Cream for treating erythroderma type psoriasis and preparation method thereof

Abstract

The invention discloses a cream for treating erythroderma type psoriasis and a preparation method thereof, and belongs to the technical field of psoriasis drugs, the cream is prepared from the following raw materials by weight: 20-50 parts of cassia alata, 5-15 parts of prepared myrrh, 2-8 parts of raw rehmannia root, 40-160 parts of water, 40-50 parts of an emulsifier, and 0.05-0.1 part of a preservative. The preparation method comprises the following steps: decocting the cassia alata, the prepared myrrh and the radix rehmanniae recen in water, and then fishing out the medicinal materials to obtain medicine slurry; and mixing the medicine slurry, the emulsifier and the preservative, adding into an emulsifying machine, and emulsifying to obtain the product. The formula can be used for treating erythroderma type psoriasis, and the external emulsifiable paste for psoriasis has the effects of inhibiting various fungi and viruses, removing heat to cool blood, astringing and promoting tissue regeneration, inhibiting epidermal cell proliferation, slowing down epidermal metabolism cycle speed, promoting keratinogenesis, inhibiting sebum secretion and inhibiting the growth environment of bacteria and fungi. The inflammation cells are eliminated; the itching is relieved, and the like.

Description

Technical Field

[0001] This invention belongs to the field of psoriasis drug technology, and relates to a cream for treating erythrodermic psoriasis and its preparation method. Background Technology

[0002] Psoriasis, also known as silver scale disease, commonly occurs on the extensor surfaces of the limbs, scalp, sacrum, and trunk, often in symmetrical areas. The main lesions are erythematous plaques and scaling, causing itching. While it doesn't seriously affect health, it can be very bothersome to a person's appearance. Psoriasis can resolve spontaneously, but it tends to recur, lasting for years or even decades. It is not contagious. This disease is easy to diagnose but difficult to cure.

[0003] There are two common types of psoriasis: plaque psoriasis and erythrodermic psoriasis. Plaque psoriasis is characterized by rashes that typically appear on the scalp, trunk, and extensor surfaces of the limbs. These rashes are red papules that gradually enlarge and merge into plaques or patches, covered with thick, irregularly shaped, silvery-white scales. Erythrodermic psoriasis, on the other hand, can occur anywhere on the body, but is most common on the back, limbs, and extensor surfaces. It presents as diffuse redness of the skin, with abundant bran-like, scaly, and infiltrated swelling.

[0004] As people pay more attention to psoriasis as a health condition, a wide variety of psoriasis medications are emerging on the market.

[0005] Currently, there are various products available, including psoriasis medications, with varying effects. Some may contain hormones, which can cause side effects such as dependence during use.

[0006] Existing psoriasis medications contain hormones that have side effects on the human body. Therefore, how to provide a safe, side-effect-free cream for treating erythrodermic psoriasis and its preparation method is a problem that urgently needs to be solved by those in the field. Summary of the Invention

[0007] In view of this, the present invention provides a cream for treating erythrodermic psoriasis and a method for preparing the same.

[0008] To achieve the above objectives, the present invention adopts the following technical solution:

[0009] A cream for treating erythrodermic psoriasis is prepared from the following raw materials in the indicated weight percentages: 20-50 parts of Cassia tora, 5-15 parts of processed myrrh, 2-8 parts of Rehmannia glutinosa, 40-160 parts of water, 40-50 parts of emulsifier, and 0.05-0.1 parts of preservative.

[0010] The beneficial effects of this invention: As a topical cream for psoriasis, this invention has the effects of inhibiting various fungi and viruses, clearing heat and cooling blood, astringing and promoting tissue regeneration, inhibiting epidermal cell proliferation, slowing down the epidermal metabolic cycle, promoting keratinization, inhibiting sebum secretion, inhibiting the growth environment of bacteria and fungi, and dissipating inflammatory cells and relieving itching.

[0011] The combination of cassia seed, processed myrrh, and rehmannia root is highly effective in treating erythrodermic psoriasis. Its main effects on erythrodermic psoriasis include clearing heat and cooling the blood, stopping bleeding, antibacterial and anti-inflammatory properties, controlling pathogens on the skin, reducing pain and itching, promoting skin repair, and acting as an antiviral and antifungal agent, inhibiting the reproduction of viruses and bacteria. This invention has no side effects.

[0012] Among them, senna seed pods have antibacterial and anti-inflammatory effects, effectively controlling pathogens on the skin, relieving pain and itching, and reducing peeling and redness. In addition, senna seed pods also have anti-inflammatory and antibacterial properties, which can inhibit the reproduction of viruses and bacteria and reduce inflammation.

[0013] Myrrh has antibacterial, anti-inflammatory, anti-swelling, and tissue-regenerating properties, and can accelerate the healing of skin ulcers.

[0014] Rehmannia glutinosa: Clears heat, cools the blood, and stops bleeding.

