Freeze-dried powder base containing bionic sebum composition and preparation method of freeze-dried powder base

Abstract

The invention discloses a freeze-dried powder base containing a bionic sebum composition and a preparation method of the freeze-dried powder base, and belongs to the technical field of cosmetics. The freeze-dried powder substrate comprises a freeze-dried powder phase and a liquid matrix phase in a weight ratio of 1: (3-6), the freeze-dried powder phase is composed of a phase A, a phase B, a phase C and a phase D, the phase C contains a bionic sebum composition, and the composition is formed by compounding ceramide, a phytosterol ester compound and squalane according to a specific weight ratio; the liquid matrix phase comprises a water phase and an oil phase, and the components of the phases are proportioned according to specific weight percentages. Through the cooperation of the bionic sebum composition and the freeze-drying process, the foundation can quickly reconstruct a human sebum-like film, skin cutin gaps are filled, and the technical problems that a traditional foundation make-up is poor in skin attaching performance, prone to powder clamping and short in make-up lasting time are solved; and meanwhile, the freeze-drying process can stabilize functional components which are easy to inactivate at high temperature, so that the function of combining base makeup and care is realized.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a freeze-dried foundation containing a biomimetic sebum composition and its preparation method. Background Technology

[0002] Foundation, as a commonly used base makeup cosmetic, has the core functions of evening out skin tone and concealing blemishes, while also needing good skin adhesion, staying power, and safety. As consumers' demands for cosmetics have evolved, traditional foundations have gradually revealed many problems. Traditional liquid foundations are mostly in lotion or cream form, often struggling to achieve a balance between long-lasting wear, skin adhesion, and a smooth finish. On one hand, in traditional formulas, the powder is directly dispersed in the oil-water phase, which can easily lead to powder settling and clumping during long-term storage, resulting in a heavy, cakey, and less refined makeup look. On the other hand, active ingredients in liquid systems are easily affected by moisture, oxygen, and temperature, causing degradation, deactivation, or discoloration, leading to poor product stability and difficulty in maintaining efficacy.

[0003] In recent years, freeze-drying technology has been applied in the cosmetics industry to improve product stability. However, existing technologies mostly apply freeze-drying to single serum or mask products, or simply mix powders and excipients and freeze-dry them, failing to address the core issue of poor integration between powder and skin in foundation products. These products lack simulation of the skin barrier structure and cannot achieve seamless adhesion between the foundation and the stratum corneum, thus exhibiting significant shortcomings in terms of makeup longevity, anti-oxidation and dullness, and skin-nourishing effects. Chinese invention patent application CN120771068A discloses a freeze-dried foundation and its preparation method, but it focuses on smooth skin feel and basic moisturizing, lacking the function of reconstructing a human-like sebum membrane. It cannot fundamentally solve the problems of insufficient skin adhesion and caking, and its repair and adaptability to the skin barrier are weak.

[0004] Therefore, developing a foundation product that combines biomimetic skin structure with powder stabilization technology to achieve a smooth, skin-adhering finish, long-lasting makeup, and stable high-activity ingredients has significant market value and technological importance. Summary of the Invention

[0005] The purpose of this invention is to overcome the shortcomings of the prior art and provide a freeze-dried foundation containing a biomimetic sebum composition and its preparation method, thereby solving the technical problems of traditional foundations such as poor skin adhesion, easy caking, short makeup duration, and unstable active ingredients.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: A freeze-dried foundation containing a biomimetic sebum composition comprises a freeze-dried powder phase and a liquid matrix phase, wherein the weight ratio of the freeze-dried powder phase to the liquid matrix phase is 1:(3-6). The freeze-dried powder phase includes phases A, B, C, and D. By weight percentage, phase A comprises 20-45% colorant and 0.5-10% skin feel modifier; phase B comprises 0.1-5% excipient and the balance being water; phase C comprises 1-5% primary emulsifier, 10-30% oily solvent, and 0.1-2% biomimetic sebum composition; and phase D comprises 0.001-10% active ingredient and 0.2-0.6% primary preservative. The biomimetic sebum composition is composed of ceramide, phytosterol esters and squalane in a weight ratio of (0.05-0.15):(2.5-3.5):(95.5-98.5).

