Enhanced sodium-calcium-silicon medicinal glass with magnesium-aluminum-silicon composite structure and preparation method of enhanced sodium-calcium-silicon medicinal glass

Abstract

The invention discloses enhanced sodium-calcium-silicon medicinal glass with a magnesium-aluminum-silicon composite structure and a preparation method of the enhanced sodium-calcium-silicon medicinal glass. The glass comprises the following components in percentage by mole: 60.0%-67.0% of Si < 4 + >; 1.0%-2.0% of Al < 3 + >; the content of the [Mg (AlO4) 4] cluster is 1.0%-2.0%; the content of the [Mg (SiO4) 4] cluster is 0.5%-1.0%; the content of the [Mg (AlO6) 6] cluster is 0.6%-1.5%; the content of Na < + > is 14.5%-19.5%; 7.0%-9.0% of Ca < 2 + >; 2.0%-4.0% of Mg < 2 + >; and anions comprise the following components in percentage by mole: 65%-75% of bridge oxygen and 25%-35% of non-bridge oxygen. The coating is prepared by adopting a high-temperature melting-annealing process, and has relatively high water resistance and chemical stability. The invention develops a magnesium-aluminum-silicon composite structure reinforced sodium-calcium-silicon medicinal glass with good water resistance.

Description

Technical Field

[0001] This invention belongs to the field of pharmaceutical glass manufacturing technology, specifically relating to a sodium-calcium-silicon pharmaceutical glass with a magnesium-aluminum-silicon composite structure and its preparation method. Background Technology

[0002] Pharmaceutical glass, as the core carrier of drug packaging, directly relates to the stability, safety, and shelf life of drugs, and is widely used in the packaging of high-end pharmaceutical products such as injectables, vaccines, and biological agents. Sodium-calcium silicate glass has become the mainstream type of pharmaceutical glass due to its readily available raw materials, excellent formability and processability, and moderate cost. However, its insufficient water resistance is a core bottleneck for its application in high-end formulations. According to GB / T6582—2021 "Test Method and Classification of Water Resistance of Glass Particles at 98℃", the water resistance of pharmaceutical glass must reach HGB1 level. If the water resistance does not meet the standard, alkali metal ions in the glass matrix can easily undergo ion exchange with the drug solution, causing changes in the pH value of the drug solution, component degradation, and even glass surface delamination and cracking, seriously threatening drug safety.

[0003] With the rapid development of the biopharmaceutical industry, high-end formulations place higher demands on the water resistance and chemical stability of pharmaceutical glass. Current methods for modifying the water resistance of sodium-calcium-silicon pharmaceutical glass primarily involve adding oxides such as MgO and Al2O3 to enhance network polymerization and improve performance. However, traditional modifications have significant limitations: simply introducing oxides can easily lead to glass phase separation, abnormal forming viscosity, and difficulty in precisely controlling the network structure. Some modification schemes attempt to construct magnesium-based coordination structures, but these suffer from problems such as unreasonable cluster design, multiple oxides coexisting in the same coordination unit, and imbalanced cation ratios, resulting in unstable cluster formation and an inability to effectively block water molecule penetration and alkali ion dissolution.

[0004] The degree of polymerization of a glass network is directly related to its water resistance. Bridged oxygen, as the core structure connecting the cations in the network, determines the network density, while non-bridged oxygen is the main site for water erosion and ion dissolution. Existing soda-lime silica glasses generally suffer from a low proportion of bridged oxygen (usually below 65%) and an excessively high content of non-bridged oxygen, resulting in large network voids that allow water molecules to easily penetrate into the matrix and trigger erosion reactions. Meanwhile, in traditional formulations, Mg... 2+ Al 3+ They exist mostly in the form of free ions, making it difficult to form a stable composite structure. This prevents them from fully utilizing their dense network and inhibiting ion dissolution, resulting in limited improvement in the water resistance of the glass and making it difficult to meet the long-term storage requirements of high-end formulations.

