Preparation method of antibacterial epoxy resin coating
By combining waterborne self-crosslinking modified epoxy resin and modified antibacterial agent, the problems of inconvenient construction and limited functionality of waterborne epoxy resin coatings are solved, and the mechanical strength, antibacterial properties and corrosion resistance of the coatings are improved to meet the usage requirements under specific conditions.
Patent Information
- Application Number
- CN202511482485.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-08
- Publication Date
- 2026-02-03
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Existing waterborne epoxy resin coatings suffer from problems such as inconvenient construction, energy consumption during heating and curing, inconvenient storage, and limited functionality, failing to meet the usage requirements under specific conditions.
A water-based self-crosslinking modified epoxy resin is used. By esterifying 5-phenylpent-2,4-dienoic acid with the hydroxyl groups on the side chain of the epoxy resin, unsaturated double bonds and phenyl groups are introduced to form a three-dimensional network structure. Modified antibacterial agents S-adenosyl-L-homocysteine, silver nitrate, and chloropropyltrichlorosilane are added to form a silver ion network structure and silane groups, which enhance mechanical strength, antibacterial properties, and corrosion resistance.
It improves the hardness, heat resistance, antibacterial properties and corrosion resistance of the coating, achieves high adhesion and anti-peeling effects, and significantly enhances the overall performance of the coating.
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Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the field of paint technology, in particular to a preparation method of antibacterial epoxy resin paint. BACKGROUND
[0002] Epoxy resin is widely used in the bonding of various metals and non-metallic materials, corrosion-resistant coatings, electrical insulation materials, composite materials and other fields due to its excellent adhesion, corrosion resistance, stability, insulation and mechanical strength. Most commonly used epoxy resins are viscous liquids or solids, insoluble in water and only soluble in organic solvents. Most organic solvents are volatile, toxic, flammable and explosive, so the application of epoxy resin is limited to a certain extent. Water-based epoxy resin not only protects the environment, but also reduces the cost of epoxy resin, so the research on water-based epoxy resin is increasingly valued.
[0003] However, the research on water-based epoxy resin in China started late, and the main research and development is a two-component water-based epoxy resin system, which needs to be used with a curing agent. The product prepared has the disadvantages of inconvenient construction, energy consumption of heating curing, inconvenient storage, etc. At the same time, the functions of the self-crosslinking water-based epoxy resin paint currently developed and published are relatively single, which cannot meet the use requirements under specific conditions. SUMMARY
[0004] The purpose of the present application is to provide a preparation method of antibacterial epoxy resin paint to solve the problems in the prior art.
[0005] In order to solve the above technical problems, the present application provides the following technical scheme: an antibacterial epoxy resin paint, the antibacterial epoxy resin paint mainly comprises, by weight fraction, 44-56 parts of water-based self-crosslinking modified epoxy resin, 0.2-0.4 parts of defoaming agent, 0.5-0.9 parts of leveling agent, 2-6 parts of filler, 0.3-0.5 parts of NX-8502 curing agent, 58-74 parts of deionized water, and 30-40 parts of ethanol.
[0006] Further, the water-based self-crosslinking modified epoxy resin is prepared from 5-phenylpent-2,4-dienoic acid, epoxy resin, dimethyl diallyl ammonium chloride, 2-acrylamide phenyl boronic acid and modified antibacterial agent.
[0007] Further, the modified antibacterial agent is prepared from S-adenosyl-L-homocysteine, silver nitrate and chloropropyltrichlorosilane.
[0008] Further, a preparation method of antibacterial epoxy resin paint comprises the following preparation steps: (1) 15-25 parts of epoxy resin is dissolved in 50-80 parts of toluene under nitrogen atmosphere, and then 10-16 parts of 5-phenylpent-2,4-dienoic acid is added after stirring, and the temperature is raised to 80-90°C, 2-4 parts of 10 wt% dibutyltin dilaurate toluene solution is added dropwise, and the temperature is continuously raised to 100-110°C, and the reaction is carried out for 2-4 hours under stirring at 80 rpm, and then concentrated for 1-3 hours under vacuum degree of -0.08 MPa and at 40°C, to obtain an esterified epoxy resin; (2) 10-20 parts of the esterified epoxy resin and 50-100 parts of ethylene glycol butyl ether are mixed under nitrogen atmosphere, and then the temperature is raised to 90-100°C, 2-4 parts of the mixed reaction solution is added dropwise at a rate of 0.5 drops / s, and the reaction is carried out for 5-7 hours under stirring at 100 rpm, 5-15 parts of N,N-dimethylethanolamine is added and stirred for 20-40 minutes, and then 10-30 parts of deionized water is added and emulsified at high speed of 1000 rpm for 30-50 minutes, to obtain a water-based self-crosslinking modified epoxy resin; (3) 44-56 parts of the water-based self-crosslinking modified epoxy resin, 0.2-0.4 parts of a defoaming agent, 0.5-0.9 parts of a leveling agent, 2-6 parts of a filler, 0.3-0.5 parts of NX-8502 curing agent, 58-74 parts of deionized water, and 30-40 parts of ethanol are mixed, to obtain an antibacterial epoxy resin coating.
