Negative-pressure isolated storage and split charging device and control method thereof
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-16
- Publication Date
- 2026-03-27
Smart Images
Figure CN121734735A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of production purification equipment, and more particularly to a negative pressure isolation storage and dispensing system. Background Technology
[0002] In the production or operation of biological and chemical materials, it is necessary to prevent the contamination of raw materials and avoid the cleanliness of the operation area. Since contaminated raw materials and operation areas can affect the final experimental results and production quality, a special isolation device is needed that can quickly react and eliminate the source of contamination caused by the operation.
[0003] In the field of biochemistry, heat treatment processes are often unavoidable. These processes involve the introduction of heating media, typically water or oil. While these media generally have good thermal stability, at high temperatures, they can condense into fine particles that escape into the operating space, causing irreversible contamination of the biochemical raw materials. Furthermore, heat treatment processes can also cause certain raw materials to escape into confined spaces, leading to adverse effects and making the overall environment of these closed cavities unmonitorable and unpredictable. Additionally, the small particle size makes them easily inhaled by operators during operation, significantly impacting their safety. Therefore, direct contact between operators and drugs must be avoided during operation, and the release of particulate materials into the environment must be prevented.
[0004] Traditional isolation systems typically rely on negative pressure created by airflow for ventilation. This method is slow and cannot quickly handle airborne contaminants (such as fine particles), making it generally suitable for scenarios without volatile substances or pollution sources. However, for work scenarios involving heat treatment processes or operations with volatile raw materials, traditional equipment cannot guarantee a clean environment. Especially during prolonged heating operations, the temperature within the isolation space can rise, further exacerbating the storage of pharmaceuticals. Therefore, traditional isolation equipment reduces operational safety and poses a risk of contaminating pharmaceuticals within the isolation space.
[0005] Based on the problems and operational risks of existing isolation devices, especially for platforms that require heating operations in the isolation space, this invention aims to provide a compact and safe isolation system, as well as a method for operating the isolation system. Summary of the Invention
[0006] To address the problems in the prior art, the present invention provides a negative pressure isolation storage and dispensing system. This negative pressure isolation storage and dispensing system can be applied to long-term heating treatment operations or operations involving volatile raw materials, effectively reducing operational risks while ensuring the safety of the stored raw materials and the cleanliness of the operating space within the isolation system.
[0007] When heating is performed in this negative pressure isolation storage and dispensing system, the system can actively detect changes in temperature, humidity, and particle size. It can also adjust the system's operating status based on these changes, thereby controlling the environment within the negative pressure isolation storage and dispensing system to stabilize the environment, quickly remove contaminants, and regulate temperature and humidity. This protects the stored medicines from contamination and reduces the operator's operational risks.
[0008] Specifically, one aspect of this invention is to provide a negative pressure isolation storage and dispensing device, which includes a reaction unit, a storage unit, a material mixing unit, a gas path unit, and a liquid path unit. The gas path unit adjusts the environment within the negative pressure isolation storage device based on changes in temperature, humidity, and particle size around the reaction unit, ensuring the cleanliness of the device and improving the safety of the system. Furthermore, the storage unit and mixing unit are independently configured to maintain cleanliness within the device and prevent contamination caused by changes in the microenvironment within the device due to the reaction unit.
[0009] Furthermore, the present invention also provides a control method for a negative pressure isolation storage and dispensing device. This control method includes actively controlling the gas path unit based on changes in factors such as temperature, humidity, and particle size within the negative pressure isolation storage and dispensing device, especially changes in the particle size change rate. By adjusting the working combination of the gas path unit, the microenvironment within the negative pressure isolation storage and dispensing device is stabilized, thereby improving the operational safety of the negative pressure isolation storage and dispensing device and preventing contamination of operators or the environment by substances within the negative pressure isolation storage and dispensing device. This makes the negative pressure isolation storage and dispensing device more suitable for operating procedures involving heating reactions or working environments containing volatile raw materials.
[0010] Furthermore, the present invention provides a negative pressure isolation storage and dispensing device, which includes a reaction unit, a storage unit, a material mixing unit, a gas path unit, a liquid path unit, and a detection and control unit; The negative pressure isolation storage and dispensing device can be applied to the operating environment of heat treatment processes or reactions or working environments where volatile raw materials are present, especially long-term heat treatment processes or reactions. The aforementioned negative pressure isolation storage and dispensing device can comprehensively regulate the gas path unit within the device based on changes in the internal environment caused by thermal reactions, thereby stabilizing the internal environment and making long-term heat treatment processes safer. It also ensures the safety of raw materials stored within the device and isolates the materials from the environment, reducing environmental pollution.
