Rapid and uniform rewarming microwave heating system and heating method for large-scale organs after long-time low-temperature preservation
By dynamically adjusting the internal and external temperatures of organs through a microwave heating system, the problem of uneven temperature during organ rewarming is solved, achieving rapid and uniform rewarming and reducing organ damage.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-11-27
- Publication Date
- 2026-04-07
AI Technical Summary
In existing technologies, uneven temperatures inside and outside organs during organ rewarming can lead to organ damage, and traditional heating methods are inefficient and difficult to achieve long-term preservation.
A microwave heating system is used, which uses a microwave signal generator, microwave power amplifier, coupler, resonant cavity, spectrum analyzer and temperature detection device, combined with a control unit to dynamically adjust microwave parameters and ensure uniform heating inside and outside the organ.
It achieves temperature uniformity during organ rewarming, shortens rewarming time, reduces organ damage, and improves heating efficiency.
Smart Images
Figure CN121815470A_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of cryopreservation technology, and in particular to a microwave heating system and method for rapid and uniform rewarming after long-term cryopreservation of large-scale organs. Background Technology
[0002] Organ transplantation is the preferred and effective treatment for end-stage organ failure. Currently, the longest preservation time for different organs using commonly used static preservation methods is 4-36 hours, which limits organ transplantation by time and location. Lowering the temperature can effectively slow down the biological metabolic level to achieve long-term preservation, but organs are extremely susceptible to "recrystallization" damage during rewarming. How to rewarm quickly and evenly is the key to successfully achieving long-term organ preservation.
[0003] However, most rewarming methods in related technologies rely on heat conduction between the organ and the antifreeze. Due to the low heat transfer coefficients of both, the warming rate is insufficient, resulting in a large temperature difference between the inside and outside of the organ, which can cause damage to the organ during the rewarming phase. Summary of the Invention
[0004] The purpose of this application is to provide a microwave heating system and method for rapid and uniform rewarming of large-scale organs after long-term cryopreservation. By using microwave heating, the temperature inside and outside the organ is made uniform during the rewarming process, which not only shortens the rewarming time of the organ, but also reduces the damage to the organ during the rewarming process.
[0005] This application provides a microwave heating system for rapid and uniform rewarming after long-term cryopreservation of large-scale organs, comprising: The system comprises a microwave signal generator, a microwave power amplifier, a coupler, a resonant cavity, a spectrum analyzer, and a temperature detection device. The microwave signal generator and microwave power amplifier generate microwave energy of a desired frequency and power, and input this energy into the resonant cavity via the coupler to heat an object within the cavity. The spectrum analyzer monitors the forward microwave power of the coupler and the reflected microwave signal within the resonant cavity, and transmits the monitored forward microwave power and reflected microwave signal to a control unit. The temperature detection device monitors the internal and surface temperatures of the heated object and transmits these temperatures to the control unit. The control unit dynamically adjusts the output parameters of the microwave signal generator and the microwave power amplifier based on a preset heating temperature curve and real-time feedback data until the temperature of the heated object reaches the set temperature. The real-time feedback data includes the forward microwave power and reflected microwave signal fed back by the spectrum analyzer, and the internal and surface temperatures of the heated object fed back by the temperature detection device. The output parameters include output power and / or output frequency.
[0006] Optionally, the output terminal of the microwave power amplifier is connected to the input terminal of the coupler; the output terminal of the coupler is connected to the input terminal of the resonant cavity; and the spectrum analyzer is connected to the coupling terminal and the reflection terminal of the coupler respectively.
[0007] Optionally, the spectrum analyzer is specifically used to monitor the forward microwave power of the coupler through the coupling end and to monitor the reflected microwave signal in the resonant cavity through the reflecting end; wherein the reflected microwave signal includes at least one of the following: the frequency purity of the reflected microwave, the harmonic components of the reflected microwave, and the spurious components of the reflected microwave.
[0008] Optionally, the resonant cavity includes: a waveguide port, an observation window, a disassembly interface, and a heating cavity; the resonant cavity is used to realize multiple reflections and superpositions of the microwave field to improve the uniformity of the microwave field in the heating region.
[0009] Optionally, the temperature detection device includes: a fiber optic thermometer and an infrared thermometer; the fiber optic thermometer is used to measure the internal temperature of the heated object; the infrared thermometer is used to measure the surface temperature of the heated object.
