Encapsulated oil-in-water type composition and preparation method thereof

Abstract

The invention discloses an encapsulated oil-in-water type composition and a preparation method thereof. The encapsulated oil-in-water type composition comprises the following components in percentage by weight: 0.1-1% of retinol; the oil-phase thickening agent is selected from one or more of dextrin palmitate, a castor oil / IPDI (isophorone diisocyanate) copolymer, an HDI (hexamethylene diisocyanate) / trihydroxymethyl hexyl lactone cross-linked polymer, glyceryl behenate, a hydrogenated (styrene / butadiene) copolymer and dibutyl lauroyl glutamine; the oil-phase thickening agent is selected from one or more of dextrin palmitate, a castor oil / IPDI (isophorone diisocyanate) copolymer, an HDI (hexamethylene diisocyanate) / trihydroxymethyl hexyl lactone cross-linked polymer, glyceryl behenate, a hydrogenated (styrene / butadiene) copolymer and dibutyl lauroyl glutamine; 10%-20% of an oil component, wherein the oil component comprises caprylic acid / capric triglyceride; 0.1%-5% of a rheology modifier; 5-20% of a humectant; and the balance of water. The capsule product has good slow release property. According to the composition disclosed by the invention, high-content addition and high-efficacy performance of the retinol are realized, meanwhile, good formula stability can also be realized, and the problem of skin irritation caused by the retinol is improved.

Description

Technical Field

[0001] This invention relates to an encapsulated oil-in-water composition and its preparation method. Background Technology

[0002] With the rise of e-commerce platforms, the displayability of cosmetics has become a significant competitive factor. During live streams or video demonstrations, consumers are drawn to products with unique appearances. Therefore, there is a need to develop products that differentiate themselves from traditional creams, making them more competitive. Research has found that products with unique capsule-like packaging are more popular with consumers. This is partly due to their aesthetic appeal, and partly because the capsules suggest a higher concentration of active ingredients, encouraging consumers to choose more potent products for better results. Based on these factors, there is an urgent need in this field to develop a product with a unique capsule-like packaging.

[0003] Furthermore, in the cosmetics market, consumers are increasingly focusing on products with high efficacy and high content.

[0004] Retinol, widely recognized as a highly effective ingredient, has garnered increasing attention. However, due to its strong irritant properties, poor stability, and photosensitivity, it is difficult to use in formulations. Currently, few products on the market claim to contain retinol, and even those that do typically have a retinol content of only 0.1%-0.2% by weight.

[0005] Therefore, how to achieve a high content of retinol in capsule products is a technical problem that urgently needs to be solved in this field. Summary of the Invention

[0006] The technical problem to be solved by the present invention is to overcome the defects of low retinol content, high irritation and inability to fully exert its efficacy in existing cosmetic formulations, and to provide an encapsulated water-in-oil composition and its preparation method.

[0007] In this invention, retinol is applied to a capsule product, which has good sustained-release properties, enabling the retinol to achieve high content and high efficacy while also maintaining good formulation stability and improving the skin irritation problem caused by retinol.

[0008] The capsules in this invention are crystal clear, and both the hydrogel and oleogel have a transparent appearance, which is different from conventional semi-transparent or opaque capsules, increasing the product's aesthetics and improving the smoothness of the skin. Furthermore, in this invention, the oil phase component and the water phase component are dissolved by heating, and the oil phase component is added to the cooled water phase component at a high temperature, so there is no need to precisely control the temperature of the water phase or the oil phase to form a better appearance.

[0009] This invention provides an encapsulated oil-in-water composition, which, by weight percentage, comprises the following components:

[0010] 0.1-1% retinol;

[0011] 1-5% of an oil phase thickener, wherein the oil phase thickener is selected from one or more of dextrin palmitate, castor oil / IPDI copolymer, HDI / trimethylolhexyl lactone crosspolymer, glyceryl behenate, hydrogenated (styrene / butadiene) copolymer, and dibutyllauroyl glutamine;

[0012] 10%-20% oil components, including caprylic / capric triglycerides;

[0013] 0.1%-5% rheology modifier;

[0014] 5-20% humectant;

[0015] The remainder is water.