[0011] Specifically, the negative pressure isolation storage and dispensing device includes a device support frame, which is assembled in a sealed manner using a transparent material to form a closed cavity; the closed cavity contains a platform for operation. The transparent material includes inorganic glass or organic glass; Furthermore, the reaction unit, storage unit, material mixing unit, gas path unit, and liquid path unit of the negative pressure isolation storage and dispensing device are all mounted on the device support. The reaction unit is set in the cavity formed by the support and the transparent material, and the reaction unit includes a reaction support and an explosion-proof socket interface. The aforementioned reaction support is used to mount reaction devices, such as rotary evaporators, heating plates, and encapsulation plates. The reaction unit includes reaction equipment capable of providing long-term thermal reactions; Explosion-proof sockets can provide power to reaction equipment; Furthermore, the storage unit is mounted on the negative pressure isolation storage and dispensing device; The storage unit is a drying box, used to store materials or balance the humidity of materials; The storage unit and the reaction unit are arranged side by side; Furthermore, the negative pressure isolation storage and dispensing device also includes a material mixing unit, wherein the storage unit and the reaction unit are separated from the material mixing unit, and further, the separation is achieved by a movable partition, specifically a manually operated door.
[0012] Specifically, the material mixing unit is located on the other side of the storage unit; by manually lifting the door, the material mixing unit can be isolated from the storage unit and the reaction unit into an independent space.
[0013] The material mixing unit includes a mixer, which is mounted on the support of the negative pressure isolation storage and dispensing device; The mixer is connected to an external power source, and the mixer can be a stirring head or other mixing device; Furthermore, the negative pressure isolation storage and dispensing device also includes a gas circuit unit; The air passage unit is located at the upper end of the cavity formed by the support and the transparent material, and is used to control the microenvironment within the cavity; Furthermore, the gas path unit includes an exhaust filter assembly and a vacuum filter assembly; The exhaust filter assembly includes an exhaust filter and an exhaust fan, and the exhaust filter and the exhaust fan are connected. The vacuum filter assembly includes a vacuum valve and a vacuum filter, wherein the vacuum valve is connected to the vacuum filter, and the vacuum valve is also connected to a vacuum generating unit, which includes a vacuum environment created by a vacuum pump. Furthermore, the air circuit unit also includes a fresh air assembly, which includes a fresh air valve and an air intake filter, and the fresh air valve and the air intake filter are connected. The aforementioned fresh air assembly is used to filter and deliver air from outside the negative pressure isolation storage and dispensing device into the sealed cavity of the negative pressure isolation storage and dispensing device.
[0014] Preferably, the air passage unit includes at least two sets of exhaust filter assemblies; Wherein, at least one of the exhaust filter groups is installed at the upper end of the reaction unit; Furthermore, the negative pressure isolation storage and dispensing device also includes a water circuit unit; The water system unit includes a cleaning water system component installed at the upper end of the cavity formed by the bracket and the transparent material; and a waste liquid water system component installed on one side of the user operation platform. The cleaning water system assembly includes a water pipe and at least one nozzle connected to the water pipe; The water pipe is connected to the cleaning water interface and the compressed air interface, and a gas-liquid mixing chamber is provided between the water pipe and the nozzle. The gas and liquid introduced through the cleaning water interface and compressed air interface are mixed in the mixing chamber, and the nozzle can spray high-pressure water to facilitate the cleaning of the negative pressure isolation storage and dispensing device.
[0015] Furthermore, the waste liquid water circuit assembly on one side of the operating platform is a waste liquid tank with an incline, through which waste liquid can enter the waste liquid tank via the drain valve 54.
[0016] Furthermore, the negative pressure isolation storage and dispensing device also includes a detection and control unit; The detection and control unit can monitor the temperature, humidity, and particle size information of the sealed environment of the negative pressure isolation storage and dispensing device, and can also detect the working status of the gas circuit unit and the liquid circuit unit. The detection and control unit can also control the operation of the gas circuit unit and the drying unit.
[0017] On the other hand, the present invention also provides a control method for a negative pressure isolation storage and dispensing device, wherein the negative pressure isolation storage and dispensing device includes a detection and control unit and an air circuit unit, wherein the air circuit unit includes an exhaust filter assembly, a vacuum filter assembly, and a fresh air assembly.
[0018] The detection and control unit is electrically connected to the air circuit unit. The detection and control unit detects the temperature, humidity, and particle size data inside the cavity of the negative pressure isolation storage and dispensing device. When the temperature exceeds a preset first temperature threshold, the detection and control unit controls the exhaust filter assembly of the air circuit unit and increases the exhaust fan power of the exhaust filter assembly. At the same time, it opens the fresh air valve of the fresh air assembly, allowing fresh air to enter the cavity of the negative pressure isolation storage and dispensing device. When the temperature rises from the first temperature threshold to a second temperature threshold, the detection and control unit controls the vacuum valve of the vacuum filter assembly of the air circuit unit to open, quickly reducing the temperature inside the cavity of the negative pressure isolation storage and dispensing device, thus enabling the temperature inside the negative pressure isolation storage and dispensing device to decrease rapidly.
