Bionic vein type microfluidic skin sweat dynamic collection device

Abstract

The invention relates to the field of wearable health monitoring equipment, and discloses a bionic vein type micro-fluidic skin sweat dynamic collection device, which comprises a skin-friendly fitting layer of a flexible sheet structure, the edge of the skin-friendly fitting layer is provided with an annular sticking layer; the sweat permeation holes are formed in the skin-friendly attaching layer in a penetrating manner; the flow guide layer is arranged on the upper surface of the skin-friendly fitting layer; a bionic vein graded flow guide structure is adopted, branch veins, secondary veins and a main vein flow guide channel form an efficient transmission network, a vein moisture convergence mechanism is simulated, and the one-to-one correspondence design of the branch veins and sweat permeation holes is matched, so that sweat secreted by skin quickly and accurately enters the channels, dispersion and loss are avoided, and the skin quality is improved. The differential design of the large diameter and the small diameter of the conical connecting pipe is combined with the 30-60-degree spiral protrusion structure on the inner wall of the secondary vein, sweat flowing resistance is reduced, transmission is accelerated, meanwhile, accumulated liquid and residues in a channel are avoided, and it is guaranteed that the collecting process is efficient and smooth.

Description

Technical Field

[0001] This application relates to the field of wearable health monitoring devices, and in particular to a biomimetic leaf vein-type microfluidic dynamic collection device for skin sweat. Background Technology

[0002] Sweat, as one of the body's essential fluids, contains abundant biomarkers such as proteins, hormones, electrolytes, and metabolites, and its compositional changes are closely related to human health. Compared to invasive monitoring methods such as blood tests, non-invasive sweat-based monitoring technologies offer advantages such as ease of operation, continuous monitoring, and no physiological pain, and have broad application prospects in areas such as sports health management, early disease screening, and clinical monitoring.

[0003] Microfluidics, with its miniaturization, integration, and low sample consumption, has become a core technology supporting sweat collection and detection. Currently available microfluidic sweat collection devices mostly employ traditional linear or grid-type channel structures, which suffer from low sweat collection efficiency, poor flow guidance, and the tendency for sweat backflow or mixing of old and new sweat. For example, the channel design of some devices fails to adequately adapt to the distribution characteristics of sweat secretion on the skin surface, leading to localized sweat accumulation and hindering timely flow. Furthermore, significant resistance exists at channel connections in some devices, affecting the dynamic and continuous collection of sweat, causing already collected sweat to mix with newly secreted sweat, thus reducing the accuracy of subsequent detection. Summary of the Invention

[0004] To address the above issues, this application provides a biomimetic leaf vein-based microfluidic dynamic collection device for skin sweat.

[0005] The biomimetic leaf vein-type microfluidic dynamic skin sweat collection device provided in this application adopts the following technical solution: A biomimetic leaf vein-based microfluidic dynamic sweat collection device includes: a skin-friendly adhesive layer, which is a flexible sheet structure with an annular adhesive layer at its edge; several sweat permeation holes, which are formed through the skin-friendly adhesive layer; a flow guiding layer, which is disposed on the upper surface of the skin-friendly adhesive layer and includes a main leaf vein flow guiding channel, a secondary leaf vein flow guiding channel, and several branch leaf vein flow guiding channels; a protective shell, which covers the upper surface of the flow guiding layer and has through holes corresponding to the positions of the several branch leaf vein flow guiding channels; and a sweat storage tank, which is sealed to the main leaf vein flow guiding channel through a conical connecting tube.

[0006] Preferably, it also includes a detection interface, which is installed on the protective shell, with one end communicating with the inside of the sweat storage tank and the other end being sealed to an external micro negative pressure pump.

[0007] Preferably, the branch vein guiding channel corresponds to and is connected to the sweat penetration hole through the through hole. The end of the branch vein guiding channel close to the secondary vein guiding channel intersects with the secondary vein guiding channel. One end of the tapered connecting tube is connected to the main vein guiding channel, and the other end is connected to the secondary vein guiding channel.

[0008] Preferably, the large-diameter end of the tapered connecting tube is connected to the main leaf vein guiding channel, and the small-diameter end is connected to the secondary leaf vein guiding channel.

[0009] Preferably, the skin-friendly adhesive layer is made of medical-grade silicone material, and the sweat permeation pores are circular pores, with the number and distribution of the sweat permeation pores corresponding one-to-one with the branch vein flow channels.

[0010] Preferably, the inner wall of the secondary leaf vein guiding channel is provided with a spiral protrusion structure, and the spiral angle of the spiral protrusion structure is 30°-60°.

[0011] Preferably, the adhesive layer is a medical pressure-sensitive adhesive, and the outer edge of the adhesive layer is flush with the outer edge of the skin-friendly adhesive layer.