[0005] To address the aforementioned bottlenecks, the industry urgently needs to develop a sodium-calcium-silicon pharmaceutical glass capable of precisely controlling the network structure and stably forming composite reinforcing units. Research indicates that magnesium-based composite coordination clusters can optimize the glass structure by anchoring network nodes and filling voids. If magnesium-aluminum-silicon composite clusters can be constructed and the bridging / non-bridging oxygen ratio can be synergistically controlled, it is expected to significantly improve water resistance and chemical stability while ensuring glass forming performance. Based on this, this invention designs a sodium-calcium-silicon glass with a specific magnesium-aluminum-silicon composite cluster structure. By rationally proportioning the components and cluster units, it solves the problems of insufficient water resistance and poor structural stability in existing pharmaceutical glasses, meeting the needs of high-end pharmaceutical packaging. Summary of the Invention

[0006] The purpose of this invention is to provide a sodium-calcium-silicon pharmaceutical glass with a magnesium-aluminum-silicon composite structure that meets water resistance requirements, and a method for preparing the same.

[0007] The objective of this invention is achieved through the following technical solution: A first aspect of this invention provides a sodium-calcium-silicon pharmaceutical glass reinforced with a magnesium-aluminum-silicon composite structure, the composition and molar percentage of which are as follows:

[0008] Si 4+ 60.0%~67.0%

[0009] Al 3+ 1.0%~2.0%

[0010] [Mg(AlO4)4] clusters 1.0%~2.0%

[0011] [Mg(SiO4)4] clusters 0.5%~1.0%

[0012] [Mg(AlO6)6] clusters 0.6%~1.5%

[0013] Na + 14.5%~19.5%

[0014] Ca 2+ 7.0%~9.0%

[0015] Mg 2+ 2.0%~4.0%

[0016] K + 0.1%~1.5%

[0017] According to a molar percentage meter, the anion has the following composition:

[0018] Bridging oxygen 65%~75%

[0019] Non-bridging oxygen 25%~35%

[0020] Among them, Si4+ Al 3+ The core cations for constructing the glass network; [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] represent magnesium-centered complex coordination clusters, connecting aluminum-oxygen tetrahedra, silicon-oxygen tetrahedra, and aluminum-oxygen octahedral units respectively, to enhance the density and water resistance of the glass network; Na + Ca 2+ Mg 2+ K + For network modifiers.

[0021] A second aspect of this invention provides a method for preparing the above-mentioned magnesium-aluminum-silicon composite reinforced sodium-calcium-silicon pharmaceutical glass, the steps of which are as follows:

[0022] (1) Weigh the required mass of SiO2, Al2O3, MgO, Na2CO3, CaO, and K2CO3 powder raw materials according to the molar percentage ratio;

[0023] (2) After weighing, the powdered raw materials are mixed evenly and placed into a crucible. Then, the crucible is placed in a box furnace at 1520~1560℃ for heating and melting and clarifying for 3~4 hours. After the melt is clarified and uniform, it is poured into a preheated mold to form a glass block. Then, the glass block is transferred to a box furnace at 530~560℃ for annealing for 3~4 hours to remove internal stress. Finally, it is cooled to room temperature with the furnace to obtain the sodium calcium silicon pharmaceutical glass with magnesium aluminum silicon composite structure.

[0024] The beneficial results of this invention are as follows: (1) This invention significantly improves the water resistance of glass by constructing a magnesium-aluminum-silicon composite cluster reinforcement network. The [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters anchor aluminum-oxygen tetrahedrons, silicon-oxygen tetrahedrons, and aluminum-oxygen octahedrons, respectively, and synergistically regulate the bridging oxygen ratio to 65%~75%, effectively densifying the glass network, reducing non-bridging oxygen erosion sites, stably meeting the water resistance requirements, blocking water molecule penetration and alkali ion dissolution, avoiding adverse reactions between the drug solution and the glass matrix, and ensuring drug safety. (2) The composition ratio of this invention is scientific and reasonable, taking into account both structural stability and molding processability. 4 + Al 3+ Construct the core network skeleton, Na + Ca 2+ K + Precise control of melt viscosity and molding properties, free Mg 2+The auxiliary strengthening network, the synergistic effect of each component and the magnesium-aluminum-silicon structural cluster, avoids defects such as glass phase separation and cracking, while maintaining the advantages of readily available and cost-controllable raw materials for sodium-calcium-silicon glass, which is superior to the traditional single oxide modification scheme. (3) The preparation process of the present invention is simple and controllable, and is suitable for large-scale production. The conventional melting-annealing process is adopted, and the melting and annealing temperature and holding time parameters are adapted to the reaction characteristics of the raw materials, which can ensure the stable formation of magnesium-aluminum-silicon structural clusters and eliminate internal stress. The resulting glass block has a uniform structure and stable performance. It can be converted into pharmaceutical glass containers without complicated equipment, which is suitable for the packaging needs of high-end preparations such as injections and vaccines, and has good prospects for industrial application. Attached Figure Description

