Botulinum-like peptide detection equipment for cosmetic production

Abstract

The invention discloses botulinum-like peptide detection equipment for cosmetic production, and belongs to the technical field of botulinum-like peptide detection.The clamping and shaking-up assembly comprises a plurality of rotating sleeves capable of synchronously rotating, and a plurality of attaching guide wheels used for clamping centrifugal tubes are arranged in the rotating sleeves; a bearing groove seat capable of moving in the vertical direction is arranged below the rotating sleeve and is used for upwards supporting the bottom of the centrifugal tube. According to the invention, in the shaking stage, the compound motion of revolution, rotation and periodic vertical vibration of the rotating sleeve is utilized to ensure that a to-be-detected sample and a buffer solution are rapidly and fully mixed, so that the mixing uniformity and the reaction effect are remarkably improved, and the accuracy of sample data detection is improved; after the component is switched to a detection mode, a sample can be automatically positioned and stood by the driving motor, and then accurate component analysis is sequentially completed by the botulinum-like component detection mechanism, so that personal errors and cross contamination risks are reduced.

Description

Technical Field

[0001] This invention belongs to the field of botulinum toxin-like peptide detection technology, and particularly relates to a botulinum toxin-like peptide detection device for cosmetic production. Background Technology

[0002] With the rapid development of the cosmetics industry, peptides with botulinum toxin-like effects (botox peptides) are widely used as key active ingredients for anti-wrinkle and skin-firming purposes, and their market demand continues to grow. However, botulinum toxin-like peptides are bioactive ingredients, and their effective components and concentrations must be precisely controlled, so they need to be tested before leaving the factory.

[0003] According to Chinese Patent Publication No. CN208537425U, a device for detecting peptide concentration is disclosed, including a detection chamber and a first test tube rack and a second test tube rack arranged at the front and rear ends of the detection chamber. The detection chamber has a detection unit and a colorimetric unit. The detection unit is arranged laterally at the front end of the detection chamber and is a biuret reagent tube, which is composed of reagent A and reagent B, where reagent A is a sodium hydroxide solution and reagent B is a copper sulfate solution. The colorimetric unit is arranged laterally at the rear end of the detection chamber and is a colorimetric tube with at least two colorimetric segments, namely a first colorimetric segment and a second colorimetric segment, which are respectively arranged at the upper end and the lower end of the colorimetric tube. The biuret reagent tube and the colorimetric tube are respectively mounted on the first test tube rack and the second test tube rack, and fixing clips are provided on both sides of the two test tube racks.

[0004] However, the above scheme has the following drawbacks due to the lack of mixing and shaking of the sample and the supporting solution: it makes it difficult to mix the sample (such as cosmetic stock solution) and the supporting buffer solution quickly and thoroughly, thus affecting the efficiency and accuracy of the detection. Therefore, it needs to be improved. Summary of the Invention

[0005] The purpose of this invention is to solve the problem that it is difficult to quickly and thoroughly mix the sample and the matching buffer solution, thereby affecting the efficiency and accuracy of the detection, and to propose a botulinum toxin-like peptide detection device for cosmetic production.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: A botulinum toxin-like peptide detection device for cosmetic production includes a rotating column, and a clamping and shaking component and multiple connecting frames that can move synchronously are provided on the outer periphery of the rotating column; The clamping and shaking assembly includes multiple rotating sleeves that can rotate synchronously. Each rotating sleeve is provided with multiple guide wheels for clamping the centrifuge tubes. Below the rotating sleeves is a support groove that can move in the vertical direction and is used to support the bottom of the centrifuge tubes upwards.

[0007] As a further description of the above technical solution: The connecting frame consists of an upper horizontal part, a lower horizontal part and a vertical part. Multiple rotating sleeves are arranged in a circumferential array on the outside of the rotating column. The rotating sleeves are rotatably connected to the upper horizontal part. The supporting groove is slidably connected to the upper horizontal part. A flexible pad is provided inside the supporting groove. The rotating column is provided with a base at its bottom, and a constant temperature tank is provided at the center of the top of the base. The rotating column is rotatably connected to the constant temperature tank. The top of the rotating sleeve is connected to a limit ring, and the outer surface of the rotating sleeve is provided with a threaded groove.