[0016] In this invention, the chemical formula of the retinol is C 20 H 30 O is one of the forms of vitamin A, CAS Registry Number 68-26-8.

[0017] In some preferred embodiments of the present invention, the retinol content is 0.4-0.7%.

[0018] In some preferred embodiments of the present invention, the retinol content is 0.1-0.5%, for example 0.1-0.3%, or even 0.1%, 0.2%, 0.3% or 0.5%.

[0019] In some embodiments of the present invention, the content of the oil phase thickener is 2-5%, for example 2-3%, or even 2%, 3%, or 5%.

[0020] In this invention, if the amount of oil-phase thickener is greater than 5%, the capsule will be difficult to spread, resulting in a poor user experience. Conversely, if the amount of oil-phase thickener is less than 1%, the capsule may fail to form properly.

[0021] In some embodiments of the present invention, the oil phase thickener is selected from castor oil / IPDI copolymer or HDI / trimethylolhexyl lactone crosslinked polymer.

[0022] In some embodiments of the present invention, the oil phase thickener is selected from castor oil / IPDI copolymer, and the content of castor oil / IPDI copolymer is 2-3%.

[0023] In some embodiments of the present invention, the oil phase thickener is selected from HDI / trimethylolhexyl lactone crosspolymer, and the content of HDI / trimethylolhexyl lactone crosspolymer is 2-3%.

[0024] In some embodiments of the present invention, the content of the oil component is 12-20%, for example 13-15%, or even 13%, 14% or 15%.

[0025] In some embodiments of the present invention, the oil components further include one or more of the following: cyclopentamethoxysiloxane, polydimethylsiloxane, octyl polymethylsiloxane, diphenylsiloxyphenyl polytrimethylsiloxane, phenyl polytrimethylsiloxane, methyl polytrimethylsiloxane, squalane, isohexadecane, isodecane, isononyl isononanoate, cetyl ethylhexanoate, diisostearyl malate, pentaerythritol tetra(ethylhexanoate), glyceryl tri(ethylhexanoate), neopentyl glycol didecanoate, hydrogenated polyisobutylene, ethylhexyl palmitate, octyl dodecanol, dioctyl carbonate, wild soybean oil, sweet almond oil, jojoba seed oil, olive fruit oil, meadowfoam seed oil, grape seed oil, camellia seed oil, and sunflower seed oil.

[0026] In some embodiments of the present invention, the oil component is selected from caprylic / capric triglyceride and "one or more of squalane, wild soybean oil, and polydimethylsiloxane"; for example, caprylic / capric triglyceride, squalane, and wild soybean oil; and also, for example, caprylic / capric triglyceride, squalane, wild soybean oil, and polydimethylsiloxane.

[0027] In some embodiments of the present invention, the oil component comprises 5% caprylic / capric triglyceride, 5% squalane, 1-2% wild soybean oil and 2% polydimethylsiloxane.

[0028] In some embodiments of the present invention, the oil component comprises 5% caprylic / capric triglycerides, 5% squalane, and 3-5% wild soybean oil.

[0029] In some embodiments of the present invention, the oil component contains 10% caprylic / capric triglyceride.

[0030] In some embodiments of the present invention, the content of the rheology modifier is 0.1-0.3%, for example 0.2-0.3%.

[0031] In this invention, a rheology modifier refers to an additive that can improve or control rheological properties such as viscosity.

[0032] In some embodiments of the present invention, the rheology modifier is selected from one or more of the following: acrylate / C10-30 alkanol acrylate crosspolymer, carbomer, ammonium acryloyldimethyl taurate / VP copolymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, sodium acrylate / sodium acryloyldimethyl taurate copolymer, sodium polyacrylate, polyacrylate crosspolymer-6, sodium polyacryloyldimethyl taurate, and acrylamide / sodium acryloyldimethyl taurate copolymer.

