Integrated multifunctional cell reinfusion device

Abstract

The invention discloses an integrated multifunctional cell transfusion device which comprises a box body, a transfusion bag placing groove and a transfusion bag placing groove are formed in the box body, the transfusion bag placing groove is communicated with the transfusion bag placing groove, a cell transfusion bag is arranged in the transfusion bag placing groove, a cell transfusion bag is arranged in the transfusion bag placing groove, and the transfusion bag placing groove is communicated with the transfusion bag placing groove. The cell infusion bag is connected with the cell infusion bag through a filter tube, a notch is formed in the side wall of one end, far away from the transportation placing groove, of the box body, a connector connected with a blood transfusion tube is arranged on the cell infusion bag, and the connector is located on the outer side of the notch.

Description

[0001] The present application is a divisional application of the invention patent application with application number CN202111643996.4 and invention name "an integrated multifunctional cell return device", and the parent application has an application date of December 29, 2021. TECHNICAL FIELD

[0002] The present application belongs to the technical field of medical machinery, and specifically relates to an integrated multifunctional cell return device. BACKGROUND

[0003] Cell therapy technology refers to transplanting or inputting normal or bioengineered human cells into the patient's body. The newly input cells can replace, repair damaged cells, or stimulate the immune system, have stronger immune killing function, and thus achieve the purpose of treating diseases. Generally, cell therapy includes two categories of immune cell therapy and stem cell therapy. Immune cell therapy includes targeted dendritic cell therapy technology (T-DC technology), CIK cell therapy technology, NK cell therapy technology, etc.; stem cell therapy shows higher and higher application value in treating cancer, viral diseases, blood diseases, cardiovascular diseases, diabetes, Alzheimer's disease, beauty anti-aging health care, etc.

[0004] Cell return is an important link of cell therapy. At present, cell return bags are mostly used for cell return. However, the following problems exist in the transportation and return process of the cell return bag: (1) the generated shaking during transportation leads to easy extrusion of the cell return bag, and the cooling effect is poor; (2) when the cell return bag is used for cell return, the cells in the return suspension are easy to form clusters or adhere to the inner wall of the cell return bag, which may cause the cells in the cell return bag not to be completely returned to the patient, resulting in cell waste, or even cause medical accidents due to the blockage of blood vessels by the cell clusters; (3) during the cell return process, medical staff frequently shake the cell solution, which consumes manpower, and when the patient is given cell infusion, the cells are easy to produce sediment due to long-term static placement, thereby affecting the treatment effect of the patient; (4) it is difficult to extract a sample before return, which affects the sealing property of the cell return bag. SUMMARY

[0005] The present application proposes an integrated multifunctional cell return device to solve the above technical problems.