[0008] As a further description of the above technical solution: The clamping and shaking assembly further includes: Multiple drive gears are arranged in a circular array on the outer periphery of the rotating column, and the drive gears are connected to the outer surface of the rotating sleeve; A fixed gear ring is connected to the constant temperature bath, and multiple drive gears are meshed with the fixed gear ring.

[0009] As a further description of the above technical solution: The clamping and shaking assembly further includes: Multiple sets of movable rods, each set consisting of two movable rods, the two movable rods in the same set are symmetrically connected to the bottom of the support groove, and the bottom of the two movable rods in the same set is connected to the same trigger wheel, the movable rods are slidably connected to the lower horizontal part; Multiple sets of second springs, each set of second springs consists of two second springs, the second springs are sleeved on the outer surface of the moving rod, and the two ends of the second springs are respectively connected to the trigger wheel and the lower horizontal part; The bottom ring is connected to the bottom of the inner wall of the constant temperature bath. The top of the bottom ring is connected to a plurality of trigger blocks arranged in a circular array. The cross-sectional shape of the trigger blocks is trapezoidal. The trigger blocks can drive the trigger wheel to move upward when the trigger wheel rotates.

[0010] As a further description of the above technical solution: The clamping and shaking assembly further includes: Multiple rotating rings are fitted around the outside of the rotating sleeve, and the rotating rings can move vertically in the rotating sleeve; Multiple sets of push blocks, each set of push blocks consists of multiple push blocks, and the multiple push blocks in the same set are connected in a circular array at the bottom of the rotating ring; Multiple sets of push wheels, each set consisting of multiple push wheels, are arranged in a circumferential array outside the rotating sleeve. One side of each push wheel is attached to one side of the push block. A sliding rod is connected to one side of the push block. One end of the sliding rod extends into the interior of the rotating sleeve and is connected to the side of the attached guide wheel. A first spring is sleeved on the outer surface of the sliding rod. The two ends of the first spring are respectively connected to one side of the rotating sleeve and one side of the push wheel.

[0011] As a further description of the above technical solution: The clamping and shaking assembly further includes: Multiple threaded rings are threadedly connected to a rotating sleeve, and the rotating ring is rotatably connected to the bottom of the threaded rings; Multiple fixed rings are connected to the outer surface of the rotating sleeve, and the fixed rings are located below the threaded ring. Multiple fixed slide rods arranged in a circumferential array are connected to the top of the fixed rings, and the pushing block is slidably connected to the fixed slide rods.

[0012] As a further description of the above technical solution: The rotating column has a cavity inside, and a shape-changing component is provided on the outer periphery of the rotating column. The shape-changing component includes: Multiple adjusting screws are arranged in a circular array outside the rotating column, and the adjusting screws are rotatably connected to the rotating column. Multiple lead screw seats are arranged in a circular array outside the rotating column. One side of each lead screw seat is connected to one side of the connecting frame, and the lead screw seat is connected to the adjusting lead screw drive. Multiple transmission gears are arranged in a circular array within the cavity, and each transmission gear is connected to one end of an adjusting screw.

[0013] As a further description of the above technical solution: The mode switching component also includes: An adjusting gear disc is rotatably connected to the cavity, and the adjusting gear disc is meshed with a transmission gear. A rotating rod is connected to the top of the adjusting gear plate, and the other end of the rotating rod extends to the outside of the cavity and is connected to a knob.

[0014] As a further description of the above technical solution: The mode switching component also includes: Multiple sets of telescopic rods, each set consisting of two telescopic rods, with both ends of the telescopic rods connected to a rotating column and a connecting frame, and the two telescopic rods in the same set symmetrically arranged on both sides of the adjusting screw.

[0015] As a further description of the above technical solution: Also includes: A protective outer shell is attached to the top of the base, and two symmetrically distributed closed doors are provided on one side of the protective outer shell; The botulinum toxin-like peptide component detection mechanism is located on one side of the top of the base and consists of a lifting mechanism and a detection probe.