[0025] Fig. 1 This is the XRD pattern of the glass obtained in Example 1;

[0026] Fig. 2 This is the FTIR spectrum of the glass obtained in Example 1;

[0027] Fig. 3 This is the transmission spectrum of the glass obtained in Example 1; Detailed Implementation

[0028] The present invention will now be described in detail with reference to the accompanying drawings. Unless otherwise specified, the features of the following embodiments and implementations can be combined with each other.

[0029] This invention proposes a sodium-calcium-silicon pharmaceutical glass with a magnesium-aluminum-silicon composite structure, which has the following composition by molar percentage:

[0030] Si 4+ 60.0%~67.0%

[0031] Al 3+ 1.0%~2.0%

[0032] [Mg(AlO4)4] clusters 1.0%~2.0%

[0033] [Mg(SiO4)4] clusters 0.5%~1.0%

[0034] [Mg(AlO6)6] clusters 0.6%~1.5%

[0035] Na + 14.5%~19.5%

[0036] Ca 2+ 7.0%~9.0%

[0037] Mg 2+ 2.0%~4.0%

[0038] K+ 0.1%~1.5%

[0039] According to a molar percentage meter, the anion has the following composition:

[0040] Bridging oxygen 65%~75%

[0041] Non-bridging oxygen 25%~35%

[0042] Among them, Si 4+ Al 3+ The core cations for constructing the glass network; [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] represent magnesium-centered complex coordination clusters, connecting aluminum-oxygen tetrahedra, silicon-oxygen tetrahedra, and aluminum-oxygen octahedral units, respectively; Na + Ca 2+ Mg 2+ K + For network modifiers.

[0043] The sodium-calcium-silicon pharmaceutical glass with a magnesium-aluminum-silicon composite structure provided by this invention is prepared according to the following steps:

[0044] (1) Weigh the required mass of SiO2, Al2O3, MgO, Na2CO3, CaO, and K2CO3 powder raw materials according to the molar percentage ratio;

[0045] (2) After weighing, mix the powdered raw materials evenly and put them into a crucible. Then place it in a box furnace at 1520~1560℃ for heating and melting and clarifying for 3~4 hours. After the melt is clarified and uniform, pour it into a preheated mold to form a glass block. Then transfer the glass block to a box furnace at 530~560℃ for annealing for 3~4 hours to remove internal stress.

[0046] Example 1:

[0047] To form the aforementioned [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters, weigh the required masses of SiO2, Al2O3, MgO, Na2CO3, CaO, and K2CO3 powder raw materials respectively; mix the powder raw materials evenly and place them in an alumina crucible. In this composition, the [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters account for 1.5%, 0.8%, and 1% of the total molar amount of the glass component, respectively, with free Al... 3+ Na + Ca 2+ Mg 2+ K +Each component accounts for 1.5%, 16.5%, 8%, 3%, and 1% of the total molar amount of the glass components. The glass is then placed in a box furnace at 1550ºC for 3 hours for heat preservation and melting. The glass is then poured into a mold to form a glass block. The glass block is placed at 550℃ for 4 hours to remove internal stress. A portion of the glass is then taken out, crushed, and ground into powder for use in the remaining tests.

