Preparation method of carrier-free 65Zn tracer agent
By combining hydrochloric acid-hydrogen peroxide dissolution with TK201 extraction resin column, the problem of low separation efficiency of carrier-free 65Zn tracer was solved, achieving efficient and selective 65Zn separation with high recovery rate and low copper contamination factor.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-04
- Publication Date
- 2026-03-17
AI Technical Summary
Existing technologies have low separation efficiency and poor performance in preparing carrier-free 65Zn tracers, especially when using ion exchange and evaporation methods, the efficiency is significantly low.
The copper target was dissolved using a hydrochloric acid-hydrogen peroxide mixed solution and then separated using a TK201 extraction resin column, including rinsing and desorption steps. The TK201 extraction resin column was used to efficiently separate 65Zn from the copper target, and the target was further treated with hydrochloric acid solutions of different concentrations and deionized water.
It achieves highly selective and efficient 65Zn separation with a recovery rate of over 99% and a copper decontamination factor of over 105, significantly improving the separation effect.
Abstract
Description
Technical Field
[0001] This invention belongs to the field of radiochemical separation tracer preparation technology, specifically relating to a carrier-free tracer. 65 Zn tracer preparation method. Background Technology
[0002] 65 Zn is a commonly used tracer for studying biological metabolism and the Zn cycle in ecosystems. It has a half-life of 244 days and is typically produced by bombarding a Cu target with protons, deuterium nuclei, or alpha atoms. To prepare... 65 Zn products also need to be separated from Cu and other irradiation byproducts.
[0003] Currently, the main separation and purification methods include ion exchange, extraction, and evaporation. 65 Zn.
[0004] Susanta Lahiri et al. (Simultaneous production of carrier-free 65 Zn and 66,67, 68 Ga in α-particle activated copper target and their separation with TOA, Applied Radiation and Isotopes, 1997, 48(1): 15-18) A carrier-free solution was prepared by solution extraction and separation of a copper target irradiated with α-particles using TOA. 65 Zn products, but only 65 Zn was extracted into TOA without reverse extraction with water, which is detrimental. 65 Measurement and use of Zn. G. Lucconi et al. (Effective production of Zn) 65 Zn with a PETcylotron, Applied Radiation and Isotopes, 2012, 70: 1590-1594) was obtained by proton irradiation of a copper target using a medical PET cyclotron, followed by separation using AG 1×8 anion exchange resin. 65 Zn products. WC Parker et al. (Rapid carrier-free separation technique, 1961, 14: 71-75) used the property of Zn's easy sublimation to separate copper targets and Zn by evaporation. 65 Zn products, but the separation efficiency is obviously very low. Summary of the Invention
[0005] To overcome the challenges of preparing carrier-free materials 65 When separating Zn products from copper targets, the process suffers from low efficiency and poor performance. This invention proposes a carrier-free method. 65 Zn tracer preparation method.
[0006] The technical solution adopted by this invention to solve its technical problem is: A carrier-free 65 The method for preparing Zn tracers includes the following steps: Step 1, Cu target dissolution A Cu target irradiated by nuclear radiation was dissolved in a mixed solution of hydrochloric acid and hydrogen peroxide to obtain a Cu target solution.
[0007] Step 2: Evaporation of Cu target solution and dissolution with hydrochloric acid. Evaporation of the Cu target solution; The residue after evaporation was dissolved in hydrochloric acid to obtain a Cu target hydrochloric acid solution.
[0008] Step 3: The Cu-target hydrochloric acid solution is passed through a TK201 extraction resin column. The Cu target hydrochloric acid solution was passed through a TK201 extraction resin column, and the effluent was waste liquid.
[0009] Step 4, Rinse The TK201 extraction resin column through which the Cu target hydrochloric acid solution passed was rinsed with hydrochloric acid solution.
[0010] Step 5, desorption The TK201 extraction resin column was desorbed and washed using hydrochloric acid solution (pH 1.5–3.0) or deionized water, and the effluent was carrier-free. 65 Zn tracer solution.
[0011] In the above preparation method, in step 1, the hydrochloric acid-hydrogen peroxide mixed solution is a mixed solution of concentrated hydrochloric acid and 30% hydrogen peroxide, and the volume ratio of concentrated hydrochloric acid to 30% hydrogen peroxide is 1:0.5~10.
[0012] In the above preparation method, in step 1, the nuclear-irradiated Cu target is a Cu target irradiated by α particles, protons, or deuterium nuclei.
[0013] In the above preparation method, in step 2, the concentration of hydrochloric acid used to dissolve the evaporation residue is 0.1 mol / L to 1.0 mol / L.
[0014] In the above preparation method, in step 3, the diameter of the TK201 extraction resin column is 5mm~10mm, and the bed height is 30mm~60mm.
[0015] In the preparation method described above, in step 4, the concentration of the hydrochloric acid solution used for rinsing is 0.1 mol / L to 1.0 mol / L.
[0016] The beneficial effects of this invention are: A carrier-free 65 The method for preparing Zn tracers using a TK201 extraction resin column exhibits high selectivity and high efficiency.
[0017] A carrier-free 65 A method for preparing Zn tracers, utilizing TK201 extraction resin to... 65 Zn was isolated from a large copper irradiated target, and... 65 Zn recovery rate exceeds 99%, while copper decontamination factor exceeds 10. 5 . Detailed Implementation
[0018] The present invention will be further described in detail below with reference to specific embodiments.