[0007] This application utilizes a blend of ceramides, phytosterol esters, and squalane to mimic the key structures and functions of a healthy skin barrier. These three components work synergistically in specific proportions to rapidly reconstruct a continuous, skin-friendly biomimetic film at the skin-powder interface during makeup application. This film reduces the interfacial tension between the powder and the skin, transforming the foundation's application from mechanical adhesion to biomimetic fusion, resulting in unprecedented skin-feel and smoothness. Simultaneously, this biomimetic film partially mimics the skin barrier's water-locking and isolating functions, effectively reducing internal moisture loss and the erosion of makeup by external sebum and sweat, thereby comprehensively improving makeup longevity, anti-dullness properties, and barrier-improving effects. This design fundamentally solves the core problem of poor skin compatibility in traditional foundations.

[0008] The liquid matrix phase comprises an aqueous phase and an oil phase. By weight percentage, the aqueous phase comprises 12-18% polyol humectant, 0.5-2% inorganic salt, 0.6-1.6% secondary preservative, and the balance being water; the oil phase comprises 15-25% volatile oils, 3-8% non-volatile oils, 0.5-2% secondary emulsifier, 1-2% film-forming agent, and 0.1-0.5% thickener.

[0009] Optionally, the skin feel modifier comprises a vinyl polydimethylsiloxane / polymethylsiloxane sesquioxane crosslinked polymer.

[0010] This application's skin feel modifier uses a vinyl polydimethylsiloxane / polymethylsiloxane silsesquioxane crosslinked polymer. During use, when the lyophilized powder is mixed with a liquid matrix, the crosslinked network of this polymer rapidly absorbs oil and swells moderately, forming an interface layer on the powder surface with moderate adhesion and elasticity. This interface layer significantly improves the dispersion efficiency and stability of the powder in the serum system, ensuring it can be quickly and evenly spread on the skin, thus avoiding clumping or uneven dispersion.

[0011] Optionally, the colorant includes titanium dioxide and iron oxide, wherein the mass ratio of titanium dioxide to iron oxide is (20-40):(1-5).

[0012] Optionally, the excipients include at least one of mannitol and trehalose.

[0013] Optionally, the first emulsifier includes at least one of cetyl PEG / PPG-10 / 1 polydimethylsiloxane, PEG-10 polydimethylsiloxane, lauryl PEG-10 tris(trimethoxy)silylethyl polydimethylsiloxane, or lauryl PEG-9 polydimethylsiloxane.

[0014] Optionally, the oily solvent is at least one selected from cyclopentamethoxysiloxane, polydimethylsiloxane, isononyl isononanoate, isododecane, or isohexadecane. Optionally, the active ingredient is ergothioneine or ascorbic acid.

[0015] Optionally, the first preservative includes at least one of 1,2-hexanediol, ethylhexylglycerin, or octyl glycol.

[0016] The present invention also provides a method for preparing the above-mentioned freeze-dried foundation containing a biomimetic sebum composition, the method comprising the preparation of a freeze-dried powder phase and the preparation of a liquid matrix phase; The preparation of the lyophilized powder phase includes the following steps: (1) Disperse the A-phase raw material evenly in a pulverizer to obtain a mixture of A-phase; (2) Mix the B-phase raw material, C-phase raw material and D-phase raw material evenly to obtain a B-phase mixture, a C-phase mixture and a D-phase mixture; (3) Add the B-phase mixture and the D-phase mixture to the C-phase mixture, homogenize and emulsify to obtain an emulsified slurry; (4) Add the A phase mixture to the emulsion slurry and stir evenly to obtain the slurry to be freeze-dried; (5) The slurry to be freeze-dried is freeze-dried, dried and pulverized to obtain the freeze-dried powder phase; The preparation of the liquid matrix phase includes the following steps: (1) Mix the aqueous raw materials and heat them to 70-90℃ to obtain an aqueous mixture; (2) After homogenizing the oil phase raw material, heat it to 70-90℃ to obtain an oil phase mixture; (3) Add the aqueous phase mixture to the oil phase mixture and homogenize for 1-2 min to obtain the liquid matrix phase.