[0010] Optionally, the system further includes: a network analyzer; the network analyzer is used to connect to the resonant cavity in calibration mode and calibrate the resonant cavity; wherein, calibrating the resonant cavity includes: performing impedance matching on the resonant cavity and tuning the resonant cavity.
[0011] Optionally, the network analyzer is specifically used to measure and diagnose the input impedance, reflection coefficient, and transmission characteristics of the resonant cavity, and to calibrate the resonant cavity based on the input impedance, reflection coefficient, and transmission characteristics of the resonant cavity.
[0012] Optionally, the control unit is specifically used to send a signal using the network analyzer and measure the reflected signal of the resonant cavity during the preparation stage; the control unit is also specifically used to calculate the resonant frequency based on the reflected signal and use the resonant frequency as a reference frequency during the heating process.
[0013] This application also provides a microwave heating method for cryopreservation of large-scale organs, comprising: Obtain a preset heating temperature curve and a reference frequency; based on the preset heating temperature curve and real-time feedback data, dynamically adjust the output parameters of the microwave signal generator and the microwave power amplifier until the temperature of the heated object reaches the set temperature; wherein, the real-time feedback data includes: the forward microwave power and reflected microwave signal fed back by the spectrum analyzer, and the internal temperature and surface temperature of the heated object fed back by the temperature detection device; the output parameters include: output power, and / or, output frequency.
[0014] Optionally, the method further includes, in the preparation stage, dynamically adjusting the output parameters of the microwave signal generator and the microwave power amplifier based on the preset heating temperature curve and real-time feedback data until the temperature of the heated object reaches the set temperature, the method further includes: in the preparation stage, using the network analyzer to send a signal and measuring the reflected signal of the resonant cavity; calculating the resonant frequency based on the reflected signal, and using the resonant frequency as a reference frequency during the heating process.
[0015] This application also provides a computer program product, including a computer program / instructions that, when executed by a processor, implement the steps of the rapid and uniform rewarming microwave heating method for long-term cryopreservation of large-scale organs as described above.
[0016] This application also provides an electronic device, including a memory, a processor, and a computer program stored in the memory and executable on the processor, wherein the processor executes the program to implement the steps of the microwave heating method for rapid and uniform rewarming after long-term cryopreservation of large-scale organs as described above.
[0017] This application also provides a computer-readable storage medium having a computer program stored thereon, which, when executed by a processor, implements the steps of the microwave heating method for rapid and uniform rewarming after long-term cryopreservation of large-scale organs as described above.
[0018] This application provides a microwave heating system and method for rapid and uniform rewarming after long-term cryopreservation of large-scale organs. The system includes: a microwave signal generator, a microwave power amplifier, a coupler, a resonant cavity, a spectrum analyzer, and a temperature detection device. The microwave signal generator and microwave power amplifier are used to generate microwave energy of the required frequency and power, and input the microwave energy into the resonant cavity through the coupler to heat the object inside the resonant cavity. The spectrum analyzer is used to monitor the forward microwave power of the coupler and the reflected microwave signal inside the resonant cavity, and send the monitored forward microwave power and reflected microwave signal to the control unit. The temperature detection device is used to monitor the internal and surface temperatures of the heated object and send these temperatures to the control unit. The control unit dynamically adjusts the output parameters of the microwave signal generator and the microwave power amplifier based on a preset heating temperature curve and real-time feedback data until the heated object reaches the set temperature. The real-time feedback data includes the forward microwave power and reflected microwave signal fed back by the spectrum analyzer, and the internal and surface temperatures of the heated object fed back by the temperature detection device. The output parameters include output power and / or output frequency. Thus, by using microwave heating, the temperature inside and outside the organ is made uniform during the rewarming process, which not only shortens the rewarming time but also reduces damage to the organ during the rewarming process. Attached Figure Description
[0019] To more clearly illustrate the technical solutions in this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.
[0020] Figure 1 This is a schematic diagram of the structure of the microwave heating system for rapid and uniform rewarming after long-term cryopreservation of large-scale organs provided in this application. Figure 2 This is a schematic diagram of the temperature measurement method of the temperature detection device provided in this application; Figure 3 This is a flowchart illustrating the microwave heating method for rapid and uniform rewarming after long-term cryopreservation of large-scale organs provided in this application. Figure 4 This is a schematic diagram of the structure of the electronic device provided in this application. Detailed Implementation
[0021] To make the objectives, technical solutions, and advantages of this application clearer, the technical solutions of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.