[0016] Compared with existing technologies, a botulinum toxin-like peptide detection device for cosmetic production that adopts the above technical solution has the following beneficial effects: 1. In this invention, by setting up a clamping and shaking assembly, multiple centrifuge tubes can be conveniently and stably installed during the installation stage through a rotatable and switchable rotating sleeve and a rapid axial clamping mechanism. During the shaking stage, the combined motion of the rotating sleeve's revolution, rotation, and periodic vertical vibration ensures rapid and thorough mixing of the sample and buffer solution, significantly improving mixing uniformity and reaction effect, and enhancing the accuracy of sample data. Simultaneously, after the assembly switches to detection mode, the drive motor can automatically position and settle the sample, which is then sequentially analyzed by a botulinum toxin-like peptide component detection mechanism, improving the overall automation process and reducing the risk of human error and cross-contamination.

[0017] 2. In this invention, the centrifuge tube can be flexibly switched between conventional installation, static, testing modes and oscillation mode through the linkage of the knob, rotating rod, adjusting gear, transmission gear and adjusting screw: Under normal conditions, the connecting frame is far away from the fixed gear ring, which facilitates the stable installation, placement and position change of the centrifuge tube; when oscillation is required, simply turn the knob to drive the screw seat to move the connecting frame and driving gear closer to the fixed gear ring, so that the driving gear meshes with the fixed gear ring and the trigger wheel and trigger block are aligned, thereby automatically switching to the oscillation state, improving the adaptability and working efficiency of the centrifuge tube in different usage scenarios. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the overall three-dimensional structure of the present invention; Figure 2 This is a schematic diagram of the internal three-dimensional structure of the present invention; Figure 3 This is a partial three-dimensional cross-sectional view of the present invention; Figure 4 This is a three-dimensional structural diagram of the clamping and shaking component in this invention; Figure 5 This is a partial three-dimensional disassembled structural diagram of the clamping and shaking component in this invention; Figure 6 For the present invention Figure 5 Enlarged structural diagram of section A; Figure 7 This is a partial three-dimensional structural diagram of the clamping and shaking component in this invention; Figure 8 This is a three-dimensional cross-sectional view of the form switching component in this invention; Figure 9 For the present invention Figure 8 Enlarged structural diagram of section B.

[0019] Legend: 1. Protective shell; 2. Base; 3. Thermostatic bath; 4. Clamping and shaking assembly; 401. Rotating sleeve; 402. Threaded ring; 403. Fixed gear ring; 404. Bottom ring; 405. Trigger block; 406. Supporting groove; 407. Rotating ring; 408. Adhesive guide wheel; 409. Push block; 410. Push wheel; 411. Fixed slide rod; 412. Fixed ring; 413. First spring; 414. Sliding rod; 415. Trigger wheel; 416. Second spring; 417. Moving rod; 418. Drive gear; 5. Botulinum toxin-like peptide component detection mechanism; 6. Connecting frame; 7. Form switching assembly; 701. Knob; 702. Adjusting gear plate; 703. Transmission gear; 704. Telescopic rod; 705. Adjusting screw; 706. Screw seat; 8. Rotating column. Detailed Implementation