[0019] Furthermore, when the temperature inside the cavity of the negative pressure isolation storage and dispensing device drops to between the second temperature threshold and the first temperature threshold, the detection and control unit controls the vacuum valve of the vacuum filter assembly of the gas path unit to close, thereby adjusting the negative pressure state inside the cavity of the negative pressure isolation storage and dispensing device.
[0020] Furthermore, the first temperature threshold and the second temperature threshold can be set according to the operation and reaction requirements of the negative pressure isolation storage and dispensing device.
[0021] In another embodiment, the detection and control unit can detect humidity changes in the cavity of the negative pressure isolation storage and dispensing device. When the humidity exceeds a first humidity threshold, the detection and control unit controls the exhaust filter assembly of the air circuit unit and increases the exhaust fan power of the exhaust filter assembly. Simultaneously, it opens the fresh air valve of the fresh air assembly, allowing fresh air to enter the cavity of the negative pressure isolation storage and dispensing device to regulate the humidity. When the humidity rises from the first humidity threshold to a second humidity threshold, the detection and control unit controls the vacuum valve of the vacuum filter assembly of the air circuit unit to open, rapidly reducing the humidity in the cavity of the negative pressure isolation storage and dispensing device, thereby rapidly lowering the temperature inside the negative pressure isolation storage and dispensing device.
[0022] When the humidity inside the cavity of the negative pressure isolation storage and dispensing device drops to between the second humidity threshold and the first humidity threshold, the detection and control unit controls the vacuum valve of the vacuum filter assembly of the gas path unit to close, thereby adjusting the negative pressure state inside the cavity of the negative pressure isolation storage and dispensing device.
[0023] When the humidity inside the cavity of the negative pressure isolation storage and dispensing device drops below the first humidity threshold, the detection control unit controls the exhaust filter assembly of the air circuit unit and reduces the exhaust fan power of the exhaust filter assembly. In another embodiment, the detection and control unit can detect changes in particle size within the cavity of the negative pressure isolation storage and dispensing device. When the humidity exceeds a first particle size threshold, the detection and control unit controls the exhaust filter assembly of the air circuit unit and increases the exhaust fan power of the exhaust filter assembly, while simultaneously closing the fresh air valve of the fresh air assembly to prevent fresh air from entering the device and quickly reduce particles within the cavity of the negative pressure isolation storage and dispensing device. When the humidity rises from the first particle size threshold to a second particle size threshold, the detection and control unit controls the vacuum valve of the vacuum filter assembly of the air circuit unit to open, quickly reducing particulate matter in the environment within the cavity of the negative pressure isolation storage and dispensing device. When the particle size in the cavity of the negative pressure isolation storage and dispensing device decreases to between the second particle size threshold and the first particle size threshold, the detection and control unit controls the vacuum valve of the vacuum filter assembly of the gas path unit to close, thereby adjusting the negative pressure state in the cavity of the negative pressure isolation storage and dispensing device.
[0024] When the humidity inside the cavity of the negative pressure isolation storage and dispensing device drops below the first particle size threshold, the detection and control unit controls the fresh air valve of the fresh air component of the air circuit unit to open and reduces the exhaust fan power of the exhaust filter component to ensure the stability of the negative pressure inside the cavity of the negative pressure isolation storage and dispensing device. In another embodiment, the detection and control unit can detect changes in particle size in the cavity of the negative pressure isolation storage and dispensing device. When the particle size increases beyond the particle size change rate threshold, the detection and control unit controls the exhaust filter assembly of the air circuit unit and increases the exhaust fan power of the exhaust filter assembly. At the same time, the fresh air valve of the fresh air assembly is closed, and the detection and control unit controls the vacuum valve of the vacuum filter assembly of the air circuit unit to open, thereby quickly reducing particulate matter in the environment of the cavity of the negative pressure isolation storage and dispensing device. When the rate of increase in particle size change within the cavity of the negative pressure isolation storage and dispensing device is less than the rate of change threshold, the control system controls the gas path unit based on the first temperature threshold, the second temperature threshold, the first humidity threshold, the second humidity threshold, the first particle size threshold, and the second particle size threshold.
