Rapid acne-removing composition containing colloidal sulfur as well as preparation method and application of rapid acne-removing composition

Abstract

The invention relates to the technical field of cosmetics, in particular to a rapid acne-removing composition containing colloidal sulfur as well as a preparation method and application of the rapid acne-removing composition. The invention relates to a rapid acne-removing composition containing colloidal sulfur. The rapid acne-removing composition is prepared from the colloidal sulfur, cyclodextrin inclusion licochalcone A and hydroxyapatite, the invention relates to a preparation method of a rapid acne-removing composition containing colloidal sulfur. The preparation method comprises the following steps: S1, preparing cyclodextrin inclusion licochalcone A; s2, constructing a colloidal sulfur-hydroxyapatite composite system; mixing and preparation: mixing the cyclodextrin inclusion licochalcone A prepared in the step S1 with the composite dispersion system prepared in the step S2, then adding dermatologically acceptable auxiliary materials, and homogenizing to obtain a target composition; the acne-removing mask has the beneficial effects that the acne-removing mask has a synergistic effect and can quickly remove acnes; slow-release synergism is realized, and irritation is reduced; repairing the skin barrier; the preparation method is simple.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to a fast-acting acne-removing composition containing colloidal sulfur, its preparation method, and its application. Background Technology

[0002] Acne (commonly known as pimples) is a common chronic inflammatory disease of the hair follicles and sebaceous glands. Its pathogenesis is complex and mainly related to factors such as excessive sebum secretion, abnormal follicular keratinization, proliferation of Propionibacterium acnes, and inflammatory response. Currently, most acne treatment products on the market use single active ingredients or simple compound ingredients, which have problems such as slow acne treatment effect, strong irritation, easy recurrence, and potential damage to the skin barrier.

[0003] Sulfur is a traditional acne-fighting ingredient. Current technology often uses it to encapsulate it in gum arabic to create colloidal sulfur, improving its water solubility and reducing its volatility and irritation. However, gum arabic is not heat-resistant and has excessive water solubility, resulting in poor stability of this type of colloidal sulfur in oxygen / water systems. It also suffers from short duration of action and residual irritation. Glycyrrhizin chalcone A has excellent anti-inflammatory and soothing effects, but its high lipid solubility, poor water solubility, and tendency to crystallize limit its application.

[0004] Although hydroxyapatite has porous adsorption properties and can adsorb excess oil, current technology has not been able to reasonably combine it with colloidal sulfur and glycyrrhizin A, so it is impossible to use its adsorption properties to achieve sustained release and enhanced efficacy of active ingredients, and it is also difficult to form a synergistic effect to improve acne treatment and reduce irritation.

[0005] Therefore, developing a composition that can achieve rapid acne removal, sustained-release synergistic effect, reduced irritation, and repair of the skin barrier has significant practical importance and market value. Summary of the Invention

[0006] To address the shortcomings of existing technologies, one of the objectives of this invention is to provide a fast-acting acne-removing composition containing colloidal sulfur. This composition achieves rapid acne removal, sustained-release enhancement, and reduced irritation through the synergistic combination of specific ingredients. It also repairs the skin's physical barrier and is suitable for all types of acne-prone skin, especially for fragile acne-prone skin.

[0007] The second objective of this invention is to provide a method for preparing a rapid acne-removing composition containing colloidal sulfur.

[0008] The third objective of this invention is to provide an application of a fast-acting acne-removing composition containing colloidal sulfur in acne-removing cosmetics.

[0009] One of the objectives of this invention is achieved through the following technical solution: A rapid acne-removing composition containing colloidal sulfur includes: colloidal sulfur, cyclodextrin encapsulated with glycyrrhizin A, and hydroxyapatite.

[0010] Preferably, the contents of the colloidal sulfur, cyclodextrin-encapsulated glycyrrhizin A, and hydroxyapatite by weight percentage are 0.5%-5%, 0.2%-3%, and 0.2%-4%, respectively.