[0022] The terms "first," "second," etc., used in the specification and claims of this application are used to distinguish similar objects and not to describe a specific order or sequence. It should be understood that such use of data can be interchanged where appropriate so that embodiments of this application can be implemented in orders other than those illustrated or described herein, and the objects distinguished by "first," "second," etc., are generally of the same class and the number of objects is not limited; for example, a first object can be one or more. Furthermore, in the specification and claims, "and / or" indicates at least one of the connected objects, and the character " / " generally indicates that the preceding and following objects are in an "or" relationship.
[0023] The following provides a detailed explanation of the technical terms used in the embodiments of this application: Impedance matching: In microwave engineering, the fundamental goal of impedance matching is to ensure maximum power transfer of microwave energy from the source (power amplifier) to the load (the material-filled resonant cavity) and minimize energy reflection. At the reflecting end: The microwave power amplifier has a fixed, optimal output impedance (typically 50 ohms). At the load end: The resonant cavity and the heated organ together constitute a load impedance. This impedance is complex, unknown, and dynamically changing because the dielectric properties of the organ vary drastically with temperature, moisture content, and tissue state.
[0024] For precision applications like large-scale organ rewarming, impedance matching is not just about "improving efficiency," but also crucial for safety and success rates, primarily in the following ways: 1. Ensure accurate and stable heating power. If there is a mismatch, a large amount of power will be reflected, and the actual power entering the organ will be far lower than the set value and difficult to predict. This makes it impossible for the system to strictly control the temperature according to the "preset heating curve", which may lead to rewarming failure or organ damage.
[0025] 2. Protect expensive microwave sources Reflected microwave energy can return and impact fragile microwave power amplifiers, causing them to overheat, lose efficiency, or even suffer permanent damage. Proper matching is essential for protecting system hardware.
[0026] 3. Ensure even heating and avoid hot spots. Severe mismatch can lead to distortion and instability of the electromagnetic field modes within the resonant cavity, easily forming "hot spots" and causing localized overheating and necrosis of organs. Stable matching is fundamental to maintaining "microwave field quality" and uniform heating.
[0027] 4. Achieve true closed-loop control A key advantage of this system is its multi-parameter feedback closed-loop control. The reflected power measured by the coupler is the most direct real-time indicator for evaluating the matching state. The central control unit uses this indicator to trigger "real-time impedance matching adjustment," ensuring the system always operates at its optimal state.
[0028] To address the technical problem of uneven internal and external temperatures during organ rewarming in related technologies, this application provides a microwave heating system for rapid and uniform rewarming of large-scale organs after long-term cryopreservation. This system utilizes microwave heating principles to heat the organ. Polar molecules in the resonant cavity change from their original thermal motion state to abruptly aligning themselves according to the electromagnetic field direction, generating frictional heat. This electromagnetic heat is converted into internal heat within the medium, raising its temperature. Water molecules are highly polar and have a strong ability to absorb microwaves. Since biological tissues are 70% water, microwave heating is effective for heating biological tissues. The main advantages are: electromagnetic waves can provide greater energy, resulting in a faster rewarming rate; and electromagnetic waves heat from within the object, solving the problem of uneven heating in traditional methods. These advantages facilitate rapid and uniform rewarming of organs and reduce damage during long-term preservation.
[0029] The heating system in this embodiment includes a pose adjustment mechanism located inside or at the bottom of the resonant cavity. This mechanism is connected to a support platform on which the object to be heated is placed, driving the platform to undergo periodic or non-periodic spatial pose changes during the heating process. These spatial pose changes include, but are not limited to, one or more combinations of rotation about its own axis, revolution relative to the central axis of the resonant cavity, and vertical lifting motion. By introducing these movements, the relative position and angle of the heated object in the electromagnetic field are dynamically changed, allowing different parts of the object to be exposed more uniformly to areas with different field strengths. This effectively compensates for the inherent non-uniformity of the electromagnetic field distribution within the resonant cavity, significantly improving the uniformity of heating.
[0030] The following description, in conjunction with the accompanying drawings, details the microwave heating system for rapid and uniform rewarming after long-term cryopreservation of large-scale organs provided in this application, through specific embodiments and application scenarios.
