Tissue pressure measurement and fitting formula acquisition device and method

Abstract

In the tissue pressure measuring and fitting formula obtaining device and method, the light emitting module emits light signals in a time-sharing mode, the light signals comprise the emitting signal W1 and the emitting signal W2, the light receiving module receives the light signals, transmitted or reflected by tissue, of the two kinds of signals, the received light signals comprise the receiving signal Q1 and the receiving signal Q2, and the receiving signal Q1 and the receiving signal Q2 are connected in a time-sharing mode. The absorption characteristic of the tissue to light is (Q2-Q1) / (W2-W1); fitting the light absorption characteristic of the tissue with the tissue pressure to obtain a fitting formula; in different atmospheric pressure intervals, different environment temperature intervals and different chip temperature intervals, the light absorption characteristic of the tissue and the tissue pressure are fitted. The measurement accuracy in different atmospheric pressure intervals is ensured, and the measurement device does not need to be adjusted in different pressure regions.

Description

Technical Field

[0001] This application belongs to the field of biomedical technology, and in particular relates to a device and method for measuring tissue pressure and obtaining fitting formulas. Background Technology

[0002] Pressure within the human body is closely related to health. Blood pressure is the pressure of the blood itself, which is familiar to everyone. In addition, there are other body pressures such as pulmonary pressure, intracranial pressure, renal pressure, and intraocular pressure.

[0003] Intraocular pressure (IOP) is the pressure exerted by the eye's tissues on the eyeball wall. Normal IOP is between 10 and 21 mmHg; both excessively high and low IOP can affect eye function. For example, prolonged writing, watching television, or using a computer can cause eye fatigue and blurred vision. Closing the eyes briefly usually restores normal accommodation. However, if IOP increases irreversibly, glaucoma can occur, causing eye pain and swelling. Without timely treatment, it can lead to blindness.

[0004] Intraocular pressure can be measured using external devices. Traditional tonometers use mechanical equipment to contact the eyeball for measurement, or they use air to blow into the eyeball and observe the deformation of the eyeball for measurement, which is very inconvenient for the test subject.

[0005] Patent application CN115054200A, entitled "Non-contact Continuous Dynamic Intraocular Pressure Monitoring System," discloses a dynamic intraocular pressure monitoring system based on optical characteristics, which involves complex signal processing based on ocular pulse wave signals. However, it does not consider the influence of atmospheric pressure changes on intraocular pressure measurement.

[0006] Application number “2023100553102” entitled “Tissue Pressure and Tissue Moisture Content Measurement Device” discloses a device for measuring tissue pressure by means of signal absorption characteristics. This device can measure tissue pressure by means of the absorption characteristics of light signals in tissue.

[0007] In medicine, tissue pressure is generally measured relative to atmospheric pressure, such as blood pressure and intraocular pressure. When atmospheric pressure changes, the human body needs to make adaptive adjustments, and the absolute value of tissue pressure is constantly changing. Tissue pressure at different altitudes is also a relative value. When measuring tissue pressure using the absorption characteristics of light signals in tissues, the differences in environmental pressure must be taken into account.

[0008] Even in the same location, such as at low altitudes, the daily atmospheric pressure fluctuates between 0.75 and 3 mmHg. This can lead to significant measurement deviations in tissue pressure. For example, normal intraocular pressure in humans is 10 to 21 mmHg, with a normal daily fluctuation range of 8 mmHg. At low altitudes, atmospheric pressure fluctuations may be as high as 3 mmHg. Atmospheric pressure fluctuations account for more than 30% of the fluctuation range in intraocular pressure. Therefore, the influence of atmospheric pressure on tissue pressure measurement must be considered. Summary of the Invention

[0009] The technical problem this invention aims to solve is how to eliminate measurement deviations caused by changes in atmospheric pressure. To address this issue, this invention uses a pressure module to obtain atmospheric pressure values. Within different atmospheric pressure ranges, the light absorption characteristics of tissues are fitted to tissue pressure, ensuring measurement accuracy across different pressure ranges without requiring separate calibration of the measuring device in different pressure regions.

[0010] The technical solution of this application to solve the above-mentioned technical problems is a fitting formula acquisition device, including: a control module, a light emitting module, and a light receiving module; the control module is electrically connected to the light emitting module; the control module is electrically connected to the light receiving module; the light emitting module emits light signals in a time-division manner, namely, emitted signal W1 and emitted signal W2; the light receiving module receives the light signals transmitted or reflected by the tissue, and the intensity of the received light signals are received signal Q1 and received signal Q2, respectively; the light absorption characteristics of the tissue are (Q2-Q1) / (W2-W1); the light absorption characteristics of the tissue are fitted with tissue pressure to obtain a fitting formula; Includes one or more of the following technical features: Feature TA1: Also includes a pressure module, with the control module electrically connected to the pressure module; the pressure module is used to obtain atmospheric pressure values ​​and to fit the tissue's light absorption characteristics with tissue pressure in different atmospheric pressure ranges; Feature TA2: Also includes an ambient temperature sensing module, with the control module electrically connected to the ambient temperature sensing module; to fit the tissue's light absorption characteristics with tissue pressure in different ambient temperature ranges; Feature TA3: Also includes a chip temperature sensing module, with the control module electrically connected to the chip temperature sensing module; to fit the tissue's light absorption characteristics with tissue pressure in different chip temperature ranges.