[0025] Compared to existing negative pressure isolation storage and dispensing devices, the present invention includes a gas path unit comprising an exhaust filter assembly, a vacuum filter assembly, and a fresh air assembly. Through the operation of these three components, the temperature, negative pressure, humidity, and particle size of the environment within the cavity of the negative pressure isolation storage and dispensing device are controlled. This negative pressure isolation storage and dispensing device is more suitable for long-term heated reaction operations, and under these harsh conditions, it can effectively ensure the cleanliness of the raw materials stored within the device.
[0026] Furthermore, this invention also provides a control method for a negative pressure isolation storage and dispensing device. In this method, a detection and control unit continuously monitors the microenvironmental indicators within the negative pressure isolation storage and dispensing device. Changes in these indicators are used to control the operation of the gas path unit within the device, thereby achieving stable microenvironment control. In particular, this invention detects particle size within the device and controls the operation of each component of the gas path unit based on particle size and the rate of change in particle size. This rapidly reduces contaminants in the microenvironment within the device, preventing particulate matter dispersed within the device from contaminating other raw materials. Attached Figure Description
[0027] Figure 1 : Front view of the device; Figure 2 Side view of the device; Figure 3 Top view of the device; Figure 4 : Control method flowchart.
[0028] Among them, 11. Rotary evaporator; 12. Socket; 21. Mixer; 22. External power source; 31. Drying oven; 4. Gas circuit unit; 41. Exhaust filter; 42. Exhaust fan; 43. Vacuum valve; 44. Vacuum filter; 45. Exhaust valve; 46. Fresh air valve; 47. Inlet filter; 48. Nitrogen interface; 49. Air inlet; 51. Cleaning water interface; 52. Compressed air interface; 53. Sewage outlet; 54. Drain valve; 61. RTP interface; 62. Instrument panel; 63. Control panel; 71. Sealing machine; 72. Electronic scale; 81. Integrated glove leak detector; 91. Base; 101. Glove hole; 111. Electrical cabinet; 121. Lighting; 131. Manual lifting door. Detailed Implementation
[0029] The following specific embodiments illustrate the implementation of the present invention. Those skilled in the art can understand the advantages and effects of the present invention from the content disclosed in this specification.
[0030] See Figure 1 The image shows a front view of a negative pressure isolation storage and dispensing device provided by the present invention. The negative pressure isolation storage and dispensing device is mounted on a base 91 and includes a reaction unit, a storage unit, a material mixing unit, a gas path unit, a liquid path unit 5, and a detection and control unit. Specifically, the negative pressure isolation storage and dispensing device is assembled from a device support and a transparent base material, and the device support and the transparent base material form a sealed cavity. The transparent base material is also provided with an operating glove hole 101, through which the operator can enter the operating table inside the negative pressure isolation storage and dispensing device to perform experimental operations. Furthermore, the glove hole 101 is located on an openable transparent base material, which is connected to other transparent base materials through hinges and locks, and can be sealed as needed.
[0031] The reaction unit is located on one side of the negative pressure isolation storage and dispensing device, preferably on one side of the device's operating platform. Figure 1 The demonstrated reaction unit corresponds to the area of the rotary evaporator 11. An explosion-proof socket 12 and other connectors that can provide power to the reaction unit are located near the reaction unit. It should be noted that the reaction unit can also be an open flame reaction unit, such as one equipped with an alcohol lamp.
[0032] Furthermore, a storage unit is provided on one side of the reaction unit. The storage unit is a drying oven 31, which has an independent heat source and is heated by electric heating.
[0033] The drying oven 31 is mounted on the support of the negative pressure isolation storage and dispensing device, and the opening of the drying oven 31 is located inside the cavity of the negative pressure isolation storage and dispensing device, which facilitates the operator to quickly remove and store reagents. See appendix Figure 1 and Figure 3 On the other side of the drying unit, a mixing unit is also provided. The mixing unit is separated from the drying unit by a manual lifting door 131, thus isolating the mixing unit from the drying unit and the reaction unit, ensuring that no tiny particles enter the storage and reaction space during the mixing process; see also Figure 2 The mixing unit includes a power output section and a mixer 21. The power output section is an external power source 22. The mixer 21 is installed on the bracket of the negative pressure isolation storage and dispensing device. The external power source 22 is located on the outside of the bracket of the negative pressure isolation storage and dispensing device. This design can effectively increase the space on the operating platform of the negative pressure isolation storage and dispensing device.
[0034] See Figure 1The negative pressure isolation storage and dispensing device also includes an air path unit. The air path unit is located at the upper end of the cavity formed by the device support and the transparent substrate, and is used to control the microenvironment within the cavity. In this embodiment, the air path unit includes an exhaust filter assembly, a vacuum filter assembly, and a fresh air assembly. It should be noted that the air path unit is located at the upper end of the cavity formed by the device support and the transparent substrate, and this part is independent of the operating table of the negative pressure isolation storage and dispensing device. That is, the upper end of the cavity formed by the device support and the transparent substrate is connected to the operating table space through the exhaust filter assembly, the vacuum filter assembly, and the fresh air assembly.