[0015] This formula can treat erythrodermic psoriasis, which can occur anywhere on the body, but is most common on the back and extensor surfaces of the limbs.

[0016] Furthermore, the emulsifier mentioned above is glyceryl monostearate.

[0017] The beneficial effects of adopting the above-mentioned further technical solutions are: ease of use and better skin absorption.

[0018] Furthermore, the aforementioned preservative is ethylparaben.

[0019] The beneficial effects of adopting the above-mentioned further technical solution are as follows: the addition of 0.05-0.1 parts of preservative ensures that the shelf life of erythrodermic psoriasis reaches 24 months.

[0020] This invention also provides a method for preparing a cream for treating erythrodermic psoriasis, comprising the following steps:

[0021] (1) Weigh out the raw materials according to the above-mentioned cream for treating erythrodermic psoriasis;

[0022] (2) Boil cassia seed, prepared myrrh and raw rehmannia root in water, then remove the herbs to obtain a medicinal liquid;

[0023] (3) Mix the medicine, emulsifier and preservative and add them to the emulsifier to emulsify, and obtain the above-mentioned cream for treating erythrodermic psoriasis.

[0024] Furthermore, in step (2), the above-mentioned cooking process is as follows: first boil at 110-120℃, then simmer at 80-90℃ for 20-30 minutes.

[0025] The beneficial effects of adopting the above-mentioned further technical solutions are: it ensures the success rate of the medicine and prevents it from burning.

[0026] Furthermore, in step (3), the speed of the emulsifier is 30-60 rpm and the emulsification time is 30-60 minutes.

[0027] The beneficial effects of adopting the above-mentioned further technical solutions are: this rotation speed and time produce the best emulsification effect. Detailed Implementation

[0028] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0029] Example 1

[0030] A method for preparing a cream for treating erythrodermic psoriasis includes the following steps:

[0031] (1) Weigh out 20 kg of Cassia tora, 5 kg of prepared myrrh, 2 kg of Rehmannia glutinosa, 40 kg of water, 40 kg of glyceryl monostearate, and 0.05 kg of ethylparaben.

[0032] (2) Add water to cassia seed, prepared myrrh and raw rehmannia root and boil. First boil at 110℃, then boil at 80℃ for 20 minutes. Then remove the herbs and get the medicinal liquid.

[0033] (3) Mix the medicine, emulsifier and preservative and add them to the emulsifier for emulsification. The speed of the emulsifier is 30 rpm and the emulsification time is 30 minutes to obtain the cream for treating erythrodermic psoriasis.

[0034] Example 2

[0035] A method for preparing a cream for treating erythrodermic psoriasis includes the following steps:

[0036] (1) Weigh out 30 kg of Cassia tora, 10 kg of prepared myrrh, 6 kg of Rehmannia glutinosa, 100 kg of water, 45 kg of glyceryl monostearate, and 0.07 kg of ethylparaben.

[0037] (2) Add water to cassia seed, prepared myrrh and raw rehmannia root and boil. First boil at 115℃, then boil at 85℃ for 25 minutes. Then remove the herbs and get the medicinal liquid.

[0038] (3) Mix the medicine, emulsifier and preservative and add them to the emulsifier for emulsification. The speed of the emulsifier is 40 revolutions / minute and the emulsification time is 40 minutes to obtain the cream for treating psoriasis vulgaris.

[0039] Example 3

[0040] A method for preparing a cream for treating erythrodermic psoriasis includes the following steps:

[0041] (1) Weigh out 42 kg of Cassia tora, 10 kg of processed myrrh, 4 kg of Rehmannia glutinosa, 160 kg of water, 45 kg of glyceryl monostearate, and 0.1 kg of ethylparaben.

[0042] (2) Add water to cassia seed, prepared myrrh and raw rehmannia root and boil. First boil at 120℃, then boil at 90℃ for 30 minutes. Then remove the herbs and get the medicinal liquid.

[0043] (3) Mix the medicine, emulsifier and preservative and add them to the emulsifier for emulsification. The speed of the emulsifier is 60 revolutions / minute and the emulsification time is 60 minutes to obtain the cream for treating psoriasis vulgaris.

[0044] Effect test

[0045] 1. Typical Cases

[0046] Instructions for use: Apply as needed, once a day. The longer the ointment remains on the skin, the better the absorption. During treatment, avoid certain foods and medications, including any traditional Chinese medicine. Maintain good hygiene and exercise regularly.

[0047] Case 1: Mr. Cai, male, 59 years old, a psoriasis patient for 18 years.

[0048] Case Analysis: The patient presented with moderate erythrodermic psoriasis on the back. Example 1 cream was applied once daily. Itching disappeared after half a month of treatment, the number of lesions significantly decreased after 20 days, and the condition was completely cured after two months. Before complete recovery, three small, rice-grain-sized spots reappeared on the body, requiring further treatment. The condition did not recur for two years after recovery, and no dietary restrictions were necessary. A total of 50 ml of cream was used over two months.