[0006] The technical scheme adopted by the present application is as follows: An integrated multifunctional cell return device comprises: The box body is provided with a cell reinfusion bag placement slot and an infusion bag placement slot, which are connected. A cell reinfusion bag is placed in the cell reinfusion bag placement slot, and a cell infusion bag is placed in the infusion bag placement slot. A notch is provided on the side wall of the box body away from the transport placement slot. A connector for connecting to the infusion tube is provided on the cell infusion bag, which is located outside the notch. Movable cavities are provided inside the two symmetrical side walls of the infusion bag placement slot. A cell injection interface is also provided on the cell reinfusion bag. A filter tube connects the cell reinfusion bag to the cell infusion bag. The filter tube includes an upper tube and a lower tube. The upper tube is connected to the lower tube via a tear-off ring. A sealing plug is installed inside the upper tube. The inner wall of the tear-off ring has a bevel along its circumference. The lower end of the sealing plug fits against the bevel to seal the upper tube. A limiting cylinder is installed outside the sealing plug, with its lower end located on the upper surface of the tear-off ring. A frustum is installed inside the lower tube along its circumference, dividing the lower tube into a connecting chamber and a filtering chamber. Multiple coaxial limiting grooves are provided on the inner walls of the connecting chamber and the upper tube along their circumference. Multiple limiting grooves that mate with the limiting grooves are provided on the outer wall of the limiting cylinder along its circumference. The limiting cylinder has at least two limiting blocks arranged along its circumference inside. The limiting blocks are attached to the upper end of the diaphragm plug. When the cells in the cell reinfusion bag are filtered into the cell infusion bag, the tear ring on the filter tube is manually torn off. The limiting cylinder and the diaphragm plug lose their support and fall into the pipeline under the action of gravity. The limiting cylinder stops falling after the bottom contacts the frustum. The positioning block is squeezed into the positioning groove under the action of the second compression spring to fix the limiting cylinder. The diaphragm plug continues to fall and squeezes the movable plug down, thereby exposing the primary filtration hole on the side wall of the filter bucket. The cells then undergo the first filtration through the primary filtration hole and then the second filtration through the fine filtration hole on the support plate, filtering out cell clusters or cell clumps. A turntable is disposed within the movable cavity. A rotating shaft is located on the end face of the turntable away from the infusion bag placement slot. The rotating shaft is connected to a drive motor via a coupling and a reducer. The drive motor, coupling, and reducer are housed in a mounting box on the outer wall of the housing. An inclined surface is provided on the end face of the turntable near the infusion bag placement slot. A squeezing rod is also disposed within the movable cavity. One end of the squeezing rod is in contact with the inclined surface, and the other end is located within a T-shaped guide groove on the inner wall of the movable cavity. The T-shaped groove is connected to the infusion bag placement slot via a receiving groove. A squeezing block is provided at the other end of the squeezing rod, located within the receiving groove. A third compression spring is provided on the outer wall of the squeezing rod. One end of the third spring is connected to the inner wall of the T-shaped guide groove, and the other end is connected to the inner end face of the squeezing block. Multiple squeezing protrusions are provided on the outer end face of the squeezing block. A bidirectional control switch is disposed on the cell infusion bag. The bidirectional control switch includes a fixed connector and a movable connector. The fixed connector is connected to the cell infusion bag, and the movable connector is threadedly connected to the fixed connector.

[0007] Preferably, the enclosure is made of a material with good thermal conductivity.

[0008] Preferably, the upper end of the box is provided with a transparent cover, which is hinged to one side wall of the box via a hinge and connected to the other side wall of the box via a magnet.

[0009] Preferably, the lower end of the filtration chamber is connected to the cell infusion bag. A filter bucket and a support plate are disposed within the filtration chamber. The support plate is located below the filter bucket and connected to the inner wall of the filtration chamber. The upper end of the filter bucket abuts against the lower end face of the frustum. A movable plug and a first compression spring are disposed within the filter bucket. The lower end of the first compression spring is connected to the bottom wall of the filter bucket, and its upper end is connected to the lower end of the movable plug. The upper end of the movable plug is fitted against the inner wall of the frustum. An adapter groove is provided at the top of the upper end of the movable plug, and the bottom of the lower end of the partition plug is located within the adapter groove. Multiple primary filtration holes are provided along the circumference of the side wall of the filter bucket, and fine filtration holes are provided on the support plate.

[0010] Preferably, a first positioning groove is provided between two adjacent limiting strips, a groove is provided on the inner wall of the upper pipe, a first positioning element coaxial with the first positioning groove is provided in the groove, a groove is also provided on the outer wall of the limiting cylinder between two adjacent limiting strips, a second positioning element is provided in the groove, and a second positioning groove coaxial with the second positioning element is provided on the inner wall of the connecting cavity.

[0011] Preferably, the first positioning member and the second positioning member have the same structure, both including a telescopic rod and a second compression spring. One end of the telescopic rod is connected to the inner wall of the groove, and the other end is provided with a positioning block. The second compression spring is sleeved on the outside of the telescopic rod, and one end is connected to the fixing block, and the other end is connected to the inner wall of the groove.

[0012] Preferably, the pore size of the fine filter pore is 50-100 μm.

