Hot patch plaster and preparation method thereof

Abstract

The invention relates to a hot patch plaster and a preparation method thereof, the hot patch plaster is prepared by combining a shape-fixable traditional Chinese medicine gel layer with a non-woven fabric substrate as a carrier of traditional Chinese medicine components, and then combining the non-woven fabric substrate with a heating substrate. The heating substrate is beneficial to continuous constant-temperature heating of the traditional Chinese medicine gel layer to promote transdermal drug delivery and slow release of effective components, the drug effect utilization rate and the application convenience are improved, and a patient can be treated at any part and in any occasion, so that the use limitation of a traditional therapy method is overcome.

Description

Technical Field

[0001] This application belongs to the field of heat-applied plaster technology, and in particular relates to a heat-applied plaster and its preparation method. Background Technology

[0002] Drugs that promote blood circulation, remove blood stasis, relieve pain, and unblock meridians are commonly used to treat rheumatic pain, joint pain, and muscle stiffness. Soaking or decocting these drugs and then applying them as a hot compress to the affected area can relieve muscle pain and achieve good therapeutic effects. For example, decocting these drugs and using them for foot baths can effectively promote blood circulation and relieve pain. However, there are significant limitations to using these decocted drugs:

[0003] (1) It requires hot water, containers and heating conditions, making it inconvenient to carry and use;

[0004] (2) The duration of drug efficacy is short, and the therapeutic effect weakens rapidly after cooling;

[0005] (3) Low drug utilization rate and low drug concentration;

[0006] (4) Its application is limited and it is not convenient to use in many places. For example, it is difficult to soak painful areas such as the neck, shoulders, waist and back. Using a towel soaked in the medicine solution also faces the problem of rapid temperature drop. Summary of the Invention

[0007] The technical problem to be solved by this invention is to address the limitation in the practical application of drugs that promote blood circulation, remove blood stasis, relieve pain, and unblock meridians in the prior art, thereby providing a hot patch plaster and its preparation method.

[0008] The technical solution adopted by this invention to solve its technical problem is:

[0009] A heat-applied plaster, comprising:

[0010] Non-woven fabric substrate;

[0011] The traditional Chinese medicine gel layer comprises medicinal powder and a matrix; the traditional Chinese medicine gel layer is adhered to the non-woven fabric substrate;

[0012] A release layer, wherein the release layer is at least partially attached to one side of the traditional Chinese medicine gel layer;

[0013] A heating substrate is attached to one side of the nonwoven fabric substrate.

[0014] Preferably, in the hot patch plaster of the present invention, the powder components include: 3 parts of Ligusticum chuanxiong, 3 parts of Angelica sinensis, 2 parts of Paeonia lactiflora, 2 parts of Asarum heterotropoides, and 3 parts of Angelica pubescens.

[0015] Preferably, in the hot-dip medicated plaster of the present invention, the powder components further include: 3 parts mulberry twigs, 2 parts Trachelospermum jasminoides, 2 parts Artemisia argyi, and 3 parts elderberry.

[0016] Preferably, in the heat-applied plaster of the present invention, the powder has a mesh size of 50-200.

[0017] This invention provides a method for preparing a heat-sensitive plaster, comprising the following steps:

[0018] After the prepared Chinese herbal gel has cooled, it is added to the plaster storage machine for later use.

[0019] The nonwoven fabric substrate is tensioned and transported using rollers;

[0020] The herbal gel is discharged onto the non-woven fabric substrate at regular intervals and in a measured quantity using a plaster storage machine. The herbal gel is then extruded into a sheet shape that meets the preset specifications using a die-casting mold and adhered to the non-woven fabric substrate to form a tablet.

[0021] A release layer is applied to the tablet, and then the release layer and the non-woven fabric base are cut together to a certain size to obtain a medicated patch;

[0022] A heating substrate is transported using a conveyor belt, and an industrial robot picks up the medicated patch and attaches it to the heating substrate. The patch is then adhered to the heating substrate by hot pressing to obtain a heat-applied plaster.

