An automated solid phase extraction instrument

Abstract

The application relates to the technical field of solid phase extraction, in particular to an automatic solid phase extraction instrument, which comprises an outer shell, a sample tube rack and a collection tube rack installed in the outer shell, a sample inlet needle connected to the upper part of the outer shell above the sample tube rack, a plunger rod, a fixed plate, an extraction column tray and a waste liquid collection frame connected to the upper part of the outer shell above the collection tube rack from top to bottom, an extraction column body installed in the extraction column tray, a splash-proof assembly installed in the waste liquid collection frame, and an auxiliary liquid discharge assembly installed on the bottom surface of the waste liquid collection frame. The automatic solid phase extraction instrument can absorb and collect the falling waste liquid through the sponge layer, avoids the waste liquid from splashing around under high-speed impact, and avoids the influence of the splashing of part of the waste liquid on the inner side wall of the waste liquid collection frame on the thoroughness of the later-stage discharge, so that the thoroughness of the waste liquid discharge of the solid phase extraction instrument is improved.

Description

Technical Field

[0001] This invention relates to the field of solid phase extraction technology, specifically to an automated solid phase extraction instrument. Background Technology

[0002] Automated solid-phase extraction instruments can automatically complete the entire solid-phase extraction process without human intervention, thus eliminating human error and ensuring the consistency of sample processing. This improves analytical efficiency and accuracy, and they are commonly used for sample pretreatment in fields such as environmental monitoring, pharmaceutical industry, and food safety.

[0003] For example, the prior art patent with publication number "CN111701280B" entitled "Automatic Solid Phase Extraction Device" discloses that firstly, the sealing plug does not contact the wall of the connecting hole. Then, the control box controls the solenoid valve on the second hose to open, and after a portion of the reagent solution in the reagent cylinder enters the receiving chamber, the control box controls the solenoid valve on the second hose to close, the cylinder extends, and pushes the sealing plug and piston downward, so that the reagent in the receiving chamber passes through the packing and is discharged from the outlet, realizing positive pressure column permeation of the activation step, creating a solvent environment, and reducing the recovery time of the analyte. Another example is the prior art patent with publication number "CN115645986B" entitled "Fully Automatic..." The "Dynamic Solid-Phase Extraction Instrument" discloses a sampling needle connected to an extraction plunger. The extraction plunger slides vertically within the housing and can be inserted into the lower extraction column after sliding down. The extraction plunger has a sealing ring on its circumference, which seals the column after insertion before injection. The extraction tray has four rows and six columns of mounting positions for twenty-four extraction columns. The extraction tray is driven by a stepper motor installed within the housing. The stepper motor drive is connected to gears, and a rack is installed on the extraction tray. The gears and racks work together to complete the transmission. The waste liquid discharge device includes a waste liquid collection tank located on the collection tray. The waste liquid collection tank has multiple independent collection slots, each connected to an independent waste liquid discharge pipeline.

[0004] In the aforementioned automated solid-phase extraction (SPE) instruments, when waste liquid needs to be collected, the waste liquid falls into multiple independent collection tanks within a waste liquid collection trough. When the waste liquid drips onto the bottom surface of the collection tank, due to the lack of elastic deformation and absorption capacity of the bottom surface, the waste liquid splashes in all directions under high-speed impact, causing some of the waste liquid to splash onto the inner wall of the collection tank, affecting the thoroughness of the subsequent discharge of the waste liquid. Therefore, this affects the waste liquid discharge operation of the SPE instrument. So, we propose an automated solid-phase extraction instrument to solve the problems mentioned above. Summary of the Invention

[0005] The purpose of this invention is to provide an automated solid-phase extraction instrument to solve the problem mentioned in the background art. In current automated solid-phase extraction instruments on the market, when waste liquid needs to be collected, the waste liquid falls into multiple independent collection tanks within a waste liquid collection tank. When the waste liquid drips onto the bottom surface of the collection tank, due to the lack of elastic deformation and absorption capacity of the bottom surface of the collection tank, the waste liquid splashes in all directions under high-speed impact, causing some of the waste liquid to splash onto the inner wall of the collection tank, affecting the thoroughness of the subsequent discharge of waste liquid, and thus affecting the waste liquid discharge operation of the solid-phase extraction instrument.