[0035] The key to the negative pressure isolation storage and dispensing device provided in this embodiment lies in controlling the microenvironment within the device cavity to prevent changes in the microenvironment from contaminating other raw materials. During a prolonged heating reaction, heat accumulates in the microenvironment, causing significant changes, most notably an increase in temperature. Simultaneously, the heating reaction increases humidity and particle size within the cavity. Particulate matter, in particular, is a major concern, as reactants or other contaminants can escape into the cavity of the negative pressure isolation storage and dispensing device. This escape of particulate matter can easily contaminate other materials.
[0036] like Figure 1 As shown, in this embodiment, the exhaust filter assembly includes an exhaust filter 41 and an exhaust fan 42, and the exhaust filter 41 and the exhaust fan 42 are connected. Further, the exhaust filter 41 is a two-stage exhaust filter, and the exhaust fan 42 is an explosion-proof exhaust fan. Even further, in the connection between the exhaust filter 41 and the exhaust fan 42, the exhaust filter 41 can be one or two sets of exhaust filters connected to the exhaust fan 42.
[0037] During use, the exhaust fan is always on to ensure that the cavity inside the negative pressure isolation storage and dispensing device is under negative pressure; while the fresh air component is always on to provide filtered gas to the closed cavity.
[0038] Furthermore, the negative pressure isolation storage and dispensing device provided by the present invention also includes a nitrogen gas path, which is connected to the exhaust filter assembly. The nitrogen gas path includes an exhaust valve 45 and a nitrogen port 48. By controlling the closing of the exhaust valve 45, nitrogen can be introduced into the exhaust filter assembly to blow away the impurities on the filter assembly.
[0039] Furthermore, in this embodiment, the negative pressure isolation storage and dispensing device has two sets of exhaust filter assemblies. One set of exhaust filter assemblies is installed on the reaction unit, which can quickly filter the gas in the cavity. The other set of exhaust filter assemblies is installed on the other side of the vacuum filter assembly to ensure the ventilation effect of the entire negative pressure isolation storage and dispensing device.
[0040] See Figure 2 At the top of the negative pressure isolation storage and dispensing device, an air inlet 49 is also provided. This air inlet can introduce airflow from the room into the upper part of the negative pressure isolation storage and dispensing device. Since this part mainly houses the exhaust fan 42, the design of this air inlet can be used to reduce the operating temperature of the exhaust fan 42. See also... Figure 2 A lighting lamp 121 is also provided on the top of the device.
[0041] See Figure 1 The fresh air component of the air circuit unit includes a fresh air valve 46 and an air intake filter 47, which are connected; in this embodiment, the air intake filter 47 is a single-stage air intake filter.
[0042] In addition, this embodiment introduces a vacuum filter assembly for the first time. The vacuum valve 43 is connected to the vacuum filter 44, and the vacuum valve 43 is connected to the vacuum generating unit, which includes a vacuum environment created by a vacuum pump. After the vacuum valve is connected to the vacuum environment created by the vacuum pump, the vacuum filter assembly can quickly generate negative pressure to adsorb the air in the negative pressure isolation storage and dispensing device, quickly remove particulate matter in the negative pressure isolation storage and dispensing device, avoid contamination of other raw materials by particulate matter, avoid errors or mistakes in experimental results, and quickly reduce operational risks.
[0043] See appendix Figure 1 and Figure 3 The water circuit unit of the negative pressure isolation storage and dispensing device includes a cleaning water circuit assembly disposed at the upper end of the cavity formed by the support and the transparent material, and a waste liquid water circuit assembly disposed on one side of the operating platform; the cleaning water circuit assembly includes a water pipe and at least one nozzle connected to the water pipe; the water pipe is connected to a cleaning water interface 51 and a compressed air interface 52, and a gas-liquid mixing chamber is provided between the water pipe and the nozzle connection to mix water and compressed air and increase the rinsing force; The gas and liquid introduced into the cleaning water interface 51 and the compressed air interface 52 are mixed in the mixing chamber, and the nozzle can spray high-pressure water to facilitate the cleaning of the negative pressure isolation storage and dispensing device.
[0044] Additionally, see Figure 1 The waste liquid water circuit assembly on one side of the operating platform is a waste liquid tank with an incline. Waste liquid can enter the waste liquid pipe through the waste liquid tank via the drain valve 54, and then be introduced into the waste liquid collection tank through the waste liquid pipe. In addition, a drain outlet 53 is provided at the reaction unit to discharge the wastewater from the reaction process and collect it into the waste liquid collection tank.