[0011] The aforementioned tissue pressure measuring device includes any one or more of the following technical features: Feature TC1: The aforementioned tissue pressure is measured by a standard tissue pressure measuring device; Feature TC2: The aforementioned tissue pressure is a range value, and a fitting formula is obtained by spatially fitting the light absorption characteristics of multiple tissues with the aforementioned range value.

[0012] The technical solution of this application to solve the above-mentioned technical problems can also be a tissue pressure measuring device, including: a control module, a light emitting module, and a light receiving module; the control module is electrically connected to the light emitting module; the control module is electrically connected to the light receiving module; the light emitting module emits a light signal, and the light receiving module receives the light signal transmitted or reflected by the tissue; the tissue pressure is obtained according to the light absorption characteristics; including any one or more of the following technical features: Feature TB1: further includes a pressure module, the control module is electrically connected to the pressure module; the pressure module is used to obtain an atmospheric pressure value, and the tissue pressure is the difference relative to the atmospheric pressure value; Feature TB2: further includes an ambient temperature sensing module, the control module is electrically connected to the ambient temperature sensing module. The module includes electrical signal connections; an ambient temperature sensing module is used to measure ambient temperature; feature TB3: also includes a chip temperature sensing module, with the control module electrically connected to the chip temperature sensing module; the chip temperature sensing module is used to measure the temperature of the light emitting module or light receiving module; feature TB4: also includes an acceleration sensing module, with the control module electrically connected to the acceleration sensing module; the acceleration sensing module is used to measure the attitude of the tissue pressure measuring device; feature TB5: also includes a voice module, with the control module electrically connected to the voice module; the voice module is used to play measurement control voice; feature TB6: also includes an ambient light sensing module, with the control module electrically connected to the ambient light sensing module; the ambient light sensing module is used to measure ambient light intensity.

[0013] The aforementioned light emitting module emits light signals in a time-division manner, namely, emitted signal W1 and emitted signal W2. The aforementioned light receiving module receives the light signals transmitted or reflected by the tissue, namely, received signal Q1 and received signal Q2. The tissue's light absorption characteristics are (Q2-Q1) / (W2-W1). The tissue pressure is calculated according to the fitting formula.

[0014] The aforementioned received signal Q1 is the received signal during the period of transmitted signal W1, and the received signal strength is the sum of the received signals at N times; the aforementioned received signal Q2 is the received signal during the period of transmitted signal W2, and the received signal strength is the sum of the received signals at N times.

[0015] The aforementioned tissue pressure measuring device includes any one or more of the following technical features: Feature TC1: The tissue pressure is intraocular pressure; Feature TC2: The tissue pressure is intracranial pressure; Feature TC3: The tissue pressure is muscle tissue pressure; Feature TC4: The aforementioned light receiving module is a camera module, which captures a measurement image of the measurement site; the aforementioned received signal Q1 or received signal Q2 is the sum of the pixel values ​​of the measurement image, or the aforementioned received signal Q1 or received signal Q2 is the sum of the R, G, or B components of the pixels of the measurement image; Feature TC5: The aforementioned light emitting module includes light emitting components of two or more wavelengths; the aforementioned receiving component receives the light intensity signals of the different wavelengths of light transmitted or reflected by the tissue.

[0016] The technical solution of this application to solve the above-mentioned technical problem can also be a method for obtaining a fitting formula. During the time period of the emitted light signal W1, a received light signal Q1 is detected, where the received light signal is the light signal transmitted or reflected by the emitted light signal through tissue; during the time period of the emitted light signal W2, a received light signal Q2 is detected, where the received light signal is the light signal transmitted or reflected by the emitted light signal through tissue; the tissue's light absorption characteristics are (Q2-Q1) / (W2-W1); the tissue's light absorption characteristics are fitted with tissue pressure to obtain a fitting formula; or the above absorption characteristics and tissue pressure are used to train an AI model to obtain a tissue pressure AI calculation model; including any one or more of the following technical features:

[0017] Feature TD1: Atmospheric pressure values ​​are measured in different atmospheric pressure ranges to obtain fitting formulas corresponding to different atmospheric pressure ranges; Feature TD2: Tissue light absorption characteristics are fitted with tissue pressure in different ambient temperature ranges to obtain fitting formulas corresponding to different ambient temperatures; Feature TD3: Tissue light absorption characteristics are fitted with tissue pressure in different chip temperature ranges to obtain fitting formulas corresponding to different chip temperatures; Feature TD4: The above tissue pressure is measured by a standard tissue pressure measuring device; Feature TD5: The above tissue pressure is a range value, and a fitting formula is obtained by fitting multiple sets of tissue light absorption characteristics to the above range value space.