[0017] When using, mix the lyophilized powder phase and the liquid matrix phase.

[0018] Beneficial effects 1. The biomimetic sebum composition of the present invention is composed of ceramide, phytosterol esters and squalane in a weight ratio of (0.05-0.15):(2.5-3.5):(95.5-98.5). Ceramide can fill the gaps between skin keratinocytes and strengthen the skin barrier; phytosterol esters regulate the fluidity of the sebum film; squalane simulates the natural lipids of the human body. The three are compounded in proportion to quickly reconstruct a human-like sebum film, realize the adhesion of powder to the skin, and solve the problems of poor skin adhesion and easy caking of traditional foundation.

[0019] 2. The freeze-dried powder phase of this invention, after being processed by freeze-drying, can reduce powder agglomeration, making the powder finer, and at the same time effectively stabilizes the active ingredients such as ergothioneine and ascorbic acid that are easily deactivated at high temperatures, thus extending the product's shelf life and efficacy.

[0020] 3. The freeze-dried powder phase and liquid matrix phase of this invention are compounded in a ratio of 1:(3-6), which can ensure the concealing effect and avoid the heavy makeup feeling; the proportion of each phase component is optimized to ensure the stability of the system and improve the spreadability and makeup staying power after makeup application.

[0021] 4. The skin feel modifier and colorant of this invention work together to reduce the graininess of makeup; the combination of volatile and non-volatile oils in the liquid matrix phase provides both a refreshing skin feel and long-lasting makeup performance; the film-forming agent further enhances the stability of the makeup and prevents makeup from fading and darkening. Attached Figure Description

[0022] Figure 1 Partial schematic diagrams of the makeup effect in Example 1 and Comparative Example 1 are shown, where a corresponds to Comparative Example 1 and b corresponds to Example 1.

[0023] Figure 2 The application effect of foundation samples in Example 1 and Comparative Example 1 are shown in the figure, where c corresponds to Example 1 and d corresponds to Comparative Example 1.

[0024] Figure 3 The dispersion test results of Example 1 and Comparative Example 6 are shown in the figure, where e corresponds to Example 1 and f corresponds to Comparative Example 6. Detailed Implementation

[0025] Unless otherwise specified, the experimental methods described in the following embodiments of the present invention are generally performed under conventional conditions or as recommended by the manufacturer. All commonly used chemical reagents used in the embodiments are commercially available products.

[0026] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0027] Example 1 A freeze-dried foundation containing a biomimetic sebum composition, wherein each component is formulated according to the following weight percentages, and the specific parameters are shown in Table 1. The weight ratio of the freeze-dried powder phase to the liquid matrix phase is 1:5.

[0028] Table 1

[0029] The water balance in the lyophilized powder phase is based on the total mass of the lyophilized powder phase; the water balance in the liquid matrix phase is based on the total mass of the liquid matrix phase.

[0030] The second aspect of Embodiment 1 of the present invention provides a method for preparing a freeze-dried foundation containing a biomimetic sebum composition, comprising the following steps: 1. Preparation of lyophilized powder phase: (1) Add the A phase raw material of the formula to the pulverizer and disperse it evenly to obtain the A phase mixture; (2) Mix the raw materials of phase B, phase C and phase D in the formula amount evenly to obtain phase B mixture, phase C mixture and phase D mixture; (3) Add the B phase mixture and the D phase mixture to the C phase mixture, place them in an emulsification pot, and homogenize and emulsify at a speed of 2000 rpm for 5 min to obtain an emulsified slurry.