[0045] See also Figure 1A switch valve 55 is also provided on the front side of the negative pressure isolation storage and dispensing device. This switch valve is used to control the opening and closing of each liquid port on the operating platform. For example, it can control the opening and closing of the drain port 53.
[0046] In this embodiment, the negative pressure isolation storage and dispensing device also includes a detection and control unit; the detection and control unit can monitor the temperature, humidity, and particle size information of the sealed environment of the negative pressure isolation storage and dispensing device, and can also detect the working status of the gas path unit and the liquid path unit; in addition, the detection and control unit can also input parameters to control the active working mode of the negative pressure isolation storage and dispensing device and quickly maintain the microenvironment of the inner cavity of the negative pressure isolation storage and dispensing device.
[0047] The detection and control unit can also control the operation of the gas path unit and the drying unit. Specifically, the detection and control unit is connected to the actuators such as motors and valves in the gas path unit. By controlling the operation of the motors and valves through the actuators, the operating status of the gas path unit or the drying unit can be controlled. Figure 1 In the middle, the instrument panel 62 can display various indicators detected by the detection and control unit within the negative pressure isolation storage and dispensing device, see [link / reference]. Figure 3 The operation panel 63 can select or input relevant parameters to the control unit. In addition, the detection control unit also includes an RTP interface 61 located on the side of the negative pressure isolation storage and dispensing device. This interface can be connected to an external device to display the monitored indicators in the negative pressure isolation storage and dispensing device.
[0048] See Figure 1 Within the sealed cavity, there is an operating platform, a sealing cap 71, and an electronic scale 72. The equipment on the operating platform can be selected according to requirements. Below the device, an electrical cabinet 111 is installed to provide power to the equipment; and an integrated glove leak detector 81 is installed on the electrical cabinet. See also... Figure 3 A manual lifting door 131 is also provided between the storage unit and the stirring and mixing unit to isolate the space between the storage unit, the reaction unit and the stirring and mixing unit.
[0049] On the other hand, the present invention also provides a control method for a negative pressure isolation storage and dispensing device, wherein the negative pressure isolation storage and dispensing device includes a detection and control unit and an air circuit unit, wherein the air circuit unit includes an exhaust filter assembly, a vacuum filter assembly, and a fresh air assembly; The detection and control unit is electrically connected to the gas circuit unit, and the detection and control unit detects the temperature, humidity and particle size data in the cavity of the negative pressure isolation storage and dispensing device; See Figure 4 , Figure 4This is an operation flowchart involved in this embodiment, in which each process can be operated independently. For example, the detection control unit can detect the particle size change in the cavity of the negative pressure isolation storage and dispensing device; when the particle size increase rate is greater than the particle size change rate threshold, the detection control unit controls the exhaust filter assembly of the air circuit unit and increases the power of the exhaust fan (42) of the exhaust filter assembly, while closing the fresh air valve (46) of the fresh air assembly, and the detection control unit controls the vacuum valve (43) of the vacuum filter assembly of the air circuit unit to open, so as to quickly reduce the particulate matter in the environment of the cavity of the negative pressure isolation storage and dispensing device. The particle size change rate refers to the amount of particle size increase per unit time, directly reflecting the rate of change of particle size within the cavity. Generally, a larger change rate indicates a faster particle size increase within the cavity. This application is the first to use the particle size change rate as one of the adjustment factors to control related gas path units, achieving the effect of rapidly regulating the particle situation in the space.
[0050] Material separation and reaction operations, especially those involving high-temperature processing, are performed within a negative pressure isolation storage and dispensing device. This can easily cause the evaporation of solvents or raw materials, resulting in a rapid rise in particulate matter within the device's cavity. These rapidly rising particulate materials, scattered in the micro-environment, can easily contaminate other raw materials. Based on this particle size variation, this invention introduces a vacuum filter assembly into the device for the first time. By rapidly introducing a pressure differential, the pressure within the cavity is quickly reduced, achieving rapid filtration of particulate matter within the cavity.
[0051] In another embodiment, when the particle size increase is less than the particle size change rate threshold and the temperature exceeds a preset first temperature threshold, the detection control unit controls the exhaust filter assembly of the air circuit unit and increases the power of the exhaust fan (42) of the exhaust filter assembly, while opening the fresh air valve (46) of the fresh air assembly, so that the temperature of the fresh air entering the cavity of the negative pressure isolation storage and dispensing device is reduced; when the temperature rises from the first temperature threshold to the second temperature threshold, the detection control unit controls the vacuum valve (43) of the vacuum filter assembly of the air circuit unit to open, quickly reducing the temperature in the cavity of the negative pressure isolation storage and dispensing device; so that the temperature in the negative pressure isolation storage and dispensing device can be reduced quickly.