[0048] The density of the magnesium-aluminum-silicon composite sodium-calcium-silicon glass obtained in this embodiment is 2.55 g / cm³. 2 .like Figs. 1-3 As shown, after measurement, the XRD pattern of this glass exhibits diffuse peaks, indicating an amorphous state. In the FTIR spectrum, at 450 cm⁻¹... −1 740cm −1 1000 cm −1 1120 cm −1 1540 cm −1 and 1630 cm −1 Vibrations corresponding to the XO (X = Na / Mg / K / Ca) bond, bending vibration of the Al-O bond, stretching vibration of the Si-O-Si bond, stretching vibration of the Si-O-Si bond, asymmetric stretching vibration of the carbonate group, and stretching vibration of the -OH group were observed at various locations. The transmission spectrum indicates that the resulting glass exhibits a transmittance exceeding 80% in the visible light range. According to GB / T6582—2021 "Test Method and Classification of Water Resistance of Glass Particles at 98 °C", this embodiment achieves HGB1 water resistance, making it suitable for packaging applications requiring stringent water resistance, such as those for injectables and high-end pharmaceuticals.

[0049] Example 2:

[0050] To form the aforementioned [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters, weigh the required masses of SiO2, Al2O3, MgO, Na2CO3, CaO, and K2CO3 powder raw materials respectively; mix the powder raw materials evenly and place them in an alumina crucible. In this composition, the [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters account for 1%, 0.5%, and 0.6% of the total molar amount of the glass component, respectively, with free Al... 3+ Na + Ca 2+ Mg 2+ K +The components, comprising 1%, 14.5%, 7%, 2%, and 0.1% of the total molar amount of the glass composition, were then placed in a box furnace at 1550ºC for 3 hours of heat treatment and melted. The melt was then poured into a mold to form a glass block. The glass block was then placed at 550°C for 4 hours to remove internal stress. A portion of the block was removed, crushed, and ground into powder for further testing. According to GB / T6582—2021 "Test Method and Classification of Water Resistance of Glass Particles at 98 °C", this embodiment achieves HGB1 water resistance, suitable for packaging of injectables, high-end pharmaceuticals, and other products requiring stringent water resistance.

[0051] Example 3:

[0052] To form the aforementioned [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters, weigh the required masses of SiO2, Al2O3, MgO, Na2CO3, CaO, and K2CO3 powder raw materials respectively; mix the powder raw materials evenly and place them in an alumina crucible. In this composition, the [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters account for 2%, 1%, and 1.5% of the total molar amount of the glass component, respectively, with free Al... 3+ Na + Ca 2+ Mg 2+ K + The components, comprising 2%, 19.5%, 9%, 4%, and 1.5% of the total molar amount of the glass composition, were then placed in a box furnace at 1550ºC for 3 hours of heat treatment and melted. The melt was then poured into a mold to form a glass block. The glass block was then placed at 550°C for 4 hours to remove internal stress. A portion of the block was removed, crushed, and ground into powder for further testing. According to GB / T6582—2021 "Test Method and Classification of Water Resistance of Glass Particles at 98 °C", this embodiment achieves HGB1 water resistance, suitable for packaging of injectables, high-end pharmaceuticals, and other products requiring stringent water resistance.

[0053] Example 4:

[0054] To form the aforementioned [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters, weigh the required masses of SiO2, Al2O3, MgO, Na2CO3, CaO, and K2CO3 powder raw materials respectively; mix the powder raw materials evenly and place them in an alumina crucible. In this composition, the [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters account for 1.5%, 0.7%, and 1.2% of the total molar amount of the glass component, respectively, with free Al... 3+ Na + Ca 2+Mg 2+ K + The components, comprising 1.4%, 17%, 8%, 3%, and 1% of the total molar amount of the glass composition, were then placed in a box furnace at 1550ºC for 3 hours of heat treatment and melting. The melt was then poured into a mold to form a glass block. The glass block was then placed at 550°C for 4 hours to remove internal stress. A portion of the block was removed, crushed, and ground into powder for the remaining tests. According to GB / T6582—2021 "Test Method and Classification of Water Resistance of Glass Particles at 98 °C", this embodiment achieves HGB1 water resistance, suitable for packaging of injectables, high-end pharmaceuticals, and other products requiring stringent water resistance.