[0006] To achieve the above objectives, the present invention provides the following technical solution: an automated solid-phase extraction instrument, comprising an outer shell and a sample tube rack and a collection tube rack installed inside it, wherein an injection needle is connected to the outer shell above the sample tube rack, and a plunger rod, a fixing plate, an extraction column tray and a waste liquid collection frame are connected sequentially from top to bottom in the outer shell above the collection tube rack, wherein the extraction column body is installed inside the extraction column tray, an anti-splash component is installed inside the waste liquid collection frame, and an auxiliary drainage component is installed on the bottom surface of the waste liquid collection frame.

[0007] Preferably, a sample tube body is inserted into the sample tube rack, and a collection tube body is inserted into the collection tube rack. The bottom surfaces of the sample tube rack and the collection tube rack, as well as the side surfaces of the extraction column tray, are slidably connected to the inside of the outer shell via a track assembly.

[0008] Preferably, the outer side of the fixing plate is fixedly connected to the inner sidewall of the outer casing, and a plunger rod is slidably connected through the inside of the fixing plate.

[0009] Preferably, four movement control mechanisms located at different positions are installed inside the outer casing. The upper part of the injection needle and plunger rod, as well as the rear side of the sample tube rack and collection tube rack, are all connected to the interior of the outer casing through the movement control mechanisms located at corresponding positions to form an automatic sliding structure. The movement control mechanisms are electric push rods.

[0010] Preferably, the waste liquid collection frame is equipped with a leak tray with a mesh structure inside, and the anti-splash component includes a sponge layer symmetrically placed above the leak tray. A squeezing plate is symmetrically arranged above the middle of the leak tray, and one side of the squeezing plate is in contact with one side of the sponge layer, and the bottom surface of the squeezing plate is in contact with the upper surface of the leak tray.

[0011] Preferably, the right side of the outer casing has an accommodating groove and a sliding groove. A rotating rod is rotatably installed inside the accommodating groove, and a waste liquid collection frame is connected through the outer side of the rotating rod. The snap-fit ​​block on the inner side wall of the waste liquid collection frame engages and slides with the snap-fit ​​groove on the outer side of the rotating rod. A bidirectional screw is installed in the groove on the side of the waste liquid collection frame near the rotating rod, and a compression plate is threaded to the outer side of the bidirectional screw. A connecting rope is wound around the outer side of one end of the bidirectional screw, and the lower end of the connecting rope is connected to the interior of the outer casing through a guide wheel. A vortex spring is nested on the outer side of the other end of the bidirectional screw. A flow guide hose is installed through the bottom surface of the waste liquid collection frame, and the flow guide hose passes through an arc-shaped groove inside the outer casing and connects to the lower end of the rotating rod. The lower end of the rotating rod is hollow. The lower end of the rotating rod is connected to the upper end of the drain pipe through a sealed bearing, and the lower end of the "L"-shaped drain pipe passes through the right side of the outer casing.

[0012] Preferably, the auxiliary drainage component includes a protruding post installed on the bottom surface of the waste liquid collection frame.

[0013] Preferably, the slide groove is equipped with a protrusion, the protrusion is triangular and the slide groove is arc-shaped, the lower end of the protruding post is inserted into the slide groove, and the protruding post forms a lifting structure through the protrusion.

[0014] Preferably, the front side of the extraction column tray has a flow groove, and the bottom surface of the flow groove is connected to the outer frame through a through-installed connecting pipe. The outer frame is fitted on the lower outer side of the extraction column body, and the inside of the outer frame is hollow.

[0015] Preferably, the inner wall of the outer frame is provided with equal-spaced control cavities, and a piston assembly is connected to one end of the control cavity. The other end of the piston assembly is connected to an arc-shaped clamping block, and the inner wall of the clamping block is in contact with the outer surface of the extraction column body. The space inside the control cavity is connected to the space inside the outer frame.

