Directional separation device for active ingredients in beetroot nitric oxide donor extracting solution

Abstract

The invention discloses a directional separation device for active ingredients in a beetroot nitric oxide donor extracting solution, relates to the technical field of raw material separation devices, and aims to solve the problems of ingredient inactivation, nonuniform dissolution and the like caused by temperature fluctuation in the process of extracting the active ingredients of the beetroot extracting solution. Comprising improvement of a stirring mode, improvement of a temperature / pressure acquisition mode and improvement of a heat exchange process, and specifically comprises the steps that global temperature and pressure data are acquired through a semi-through detection tube, a global temperature and pressure coupling model is established, stirring and heat exchange instructions are generated, and cooperative operation of three-dimensional stirring and efficient and accurate heat exchange is achieved. The method has the key purposes of inhibiting temperature fluctuation or temperature concentration, improving the dissolving efficiency and uniformity of active ingredients and reducing the inactivation rate of the ingredients, is suitable for the directional separation process of the active ingredients such as nitrate in the beetroot nitric oxide donor extracting solution, and can feed back the working state.

Description

Technical Field

[0001] This invention relates to the field of raw material separation device technology, specifically to a device for the targeted separation of active ingredients in beetroot nitric oxide donor extract. Background Technology

[0002] The extraction process for beetroot nitric oxide donor extract is explained below: The main active ingredient is nitrate. Based on its water solubility, a water immersion extraction method is used to efficiently extract it from beetroot. The key processes are water immersion dissolution and purification, with the only commonality being temperature control, as detailed below: The water immersion and dissolution process requires control of temperature (40~59℃) and pH environment, while the purification process is mainly carried out in a low temperature environment. Both processes require avoiding temperature fluctuations or excessively high temperatures that could lead to component inactivation. Specifically, the water immersion and dissolution process is explained as follows: excessively high temperatures will inactivate the components, but excessively low temperatures will affect the water solubility of nitrates. More specifically, if the water temperature fluctuates significantly (e.g., from 35°C to 55°C), although the temperature environment is still within the safe threshold, the excessive temperature rise may pose a safety hazard. This invention proposes a solution to this problem. Summary of the Invention

[0003] The purpose of this invention is to provide a device for the targeted separation of active ingredients in beetroot nitric oxide donor extract. It focuses on the two major steps in the extraction process of active ingredients from beetroot extract, prioritizing temperature fluctuations. The key objective is to reduce the inactivation rate of active ingredients in both steps while maintaining the highest water solubility.

[0004] The objective of this invention can be achieved through the following technical solution: a device for directional separation of active ingredients in beetroot nitric oxide donor extract, comprising a vessel body and a stirring plate, wherein the stirring plate is located at the upper end of the vessel body and is rotatably connected to the vessel body, and the stirring plate is provided with a heat exchange tube and a semi-pass detection tube parallel to the height direction of the vessel body; A low-level stirring assembly is provided between the bottom positions inside the vessel body. A stirring blade and an inflatable bladder are installed on the outer wall of the semi-through detection tube. The semi-through detection tube is arranged in a ring array along the setting direction of the heat exchange tube. The setting height of the inflatable bladder decreases or increases at equal intervals along the clockwise or counterclockwise direction of the stirring plate.

[0005] The configuration is further defined as follows: the heat exchange tube is positioned at the center of the stirring plate, and the vessel body is equipped with a drive motor associated with the stirring plate, a water pump assembly associated with the heat exchange tube, and a detection assembly associated with the semi-pass detection tube.

[0006] The configuration is further defined as follows: the number of semi-pass detection tubes is n, the single rotation angle of the agitator is less than or equal to 360° / n, and the total length of each semi-pass detection tube is equal and they are fixedly connected to the agitator.

[0007] The heat exchange tube is further configured such that it is fixedly connected to the stirring plate, and a vertically distributed water injection pipe is installed at the center point of the heat exchange tube. A spiral blade is provided between the outer wall of the water injection pipe and the inner wall of the heat exchange tube, and a spiral flow channel is formed through the spiral blade.

