Buttock cream with high water content and strong hydrophobicity and preparation method of buttock cream

Abstract

The invention relates to the technical field of skin care products, in particular to hip cream with high water content and high hydrophobicity and a preparation method of the hip cream. The composition comprises an oil phase, a water phase and an active matter, the oil phase comprises sealing grease, an emollient, wax, a co-emulsifier and an emulsifier; the water phase comprises water, a humectant, a stabilizer, a chelating agent, a preservative and a conditioner; the active matters comprise panthenol and bisabolol. According to the hip cream prepared by the invention, the content of water is greater than 35wt%, and meanwhile, the hip cream also has excellent hydrophobic performance; the emulsifier is selected from at least one of polyglycerol-2 dipolyhydroxystearate, polyglycerol-3 diisostearate and PEG-30 dipolyhydroxystearate, so that the high-temperature stability of the hip cream can be further improved.

Description

Technical Field

[0001] This invention relates to the field of skin care product technology, specifically to a diaper rash cream with high water content and strong hydrophobicity and its preparation method. Background Technology

[0002] Infants' skin barrier function is not yet fully developed, with a thin stratum corneum and high water content, making them vulnerable to external stimuli. Combined with the chemical irritation from urine and feces and the growth of microorganisms in the enclosed environment of diapers, diaper rash is highly prevalent, manifesting as redness, swelling, and even erosion of the buttocks. As a core protective product, diaper rash cream's core needs focus on the synergistic effect of isolating irritants, antibacterial and anti-inflammatory properties, and gentle nourishment. Currently, commercially available diaper rash creams mainly suffer from two problems: one type uses a water-in-oil emulsion system, which, while possessing some moisturizing properties, lacks sufficient protective film density, failing to effectively isolate irritants from urine and feces, and the emulsifiers are prone to triggering allergic reactions; the other type relies on ingredients such as petrolatum and zinc oxide to construct the protective layer, but its excessive occlusiveness leads to poor skin breathability, and the hygroscopic and astringent properties of zinc oxide can easily cause peeling and dryness, making it unsuitable for broken skin. Therefore, developing a diaper rash cream that combines highly effective protection, gentle low irritation, and a simple preparation process has become an urgent need in this field.

[0003] Chinese invention patent application CN108992356A proposes a diaper rash cream formula containing modified graphene oxide. Graphene enhances antibacterial properties, while zinc oxide and shea butter provide isolation and nourishment, thus addressing the weakness of traditional products in terms of sterilization. However, the preparation of the modified graphene requires a low-temperature (-78°C) reaction, resulting in high process complexity, and the retention of petrolatum does not fully improve the insufficient breathability. Therefore, developing a diaper rash cream that combines high-efficiency protection, gentle and low-irritation properties, and a simple preparation process has become an urgent need in this field. Summary of the Invention

[0004] The first aspect of this invention provides a diaper rash cream with high water content and strong hydrophobicity, comprising an oil phase, an aqueous phase, and active ingredients; the oil phase comprises: occlusive oils, emollients, waxes, co-emulsifiers, and emulsifiers; the aqueous phase comprises water, humectants, stabilizers, chelating agents, preservatives, and conditioning agents; and the active ingredients comprise panthenol and bisabolol.

[0005] Optionally, by weight percentage, the diaper rash cream contains 0.1-1% active ingredients, 40-60% oil phase, and the balance is made up of aqueous phase.

[0006] The occlusive grease includes at least one of petrolatum, hydrogenated polyisobutylene, white oil, lanolin, phytosterol esters, and polyisobutylene.

[0007] The emollient includes at least one of caprylic / capric triglyceride, diethyl sebacate, isononyl isononyl ester, propylene glycol caprylate, diisopropyl adipate, and neopentyl glycol diheptanoate.

[0008] The waxes include at least one of microcrystalline wax, beeswax, ceresin wax, pure ceresin wax, polyethylene wax, and carnauba wax.

[0009] The co-emulsifier includes at least one of glyceryl behenate / eicosyl ester, glyceryl stearate, glyceryl palmitate, glyceryl myristate, PEG-100 stearate, and sorbitan stearate.