[0011] Preferably, the contents of the colloidal sulfur, cyclodextrin-encapsulated glycyrrhizin A, and hydroxyapatite by weight percentage are 1%-4%, 0.5%-3%, and 0.5%-3%, respectively. At this ratio, the synergistic effect of each component is optimal, which can ensure rapid acne removal effect, minimize irritation, and achieve good sustained-release effect and skin barrier repair effect.

[0012] Preferably, in the cyclodextrin-encapsulated glycyrrhizin A, the molar ratio of cyclodextrin to glycyrrhizin A is 1:1 to 5:1.

[0013] Preferably, in the cyclodextrin inclusion complex of glycyrrhizin chalcone A, the molar ratio of cyclodextrin to glycyrrhizin chalcone A is 2:1-3:1. Cyclodextrin inclusion technology significantly improves the water solubility and stability of glycyrrhizin chalcone A, prevents crystallization, enhances bioavailability, and strengthens its anti-inflammatory and soothing effects. The cyclodextrin can be selected from one or more of α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, or their derivatives, preferably β-cyclodextrin, which has good inclusion effect, high safety, and wide application in the cosmetics field.

[0014] Preferably, dermatologically acceptable excipients are also included.

[0015] Preferably, the excipients are one, two or more of the following: humectants, thickeners, emulsifiers, pH adjusters and preservatives.

[0016] The second objective of this invention is achieved through the following technical solution: A method for preparing a rapid acne-removing composition containing colloidal sulfur includes the following steps: S1. Preparation of cyclodextrin-encapsulated glycyrrhizin A: Glycyrrhizin A was encapsulated with cyclodextrin using a saturated aqueous solution method, grinding method, or ultrasonic method to prepare cyclodextrin-encapsulated glycyrrhizin A; S2. Constructing a colloidal sulfur-hydroxyapatite composite system: Colloidal sulfur and porous hydroxyapatite are mixed in a liquid medium, so that the colloidal sulfur particles are physically adsorbed into the porous structure of hydroxyapatite to form a composite dispersion system; S3. Mixing and Formulation: The cyclodextrin-encapsulated glycyrrhizin A obtained in step S1 is mixed with the composite dispersion system obtained in step S2, and then dermatologically acceptable excipients are added. The mixture is homogenized to obtain the target composition.

[0017] Preferably, in step S1, the inclusion method is an ultrasonic-assisted saturated aqueous solution method, specifically: cyclodextrin is dissolved in water to form a saturated or near-saturated solution, an ethanol solution of glycyrrhizin chalcone A is added, and the mixture is ultrasonically treated at 40-60°C for 30-120 minutes, followed by low-temperature refrigeration for crystallization, filtration, and drying to obtain the inclusion powder.

[0018] The third objective of this invention is achieved through the following technical solution: A fast-acting acne-removing composition containing colloidal sulfur is used in the preparation of acne-removing cosmetics, in the form of a serum, gel, lotion, cream, mask, or topical applicator.

[0019] The beneficial effects of this invention are as follows: 1. Synergistic Effect for Rapid Acne Removal: This invention achieves a synergistic effect through the rational combination of colloidal sulfur, cyclodextrin-encapsulated glycyrrhizin A, and hydroxyapatite. Colloidal sulfur directly inhibits the growth of Propionibacterium acnes and reduces sebum secretion; cyclodextrin-encapsulated glycyrrhizin A improves bioavailability, enabling it to exert a more efficient and gentle anti-inflammatory and soothing effect, relieving acne redness and discomfort; hydroxyapatite absorbs excess oil and unclogs pores, creating favorable conditions for other active ingredients to exert their effects. The synergistic effect of these three ingredients rapidly improves acne inflammation and shortens the acne treatment cycle.

[0020] 2. Sustained release and enhanced efficacy, reduced irritation: The porous structure of hydroxyapatite can form a complex system with colloidal sulfur, achieving sustained release of colloidal sulfur, prolonging its action time, and reducing the concentration of colloidal sulfur in direct contact with the skin, thus significantly reducing its irritation.