[0033] In some embodiments of the present invention, the rheology modifier is selected from acrylate / C10-30 alkanol acrylate crosslinked polymers.

[0034] In some embodiments of the present invention, the content of the humectant is 10-20%, for example 15%.

[0035] In some embodiments of the present invention, the humectant is selected from one or more of glycerin, 1,2-pentanediol, 1,2-hexanediol, 1,3-propanediol, and butylene glycol, for example, glycerin, 1,2-pentanediol, 1,2-hexanediol, and butylene glycol.

[0036] In some embodiments of the present invention, the humectant is selected from 10% glycerin, 2% 1,2-pentanediol, 1% 1,2-hexanediol and 2% butylene glycol.

[0037] In some embodiments of the present invention, the encapsulated oil-in-water composition further includes active ingredients other than retinol.

[0038] In some embodiments of the present invention, the content of active ingredients other than retinol is 1-5%, for example 1-2%, and also for example 1.1%, 1.2%, 1.3% or 1.5%.

[0039] In some embodiments of the present invention, the active ingredients other than retinol are selected from one or more of the following: witch hazel water, centella asiatica extract, purslane extract, 4-tert-butylcyclohexanol, bisabolol, dipotassium glycyrrhizate, allantoin, betaine, citrus fruit extract, gentian root extract, horse chestnut flower water, horse chestnut extract, coix seed extract, lactobacillus / mung bean seed extract / monosodium glutamate fermentation product filtrate, and carboxymethyl deacetylated chitosan; for example, purslane extract and / or 4-tert-butylcyclohexanol.

[0040] In some embodiments of the present invention, the active ingredients other than retinol are selected from 0.1-0.5% (e.g., 0.1%, 0.2%, 0.3% or 0.5%) of 4-tert-butylcyclohexanol and 1% of purslane extract.

[0041] In some embodiments of the present invention, the encapsulated oil-in-water composition further includes a pH adjuster.

[0042] In this invention, the purpose of adding the pH adjuster is to partially or completely neutralize some rheological properties. Modifiers, such as acrylate / C10-30 alkanol acrylate crosspolymers and carbomer, further extend the chain segments and provide some viscosity.

[0043] In some embodiments of the present invention, the content of the pH adjuster is 0.1-0.5%, for example 0.1-0.3%, or even 0.15% or 0.25%.

[0044] In some embodiments of the present invention, the pH adjuster is tromethamine.

[0045] In some embodiments of the present invention, the encapsulated water-in-oil composition further includes other trace ingredients acceptable in cosmetics.

[0046] In some embodiments of the present invention, the encapsulated oil-in-water composition is selected from any one of the following formulations 1-4, by weight percentage:

[0047]

[0048]

[0049] .

[0050] Unless otherwise specified, in this invention, "%" refers to the weight percentage in the encapsulated oil-in-water composition.

[0051] The present invention also provides a method for preparing the encapsulated oil-in-water composition, comprising the following steps:

[0052] Phase B is added to phase A and stirred to obtain a mixed phase. Then, phase C is added to the mixed phase to obtain the encapsulated oil-in-water composition.

[0053] Phase A may contain a portion of water and the humectant, or Phase A may contain a portion of water, the humectant, the pH adjuster, and the active ingredients other than retinol.

[0054] B comprises the retinol, the oil phase thickener, and the oil components;

[0055] The C phase comprises the rheology modifier and the remaining water.

[0056] In some embodiments of the present invention, the A phase is prepared by the following method:

[0057] Phase A is obtained by first mixing a portion of water and the aforementioned humectant.

[0058] Alternatively, phase A can be obtained by first mixing a portion of water, the moisturizer, the pH adjuster, and the active ingredients other than retinol.