[0031] (4) Add the A phase mixture to the emulsion slurry and stir at 30 rpm for 5 min to obtain the slurry to be freeze-dried; (5) The slurry to be freeze-dried is placed in a freeze-drying device, pre-frozen at -40℃ for 30 min, and then vacuum freeze-dried for 36 h. After freeze-drying, it is pulverized to obtain the freeze-dried powder phase.

[0032] 2. Preparation of liquid matrix phase: (1) Mix the aqueous raw materials and heat them to 80°C to obtain an aqueous mixture; (2) After homogenizing the oil phase raw material, heat it to 80°C to obtain an oil phase mixture; (3) The aqueous phase mixture was slowly added to the oil phase mixture, homogenized at 2000 rpm for 1.5 min, and cooled to room temperature to obtain the liquid matrix phase; 3. When using, simply mix the freeze-dried powder phase and the liquid matrix phase at a weight ratio of 1:5 until homogeneous.

[0033] Example 2 The specific implementation method is the same as in Example 1, except that the amount of biomimetic sebum composition added is adjusted to 0.1% by weight percentage, wherein the ceramide is 0.0001%; ​​the phytosterol oleate is 0.003%; and the squalane is 0.0969%.

[0034] Example 3 The specific implementation method is the same as in Example 1, except that the amount of biomimetic sebum composition added is adjusted to 2% by weight percentage, wherein the ceramide is 0.002%; the phytosterol oleate is 0.06%; and the squalane is 1.938%.

[0035] Example 4 The specific implementation method is the same as in Example 1, except that 0.6% by weight of ergothioneine is replaced with 12% by weight of ascorbic acid.

[0036] Example 5 The specific implementation method is the same as in Example 1, except that the freeze-dried powder phase and the liquid matrix phase are mixed at a weight ratio of 1:4.

[0037] Comparative Example 1 The specific implementation method is the same as in Example 1, except that no biomimetic sebum composition component is added.

[0038] Comparative Example 2 The specific implementation method is the same as in Example 1, except that squalane is replaced with white oil.

[0039] Comparative Example 3 The specific implementation method is the same as in Example 1, except that Vitasterol SE ester component was not added.

[0040] Comparative Example 4 Iron oxide yellow, iron oxide red, iron oxide black, and titanium dioxide from Example 1 were mixed evenly according to the proportions in Example 1 and then pulverized uniformly using a pulverizer to obtain an un-lyophilized powder phase. The un-lyophilized powder phase was then mixed with the essence from Example 1 at a ratio of 1:5.

[0041] Comparative Example 5 The specific implementation method is the same as in Example 1, except that: no ergothioneine was added to the freeze-dried powder phase, but 0.1% ergothioneine was added to the aqueous phase of the liquid matrix phase.

[0042] Comparative Example 6 The specific implementation method is the same as in Example 1, except that the vinyl polydimethylsiloxane / polymethylsiloxane sesquioxane crosslinked polymer component was not added to the lyophilized powder phase.

[0043] Comparative Example 7 The specific implementation method is the same as in Example 4, except that no ascorbic acid component is added to the lyophilized powder phase, and 2% ascorbic acid is added to the aqueous phase in the liquid matrix phase.

[0044] Comparative Example 8 Iron oxide yellow, iron oxide red, iron oxide black and titanium dioxide from Example 1 were mixed evenly according to the proportions in Example 1 and then pulverized evenly by a pulverizer to obtain un-freeze-dried powder.

[0045] Performance testing 1. Makeup effect delicate and soft-focus test Using the VISIA skin analyzer, the makeup effect of the freeze-dried foundations from Example 1 and Comparative Example 1 was analyzed after application. The analysis of pore count indicated the fineness of the foundation powder. The finer the powder, the higher the light transmittance, the better the soft-focus effect on pores, and the fewer pores were captured by VISIA. The coarser the powder, the more likely it is to cause creasing and buildup at pores, making the pores more noticeable.