[0012] In summary, this application includes the following beneficial technical effects: 1. Adopting a biomimetic leaf vein hierarchical flow guiding structure, the branch leaf veins, secondary leaf veins and main leaf vein flow guiding channels form an efficient transmission network, simulating the water gathering mechanism of leaf veins. With the one-to-one correspondence design between branch leaf veins and sweat permeation pores, the sweat secreted by the skin can quickly and accurately enter the channel, avoiding dispersion and loss. The differentiated design of the large and small diameter of the tapered connecting tube, combined with the 30°-60° spiral protrusion structure on the inner wall of the secondary leaf vein, reduces the flow resistance of sweat, accelerates the transmission, and at the same time avoids the accumulation of liquid and residue in the channel, ensuring that the collection process is efficient and smooth. 2. The skin-friendly adhesive layer is made of medical-grade silicone, and the adhesive layer is made of medical-grade pressure-sensitive adhesive. Both have excellent biocompatibility and strong flexibility, which can not only fit closely to the skin without irritation, but also ensure stable fixation of the device. It can be removed without damaging the skin. The outer edges of the adhesive layer and the skin-friendly adhesive layer are flush. With the sealing coverage of the protective shell, it can effectively prevent sweat leakage and the entry of external air, ensuring a clean collection environment. Attached Figure Description

[0013] Figure 1 This is a structural front view of an embodiment of the application; Figure 2 This is a rear view of the structure of an embodiment of the application; Figure 3 This is a schematic diagram of the flow guide layer in the embodiment of the application; Figure 4 This is a cross-sectional view of the flow guide layer in the embodiment of the application.

[0014] Explanation of reference numerals in the attached diagram: 1. Skin-friendly adhesive layer; 2. Adhesive layer; 3. Sweat permeation pores; 4. Protective shell; 5. Detection interface; 6. Branch vein guide channel; 7. Secondary vein guide channel; 8. Main vein guide channel; 9. Sweat storage tank; 10. Spiral protrusion structure; 11. Through hole; 12. Tapered connecting pipe. Detailed Implementation

[0015] The following is in conjunction with the appendix Figure 1-4 This application will be described in further detail.

[0016] This application discloses a biomimetic leaf vein-inspired microfluidic dynamic skin sweat collection device, referring to... Figures 1-2 The device includes a skin-friendly adhesive layer 1, which is a flexible medical silicone sheet. Its edges are coated with a ring-shaped medical pressure-sensitive adhesive as an adhesive layer 2, used to tightly adhere to the skin and fix the device. The adhesive layer 2 is a medical pressure-sensitive adhesive with good adhesion and skin compatibility, which can stably fix the device on the skin surface and will not damage the skin when it is removed. The outer edge of the adhesive layer 2 is flush with the outer edge of the skin-friendly adhesive layer 1 to ensure the airtightness of the device and prevent external air from entering and affecting the negative pressure environment, while also preventing sweat leakage. Several circular sweat permeation holes 3 are evenly distributed on the skin-friendly adhesive layer 1. The number of sweat permeation holes 3 is set according to the actual collection needs and is used to guide sweat from the skin surface into the device.

[0017] Reference Figure 1 and Figure 3 The flow-guiding layer adopts a biomimetic leaf vein structure design and is fixed on the upper surface of the skin-friendly adhesive layer 1. The flow-guiding layer includes one main leaf vein flow-guiding channel 8, one secondary leaf vein flow-guiding channel 7, and several left and right symmetrical branch leaf vein flow-guiding channels 6. The positions of the branch leaf vein flow-guiding channels 6 are consistent with the positions of the sweat penetration holes 3 and correspond one-to-one. The secondary leaf vein flow-guiding channels 7 intersect with each branch leaf vein flow-guiding channel 6. All secondary leaf vein flow-guiding channels 7 are connected to the main leaf vein flow-guiding channel 8 through a tapered connecting tube 12. The large-diameter end of the tapered connecting tube 12 is sealed and bonded to the main leaf vein flow-guiding channel 8, and the small-diameter end is sealed and bonded to the secondary leaf vein flow-guiding channels 7, so as to realize the graded collection and efficient transmission of sweat.

[0018] The protective shell 4 is made of hard plastic and covers the upper surface of the flow-guiding layer. It is sealed to the edge of the skin-friendly layer 1. The protective shell 4 has an array of through holes 11 corresponding to the position of each branch vein flow-guiding channel 6. The branch vein flow-guiding channel 6 corresponds to and is connected to the sweat penetration hole 3 through the through holes 11, ensuring that the sweat penetrating from the skin can accurately enter the branch vein flow-guiding channel 6, forming a hierarchical flow-guiding structure of branch-secondary-main vein, simulating the water transport mechanism of leaf veins and improving the sweat collection efficiency.

[0019] Reference Figures 3-4The inner wall of the secondary leaf vein guiding channel 7 is integrally formed with a spiral protrusion structure 10. The spiral angle of the spiral protrusion structure 10 is 45°. The spiral protrusion structure 10 can guide sweat to form a spiral flow in the secondary leaf vein guiding channel 7, reduce the frictional resistance of the tube wall, and at the same time increase the transmission speed of sweat, avoiding sweat residue and evaporation.

[0020] The sweat storage tank 9 is a transparent, sealed tank fixed inside the protective shell 4. Its bottom is sealed to the end of the main vein guide channel 8 through a pipe. The detection interface 5 is a metal interface with a sealing thread, which is installed on the side wall of the protective shell 4. One end extends into the inside of the sweat storage tank 9, and the other end is used to seal the connection pipe of the external micro negative pressure pump. Through the negative pressure environment provided by the micro negative pressure pump, the dynamic and continuous collection of sweat can be realized, avoiding the residue of sweat in the guide channel and improving the collection efficiency.