[0059] In some embodiments of the present invention, the mass ratio of the partial water to the remaining water is (3-4):1, for example 3.56:1, 3.42:1, 3.52:1, 3.30:1 or 3.72:1.

[0060] In some embodiments of the present invention, the temperature of the first mixing is 60-80°C.

[0061] In some embodiments of the present invention, the B phase is prepared by the following method:

[0062] Phase B is obtained by a second mixing of the retinol, the oil phase thickener, and the oil components.

[0063] In some embodiments of the present invention, the temperature of the second mixing is 90-110°C.

[0064] In some embodiments of the present invention, the encapsulated oil-in-water composition is in the form of a hydrogel encapsulating an oleogel (capsule gel form).

[0065] Based on common knowledge in the field, the above-mentioned preferred conditions can be combined arbitrarily to obtain various preferred embodiments of the present invention.

[0066] The reagents and raw materials used in this invention are all commercially available.

[0067] The positive and progressive effects of this invention are as follows:

[0068] (1) The retinol-containing compositions (e.g., face creams) of the present invention have a special capsule-gel appearance, giving people a visual experience that visualizes the efficacy.

[0069] (2) The present invention significantly reduces the irritation to human skin through the water-oil dual gel, and the high content of retinol also has certain effects in soothing and repairing. Attached Figure Description

[0070] Figure 1 Figure A is a schematic diagram of the appearance of the capsule gel of the face cream prepared in Example 3, and Figure B is a photograph.

[0071] Figure 2 The images show the appearance of the face cream sample from Example 3 after being stored in constant temperature chambers at different temperatures (-18℃, -7℃, 4℃, 25℃, 37℃, 45℃, 50℃) for three months; and the appearance of the sample after being placed in a circulation chamber (circulated at -18 to 45℃, labeled "C") for a total of three cycles (6 days).

[0072] Figure 3 The images show the appearance of the non-encapsulated face cream sample from Comparative Example 1 after being stored in constant temperature chambers at different temperatures (-18℃, -7℃, 4℃, 25℃, 37℃, 45℃, 50℃) for three months; and the appearance of the sample after being placed in a circulating chamber (-18~45℃, labeled "C") for a total of three cycles (6 days).

[0073] Figure 4 The graph shows a comparison of the average hemoglobin concentration of the subjects in Example 3 before and after using the face cream sample of Example 3 for 2 weeks.

[0074] Figure 5 The images show a comparison of the skin appearance of the subjects in Example 3 before and after using the face cream sample of Example 3 for 2 weeks.

[0075] Figure 6 The graph shows a comparison of transdermal water loss values ​​in subjects of Example 3 before and after using the face cream sample of Example 3 for 2 weeks. Detailed Implementation

[0076] The present invention is further illustrated below by way of embodiments, but the invention is not limited to the scope of the embodiments described herein. Experimental methods in the following embodiments that do not specify specific conditions were performed according to conventional methods and conditions, or as selected according to the product instructions.

[0077] In the following embodiments and comparative examples:

[0078] All raw material ingredients are named using the INCI (International Nomenclature Cosmetic Ingredient) name.

[0079] Retinol: Chemical formula is C 20 H 30 O is one of the forms of vitamin A, CAS Registry Number 68-26-8;

[0080] Castor oil / IPDI copolymer: a compound copolymerized from castor oil and IPDI (isophorone diisocyanate);

[0081] HDI / Trimethylolhexyl lactone crosspolymer: is a compound formed by cross-linking HDI (hexamethylene diisocyanate) and trimethylolhexyl lactone;

[0082] Caprylic / capric triglyceride: CAS Registry No. 65381-09-1;

[0083] Squalane: CAS Registry No. 111-01-3;

[0084] Polydimethylsiloxane: a high molecular weight polymer with the chemical formula (C2H6OSi). n CAS Registry Number 9006-65-9.