[0018] The technical solution of this application to solve the above-mentioned technical problem can also be a tissue pressure measurement method, wherein during the time period of emitted light signal W1, received light signal Q1 is detected, and the received light signal is the light signal transmitted or reflected by the emitted light signal through the tissue; during the time period of emitted light signal W2, received light signal Q2 is detected, and the received light signal is the light signal transmitted or reflected by the emitted light signal through the tissue; the absorption characteristics of the tissue to light are (Q2-Q1) / (W2-W1); the tissue pressure is calculated according to the fitting formula; or the tissue pressure is obtained according to the tissue pressure AI calculation model; including any one or more of the following technical features: Feature TE1: Obtain the atmospheric pressure value, and select the corresponding atmospheric pressure range according to the atmospheric pressure value. Fitting formula; Feature TE2: Obtain the ambient temperature and select the fitting formula corresponding to the ambient temperature range; Feature TE3: Obtain the temperature of the light emitting device and / or light receiving device and select the fitting formula corresponding to the temperature range based on the temperature of the above devices; Feature TE4: Determine whether the position of the tissue pressure measuring device is correctly aligned with the tester's left or right eye by detecting the acceleration sensor signal; Feature TE5: When testing the pressure of the left and right eyes, combine the acceleration sensor signal and play voice prompts to guide the tester to correctly place the tissue pressure measuring device; Feature TE6: When testing intraocular pressure, determine whether the user has correctly placed the tissue pressure measuring device by detecting the ambient light intensity signal.

[0019] The above-mentioned tissue pressure measurement method includes any one or more of the following technical features: Feature TF1: The received signal Q1 is the received signal during the transmission signal W1, and the received signal strength is the sum of the received signals at N time points; The received signal Q2 is the received signal during the transmission signal W2, and the received signal strength is the sum of the received signals at N time points; Feature TF2: The tissue pressure is the intraocular pressure; Feature TF3: The tissue pressure is the intracranial pressure; Feature TF4: The tissue pressure is the muscle tissue pressure; Feature TF5: A measurement image is obtained by photographing the measurement site, and the received signal Q1 or received signal Q2 is the sum of the pixel values ​​of the measurement image, or the received signal Q1 or received signal Q2 is the sum of the R, G, or B components of the pixel points of the measurement image; Feature TF6: The transmitted light signal includes two or more light signals of different wavelengths.

[0020] The emitted light signal intensities W1 and W2 are equal to the set values; the tissue pressure = A×LOG(Q2-Q1)+B, or tissue pressure = A×LN(Q2-Q1)+B, where A and B are fitting parameters; including any one or more of the following technical features: Feature TG1: Tissue pressure relative to atmospheric pressure = tissue pressure - P, where P is the atmospheric pressure at the time of measurement; Feature TG2: The atmospheric pressure at the time of measurement is P, and fitting is performed or different fitting parameters A or B are selected based on the range of atmospheric pressure P values; Feature TG3: The ambient temperature at the time of measurement is T, and fitting is performed or different fitting parameters A or B are selected based on the range of ambient temperature T values.

[0021] One of the technical effects of the above-mentioned technical solution is that changes in environmental pressure lead to changes in the solubility of gases in biological tissues. According to the Lambert-Beer law, the light absorption characteristics will change accordingly. By fitting the formula under different pressure conditions, tissue pressure can be accurately measured.

[0022] One of the technical effects of the above-mentioned technical solution is that changes in ambient temperature lead to changes in the solubility of gases in biological tissues. According to the Lambert-Beer law, the light absorption characteristics will change accordingly. By fitting the formula under different ambient temperature conditions, tissue pressure can be accurately measured.

[0023] One of the technical effects of the above-mentioned technical solution is that by using a pressure module to obtain atmospheric pressure values, the tissue's light absorption characteristics and tissue pressure are fitted in different atmospheric pressure ranges, ensuring measurement accuracy in different atmospheric pressure ranges without the need to adjust the measuring device separately in different pressure regions.

[0024] One of the technical effects of the above-mentioned technical solution is that it can fit the tissue's light absorption characteristics with tissue pressure in different ambient temperature ranges, thereby reducing the influence of ambient temperature on the measurement.

[0025] One of the technical effects of the above-mentioned technical solution is that it can fit the light absorption characteristics of tissue to tissue pressure in different chip temperature ranges, thereby reducing the impact of chip temperature changes on the measurement.