[0008] The further configuration includes: an open groove connected to the spiral flow channel is provided between the bottom end of the water injection pipe and the bottom end of the inner wall of the heat exchange pipe, and a water outlet is provided above the spiral flow channel on the heat exchange pipe.

[0009] The method is further configured as follows: the temperature and pressure parameters at the corresponding liquid level inside the vessel are obtained through the semi-through detection tube, and a global temperature-pressure coupling model is established using the temperature and pressure parameters. The temperature difference coefficient and pressure difference coefficient are obtained in the global temperature-pressure coupling model, and the stirring command of the associated stirring plate and the heat exchange command of the associated heat exchange tube are generated using the temperature difference coefficient and pressure difference coefficient.

[0010] The present invention has the following beneficial effects: 1. Improved temperature control during the separation of active ingredients: By using n semi-through detection tubes distributed in a ring array, the entire temperature and pressure inside the vessel can be collected. Based on the global temperature and pressure coupling model established by the global data collection, the temperature difference coefficient and pressure difference coefficient can be accurately calculated, and heat exchange commands can be dynamically generated. The heat exchange tubes can enhance the heat exchange efficiency through the spiral flow channel structure, allowing the temperature of the extract to quickly approach the target value (40~59℃ for water immersion and dissolution, and low temperature environment for purification). This effectively controls the temperature fluctuation range and avoids the deactivation of active ingredients such as nitrates due to local high or low temperatures or excessive temperature differences, while ensuring the high water solubility of the active ingredients.

[0011] 2. To supplement the above, the stirring blades on the outer wall of the semi-through detection tube generate a lateral stirring force as the stirring disk rotates, while the inflatable balloons distributed according to an arithmetic progression generate longitudinal turbulence during rotation. Combined with the shear force provided by the low-position stirring component at the bottom of the vessel, a three-dimensional stirring system is constructed. This system not only breaks up the stratification of the extract, ensuring uniform temperature and component distribution, but also accelerates the dissolution of active ingredients, avoiding localized insufficient dissolution. Furthermore, through dynamic adjustment of the stirring intensity, it promotes the diffusion and fusion of the extract in high-concentration and low-concentration areas, improving overall dissolution efficiency and uniformity. The key action is as follows: real-time acquisition of global temperature and pressure data through a semi-through detection tube, followed by analysis by a global temperature and pressure coupling model, which in turn drives the motor (stirring disc) and water pump assembly (heat exchange tube) to generate precise control commands. When the temperature or pressure exceeds the threshold, the system can prioritize correcting the temperature deviation (ensuring the stability of active ingredients) and simultaneously adjust the stirring intensity (improving dissolution uniformity), achieving the dual goals of "temperature stability" and "sufficient dissolution". It can adapt to the dynamic changes in extract density and component concentration during the process without manual intervention, and can also provide feedback on relevant parameters during the separation process. Attached Figure Description

[0012] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0013] Figure 1 This is a schematic diagram of the structure of a device for the targeted separation of active ingredients in beetroot nitric oxide donor extract proposed in this invention; Figure 2 For the present invention Figure 1 Cross-sectional view of the middle vessel body; Figure 3 This is a schematic diagram of the agitator disk in the present invention; Figure 4 This is a cross-sectional view of the heat exchange tube in this invention; Figure 5 For the present invention Figure 4 Diagram showing the bottom middle position.

[0014] In the diagram: 1. Kettle body; 2. Stirring plate; 3. Heat exchange tube; 4. Half-through detection tube; 5. Low-level stirring assembly; 6. Inflatable bladder; 7. Stirring blade; 8. Water injection pipe; 9. Spiral blade; 10. Spiral flow channel. Detailed Implementation