[0085] Examples 1-5

[0086] Table 1. Raw material formulation for Examples 1-5 (by weight percentage)

[0087]

[0088]

[0089] The preparation method is as follows:

[0090] (1) Mix the components of phase A at 60-80℃ and then cool to room temperature for later use;

[0091] (2) Dissolve all components of phase B completely at 90-110℃, add the phase B mixture to the phase A mixture and stir (the mixing temperature of phase A and phase B is below 50℃), and then add phase C to the mixture of phase B and phase A to obtain a retinol face cream with hydrogel encapsulating oil gel (capsule gel form).

[0092] Comparative Example 1

[0093] Comparative Example 1 yielded a non-encapsulated face cream sample with the same formulation as Example 3.

[0094] Formula: as shown in Table 2 below.

[0095] Table 2 (by weight)

[0096]

[0097]

[0098] Preparation method:

[0099] Mix all components in phase A except for the active ingredient and dissolve them at 70-80℃;

[0100] Mix all components in phase B except for the active ingredient and dissolve them at 70-80℃;

[0101] Mix the components of phase C at room temperature;

[0102] After emulsifying the dissolved A and B phases at 70-80℃ for 5-8 minutes, add C to AB and mix for 3-5 minutes. Cool to 40-45℃, add the active ingredients from A and B phases, and then cool to below 30℃.

[0103] Comparative Example 2

[0104] Commercially available product: HBN Retinol Firming and Revitalizing Night Cream. Purchased from Shenzhen Hujia Technology Co., Ltd., product model number: Yue G Zhuangwang Bei Zi 2023229016.

[0105] Compared with Comparative Example 2, the encapsulated face creams in Examples 1-5 of the present invention have the following advantages:

[0106] (1) Appearance advantages: The capsules of the present invention are more crystal clear, and both hydrogel and oleogel have a transparent appearance, while HBN products present semi-transparent and opaque capsules.

[0107] (2) Advantages of active substances: The retinol content in this invention is above trace (≥0.1%), while the retinol content in HBN products is below trace (not exceeding 0.1%).

[0108] Example 1: Stability Test

[0109] 1) The retinol face cream with hydrogel encapsulated in oleogel prepared in Example 3 and the non-encapsulated face cream prepared in Comparative Example 1 were stored in constant temperature incubators at different temperatures (-18℃, -7℃, 4℃, 25℃, 37℃, 45℃, 50℃) and their appearance changes were observed after three months.

[0110] 2) The retinol face cream with hydrogel encapsulating oleogel prepared in Example 3 and the non-encapsulated face cream prepared in Comparative Example 1 were placed in a circulation chamber (-18 to 45°C) and tested for three cycles (6 days) to observe their appearance changes.

[0111] The test results of the retinol face cream containing hydrogel-encapsulated oleogel prepared in Example 3 are as follows: Figure 2 As shown, the non-encapsulated face cream prepared in Comparative Example 1 is as follows: Figure 3 As shown. Figure 2 , Figure 3 The groups marked -18℃, -7℃, 4℃, 25℃, 37℃, 45℃, and 50℃ respectively indicate that the items were stored at that temperature for three months. The group marked "C" indicates that the items were tested for three cycles (6 days) in a cyclic chamber (-18 to 45℃).

[0112] according to Figure 2 , Figure 3 It can be seen that after three months of stability testing, the encapsulated retinol cream still maintains good capsule size uniformity, and the color changes less compared to the unencapsulated retinol cream.

[0113] Example 2: Product Safety Test

[0114] Thirty subjects were selected. The following retinol creams were prepared: the hydrogel-encapsulated oil gel retinol cream prepared in Example 3; the hydrogel-encapsulated oil gel retinol cream prepared in Example 5; a commercially available sample (“HBN Retinol Firming and Revitalizing Night Cream” from Comparative Example 2); and the non-encapsulated retinol cream prepared in Comparative Example 1. The control group served as a blank control, receiving no treatment. The patch containing the test substance was applied to the flexor surface of the subject's forearm, and the palm was gently pressed to ensure even application to the skin. Continue for 24 hours; 30 min, 24 h, and 48 h after removing the test sample from the apparatus, according to the table. 3. Observe the skin irritation and sensitization, and record the observation results.