[0009] Further, the epoxy resin in step (1) is any one of BFE-170, NPEF-170, and DER-354.
[0010] Further, the preparation step of the mixed reaction solution in step (2) is that 3-4 parts of dimethyl diallyl ammonium chloride, 4-6 parts of 2-acrylamide phenyl boronic acid, and 5-7 parts of a modified antibacterial agent are mixed in 40-60 parts of ethylene glycol butyl ether, to obtain the mixed reaction solution.
[0011] Further, the preparation step of the modified antibacterial agent is that 2-8 parts of silver nitrate and 5-15 parts of S-adenosyl-L-homocysteine are dissolved in 98-296 parts of deionized water, and the pH is adjusted to 6-7 with 0.5 mol / L sodium hydroxide aqueous solution, and then the temperature is raised to 70-90°C, and stirred at 120 rpm for 1-2 hours, and then the filtrate is obtained by filtration, and then the filtrate is left to stand at 20-30°C for 36-60 hours, and then the solid is obtained by filtration, and then the solid is dried in an oven at 50-60°C for 4-8 hours, and then 45-65 parts of dichloromethane is added and stirred, and then the temperature is lowered to -5-5°C, and then 9-18 parts of vinyltrichlorosilane and 10-20 parts of triethylamine are added, and then the reaction is carried out for 8-16 hours under stirring at 100 rpm, and then the solid is obtained by filtration, and then the solid is washed with dichloromethane for 3 times, and then the solid is dried in an oven at 25-35°C for 4-8 hours, to obtain the modified antibacterial agent.
[0012] Further, the defoaming agent in step (3) is any one of SPE-810, SPE-1000, and VES-100.
[0013] Further, the leveling agent in step (3) is any one of BYK-354, BYK-310, and Tech-100.
[0014] Further, the filler in step (3) is one or more of a mixture of silicon dioxide, kaolin, calcium carbonate, barium sulfate, aluminum hydroxide, and carbon nanotubes.
[0015] Compared with the prior art, the present application has the following beneficial effects: The carboxyl group in the 5-phenylpent-2,4-dienoic acid is esterified with the hydroxyl group in the side chain of the epoxy resin, a plurality of unsaturated double bonds are introduced, and a binding site is provided for subsequent reactions, and a phenyl group is introduced, which has a high steric hindering effect, so that the distance between the molecular chains of the epoxy resin is reduced, thereby increasing the intermolecular force and further improving the hardness of the coating after curing, and the heat resistance of the coating is also improved; then, the unsaturated double bonds in the dimethyl diallyl ammonium chloride, 2-acrylamide phenyl boronic acid, and modified antibacterial agent are added to form a three-dimensional network structure, which significantly enhances the mechanical strength of the coating; the cation contained in the dimethyl diallyl ammonium chloride can destroy bacterial growth to achieve antibacterial effect, and can form a firm connection with the surface of the object, thereby realizing high adhesion and anti-peeling effect; on this basis, the amide group contained in the 2-acrylamide phenyl boronic acid has good hydrophilicity and can form hydrogen bonds with other functional groups, thereby improving the durability of the coating, and the phenyl boronic acid structure can form a dense protective film on the surface of the object, effectively isolating the object from the external environment, preventing oxidation and corrosion of the surface of the object, and realizing corrosion resistance effect.