[0020] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0021] Please see Figures 1-9 The present invention provides a technical solution: A botulinum toxin-like peptide detection device for cosmetic production includes a rotating column 8, with a base 2 at its bottom. A drive motor is housed inside the base 2, with one end of the motor's output shaft extending into a constant temperature bath 3 and connecting to the bottom of the rotating column 8. The constant temperature bath 3 is located at the center of the top of the base 2, and the rotating column 8 is rotatably connected to the constant temperature bath 3. A clamping and shaking assembly 4 and multiple synchronously movable connecting frames 6 are arranged on the outer periphery of the rotating column 8. The device also includes: A protective outer shell 1 is connected to the top of the base 2, and two symmetrically distributed closed doors are provided on one side of the protective outer shell 1; The botulinum toxin-like peptide component detection mechanism 5 is located on one side of the top of the base 2 and consists of a lifting mechanism and a detection probe. The botulinum toxin-like peptide component detection mechanism 5 is a liquid chromatography-mass spectrometry instrument, which is existing technology and will not be described in detail here. The clamping and shaking assembly 4 includes multiple rotating sleeves 401 that can rotate synchronously. A limit ring is connected to the top of the rotating sleeve 401. A threaded groove is opened on the outer surface of the rotating sleeve 401. Multiple fitting guide wheels 408 for clamping the centrifuge tube are provided inside the rotating sleeve 401. A support groove seat 406 that can move in the vertical direction is provided below the rotating sleeve 401. The support groove seat 406 is used to support the bottom of the centrifuge tube upward. The connecting frame 6 is composed of an upper horizontal part, a lower horizontal part and a vertical part. Multiple rotating sleeves 401 are distributed in a circumferential array on the outside of the rotating column 8. The rotating sleeves 401 are rotatably connected to the upper horizontal part. The support groove seat 406 is slidably connected to the upper horizontal part. A flexible pad is provided inside the support groove seat 406. The clamping and shaking assembly 4 further includes: Multiple drive gears 418 are arranged in a circular array on the outer periphery of the rotating column 8. The drive gears 418 are connected to the outer surface of the rotating sleeve 401 and are located below the upper horizontal part. A fixed gear ring 403 is connected to the constant temperature bath 3, and multiple drive gears 418 are meshed with the fixed gear ring 403. Multiple sets of movable rods 417, each set of movable rods 417 consists of two movable rods 417, the two movable rods 417 in the same set are symmetrically connected to the bottom of the support groove seat 406, and the bottom of the two movable rods 417 in the same set is connected to the same trigger wheel 415, and the movable rods 417 are slidably connected to the lower horizontal part. Multiple sets of second springs 416, each set of second springs 416 consists of two second springs 416, the second springs 416 are sleeved on the outer surface of the moving rod 417, and the two ends of the second springs 416 are respectively connected to the trigger wheel 415 and the lower horizontal part; The bottom ring 404 is connected to the bottom of the inner wall of the constant temperature bath 3. The top of the bottom ring 404 is connected to a plurality of trigger blocks 405 arranged in a circular array. The cross-sectional shape of the trigger blocks 405 is trapezoidal. The trigger blocks 405 can drive the trigger wheel 415 to move upward when the trigger wheel 415 rotates. Multiple rotating rings 407 are sleeved on the outside of the rotating sleeve 401, and the rotating rings 407 can move in the vertical direction of the rotating sleeve 401; Multiple sets of push blocks 409, each set of push blocks 409 consists of multiple push blocks 409, and the multiple push blocks 409 in the same set are connected in a circular array at the bottom of the rotating ring 407; Multiple sets of push wheels 410, each set of push wheels 410 is composed of multiple push wheels 410, and the multiple push wheels 410 in the same set are distributed in a circumferential array outside the rotating sleeve 401. One side of the push wheel 410 is attached to one side of the push block 409. A sliding rod 414 is connected to one side of the push block 409. One end of the sliding rod 414 extends into the interior of the rotating sleeve 401 and is connected to one side of the attached guide wheel 408. A first spring 413 is sleeved on the outer surface of the sliding rod 414. The two ends of the first spring 413 are respectively connected to one side of the rotating sleeve 401 and one side of the push wheel 410. Multiple threaded rings 402 are threadedly connected to a rotating sleeve 401, and the rotating ring 407 is rotatably connected to the bottom of the threaded rings 402; Multiple fixing rings 412 are connected to the outer surface of the rotating sleeve 401, and the fixing rings 412 are located below the threaded ring 402. Multiple fixing slide rods 411 arranged in a circumferential array are connected to the top of the fixing rings 412. The pushing block 409 is slidably connected to the fixing slide rods 411.