[0023] Preferably, in the preparation method of the hot-dip medicated plaster of the present invention, the step of decocting the traditional Chinese medicine gel includes:

[0024] Add the base to the pot, grind the following herbs into a fine powder of 50-200 mesh: Ligusticum chuanxiong, Angelica sinensis, Paeonia lactiflora, Asarum heterotropoides, Angelica pubescens, Morus alba twigs, Trachelospermum jasminoides, Artemisia argyi, and Sambucus chinensis. Add the powder to the iron pot and stir continuously to fully blend the powder with the base, and boil it into a gel.

[0025] Preferably, in the preparation method of the heat-applied plaster of the present invention, the step of covering the medicated tablet with a release layer includes: firstly attaching release paper to the edge of the medicated tablet exposed by the non-woven fabric substrate, and then covering the medicated tablet with a release film, so that the release film covers the traditional Chinese medicine gel, the release paper and the non-woven fabric substrate.

[0026] Preferably, in the preparation method of the heat-sensitive plaster of the present invention, the step of using an industrial robot to grasp the plaster and attach it to the heating substrate includes: first, using a camera to capture the position information of the plaster and the heating substrate, performing positioning through an image processing algorithm, and then using a robot to grasp the plaster and attach it to the heating substrate.

[0027] Preferably, the method for preparing the hot-applied plaster of the present invention further includes arranging the plaster storage machine, the die-casting mold, the release layer application equipment, the cutting equipment, and the industrial robot sequentially along the transport path of the nonwoven fabric substrate.

[0028] Preferably, the preparation method of the heat-plaster plaster of the present invention further includes:

[0029] After obtaining the heat-applied plaster, the integrity, positional accuracy, and adhesion quality of the heat-applied plaster are checked by sensors or a vision system; qualified and unqualified products are distinguished according to the inspection results, and unqualified products are removed by machine, while qualified products are collected and packaged.

[0030] The beneficial effects of this invention are as follows: The hot patch of this invention uses a traditional Chinese medicine gel layer with a fixed shape combined with a non-woven fabric base as a carrier of traditional Chinese medicine ingredients. The non-woven fabric base is then combined with a heating base. The heating base helps the traditional Chinese medicine gel layer achieve continuous constant temperature heating, promotes transdermal drug delivery and sustained release of effective ingredients, improves drug efficacy and applicability, and allows patients to receive treatment at any location and in any situation, thereby overcoming the limitations of traditional therapies.

[0031] The hot-dip medicated plaster preparation method of the present invention achieves the transfer of non-woven fabric substrate through a simple roller conveyor, and uses the non-woven fabric substrate as the conveying basis for the traditional Chinese medicine gel process, thereby realizing the sequential formation of tablets, attachment of release layer, and formation of medicated plaster; it also uses a conveyor belt to transport the heating substrate, and uses an industrial robot to grab and attach the medicated plaster to the heating substrate, so that the medicated plaster is firmly attached to the heating substrate. The combination of the two production lines realizes the synthesis of hot-dip medicated plaster. Attached Figure Description

[0032] The technical solution of this application will be further described below with reference to the accompanying drawings and embodiments.

[0033] Figure 1 This is a schematic diagram of the structure of the heat-adhesive plaster according to an embodiment of this application;

[0034] Figure 2 This is a schematic diagram of the structure of each layer of the heat-adhesive plaster according to an embodiment of this application;

[0035] Figure 3 This is a schematic diagram of the preparation method of the heat-applied plaster according to an embodiment of this application.

[0036] The attached figures are labeled as follows:

[0037] 1. Traditional Chinese medicine gel layer; 2. Release layer; 21. Release paper; 22. Release film;

[0038] 3. Heating substrate; 4. Non-woven fabric substrate; 5. Plaster storage machine; 6. Roller;

[0039] 7. Die-casting molds; 8. Tablets; 9. Cutting equipment; 10. Medicated patches;

[0040] 11. Industrial robots; 12. Vision systems; 100. Heat-applied plasters. Detailed Implementation

[0041] It should be noted that, unless otherwise specified, the embodiments and features described in this application can be combined with each other.