[0015] The technical solution of the present invention will be clearly and completely described below with reference to the embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0016] Example 1: Regarding the two main steps in the extraction process of active ingredients from beet root extract, with temperature fluctuation as a primary consideration, the key objective is to reduce the inactivation rate of active ingredients in both steps while maintaining maximum water solubility. The following technical solution is proposed: Reference Figures 1-5 The active ingredient directional separation device in beetroot nitric oxide donor extract in this embodiment includes a vessel body 1 and a stirring plate 2. The stirring plate 2 is located at the upper end of the vessel body 1 and is rotatably connected to the vessel body 1. The stirring plate 2 is provided with a heat exchange tube 3 and a semi-pass detection tube 4 parallel to the height direction of the vessel body 1. A low-level stirring assembly 5 is installed between the bottom positions inside the vessel body 1. A stirring blade 7 and an inflatable balloon 6 are installed on the outer wall of the semi-through detection tube 4. The semi-through detection tube 4 is arranged in a ring array along the setting direction of the heat exchange tube 3. The setting height of the inflatable balloon 6 decreases or increases at equal intervals along the clockwise or counterclockwise direction of the stirring plate 2. The heat exchange tube 3 is set at the center point of the stirring plate 2. A drive motor associated with the stirring plate 2, a water pump assembly associated with the heat exchange tube 3, and a detection assembly associated with the semi-through detection tube 4 are installed outside the vessel body 1.

[0017] Basic Principle Explanation: The principle of targeted separation of active ingredients in beetroot nitric oxide donor extract is mainly based on the differences in the physical and chemical properties of different active ingredients. Through a series of separation techniques, the target active ingredients are specifically enriched and separated, while impurities are removed. The specific principle can be understood in the following parts, including water immersion dissolution and subsequent purification processes. For example, in the water immersion dissolution process: taking advantage of the difference in solubility of different active ingredients in two immiscible solvents, the extract is mixed with a specific organic solvent. The target nitric oxide donor active ingredient will dissolve more in the organic solvent phase (or aqueous phase), while impurities will dissolve in the other phase. Separation is achieved by liquid-liquid separation. Or in the subsequent purification process, such as concentration and drying, the principle of concentration is to take advantage of the difference in boiling points of different components. The solvent (usually water or ethanol) in the extract is evaporated and removed by vacuum distillation, thus enriching the active ingredients. Based on the above, it can be explained that the overall process involves liquid-solid phase dissolution / slight dissolution / insolution processes, and the key lies in the temperature change. Considering the density change during the liquid-solid phase dissolution process, which leads to liquid pressure fluctuations, this invention uses temperature and liquid pressure as two important indicators to provide feedback on the state during the preparation process. The first is to avoid temperature-induced activity, and the second is to provide feedback on the extraction and purification status.

[0018] Example 2: Based on Example 1, a supplementary scheme is proposed regarding the stirring and heat exchange processes: The number of semi-through detection tubes 4 is n. The single rotation angle of the stirring plate 2 is less than or equal to 360° / n. The total length of each semi-through detection tube 4 is equal and it is fixedly connected to the stirring plate 2. The heat exchange tube 3 is fixedly connected to the stirring plate 2. A vertically distributed water injection pipe 8 is installed at the center point of the heat exchange tube 3. A spiral blade 9 is provided between the outer wall of the water injection pipe 8 and the inner wall of the heat exchange tube 3, and a spiral flow groove 10 is formed through the spiral blade 9. An opening groove connected to the spiral flow groove 10 is provided between the bottom end of the water injection pipe 8 and the bottom end of the inner wall of the heat exchange tube 3. A water outlet is provided above the spiral flow groove 10 corresponding to the position of the heat exchange tube 3.