[0031] like Figure 1As shown in the illustration, this application provides a microwave heating system for rapid and uniform rewarming after long-term cryopreservation of large-scale organs. The system includes: a microwave signal generator, a microwave power amplifier, a coupler, a resonant cavity, a spectrum analyzer, and a temperature detection device. The microwave signal generator adjusts its power and frequency, the amplifier adjusts its amplification factor, and the coupler separates the signals for detection.
[0032] For example, the microwave signal generator and microwave power amplifier are used to generate microwave energy of the required frequency and power, and input the microwave energy into the resonant cavity through the coupler to heat the object to be heated in the resonant cavity.
[0033] For example, the spectrum analyzer is used to monitor the forward microwave power of the coupler and the reflected microwave signal in the resonant cavity, and to send the monitored forward microwave power and reflected microwave signal to the control unit.
[0034] For example, the temperature detection device is used to monitor the internal temperature and surface temperature of the heated object, and send the internal temperature and surface temperature of the heated object to the control unit.
[0035] For example, the control unit is used to dynamically adjust the output parameters of the microwave signal generator and the microwave power amplifier based on a preset heating temperature curve and real-time feedback data until the temperature of the heated object reaches the set temperature.
[0036] The real-time feedback data includes: the forward microwave power and reflected microwave signal fed back by the spectrum analyzer, and the internal temperature and surface temperature of the heated object fed back by the temperature detection device; the output parameters include: output power, and / or, output frequency.
[0037] It should be noted that microwave power amplifiers adjust their output power by adjusting the power amplification factor.
[0038] For example, the microwave signal generator and microwave power amplifier are used to generate microwave energy of the required frequency and power, and their output power can be adjusted in real time and precisely according to the instructions of the control system. The coupler connects the microwave power amplifier and the resonant cavity, and is used to deliver microwave energy into the resonant cavity, while also having a directional coupling function to measure the forward microwave power and the reflected microwave power.
[0039] For example, such as Figure 1As shown, the output terminal of the microwave power amplifier is connected to the input terminal of the coupler; the output terminal of the coupler is connected to the input terminal of the resonant cavity; the spectrum analyzer is connected to the coupling terminal and the reflection terminal of the coupler respectively. The coupler connects the microwave power amplifier and the resonant cavity, and is used to efficiently couple microwave energy into the resonant cavity, while also having a directional coupling function to measure forward microwave power and reflected microwave power.
[0040] It should be noted that the function of the above-mentioned coupling end is to measure the forward microwave power. The principle is that a portion of the microwave energy input into the coupler will be output from the coupling end. By detecting the microwave power output from the coupling end, the forward microwave power output by the coupler can be calculated.
[0041] For example, the spectrum analyzer is specifically used to monitor the forward microwave power of the coupler through the coupling end and to monitor the reflected microwave signal in the resonant cavity through the reflecting end; wherein the reflected microwave signal includes at least one of the following: the frequency purity of the reflected microwave, the harmonic components of the reflected microwave, and the spurious components of the reflected microwave.
[0042] For example, the spectrum analyzer is connected to the diagnostic port of the coupler (usually the reflected power measurement port or a dedicated probe) to monitor in real time the frequency purity, harmonics and spurious components of the reflected microwave signal due to mismatch, ensuring the stable operation of the microwave source and the quality of the microwave field.
[0043] Specifically, the resonant cavity includes: a waveguide port, an observation window, a disassembly interface, and a heating cavity; the resonant cavity is used to realize multiple reflections and superpositions of the microwave field to improve the uniformity of the microwave field in the heating area.
[0044] For example, such as Figure 1 As shown, the resonant cavity, as the heating body, includes a waveguide port, observation window, disassembly interface, heating cavity, etc., to accommodate the object being heated. Through its structural design, it realizes multiple reflections and superpositions of the microwave field in order to improve the uniformity of the microwave field in the heating area.
[0045] Specifically, the temperature detection device includes: a fiber optic thermometer and an infrared thermometer; the fiber optic thermometer is used to measure the internal temperature of the heated object; the infrared thermometer is used to measure the surface temperature of the heated object.
[0046] For example, such as Figure 1 As shown, fiber optic thermometers and infrared thermometers provide data on the internal and surface temperatures of the heated object.
[0047] Specifically, the system further includes: a network analyzer; the network analyzer is used to connect to the resonant cavity in calibration mode and calibrate the resonant cavity; wherein, calibrating the resonant cavity includes: performing impedance matching on the resonant cavity and tuning the resonant cavity.