[0026] One of the technical effects of the above-mentioned technical solution is that the acceleration sensing module is used to measure the posture of the tissue pressure measuring device, reminding the test subject to adjust the posture and reduce the influence of posture on the measurement.

[0027] One of the technical effects of the above-mentioned technical solution is that the voice module is used to play measurement control voice, making the test more user-friendly, especially for people with visual impairments.

[0028] One of the technical effects of the above-mentioned technical solution is that the ambient light sensing module is used to measure the ambient light intensity, thereby reducing the impact of ambient light intensity on the measurement.

[0029] One of the technical effects of the above-mentioned technical solution is that by transmitting two different intensity signals at different times, the influence of different ambient light on the measurement can be effectively shielded.

[0030] One of the technical effects of the above-mentioned technical solution is that by emitting optical signals of two or more wavelengths, different wavelengths of optical signals correspond to different material absorption characteristics, which can be used to check the changes in absorbance of different gases or substances due to different pressures, thereby improving the accuracy of the measurement.

[0031] One of the technical effects of the above-mentioned technical solution is that the received signal strength is the sum of the received signals at N times, which improves the signal-to-noise ratio and significantly improves the measurement accuracy.

[0032] One of the technical advantages of the above-mentioned technical solution is that it has a wide range of applicability for measuring tissue pressure, including intraocular pressure, intracranial pressure, and muscle tissue pressure.

[0033] One of the technical effects of the above-mentioned technical solution is that the light receiving module is a camera module, which is easy to acquire, can perform light sensing over a large area, and improves the signal-to-noise ratio.

[0034] One of the technical effects of the above-mentioned technical solution is that the optical receiving module is a camera module, and by measuring different RGB signal components, measurement signals can be obtained in the sensitive light band. Attached Figure Description

[0035] Figure 1 This is one of the functional block diagrams of an organization pressure measuring device;

[0036] Figure 2 This is one of the tables illustrating the parameters obtained from the fitting formula;

[0037] Figure 3 This is the second table illustrating the parameters obtained from the fitting formula;

[0038] Figure 4 This is the second functional block diagram of a tissue pressure measuring device;

[0039] Figure 5 This is the third functional block diagram of a tissue pressure measuring device;

[0040] Figure 6 This is the fourth functional block diagram of a tissue pressure measuring device;

[0041] Figure 7 This is the fifth functional block diagram of a tissue pressure measuring device;

[0042] Figure 8 This is the sixth functional block diagram of a tissue pressure measuring device;

[0043] Figure 9This is a schematic diagram of time-division multiplexing and receiving signals of two different strengths.

[0044] Specific implementation

[0045] Way

[0046] The contents of this application will be further described in detail below with reference to the accompanying drawings.

[0047] It should be noted that the following description is of preferred embodiments of the present invention and does not constitute any limitation on the present invention. The description of the preferred embodiments of the present invention is merely an explanation of the general principles of the present invention. The embodiments described in this application are only some embodiments of the present invention, and not all embodiments. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0048] In the description of this application, it should be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," and "counterclockwise," etc., indicating orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, are only for the convenience of describing the invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the invention. Furthermore, the terms "first," "second," and technical features numbered with Arabic numerals 1, 2, 3, etc., and numbers such as "A" and "B," are used for descriptive purposes only, for ease of explanation, and do not represent a temporal or spatial order; they should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Therefore, features defined with "first," "second," and numbered with Arabic numerals 1, 2, 3, etc., may explicitly or implicitly include one or more of that feature. In the description of the invention, "a number" means two or more, unless otherwise explicitly specified.

[0049] like Figure 1 In one embodiment of a fitting formula acquisition device and method, the device includes: a control module, a light emitting module, and a light receiving module; the control module is electrically connected to the light emitting module; the control module is electrically connected to the light receiving module; the light emitting module emits light signals in a time-division manner, namely, emitted signal W1 and emitted signal W2; the light receiving module receives the light signals transmitted or reflected by the tissue, and the intensity of the received light signals is received signal Q1 and received signal Q2, respectively; the tissue's light absorption characteristics are (Q2-Q1) / (W2-W1); the tissue's light absorption characteristics are fitted with tissue pressure to obtain a fitting formula.

[0050] like Figure 1 In one embodiment of a fitting formula acquisition device and method, a pressure module is further included, and the control module is electrically connected to the pressure module. The pressure module is used to obtain atmospheric pressure values ​​and to fit the tissue's light absorption characteristics with tissue pressure in different atmospheric pressure ranges. Atmospheric pressure values ​​are measured in different atmospheric pressure ranges to obtain the corresponding fitting formulas for those ranges.

[0051] like Figure 2 The parameters obtained from the fitting formula are the fitting parameters for each pressure range.