[0052] Furthermore, when the temperature inside the cavity of the negative pressure isolation storage and dispensing device drops to between the second temperature threshold and the first temperature threshold, the detection control unit controls the vacuum valve (43) of the vacuum filter assembly of the gas path unit to close, thereby adjusting the negative pressure state inside the cavity of the negative pressure isolation storage and dispensing device.
[0053] Furthermore, the first temperature threshold and the second temperature threshold can be set according to the operation and reaction requirements of the negative pressure isolation storage and dispensing device.
[0054] In another embodiment, when the increase in particle size is less than the particle size change rate threshold, the detection control unit can detect the humidity change in the cavity of the negative pressure isolation storage and dispensing device; and when the humidity is greater than the first humidity threshold, the detection control unit controls the exhaust filter assembly of the air circuit unit and increases the power of the exhaust fan (42) of the exhaust filter assembly, while opening the fresh air valve (46) of the fresh air assembly, so that fresh air enters the cavity of the negative pressure isolation storage and dispensing device to regulate the humidity; when the humidity rises from the first humidity threshold to the second humidity threshold, the detection control unit controls the vacuum valve (43) of the vacuum filter assembly of the air circuit unit to open, quickly reducing the humidity in the cavity of the negative pressure isolation storage and dispensing device; so that the temperature inside the negative pressure isolation storage and dispensing device can be quickly reduced.
[0055] When the humidity inside the cavity of the negative pressure isolation storage and dispensing device drops to between the second humidity threshold and the first humidity threshold, the detection and control unit controls the vacuum valve (43) of the vacuum filter assembly of the gas path unit to close, thereby adjusting the negative pressure state inside the cavity of the negative pressure isolation storage and dispensing device.
[0056] When the humidity inside the cavity of the negative pressure isolation storage and dispensing device drops below the first humidity threshold, the detection control unit controls the exhaust filter assembly of the air circuit unit and reduces the power of the exhaust fan (42) of the exhaust filter assembly. In another embodiment, when the particle size increase is less than the particle size change rate threshold and the particle size is greater than the first particle size threshold, the detection control unit controls the exhaust filter assembly of the air circuit unit and increases the power of the exhaust fan (42) of the exhaust filter assembly, while closing the fresh air valve (46) of the fresh air assembly to prevent fresh air from entering the device and quickly reduce the particles in the cavity of the negative pressure isolation storage and dispensing device; when the humidity rises from the first particle size threshold to the second particle size threshold, the detection control unit controls the vacuum valve (43) of the vacuum filter assembly of the air circuit unit to open, quickly reducing the particulate matter in the environment of the cavity of the negative pressure isolation storage and dispensing device; When the particle size in the cavity of the negative pressure isolation storage and dispensing device decreases to between the second particle size threshold and the first particle size threshold, the detection control unit controls the vacuum valve (43) of the vacuum filter assembly of the gas path unit to close, thereby adjusting the negative pressure state in the cavity of the negative pressure isolation storage and dispensing device.
[0057] When the humidity inside the cavity of the negative pressure isolation storage and dispensing device drops below the first particle size threshold, the detection control unit controls the fresh air valve (46) of the fresh air component of the air circuit unit to open and reduces the power of the exhaust fan (42) of the exhaust filter component to ensure the stability of the negative pressure inside the cavity of the negative pressure isolation storage and dispensing device.
[0058] The above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.
Claims
1. A negative pressure isolation storage and dispensing device, characterized in that, The device includes a reaction unit, a storage unit, a material mixing unit, a gas path unit, a liquid path unit, and a detection and control unit; The reaction unit is used for heat treatment reactions; The negative pressure isolation storage and dispensing device is assembled from a device support and a transparent substrate; and the device support and the transparent substrate form a sealed cavity; wherein, the transparent substrate is also provided with an operating glove hole (101), through which the sealed cavity can be entered for operation; The air passage unit is located at the upper end of the sealed cavity and is used to control the microenvironment inside the cavity. The air passage unit includes an exhaust filter assembly, a vacuum filter assembly, and a fresh air assembly.
2. The negative pressure isolation storage and dispensing device as described in claim 1, characterized in that, The exhaust filter assembly includes an exhaust filter (41) and an exhaust fan (42), and the exhaust filter (41) is connected to the exhaust fan (42); The fresh air assembly includes a fresh air valve (46) and an air intake filter (47). The exhaust filter assembly and fresh air assembly described herein exchange air within the sealed cavity and maintain a negative pressure state in the sealed environment.
