonically emulsified uniformly to obtain the wall material, wherein the ultrasonic emulsification power is 300W and the ultrasonic emulsification time is 6min.

[0097] S9. Heat the core material to 35°C, and add the wall material dropwise into the core material at a mass ratio of core material: wall material = 45:100 while stirring simultaneously. After the addition is complete, a fourth mixture is obtained.

[0098] S10. Sodium dodecyl sulfate was added to the fourth mixture at a mass ratio of 2:100 and homogenized at 3200 rpm / min for 10 min to obtain the microcapsule emulsion.

[0099] S11. According to the mass ratio of pepper extract: maltodextrin: microcapsule emulsion: glycerin: water = (0.05-0.5): (0.2-2): (10-15): (10-20): 30, pepper extract, maltodextrin, microcapsule emulsion and glycerin are mixed evenly in water at 55±2℃ to prepare scalp hair follicle care dressing.

[0100] Example 2

[0101] This invention provides a method for preparing a scalp hair follicle care dressing, which includes the following steps:

[0102] S1. According to the mass ratio of baicalin: adenosine: L-carnitine: ammonium bicarbonate: cyclodextrin: water = 4:4:6:8:100:100, mix baicalin, adenosine, L-carnitine, ammonium bicarbonate, cyclodextrin and water and send them into the reaction vessel.

[0103] S2. Heat the reactor to 52±1℃ and keep it at that temperature for 1 hour;

[0104] S3. Cool the reactor to a temperature of 34±1℃ and pressurize it to a pressure of 7.4MPa to 7.6MPa, maintain the pressure for 2 hours, depressurize and allow it to cool naturally to obtain the second mixture. The pressurization is achieved by introducing nitrogen gas.

[0105] S4. Take out the second mixture and mix the water-soluble hair growth peptide, gluconolactone, second mixture and water according to the mass ratio of water-soluble hair growth peptide: gluconolactone: second mixture: water = 6:10:60:100. Stir magnetically at 400 rpm / min for 10 min to obtain the core material.

[0106] S5. According to the mass ratio of lecithin: soybean germ extract: wheat germ extract: vegetable oil = (3-6): (4-10): (4-10): 100, lecithin, soybean germ extract, wheat germ extract and vegetable oil are mixed and ultrasonically homogenized to obtain a third mixture.

[0107] S6. The third mixture is ultrasonically emulsified uniformly to obtain the wall material, wherein the ultrasonic emulsification power is 300W and the ultrasonic emulsification time is 6min.

[0108] S7. Heat the core material to 35°C, and add the wall material dropwise into the core material at a mass ratio of core material: wall material = 45:100 while stirring simultaneously. After the addition is complete, a fourth mixture is obtained.

[0109] S8. Sodium dodecyl sulfate was added to the fourth mixture at a mass ratio of 2:100 and homogenized at 3200 rpm / min for 10 min to obtain the microcapsule emulsion.

[0110] S9. According to the mass ratio of pepper extract: maltodextrin: microcapsule emulsion: glycerin: water = (0.05-0.5): (0.2-2): (10-15): (10-20): 30, pepper extract, maltodextrin, microcapsule emulsion and glycerin are mixed evenly in water at 55±2℃ to prepare scalp hair follicle care dressing.

[0111] Example 3

[0112] This invention provides a method for preparing a scalp hair follicle care dressing, which includes the following steps:

[0113] S1. According to the mass ratio of baicalin: adenosine: L-carnitine: cyclodextrin: water = 4:4:6:100:100, mix baicalin, adenosine, L-carnitine, cyclodextrin and water and send them into the reaction vessel.

[0114] S2. Cool the reactor to a temperature of 34±1℃ and pressurize it to a pressure of 7.4MPa to 7.6MPa, maintain the pressure for 2 hours, depressurize and allow it to cool naturally to obtain a second mixture. The pressurization is achieved by introducing nitrogen gas.

[0115] S3. Take out the second mixture and mix the water-soluble hair growth peptide, gluconolactone, second mixture and water according to the mass ratio of water-soluble hair growth peptide: gluconolactone: second mixture: water = 6:10:60:100. Stir magnetically at 400 rpm / min for 10 min to obtain the core material.