[0016] Compared with the prior art, the beneficial effects of the present invention are: this automated solid-phase extraction instrument avoids some waste liquid splashing onto the inner wall of the waste liquid collection frame, which would affect the thoroughness of subsequent discharge, thus facilitating the improvement of the thoroughness of waste liquid discharge by the solid-phase extraction instrument. The specific details are as follows:

[0017] (1) By setting up a sponge layer, the falling waste liquid can be absorbed and collected, avoiding the waste liquid from splashing around under high-speed impact, and thus avoiding some waste liquid from splashing onto the inner wall of the waste liquid collection frame and affecting the thoroughness of the later discharge. Therefore, it is easy to improve the thoroughness of the solid phase extractor in discharging waste liquid.

[0018] Furthermore, when the waste liquid collection frame is rotated and stored in the receiving tank, pulling one end of the connecting rope causes the connecting rope to drive the bidirectional screw to rotate. This causes the bidirectional screw to drive the outer threaded extrusion plate to move outward and extrude the sponge layer, so that the waste liquid adsorbed in the sponge layer is extruded downward and flows out, making it easier for the waste liquid to be discharged.

[0019] At the same time, when the waste liquid collection frame is rotated and stored in the receiving tank, the protrusions contact multiple triangular protrusions in sequence, which causes the protrusions to drive the waste liquid collection frame to shake up and down, which can further reduce the liquid remaining in the sponge layer, thus further improving the thoroughness of waste liquid discharge.

[0020] (2) By injecting a certain amount of heating water or cooling water into the flow channel and the outer frame, the outer side of the extraction column body can be heated or cooled according to the usage requirements. Therefore, different temperature control requirements can be met in special scenarios to avoid the temperature affecting the extraction work and efficiency. The flow channel is set in a "well" shape.

[0021] Furthermore, when liquid is injected into the outer frame and the control chamber, the liquid pushes the piston assembly and clamping block to move, so that the clamping block can clamp the lower outer side of the extraction column body, further improving the stability of the extraction column body installation and preventing the extraction column body from falling off. At the same time, the piston assembly and clamping block, which are made of copper, can conduct heat, thus further improving the heating or cooling efficiency. Attached Figure Description

[0022] Figure 1 This is a three-dimensional structural diagram of the present invention;

[0023] Figure 2 This is a schematic diagram of the rear view structure of the present invention;

[0024] Figure 3 This is a schematic diagram of the three-dimensional structure of the collection tube rack of the present invention;

[0025] Figure 4 This is a schematic diagram of the rear view of the waste liquid collection frame and the outer shell of the present invention;

[0026] Figure 5 This is a partial bottom sectional view of the connection between the waste liquid collection frame and the outer shell of the present invention;

[0027] Figure 6 This is a schematic cross-sectional view of the waste liquid collection frame of the present invention;

[0028] Figure 7 This is a schematic diagram of the three-dimensional structure of the sponge layer of the present invention;

[0029] Figure 8 This is a schematic diagram of the separation structure between the sponge layer and the leakage tray of the present invention;

[0030] Figure 9 This is a top view of the chute structure of the present invention;

[0031] Figure 10 This is a schematic diagram of the top cross-sectional structure of the extraction column tray in Embodiment 2 of the present invention;

[0032] Figure 11 This is a bottom view of the extraction column tray structure in Embodiment 2 of the present invention;

[0033] Figure 12 This is a top view of the outer frame structure in Embodiment 3 of the present invention;

[0034] Figure 13 This is a schematic diagram of the main sectional view of the outer frame in Embodiment 3 of the present invention.

[0035] In the diagram: 1. Outer shell; 101. Receptacle; 102. Slide groove; 2. Sample tube rack; 3. Sample tube body; 4. Injection needle; 5. Collection tube rack; 6. Collection tube body; 7. Extraction column tray; 71. Flow groove; 8. Plunger rod; 9. Waste liquid collection frame; 10. Extraction column body; 11. Fixing plate; 12. Rotating rod; 13. Drain pipe; 14. Sponge layer; 15. Squeezing plate; 16. Leakage support plate; 17. Bidirectional lead screw; 171. Connecting rope; 172. Vortex spring; 18. Protruding column; 19. Protrusion; 20. Outer frame; 21. Connecting pipe; 22. Control chamber; 221. Piston assembly; 222. Clamping block; 23. Guide hose. Detailed Implementation