[0019] A carrier-free 65 The method for preparing Zn tracers includes the following steps: Step 1: Dissolve the Cu target irradiated with α particles, protons, or deuterium nuclei using a hydrochloric acid-hydrogen peroxide mixed solution; The hydrochloric acid-hydrogen peroxide mixed solution is prepared by mixing commercially available concentrated hydrochloric acid and commercially available 30% hydrogen peroxide in a volume ratio of 1:0.5~10.
[0020] Step 2: After evaporating the solution from Step 1 to dryness, dissolve it in hydrochloric acid of a certain concentration. The concentration of the hydrochloric acid solution for dissolving the Cu target is 0.1~1 mol / L.
[0021] Step 3: Load the solution from Step 2 onto a TK201 resin column; The TK201 extraction resin column has a diameter of 5~10 mm and a bed height of 3~6 cm.
[0022] Step 4: Rinse the TK201 extraction resin column after sample loading in Step 3 with hydrochloric acid solution; The concentration of the hydrochloric acid solution used for rinsing is 0.1~1 mol / L, and the volume is 10~80 mL.
[0023] Step 5: Desorb the TK201 resin column treated in Step 4 using hydrochloric acid solution. 65 Zn.
[0024] The desorption 65 The desorption solution for Zn is a hydrochloric acid solution with a pH of 1.5-6 and a volume of 8-35 mL.
[0025] Example 1 1 g of copper target irradiated with 10 MeV α ions was dissolved in a mixed solution containing 30 mL concentrated hydrochloric acid and 10 mL 30% hydrogen peroxide solution, evaporated to dryness, dissolved in 10 mL 1 mol / L hydrochloric acid, extracted with a TK201 column, washed with 50 mL of 1 mol / L hydrochloric acid solution, and finally desorbed with 30 mL of pH 3 hydrochloric acid solution to obtain a carrier-free target. 65 Zn tracer solution, in which 65 The Zn recovery rate was 99.2%, and the Cu decontamination factor was 1.5 × 10⁻⁶. 5 .
[0026] Example 2 0.5 g of proton-irradiated copper target was dissolved in a mixed solution containing 20 mL of concentrated hydrochloric acid and 20 mL of 30% hydrogen peroxide solution, evaporated to dryness, dissolved in 5 mL of 0.3 mol / L hydrochloric acid, extracted using a TK201 column, washed with 80 mL of 0.3 mol / L hydrochloric acid solution, and finally desorbed with 50 mL of pH 2 hydrochloric acid solution to obtain a carrier-free target. 65 Zn tracer solution, in which 65 The Zn recovery rate was 99.5%, and the Cu decontamination factor was 3 × 10⁻⁶. 5 .
[0027] Example 3 Two g of Cu target irradiated with tritium nuclei were dissolved in a mixed solution containing 40 mL of concentrated hydrochloric acid and 10 mL of 30% hydrogen peroxide solution. The solution was evaporated to near dryness, dissolved in 6 mL of 0.5 mol / L hydrochloric acid, and extracted using a TK201 column. The solution was then washed with 40 mL of 1 mol / L hydrochloric acid, and finally desorbed with 40 mL of deionized water to obtain a carrier-free target. 65 Zn tracer solution, in which 65 The Zn recovery rate was 99.0%, and the Cu decontamination factor was 1.2 × 10⁻⁶. 5 .
Claims
1. A carrier-free 65 A method for the preparation of a Zn tracer, characterized in that, The method comprises the following steps: Step 1, Cu target dissolution: A nuclear irradiated Cu target is dissolved by using a hydrochloric acid-hydrogen peroxide mixed solution to obtain a Cu target dissolution solution; Step 2, Cu target dissolution solution evaporation and hydrochloric acid dissolution: The Cu target dissolution solution is evaporated; The evaporation residue is dissolved by using hydrochloric acid to obtain a Cu target hydrochloric acid solution; Step 3, Cu target hydrochloric acid solution through a TK201 elution resin column: The Cu target hydrochloric acid solution is passed through a TK201 elution resin column; Step 4, elution: The TK201 elution resin column through which the Cu target hydrochloric acid solution is passed is eluted by using a hydrochloric acid solution; Step 5, desorption: The TK201 elution resin column after elution is desorbed by using hydrochloric acid solution with pH 1.5~3.0 or deionized water, and the effluent is carrier-free 65 Zn tracer solution.
2. The vector-free composition of claim 1 65 A method for preparing a Zn tracer, characterized by, In the step 1, the hydrochloric acid-hydrogen peroxide mixed solution is a concentrated hydrochloric acid-30% hydrogen peroxide mixed solution, and the volume ratio of the concentrated hydrochloric acid to the 30% hydrogen peroxide is 1:0.5-10.
3. The carrier- free of claim 1 65 A method for preparing a Zn tracer, characterized by, In the step 1, the nuclear irradiated Cu target is a Cu target irradiated by alpha particles, protons or deuterium nuclei.
4. The carrier- free of claim 1 65 A method for preparing a Zn tracer, characterized by, In the step 2, the concentration of the hydrochloric acid used for dissolving the evaporation residue is 0.1-1.0 mol / L.
5. The carrier- free of claim 1 65 A method for preparing a Zn tracer, characterized by, In the step 3, the diameter of the TK201 elution resin column is 5-10 mm, and the bed height is 30-60 mm.
6. The carrier- free of claim 1 65 A method for preparing a Zn tracer, characterized by, In the step 4, the concentration of the hydrochloric acid solution used for elution is 0.1-1.0 mol / L.