[0052] like Figure 4 In one embodiment of a fitting formula acquisition device and method, an ambient temperature sensing module is included, and a control module is electrically connected to the ambient temperature sensing module. The device performs fitting of tissue light absorption characteristics with tissue pressure in different ambient temperature ranges. The ambient temperature is obtained, and a fitting formula corresponding to that ambient temperature range is selected. The fitting of tissue light absorption characteristics with tissue pressure is performed in different ambient temperature ranges to obtain fitting formulas corresponding to different ambient temperatures.

[0053] like Figure 3 The parameters obtained from the fitting formula correspond to the fitting parameters for each pressure range and each ambient temperature range.

[0054] For different altitude regions, corresponding to multiple different temperature ranges, fitting is performed. During measurement, the corresponding pressure range is first selected based on the pressure value, and then the fitting parameters are found based on the obtained temperature range.

[0055] During the fitting process, tissue pressure is measured using a standard tissue pressure measuring device. For example, before testing intraocular pressure, the light absorption characteristics are measured using a fitting formula, and then intraocular pressure is measured using a traditional tonometer. Multiple measurements are obtained by measuring different populations to complete the fitting process. Because traditional tonometers can irritate the intraocular pressure, it is generally recommended to first use a fitting formula to measure the light absorption characteristics, and then measure the intraocular pressure.

[0056] The aforementioned tissue pressures are range values. By fitting the light absorption characteristics of multiple tissues to these range values, a fitting formula is obtained. The intraocular pressure range of healthy individuals is fixed, and the daily fluctuation range is determined. Furthermore, by measuring the intraocular pressure values ​​of different groups at different times of day each day, the measured values ​​can be fitted to the intraocular pressure range of that group. This method eliminates the need for control measurements using a traditional tonometer, simplifies the fitting process, and significantly reduces the workload.

[0057] Artificial intelligence is developing very rapidly and has become a general-purpose tool. By calibrating the absorption characteristics of measured light with corresponding tissue pressure data, such as intraocular pressure data, and training with artificial intelligence algorithms, an artificial intelligence calculation model of tissue pressure can be obtained.

[0058] like Figure 7 and Figure 8 In one embodiment of a fitting formula acquisition device and method, a chip temperature sensing module is further included, and the control module is electrically connected to the chip temperature sensing module. The device performs fitting of tissue light absorption characteristics with tissue pressure in different chip temperature ranges. By fitting tissue light absorption characteristics with tissue pressure in different chip temperature ranges, fitting formulas corresponding to different chip temperatures are obtained.

[0059] Optical devices emit light intensities differently across different temperature ranges, and similarly, optical receivers exhibit varying receiving characteristics at different temperatures, requiring different fitting formulas. Alternatively, the optical device can be operated within a predetermined temperature range, with its temperature obtained via a chip temperature sensor. By monitoring this temperature, the light signal intensity can be measured within the set temperature range.

[0060] like Figure 9 In one embodiment of a fitting formula acquisition device and method, during the time period of emitted light signal W1, received light signal Q1 is detected, and the received light signal is the light signal transmitted or reflected by the emitted light signal through the tissue; during the time period of emitted light signal W2, received light signal Q2 is detected, and the received light signal is the light signal transmitted or reflected by the emitted light signal through the tissue; the tissue's light absorption characteristics are (Q2-Q1) / (W2-W1); the tissue's light absorption characteristics are fitted with tissue pressure to obtain a fitting formula; or the above absorption characteristics and tissue pressure are used to train an AI model to obtain a tissue pressure AI calculation model;

[0061] By measuring the received light signal Q1 multiple times during the period of transmitting the light signal W1, the signal-to-noise ratio can be improved. This type of device actually measures the changes in the chemical composition inside the tissue, and the effective signal is weak. By fixing the intensity of the transmitted light signal and measuring the received light signal multiple times, the sensitivity of the detection device can be increased many times over. High-sensitivity measurement can be achieved with low-cost devices.

[0062] like Figure 1An embodiment of a tissue pressure measuring device and method includes: a control module, a light emitting module, and a light receiving module; the control module is electrically connected to the light emitting module; the control module is electrically connected to the light receiving module; the light emitting module emits a light signal, and the light receiving module receives the light signal transmitted or reflected through the tissue; tissue pressure is obtained based on the light absorption characteristics; the device also includes a pressure module, and the control module is electrically connected to the pressure module; the pressure module is used to obtain an atmospheric pressure value, and the tissue pressure is the difference relative to the atmospheric pressure value.

[0063] like Figure 4 In one embodiment of a tissue pressure measuring device and method, an ambient temperature sensing module is further included, and the control module is electrically connected to the ambient temperature sensing module; the ambient temperature sensing module is used to measure the ambient temperature.

[0064] like Figure 7 and Figure 8 In one embodiment of a tissue pressure measurement device and method, a chip temperature sensing module is further included, and the control module is electrically connected to the chip temperature sensing module; the chip temperature sensing module is used to measure the temperature of the light emitting module or the light receiving module.