[0013] Preferably, a flow-limiting cavity is provided at one end of the fixed joint near the movable joint. A coaxial guide tube and a movable tube are arranged within the flow-limiting cavity. The inner end face of the guide tube is fixedly connected to the inner end wall of the flow-limiting cavity. A guide hole is provided along the circumference of the guide tube. The movable tube is located inside the guide tube and has convection holes along its circumference. Multiple mounting slots are provided along the circumference of the inner end wall of the flow-limiting cavity. A fourth compression spring is provided in each mounting slot. One end of the fourth compression spring is connected to the inner end wall of the mounting slot, and the other end is connected to the inner end face of the movable tube. A disc is provided inside the movable joint. The disc is connected to the inner wall of the movable joint by support plates on all four sides. An adjusting cylinder is provided at one end of the disc near the fixed joint. The free end of the adjusting cylinder is located inside the guide cylinder. When sampling is required, the movable joint is rotated towards the fixed joint. The adjusting cylinder squeezes the movable cylinder and moves it into the limiting cavity. The convection hole and the guide hole are aligned. The fourth compression spring is compressed into the mounting groove. The cells pass through the convection hole, the guide hole and the limiting cavity in sequence to enter the movable joint, thereby realizing sampling. When the sampling is completed, the movable joint is rotated outward. The movable cylinder loses its compression and is reset under the action of the fourth compression spring. The convection hole and the guide hole are misaligned, thus achieving a seal.

[0014] Compared with the prior art, the beneficial effects of the present invention are: 1. This invention adds a cell infusion bag, which is connected to the cell reinfusion bag via a filter tube. Before reinfusion, to prevent cell clusters in the reinfusion suspension from causing vascular blockage, the cells are filtered through the filter tube before entering the cell infusion bag for reinfusion. Filtration can be achieved simply by tearing off the tear ring, making the operation simple and the filtration effect good.

[0015] 2. In this invention, the cell reinfusion bag and cell infusion bag are placed inside the box. The box material is made of a material with good thermal conductivity, which can provide good fixation and cushioning on the one hand, and maintain good cooling effect on the other.

[0016] 3. In the reinfusion process, the present invention incorporates a squeezing component inside the housing. This squeezing component consists of a drive motor, coupling, reducer, turntable, squeezing rod, squeezing block, and a third compression spring. One side of the turntable is designed as an inclined surface. As the drive motor drives the turntable to rotate, the inclined surface pushes the squeezing rod, thereby pulling the squeezing block to regularly squeeze the cell infusion bag. This replaces the frequent shaking by personnel and avoids sedimentation during cell reinfusion.

[0017] 4. In this invention, a bidirectional control switch is designed on the cell infusion bag. This bidirectional control switch includes a fixed connector and a movable connector. A flow-limiting cavity is provided at the end of the fixed connector near the movable connector. A coaxial flow guide tube and a movable tube are arranged within the flow-limiting cavity. The inner end face of the flow guide tube is fixedly connected to the inner end wall of the flow-limiting cavity. A flow guide hole is provided along the circumference of the flow guide tube. The movable tube is located inside the flow guide tube and has a convection hole provided along its circumference. Multiple mounting grooves are provided along the circumference of the inner end wall of the flow-limiting cavity. A fourth compression spring is provided in each mounting groove. One end of the spring is connected to the inner wall of the mounting groove, and the other end is connected to the inner end face of the movable cylinder. A disc is provided inside the movable joint, and the disc is connected to the inner wall of the movable joint through support plates. An adjusting cylinder is provided at the end of the disc near the fixed joint, and the free end of the adjusting cylinder is located inside the guide cylinder. When sampling is required, the sampling tube is inserted into the free end of the movable joint, and the movable joint is rotated, so that the adjusting cylinder squeezes the movable cylinder to move towards the inner end face of the flow limiting cavity, and the convection hole and the guide hole are aligned. The cells in the fixed joint flow through the convection hole and the guide hole in sequence into the movable joint, thereby realizing sampling. Attached Figure Description