[0036] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0037] Please see Figures 1-13 The present invention provides the following technical solution:

[0038] Example 1: The automated solid-phase extraction instrument in this example avoids splashing of waste liquid during collection, thus improving the thoroughness of waste liquid collection and discharge. See attached diagram for the specific structure. Figures 1-9As shown, the device includes an outer shell 1 and a sample tube rack 2 and a collection tube rack 5 installed inside it. An injection needle 4 is connected inside the outer shell 1 above the sample tube rack 2. A plunger rod 8, a fixing plate 11, an extraction column tray 7, and a waste liquid collection frame 9 are connected sequentially from top to bottom inside the outer shell 1 above the collection tube rack 5. An extraction column body 10 is installed inside the extraction column tray 7. An anti-splash component is installed inside the waste liquid collection frame 9, and an auxiliary drainage component is installed on the bottom surface of the waste liquid collection frame 9. A sample tube body 3 is inserted into the sample tube rack 2, and a collection tube body 6 is inserted into the collection tube rack 5. The bottom surfaces of the sample tube rack 2 and the collection tube rack 5, as well as the side surface of the extraction column tray 7, are slidably connected to the inside of the outer shell 1 through a track assembly.

[0039] The outer side of the fixing plate 11 is fixedly connected to the inner side wall of the outer shell 1, and the plunger rod 8 is slidably connected through the inside of the fixing plate 11. Four moving control mechanisms located at different positions are installed inside the outer shell 1. The upper part of the injection needle 4 and the plunger rod 8, as well as the rear side of the sample tube rack 2 and the collection tube rack 5, are all connected to the inside of the outer shell 1 through the moving control mechanisms located at corresponding positions to form an automatic sliding structure. The moving control mechanism is an electric push rod. The inside of the waste liquid collection frame 9 is equipped with a leakage tray 16 with a mesh structure inside. The anti-splash assembly includes a sponge layer 14 symmetrically placed above the leakage tray 16. A squeezing plate 15 is symmetrically arranged above the middle of the leakage tray 16. One side of the squeezing plate 15 is in contact with one side of the sponge layer 14. The bottom surface of the squeezing plate 15 is in contact with the upper surface of the leakage tray 16. The right side of the outer shell 1 has a receiving groove 101 and a sliding groove 102. A rotating rod 12 is rotatably installed inside the receiving groove 101, and the outer side of the rotating rod 12 passes through the inner side of the receiving groove 101. A waste liquid collection frame 9 is connected, and the snap-fit ​​block on the inner side wall of the waste liquid collection frame 9 is engaged and slidably connected with the snap-fit ​​groove on the outer side of the rotating rod 12. A double-ended lead screw 17 is installed in the groove on the side of the waste liquid collection frame 9 closest to the rotating rod 12, and a compression plate 15 is threaded onto the outer side of the double-ended lead screw 17. A connecting rope 171 is wound around the outer side of one end of the double-ended lead screw 17, and the lower end of the connecting rope 171 is connected to the interior of the outer casing 1 via a guide wheel. The other end of the double-ended lead screw 17 is nested with... A spiral spring 172 is connected to the bottom surface of the waste liquid collection frame 9, and a guide hose 23 is installed through it. The guide hose 23 passes through an arc-shaped groove opened inside the outer shell 1 and is connected to the lower end of the rotating rod 12. The lower end of the rotating rod 12 is hollow. The lower end of the rotating rod 12 is connected to the upper end of the drain pipe 13 through a sealed bearing. The lower end of the drain pipe 13, which is L-shaped, passes through the right side of the outer shell 1. The auxiliary drain assembly includes a protrusion 18 installed on the bottom surface of the waste liquid collection frame 9.