[0049] Case 2: Ms. Chen, 22 years old, a psoriasis patient for 5 years.

[0050] Case Analysis: Mild erythrodermic psoriasis was observed on the back and limbs. The patient was treated with the cream described in Example 2 once daily. After initial improvement, treatment was delayed, and the patient recovered after five months of treatment, using a total of 60 ml of cream over five months. Itching disappeared after one week of treatment, and the number of lesions significantly decreased. There were no recurrences on the back and limbs, and the patient remained relapse-free for eight months after recovery.

[0051] Case 3: Ms. Chen, 59 years old, has been a psoriasis patient for more than ten years.

[0052] Case Analysis: The patient presented with moderate erythrodermic psoriasis on the back and limbs. The patient applied the cream described in Example 3 once daily, and recovered completely within six months. A total of 180 ml of cream was used over the six months. Itching disappeared after 10 days of treatment, and the number of lesions significantly decreased after one month. The patient experienced two recurrences of 7-8 lesions on the back and limbs before complete recovery, but there was no recurrence for six months after recovery.

[0053] Case 4: Mr. Cai, male, 40 years old, a psoriasis patient for 11 years.

[0054] Case Analysis: The patient presented with erythrodermic psoriasis on the back and limbs. The patient applied the cream described in Example 3 once a day. After five months of treatment, the condition was cured, but the relapse period has not yet passed; it has only recurred once, and the patient continues to use the medication.

[0055] 2. Application method: Apply as needed, once a day. The longer the ointment remains on the skin, the better the absorption effect. During the treatment period, avoid certain foods and medications, and maintain good hygiene through regular exercise.

[0056] This invention was used in twenty clinical cases in Cambodia. The patients were aged 17 to 38 years old, and all twenty cases were male. The patients recovered one after another within five months.

[0057] 3. Application method: Apply as needed, once a day, using only Cassia Seed Cream. The longer the cream remains on the skin, the better the absorption. During treatment, avoid certain foods and medications, and maintain good hygiene through regular exercise.

[0058] In 2022, this invention conducted 400 clinical cases, with patients aged 14-78 years, including 313 men and 87 women. The results after six months of case studies showed that 50% of patients were cured, mainly those with mild, moderate, and young illnesses; 10% of patients showed significant improvement, and the medication supply was insufficient; and 40% of patients showed no significant improvement. The severe patients were older and had been ill for many years, with most having had the disease for 20 to 40 years. They did not take it seriously, did not trust it, and did not use it properly, resulting in insufficient medication and requiring longer treatment times for severe patients.

[0059] Conclusion: Mild to moderate erythrodermic psoriasis patients, mainly affecting the back and limbs, typically recover within 2 months of medication. Moderate to severe cases recover within 6 months, and moderate to severe cases recover within 8 months.

[0060] 4. Animal experiments:

[0061] The cream from Example 1 was applied to the skin diseases on the bodies and cervical spines of three dogs and two cats respectively. The skin diseases on the dogs were completely cleared up in 15-20 days.

[0062] 5. We have applied for two patents for psoriasis, psoriasis vulgaris and psoriasis erythroderma. Our cases have confirmed that only by using both psoriasis vulgaris and psoriasis erythroderma creams together can the virus in psoriasis patients be suppressed, and recurrence will not occur after recovery.

[0063] The description of the disclosed embodiments enables those skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A cream for treating erythrodermic psoriasis, characterized in that, It is prepared from the following raw materials in parts by weight: 20-50 parts of winged cassia seed, 5-15 parts of prepared myrrh, 2-8 parts of raw rehmannia root, 40-160 parts of water, 40-50 parts of emulsifier, and 0.05-0.1 parts of preservative.

2. The cream for treating erythrodermic psoriasis according to claim 1, characterized in that, The emulsifier is glyceryl monostearate.

3. The cream for treating erythrodermic psoriasis according to claim 1, characterized in that, The preservative is ethylparaben.

4. A method for preparing a cream for treating erythrodermic psoriasis, characterized in that, Includes the following steps: (1) Weigh out each of the raw materials for the cream for treating erythrodermic psoriasis according to any one of claims 1-3; (2) Boil cassia seed, prepared myrrh and raw rehmannia root in water, then remove the herbs to obtain a medicinal liquid; (3) Mix the medicated paste, emulsifier and preservative and add them to an emulsifier for emulsification to obtain the cream for treating erythrodermic psoriasis.

5. The method for preparing a cream for treating erythrodermic psoriasis according to claim 4, characterized in that, In step (2), the cooking process is as follows: first boil at 110-120℃, then simmer at 80-90℃ for 20-30 minutes.

6. The method for preparing a cream for treating erythrodermic psoriasis according to claim 4, characterized in that, In step (3), the speed of the emulsifier is 30-60 rpm and the emulsification time is 30-60 minutes.