[0042] In the description of this application, it should be understood that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicating orientation or positional relationships based on the orientation or positional relationships shown in the accompanying drawings, are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as limiting the scope of protection of this application. Furthermore, the terms "first," "second," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, features defined with "first," "second," etc., may explicitly or implicitly include one or more of that feature. In the description of this invention, unless otherwise stated, "a plurality of" means two or more.

[0043] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection between two components. Those skilled in the art will understand the specific meaning of the above terms in this application based on the specific circumstances.

[0044] The technical solution of this application will now be described in detail with reference to the accompanying drawings and embodiments.

[0045] Example 1

[0046] This embodiment provides a heat-applied plaster, such as... Figure 1 , Figure 2 As shown, it includes:

[0047] Non-woven fabric substrate 4;

[0048] The traditional Chinese medicine gel layer 1 comprises medicinal powder and a matrix; the traditional Chinese medicine gel layer 1 is adhered to the non-woven fabric substrate 4;

[0049] Release layer 2, wherein the release layer 2 is at least partially attached to one side of the traditional Chinese medicine gel layer 1;

[0050] Heating substrate 3 is attached to one side of the nonwoven fabric substrate 4. The heating substrate 3 includes chemical heating components and can achieve self-heating through chemical reaction.

[0051] The heat-sensitive plaster provided in this embodiment uses a traditional Chinese medicine gel layer 1 with a fixed shape combined with a non-woven fabric base 4 as a carrier of traditional Chinese medicine ingredients. The non-woven fabric base 4 is then combined with a heating base 3. The heating base 3 helps the traditional Chinese medicine gel layer 1 to achieve continuous constant temperature heating, promote transdermal drug delivery and sustained release of effective ingredients, improve drug utilization rate and applicability, and allow patients to receive treatment at any site and in any situation, thereby overcoming the limitations of traditional therapies.

[0052] In an optional embodiment, the powder comprises: 3 parts Ligusticum chuanxiong, 3 parts Angelica sinensis, 2 parts Paeonia lactiflora, 2 parts Asarum heterotropoides, and 3 parts Angelica pubescens. The core characteristics of this powder are precise targeting, synergistic effect, and mild medicinal properties. Its core function is to invigorate blood circulation and dispel wind, targeting the core pathogenesis of pain and relieving various types of pain. Its formulation balances efficacy and safety, making it suitable for preparing external patches. Through skin penetration, it exerts local effects of unblocking meridians, relieving pain, and eliminating dampness, primarily applicable to rheumatic bone pain, muscle soreness, and joint stiffness.

[0053] In an optional embodiment, the powder further comprises: 3 parts mulberry twigs, 2 parts *Trachelospermum jasminoides*, 2 parts mugwort leaves, and 3 parts elderberry. This component enhances the muscle-relaxing effect of the powder.

[0054] In an optional embodiment, the powder has a mesh size of 50 to 200 mesh, and actual measurements show that the powder has good formability at this mesh size.

[0055] This embodiment provides a method for preparing a heat-sensitive plaster, such as... Figure 3 As shown, it includes the following steps:

[0056] After the prepared Chinese herbal gel has cooled, add it to the plaster storage machine 5 for later use;

[0057] The nonwoven fabric substrate 4 is tensioned and transported using roller 6;

[0058] The traditional Chinese medicine gel is discharged into the non-woven fabric substrate 4 at regular intervals and in a quantitative manner using the plaster storage machine 5, and the traditional Chinese medicine gel is extruded into a sheet shape that meets the preset specifications through the die casting mold 7, and then adhered to the non-woven fabric substrate 4 to form a tablet 8.

[0059] A release layer 2 is covered on the tablet 8, and then the release layer 2 and the non-woven fabric base 4 are cut together to a certain size to obtain the patch 10;

[0060] The heating substrate 3 is transported by a conveyor belt, and the medicated patch 10 is picked up and attached to the heating substrate 3 by an industrial robot 11. Then, the medicated patch 10 is attached to the heating substrate 3 by hot pressing to obtain the heat-applied plaster 100.