[0018] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0019] Figure 1 The diagram shown is a structural schematic of an integrated multifunctional cell reinfusion device in this embodiment. Figure 2 The diagram shown is a schematic of an integrated multifunctional cell reinfusion device after the casing has been removed. Figure 3 As shown Figure 2 A schematic diagram of the middle filter tube; Figure 4 As shown Figure 3 Enlarged view of point A in the middle; Figure 5 As shown Figure 4 Enlarged view of point B in the middle; Figure 6 The diagram shows the filter tube in the filtration state. Figure 7 The image shown is a top sectional view of the box. Figure 8 As shown Figure 7 Enlarged view of point C in the middle; Figure 9 The diagram shown is a schematic of the turntable; Figure 10 The image shown is a cross-sectional view of a bidirectional control switch. Figure 11 The diagram shows a bidirectional control switch in the ON position.

[0020] Among them, 1. Box body; 101. Infusion bag placement slot; 102. Infusion bag placement slot; 103. Notch; 104. Movable cavity; 105. T-shaped guide groove; 106. Reception groove; 2. Cell reinfusion bag; 3. Filter tube; 301. Upper pipe; 302. Tear ring; 3021. Inclined surface; 303. Lower pipe; 304. Limiting cylinder; 305. Limiting strip; 306. Limiting block; 307. Partition plug; 308. First positioning groove; 309. Second positioning groove; 310. Telescopic rod; 311. Second compression spring; 312. Positioning block; 313. Frustum; 314. Connecting cavity; 315. Filter cavity; 316. Filter barrel; 3161. Primary filter hole; 317. Movable plug; 318. First compression spring; 319. Support plate; 3191. Fine filter hole; 4. Cell infusion bag; 5. Cell injection interface; 6. Two-way control switch; 601. Fixed joint; 602. Movable joint; 603. Flow limiting cavity; 604. Flow guide tube; 605. Movable tube; 606. Flow guide hole; 607. Convection hole; 608. Mounting groove; 609. Fourth compression spring; 610. Disc; 611. Support plate; 612. Adjusting tube; 7. Connector; 8. Mounting box; 9. Transparent cover; 10. Hook; 11. Drive motor; 12. Reducer; 13. Coupling; 14. Shaft; 15. Turntable; 1501. Inclined surface; 16. Extrusion rod; 17. Extrusion block; 18. Extrusion protrusion; 19. Third compression spring. Detailed Implementation

[0021] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The components of the embodiments of the present invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0022] Therefore, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the invention without inventive effort are within the scope of protection of the invention.

[0023] Example 1 This embodiment specifically provides an integrated multifunctional cell reinfusion device, such as... Figures 1-6 As shown, the device includes a housing 1, on which a reinfusion bag placement slot 101 and an infusion bag placement slot 102 are provided. The reinfusion bag placement slot 101 and the infusion bag placement slot 102 are connected. A cell reinfusion bag 2 is placed in the reinfusion bag placement slot 101, and a cell infusion bag 4 is placed in the infusion bag placement slot 102. The cell infusion bag 4 is connected to the cell infusion bag 4 through a filter tube 3. A notch 103 is provided on the side wall of the housing 1 away from the transport placement slot. A connector 7 for connecting to the infusion tube is provided on the cell infusion bag 4. The connector 7 is located outside the notch 103.

[0024] In this embodiment, a transparent cover 9 is provided at the upper end of the box body 1. The transparent cover 9 is hinged to one side wall of the box body 1 by a hinge and connected to the other side wall of the box body 1 by a magnet, so as to facilitate opening and closing.

[0025] The casing 1 is made of materials with good thermal conductivity to ensure the cold environment required for cell reinfusion bag 2 during transportation.