[0048] For example, the network analyzer is connected to the resonant cavity in system debugging or periodic calibration mode to accurately measure and diagnose the input impedance, reflection coefficient, and transmission characteristics of the resonant cavity, providing accurate data support for resonant cavity matching and tuning. Specifically, the network analyzer is used to measure and diagnose the input impedance, reflection coefficient, and transmission characteristics of the resonant cavity, and to complete the calibration of the resonant cavity based on these parameters.
[0049] Specifically, the control unit is used to send a signal using the network analyzer and measure the reflected signal of the resonant cavity during the preparation stage; the control unit is also used to calculate the resonant frequency based on the reflected signal and use the resonant frequency as a reference frequency during the heating process.
[0050] For example, such as Figure 1 As shown, the system delivers microwave energy into the resonant cavity via a coupler. A spectrum analyzer monitors the forward and reflected power in real time to assess the matching status. Figure 2 As shown, fiber optic thermometers and infrared thermometers provide internal and surface temperature data of the heated object. A spectrum analyzer monitors the quality of the microwave field in real time. All diagnostic and temperature data are collected at the central control unit. Based on a preset heating curve and real-time feedback data, the control unit dynamically adjusts the output power of the microwave power amplifier and performs real-time impedance matching adjustment (adjusting the structural properties, size, and materials of the resonant cavity), thereby achieving closed-loop, high-precision, and high-stability control of the heating process.
[0051] The microwave heating system for rapid and uniform rewarming after long-term cryopreservation of large-scale organs provided in this application has the following beneficial effects: 1. High-precision temperature control: By combining fiber optic thermometers and infrared thermometers, comprehensive and real-time monitoring of the internal and surface temperatures of the heated object is achieved, avoiding local overheating and thermal runaway. 2. High stability and field quality diagnosis: The introduction of a spectrum analyzer enables the system to monitor the frequency drift and spurious emissions of the microwave source in real time, ensuring the stability of the input microwave field. 3. Optimized matching and diagnostic capabilities: The coupler provides real-time feedback of reflected power; and the application of a network analyzer provides accurate impedance matching data on microwave transmission and resonant cavity characteristics, helping the system to quickly and efficiently reach its optimal state. 4. Integrated closed-loop control: By tightly integrating power regulation, field quality monitoring, and multi-dimensional temperature measurement, highly intelligent closed-loop control is achieved, significantly improving the uniformity, energy efficiency, and process reproducibility of microwave heating.
[0052] This application provides a microwave heating system for rapid and uniform rewarming after long-term cryopreservation of large-scale organs, comprising: a microwave signal generator, a microwave power amplifier, a coupler, a resonant cavity, a spectrum analyzer, and a temperature detection device. The microwave signal generator and microwave power amplifier generate microwave energy of the required frequency and power, and input the microwave energy into the resonant cavity through the coupler to heat the object within the resonant cavity. The spectrum analyzer monitors the forward microwave power of the coupler and the reflected microwave signal within the resonant cavity, and sends the monitored forward microwave power and reflected microwave signal to a control unit. A temperature detection device is used to monitor the internal and surface temperatures of the heated object and send these temperatures to the control unit. The control unit dynamically adjusts the output parameters of the microwave signal generator and the microwave power amplifier based on a preset heating temperature curve and real-time feedback data until the temperature of the heated object reaches the set temperature. The real-time feedback data includes the forward microwave power and reflected microwave signal fed back by the spectrum analyzer, and the internal and surface temperatures of the heated object fed back by the temperature detection device. The output parameters include output power and / or output frequency. Thus, by using microwave heating, the temperature inside and outside the organ is made uniform during the rewarming process, which not only shortens the rewarming time but also reduces damage to the organ during the rewarming process.
[0053] The following description, in conjunction with the accompanying drawings, details the microwave heating method for rapid and uniform rewarming after long-term cryopreservation of large-scale organs provided in this application, through specific embodiments and application scenarios.
[0054] like Figure 3As shown in the embodiment of this application, a rapid and uniform rewarming microwave heating method for long-term cryopreservation of large-scale organs is provided. This method may include the following steps 301 and 302: Step 301: Obtain the preset heating temperature curve and reference frequency.
[0055] Step 302: Based on the preset heating temperature curve and real-time feedback data, dynamically adjust the output parameters of the microwave signal generator and the microwave power amplifier until the temperature of the heated object reaches the set temperature.