[0115] Table 3. Grading Criteria for Skin Reactions in Closed Patch Tests

[0116]

[0117] Table 4. Results of occlusive patch test (retinol cream group vs. control group)

[0118]

[0119] Table 5. Results of occlusive patch test (retinol cream group vs. control group)

[0120]

[0121]

[0122] Table 6. Results of closed patch test (competitive products vs. control group)

[0123]

[0124] Table 7 Results of the closed patch test (Comparative Example 1: Non-encapsulated face cream group vs. control group)

[0125]

[0126] Example 3 Clinical Test

[0127] 1. Subject information is shown in Table 8.

[0128] Table 8

[0129]

[0130]

[0131] 2. Test on the effect of improving redness and spider veins: The test content is shown in Table 9.

[0132] Table 9

[0133]

[0134]

[0135] Table 10

[0136]

[0137] Note: *There was a significant difference after 2 weeks of sample use compared with before sample use (p<0.05).

[0138] The results of the average heme concentration test are shown in Table 10. Figure 4 , Figure 5 As shown, compared with the baseline value before use, after using the retinol cream in Example 3 for two weeks, the redness of the face was significantly improved, and the average hemoglobin concentration decreased by 6.62%.

[0139] 3. Test on the effect of improving transepidermal water loss value (TEWL)

[0140] The test content is shown in Table 11.

[0141] Table 11

[0142]

[0143]

[0144]

[0145] Table 12

[0146]

[0147] Note: *There was a significant difference after 2 weeks of sample use compared with before sample use (p<0.05).

[0148] The test results of transdermal water loss are shown in Table 12. Figure 6 As shown, compared with the baseline value before use, transepidermal water loss decreased by 24.21% after two weeks of using the retinol cream in Example 3.

[0149] Conclusion: Based on the combined effects of Examples 1, 2, and 3, the retinol face cream of this invention not only did not cause skin irritation, but also showed good soothing and repairing effects.

Claims

1. An encapsulated oil-in-water composition, characterized in that, The encapsulated oil-in-water composition comprises the following components by weight percentage: 0.1-1% retinol; 1-5% of an oil phase thickener, wherein the oil phase thickener is selected from one or more of dextrin palmitate, castor oil / IPDI copolymer, HDI / trimethylolhexyl lactone crosspolymer, glyceryl behenate, hydrogenated (styrene / butadiene) copolymer, and dibutyllauroyl glutamine; 10%-20% oil components, including caprylic / capric triglycerides; 0.1%-5% rheology modifier; 5-20% humectant; The remainder is water.

2. The encapsulated oil-in-water composition as described in claim 1, characterized in that, The retinol content is 0.4-0.7% or 0.1-0.5%, for example 0.1-0.3%.

3. The encapsulated oil-in-water composition as described in claim 1, characterized in that, The content of the oil phase thickener is 2-5%, for example, 2-3%; And / or, the oil phase thickener is selected from castor oil / IPDI copolymer or HDI / trimethylolpropionic acid crosspolymer.

4. The encapsulated oil-in-water composition as described in claim 1, characterized in that, The content of the oil component is 12-20%, for example 13-15%; And / or, the oil components further include one or more of the following: cyclopentamethoxysiloxane, polydimethylsiloxane, octyl polymethylsiloxane, diphenylsiloxyphenyl polytrimethylsiloxane, phenyl polytrimethylsiloxane, methyl polytrimethylsiloxane, squalane, isohexadecane, isodecane, isononyl isononanoate, cetyl ethylhexanoate, diisostearyl malate, pentaerythritol tetra(ethylhexanoate), glyceryl tri(ethylhexanoate), neopentyl glycol didecanoate, hydrogenated polyisobutylene, ethylhexyl palmitate, octyl dodecanol, dioctyl carbonate, wild soybean oil, sweet almond oil, jojoba seed oil, olive fruit oil, meadowfoam seed oil, grape seed oil, camellia seed oil, and sunflower seed oil.