[0061] The method for preparing the heat-contact plaster provided in this embodiment uses a simple roller conveyor to transport the non-woven fabric substrate 4, and uses the non-woven fabric substrate 4 as the conveying basis for the traditional Chinese medicine gel process, to sequentially realize the forming of the medicated tablet 8, the attachment of the release layer 2, and the forming of the medicated patch 10; a conveyor belt is also used to transport the heating substrate 3, and an industrial robot 11 is used to grab and attach the medicated patch 10 to the heating substrate 3, so that the medicated patch 10 is firmly attached to the heating substrate 3. The two production lines are combined to realize the synthesis of the heat-contact plaster 100.

[0062] In an optional embodiment of the preparation method, the step of decocting the traditional Chinese medicine gel includes:

[0063] Add the base (medical hot melt adhesive, white oil) to the pot, and grind the following herbs into a fine powder of 50-200 mesh: Ligusticum chuanxiong, Angelica sinensis, Paeonia lactiflora, Asarum sieboldii, Angelica pubescens, Morus alba twigs, Trachelospermum jasminoides, Artemisia argyi, and Sambucus chinensis. Add the powder to the iron pot and stir continuously to fully blend the powder with the base, and cook it into a gel.

[0064] In an optional embodiment, the step of covering the release layer 2 onto the tablet 8 includes: firstly attaching release paper 21 to the edge of the exposed nonwoven fabric substrate 4 of the tablet 8, and then covering the tablet 8 with a release film 22, so that the release film 22 covers the herbal gel, the release paper 21, and the nonwoven fabric substrate 4. This double-layer release design makes the separation operation of the release layer 2 simpler and more effective, and can improve the user experience.

[0065] In an optional embodiment, the step of using an industrial robot 11 to pick up the medicated patch 10 and attach it to the heating substrate 3 includes: first, using a camera to capture the positional information of the medicated patch 10 and the heating substrate 3, performing positioning through an image processing algorithm, and then using the robot to pick up the medicated patch 10 and attach it to the heating substrate 3. In this embodiment, by using image recognition, the medicated patch 10 on the first production line is accurately identified and then transferred to the second production line, ensuring that the medicated patch 10 is accurately bonded to the heating substrate 3.

[0066] In an alternative embodiment, such as Figure 3 As shown, the preparation method of the heat-applied plaster in this embodiment further includes arranging the plaster storage machine 5, the die-casting mold 7, the release layer 2 application equipment, the cutting equipment 9, and the industrial robot 11 sequentially along the transport path of the nonwoven fabric substrate 4. In this embodiment, this arrangement enables each piece of equipment to operate sequentially according to the process, thus accelerating the entire production process.

[0067] In an optional embodiment, the method for preparing the heat-sensitive plaster further includes:

[0068] After obtaining the heat patch 100 steps, as follows Figure 3 As shown, the integrity, positional accuracy, and adhesion quality of the heat-adhesive plaster 100 are inspected using sensors or a vision system 12. Based on the inspection results, qualified and unqualified products are distinguished, and unqualified products are removed by machine, while qualified products are collected and packaged. This embodiment achieves the removal of defective products. The vision system 12 can perform a comprehensive inspection of the integrity, positional accuracy, and adhesion quality of the heat-adhesive plaster 100. The main defects that may occur in the production process of the heat-adhesive plaster 100 in this embodiment are basically incompleteness, inaccurate adhesion position, and loose adhesion. The working principle of the vision system 12 meets the requirements of quality inspection.

[0069] In an optional embodiment, the method for preparing the heat-sensitive plaster further includes: automatically collecting qualified products, stacking or rolling them up, and completing the packaging.

[0070] Example 2

[0071] This embodiment tests the effectiveness of the heat-applied plaster 100 provided in Example 1.

[0072] To verify the actual application effect of the heat patch 100 in Example 1, 122 patients with musculoskeletal discomfort were selected for clinical observation. Each patient used the patch continuously for 3 days (1 patch per day, 10 hours per patch). The improvement of symptoms and adverse reactions during the use period were observed. The specific results are as follows:

[0073] Basic information of the subjects

[0074] The subjects included different types of illnesses, aged 22 to 65 years, including 68 males and 54 females. All subjects were excluded due to contraindications such as broken skin, severe allergies, and acute infections. The specific distribution of illnesses is as follows.