[0026] In this embodiment, as Figures 3-6 As shown, the filter tube 3 includes an upper pipe 301 and a lower pipe 303. The upper pipe 301 is connected to the lower pipe 303 via a tear-off ring 302. A partition plug 307 is provided inside the upper pipe 301. The inner wall of the tear-off ring 302 is provided with an inclined surface 3021 along its circumference. The partition plug 307... The lower end of the sealing plug 307 is fitted with the inclined surface 3021 to seal the upper pipe 301. A limiting cylinder 304 is provided on the outside of the sealing plug 307. The lower end of the limiting cylinder 304 is located on the upper end surface of the tear ring 302. A frustum 313 is provided in the lower pipe 303 along its circumferential direction. The frustum 313 divides the lower pipe 303 into a connecting cavity 314 and a filtering cavity 315. Multiple coaxial limiting grooves are provided in the connecting cavity 314 and the inner wall of the upper pipe 301 along its circumferential direction. Multiple limiting strips 305 that cooperate with the limiting grooves are provided in the outer wall of the limiting cylinder 304 along its circumferential direction. At least two limiting blocks 306 are provided in the inner wall of the limiting cylinder 304 along its circumferential direction. The limiting blocks 306 are fitted with the upper end of the sealing plug 307.

[0027] The lower end of the filter chamber 315 is connected to the cell infusion bag 4. The filter chamber 315 is equipped with a filter bucket 316 and a support plate 319. The support plate 319 is located below the filter bucket 316 and is connected to the inner wall of the filter chamber 315. The upper end of the filter bucket 316 abuts against the lower end face of the frustum 313. The filter bucket 316 is equipped with a movable plug 317 and a first compression spring 318. The lower end of the first compression spring 318 is connected to the bottom wall of the filter bucket 316, and its upper end is connected to the lower end of the movable plug 317. The upper end of the movable plug 317 is in contact with the inner wall of the frustum 313. The top of the upper end of the movable plug 317 is provided with an adapter groove. The bottom of the lower end of the partition plug 307 is located in the adapter groove. The side wall of the filter bucket 316 is provided with a plurality of primary filtration holes 3161 along its circumference. The support plate 319 is provided with fine filtration holes 3191.

[0028] In this embodiment, after the tear-off ring 302 is removed, the upper pipe 301 and the lower pipe 303 are connected by a limiting cylinder 304. However, to prevent the limiting cylinder 304 from sliding up and down inside the upper pipe 301 and the lower pipe 303, a first positioning groove 308 is provided between two adjacent limiting strips 305 on the outer wall of the limiting cylinder 304. A groove is provided on the inner wall of the upper pipe 301, and a first positioning element coaxial with the first positioning groove 308 is provided in the groove. A groove is also provided on the outer wall of the limiting cylinder 304 between two adjacent limiting strips 305, and a second positioning element is provided in the groove. A second positioning groove 309 coaxial with the second positioning element is provided on the inner wall of the connecting cavity 314.

[0029] The first positioning component and the second positioning component have the same structure, both including a telescopic rod 310 and a second compression spring 311. One end of the telescopic rod 310 is connected to the inner wall of the groove, and the other end is provided with a positioning block 312. The second compression spring 311 is sleeved on the outside of the telescopic rod 310, and one end is connected to the fixing block, and the other end is connected to the inner wall of the groove.

[0030] During the process of filtering cells from the cell reinfusion bag 2 into the cell infusion bag 4, the tear ring 302 on the filter tube 3 is manually torn off. The limiting cylinder 304 and the septum plug 307 lose their support and fall into the lower pipe 303 under gravity. The limiting cylinder 304 stops falling after its bottom contacts the frustum 313. The positioning block 312, under the action of the second compression spring 311, is pressed into the positioning groove to fix the limiting cylinder 304. Meanwhile, the septum plug 307 continues to fall, pressing the movable plug 317 down, thus exposing the primary filtration hole 3161 on the side wall of the filter bucket 316. The cells then undergo the first stage of filtration through the primary filtration hole 3161, and then undergo the second stage of filtration through the fine filtration hole 3191 on the support plate 319. The pore size of the fine filtration hole 3191 is 50-100 μm. This can filter out cell clusters or cell clumps.

[0031] Example 2 This embodiment, based on embodiment 1, adds an electrically oscillating structure, specifically as follows: Figures 7-9 As shown.

