Medicine for improving essence, qi and spirit and preparation method thereof
By preparing an oral liquid containing ginseng and other traditional Chinese medicinal herbs, mitochondrial damage was repaired, solving the problem of insufficient energy and spirit caused by modern life, and achieving weight gain, improved exercise endurance and health recovery.
Patent Information
- Application Number
- CN202411092406.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-09
- Publication Date
- 2026-02-03
AI Technical Summary
The pressures of modern urban life lead to a decline in people's physical fitness, manifested as a lack of energy and vitality, and a lack of effective traditional Chinese medicine prescriptions to improve energy, vitality, and health.
This oral liquid is made from Chinese medicinal herbs such as ginseng, astragalus, wolfberry, privet fruit, rosehip, dodder seed, polygonatum, white peony root, licorice, malt, and epimedium. It is prepared by water extraction, vacuum low-temperature concentration, alcohol precipitation, and the addition of honey. It repairs mitochondrial damage and enhances vitality.
It significantly increases weight, improves exercise endurance and physical strength, repairs mitochondrial structure, reduces cristae damage and mitochondrial swelling, and enhances energy and vitality.
Smart Images
Figure CN121445828A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of biomedical technology, and in particular to a drug for enhancing vitality and a method for its preparation. Background Technology
[0002] The increasing pressure of modern urban life and unhealthy lifestyle habits such as staying up late, lack of exercise, overwork, and improper diet lead to a decline in physical fitness, resulting in frequent feelings of fatigue, poor appetite, and weight loss. In Traditional Chinese Medicine terms, these are all manifestations of a lack of vital energy (qi) and spirit.
[0003] The balance and harmony of vital energy (qi) and spirit are essential for maintaining physical and mental health. By maintaining this balance and vitality, people can achieve harmony of mind and body, improve their quality of life, and prevent various health problems.
[0004] Therefore, Traditional Chinese Medicine (TCM) has been constantly seeking suitable methods to help individuals achieve a balance and vitality of vital energy (qi and spirit), pursuing health and longevity. Chinese herbal medicine has the significant advantages of comprehensive conditioning, lack of toxic side effects, and the ability to provide long-term conditioning. Therefore, developing TCM formulas that can enhance vital energy is of great importance. Summary of the Invention
[0005] Based on this, the present invention provides a drug for enhancing vitality and spirit, and a method for preparing the same.
[0006] To achieve the above objectives, the present invention provides an application of a drug in the preparation of a product for enhancing vitality and spirit, the drug being prepared from the following raw materials in parts by weight: ginseng 1-10 parts, astragalus 6-35 parts, wolfberry 6-35 parts, privet fruit 15-50 parts, rosehip 15-50 parts, dodder seed 6-35 parts, polygonatum 15-50 parts, white peony root 6-35 parts, licorice 1-8 parts, malt 6-24 parts, and epimedium 12-60 parts.
[0007] In one embodiment, the improvement in energy and vitality includes gaining weight, increasing exercise endurance and physical strength, and repairing mitochondrial damage.
[0008] In one embodiment, the repair of mitochondrial damage includes reducing mitochondrial cristae structure disruption and mitochondrial swelling.
[0009] In one embodiment, the drug is prepared by the following method: the raw material is boiled in water for 1 to 2 hours, concentrated to a relative density of 1.06 to 1.15 at a temperature of 50 to 80 degrees Celsius, and then precipitated with alcohol and the alcohol is recovered to obtain the drug.
[0010] In one embodiment, the product includes pharmaceuticals and health foods.
[0011] In one embodiment, the drug is an oral medication.
[0012] In one embodiment, the dosage form of the drug is an oral liquid, granules, or tablets.
[0013] In one embodiment, the pharmaceutical product further includes pharmaceutically acceptable excipients.
[0014] In one embodiment, the excipients are selected from one or more of solvents, propellants, emulsifiers, colorants, binders, disintegrants, fillers, lubricants, wetting agents, stabilizers, flavoring agents, preservatives, fragrances, penetration enhancers, pH adjusters, and plasticizers.
[0015] The above-described solution of the present invention has the following beneficial effects:
[0016] Based on existing traditional Chinese medicine formulas, the researchers of this invention conducted extensive experimental studies and developed a new application for these formulas in enhancing vitality and spirit. Through experimental research, the inventors discovered that the aforementioned medicine, by repairing mitochondrial structure, reducing cristae damage and mitochondrial swelling, has a protective effect against mitochondrial damage. This effectively improves the decline in exercise endurance and physical strength caused by insufficient vitality and spirit, promotes weight gain and bodily recovery, and has a certain effect on enhancing vitality and spirit. This invention provides a new application for the aforementioned medicine, expands its application scope, and offers a new approach to enhancing vitality and spirit. Attached Figure Description
[0017] Figure 1 These are electron micrographs of mitochondria in the lung tissue of mice in each group of embodiments of the present invention. Detailed Implementation
[0018] To make the technical problems, solutions, and advantages of this invention clearer, a detailed description will be provided below with reference to the accompanying drawings and specific embodiments. Obviously, the described embodiments are only some, not all, of the embodiments of this invention. All other embodiments obtained by those skilled in the art based on the embodiments of this invention without creative effort are within the scope of protection of this invention.