[0019] Solution Description: First, the stirring process is explained: This embodiment is mainly based on a drive motor, which is mainly used to drive the semi-through detection tube 4 to rotate in a directional and fixed angle. After the drive motor starts, it drives the stirring plate 2 to rotate. Since the single rotation angle is limited to within 360° / n, the n semi-through detection tubes 4 arranged in a ring array can sequentially perform full-coverage detection of the extract in different areas of the vessel 1, avoiding detection blind spots. When the semi-through detection tube 4 rotates with the stirring plate 2, the stirring blade 7 on its outer wall rotates synchronously, forming a lateral stirring force on the extract, breaking the liquid stratification phenomenon, and making the temperature and component distribution of the extract more uniform. The inflatable balloons 6 distributed on the semi-through detection tube 4 in an arithmetic progression form a longitudinal turbulence due to the height difference during rotation. Combined with the lateral stirring of the stirring blade 7, the extract is stirred in three dimensions, which not only improves the dissolution efficiency of the active ingredients, but also avoids the problem of local temperature being too high or too low. Regarding the heat exchange process, it should be noted that: the heat exchange tube 3 and the stirring plate 2 are fixedly connected, and a vertically distributed water injection pipe 8 is installed at the center of the heat exchange tube 3. A spiral blade 9 is installed between the outer wall of the water injection pipe 8 and the inner wall of the heat exchange tube 3, forming a spiral flow channel 10. An opening groove communicating with the spiral flow channel 10 is provided between the bottom end of the water injection pipe 8 and the bottom end of the inner wall of the heat exchange tube 3. An outlet is provided above the spiral flow channel 10 on the heat exchange tube 3. Using a conventional water pump, the pump assembly injects the heat exchange medium (heating or cooling medium) into the water injection pipe 8. The heat exchange medium enters the spiral flow channel 10 through the opening groove at the bottom end of the water injection pipe 8. Since the spiral flow channel 10 is formed by the spiral blade 9 cooperating with the heat exchange tube 3 and the water injection... With the formation of tube 8, the heat exchange medium flows in a spiral upward state, which greatly increases the contact area and contact time with the inner wall of the heat exchange tube 3, thus improving the heat exchange efficiency. When the heat exchange tube 3 rotates synchronously with the stirring plate 2, a coating can be added to the heat exchange tube 3 to increase the frictional resistance relative to the fluid. The outer wall of the tube forms relative motion with the extract, which further enhances the heat exchange effect and ensures that the temperature of the extract in the vessel 1 can quickly approach the target value. The heat-exchanged medium is discharged from the outlet, forming a closed-loop heat exchange system, which ensures the continuity and stability of the heat exchange process. This structural design avoids the problem of uneven local heat exchange in traditional heat exchange methods, effectively controls the temperature fluctuation range, and provides a guarantee for the stable extraction of active ingredients.

[0020] However, in conjunction with the above, the following explanation regarding the inflatable bladder 6 is provided: If the liquid pressure is only related to the liquid density and liquid level, the liquid level of each inflatable bladder 6 is known in the initial state. However, the liquid density fluctuates at different depths due to the degree of dissolution in water immersion, thus causing pressure fluctuations as well. To address this, while the stirring plate 2 remains constant, the pressure and temperature values ​​at corresponding locations are obtained through the inflatable bladder 6. Furthermore, after the stirring plate 2 rotates by an angle (0~360° / n), pressure and temperature values ​​at other locations can be obtained. The main purpose is to provide feedback on the pressure and temperature fluctuations throughout the entire interior of the vessel 1, preventing excessively high local temperatures that could lead to component deactivation or excessively low local dissolution. (Refer to...) Figure 2 The overall solution can also include a low-level stirring component 5 at the bottom of the vessel body 1. Its essence can be referenced to a magnetic stirring structure without a direct connection, which only provides shear force.

[0021] Example 3: Supplementary explanation regarding the global temperature-pressure coupling model in Example 2: The temperature and pressure parameters at the corresponding liquid level inside the vessel 1 are obtained through the semi-through detection tube 4. A global temperature-pressure coupling model is established based on the temperature and pressure parameters. The temperature difference coefficient and pressure difference coefficient are obtained in the global temperature-pressure coupling model. The stirring command of the associated stirring plate 2 and the heat exchange command of the associated heat exchange tube 3 are generated based on the temperature difference coefficient and pressure difference coefficient.