[0075] Lumbar muscle strain: 36 cases (lower back pain and limited mobility caused by prolonged sitting or physical labor);

[0076] Lumbar disc herniation (mild to moderate): 18 cases (accompanied by radiating pain in the lower extremities or stiffness in the lower back);

[0077] Postoperative rehabilitation of rotator cuff injury: 15 cases (1-3 months postoperatively, with limited shoulder movement and soreness);

[0078] Cervical and shoulder syndrome: 27 cases (neck stiffness accompanied by shoulder pain and difficulty raising the upper limbs);

[0079] Knee joint pain due to cold and dampness: 26 cases (worsened by cold, accompanied by popping or dull pain during activity);

[0080] Performance Evaluation Criteria

[0081] The evaluation criteria consisted of "the degree of symptom improvement + the satisfaction of the subjects".

[0082] Significant effect: Relief of core symptoms such as pain and stiffness by ≥70%, basic recovery of mobility, and no obvious discomfort;

[0083] Effective: Core symptoms are relieved by 30%-70%, and mobility is improved, with occasional mild soreness;

[0084] Ineffective: Symptom relief <30%, or significant skin irritation reaction occurs.

[0085] Satisfaction rating: A 10-point scale is used, with ≥8 points indicating "very satisfied", 6-7 points indicating "basically satisfied", and <6 points indicating "unsatisfied".

[0086] Observation results

[0087] Overall results: Among the 122 subjects, 89 cases (72.9%) showed significant effect, 31 cases (25.4%) showed effect, and 2 cases (1.6%) showed no effect, with a total effective rate of 98.4%. The average subject satisfaction score was 8.7, with 95 cases (77.8%) being very satisfied, 25 cases (20.5%) being basically satisfied, and 2 cases (1.6%) being dissatisfied.

[0088] Disease differentiation effect

[0089] Lumbar muscle strain: 28 cases showed significant effect, 8 cases showed effect, and 0 cases showed no effect, with a total effective rate of 100%. Most subjects reported that their lower back pain was significantly reduced after using one patch. In the satisfaction evaluation, 29 cases were very satisfied, 7 cases were basically satisfied, and 0 cases were dissatisfied, with a satisfaction rate of 100%.

[0090] Lumbar disc herniation: 11 cases showed significant improvement, 6 cases showed improvement, and 1 case showed no improvement, with a total effective rate of 94.4%. Those with significant improvement experienced significant relief of radiating pain in the lower extremities. In the satisfaction evaluation, 12 cases were very satisfied, 5 cases were basically satisfied, and 1 case was dissatisfied, with a satisfaction rate of 94.4%.

[0091] Postoperative rotator cuff injury: 9 cases showed significant improvement, 5 cases showed improvement, and 1 case showed no improvement, with a total effective rate of 93.3%. The traction pain when raising the arm was significantly relieved in the subjects after surgery. In the satisfaction evaluation, 12 cases were very satisfied, 2 cases were basically satisfied, and 1 case was dissatisfied, with a satisfaction rate of 93.3%.

[0092] Cervical and shoulder syndrome: 20 cases showed significant effect, 7 cases showed effect, and 0 cases showed no effect, with a total effective rate of 100%. The stiffness in the neck basically disappeared after using 2 patches. In the satisfaction evaluation, 23 cases were very satisfied, 4 cases were basically satisfied, and 0 cases were dissatisfied, with a satisfaction rate of 100%.

[0093] For knee joint pain due to cold and dampness: 21 cases showed significant improvement, 4 cases showed improvement, and 1 case showed no improvement, with a total effective rate of 96.2%. Symptoms that worsened with cold were significantly improved. In the satisfaction evaluation, 19 cases were very satisfied, 7 cases were basically satisfied, and 0 cases were dissatisfied, with a satisfaction rate of 100%.

[0094] Safety results: No adverse reactions such as skin burns, blisters or allergic rashes occurred in any of the subjects, and the safety profile was as expected.

[0095] Based on the above-described preferred embodiments according to this application, and through the foregoing description, those skilled in the art can make various changes and modifications without departing from the technical concept of this application. The technical scope of this application is not limited to the contents of the specification, but must be determined according to the scope of the claims.