[0056] The real-time feedback data includes: the forward microwave power and reflected microwave signal fed back by the spectrum analyzer, and the internal temperature and surface temperature of the heated object fed back by the temperature detection device; the output parameters include: output power, and / or, output frequency.
[0057] Specifically, prior to step 302 above, the rapid and uniform rewarming microwave heating method for long-term cryopreservation of large-scale organs provided in this application embodiment may further include the following steps 303 and 304: Step 303: In the preparation stage, the network analyzer is used to send a signal and measure the reflected signal of the resonant cavity.
[0058] Step 304: Calculate the resonant frequency based on the reflected signal, and use the resonant frequency as the reference frequency during the heating process.
[0059] For example, the rapid and uniform rewarming microwave heating method for long-term cryopreservation of large-scale organs provided in this application embodiment has the following specific process: 1. Preparations before reheating: Use a network analyzer to send a signal and measure the reflected signal data to obtain the resonant frequency as the reference frequency for starting heating.
[0060] 2. Safety Check and Equipment Connection: Check that the resonant cavity door or cover can be reliably closed to prevent microwave leakage. Connect the output of the microwave signal generator to the input of the microwave power amplifier. Connect the input of the coupler to the output of the microwave amplifier. Connect the output of the coupler to the microwave input port of the resonant cavity, and connect the coupling and reflection ends of the coupler to the spectrum analyzer.
[0061] 3. System no-load test: Without placing a sample or a reference object that does not absorb microwaves, run the system at low power for a short time to confirm that the system is operating normally and that there are no abnormal noises or temperature rises.
[0062] 4. Organ placement: Open the resonant cavity, place the cryopreserved organ inside the resonant cavity and load the temperature sensor, then quickly close the resonant cavity.
[0063] 5. Organ rewarming procedure: Turn on the signal generator and slowly adjust the microwave power of the power amplifier (relative to the reference frequency) to the set value. Monitor the microwave matching within the cavity in real time using a spectrum analyzer. If the reflected power is too high, adjust the input power frequency. The microwave frequency required for rewarming will gradually decrease over time.
[0064] 6. Temperature and Reflection Signal Detection: Continuously record microwave power (forward microwave power and reflected microwave power). Simultaneously record data from the fiber optic thermometer and infrared thermometer, and plot the temperature curve over time (adjust the heating power by comparing it with the heating curve). During the heating process, the frequency will gradually decrease.
[0065] 7. End of temperature measurement: When the temperature detected by the thermometer reaches the set temperature, the rewarming process ends. Turn off the signal generator and power amplifier, quickly open the resonant cavity and record the organ surface temperature with an infrared thermometer.
[0066] The microwave heating method provided in this application for rapid and uniform rewarming of large-scale organs after long-term cryopreservation involves, firstly, acquiring a preset heating temperature curve and a reference frequency; then, based on the preset heating temperature curve and real-time feedback data, dynamically adjusting the output parameters of the microwave signal generator and the microwave power amplifier until the temperature of the heated object reaches the set temperature; wherein, the real-time feedback data includes: forward microwave power and reflected microwave signal fed back by a spectrum analyzer, and internal and surface temperatures of the heated object fed back by a temperature detection device; the output parameters include: output power, and / or, output frequency. Thus, by using microwave heating, the temperature inside and outside the organ is made uniform during the rewarming process, which not only shortens the rewarming time but also reduces damage to the organ during the rewarming process.
[0067] It should be noted that the rapid and uniform rewarming microwave heating method for long-term cryopreservation of large-scale organs provided in this application embodiment can be executed by a control unit of a rapid and uniform rewarming microwave heating system for long-term cryopreservation of large-scale organs. This application embodiment uses the control unit executing the rapid and uniform rewarming microwave heating method for long-term cryopreservation of large-scale organs as an example to illustrate the electronic equipment provided in this application embodiment.
[0068] It should be noted that, in the embodiments of this application, the methods shown in the accompanying drawings for rapid and uniform rewarming microwave heating after long-term cryopreservation of large-scale organs are all illustrated by way of example with reference to one of the accompanying drawings in the embodiments of this application. In specific implementation, the methods shown in the accompanying drawings for rapid and uniform rewarming microwave heating after long-term cryopreservation of large-scale organs can also be implemented in conjunction with any other accompanying drawings shown in the above embodiments, which will not be elaborated here.