[0010] The emulsifier includes at least one of polyglycerol-3 diisostearate, PEG-30 dihydroxystearate, polyglycerol-4 diisostearate, polyglycerol-6 diisostearate, polyoxyethylene sorbitan monostearate (Tween 60), sorbitan monostearate (Span 60), and polyglycerol-2 diisostearate.

[0011] The emulsifier includes at least one of polyglycerol-2 dihydroxystearate, polyglycerol-3 diisostearate, and PEG-30 dihydroxystearate.

[0012] Optionally, the emulsifier includes polyglycerol-3 diisostearate and PEG-30 dihydroxystearate.

[0013] The moisturizer includes at least one of glycerin, propylene glycol, butylene glycol, 1,3-propanediol, sorbitol, and betaine.

[0014] The stabilizer includes at least one of magnesium sulfate heptahydrate, anhydrous magnesium sulfate, calcium chloride, magnesium chloride, zinc sulfate, and aluminum chloride.

[0015] The chelating agent includes at least one of disodium EDTA, tetrasodium EDTA, citric acid, sodium citrate, dipotassium ethylenediaminetetraacetate, and hydroxyethyl diphosphate.

[0016] The preservative includes at least one of p-hydroxyacetophenone, phenoxyethanol, hexanediol, octanediol, sodium benzoate, and potassium sorbate.

[0017] The conditioning agent includes at least one of dipotassium glycyrrhizate, glycyrrhetinic acid, allantoin, sodium hyaluronate, and asiaticoside.

[0018] The weight ratio of panthenol to bisabolol is (3-8):1.

[0019] Optionally, the weight ratio of panthenol to bisabolol is (4-7):1.

[0020] The weight ratio of the waxes to the co-emulsifier is 3:(2.2-3).

[0021] Optionally, the weight ratio of the wax to the co-emulsifier is 3:(2.3-2.7).

[0022] The water content in the diaper rash cream is >35wt%.

[0023] Optionally, the water content in the diaper rash cream is 35-65 wt%.

[0024] The emulsifiers include polyglycerol-3 diisostearate and PEG-30 dihydroxystearate.

[0025] The weight ratio of the occlusive oil to the emollient is (1.4-3.8):1.

[0026] Optionally, the weight ratio of the occlusive oil to the emollient is (2-4):1.

[0027] The diaper rash cream prepared by this invention has a water content >35wt% and also exhibits excellent hydrophobic properties. This diaper rash cream is based on a water-in-oil system, firstly through the polyglycerol-3 in the oil phase... Water-in-oil emulsifiers such as diisostearate disperse the high-content aqueous phase into tiny, uniform droplets under homogeneous conditions, tightly encapsulating them within the oil phase and preventing direct exposure of the aqueous phase to the system surface. Simultaneously, the composite system of microcrystalline wax, petrolatum, and glyceryl behenate / eicosanoate in the oil phase plays a crucial synergistic role—petrolatum provides basic sealing, microcrystalline wax adjusts the structural hardness of the oil phase to enhance film-forming properties, and glyceryl behenate / eicosanoate further optimizes the surface characteristics of the oil phase and improves the contact angle. Together, these three components form a continuous and dense hydrophobic film on the system surface. Furthermore, magnesium sulfate heptahydrate in the aqueous phase increases the osmotic pressure and freezing point of the aqueous phase, further enhancing the stability of the oil phase encapsulation of the aqueous droplets and preventing system stratification or hydrophobic film damage caused by high water content. Ultimately, through the synergistic effect of "emulsifier-stabilized encapsulation, oil-phase composite system film formation, and aqueous phase component-assisted stabilization," a balance between high water content and excellent hydrophobicity is achieved.

[0028] The second aspect of the present invention provides a method for preparing a diaper rash cream with high water content and strong hydrophobicity, comprising the following steps: mixing an oil phase, an aqueous phase and an active ingredient separately; adding the aqueous phase to the oil phase and mixing to obtain a premix; and adding the active ingredient to the premix and mixing.

[0029] Beneficial effects 1. The diaper rash cream prepared by this invention has a water content >35wt% and also has excellent hydrophobic properties.

[0030] 2. The emulsifier of this invention is selected from at least one of polyglycerol-2 dihydroxystearate, polyglycerol-3 diisostearate and PEG-30 dihydroxystearate, which can further improve the high temperature stability of the diaper rash cream.