[0016] The modified antibacterial agent is prepared from S-adenosyl-L-homocysteine, silver nitrate, and chloropropyltrichlorosilane; the carboxyl group in the S-adenosyl-L-homocysteine is coordinated with silver nitrate to form a network structure with silver as the central ion, thereby achieving slow-release of silver ions, significantly improving the overall thermal stability and antibacterial performance, and introducing sulfur elements that can react with enzymes in the bacterial body to damage the cell wall of the bacteria, so that the bacteria lose their survival ability and achieve antibacterial effect; then, the amino group is combined with the chlorine group of vinyltrichlorosilane to introduce silane groups, which significantly enhance the mechanical strength and water resistance of the coating after curing, isolate corrosive liquids from entering the coating, and indirectly improve the corrosion resistance effect. DETAILED DESCRIPTION
[0017] The technical solutions in the embodiments of the present application will be clearly and completely described below with the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments of the present application, all other embodiments obtained by those skilled in the art without creative work fall within the protection scope of the present application.
[0018] In order to more clearly illustrate the method provided by the present application, the following embodiments are described in detail. In the following examples, the test methods of various indexes of the antibacterial epoxy resin coating prepared are as follows: Impact strength: the same mass of the examples and the comparative examples was coated on a tinplate with a size of 155 mm x 70 mm x 0.2 mm, cured at 60 DEG C for 8 h, and then cooled. The impact strength was tested according to GB / T1732-2020.
[0019] Salt spray resistance: the same mass of the examples and the comparative examples was coated on a tinplate with a size of 155 mm x 70 mm x 0.2 mm, cured at 60 DEG C for 8 h, and then cooled. The salt spray resistance was tested according to GB / T1771-2007.
[0020] Adhesion: the same mass of the examples and the comparative examples was coated on a tinplate with a size of 155 mm x 70 mm x 0.2 mm, cured at 60 DEG C for 8 h, and then cooled. The adhesion was tested by using adhesive tape to adhere and then tear off the coating, and observing the peeling of the coating.
[0021] Bacteriostatic rate: the same mass of the examples and the comparative examples was tested for the bacteriostatic rate of the coating according to GB / T 21866-2008.
[0022] Example 1 (1) 15 parts of BFE-170 epoxy resin was dissolved in 50 parts of toluene under a nitrogen atmosphere, and then 10 parts of 5-phenylpent-2,4-dienoic acid was added. The temperature was raised to 80 DEG C, and 2 parts of 10 wt% dibutyltin dilaurate toluene solution was added dropwise. The temperature was continuously raised to 100 DEG C, and the reaction was carried out at 80 rpm for 2 h. The vacuum degree was -0.08 MPa, and the concentration was carried out at 40 DEG C for 1 h to prepare an esterified epoxy resin; (2) 2 parts of silver nitrate and 5 parts of S-adenosyl-L-homocysteine were dissolved in 98 parts of deionized water, and the pH was adjusted to 6 with 0.5 mol / L sodium hydroxide aqueous solution. The temperature was raised to 70 DEG C, and the stirring was carried out at 120 rpm for 1 h. The filtrate was obtained by filtration, and was left to stand at 20 DEG C for 36 h. The solid was obtained by filtration, and was dried in an oven at 50 DEG C for 4 h. 45 parts of dichloromethane was added and stirred uniformly, and the temperature was lowered to -5 DEG C. Then, 9 parts of vinyltrichlorosilane and 10 parts of triethylamine were added. The reaction was carried out at 100 rpm for 8 h. The solid was obtained by filtration, and was washed with dichloromethane for 3 times. The solid was dried in an oven at 25 DEG C for 4 h to prepare a modified antibacterial agent. (3) Mix 3 parts of dimethyl diallyl ammonium chloride, 4 parts of 2-acrylamide phenylboronic acid, 5 parts of modified antibacterial agent and 40 parts of ethylene glycol butyl ether evenly to prepare a mixed reaction solution; (4) Under a nitrogen atmosphere, 10 parts of esterified epoxy resin and 50 parts of ethylene glycol butyl ether were mixed evenly, heated to 90°C, and 2 parts of the mixed reaction solution were added dropwise at a rate of 0.5 drops / s. The mixture was stirred at 100 rpm for 5 h, and 5 parts of N,N-dimethylethanolamine were added and stirred for 20 min. Then, 10 parts of deionized water were added and emulsified at 1000 rpm for 30 min to obtain waterborne self-crosslinking modified epoxy resin. (5) Mix 44 parts of waterborne self-crosslinking modified epoxy resin, 0.2 parts of SPE-810 defoamer, 0.5 parts of BYK-354 leveling agent, 2 parts of kaolin, 0.3 parts of NX-8502 curing agent, 58 parts of deionized water and 30 parts of ethanol evenly to prepare antibacterial epoxy resin coating.