[0022] The specific usage method and working principle are as follows: Take the sample to be tested (such as cosmetic stock solution) and the matching buffer solution into the centrifuge tube. Then, the staff opens the closed door. At this time, the morphology switching component 7 controls the connecting frame 6 to move away from the fixed toothed ring 403 and the trigger block 405, so that multiple rotating sleeves 401 are in the centrifuge tube installation mode. At this point, the operator places the centrifuge tubes into the rotating sleeve 401, ensuring the bottom of the centrifuge tubes is in contact with the flexible pad inside the support groove 406. Then, the operator screws on the threaded ring 402. The threaded ring 402 engages with the threads on the outside of the rotating sleeve 401, causing the threaded ring 402 to screw downwards. The threaded ring 402 drives the rotating ring 407 downwards, which in turn drives multiple pushing blocks 409 to move downwards simultaneously. The pushing blocks 409 drive the pushing wheels 410 to move along the axis of the rotating sleeve 401. The multiple pushing wheels 410 are driven by the sliding rod 414. Multiple fitting guide wheels 408 move synchronously in the axial direction, so that the fitting guide wheels 408 complete the axial positioning and clamping of the centrifuge tube. However, due to the rotation characteristics of the fitting guide wheels 408 themselves, the axial movement of the centrifuge tube can be guaranteed to be undisturbed. After the installation of a centrifuge tube is completed, the drive motor drives the rotating column 8 to rotate 60 degrees, so that the adjacent rotating sleeve 401 rotates 60 degrees under the drive of the connecting frame 6, so that the adjacent empty rotating sleeve 401 rotates to the position facing the operator. The operator repeats the above operation until all the rotating sleeves 401 are installed. After the centrifuge tube is installed, the mode switching component 7 is activated and drives multiple rotating sleeves 401 to move synchronously toward the fixed gear ring 403 through the connecting frame 6, so that the drive gear 418 meshes with the fixed gear ring 403. At this time, the trigger wheel 415 is located between two adjacent trigger blocks 405, so that the centrifuge tube is in the shaking mode. Afterwards, the sealing door is closed, the drive motor starts and drives the rotating column 8 to rotate. The rotating column 8 drives multiple rotating sleeves 401 to revolve around the axis of the rotating column 8 through the connecting frame 6. At the same time, the drive gear 418 rotates under the drive of the fixed gear ring 403, and the drive gear 418 drives the rotating sleeves 401 to rotate around their own axis. The rotating sleeves 401 drive the centrifuge tube to rotate axially through the contact guide wheel 408, realizing the mixing of the sample to be tested and the matching buffer solution inside. At the same time, the connecting frame 6 drives the support slot 406 to rotate around the axis of the bottom ring 404, supporting the centrifuge tube. The tray 406 drives the trigger wheel 415 to rotate around the axis of the bottom ring 404 via two moving rods 417. The trigger wheel 415 periodically contacts the trigger block 405. The trigger wheel 415 moves upward under the drive of the trigger block 405, and the tray 406 drives the centrifuge tube to move upward. When the trigger wheel 415 separates from the trigger block 405, the trigger wheel 415 moves downward under the action of the second spring 416. At this time, the centrifuge tube moves downward under its own gravity, thereby forming a vertical shaking and mixing of the sample to be tested and the matching buffer solution in the centrifuge tube. After the sample to be tested and the matching buffer solution in the centrifuge tube are shaken evenly, the morphology switching component 7 drives the rotating sleeve 401 away from the fixed toothed ring 403 and the trigger block 405 through the connecting frame 6. After the centrifuge tube is left to stand for about 2 minutes, the botulinum toxin-like component detection mechanism 5 performs component detection on the sample in the centrifuge tube located directly below. It mainly identifies the molecular characteristics, immunological properties or physicochemical properties of botulinum toxin-like peptides. After the detection is completed and the data is recorded, the drive motor rotates 60 degrees, so that the adjacent centrifuge tube rotates to below the botulinum toxin-like component detection mechanism 5. The above operation is repeated to complete all the detections.

[0023] Please see Figures 8-9 The rotating column 8 has a cavity inside, and a shape switching component 7 is provided on the outer periphery of the rotating column 8. The shape switching component 7 includes: Multiple adjusting screws 705 are arranged in a circular array outside the rotating column 8, and the adjusting screws 705 are rotatably connected to the rotating column 8. Multiple lead screw seats 706 are arranged in a circular array outside the rotating column 8. One side of each lead screw seat 706 is connected to one side of the connecting frame 6, and the lead screw seat 706 is connected to the adjusting lead screw 705 in a transmission connection. Multiple transmission gears 703 are arranged in a circular array within the cavity, and one end of each transmission gear 703 is connected to an adjusting screw 705. The adjusting gear 702 is rotatably connected to the cavity, and the adjusting gear 702 is meshed with the transmission gear 703. A rotating rod is connected to the top of the adjusting gear plate 702, and the other end of the rotating rod extends to the outside of the cavity and is connected to a knob 701; Multiple sets of telescopic rods 704, each set of telescopic rods 704 consists of two telescopic rods 704. The two ends of the telescopic rods 704 are respectively connected to the rotating column 8 and the connecting frame 6, and the two telescopic rods 704 in the same set are symmetrically arranged on both sides of the adjusting screw 705.