[0022] Solution Description: Supplementary explanation based on Example 2: First, each inflatable bladder 6 can be numbered with 'n' according to its position. In the initial state, the temperature and pressure parameters at each number are recorded in real time. However, after the stirring plate 2 rotates a certain angle, the temperature and pressure parameters at each number are updated and recorded again, specifically as follows: S1: Based on the annular array distribution of the semi-through detection tube 4 in Example 1 and the rotation mode of "single rotation angle ≤ 360° / n" in Example 2, the semi-through detection tube 4 can collect the temperature values ​​T(x,y,z) and pressure parameters P(x,y,z) at different spatial positions and liquid levels in the vessel 1 in real time during the rotation of the stirring plate 2. x,y,z are mainly used to represent the spatial coordinates of the inflatable bladder 6, specifically in a three-dimensional coordinate system, such as z representing the relative height of the inflatable bladder 6, forming a three-dimensional matrix of global data. The temperature data directly reflects the thermal environment state of the extract, and the pressure data indirectly reflects the density distribution of the extract (the density changes due to the different degrees of dissolution of the active ingredients, which in turn cause pressure fluctuations). Together, they constitute the core feedback index of the active ingredient extraction state. This part is the basic technical principle of the present invention. S2: The global temperature and pressure coupling model is based on the principle of thermodynamic equilibrium (indirect heat transfer calculation) and the laws of fluid mechanics (liquid pressure calculation). It couples and correlates the collected temperature and pressure data. First, it defines the temperature difference coefficient ΔT=[T(x,y,z)-T0] / T0 (where T0 is the target temperature, which is determined according to different component ratios, and is a relative constant in this invention), which is used to feed back the deviation between the actual temperature and the target temperature and the spatial distribution difference. Similarly, it defines the pressure difference coefficient ΔP=[P(x,y,z)-P0] / P0 (where P0 is the target pressure, which is oriented by the ideal density of the extract at the target temperature, and is also a relative constant in this invention), which is used to feed back the deviation between the actual pressure and the ideal pressure, and indirectly reflects the dissolution uniformity of the active ingredients. S3: Using the temperature difference coefficient ΔT and pressure difference coefficient ΔP output by the global temperature-pressure coupling model as control signals, and considering the temperature value, the ideal temperature distribution is a relatively uniform state, such as the temperature values ​​of the inflatable bladder 6 being relatively consistent at all locations. Therefore, a temperature threshold is set, and similarly, a pressure threshold related to the pressure data is set, forming the following dynamic adjustment method: S3-1: When the absolute value of ΔT is greater than the temperature threshold (i.e., the temperature fluctuation exceeds the allowable range): If ΔT is positive (temperature is too high), a cooling command is generated for heat exchange tube 3, the water pump assembly increases the flow rate of the cooling medium, and at the same time, based on the spatial distribution data of ΔT, the rotation speed of the stirring plate 2 is adjusted (the greater the temperature difference, the higher the rotation speed), and the three-dimensional stirring method in Example 2 is used to accelerate heat diffusion and avoid local temperature concentration leading to component deactivation; If ΔT is negative (temperature is too low), a heating command is generated, the water pump assembly increases the flow rate of the heating medium, and at the same time, the rotation speed of the stirring plate 2 is appropriately reduced to avoid excessive heat loss; S3-2: When the absolute value of ΔP is greater than the pressure threshold (i.e., the pressure fluctuation exceeds the allowable range, indirectly reflecting uneven dissolution of components): regardless of whether ΔT is within the pressure threshold, a stirring intensity adjustment command is generated. If ΔP is positive (high local pressure, high density, and sufficient dissolution of components), the stirring disk 2 is controlled to accelerate in the direction corresponding to that region. Through the turbulence effect of the stirring plate 7 and the inflatable balloon 6, the extract from the high-concentration region is diffused to the low-concentration region. If ΔP is negative (low local pressure, low density, and insufficient dissolution of components), the stirring disk 2 is controlled to increase the stirring frequency in that region, while coordinating with the temperature fine-tuning of the heat exchange tube 3 to improve the dissolution efficiency of the active ingredients in that region. S3-3: When both ΔT and ΔP exceed their respective set thresholds, the heat exchange system is preferentially adjusted to quickly correct the temperature deviation (ensuring no loss of active ingredients). Simultaneously, the stirring system is adjusted to improve component uniformity. Through the synergistic effect of these two systems, the dual goals of "temperature stability" and "sufficient dissolution" are achieved. For example, if a region experiences both positive ΔT and negative ΔP, the system first activates the cooling program of heat exchange tube 3 to bring the temperature back to the target range. Then, the stirring intensity in that region is increased to promote the dissolution of active ingredients, preventing component deactivation due to excessive temperature while resolving the problem of uneven dissolution.