[0019] Furthermore, the technical features involved in the different embodiments of the present invention described below can be combined with each other as long as they do not conflict with each other. Unless otherwise specified, the reagents and instruments used in the embodiments are conventional choices in the art. Experimental methods not specifying specific conditions in the embodiments are implemented according to conventional conditions, such as those described in literature, books, or methods recommended by the manufacturer.
[0020] Example
[0021] I. Experimental Materials
[0022] 1.1 Drugs
[0023] It was prepared using the following raw materials and methods:
[0024] Ingredients: 1-10 parts ginseng, 6-35 parts astragalus, 6-35 parts wolfberry, 15-50 parts privet fruit, 15-50 parts rosehip, 6-35 parts dodder seed, 15-50 parts polygonatum, 6-35 parts white peony root, 1-8 parts licorice root, 6-24 parts malt, and 12-60 parts epimedium.
[0025] (1) The above 11 medicinal materials are boiled in water for 1 to 2 hours.
[0026] (2) Vacuum low-temperature concentration: temperature 50-80 degrees Celsius, concentration to a relative density of 1.06-1.15.
[0027] (3) Alcohol precipitation and alcohol recovery.
[0028] (4) Add honey, sterilize and refrigerate.
[0029] (5) Filter until the liquid is clear, centrifuge until there is no precipitate, fill into bottles, and make into oral liquid.
[0030] 1.2 Reagents
[0031] Sodium pentobarbital, sodium chloride solution, electron microscopy fixative.
[0032] 1.3 Animals
[0033] 150 male middle-aged and elderly mice, aged 14 to 18 months (equivalent to 47 to 56 years old in human years), weighing 30 to 38g, were housed under the following conditions: a 12:12h light-dark cycle (lights on at 06:00), a temperature of 25±2℃, and a humidity of 50±10%, with free access to food and water.
[0034] II. Experimental Grouping
[0035] 2.1 Animal grouping and administration
[0036] Mice in the normal group had normal food and water intake, smooth and glossy fur, and no abnormal physical characteristics. Mice with insufficient energy and spirit showed reduced activity, lethargy, and disheveled, dull fur.
[0037] Mice in the normal control group were used as the normal control group. Mice with poor energy and spirit were randomly divided into an experimental group and high, medium, and low dose groups of the above-mentioned drugs, with 30 mice in each group. After grouping, the above-mentioned drugs were administered by gavage for 7 consecutive days. The specific dosage is shown in Table 1.
[0038] Table 1 Animal grouping and drug intervention
[0039] Grouping Drug intervention normal group An equal volume of 0.9% sodium chloride solution was administered via gavage. experimental group An equal volume of 0.9% sodium chloride solution was administered via gavage. High-dose group 0.40 ml / animal / day of the above medication administered by gavage. medium dose group 0.20 ml / animal / day of the above medication administered by gavage. low-dose group 0.10 ml / animal / day of the above medication administered by gavage.
[0040] III. Experimental Procedure
[0041] 3.1 Changes in mouse body weight
[0042] Starting from day 1, the daily weight of all mice was recorded, and the daily weight change percentage and maximum weight change were calculated by comparing the weight on day 1.
[0043] The results of mouse weight changes are shown in Table 2. As can be seen from the table, the high-dose and medium-dose groups of the above-mentioned drugs showed the fastest overall weight gain. In terms of the maximum weight gain compared to day 7, the high-dose and medium-dose groups showed the greatest weight gain, which was significantly different from the experimental group (p < 0.05). This indicates that the above-mentioned drugs can significantly increase the weight of mice with insufficient energy and improve their overall energy and spirit, and that the high-dose group is the most effective.
[0044] Table 2 Daily body weight change in mice (g)
[0045]
[0046] 3.2 Test of swimming time under load and exhaustion in mice
[0047] Each mouse was placed in an opaque cylindrical bucket at a water temperature of 29±2℃ and forced to swim under weight (a lead wire weighing 10% of the mouse's body weight was wrapped around the base of the mouse's tail). The exercise was continued until exhaustion (the mouse's nose was submerged for 3–5 seconds, or limb movements became uncoordinated). The time was recorded. One mouse was placed in each bucket. All groups of mice underwent exhaustive swimming training, and the time was recorded. Results were recorded in minutes (min).