[0116] S4. According to the mass ratio of lecithin: soybean germ extract: wheat germ extract: vegetable oil = (3-6): (4-10): (4-10): 100, lecithin, soybean germ extract, wheat germ extract and vegetable oil are mixed and ultrasonically homogenized to obtain a third mixture.

[0117] S5. The third mixture is ultrasonically emulsified uniformly to obtain the wall material, wherein the ultrasonic emulsification power is 300W and the ultrasonic emulsification time is 6min.

[0118] S6. Heat the core material to 35°C, and add the wall material dropwise into the core material at a mass ratio of core material: wall material = 45:100 while stirring simultaneously. After the addition is complete, a fourth mixture is obtained.

[0119] S7. Sodium dodecyl sulfate was added to the fourth mixture at a mass ratio of 2:100 and homogenized at 3200 rpm / min for 10 min to obtain the microcapsule emulsion.

[0120] S8. According to the mass ratio of pepper extract: maltodextrin: microcapsule emulsion: glycerin: water = (0.05-0.5): (0.2-2): (10-15): (10-20): 30, pepper extract, maltodextrin, microcapsule emulsion and glycerin are mixed evenly in water at 55±2℃ to prepare scalp hair follicle care dressing.

[0121] Performance testing

[0122] Weigh 15g of each of the scalp follicle care dressing samples prepared in Examples 1-3 and place them in beakers. Take three 5g portions of human hair and immerse them in the samples prepared in Examples 1-3 for 1 hour. After 1 hour, remove the human hair portions and place each of the three portions in a beaker containing 50ml of water. Stir magnetically at 200rpm / min for 10 minutes. After stirring, sample the liquid in each of the three beakers and test the content of baicalin.

[0123] The method for testing baicalin content is as follows: Place 0.5g of each liquid sample in a 50ml volumetric flask, add tri-n-octylphosphine oxide ethanol solution (5wt% concentration), seal tightly, and sonicate for 1 min at a power of 200W and a frequency of 25kHz. Continue to dilute to volume with the same tri-n-octylphosphine oxide ethanol solution to obtain the sample solution. Filter the subsequent filtrate through a 0.45μm microporous membrane and use the filtrate as the test solution. Perform the same dissolution and dilution process on the baicalin reference standard to prepare a reference solution containing approximately 50μg of baicalin per ml. Inject both the reference solution and the sample solution into a high-performance chromatograph (HPLC) for determination, with an injection volume of 10μl. Use 2,4-dimethyl-3-pentanol as mobile phase A, tributyl phosphate as mobile phase B, and ethanol as mobile phase C for gradient elution. An INERTSUSTAIN C18 column (180 mm long, 3.0 mm inner diameter, 3 μm packed with 3 μm particles) was used. The column temperature was 25 °C, the flow rate was 0.8 ml / min, and the detection wavelength was 280 nm. The results showed that after washing the hair strands from the sample of Example 1 in beaker 1 (50 ml of water), the baicalin content in beaker 1 was 0.04 mg / L. After washing the hair strands from the sample of Example 2 in beaker 2 (50 ml of water), the baicalin content in beaker 2 was 0.11 mg / L. After washing the hair strands from the sample of Example 3 in beaker 3 (50 ml of water), the baicalin content in beaker 3 was 0.17 mg / L.

[0124] While the present invention has been disclosed above, it is not limited thereto. Any person skilled in the art can make various modifications and alterations without departing from the spirit and scope of the invention; therefore, the scope of protection of the present invention should be determined by the scope defined in the claims.

Claims

1. A method of preparing a scalp follicle care preparation, characterized in that, The preparation method comprises: S100, using raw materials including baicalin, adenosine, L-carnitine, water-soluble hair growth peptide and glucose lactone to prepare a core material; S200, using raw materials including lecithin, soybean germ extract and wheat germ extract to prepare a wall material; S300, mixing the core material and the wall material to prepare a microcapsule emulsion; S400, using raw materials including the microcapsule emulsion, maltol, glycerol and pepper extract to prepare the scalp hair follicle care preparation.