[0023] In addition to the above, it is necessary to add the following: Under the premise that the temperature data throughout the entire interior of vessel 1 is relatively constant, and the pressure data is used as the only parameter, referring to the pressure calculation formula, such as p1=ρi*g*h1, ..., pn=ρi*g*hn, where h1~hn only represent the height of the inflatable bladders 6, then without considering the method of determining the pressure difference formula, ensuring that p1, p2...pn always maintain a relatively constant value, can indicate that the raw materials inside vessel 1 have reached the optimal degree of dissolution. For example, if the distance L between each inflatable bladder 6 is , and the height h between the uppermost inflatable bladder 6 and the liquid surface is , then p1=ρi*g*h, p2=ρi*g*(h+L), and the pressure ratio in two adjacent inflatable bladders 6 is always maintained at h / (h+L), (h+L) / (h+2L), etc.

[0024] The preferred embodiments of the present invention disclosed above are merely illustrative of the invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the invention to specific implementations. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of the invention, thereby enabling those skilled in the art to better understand and utilize the invention. The invention is limited only by the claims and their full scope and equivalents.

Claims

1. A device for the directional separation of active ingredients in a beetroot nitric oxide donor extract, comprising a vessel body (1) and a stirring plate (2), characterized in that, The stirring plate (2) is located at the upper end of the vessel body (1) and is rotatably connected to the vessel body (1). The stirring plate (2) is provided with a heat exchange tube (3) and a semi-pass detection tube (4) parallel to the height direction of the vessel body (1). A low-level stirring assembly (5) is provided between the bottom positions inside the vessel body (1). A stirring plate (7) and an inflatable balloon (6) are installed on the outer wall of the semi-through detection tube (4). The semi-through detection tube (4) is arranged in a ring array along the setting direction of the heat exchange tube (3). The setting height of the inflatable balloon (6) decreases or increases at equal intervals along the clockwise or counterclockwise direction of the stirring plate (2).

2. The device for targeted separation of active ingredients in beetroot nitric oxide donor extract according to claim 1, characterized in that, The heat exchange tube (3) is located at the center of the stirring plate (2). The vessel body (1) is equipped with a drive motor associated with the stirring plate (2), a water pump assembly associated with the heat exchange tube (3), and a detection assembly associated with the semi-identical detection tube (4).

3. The device for targeted separation of active ingredients in beetroot nitric oxide donor extract according to claim 2, characterized in that, The number of semi-through detection tubes (4) is n, the single rotation angle of the agitator (2) is less than or equal to 360° / n, and the total length of each semi-through detection tube (4) is equal and it is fixedly connected to the agitator (2).

4. The device for targeted separation of active ingredients in beetroot nitric oxide donor extract according to claim 3, characterized in that, The heat exchange tube (3) is fixedly connected to the stirring plate (2), and a water injection pipe (8) is installed at the center of the heat exchange tube (3) in a vertically distributed manner. A spiral blade (9) is provided between the outer wall of the water injection pipe (8) and the inner wall of the heat exchange tube (3), and a spiral flow channel (10) is formed through the spiral blade (9).

5. The device for targeted separation of active ingredients in beetroot nitric oxide donor extract according to claim 4, characterized in that, An opening groove connected to the spiral flow channel (10) is provided between the bottom end of the water injection pipe (8) and the bottom end of the inner wall of the heat exchange pipe (3), and an outlet is provided on the heat exchange pipe (3) above the spiral flow channel (10).

6. The device for targeted separation of active ingredients in beetroot nitric oxide donor extract according to claim 5, characterized in that, The temperature and pressure parameters in the corresponding liquid level inside the vessel (1) are obtained through the semi-through detection tube (4), and a global temperature and pressure coupling model is established with the temperature and pressure parameters. The temperature difference coefficient and pressure difference coefficient are obtained in the global temperature and pressure coupling model, and the stirring command of the associated stirring plate (2) and the heat exchange command of the associated heat exchange tube (3) are generated with the temperature difference coefficient and pressure difference coefficient.

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