[0032] In this embodiment, each of the two symmetrical sidewalls of the infusion bag placement slot 102 has a movable cavity 104. A turntable 15 is installed within each movable cavity 104. A rotating shaft 14 is installed on the end face of the turntable 15 away from the infusion bag placement slot 102. The rotating shaft 14 is connected to a drive motor 11 via a coupling 13 and a reducer 12. The drive motor 11, coupling 13, and reducer 12 are housed in a mounting box 8 on the outer wall of the housing 1. The turntable 15 is located near the infusion bag. One end face of the placement slot 102 is provided with an inclined surface 15013021. The movable cavity 104 is also provided with a squeezing rod 16. One end of the squeezing rod 16 is in contact with the inclined surface 15013021, and the other end is located in a T-shaped guide groove 105 provided on the inner wall of the movable cavity 104. The T-shaped groove is connected to the infusion bag placement slot 102 through a receiving groove 106. The other end of the squeezing rod 16 is provided with a squeezing block 17, which is located in the receiving groove 106.

[0033] The outer wall of the extrusion rod 16 is provided with a third compression spring 19. One end of the third spring is connected to the inner wall of the T-shaped guide groove 105, and the other end is connected to the inner end face of the extrusion block 17. The outer end face of the extrusion block 17 is provided with a plurality of extrusion protrusions 18.

[0034] In this embodiment, two extruders are symmetrically arranged along the turntable 15, and the two extruders alternately extrude the cell infusion bag 4.

[0035] When it is necessary to shake the cell infusion bag 4, the power is turned on and the drive motor 11 is started to drive the turntable 15 to rotate. The inclined surface 15013021 moves in a circular motion with the drum, which regularly pushes the squeezing rod 16 to move towards the cell infusion bag 4. The squeezing protrusion 18 then squeezes the cell infusion bag 4. Since the squeezing parts on both sides of the cell infusion bag 4 are driven synchronously, it can simulate the hands of medical staff to achieve the purpose of shaking the cells.

[0036] Example 3 In this embodiment, the cell reinfusion bag 2 is also provided with a cell injection interface 5, and the cell infusion bag 4 is also provided with a bidirectional control switch 6. The bidirectional control switch 6 includes a fixed connector 601 and a movable connector 602. The fixed connector 601 is connected to the cell infusion bag 4, and the movable connector 602 is threadedly connected to the fixed connector 601.

[0037] Specifically, such as Figures 10-11As shown, a flow-limiting cavity 603 is provided at one end of the fixed joint 601 near the movable joint 602. A coaxial guide cylinder 604 and a movable cylinder 605 are disposed within the flow-limiting cavity 603. The inner end face of the guide cylinder 604 is fixedly connected to the inner end wall of the flow-limiting cavity 603. A guide hole 606 is provided along the circumference of the guide cylinder 604. The movable cylinder 605 is located inside the guide cylinder 604 and has a convection hole 607 provided along its circumference. Multiple mounting grooves 608 are provided along the circumference of the inner end wall of the flow-limiting cavity 603. Each mounting groove 608... Each component is equipped with a fourth compression spring 609. One end of the fourth compression spring 609 is connected to the inner end wall of the mounting groove 608, and the other end is connected to the inner end face of the movable cylinder 605. The movable joint 602 is equipped with a disc 610 inside. The disc 610 is connected to the inner wall of the movable joint 602 by a support plate 611. An adjusting cylinder 612 is provided at one end of the disc 610 near the fixed joint 601. The free end of the adjusting cylinder 612 is located inside the guide cylinder 604.

[0038] When sampling is required, the movable joint 602 is rotated towards the fixed joint 601. The adjusting cylinder 612 squeezes the movable cylinder 605 into the limiting cavity, aligning the convection hole 607 and the guide hole 606. The fourth compression spring 609 is compressed into the mounting groove 608. Cells sequentially pass through the convection hole 607, the guide hole 606, and the limiting cavity into the movable joint 602, thus achieving sampling. The operation is simple and highly safe. After sampling is completed, the movable joint 602 is rotated outward, the movable cylinder 605 loses its compression, and resets under the action of the fourth compression spring 609. The convection hole 607 and the guide hole 606 are misaligned, thus achieving a seal.