[0021] 3. Repairing the skin barrier: Hydroxyapatite has excellent biocompatibility and can form a breathable protective film on the skin surface, helping to repair the physical barrier of fragile skin. It solves the problem that traditional acne treatment products easily damage the skin barrier. Long-term use can improve skin texture and reduce the recurrence rate of acne.

[0022] 4. The preparation method is simple and easy to industrialize: The preparation method of the present invention has simple steps, does not require complex equipment, and has mild reaction conditions, making it suitable for large-scale industrial production and having good market application prospects. Attached Figure Description

[0023] Figure 1 This is a comparison chart showing the change in papule volume at the red and swollen area of ​​the face of one of the experimental subjects in Example 1 of the acne treatment test, before and 8 hours after use. Detailed Implementation

[0024] The following is a further explanation with reference to specific implementation methods: The formulations for Examples 1-3 are shown in Table 1.

[0025] Table 1 Formulation Table

[0026] Preparation methods of Examples 1-3: 1. Preparation of cyclodextrin-included glycyrrhizin A: Weigh 10g of β-cyclodextrin and dissolve it in 90g of hot water at 60℃, stirring to form a nearly saturated solution. Separately, dissolve 2g of glycyrrhizin A in 10g of anhydrous ethanol. While stirring, slowly add the ethanol solution of glycyrrhizin A dropwise to the cyclodextrin aqueous solution. Place the mixture in an ultrasonic cleaner (500W power) and sonicate at 55℃ for 60 minutes. Then transfer the solution to a 4℃ refrigerator and allow it to stand for 12 hours to precipitate the inclusion complex. Filter the precipitate, wash it twice with a small amount of ethanol, and dry it under vacuum to obtain cyclodextrin-included glycyrrhizin A.

[0027] 2. Preparation of hydroxyapatite-colloidal sulfur composite system: 4% colloidal sulfur was added to deionized water and ultrasonically dispersed for 15 min at 250 W to obtain a uniform colloidal sulfur dispersion. Then, 3% hydroxyapatite was slowly added to the dispersion and stirred at 250 r / min at 30 °C for 45 min to adsorb the precipitate. The precipitate was collected by centrifugation and vacuum dried at 50 °C for 3 h to obtain the hydroxyapatite-colloidal sulfur composite system.

[0028] 3. Mixing and Formulation: Add glycerin, hyaluronic acid, carbomer, and phenoxyethanol to deionized water, heat to 80℃, stir to dissolve, homogenize, keep warm for 30 min, then cool to 45℃, add the hydroxyapatite-colloidal sulfur complex system prepared in step 2 and the cyclodextrin-encapsulated glycyrrhizin A prepared in step 1, stir evenly at a stirring speed of 250 r / min for 20 min to obtain a fast acne-removing essence.

[0029] Comparative Example 1: The step of “preparing the hydroxyapatite-colloidal sulfur composite system” was omitted. Colloidal sulfur and hydroxyapatite were directly added to the aqueous matrix, and the remaining steps were the same as in Example 1.

[0030] Comparative Example 2: No hydroxyapatite was added; colloidal sulfur was directly added to the formulation, and everything else was the same as in Example 1.

[0031] Comparative Example 3: Unencapsulated glycyrrhizin A powder was added directly, and the remaining steps were the same as in Example 1.

[0032] Stability test: The serums from Examples 1-3 and Comparative Examples 1-3 were stored at 4°C for refrigeration, 25°C for room temperature, and 45°C for 3 months, respectively. The state of the system was observed, and the results are recorded in Table 2.

[0033] Table 2 System Status

[0034] After 3 months, no stratification, precipitation, or discoloration was observed in groups 1, 2, and 3 of Examples. In contrast, groups 1 and 2 showed colloidal sulfur agglomeration, while group 3 showed stratification and discoloration, indicating that the proportions and composite system process of this invention can significantly improve stability.