[0040] The slide groove 102 is internally fitted with a protrusion 19, which is triangular in shape, while the slide groove 102 is arc-shaped. The lower end of the protruding post 18 is inserted into the slide groove 102, and the protruding post 18 forms a lifting structure through the protrusion 19. The injection needle 4, plunger rod 8, sample tube rack 2, and collection tube rack 5 are all slidably connected to the interior of the outer shell 1 through a movement control mechanism. The movement control mechanism is an electric push rod or a cylinder. When the entire automated solid phase extraction instrument is in use, the movement control mechanism inside the outer shell 1 drives a row of injection needles 4 to move downwards simultaneously, so that the injection needles 4 are inserted into the sample tube body 3 for sample injection. Then, the sample is injected through the outer shell. The high-precision injection pump inside the body 1 and the tubing inside the plunger rod 8 deliver the sample solution to be processed to the extraction column body 10 at a stable and settable flow rate. The target analyte is selectively retained on the adsorbent inside the extraction column body 10. Then, the eluent is injected into the extraction column body 10 to remove weak retention interference impurities retained on the extraction column body 10, while the target analyte is firmly adsorbed. Then, a strong elution solvent is used to desorb the target analyte from the adsorbent, causing the target analyte to drip into the collection tube body 6 below for collection. Since this part is prior art, it will not be described in detail here.

[0041] When waste liquid needs to be collected during the entire extraction process, the upper end of the rotating rod 12 can be rotated by the servo motor inside the outer casing 1. The rotating rod 12 is slidably connected to the locking block through the locking groove on the outside, causing the waste liquid collection frame 9 to rotate together. This causes the waste liquid collection frame 9 to rotate from the receiving groove 101 to directly below the extraction column body 10. At this time, the waste liquid collection frame 9 drives the bottom guide hose 23 to rotate together. The guide hose 23 rotates in the arc-shaped groove opened inside the outer casing 1, and then the extraction column body... The waste liquid generated within 10 drips onto the sponge layer 14 below. The sponge layer 14 absorbs and collects the falling waste liquid, preventing it from splashing outwards under high-speed impact. This also prevents some waste liquid from splashing onto the inner wall of the waste liquid collection frame 9, which would affect the thoroughness of subsequent discharge. Therefore, it facilitates the thoroughness of waste liquid discharge by the solid phase extractor. After the waste liquid collection is completed, the servo motor drives the rotating rod 12 to rotate in the opposite direction and reset, causing the rotating rod 12 to rotate the waste liquid collection frame 9 and store it in the receiving tank 101. At this time, the guide wheel and the guide limit at one end of the connecting rope 171 cause the waste liquid collection frame 9 to rotate and be stored in the receiving tank 101, pulling one end of the connecting rope 171. The connecting rope 171 drives the bidirectional screw 17 to rotate, and the spiral spring 172 stores force. The bidirectional screw 17 drives the two outer threaded extrusion plates 15 to move outward and extrude force to the sponge layer 14, causing the waste liquid adsorbed in the sponge layer 14 to be extruded and flow downward. The waste liquid flows through the leakage tray 16 with a mesh-like structure inside to the waste liquid collection tank. Inside the bottom surface of the collection frame 9, due to the small gap between the leakage tray 16 and the bottom surface of the waste liquid collection frame 9, the splashing generated when the waste liquid falls into the bottom surface of the waste liquid collection frame 9 is small and not obvious. Then, the waste liquid flows through the inclined guide hose 23 into the hollow rotating rod 12 below, and then flows into the drain pipe 13 to be discharged, which facilitates the discharge of waste liquid. The upper end of the drain pipe 13 is rotatably connected to the lower end of the rotating rod 12 through a sealed bearing. Therefore, the drain pipe 13 does not rotate when the rotating rod 12 rotates.