[0021] The implementation principle of the biomimetic leaf vein-type microfluidic skin sweat dynamic collection device in this application embodiment is as follows: When in use, the skin-friendly adhesive layer 1 is fixed to the sweat secretion area of ​​the skin (such as the forearm, forehead, etc.) through the adhesive layer 2 to ensure that the sweat permeation pores 3 are in close contact with the skin surface; the external micro negative pressure pump is connected to the detection interface 5 through the sealed pipe, and the micro negative pressure pump is started to form a stable negative pressure environment in the sweat storage tank 9 and the guide channel.

[0022] Sweat secreted by the skin enters the branch vein guiding channel 6 through the sweat permeation pores 3 and the through holes 11. Under negative pressure, the sweat flows along the branch vein guiding channel 6 to the secondary vein guiding channel 7. The spiral protrusion structure 10 on the inner wall of the secondary vein guiding channel 7 guides the sweat to form a spiral flow, reducing flow resistance and accelerating sweat transmission. The sweat enters the main vein guiding channel 8 through the conical connecting tube 12 and finally converges into the sweat storage tank 9 for storage.

[0023] Throughout the collection process, a negative pressure environment ensures dynamic and continuous sweat transfer, preventing residue and evaporation. A biomimetic leaf vein-like flow guide structure guarantees collection efficiency, while skin-friendly materials and a sealed design ensure comfort and the integrity of the sweat composition. After collection, turn off the miniature negative pressure pump and disconnect the detection interface 5 from the pump. The sweat sample can then be retrieved from the sweat storage tank 9 for subsequent testing and analysis.

[0024] Finally, the following points should be noted: First, in the description of this application, it should be noted that, unless otherwise specified and limited, the terms "installation", "connection", and "linkage" should be interpreted broadly, and can be mechanical or electrical connections, or internal connections between two components, or direct connections. "Up", "down", "left", "right", etc. are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may change. Secondly: The accompanying drawings of the embodiments disclosed in this invention only involve the structures involved in the embodiments disclosed in this invention. Other structures can refer to the general design. In the absence of conflict, the same embodiment and different embodiments of this invention can be combined with each other. In conclusion, the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

[0025] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A biomimetic leaf vein-inspired microfluidic dynamic sweat collection device, characterized in that, include: The skin-friendly adhesive layer (1) is a flexible sheet structure with an annular adhesive layer (2) at its edge. A plurality of sweat penetration pores (3) are provided and are opened through the skin-friendly adhesive layer (1); A flow guiding layer is disposed on the upper surface of the skin-friendly adhesive layer (1), including a main vein flow guiding channel (8), a secondary vein flow guiding channel (7) and several branch vein flow guiding channels (6). A protective shell (4) is provided on the upper surface of the flow guiding layer. The protective shell (4) has through holes (11) at the positions of several branch vein flow guiding channels (6). The sweat storage tank (9) is sealed to the main vein guide channel (8) via a tapered connecting pipe (12).

2. The biomimetic leaf vein-type microfluidic dynamic skin sweat collection device according to claim 1, characterized in that: It also includes a detection interface (5), which is installed on the protective shell (4), with one end connected to the inside of the sweat storage tank (9) and the other end sealed to the external micro negative pressure pump.

3. The biomimetic leaf vein-type microfluidic dynamic skin sweat collection device according to claim 1, characterized in that: The branch vein flow channel (6) is connected to the sweat penetration hole (3) through the through hole (11). The branch vein flow channel (6) is close to the secondary vein flow channel (7) and intersects with the secondary vein flow channel (7). One end of the tapered connecting tube (12) is connected to the main vein flow channel (8), and the other end is connected to the secondary vein flow channel (7).

4. The biomimetic leaf vein-type microfluidic dynamic skin sweat collection device according to claim 3, characterized in that: The large-diameter end of the tapered connecting pipe (12) is connected to the main leaf vein guiding channel (8), and the small-diameter end is connected to the secondary leaf vein guiding channel (7).

5. The biomimetic leaf vein-type microfluidic dynamic skin sweat collection device according to claim 1, characterized in that: The skin-friendly adhesive layer (1) is made of medical silicone material. The sweat penetration holes (3) are circular holes, and the number and distribution of the sweat penetration holes (3) correspond one-to-one with the branch vein guide channels (6).

6. The biomimetic leaf vein-type microfluidic dynamic skin sweat collection device according to claim 1, characterized in that: The inner wall of the secondary leaf vein guiding channel (7) is provided with a spiral protrusion structure (10), and the spiral angle of the spiral protrusion structure (10) is 30°-60°.

7. The biomimetic leaf vein-type microfluidic dynamic skin sweat collection device according to claim 1, characterized in that: The adhesive layer (2) is a medical pressure-sensitive adhesive, and the outer edge of the adhesive layer (2) is flush with the outer edge of the skin-friendly adhesive layer (1).

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