[0055] Example 5:

[0056] To form the aforementioned [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters, weigh the required masses of SiO2, Al2O3, MgO, Na2CO3, CaO, and K2CO3 powder raw materials respectively; mix the powder raw materials evenly and place them in an alumina crucible. In this composition, the [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters account for 1.2%, 0.9%, and 0.8% of the total molar amount of the glass component, respectively, with free Al... 3+ Na + Ca 2+ Mg 2+ K + The components, comprising 1.6%, 19%, 8.5%, 3.5%, and 1.2% of the total molar amount of the glass composition, were then placed in a box furnace at 1550ºC for 3 hours of heat treatment and melted. The melt was then poured into a mold to form glass blocks. These blocks were then placed at 550°C for 4 hours to remove internal stress. A portion of the blocks was removed, crushed, and ground into powder for further testing. According to GB / T6582—2021 "Test Method and Classification of Water Resistance of Glass Particles at 98 °C", this embodiment achieves HGB1 water resistance, suitable for packaging of injectables, high-end pharmaceuticals, and other products requiring stringent water resistance.

[0057] Example 6:

[0058] To form the aforementioned [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters, weigh the required masses of SiO2, Al2O3, MgO, Na2CO3, CaO, and K2CO3 powder raw materials respectively; mix the powder raw materials evenly and place them in an alumina crucible. In this composition, the [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters account for 1.8%, 0.6%, and 1.1% of the total molar amount of the glass component, respectively, with free Al...3+ Na + Ca 2+ Mg 2+ K + The components, comprising 1.2%, 15%, 7.5%, 2.5%, and 0.5% of the total molar amount of the glass composition, were then placed in a box furnace at 1550ºC for 3 hours of heat treatment and melting. The melt was then poured into a mold to form a glass block. The glass block was then placed at 550°C for 4 hours to remove internal stress. A portion of the block was removed, crushed, and ground into powder for the remaining tests. According to GB / T6582—2021 "Test Method and Classification of Water Resistance of Glass Particles at 98 °C", this embodiment achieves HGB1 water resistance, suitable for packaging of injectables, high-end pharmaceuticals, and other products requiring stringent water resistance.

[0059] Example 7:

[0060] To form the aforementioned [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters, weigh the required masses of SiO2, Al2O3, MgO, Na2CO3, CaO, and K2CO3 powder raw materials respectively; mix the powder raw materials evenly and place them in an alumina crucible. In this composition, the [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters account for 1.1%, 0.75%, and 0.7% of the total molar amount of the glass component, respectively, with free Al... 3+ Na + Ca 2+ Mg 2+ K + The components, comprising 1.1%, 16%, 7.2%, 2.2%, and 0.3% of the total molar amount of the glass composition, were then placed in a box furnace at 1550ºC for 3 hours of heat treatment and melted. The melt was then poured into a mold to form glass blocks. These blocks were then placed at 550°C for 4 hours to remove internal stress. A portion of the blocks was removed, crushed, and ground into powder for further testing. According to GB / T6582—2021 "Test Method and Classification of Water Resistance of Glass Particles at 98 °C", this embodiment achieves HGB1 water resistance, suitable for packaging of injectables, high-end pharmaceuticals, and other products requiring stringent water resistance.

[0061] Example 8:

[0062] To form the aforementioned [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters, weigh the required masses of SiO2, Al2O3, MgO, Na2CO3, CaO, and K2CO3 powder raw materials respectively; mix the powder raw materials evenly and place them in an alumina crucible. In this composition, the [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters account for 1.7%, 0.85%, and 1.3% of the total molar amount of the glass component, respectively, with free Al... 3+ Na + Ca 2+ Mg 2+ K + The glass components, comprising 1.8%, 18%, 8.8%, 3.8%, and 1.4% of the total molar amount, were then placed in a box furnace at 1550ºC for 3 hours of melting and holding. The melt was then poured into a mold to form glass blocks. These blocks were then held at 550°C for 4 hours to remove internal stress. A portion of the blocks was removed, crushed, and ground into powder for further testing. According to GB / T6582—2021 "Test Method and Classification of Water Resistance of Glass Particles at 98 °C", this embodiment achieves HGB1 water resistance, suitable for packaging of injectables, high-end pharmaceuticals, and other products requiring stringent water resistance.