2. The production method according to claim 1, characterized by, S100 comprises: S110, uniformly mixing sodium ethoxide, cyclodextrin and glycerol at a temperature of 22-26°C to obtain a first mixture; S120, adding acryloyl chloride dropwise into the first mixture kept at 2-4°C and stirring, stopping the heat preservation after the dropwise addition is completed, and stirring for 12-16 hours, filtering the solid, washing and drying to obtain modified cyclodextrin; S130, mixing the baicalin, adenosine, L-carnitine, modified cyclodextrin, ammonium bicarbonate and water and feeding them into a reaction kettle for temperature and pressure treatment to obtain a second mixture; S140, taking out the second mixture and uniformly mixing the water-soluble hair growth peptide, glucose lactone, the second mixture and water to obtain the core material.

3. The preparation method according to claim 2, wherein in S110, sodium ethoxide: cyclodextrin: glycerol = (1-1.5): (8-12): 100; and / or in S120, acryloyl chloride: first mixture = (2-6): 100; and / or in S130, baicalin: adenosine: L-carnitine: ammonium bicarbonate: modified cyclodextrin: water = (2-8): (2-8): (2-8): (4-10): 100: 100; and / or in S140, water-soluble hair growth peptide: glucose lactone: second mixture: water = (6-8): (10-12): (60-80):

100. S130 specifically comprises: S131, mixing the baicalin, adenosine, L-carnitine, ammonium bicarbonate, modified cyclodextrin and water in a mass ratio of baicalin: adenosine: L-carnitine: ammonium bicarbonate: modified cyclodextrin: water = (2-8): (2-8): (2-8): (4-10): 100: 100 and feeding them into a reaction kettle; S132, heating the reaction kettle to 50-55°C and keeping for 1 hour; S133, cooling the reaction kettle to a temperature of 32-36°C and pressurizing to a pressure of 7.4-8.0 MPa, keeping for 2 hours, depressurizing and cooling to obtain the second mixture.

4. The production method according to claim 2, characterized by, S200 specifically comprises: S210, mixing the lecithin, soybean germ extract, wheat germ extract and vegetable oil to obtain a third mixture; S220, uniformly ultrasonic emulsifying the third mixture to obtain the wall material.

6. The preparation method according to claim 5, wherein 5. The preparation method according to claim 1, characterized in that, ​ ​ ​ ​ In S210, lecithin: soy germ extract: wheat germ extract: vegetable oil = (3-6):(4-10):(4-10):100; and / or In S210, the vegetable oil is at least one or a combination of the following: shea butter, olive oil, avocado oil, coconut oil, palm oil; and / or In S220, the power of the ultrasonic emulsification is 200W to 400W, and the time of the ultrasonic emulsification is 4min to 10min.

7. The preparation method according to claim 1, characterized in that, S300 specifically includes: S310, heating the core material to 35℃ to 40℃, adding the wall material into the core material at a mass ratio of core material: wall material = (40-60):100, and stirring synchronously, to obtain a fourth mixture; S320, adding sodium dodecyl sulfate into the fourth mixture at a mass ratio of sodium dodecyl sulfate: fourth mixture = (2-6):100, and homogenizing at 3000rpm / min to 3500rpm / min for 5min to 15min, to obtain the microcapsule emulsion.

8. The method of claim 1, wherein, S400 specifically includes: S410, mixing the pepper extract, the maltose acid, the microcapsule emulsion, and the glycerol in water at 50℃ to 60℃ to obtain the scalp follicle care preparation.

9. The production method according to claim 8, characterized by, In S410, pepper extract: maltose acid: microcapsule emulsion: glycerol: water = (0.05-0.5):(0.2-2):(10-15):(10-20):

30.

10. A scalp follicle care preparation, characterized in that The scalp follicle care preparation is obtained by the preparation method of any one of claims 1 to 9. The scalp follicle care preparation is obtained by the preparation method of any one of claims 1 to 9.