[0035] Irritation-patch test Test substances: Examples 1-3 and Comparative Examples 1-2 of the present invention; Participants: A total of 32 participants, including 8 males and 24 females, aged 20-40 years, who met the criteria for voluntary participation. Test methods: Examples 1-3 and Comparative Examples 1-2 adopted a closed test method. The test substance was placed in a suitable patch applicator and applied to the flexor side of the subject's arm with hypoallergenic adhesive tape. The subject was then gently pressed with the palm of the hand to make it evenly applied to the skin for 24 hours. The blank control group did not use the product. Results: The test apparatus was removed after 24 hours, and skin reactions were observed and recorded at 0.5 h, 24 h, and 48 h. The severity of adverse skin reactions is shown in Table 3, and the test results are shown in Table 4.

[0036] Table 3. Grading Criteria for Skin Reaction in Occlusive Patch Tests

[0037] Table 4 Results of human skin patch test

[0038] No allergic or irritant reactions were observed in patch tests of Examples 1, 2, and 3 (irritation level 0). In Comparative Examples 1 and 2, subjects showed mild redness or erythema 0 h, 24 h, and 48 h after removal of the test apparatus, which resolved after 48 h of drug withdrawal. This indicates that the hydroxyapatite and composite system process can effectively reduce irritation in spot application scenarios.

[0039] Human body acne treatment effect test: Subjects: Ninety patients aged 18-35 years with a certain number of pimples and erythematous papular acne on their faces were selected, excluding nodules or cysts that were difficult to improve with clinical preparations. They were randomly divided into 6 groups of 15 each, using the rapid acne-removing essences of Examples 1-3, Comparative Examples 1-2, and the blank control group, respectively. The corresponding essences were used morning and evening after cleansing, and no other cosmetics were allowed during this period, for one week. Images were acquired and analyzed using the Miravex Antera 3D® CS multi-functional 3D skin imaging analyzer, recording changes in papule volume at the erythematous sites before use, 8 hours after use, and 3 days after use (e.g., ...). Figure 1Transepidermal water loss (TEWL) values ​​were measured using the Courage+Khazaka Tewameter®™ Hex probe. Laboratory researchers counted acne lesions on the subjects' facial areas and calculated the changes in lesion count after 3 and 7 days of use. Simultaneously, after 7 days of use, subjects conducted self-assessments to evaluate whether the sample had immediate acne-reducing, soothing, and oil-controlling effects. A 5-point scale was used, with 3 points or higher indicating agreement. Subjects' agreement levels were calculated. Test results are shown in Table 5, and subject self-assessment results are shown in Table 6.

[0040] Papule volume change rate = [(Papule volume after use - Papule volume before use) / Papule volume before use] × 100%.

[0041] Change rate of acne lesion quantity = [(number of acne lesions after use - number of acne lesions before use) / number of acne lesions before use] × 100%.

[0042] TWEL value change rate = [(Average transdermal water loss of 10 people in each group after using the test sample - Average transdermal water loss of 10 people in each group before using the test sample (T0)) / Average transdermal water loss of 10 people in each group before using the test sample (T0)] × 100% Blank control: 3g glycerin, 0.04g sodium hyaluronate, 2g 1,3-butanediol, 0.5g fentanyl ketone, 0.5g hexanediol, 0.25g ammonium acryloyldimethyl taurate / behenol polyether-25 methacrylate crosspolymer, 0.5g hydroxyethylpiperazine ethane sulfonic acid, 0.06g xanthan gum, 100g deionized water, mixed thoroughly.

[0043] Table 5 Test Results

[0044] Table 6. Subjects' self-assessment

[0045] As shown in Table 5, the serum obtained by the present invention is superior to the prior art in terms of papule volume change rate, acne lesion number change rate, and TWEL value change rate. In other words, the serum obtained by the present invention performs excellently in relieving acne redness and swelling, repairing damaged skin, and retaining moisture.