[0023] Example 2 (1) Under a nitrogen atmosphere, 20 parts of NPEF-170 epoxy resin were dissolved in 65 parts of toluene. After stirring evenly, 13 parts of 5-phenylpentan-2,4-dienoic acid were added. The temperature was raised to 85°C, and 3 parts of 10wt% dibutyltin dilaurate toluene solution were added dropwise. The temperature was raised to 105°C and reacted for 3 hours under stirring at 80 rpm. The mixture was then concentrated at a vacuum of -0.08 MPa and 40°C for 2 hours to obtain esterified epoxy resin. (2) Dissolve 5 parts silver nitrate and 10 parts S-adenosyl-L-homocysteine in 197 parts deionized water, adjust the pH to 6.5 with 0.5 mol / L sodium hydroxide aqueous solution, heat to 80℃, stir at 120 rpm for 1.5 h, filter and collect the filtrate, let stand at 25℃ for 48 h, filter and collect the solid, dry in an oven at 55℃ for 6 h, add 55 parts dichloromethane and stir evenly, cool to 0℃, then add 13.5 parts vinyltrichlorosilane and 15 parts triethylamine, react at 100 rpm for 12 h, filter and collect the solid, wash 3 times with dichloromethane, dry in an oven at 30℃ for 6 h to obtain the modified antibacterial agent; (3) Mix 3.5 parts of dimethyl diallyl ammonium chloride, 5 parts of 2-acrylamide phenylboronic acid, 6 parts of modified antibacterial agent, and 50 parts of ethylene glycol butyl ether evenly to prepare a mixed reaction solution; (4) Under a nitrogen atmosphere, 15 parts of esterified epoxy resin and 75 parts of ethylene glycol butyl ether were mixed evenly, heated to 95°C, and 3 parts of the mixed reaction solution were added dropwise at a rate of 0.5 drops / s. The mixture was stirred at 100 rpm for 6 hours, 10 parts of N,N-dimethylethanolamine were added and stirring was continued for 30 minutes. Then, 20 parts of deionized water were added and emulsified at 1000 rpm for 40 minutes to obtain waterborne self-crosslinking modified epoxy resin. (5) Mix 50 parts of water-based self-crosslinking modified epoxy resin, 0.3 parts of SPE-1000 defoamer, 0.7 parts of BYK-310 leveling agent, 4 parts of calcium carbonate, 0.4 parts of NX-8502 curing agent, 66 parts of deionized water and 35 parts of ethanol evenly to prepare antibacterial epoxy resin coating.
[0024] Example 3 (1) Under a nitrogen atmosphere, 25 parts of DER-354 epoxy resin were dissolved in 80 parts of toluene, stirred evenly, and then 16 parts of 5-phenylpentan-2,4-dienoic acid were added. The temperature was raised to 90°C, and 4 parts of 10wt% dibutyltin dilaurate toluene solution were added dropwise. The temperature was further raised to 110°C, and the reaction was carried out at 80 rpm for 4 h. The mixture was then concentrated at a vacuum of -0.08 MPa and 40°C for 3 h to obtain esterified epoxy resin. (2) Dissolve 8 parts silver nitrate and 15 parts S-adenosyl-L-homocysteine in 296 parts deionized water, adjust the pH to 7 with 0.5 mol / L sodium hydroxide aqueous solution, heat to 90℃, stir at 120 rpm for 2 h, filter and collect the filtrate, let stand at 30℃ for 60 h, filter and collect the solid, dry in an oven at 60℃ for 8 h, add 65 parts dichloromethane and stir evenly, cool to 5℃, then add 18 parts vinyltrichlorosilane and 20 parts triethylamine, react at 100 rpm for 16 h, filter and collect the solid, wash with dichloromethane 3 times, dry in an oven at 35℃ for 8 h to obtain the modified antibacterial agent; (3) Mix 4 parts of dimethyl diallyl ammonium chloride, 6 parts of 2-acrylamide phenylboronic acid, 7 parts of modified antibacterial agent and 60 parts of ethylene glycol butyl ether evenly to prepare a mixed reaction solution; (4) Under a nitrogen atmosphere, 20 parts of esterified epoxy resin and 100 parts of ethylene glycol butyl ether were mixed evenly, heated to 100°C, and 4 parts of the mixed reaction solution were added dropwise at a rate of 0.5 drops / s. The mixture was stirred at 100 rpm for 7 h, and 15 parts of N,N-dimethylethanolamine were added and stirred for 40 min. Then, 30 parts of deionized water were added and emulsified at 1000 rpm for 50 min to obtain waterborne self-crosslinking modified epoxy resin. (5) Mix 56 parts of waterborne self-crosslinking modified epoxy resin, 0.4 parts of VES-100 defoamer, 0.9 parts of Tech-100 leveling agent, 6 parts of carbon nanotubes, 0.5 parts of NX-8502 curing agent, 74 parts of deionized water and 40 parts of ethanol evenly to prepare antibacterial epoxy resin coating.