[0063] Example 9:

[0064] To form the aforementioned [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters, weigh the required masses of SiO2, Al2O3, MgO, Na2CO3, CaO, and K2CO3 powder raw materials respectively; mix the powder raw materials evenly and place them in an alumina crucible. In this composition, the [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters account for 1.4%, 0.95%, and 0.9% of the total molar amount of the glass component, respectively, with free Al... 3+ Na + Ca 2+ Mg 2+ K + The components, comprising 1.5%, 17.5%, 8.2%, 2.8%, and 0.8% of the total molar amount of the glass composition, were then placed in a box furnace at 1550ºC for 3 hours of heat treatment and melted. The melt was then poured into a mold to form glass blocks. These blocks were then placed at 550°C for 4 hours to remove internal stress. A portion of the blocks was removed, crushed, and ground into powder for further testing. According to GB / T6582—2021 "Test Method and Classification of Water Resistance of Glass Particles at 98 °C", this embodiment achieves HGB1 water resistance, suitable for packaging of injectables, high-end pharmaceuticals, and other products requiring stringent water resistance.

[0065] Example 10:

[0066] To form the aforementioned [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters, weigh the required masses of SiO2, Al2O3, MgO, Na2CO3, CaO, and K2CO3 powder raw materials respectively; mix the powder raw materials evenly and place them in an alumina crucible. In this composition, the [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] clusters account for 1.9%, 0.8%, and 1.4% of the total molar amount of the glass component, respectively, with free Al... 3+ Na + Ca 2+ Mg 2+ K + The components, comprising 1.9%, 15.5%, 7.8%, 3.2%, and 0.6% of the total molar amount of the glass composition, were then placed in a box furnace at 1550ºC for 3 hours of heat treatment and melting. The melt was then poured into a mold to form a glass block. The glass block was then placed at 550°C for 4 hours to remove internal stress. A portion of the block was removed, crushed, and ground into powder for further testing. According to GB / T6582—2021 "Test Method and Classification of Water Resistance of Glass Particles at 98 °C", this embodiment achieves HGB1 water resistance, suitable for packaging of injectables, high-end pharmaceuticals, and other products requiring stringent water resistance.

Claims

1. A sodium-calcium-silicon pharmaceutical glass with a magnesium-aluminum-silicon composite structure, characterized in that, Mole percentage meter has the following components: And 4+ 60.0%~67.0% Al 3+ 1.0%~2.0% [Mg(AlO4)4] clusters 1.0%~2.0% [Mg(SiO4)4] clusters 0.5%~1.0% [Mg(AlO6)6] clusters 0.6%~1.5% That + 14.5%~19.5% That 2+ 7.0%~9.0% Mg 2+ 2.0%~4.0% K + 0.1%~1.5% According to a molar percentage meter, the anion has the following composition: Bridging oxygen 65%~75% Non-bridging oxygen 25%~35% Among them, Si 4+ Al 3+ The core cations for constructing the glass network; [Mg(AlO4)4], [Mg(SiO4)4], and [Mg(AlO6)6] represent magnesium-centered complex coordination clusters, connecting aluminum-oxygen tetrahedra, silicon-oxygen tetrahedra, and aluminum-oxygen octahedral units respectively, to enhance the density and water resistance of the glass network; Na + Ca 2+ Mg 2+ K + For network modifiers.

2. A method for preparing the pharmaceutical glass container of claim 1, characterized in that, Includes the following steps: (1) Weigh the required mass of SiO2, Al2O3, MgO, Na2CO3, CaO, and K2CO3 powder raw materials according to the molar percentage ratio; (2) After weighing, the powdered raw materials are mixed evenly and placed into a crucible. Then, the crucible is placed in a box furnace at 1520~1560℃ for heating and melting and clarifying for 3~4 hours. After the melt is clarified and uniform, it is poured into a preheated mold to form a glass block. Then, the glass block is transferred to a box furnace at 530~560℃ for annealing for 3~4 hours to remove internal stress. Finally, it is cooled to room temperature with the furnace to obtain the sodium calcium silicon pharmaceutical glass with magnesium aluminum silicon composite structure.

3. The sodium-calcium-silicon pharmaceutical glass with a magnesium-aluminum-silicon composite structure as described in claim 1, characterized in that, According to GB / T6582—2021 "Test Method and Classification of Water Resistance of Glass Particles at 98 °C", its water resistance reaches HGB1 level.

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