[0046] The makeup effect is delicate and has a soft-focus effect. Figure 1 As can be seen from the figures, in Example 1, the number of pores on the skin surface is significantly reduced, with only a few pores faintly visible. The overall makeup is more even and smooth, demonstrating a good soft-focus coverage effect. In Comparative Example 1, the pores on the skin surface are densely distributed and clearly visible, with some areas showing a grainy texture, indicating that the foundation powder is coarser and cannot effectively cover the pores, resulting in a poor soft-focus effect.

[0047] 2. Antioxidant test Weigh 0.1g of foundation samples from Example 1 and Comparative Example 1 respectively, and apply them evenly to a smooth white plate using a coating machine. The coating effect is shown in the figure. Figure 2 After the sample has been left to stand for 30 minutes, a colorimeter is used to measure and compare its color with that immediately after application to assess the product's oxidation and darkening.

[0048] Test mode: Quality control mode, illumination angle 45 degrees, observation angle 0 degrees; Light source and field of view: Measurements were taken under simulated daylight (D65) light source using a standard 10-degree observer's angle of view; Measurement area: The diameter of the measuring aperture is 20mm.

[0049] L*: Represents brightness (0 = black, 100 = white), the higher the value, the brighter the white; a*: Represents the red-green axis, + indicates a reddish bias, - indicates a greenish bias; b*: Represents the yellow-blue axis, + indicates a yellowish tint, - indicates a bluish tint; ΔE*: Represents the total color difference. The larger the value, the more obvious the color difference from the standard sample.

[0050] YI E313: Yellowness Index. A positive value indicates that the sample is yellow, and the larger the value, the deeper the yellowness; a negative value indicates that the sample is blue.

[0051] The test results are shown in Table 2:

[0052] As shown in Table 2, the color data of Comparative Example 1 did not meet the acceptable standard compared to the initial state, while the colorimeter test data of Example 1 remained within the acceptable range. This result indicates that the foundation with the added biomimetic sebum composition has better application uniformity and can reduce pigment migration caused by oil evaporation, thereby effectively improving the problem of foundation oxidation and dullness.

[0053] 3. Makeup staying power test Makeup staying power test method: Twenty female volunteers who frequently use foundation were selected. The left cheek used freeze-dried foundation from Example 1, and the right cheek used non-freeze-dried foundation from Comparative Example 4. Makeup whiteness was scored 4 hours and 8 hours after application, using a 10-point scale. 9-10 points indicated that the whiteness was basically the same as when first applied, with no dullness or makeup loss, and the makeup was full and even. 7-8 points indicated a slight decrease in whiteness, with only very faint dullness in localized areas (such as the nose and corners of the mouth), no obvious makeup loss, and the overall makeup remained intact. 5-6 points indicated a significant decrease in whiteness, with large areas of the face showing dullness, and slight makeup loss in some areas (such as the T-zone), and the makeup's integrity was average. 3-4 points indicated a significant decrease in whiteness, with severely dull and yellowish skin, an expanded area of ​​makeup loss, poor adhesion between the foundation and skin, and a patchy appearance. 0-2 points indicated almost complete makeup loss, disappearance of whiteness, large areas of foundation peeling off or clumping, and inability to maintain the basic makeup shape. The final score was 20. The average score given by the volunteers. The test results are shown in Table 3: Table 3

[0054] Table 3 shows that there was no significant difference in whiteness between the two products, Example 1 and Comparative Example 4, after 4 hours of makeup application. However, after 8 hours of makeup application, the whiteness retention effect of Example 1 was significantly better than that of Comparative Example 4.