[0065] like Figure 5 , Figure 7 and Figure 8 In one embodiment of a tissue pressure measurement device and method, an acceleration sensing module is further included, and the control module is electrically connected to the acceleration sensing module. The acceleration sensing module is used to measure the posture of the tissue pressure measurement device. In intraocular pressure measurement, when a device measures the left or right eye, the intraocular pressure measurement device needs to be set up correctly. With the acceleration sensing module, the correct placement of the user's test device can be ensured.

[0066] like Figure 6 , Figure 7 and Figure 8 In one embodiment of a tissue pressure measurement device and method, a voice module is further included, and the control module is electrically connected to the voice module; the voice module is used to play measurement control voice; in measurements such as intraocular pressure, the user may have poor vision, and voice prompts can help the user use the measurement device effectively.

[0067] like Figure 8 In one embodiment of a tissue pressure measurement device and method, an ambient light sensing module is further included. The control module is electrically connected to the ambient light sensing module, which is used to measure the ambient light intensity.

[0068] like Figure 9In one embodiment of a tissue pressure measuring device and method, the light emitting module emits light signals in a time-division manner, namely, emitted signal W1 and emitted signal W2. The light receiving module receives the light signals transmitted or reflected by the tissue, namely, received signal Q1 and received signal Q2. The tissue's light absorption characteristics are (Q2-Q1) / (W2-W1). The tissue pressure is calculated according to the fitting formula.

[0069] like Figure 9 In one embodiment of a tissue pressure measuring device and method, the received signal Q1 is the received signal during the transmission signal W1, and the received signal strength is the sum of the received signals at N times; the received signal Q2 is the received signal during the transmission signal W2, and the received signal strength is the sum of the received signals at N times.

[0070] In some embodiments not shown in the accompanying drawings, the aforementioned tissue pressure is intraocular pressure; the aforementioned tissue pressure is intracranial pressure; the aforementioned tissue pressure is muscle tissue pressure.

[0071] In some embodiments not shown in the accompanying drawings, the aforementioned light receiving module is a camera module, which captures images of the measurement area to obtain measurement images; the aforementioned received signal Q1 or received signal Q2 is the sum of the pixel values ​​of the aforementioned measurement image, or the aforementioned received signal Q1 or received signal Q2 is the sum of the R, G, or B components of the aforementioned measurement image pixels.

[0072] In some embodiments not shown in the accompanying drawings, the light emitting module includes light emitting components of two or more wavelengths; the receiving component receives light intensity signals of the different wavelengths of light transmitted or reflected by tissue.

[0073] like Figure 1 In one embodiment of a tissue pressure measurement method, during the time period of emitted light signal W1, received light signal Q1 is detected, and the received light signal is the light signal transmitted or reflected by the emitted light signal through the tissue; during the time period of emitted light signal W2, received light signal Q2 is detected, and the received light signal is the light signal transmitted or reflected by the emitted light signal through the tissue; the tissue's light absorption characteristics are (Q2-Q1) / (W2-W1); the tissue pressure is calculated according to a fitting formula; or the tissue pressure is obtained according to a tissue pressure AI calculation model; the atmospheric pressure value is obtained, and a fitting formula corresponding to the atmospheric pressure range is selected based on the atmospheric pressure value.

[0074] like Figure 7 and Figure 8 In one embodiment of a tissue pressure measurement method, the temperatures of a light emitting device and / or a light receiving device are obtained, and a fitting formula corresponding to the temperature range is selected based on the device temperatures.

[0075] like Figure 5 , Figure 7 and Figure 8 In one embodiment of a tissue pressure measurement method, the position of the tissue pressure measuring device is determined to be correctly aligned with the test subject's left or right eye by detecting an acceleration sensor signal.

[0076] like Figure 6 , Figure 7 and Figure 8 In one embodiment of a tissue pressure measurement method, when testing the pressure of the left and right eyes, the test subject is prompted to correctly position the tissue pressure measurement device by playing a voice prompt, in conjunction with the acceleration sensor signal.

[0077] like Figure 8 In one embodiment of a tissue pressure measurement device and method, when testing intraocular pressure, the user determines whether the tissue pressure measurement device is correctly positioned by detecting the ambient light intensity signal.

[0078] In some embodiments not shown in the accompanying drawings, the intensity of the emitted light signal W1 and W2 are equal to a set value; the tissue pressure is A×LOG(Q2-Q1)+B, or the tissue pressure is A×LN(Q2-Q1)+B, where A and B are parameters obtained by fitting.

[0079] In some embodiments not shown in the accompanying drawings, the tissue pressure relative to atmospheric pressure = tissue pressure - P, where P is the atmospheric pressure at the time of measurement;

[0080] In some embodiments not shown in the accompanying drawings, the atmospheric pressure during the above measurement is P, and fitting is performed or different fitting parameters A or B are selected based on the range of atmospheric pressure P values. For example... Figure 2 The parameters obtained from the fitting formula are the fitting parameters for each pressure range.