[0048] Table 3 shows that the swimming time in all three drug groups was longer than that in the experimental group, with statistically significant increases in time observed in the high-dose and medium-dose groups (p < 0.05). This indicates that mice with insufficient energy and vitality exhibited decreased exercise endurance and physical strength, but the swimming time in all three drug groups was increased compared to the experimental group. Therefore, the aforementioned drugs can significantly improve the exercise endurance and physical strength of mice with insufficient energy and vitality, and enhance their overall energy and vitality, with the high dose being the optimal treatment.
[0049] Table 3 Comparison of swimming time for mice under load and exhaustion (min) )
[0050]
[0051] 3.3 Electron microscopy examination of mitochondrial status in mouse lung tissue
[0052] After the experiment, mice in each group were anesthetized by intraperitoneal injection of 10% sodium pentobarbital. After adequate anesthesia, the mice were euthanized by cervical dislocation, and fresh lung tissue was removed and placed in electron microscopy fixative. The tissue was then cut into 1-2 mm pieces with a blade, dehydrated, embedded, and sectioned. The lung tissue sections were observed, and the morphology and structural characteristics of mitochondria were recorded using an electron microscope image acquisition system.
[0053] Electron microscopy examination of mitochondrial status in mouse lung tissue, such as Figure 1 As shown, in the normal group, the mitochondrial cristae structure was clear and intact, the mitochondria were normal in morphology and structure, some mitochondria were fused, and the basement membrane was clear and without breakage. In the experimental group, the cell nucleus was enlarged in compensation, there were fewer mitochondria, edema and cristae breakage were visible, and lysosomes, autophagosomes and a large number of vacuoles were visible. In the high-dose group of the above drugs, normal mitochondria were visible, with clear structure and intact morphology, some mitochondria were edematous, normal in size, and a small number of lysosomes were visible, and the overall condition was significantly improved compared with the experimental group. In the medium-dose group of the above drugs, mitochondrial swelling was visible, some matrix electron density was increased, and a small number of lysosomes and autophagosomes were visible. In the low-dose group of the above drugs, mitochondrial swelling was visible, matrix electron density was increased, and mitophagy, autophagosomes and lysosomes were visible. This indicates that the above drugs have a repairing effect on mitochondrial damage in the experimental group mice, can reduce cristae structure destruction and mitochondrial swelling, and restore the mitochondrial structure to a relatively clear and intact morphology.
[0054] In summary, the above-mentioned drugs can significantly increase body weight, improve emaciation caused by insufficient energy and spirit, and enhance energy and spirit; the above-mentioned drugs can significantly improve exercise endurance and physical strength, improve fatigue caused by insufficient energy and spirit, and enhance energy and spirit; moreover, the above-mentioned drugs also have a repairing effect on mitochondrial damage, can reduce cristae structure damage and mitochondrial swelling, and restore the mitochondrial structure to a relatively clear and intact shape.
[0055] The above description represents the preferred embodiments of the present invention. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.
Claims
1. The use of a drug in the preparation of a product for enhancing energy and vitality, characterized in that, The medicine is prepared from the following raw materials in parts by weight: ginseng 1-10 parts, astragalus 6-35 parts, wolfberry 6-35 parts, privet fruit 15-50 parts, rosehip 15-50 parts, dodder seed 6-35 parts, polygonatum 15-50 parts, white peony root 6-35 parts, licorice 1-8 parts, malt 6-24 parts, and epimedium 12-60 parts.
2. The application according to claim 1, characterized in that, The improvement of energy and spirit includes gaining weight, increasing exercise endurance and physical strength, and repairing mitochondrial damage.
3. The application according to claim 2, characterized in that, The repair of mitochondrial damage includes reducing mitochondrial cristae structure disruption and mitochondrial swelling.
4. The application according to claim 1, characterized in that, The drug is prepared by the following method: the raw material is boiled in water for 1 to 2 hours, concentrated to a relative density of 1.06 to 1.15 at a temperature of 50 to 80 degrees Celsius, precipitated with alcohol, and the alcohol is recovered to obtain the drug.
5. The application according to any one of claims 1 to 4, characterized in that, The products include pharmaceuticals and health foods.
6. The application according to claim 5, characterized in that, The medicine in question is an oral medication.
7. The application according to claim 5, characterized in that, The dosage form of the medicine is oral liquid, granules or tablets.
8. The application according to claim 5, characterized in that, The medicine also includes pharmaceutically acceptable excipients.
9. The application according to claim 8, characterized in that, The excipients are selected from one or more of the following: solvents, propellants, emulsifiers, colorants, binders, disintegrants, fillers, lubricants, wetting agents, stabilizers, flavoring agents, preservatives, fragrances, penetration enhancers, pH adjusters, and plasticizers.