[0055] 4. Stability testing of active ingredients Test Method: Due to its inherent chemical structure, ergothione exhibits significant flavor alteration after prolonged storage in the product, with the alteration becoming more pronounced at higher temperatures. Example 1 and Comparative Example 5 were placed at -18°C, 50°C, and room temperature (25°C) for one month, and the flavor changes were tested. The results are shown in Table 4. Table 4

[0056] As can be seen from Table 4, the freeze-drying process used in Example 1 can significantly improve the long-term stability of the heat-sensitive active ingredient (ergothioneine) in the formulation and effectively prevent the off-odor problem caused by its degradation at high temperatures.

[0057] 5. Transdermal water loss test Test Method: Thirty participants were selected and divided into three groups of 10 each. The left cheek received Example 1, while the right cheek received Comparative Example 1, Example 2, and Example 3 respectively. The treatment lasted 15 days, and changes in transdermal water loss were measured. The results are shown in Table 5. Table 5

[0058] Table 5 shows that Examples 1, 2, and 3, containing the biomimetic sebum composition, all achieved a significant decrease in transdermal water loss of over 10% after 15 days of use; while Comparative Example 1, without the composition, showed a decrease of only 3.5%, which can be considered essentially ineffective or a natural fluctuation. This demonstrates that the biomimetic sebum composition is a key active ingredient for enhancing skin's water-locking ability and improving barrier function.

[0059] 6. Stability testing of active ingredients Test Method: Due to its inherent chemical structure, ascorbic acid can develop an off-flavor in products after prolonged storage, with the rate of flavor change accelerating at higher temperatures. Examples 4 and 7 were placed at -18°C, 50°C, and room temperature (25°C) for one month, and the flavor changes were tested. The test results are shown in Table 6. Table 6

[0060] As shown in Table 6, freeze-drying plays a decisive role in improving the long-term storage stability of active ingredients. Under both accelerated testing (50°C) and actual storage conditions (25°C), freeze-drying effectively prevents the rapid degradation of active ingredients and avoids the development of severe off-odors in the product.

[0061] 7. Particle size test Test method: The lyophilized powder phase of Example 1 and the non-lyophilized powder phase of Comparative Example 8 were used as samples and tested using a Bettersize 2600E laser particle size analyzer. The particle sizes of the lyophilized and non-lyophilized powder phases were compared. The results are shown in Table 7: Table 7

[0062] The test data shows that the freeze-dried powder has a smaller particle size and finer texture compared to single powder particles.

[0063] 8. Powder-laden makeup effect test Test Method: Thirty female volunteers who frequently use foundation makeup were selected and divided into three groups of 10 each. Each group used Example 1, Example 5, and Comparative Example 4, respectively. A professional makeup artist evenly applied 0.8g of the corresponding sample to each volunteer. At 4 hours and 8 hours after makeup application, a three-person professional team independently scored the powderiness using a 10-point scale (7-10 points indicates a flawless makeup with no powderiness; 4-7 points indicates significant powderiness with large areas of the face; 0-4 points indicates almost complete powderiness and patchiness). The average score was then calculated. Results are shown in Table 8. Table 8

[0064] The results showed that after 4 hours, both Examples 1 and 5 had a good makeup finish with no obvious powder settling, and both could meet the needs of daily long-lasting makeup. Comparative Example 4, however, showed obvious powder settling after 4 hours.

[0065] 9. Dispersion test Test method: The corresponding lyophilized powder phase and liquid matrix phase of Example 1 and Comparative Example 6 were weighed respectively, and stirred at 300 rpm for 2 min using an IKA RW20 mixer. The test results are shown in […]. Figure 3 .from Figure 3 It can be seen that Example 1 is completely and uniformly dispersed. Comparative Example 6 also clearly shows smaller particle clusters.

Claims

1. A freeze-dried foundation containing a biomimetic sebum composition, characterized in that, It includes a lyophilized powder phase and a liquid matrix phase, wherein the weight ratio of the lyophilized powder phase to the liquid matrix phase is 1:(3-6). The freeze-dried powder phase includes phases A, B, C, and D. By weight percentage, phase A comprises 20-45% colorant and 0.5-10% skin feel modifier; phase B comprises 0.1-5% excipient and the balance being water; phase C comprises 1-5% primary emulsifier, 10-30% oily solvent, and 0.1-2% biomimetic sebum composition; and phase D comprises 0.001-10% active ingredient and 0.2-0.6% primary preservative. The biomimetic sebum composition is composed of ceramide, phytosterol esters and squalane in a weight ratio of (0.05-0.15):(2.5-3.5):(95.5-98.5).