[0046] Table 6 shows that subjects using the serum obtained by this invention reported reduced redness, improved acne treatment, reduced acne severity, and reduced swelling and pain in the acne area, confirming the efficacy of the serum in relieving acne redness and repairing damaged skin. Furthermore, the subjects' self-assessment also confirmed that the serum has oil-controlling, skin-repairing, and gentle, non-irritating properties.

[0047] The embodiments and descriptions above are merely illustrative of the principles and preferred embodiments of the present invention. Various changes and modifications may be made to the present invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as claimed.

Claims

1. A fast acne-removing composition containing colloidal sulfur, characterized in that, include: Colloidal sulfur, cyclodextrin encapsulating glycyrrhizin A and hydroxyapatite.

2. The colloidal sulfur-containing rapid acne-removal composition according to claim 1, characterized by: The contents of the colloidal sulfur, cyclodextrin-encapsulated glycyrrhizin A, and hydroxyapatite by weight percentage are 0.5%-5%, 0.2%-3%, and 0.2%-4%, respectively.

3. The rapid acne-removing composition containing colloidal sulfur according to claim 2, characterized in that: The contents of the colloidal sulfur, cyclodextrin-encapsulated glycyrrhizin A, and hydroxyapatite by weight percentage are 1%-4%, 0.5%-3%, and 0.5%-3%, respectively.

4. The rapid acne-removing composition containing colloidal sulfur according to claim 1, characterized in that: In the cyclodextrin-encapsulated glycyrrhizin A, the molar ratio of cyclodextrin to glycyrrhizin A is 1:1-5:

1.

5. The rapid acne-removing composition containing colloidal sulfur according to claim 4, characterized in that: In the cyclodextrin-encapsulated glycyrrhizin A, the molar ratio of cyclodextrin to glycyrrhizin A is 2:1-3:

1.

6. The rapid acne-removing composition containing colloidal sulfur according to claim 1, characterized in that: It also includes dermatologically acceptable excipients.

7. The rapid acne-removing composition containing colloidal sulfur according to claim 6, characterized in that: The excipients are one, two, or more of the following: humectants, thickeners, emulsifiers, pH adjusters, and preservatives.

8. A method for preparing a rapid acne-removing composition containing colloidal sulfur as described in claim 1, characterized in that, Includes the following steps: S1. Preparation of cyclodextrin-encapsulated glycyrrhizin A: Glycyrrhizin A was encapsulated with cyclodextrin using a saturated aqueous solution method, grinding method, or ultrasonic method to prepare cyclodextrin-encapsulated glycyrrhizin A; S2. Constructing a colloidal sulfur-hydroxyapatite composite system: Colloidal sulfur and porous hydroxyapatite are mixed in a liquid medium, so that the colloidal sulfur particles are physically adsorbed into the porous structure of hydroxyapatite to form a composite dispersion system; S3. Mixing and Formulation: The cyclodextrin-encapsulated glycyrrhizin A obtained in step S1 is mixed with the composite dispersion system obtained in step S2, and then dermatologically acceptable excipients are added. The mixture is homogenized to obtain the target composition.

9. The method for preparing the colloidal sulfur-containing rapid acne-removing composition according to claim 8, characterized in that: In step S1, the inclusion method is the ultrasonic-assisted saturated aqueous solution method: cyclodextrin is dissolved in water to form a saturated or near-saturated solution, an ethanol solution of glycyrrhizin chalcone A is added, and the mixture is ultrasonically treated at 40-60°C for 30-120 minutes. Subsequently, the mixture is refrigerated at low temperature for crystallization, filtered, and dried to obtain the inclusion powder.

10. A fast-acting acne-removing composition containing colloidal sulfur as described in claim 1, used in the preparation of acne-removing cosmetics, wherein the dosage form is one of serum, gel, lotion, cream, mask, or topical application stick.

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