[0039] In this embodiment, the manufacturer can directly connect a sampling bottle or sampling bag to the movable connector 602, typically using a threaded connection. During transportation, it coexists with the cell reinfusion belt 2 and the cell infusion bag 4. When sampling is required, simply rotate the movable connector 602, and the cells in the cell infusion bag 4 will flow into the sampling bottle or sampling bag. After sampling, rotate the movable connector 602 in the opposite direction to seal the cell infusion bag 4, allowing the sampling bottle or sampling bag to be removed for testing. The cell infusion bag 4 is kept sealed throughout the process to prevent infection.

[0040] The above description is merely a preferred embodiment of the present invention and does not constitute any limitation on the present invention. Any simple modifications, alterations, and equivalent changes made to the above embodiments based on the technical essence of the invention shall still fall within the protection scope of the technical solution of the present invention.

Claims

1. An integrated multifunctional cell reinfusion device, characterized in that, include: The box body is provided with a cell reinfusion bag placement slot and an infusion bag placement slot, which are connected. A cell reinfusion bag is placed in the cell reinfusion bag placement slot, and a cell infusion bag is placed in the infusion bag placement slot. A notch is provided on the side wall of the box body away from the transport placement slot. A connector for connecting to the infusion tube is provided on the cell infusion bag, which is located outside the notch. Movable cavities are provided inside the two symmetrical side walls of the infusion bag placement slot. A cell injection interface is also provided on the cell reinfusion bag. A filter tube connects the cell reinfusion bag to the cell infusion bag. The filter tube includes an upper tube and a lower tube. The upper tube is connected to the lower tube via a tear-off ring. A sealing plug is installed inside the upper tube. The inner wall of the tear-off ring has a bevel along its circumference. The lower end of the sealing plug fits against the bevel to seal the upper tube. A limiting cylinder is installed outside the sealing plug, with its lower end located on the upper surface of the tear-off ring. A frustum is installed inside the lower tube along its circumference, dividing the lower tube into a connecting chamber and a filtering chamber. Multiple coaxial limiting grooves are provided on the inner walls of the connecting chamber and the upper tube along their circumference. Multiple limiting grooves that mate with the limiting grooves are provided on the outer wall of the limiting cylinder along its circumference. The limiting cylinder has at least two limiting blocks arranged along its circumference inside. The limiting blocks are attached to the upper end of the diaphragm plug. When the cells in the cell reinfusion bag are filtered into the cell infusion bag, the tear ring on the filter tube is manually torn off. The limiting cylinder and the diaphragm plug lose their support and fall into the pipeline under the action of gravity. The limiting cylinder stops falling after the bottom contacts the frustum. The positioning block is squeezed into the positioning groove under the action of the second compression spring to fix the limiting cylinder. The diaphragm plug continues to fall and squeezes the movable plug down, thereby exposing the primary filtration hole on the side wall of the filter bucket. The cells then undergo the first filtration through the primary filtration hole and then the second filtration through the fine filtration hole on the support plate, filtering out cell clusters or cell clumps. A turntable is disposed within the movable cavity. A rotating shaft is located on the end face of the turntable away from the infusion bag placement slot. The rotating shaft is connected to a drive motor via a coupling and a reducer. The drive motor, coupling, and reducer are housed in a mounting box on the outer wall of the housing. An inclined surface is provided on the end face of the turntable near the infusion bag placement slot. A squeezing rod is also disposed within the movable cavity. One end of the squeezing rod is in contact with the inclined surface, and the other end is located within a T-shaped guide groove on the inner wall of the movable cavity. The T-shaped groove is connected to the infusion bag placement slot via a receiving groove. A squeezing block is provided at the other end of the squeezing rod, located within the receiving groove. A third compression spring is provided on the outer wall of the squeezing rod. One end of the third spring is connected to the inner wall of the T-shaped guide groove, and the other end is connected to the inner end face of the squeezing block. Multiple squeezing protrusions are provided on the outer end face of the squeezing block. A bidirectional control switch is disposed on the cell infusion bag. The bidirectional control switch includes a fixed connector and a movable connector. The fixed connector is connected to the cell infusion bag, and the movable connector is threadedly connected to the fixed connector.