[0042] Meanwhile, when the waste liquid collection frame 9 rotates and is housed in the receiving groove 101, the protruding post 18 installed on the bottom surface of the waste liquid collection frame 9 will sequentially contact multiple triangular protrusions 19 in the sliding groove 102. The lower end of the protruding post 18 and the upper part of the protrusion 19 are both chamfered. At this time, the protrusion 19 will push the protruding post 18 to move upward, and the protruding post 18 will drive the waste liquid collection frame 9 to move upward. When the protruding post 18 moves to separate from the protrusion 19, it will move downward and reset due to its own gravity, thereby causing the protruding post 18 to drive the waste liquid collection frame 9 upward. The reciprocating shaking motion can dissipate the waste liquid in the waste liquid collection frame 9 and the sponge layer 14 into the guide tube 23, further reducing the liquid residue in the sponge layer 14 and thus improving the thoroughness of waste liquid discharge. The sponge layer 14 can be made of high-density sponge or memory foam, which makes the combination of squeezing and shaking more effective and less likely to cause deformation of the sponge layer 14. A set of waste liquid collection frames 9 can also be set on the lower left side of the extraction column body 10, so that different waste liquids can be collected and discharged separately through two sets of waste liquid collection frames 9.

[0043] Example 2: The automated solid-phase extraction instrument in this example, based on Example 1, can meet different temperature control requirements in special scenarios, thereby meeting different usage needs and avoiding the impact of temperature on the extraction process and efficiency. For the specific structure, please refer to the appendix. Figures 10-13 As shown, a flow groove 71 is provided inside the front side of the extraction column tray 7, and the bottom surface of the flow groove 71 is connected to the outer frame 20 through a through-connecting pipe 21. The outer frame 20 is fitted on the lower outer side of the extraction column body 10, and the interior of the outer frame 20 is hollow. Control cavities 22 are installed through the inner sidewall of the outer frame 20 at equal intervals. A piston assembly 221 is connected through and fitted inside one end of the control cavity 22, and the other end of the piston assembly 221 is connected to an arc-shaped clamping block 222. The inner sidewall of the clamping block 222 is in close contact with the outer side of the extraction column body 10. The space inside the control cavity 22 is connected to the space inside the outer frame 20.

[0044] When used with high-viscosity samples such as oils, concentrated biological fluids, etc., an external water supply system can be used to circulate hot water at a certain temperature into the extraction column tray 7 through the inlet and outlet pipes installed on the rear side. This ensures that hot water is injected into the flow channel 71, the connecting pipe 21, and the outer frame 20, effectively heating the outside of the extraction column body 10. Appropriate heating (30℃-40℃) can reduce sample viscosity, accelerate the sample's passage through the extraction column body 10, and prevent blockage due to viscosity. For some extremely viscous samples... For targets with weak hydrophobicity that rely on hydrophobic interactions, if there are strong hydrophobic impurities in the sample matrix, then as described above, cooling water at a certain temperature is injected into the inside of the flow channel 71, the connecting tube 21, and the outer frame 20 to cool the surface of the extraction column body 10. Appropriate cooling can enhance the hydrophobic retention of the target and reduce the non-specific adsorption of impurities, thereby indirectly improving the selectivity of extraction. Therefore, the outside of the extraction column body 10 can be heated or cooled according to the usage requirements, which can meet different temperature control requirements in special scenarios and avoid the temperature affecting the extraction work and efficiency.

[0045] When liquid is injected into the outer frame 20, the liquid enters the control chamber 22, which then pushes the piston assembly 221 and the clamping block 222 to move, so that the inner side of the arc-shaped clamping block 222 is in close contact with the outer side of the extraction column body 10. Therefore, by using multiple sets of clamping blocks 222 together, the lower outer side of the extraction column body 10 is clamped, which further improves the stability of the installation of the extraction column body 10 and prevents the extraction column body 10 from falling off accidentally. At the same time, the piston assembly 221 and the clamping block 222, which are made of copper, can conduct heat, thus further improving the heating or cooling efficiency.