[0024] The specific usage method and working principle are as follows: Adjust the applicable mode of the centrifuge tube according to the actual requirements. Under normal conditions, the connecting frame 6 is far away from the fixed toothed ring 403. At this time, the rotating sleeve 401 is suitable for the installation, static placement and detection position conversion of the centrifuge tube. When it is necessary to shake the centrifuge tubes to mix them, the operator turns the knob 701. The knob 701 drives the rotating rod to rotate, which in turn drives the adjusting gear 702 to rotate. The adjusting gear 702 drives the transmission gear 703 to rotate, which in turn drives the adjusting screw 705 to rotate. The adjusting screw 705, in conjunction with the telescopic rod 704, drives the screw seat 706 to move away from the rotating column 8. The screw seat 706 drives the connection to move closer to the fixed gear ring 403, thereby making the drive gear 418 mesh with the fixed gear ring 403. The trigger wheel 415 and the trigger block 405 are also approximately located on the same circumference, thus achieving the shaking and mixing of the centrifuge tubes. When a reset is required, the operator turns the knob 701 in the opposite direction. The knob 701 drives the adjusting gear 702 to rotate in the opposite direction via the rotating rod. The adjusting gear 702 drives the adjusting screw 705 to rotate in the opposite direction via the transmission gear 703. The adjusting screw 705 drives the connecting frame 6 to reset via the screw seat 706.

[0025] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A botulinum toxin-like peptide detection device for cosmetic production, comprising a rotating column (8), characterized in that, The outer periphery of the rotating column (8) is provided with a clamping and shaking assembly (4) and multiple connecting frames (6) that can move synchronously. The clamping and shaking assembly (4) includes multiple rotating sleeves (401) that can rotate synchronously. Multiple guide wheels (408) for clamping centrifuge tubes are provided inside the rotating sleeves (401). A support groove (406) that can move in the vertical direction is provided below the rotating sleeves (401). The support groove (406) is used to support the bottom of the centrifuge tubes upward.

2. The botulinum toxin-like peptide detection device for cosmetic production according to claim 1, characterized in that, The connecting frame (6) consists of an upper horizontal part, a lower horizontal part and a vertical part. Multiple rotating sleeves (401) are arranged in a circular array on the outside of the rotating column (8). The rotating sleeves (401) are rotatably connected to the upper horizontal part, and the supporting groove seat (406) is slidably connected to the upper horizontal part. The rotating column (8) is provided with a base (2) at the bottom, and a constant temperature tank seat (3) is provided at the center of the top of the base (2). The rotating column (8) is rotatably connected to the constant temperature tank seat (3). The top of the rotating sleeve (401) is connected to a limiting ring, and the outer surface of the rotating sleeve (401) is provided with a threaded groove.

3. The botulinum toxin-like peptide detection device for cosmetic production according to claim 2, characterized in that, The clamping and shaking assembly (4) further includes: Multiple drive gears (418) are arranged in a circular array on the outer periphery of the rotating column (8), and the drive gears (418) are connected to the outer surface of the rotating sleeve (401); A fixed gear ring (403) is connected to the constant temperature tank (3), and multiple drive gears (418) are meshed with the fixed gear ring (403).

4. The botulinum toxin-like peptide detection device for cosmetic production according to claim 2, characterized in that, The clamping and shaking assembly (4) further includes: Multiple sets of movable rods (417), each set of movable rods (417) consists of two movable rods (417), the two movable rods (417) in the same set are symmetrically connected to the bottom of the support groove seat (406), and the bottom of the two movable rods (417) in the same set is connected to the same trigger wheel (415), and the movable rods (417) are slidably connected to the lower horizontal part; Multiple sets of second springs (416), each set of second springs (416) consists of two second springs (416), the second springs (416) are sleeved on the outer surface of the moving rod (417), and the two ends of the second springs (416) are respectively connected to the trigger wheel (415) and the lower horizontal part; The bottom ring (404) is connected to the bottom of the inner wall of the constant temperature bath (3). The top of the bottom ring (404) is connected to a plurality of trigger blocks (405) arranged in a circular array. The cross-sectional shape of the trigger block (405) is trapezoidal. The trigger block (405) can drive the trigger wheel (415) to move upward when the trigger wheel (415) rotates.