[0069] Figure 4 An example is a schematic diagram of the physical structure of an electronic device, such as... Figure 4 As shown, the electronic device may include: a processor 410, a communication interface 420, a memory 430, and a communication bus 440, wherein the processor 410, the communication interface 420, and the memory 430 communicate with each other through the communication bus 440. The processor 410 can call logic instructions in the memory 430 to execute a rapid and uniform rewarming microwave heating method for long-term cryopreservation of large-scale organs. This method includes: first, acquiring a preset heating temperature curve and a reference frequency; then, based on the preset heating temperature curve and real-time feedback data, dynamically adjusting the output parameters of the microwave signal generator and the microwave power amplifier until the temperature of the heated object reaches the set temperature; wherein the real-time feedback data includes: the forward microwave power and reflected microwave signal fed back by a spectrum analyzer, and the internal temperature and surface temperature of the heated object fed back by a temperature detection device; the output parameters include: output power, and / or, output frequency. In this way, by using microwave heating, the temperature inside and outside the organ is made uniform during the rewarming process, which not only shortens the rewarming time of the organ, but also reduces the damage to the organ during the rewarming process.
[0070] Furthermore, the logical instructions in the aforementioned memory 430 can be implemented as software functional units and, when sold or used as independent products, can be stored in a computer-readable storage medium. Based on this understanding, the technical solution of this application, in essence, or the part that contributes to the prior art, or a part of the technical solution, can be embodied in the form of a software product. This computer software product is stored in a storage medium and includes several instructions to cause a computer device (which may be a personal computer, server, or network device, etc.) to execute all or part of the steps of the methods described in the various embodiments of this application. The aforementioned storage medium includes various media capable of storing program code, such as USB flash drives, portable hard drives, read-only memory (ROM), random access memory (RAM), magnetic disks, or optical disks.
[0071] On the other hand, this application also provides a computer program product, which includes a computer program stored on a computer-readable storage medium. The computer program includes program instructions, which, when executed by a computer, enable the computer to execute the microwave heating method provided by the above methods for rapid and uniform rewarming of large-scale organs after long-term cryopreservation. This method includes: first, acquiring a preset heating temperature curve and a reference frequency; then, based on the preset heating temperature curve and real-time feedback data, dynamically adjusting the output parameters of the microwave signal generator and the microwave power amplifier until the temperature of the heated object reaches the set temperature; wherein the real-time feedback data includes: forward microwave power and reflected microwave signal fed back by a spectrum analyzer, and the internal and surface temperatures of the heated object fed back by a temperature detection device; the output parameters include: output power, and / or, output frequency. Thus, by using microwave heating, the temperature inside and outside the organ is made uniform during the rewarming process, which not only shortens the rewarming time but also reduces damage to the organ during the rewarming process.
[0072] Furthermore, this application also provides a computer-readable storage medium storing a computer program that, when executed by a processor, performs the aforementioned microwave heating methods for rapid and uniform rewarming after long-term cryopreservation of large-scale organs. The method includes: first, acquiring a preset heating temperature curve and a reference frequency; then, based on the preset heating temperature curve and real-time feedback data, dynamically adjusting the output parameters of the microwave signal generator and the microwave power amplifier until the temperature of the heated object reaches the set temperature; wherein the real-time feedback data includes: forward microwave power and reflected microwave signal fed back by a spectrum analyzer, and the internal and surface temperatures of the heated object fed back by a temperature detection device; the output parameters include: output power, and / or, output frequency. Thus, by using microwave heating, the temperature inside and outside the organ is made uniform during the rewarming process, which not only shortens the rewarming time but also reduces damage to the organ during the rewarming process.
[0073] The device embodiments described above are merely illustrative. The units described as separate components may or may not be physically separate. The components shown as units may or may not be physical units; that is, they may be located in one place or distributed across multiple network units. Some or all of the modules can be selected to achieve the purpose of this embodiment according to actual needs. Those skilled in the art can understand and implement this without any creative effort.
[0074] Through the above description of the embodiments, those skilled in the art can clearly understand that each embodiment can be implemented by means of software plus necessary general-purpose hardware platforms, and of course, it can also be implemented by hardware. Based on this understanding, the above technical solutions, in essence or the part that contributes to the prior art, can be embodied in the form of a software product. This computer software product can be stored in a computer-readable storage medium, such as ROM / RAM, magnetic disk, optical disk, etc., and includes several instructions to cause a computer device (which may be a personal computer, server, or network device, etc.) to execute the methods described in the various embodiments or some parts of the embodiments.