3. The negative pressure isolation storage and dispensing device as described in claim 2, characterized in that, The vacuum filter assembly includes a vacuum valve (43) and a vacuum filter (44), wherein the vacuum valve (43) is connected to the vacuum filter (44) and the vacuum valve (43) is connected to the vacuum generating unit.
4. The negative pressure isolation storage and dispensing device as described in any one of claims 1-3, characterized in that, The reaction unit, storage unit, and material mixing unit are separated by a movable partition; The storage unit is mounted on the bracket of the negative pressure isolation storage and dispensing device, and the opening of the storage unit is located in the sealed cavity; The storage unit is a drying oven (31).
5. The negative pressure isolation storage and dispensing device as described in any one of claims 1-3, characterized in that, The mixing unit includes a power output section and a mixing head, wherein the mixing head is mounted on the bracket of the negative pressure isolation storage and dispensing device and is disposed inside a sealed cavity, and the power output section is disposed outside the bracket of the negative pressure isolation storage and dispensing device.
6. The negative pressure isolation storage and dispensing device according to any one of claims 1-3, characterized in that, The detection and control unit is electrically connected to the gas circuit unit. The detection and control unit can detect at least the temperature, humidity and particle size data inside the cavity of the negative pressure isolation storage and dispensing device.
7. A control method for a negative pressure isolation storage and dispensing device, applied to the device according to any one of claims 1-6, characterized in that, The detection control unit detects the particle size change in the cavity of the negative pressure isolation storage and dispensing device; when the particle size increase rate is greater than the particle size change rate threshold, the detection control unit controls and increases the power of the exhaust fan (42) of the exhaust filter assembly, while closing the fresh air valve (46) of the fresh air assembly and opening the vacuum valve (43) of the vacuum filter assembly to quickly reduce the particulate matter in the environment of the cavity of the negative pressure isolation storage and dispensing device.
8. The control method of the negative pressure isolation storage and dispensing device as described in claim 7, characterized in that: When the particle size increase rate is less than the particle size change rate threshold and the detected temperature exceeds the preset first temperature threshold, the detection control unit controls and increases the power of the exhaust fan (42) of the exhaust filter assembly, and at the same time opens the fresh air valve (46) of the fresh air assembly. And / or, when the temperature rises from the first temperature threshold to the second temperature threshold, the detection control unit controls the gas path unit to open the vacuum valve (43) of the vacuum filter assembly to extract the hot air in the sealed cavity and cool it down quickly. And / or, when the temperature drops to between the second temperature threshold and the first temperature threshold, the detection control unit controls the vacuum valve (43) of the closed vacuum filter assembly to adjust the negative pressure state in the cavity of the negative pressure isolation storage and dispensing device.
9. The control method for the negative pressure isolation storage and dispensing device as described in claim 7, characterized in that: When the particle size increase is less than the particle size change rate threshold and the detected humidity is greater than the first humidity threshold, the detection control unit controls and increases the power of the exhaust fan (42) of the exhaust filter assembly, and at the same time opens the fresh air valve (46) of the fresh air assembly; so that fresh air enters the cavity of the negative pressure isolation storage and dispensing device to regulate the humidity; And / or, when the humidity rises from the first humidity threshold to the second humidity threshold, the detection control unit controls the opening of the vacuum valve (43) of the vacuum filter assembly to quickly reduce the humidity in the cavity of the negative pressure isolation storage and dispensing device; And / or, when the humidity drops to between the second humidity threshold and the first humidity threshold, the detection control unit controls the vacuum valve (43) of the vacuum filter assembly to close, and adjusts the negative pressure state in the cavity of the negative pressure isolation storage and dispensing device; And / or when the humidity drops to a first humidity threshold, the detection control unit controls and reduces the power of the exhaust fan (42) of the exhaust filter assembly.
10. The control method for the negative pressure isolation storage and dispensing device as described in claim 7, characterized in that: When the particle size increase is less than the particle size change rate threshold and the particle size is greater than the first particle size threshold, the detection control unit controls and increases the power of the exhaust fan (42) of the exhaust filter assembly, and at the same time closes the fresh air valve (46) of the fresh air assembly to prevent fresh air from entering the device and quickly reduce the particles in the cavity of the negative pressure isolation storage and dispensing device. And / or, when the humidity rises from the first particle size threshold to the second particle size threshold, the detection control unit controls the vacuum valve (43) of the vacuum filter assembly to open, quickly reducing the negative pressure to isolate particulate matter in the cavity of the storage and dispensing device. When the particle size decreases to between the second particle size threshold and the first particle size threshold, the detection control unit controls the vacuum valve (43) of the closed vacuum filter assembly to close, and adjusts the negative pressure state in the cavity of the negative pressure isolation storage and dispensing device.