5. The botulinum toxin-like peptide detection device for cosmetic production according to claim 2, characterized in that, The clamping and shaking assembly (4) further includes: Multiple rotating rings (407) are sleeved on the outside of the rotating sleeve (401), and the rotating rings (407) can move vertically in the rotating sleeve (401); Multiple sets of push blocks (409), each set of push blocks (409) consists of multiple push blocks (409), and the multiple push blocks (409) in the same set are connected in a circular array at the bottom of the rotating ring (407); Multiple sets of push wheels (410) are provided, each set of push wheels (410) consists of multiple push wheels (410). The multiple push wheels (410) in the same set are arranged in a circular array outside the rotating sleeve (401). One side of the push wheel (410) is attached to one side of the push block (409). One side of the push block (409) is connected to a sliding rod (414). One end of the sliding rod (414) extends into the interior of the rotating sleeve (401) and is connected to one side of the attached guide wheel (408). A first spring (413) is sleeved on the outer surface of the sliding rod (414). The two ends of the first spring (413) are respectively connected to one side of the rotating sleeve (401) and one side of the push wheel (410).

6. The botulinum toxin-like peptide detection device for cosmetic production according to claim 5, characterized in that, The clamping and shaking assembly (4) further includes: Multiple threaded rings (402) are threadedly connected to a rotating sleeve (401), and the rotating ring (407) is rotatably connected to the bottom of the threaded rings (402); Multiple fixed rings (412) are connected to the outer surface of the rotating sleeve (401), and the fixed rings (412) are located below the threaded ring (402). Multiple fixed slide rods (411) arranged in a circumferential array are connected to the top of the fixed rings (412), and the push block (409) is slidably connected to the fixed slide rods (411).

7. The botulinum toxin-like peptide detection device for cosmetic production according to claim 6, characterized in that, The rotating column (8) has a cavity inside, and a shape switching component (7) is provided on the outer periphery of the rotating column (8). The shape switching component (7) includes: Multiple adjusting screws (705) are arranged in a circular array outside the rotating column (8), and the adjusting screws (705) are rotatably connected to the rotating column (8); Multiple lead screw seats (706) are arranged in a circular array outside the rotating column (8). One side of the lead screw seat (706) is connected to one side of the connecting frame (6). The lead screw seat (706) is connected to the adjusting lead screw (705) in a transmission connection. Multiple transmission gears (703) are arranged in a circular array within the cavity, and one end of the transmission gears (703) is connected to the adjusting screw (705).

8. The botulinum toxin-like peptide detection device for cosmetic production according to claim 7, characterized in that, The form switching component (7) also includes: An adjusting gear (702) is rotatably connected to the cavity, and the adjusting gear (702) is meshed with the transmission gear (703); A rotating rod is connected to the top of the adjusting gear plate (702), and the other end of the rotating rod extends to the outside of the cavity and is connected to a knob (701).

9. A botulinum toxin-like peptide detection device for cosmetic production according to claim 8, characterized in that, The form switching component (7) also includes: Multiple sets of telescopic rods (704), each set of telescopic rods (704) consists of two telescopic rods (704), the two ends of the telescopic rods (704) are connected to the rotating column (8) and the connecting frame (6) respectively, and the two telescopic rods (704) in the same set are symmetrically arranged on both sides of the adjusting screw (705).

10. The botulinum toxin-like peptide detection device for cosmetic production according to claim 1, characterized in that, Also includes: A protective shell (1) is connected to the top of the base (2), and two symmetrically distributed closed doors are provided on one side of the protective shell (1); The botulinum toxin-like peptide component detection mechanism (5) is located on one side of the top of the base (2) and consists of a lifting mechanism and a detection probe.

Images