[0025] Comparative Example 1 The difference between Comparative Example 1 and Example 2 is that step (1) is omitted, and step (4) is changed to: under a nitrogen atmosphere, 15 parts of NPEF-170 epoxy resin and 75 parts of ethylene glycol butyl ether are mixed evenly, heated to 95°C, and 3 parts of the mixed reaction solution are added dropwise at a rate of 0.5 drops / s. The mixture is stirred at 100 rpm for 6 hours, 10 parts of N,N-dimethylethanolamine are added and stirring is continued for 30 minutes, and then 20 parts of deionized water are added and emulsified at 1000 rpm for 40 minutes to obtain waterborne self-crosslinking modified epoxy resin. The remaining steps are the same as in Example 2.
[0026] Comparative Example 2 The difference between Comparative Example 2 and Example 2 lies in step (2). Step (2) is changed to: stirring 10 parts of S-adenosyl-L-homocysteine and 55 parts of dichloromethane until homogeneous, cooling to 0°C, then adding 13.5 parts of vinyltrichlorosilane and 15 parts of triethylamine, reacting at 100 rpm for 12 h, filtering to obtain the solid, washing three times with dichloromethane, and drying in a 30°C oven for 6 h to obtain the modified antibacterial agent. The remaining steps are the same as in Example 2.
[0027] Comparative Example 3 The difference between Comparative Example 3 and Example 2 lies in step (2). Step (2) is changed to: dispersing 5 parts of silver nitrate in 55 parts of dichloromethane, cooling to 0°C, then adding 13.5 parts of vinyltrichlorosilane and 15 parts of triethylamine, reacting at 100 rpm for 12 h, filtering to obtain the solid, washing 3 times with dichloromethane, and drying in an oven at 30°C for 6 h to obtain the modified antibacterial agent. The remaining steps are the same as in Example 2.
[0028] Comparative Example 4 The difference between Comparative Example 4 and Example 2 lies in step (2). Step (2) is changed to: dissolving 5 parts silver nitrate and 10 parts S-adenosyl-L-homocysteine in 197 parts deionized water, adjusting the pH to 6.5 with 0.5 mol / L sodium hydroxide aqueous solution, heating to 80°C, stirring at 120 rpm for 1.5 h, filtering and collecting the filtrate, letting it stand at 25°C for 48 h, filtering and collecting the solid, and drying it in an oven at 55°C for 6 h to obtain the modified antibacterial agent. The remaining steps are the same as in Example 2.
[0029] Comparative Example 5 The difference between Comparative Example 5 and Example 2 lies in step (3). Step (3) is changed to: mixing 5 parts of 2-acrylamide phenylboronic acid, 6 parts of modified antibacterial agent, and 50 parts of ethylene glycol butyl ether evenly to obtain a mixed reaction solution. The remaining steps are the same as in Example 2.
[0030] Comparative Example 6 The difference between Comparative Example 6 and Example 2 lies in step (3). Step (3) is changed to: mixing 3.5 parts of dimethyl diallyl ammonium chloride, 6 parts of modified antibacterial agent, and 50 parts of ethylene glycol butyl ether evenly to obtain a mixed reaction solution. The remaining steps are the same as in Example 2.
[0031] Example of effect Table 1 below shows the performance analysis results of the antibacterial epoxy resin coatings of Examples 1 to 3 and Comparative Examples 1 to 6 of the present invention.