[0075] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this application.
Claims
1. A microwave heating system for rapid and uniform rewarming after long-term cryopreservation of large-scale organs, characterized in that, include: Microwave signal generator, microwave power amplifier, coupler, resonant cavity, spectrum analyzer, and temperature detection device; The microwave signal generator and microwave power amplifier are used to generate microwave energy of the required frequency and power, and input the microwave energy into the resonant cavity through the coupler to heat the object to be heated in the resonant cavity; The spectrum analyzer is used to monitor the forward microwave power of the coupler and the reflected microwave signal in the resonant cavity, and to send the monitored forward microwave power and reflected microwave signal to the control unit. The temperature detection device is used to monitor the internal temperature and surface temperature of the heated object, and send the internal temperature and surface temperature of the heated object to the control unit; The control unit is used to dynamically adjust the output parameters of the microwave signal generator and the microwave power amplifier based on a preset heating temperature curve and real-time feedback data, until the temperature of the heated object reaches the set temperature. The real-time feedback data includes: the forward microwave power and reflected microwave signal fed back by the spectrum analyzer, and the internal temperature and surface temperature of the heated object fed back by the temperature detection device; the output parameters include: output power, and / or, output frequency.
2. The system according to claim 1, characterized in that, The output terminal of the microwave power amplifier is connected to the input terminal of the coupler; the output terminal of the coupler is connected to the input terminal of the resonant cavity; the spectrum analyzer is connected to the coupling terminal and the reflection terminal of the coupler respectively.
3. The system according to claim 2, characterized in that, The spectrum analyzer is specifically used to monitor the forward microwave power of the coupler through the coupling end and to monitor the reflected microwave signal in the resonant cavity through the reflecting end; wherein the reflected microwave signal includes at least one of the following: the frequency purity of the reflected microwave, the harmonic components of the reflected microwave, and the spurious components of the reflected microwave.
4. The system according to claim 1, characterized in that, The resonant cavity includes a waveguide port, an observation window, a disassembly interface, and a heating cavity; the resonant cavity is used to realize multiple reflections and superpositions of the microwave field to improve the uniformity of the microwave field in the heating region.
5. The system according to claim 1, characterized in that, The temperature detection device includes: a fiber optic thermometer and an infrared thermometer; the fiber optic thermometer is used to measure the internal temperature of the heated object; the infrared thermometer is used to measure the surface temperature of the heated object.
6. The system according to claim 1, characterized in that, The system further includes: a network analyzer; the network analyzer is used to connect to the resonant cavity in calibration mode and calibrate the resonant cavity; wherein, calibrating the resonant cavity includes: performing impedance matching on the resonant cavity and tuning the resonant cavity.
7. The system according to claim 6, characterized in that, The network analyzer is specifically used to measure and diagnose the input impedance, reflection coefficient, and transmission characteristics of the resonant cavity, and to calibrate the resonant cavity based on these parameters.
8. The system according to claim 6 or 7, characterized in that, The control unit is specifically used, during the preparation phase, to send a signal using the network analyzer and measure the reflected signal of the resonant cavity; The control unit is further configured to calculate the resonant frequency based on the reflected signal and use the resonant frequency as a reference frequency during the heating process.
9. A rapid and uniform microwave heating method for the long-term cryopreservation of large-scale organs, characterized in that, Applied to any one of the claims 1 to 8 for rapid and uniform rewarming microwave heating system after long-term cryopreservation of large-scale organs; The method includes: Obtain the preset heating temperature curve and reference frequency; Based on the preset heating temperature curve and real-time feedback data, the output parameters of the microwave signal generator and the microwave power amplifier are dynamically adjusted until the temperature of the heated object reaches the set temperature. The real-time feedback data includes: the forward microwave power and reflected microwave signal fed back by the spectrum analyzer, and the internal temperature and surface temperature of the heated object fed back by the temperature detection device; the output parameters include: output power, and / or, output frequency.
10. The method according to claim 9, characterized in that, The method further includes dynamically adjusting the output parameters of the microwave signal generator and the microwave power amplifier based on the preset heating temperature curve and real-time feedback data until the temperature of the heated object reaches the set temperature. During the preparation phase, the network analyzer is used to send a signal and measure the reflected signal of the resonant cavity; The resonant frequency is calculated based on the reflected signal and used as the reference frequency during the heating process.