2. The integrated multifunctional cell reinfusion device according to claim 1, characterized in that, The enclosure is made of a material with good thermal conductivity.

3. The integrated multifunctional cell reinfusion device according to claim 1, characterized in that, The upper end of the box is provided with a transparent cover, which is hinged to one side wall of the box via a hinge and connected to the other side wall of the box via a magnet.

4. The integrated multifunctional cell reinfusion device according to claim 1, characterized in that, The lower end of the filtration chamber is connected to the cell infusion bag. A filter bucket and a support plate are provided inside the filtration chamber. The support plate is located below the filter bucket and connected to the inner wall of the filtration chamber. The upper end of the filter bucket abuts against the lower end face of the frustum. A movable plug and a first compression spring are provided inside the filter bucket. The lower end of the first compression spring is connected to the bottom wall of the filter bucket, and its upper end is connected to the lower end of the movable plug. The upper end of the movable plug is in contact with the inner wall of the frustum. An adapter groove is provided at the top of the upper end of the movable plug. The bottom of the lower end of the partition plug is located in the adapter groove. Multiple primary filtration holes are provided along the circumference of the side wall of the filter bucket. Fine filtration holes are provided on the support plate.

5. The integrated multifunctional cell reinfusion device according to claim 4, characterized in that, A first positioning groove is provided between two adjacent limiting strips. A groove is provided on the inner wall of the upper pipe. A first positioning element coaxial with the first positioning groove is provided in the groove. A groove is also provided on the outer wall of the limiting cylinder between two adjacent limiting strips. A second positioning element is provided in the groove. A second positioning groove coaxial with the second positioning element is provided on the inner wall of the connecting cavity.

6. The integrated multifunctional cell reinfusion device according to claim 5, characterized in that, The first positioning element and the second positioning element have the same structure, both including a telescopic rod and a second compression spring. One end of the telescopic rod is connected to the inner wall of the groove, and the other end is provided with a positioning block. The second compression spring is sleeved on the outside of the telescopic rod, and one end is connected to the fixing block, and the other end is connected to the inner wall of the groove.

7. The integrated multifunctional cell reinfusion device according to claim 4, characterized in that, The pore size of the fine filter is 50-100μm.

8. The integrated multifunctional cell reinfusion device according to claim 1, characterized in that, A flow-limiting cavity is provided at one end of the fixed joint near the movable joint. A coaxial guide tube and a movable tube are arranged within the flow-limiting cavity. The inner end face of the guide tube is fixedly connected to the inner end wall of the flow-limiting cavity. A guide hole is provided along the circumference of the guide tube. The movable tube is located inside the guide tube and has a convection hole along its circumference. Multiple mounting slots are provided along the circumference of the inner end wall of the flow-limiting cavity. A fourth compression spring is installed in each mounting slot. One end of the fourth compression spring is connected to the inner end wall of the mounting slot, and the other end is connected to the inner end face of the movable tube. A disc is provided inside the movable joint. The four... The disc is connected to the inner wall of the movable joint via a support plate. An adjusting cylinder is provided at one end of the disc near the fixed joint. The free end of the adjusting cylinder is located inside the guide cylinder. When sampling is required, the movable joint is rotated towards the fixed joint, and the adjusting cylinder squeezes the movable cylinder into the limiting cavity. The convection hole and the guide hole are aligned, and the fourth compression spring is compressed into the mounting groove. Cells pass through the convection hole, the guide hole, and the limiting cavity in sequence to enter the movable joint, thereby achieving sampling. After sampling is completed, the movable joint is rotated outward, the movable cylinder loses its compression, and it resets under the action of the fourth compression spring. The convection hole and the guide hole are misaligned, thus achieving a seal.

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