2. The freeze-dried foundation containing a biomimetic sebum composition according to claim 1, characterized in that, The liquid matrix phase comprises an aqueous phase and an oil phase. By weight percentage, the aqueous phase comprises 12-18% polyol humectant, 0.5-2% inorganic salt, 0.6-1.6% secondary preservative, and the balance being water; the oil phase comprises 15-25% volatile oils, 3-8% non-volatile oils, 0.5-2% secondary emulsifier, 1-2% film-forming agent, and 0.1-0.5% thickener.

3. The freeze-dried foundation containing a biomimetic sebum composition according to claim 1, characterized in that, The skin feel modifier comprises a vinyl polydimethylsiloxane / polymethylsiloxane sesquisiloxane crosslinked polymer.

4. The freeze-dried foundation containing a biomimetic sebum composition according to claim 1, characterized in that, The colorant includes titanium dioxide and iron oxide, wherein the weight ratio of titanium dioxide to iron oxide is (20-40):(1-5).

5. The freeze-dried foundation containing a biomimetic sebum composition according to claim 1, characterized in that, The excipients include at least one of mannitol and trehalose.

6. The freeze-dried foundation containing a biomimetic sebum composition according to claim 1, characterized in that, The first emulsifier includes at least one of cetyl PEG / PPG-10 / 1 polydimethylsiloxane, PEG-10 polydimethylsiloxane, lauryl PEG-10 tris(trimethoxy)silyl ethyl polydimethylsiloxane, or lauryl PEG-9 polydimethylsiloxane ethyl polydimethylsiloxane.

7. The freeze-dried foundation containing a biomimetic sebum composition according to claim 1, characterized in that, The oily solvent is at least one of cyclopentamethoxysiloxane, polydimethylsiloxane, isononyl isononanoate, isododecane, or isohexadecane.

8. The freeze-dried foundation containing a biomimetic sebum composition according to claim 1, characterized in that, The active ingredient is either ergothioneine or ascorbic acid.

9. The freeze-dried foundation containing a biomimetic sebum composition according to claim 1, characterized in that, The first preservative includes at least one of 1,2-hexanediol, ethylhexylglycerin, or octyl glycol.

10. A method for preparing a freeze-dried foundation containing a biomimetic sebum composition according to claim 2, characterized in that, The preparation method includes the preparation of lyophilized powder phase and the preparation of liquid matrix phase; The preparation of the lyophilized powder phase includes the following steps: (1) Disperse the A-phase raw material evenly in a pulverizer to obtain a mixture of A-phase; (2) Mix the B-phase raw material, C-phase raw material and D-phase raw material evenly to obtain a B-phase mixture, a C-phase mixture and a D-phase mixture; (3) Add the B-phase mixture and the D-phase mixture to the C-phase mixture, homogenize and emulsify to obtain an emulsified slurry; (4) Add the A phase mixture to the emulsion slurry and stir evenly to obtain the slurry to be freeze-dried; (5) The slurry to be freeze-dried is freeze-dried, dried and pulverized to obtain the freeze-dried powder phase; The preparation of the liquid matrix phase includes the following steps: (1) Mix the aqueous raw materials and heat them to 70-90℃ to obtain an aqueous mixture; (2) After homogenizing the oil phase raw material, heat it to 70-90℃ to obtain an oil phase mixture; (3) Add the aqueous phase mixture to the oil phase mixture and homogenize for 1-2 min to obtain the liquid matrix phase; When using, mix the lyophilized powder phase and the liquid matrix phase.

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