[0046] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. An automated solid-phase extraction instrument, comprising a housing (1) and a sample tube rack (2) and a collection tube rack (5) installed therein, wherein an injection needle (4) is connected inside the housing (1) above the sample tube rack (2), characterized in that: Inside the outer shell (1) above the collection tube rack (5), a plunger rod (8), a fixing plate (11), an extraction column tray (7), and a waste liquid collection frame (9) are connected sequentially from top to bottom. The extraction column tray (7) contains an extraction column body (10). The waste liquid collection frame (9) contains an anti-splash assembly, and the bottom surface of the waste liquid collection frame (9) contains an auxiliary drainage assembly. The right side of the outer shell (1) contains a receiving groove (101) and a sliding groove (102). 01) has a rotating rod (12) installed inside, and a waste liquid collection frame (9) is connected through the outer side of the rotating rod (12). The snap-fit ​​block on the inner side wall of the waste liquid collection frame (9) is engaged and slidably connected with the snap-fit ​​groove on the outer side of the rotating rod (12). A double-ended screw (17) is installed in the groove on the side of the waste liquid collection frame (9) near the rotating rod (12). A pressing plate (15) is threaded on the outer side of the double-ended screw (17). A connecting rope is wound around the outer side of one end of the double-ended screw (17). 171), and the lower end of the connecting rope (171) is connected to the inside of the outer shell (1) through the guide wheel. The other end of the bidirectional screw (17) is nested with a vortex spring (172). A guide hose (23) is installed through the bottom surface of the waste liquid collection frame (9). The guide hose (23) passes through the arc-shaped groove opened inside the outer shell (1) and is connected to the lower end of the rotating rod (12). The lower end of the rotating rod (12) is hollow. The lower end of the rotating rod (12) is connected to the drain pipe ( The upper end of the drain pipe (13) is connected by a sealed bearing, and the lower end of the drain pipe (13) in the shape of "L" passes through the right side of the outer shell (1). The auxiliary drain assembly includes a protruding post (18) installed on the bottom surface of the waste liquid collection frame (9). A protrusion (19) is installed inside the slide (102). The protrusion (19) is triangular and the slide (102) is arc-shaped. The lower end of the protruding post (18) is inserted into the slide (102), and the protruding post (18) forms a lifting structure through the protrusion (19).

2. The automated solid-phase extraction apparatus according to claim 1, characterized in that: The sample tube holder (2) has a sample tube body (3) inserted inside, and the collection tube holder (5) has a collection tube body (6) inserted inside. The bottom surfaces of the sample tube holder (2) and the collection tube holder (5) as well as the side surfaces of the extraction column tray (7) are slidably connected to the inside of the outer shell (1) through a track assembly.

3. An automated solid-phase extraction apparatus according to claim 1, characterized in that: The outer side of the fixing plate (11) is fixedly connected to the inner side wall of the outer shell (1), and a plunger rod (8) is slidably connected through the inside of the fixing plate (11).

4. An automated solid-phase extraction apparatus according to claim 1, characterized in that: The outer shell (1) is equipped with four moving control mechanisms located in different positions. The upper part of the injection needle (4) and the plunger rod (8) as well as the rear side of the sample tube rack (2) and the collection tube rack (5) are all connected to the interior of the outer shell (1) by the moving control mechanisms located in the corresponding positions to form an automatic sliding structure. The moving control mechanism is an electric push rod.

5. An automated solid-phase extraction apparatus according to claim 1, characterized in that: The waste liquid collection frame (9) is equipped with a leak tray (16) with a mesh structure inside. The anti-splash component includes a sponge layer (14) symmetrically placed above the leak tray (16). A squeezing plate (15) is symmetrically arranged above the middle part of the leak tray (16). One side of the squeezing plate (15) is in contact with one side of the sponge layer (14), and the bottom surface of the squeezing plate (15) is in contact with the upper surface of the leak tray (16).

6. An automated solid-phase extraction apparatus according to claim 1, characterized in that: The front side of the extraction column tray (7) is provided with a flow groove (71), and the bottom surface of the flow groove (71) is connected to the outer frame (20) through a through-installed connecting pipe (21). The outer frame (20) is fitted on the lower outer side of the extraction column body (10), and the interior of the outer frame (20) is hollow.

7. An automated solid-phase extraction apparatus according to claim 6, characterized in that: The inner wall of the outer frame (20) is provided with equal spacing through control cavities (22), and one end of the control cavity (22) is connected to a piston assembly (221) through and fitted. The other end of the piston assembly (221) is connected to an arc-shaped clamping block (222), and the inner wall of the clamping block (222) is in contact with the outer side of the extraction column body (10). The space inside the control cavity (22) is connected to the space inside the outer frame (20).

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