[0032] Table 1 A comparison of the experimental data from Examples 1, 2, and 3 with Comparative Example 1 reveals that the esterification of the carboxyl group in 5-phenylpentan-2,4-dienoic acid with the hydroxyl group in the epoxy resin side chain introduces multiple unsaturated double bonds, providing binding sites for subsequent reactions. Simultaneously, the introduction of phenyl groups provides a high steric hindrance effect, reducing the distance between epoxy resin molecular chains, increasing intermolecular forces, improving the hardness of the cured coating, and enhancing its heat resistance. A comparison of the experimental data from Examples 1, 2, and 3 with Comparative Example 2 reveals that the coordination reaction using silver nitrate achieves a slow-release effect of silver ions, resulting in antibacterial properties. A comparison of the experimental data from Examples 1, 2, and 3 with Comparative Example 3 reveals that the formation of a network structure with silver as the central ion using S-adenosine-L-homocysteine achieves a slow-release effect of silver ions, significantly improving overall thermal stability and antibacterial properties. Furthermore, the introduction of sulfur allows it to react with enzymes within bacteria, disrupting the bacterial cell wall and causing bacterial death. The coating loses its ability to survive, thus achieving an antibacterial effect. A comparison of experimental data from Examples 1, 2, and 3 with Comparative Example 4 reveals that by combining with vinyltrichlorosilane and introducing silane groups, the mechanical strength and water resistance of the coating are significantly enhanced after curing, preventing corrosive liquids from entering the coating and indirectly improving corrosion resistance. A comparison of experimental data from Examples 1, 2, and 3 with Comparative Example 5 reveals that the cations contained in dimethyl diallyl ammonium chloride can destroy bacterial growth, achieving an antibacterial effect, and can also form a strong bond with the object surface, thereby achieving high adhesion and anti-peeling effects. A comparison of experimental data from Examples 1, 2, and 3 with Comparative Example 6 reveals that the amide groups contained in 2-acrylamide phenylboronic acid have good hydrophilicity, easily forming hydrogen bonds with other functional groups, improving coating durability, and assisting the phenylboronic acid structure to form a dense protective film on the object surface, effectively isolating the object from contact with the external environment, preventing oxidation and corrosion of the object surface, and achieving corrosion resistance.
[0033] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No markings in the claims should be construed as limiting the scope of the claims.
Claims
1. A method for preparing an antibacterial epoxy resin coating, characterized in that, The preparation steps include the following: (1) Under a nitrogen atmosphere, 20 parts of NPEF-170 epoxy resin were dissolved in 65 parts of toluene. After stirring evenly, 13 parts of 5-phenylpentan-2,4-dienoic acid were added. The temperature was raised to 85°C, and 3 parts of 10wt% dibutyltin dilaurate toluene solution were added dropwise. The temperature was raised to 105°C and reacted for 3 hours under stirring at 80 rpm. The mixture was then concentrated at a vacuum of -0.08 MPa and 40°C for 2 hours to obtain esterified epoxy resin. (2) Dissolve 5 parts silver nitrate and 10 parts S-adenosyl-L-homocysteine in 197 parts deionized water, adjust the pH to 6.5 with 0.5 mol / L sodium hydroxide aqueous solution, heat to 80℃, stir at 120 rpm for 1.5 h, filter and collect the filtrate, let stand at 25℃ for 48 h, filter and collect the solid, dry in an oven at 55℃ for 6 h, add 55 parts dichloromethane and stir evenly, cool to 0℃, then add 13.5 parts vinyltrichlorosilane and 15 parts triethylamine, react at 100 rpm for 12 h, filter and collect the solid, wash 3 times with dichloromethane, dry in an oven at 30℃ for 6 h to obtain the modified antibacterial agent; (3) Mix 3.5 parts of dimethyl diallyl ammonium chloride, 5 parts of 2-acrylamide phenylboronic acid, 6 parts of modified antibacterial agent, and 50 parts of ethylene glycol butyl ether evenly to prepare a mixed reaction solution; (4) Under a nitrogen atmosphere, 15 parts of esterified epoxy resin and 75 parts of ethylene glycol butyl ether were mixed evenly, heated to 95°C, and 3 parts of the mixed reaction solution were added dropwise at a rate of 0.5 drops / s. The mixture was stirred at 100 rpm for 6 hours, 10 parts of N,N-dimethylethanolamine were added and stirring was continued for 30 minutes. Then, 20 parts of deionized water were added and emulsified at 1000 rpm for 40 minutes to obtain waterborne self-crosslinking modified epoxy resin. (5) Mix 50 parts of water-based self-crosslinking modified epoxy resin, 0.3 parts of SPE-1000 defoamer, 0.7 parts of BYK-310 leveling agent, 4 parts of calcium carbonate, 0.4 parts of NX-8502 curing agent, 66 parts of deionized water and 35 parts of ethanol evenly to prepare antibacterial epoxy resin coating.