Claims

1. A heat-applied plaster, characterized in that, include: Non-woven fabric substrate (4); The traditional Chinese medicine gel layer (1) comprises medicinal powder and matrix; the traditional Chinese medicine gel layer (1) is adhered to the non-woven fabric substrate (4); Release layer (2), said release layer (2) is at least partially attached to one side of the traditional Chinese medicine gel layer (1); Heating substrate (3) is attached to one side of the nonwoven substrate (4).

2. The heat-applied plaster according to claim 1, characterized in that, The powder consists of the following components: 3 parts of Ligusticum chuanxiong, 3 parts of Angelica sinensis, 2 parts of Paeonia lactiflora, 2 parts of Asarum heterotropoides, and 3 parts of Angelica pubescens.

3. The heat-applied plaster according to claim 2, characterized in that, The powder also includes the following components: 3 parts mulberry twigs, 2 parts star jasmine, 2 parts mugwort leaves, and 3 parts elderberry.

4. The heat-applied plaster according to claim 2 or 3, characterized in that, The powder has a mesh size of 50-200.

5. A method for preparing a heat-applied plaster, characterized in that, Includes the following steps: After the prepared Chinese herbal gel has cooled, add it to the plaster storage machine (5) for later use; The nonwoven fabric substrate (4) is tightened and transported using rollers (6); The traditional Chinese medicine gel is discharged into the non-woven fabric substrate (4) at regular intervals and in a quantitative manner using a plaster storage machine (5), and the traditional Chinese medicine gel is extruded into a sheet shape that meets the preset specifications through a die-casting mold (7), and then adhered to the non-woven fabric substrate (4) to form a tablet (8). A release layer (2) is covered on the tablet (8), and then the release layer (2) and the non-woven fabric base (4) are cut together to a certain size to obtain a patch (10). The heating substrate (3) is transported by a conveyor belt, and the medicated patch (10) is picked up and attached to the heating substrate (3) by an industrial robot (11). The medicated patch (10) is then attached to the heating substrate (3) by hot pressing to obtain a hot patch plaster (100).

6. The method for preparing the heat-applied plaster according to claim 5, characterized in that, The steps for preparing the herbal gel include: Add the base to the pot, grind the following herbs into a fine powder of 50-200 mesh: Ligusticum chuanxiong, Angelica sinensis, Paeonia lactiflora, Asarum heterotropoides, Angelica pubescens, Morus alba twigs, Trachelospermum jasminoides, Artemisia argyi, and Sambucus chinensis. Add the powder to the iron pot and stir continuously to fully blend the powder with the base, and boil it into a gel.

7. The method for preparing the heat-applied plaster according to claim 5, characterized in that, The step of covering the release layer (2) on the tablet (8) includes: first attaching release paper (21) to the edge of the tablet (8) where the nonwoven fabric substrate (4) is exposed, and then covering the tablet (8) with release film (22) so that the release film (22) covers the traditional Chinese medicine gel, the release paper (21) and the nonwoven fabric substrate (4).

8. The method for preparing the heat-applied plaster according to claim 5, characterized in that, The step of using an industrial robot (11) to pick up the patch (10) and attach it to the heating substrate (3) includes: first, using a camera to capture the position information of the patch (10) and the heating substrate (3), locating them using an image processing algorithm, and then using a robot to pick up the patch (10) and attach it to the heating substrate (3).

9. The method for preparing the heat-applied plaster according to any one of claims 5-7, characterized in that, It also includes arranging the plaster storage machine (5), the die-casting mold (7), the release layer (2) attachment equipment, the cutting equipment, and the industrial robot (11) sequentially along the transmission path of the nonwoven fabric substrate (4).

10. The method for preparing the heat-plaster plaster according to any one of claims 5-7, characterized in that, The preparation method of the heat-plaster plaster also includes: After obtaining the heat patch (100), the integrity, positional accuracy and adhesion quality of the heat patch (100) are checked by a sensor or vision system (12); qualified products and unqualified products are distinguished according to the inspection results, and unqualified products are removed by machine, while qualified products are collected and packaged.

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