5. The encapsulated oil-in-water composition as described in claim 1, characterized in that, The oil components are selected from caprylic / capric triglycerides and "one or more of squalane, wild soybean oil, and polydimethylsiloxane"; for example, caprylic / capric triglycerides, squalane, and wild soybean oil; and also, for example, caprylic / capric triglycerides, squalane, wild soybean oil, and polydimethylsiloxane.

6. The encapsulated oil-in-water composition as described in claim 1, characterized in that, The content of the rheology modifier is 0.1-0.3%, for example 0.2-0.3%; And / or, the rheology modifier is selected from one or more of the following: acrylate / C10-30 alkanol acrylate crosspolymers, carbomer, ammonium acryloyldimethyl taurate / VP copolymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, sodium acrylate / sodium acryloyldimethyl taurate copolymer, sodium polyacrylate, polyacrylate crosspolymer-6, sodium polyacryloyldimethyl taurate, and acrylamide / sodium acryloyldimethyl taurate copolymer; for example, acrylate / C10-30 alkanol acrylate crosspolymers.

7. The encapsulated oil-in-water composition as described in claim 1, characterized in that, The content of the moisturizer is 10-20%, for example 10-15%; And / or, the humectant is selected from one or more of glycerin, 1,2-pentanediol, 1,2-hexanediol, 1,3-propanediol, and butylene glycol, for example, glycerin, 1,2-pentanediol, 1,2-hexanediol, and butylene glycol.

8. The encapsulated water-in-oil composition according to any one of claims 1-7, characterized in that, The encapsulated oil-in-water composition also includes active ingredients other than retinol and / or pH adjusters; The content of the active ingredients other than retinol may be 1-5%, for example 1-2%; The active ingredients, excluding retinol, may be selected from one or more of the following: witch hazel water, centella asiatica extract, purslane extract, 4-tert-butylcyclohexanol, bisabolol, dipotassium glycyrrhizate, allantoin, betaine, citrus fruit extract, gentian root extract, horse chestnut flower water, horse chestnut extract, coix seed extract, lactobacillus / mung bean seed extract / monosodium glutamate fermentation product filtrate, and carboxymethyl deacetylated chitosan; for example, purslane extract and / or 4-tert-butylcyclohexanol; The content of the pH adjuster may be 0.1-0.5%, for example 0.1-0.3%; The pH adjuster may be tromethamine.

9. A method for preparing an encapsulated water-in-oil composition as described in any one of claims 1-8, characterized in that, It includes the following steps: Phase B is added to phase A and stirred to obtain a mixed phase. Then, phase C is added to the mixed phase to obtain the encapsulated oil-in-water composition. Phase A may contain a portion of water and the humectant, or Phase A may contain a portion of water, the humectant, the pH adjuster, and the active ingredients other than retinol. Phase B comprises the retinol, the oil phase thickener, and the oil components; The C phase comprises the rheology modifier and the remaining water.

10. The method for preparing the encapsulated oil-in-water composition as described in claim 9, characterized in that, Phase A is prepared by the following method: Phase A is obtained by first mixing a portion of water and the moisturizer; or, Phase A is obtained by first mixing a portion of water, the moisturizer, the pH adjuster, and the active ingredients other than retinol; the temperature of the first mixing is 60-80℃. And / or, the B phase is prepared by the following method: the retinol, the oil phase thickener, and the oil components are mixed a second time to obtain the B phase; the temperature of the second mixing is 90-110°C; And / or, the mass ratio of the portion of water to the remaining portion of water is (3-4):1, for example (3.40-3.80):1.

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