[0081] In some embodiments not shown in the accompanying drawings, the ambient temperature during the above measurement is T, and fitting is performed or different fitting parameters A or B are selected based on the range of ambient temperature T values. For example... Figure 3 The parameters obtained from the fitting formula correspond to the fitting parameters for each pressure range and each ambient temperature range.

[0082] While the present invention has been described and illustrated with reference to preferred embodiments and several alternatives, the invention is not limited to the specific descriptions herein. Other alternatives or equivalent components may also be used to practice the invention.

Claims

1. A device for obtaining a fitting formula, Its features are, Includes: a control module, an optical transmitting module, and an optical receiving module; The control module and the optical emission module are electrically connected; The control module and the optical receiver module are electrically connected; The light emitting module emits light signals in a time-division manner, namely, emitted signal W1 and emitted signal W2. The light receiving module receives the light signals transmitted or reflected by the tissue, and the intensity of the received light signals are received signal Q1 and received signal Q2, respectively. The light absorption characteristics of the tissue are (Q2-Q1) / (W2-W1). The light absorption characteristics of the tissue are fitted with the tissue pressure to obtain the fitting formula. Includes one or more of the following technical features: Feature TA1: It also includes a pressure module, and the control module is electrically connected to the pressure module; the pressure module is used to obtain atmospheric pressure values ​​and to fit the tissue's light absorption characteristics with tissue pressure in different atmospheric pressure ranges; Feature TA2: It also includes an ambient temperature sensing module, and the control module is electrically connected to the ambient temperature sensing module; it fits the tissue's light absorption characteristics with tissue pressure in different ambient temperature ranges. Feature TA3: It also includes a chip temperature sensing module, and the control module is electrically connected to the chip temperature sensing module; it fits the tissue's light absorption characteristics with tissue pressure in different chip temperature ranges.

2. The tissue pressure measuring device according to claim 1, characterized in that, Includes one or more of the following technical features: Feature TC1: The tissue pressure is obtained by measuring with a standard tissue pressure measuring device; Feature TC2: The tissue pressure is a range value. A fitting formula is obtained by fitting the light absorption characteristics of multiple tissues to the range value space.

3. A tissue pressure measuring device, Its features are, Includes: a control module, an optical transmitting module, and an optical receiving module; The control module is electrically connected to the optical transmitting module; the control module is electrically connected to the optical receiving module. The light emitting module emits light signals, and the light receiving module receives the light signals that have been transmitted or reflected through the tissue; based on the light absorption characteristics, the tissue pressure is obtained. Includes one or more of the following technical features: Feature TB1: It also includes a pneumatic module, and the control module is electrically connected to the pneumatic module; the pneumatic module is used to obtain atmospheric pressure value, and the tissue pressure is the difference relative to the atmospheric pressure value; Feature TB2: It also includes an ambient temperature sensing module, and the control module is electrically connected to the ambient temperature sensing module; the ambient temperature sensing module is used to measure the ambient temperature. Feature TB3: It also includes a chip temperature sensing module, and the control module is electrically connected to the chip temperature sensing module; the chip temperature sensing module is used to measure the temperature of the light emitting module or the light receiving module. Feature TB4: It also includes an acceleration sensing module, and the control module is electrically connected to the acceleration sensing module; the acceleration sensing module is used to measure the attitude of the tissue pressure measuring device; Feature TB5: It also includes a voice module, and the control module is electrically connected to the voice module; the voice module is used to play measurement control voice. Feature TB6: It also includes an ambient light sensing module. The control module is electrically connected to the ambient light sensing module, which is used to measure the ambient light intensity.

4. The tissue pressure measuring device according to claim 3, characterized in that, The light emitting module emits light signals in a time-division manner, namely, emitted signal W1 and emitted signal W2. The light receiving module receives the light signals transmitted or reflected by the tissue, namely, received signal Q1 and received signal Q2. The tissue's light absorption characteristics are (Q2-Q1) / (W2-W1). Tissue pressure was calculated using the fitted formula.

5. The tissue pressure measuring device according to claim 3 or 4, characterized in that, The received signal Q1 is the received signal during the period of the transmitted signal W1, and the strength of the received signal is the sum of the received signals at N times; The received signal Q2 is the received signal during the transmission of signal W2, and the received signal strength is the sum of the received signals at N time points.

6. The tissue pressure measuring device according to any one of claims 3 or 4, characterized in that, Includes one or more of the following technical features: Feature TC1: The tissue pressure is the intraocular pressure; Feature TC2: The tissue pressure is intracranial pressure; Feature TC3: The tissue pressure is muscle tissue pressure; Feature TC4: The light receiving module is a camera module, which captures the measurement area to obtain a measurement image; the received signal Q1 or received signal Q2 is the sum of the pixel values ​​of the measurement image, or the received signal Q1 or received signal Q2 is the sum of the R, G or B components of the pixel of the measurement image; Feature TC5: The light emitting module includes light emitting components of two or more wavelengths; the receiving component receives the light intensity signals of the different wavelengths of light after transmission or reflection through tissue.