[0031] 3. The emulsifier of the present invention includes both polyglycerol-3 diisostearate and PEG-30 dihydroxystearate, which can further improve the comfort of use on the basis of stability.

[0032] 4. By limiting the weight ratio of waxes and co-emulsifiers to 3:(2.2-3), the present invention can further improve the low-temperature stability of the diaper rash cream. Attached Figure Description

[0033] Figure 1 The results of the contact angle test for the diaper rash cream in Example 2 are shown. Detailed Implementation

[0034] Examples 1-2, Comparative Examples 1-4 A diaper rash cream with high water content and strong hydrophobicity is prepared by the following raw materials by weight percentage, as shown in Table 1, where blank spaces indicate no addition.

[0035] Table 1

[0036] A method for preparing a diaper rash cream with high water content and strong hydrophobicity: the oil phase is mixed and heated to 80°C; the water phase is mixed and heated to 75°C; the water phase is slowly added to the oil phase under homogenization conditions and homogenized until homogeneous; then the active raw material is added and homogenized until homogeneous.

[0037] Performance testing methods and data The diaper rash creams prepared in the examples and comparative examples were subjected to the following performance tests, and the test data are listed in Tables 2-4.

[0038] Contact angle test: Approximately 0.5g of sample was evenly applied to a glass plate with an area of ​​2cm × 2cm. A drop of purified water was placed on the glass plate after the sample was applied, and the contact angle was measured (the average of three measurements was taken). The test results are shown in Table 2. The results show that the diaper rash cream prepared in the examples has a contact angle > 95°, exhibiting excellent hydrophobic properties. In particular, the diaper rash cream of Example 2 has a contact angle as high as 102°. Figure 1 ).

[0039] Stability: The stability of the diaper rash cream was tested under different conditions. The test conditions and results are shown in Table 3.

[0040] Table 2

[0041] Table 3

Claims

1. A diaper rash cream with high water content and strong hydrophobicity, characterized in that, The components include an oil phase, an aqueous phase, and active ingredients; the oil phase includes: occlusive oils, emollients, waxes, co-emulsifiers, and emulsifiers; the aqueous phase includes water, humectants, stabilizers, chelating agents, preservatives, and conditioning agents; the active ingredients include panthenol and bisabolol.

2. The diaper rash cream with high water content and strong hydrophobicity according to claim 1, characterized in that, The water content in the diaper rash cream is >35wt%.

3. The diaper rash cream with high water content and strong hydrophobicity according to claim 2, characterized in that, The weight ratio of the occlusive oil to the emollient is (1.4-3.8):

1.

4. The diaper rash cream with high water content and strong hydrophobicity according to claim 3, characterized in that, The weight ratio of the waxes to the co-emulsifier is 3:(2.2-3).

5. The diaper rash cream with high water content and strong hydrophobicity according to claim 4, characterized in that, The emulsifier includes at least one of polyglycerol-2 dihydroxystearate, polyglycerol-3 diisostearate, and PEG-30 dihydroxystearate.

6. The diaper rash cream with high water content and strong hydrophobicity according to claim 5, characterized in that, The emulsifiers include polyglycerol-3 diisostearate and PEG-30 dihydroxystearate.

7. The diaper rash cream with high water content and strong hydrophobicity according to claim 1, characterized in that, By weight percentage, the components include: 0.1-1% active ingredient, 40-60% oil phase, and the balance being aqueous phase.

8. The diaper rash cream with high water content and strong hydrophobicity according to claim 7, characterized in that, The weight ratio of panthenol to bisabolol is (3-8):

1.

9. The diaper rash cream with high water content and strong hydrophobicity according to claim 1, characterized in that, The co-emulsifier includes at least one of glyceryl behenate / eicosyl ester, glyceryl stearate, glyceryl palmitate, glyceryl myristate, PEG-100 stearate, and sorbitan stearate.

10. A method for preparing a diaper rash cream with high water content and strong hydrophobicity according to any one of claims 1-9, characterized in that, Includes the following steps: The oil phase, aqueous phase, and active ingredient are mixed separately. The aqueous phase is then added to the oil phase and mixed thoroughly to obtain a premix. Add the active ingredient to the premix and mix well.

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