7. A method for obtaining a fitting formula, characterized in that, During the period of transmitting light signal W1, receiving light signal Q1 is detected. The received light signal is the light signal that has been transmitted or reflected by the tissue after the transmitted light signal. During the period of transmitting light signal W2, receiving light signal Q2 was detected. The received light signal is the light signal that has been transmitted or reflected by the tissue after the transmitted light signal. The light absorption characteristics of the tissue are (Q2-Q1) / (W2-W1); The light absorption characteristics of tissue are fitted with tissue pressure to obtain a fitting formula; or the absorption characteristics and tissue pressure are used to train an AI model to obtain a tissue pressure AI calculation model. Includes one or more of the following technical features: Feature TD1: Atmospheric pressure values ​​are measured in different atmospheric pressure ranges, and fitting formulas corresponding to different atmospheric pressure ranges are obtained; Feature TD2: Fitting the light absorption characteristics of tissues to tissue pressure in different ambient temperature ranges to obtain fitting formulas corresponding to different ambient temperatures; Feature TD3: Fitting the light absorption characteristics of tissue to tissue pressure in different chip temperature ranges to obtain fitting formulas corresponding to different chip temperatures; Feature TD4: The tissue pressure is obtained by measuring with a standard tissue pressure measuring device; Feature TD5: The tissue pressure is a range value. A fitting formula is obtained by fitting the light absorption characteristics of multiple tissues to the range value space.

8. A method for measuring tissue pressure, characterized in that, During the period of transmitting light signal W1, receiving light signal Q1 is detected. The received light signal is the light signal that has been transmitted or reflected by the tissue after the transmitted light signal. During the period of transmitting light signal W2, receiving light signal Q2 was detected. The received light signal is the light signal that has been transmitted or reflected by the tissue after the transmitted light signal. The light absorption characteristics of the tissue are (Q2-Q1) / (W2-W1); Tissue pressure can be calculated using a fitted formula; or tissue pressure can be obtained using a tissue pressure AI calculation model. Includes one or more of the following technical features: Feature TE1: Obtain the atmospheric pressure value and select the fitting formula corresponding to the atmospheric pressure range based on the atmospheric pressure value; Feature TE2: Obtain the ambient temperature and select the fitting formula corresponding to the ambient temperature range based on the ambient temperature. Feature TE3: Obtain the temperature of the optical emitting device and / or optical receiving device, and select a fitting formula corresponding to the temperature range based on the device temperature; Feature TE4: By detecting the acceleration sensor signal, it determines whether the position of the tissue pressure measuring device is correctly aligned with the test subject's left or right eye; Feature TE5: When testing left and right eye pressure, it combines the accelerometer signal and plays a voice prompt to guide the test subject to correctly position the tissue pressure measuring device. Feature TE6: When testing intraocular pressure, it determines whether the user has correctly positioned the tissue pressure measuring device by detecting the ambient light intensity signal.

9. The tissue pressure measurement method according to claim 7 or 8, characterized in that, Includes one or more of the following technical features: feature TF1: The received signal Q1 is the received signal during the transmission signal W1 period, and the received signal strength is the sum of the received signals at N time points; the received signal Q2 is the received signal during the transmission signal W2 period, and the received signal strength is the sum of the received signals at N time points. Feature TF2: The tissue pressure is the intraocular pressure; Feature TF3: The tissue pressure is intracranial pressure; Feature TF4: The tissue pressure is muscle tissue pressure; Feature TF5: A measurement image is obtained by capturing the measurement area, wherein the received signal Q1 or received signal Q2 is the sum of the pixel values ​​of the measurement image, or the received signal Q1 or received signal Q2 is the sum of the R, G or B components of the pixel of the measurement image; Feature TF6: The emitted optical signal includes two or more optical signals of different wavelengths.

10. The tissue pressure measurement method according to claim 7 or 8, characterized in that, The intensity of the emitted optical signal, W1, and W2 are equal to the set values; The tissue pressure is defined as A×LOG(Q2-Q1)+B, or tissue pressure is defined as A×LN(Q2-Q1)+B, where A and B are parameters obtained through fitting. Includes one or more of the following technical features: Feature TG1: Tissue pressure relative to atmospheric pressure = tissue pressure - P, where P is the atmospheric pressure at the time of measurement; Feature TG2: The atmospheric pressure at the time of measurement is P, and different fitting parameters A or B are selected based on the range of atmospheric pressure P values. Feature TG3: The ambient temperature during the measurement is T. Based on the range of ambient temperature T values, fitting is performed or different fitting parameters A or B are selected.

Images