Material for improving adhesiveness of hot melt adhesive paste and preparation method thereof

Abstract

The invention discloses a material for improving adhesion of a hot melt adhesive sticker and a preparation method thereof, and belongs to the field of adhesion of hot melt adhesive stickers, and the material is prepared from the following raw materials: SIS, naphthenic oil, an antioxidant, hydrogenated C5 resin and polyethylene glycol. According to the invention, after polyethylene glycol is added by utilizing a physical mixing method, the hydrophilicity of the system is improved, and the solubility, compatibility and release performance of a hydrophilic drug in the system are further enhanced.

Description

Technical Field

[0001] This invention relates to the field of hot melt adhesive bonding, and more specifically to a material for improving the adhesion of hot melt adhesive and its preparation method. Background Technology

[0002] Patches are the most common dosage form, referring to thin, flexible preparations made from active pharmaceutical ingredients and suitable materials, applied to the skin to produce local or systemic effects. Patches play an important role in modern medicine, providing a visible and well-compliant method of drug delivery. Materials used to prepare patches can be broadly classified into polyacrylate type, polyisobutylene type, silicone type, and styrene-isoprene-styrene block copolymer type.

[0003] SIS (styrene-isoprene-styrene) possesses unique environmental properties and high processability. As a non-polar polymer, SIS is suitable for loading lipophilic drugs based on the principle of "like dissolves like." Highly lipophilic drugs exhibit better compatibility with SIS, resulting in faster drug diffusion and release rates. However, the non-polar nature of SIS significantly limits its ability to load and release hydrophilic drugs, and may also cause decreased adhesion due to poor perspiration.

[0004] Therefore, providing a material and its preparation method for improving the adhesion performance of hot melt adhesive tape is a problem that urgently needs to be solved by those skilled in the art. Summary of the Invention

[0005] In view of this, the present invention provides a material for improving the adhesion of hot melt adhesive and a method for preparing the same. The present invention enhances the polarity of the system by introducing hydrophilic substances or polar groups.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: A material for improving the adhesion of hot melt adhesive tapes comprises the following raw materials by weight percentage: Styrene-isoprene-styrene 20-30%, naphthenic oil 30-40%, antioxidant 1-5%, resin 20-30%, polyethylene glycol 400 1-5%.

[0007] Furthermore, the antioxidant is antioxidant 1010; The resin is a hydrogenated C5 resin.

[0008] The molecular weight of the polyethylene glycol is 400-2000.

[0009] This invention also provides a method for preparing a material that improves the adhesion of hot melt adhesive, comprising the following steps: (1) Weigh each raw material according to the above mass percentages; (2) Add styrene-isoprene-styrene, antioxidant and naphthenic oil into the reaction vessel, and place the reaction vessel in an electric heating mantle for heating; (3) Observe the state inside the reaction vessel. When the styrene-isoprene-styrene changes from white particles to transparent particles, stir until the reaction vessel contains a uniform transparent liquid. (4) Add resin to the reaction vessel, adjust the stirring speed to 50-100 rpm and heat and stir for 5-15 min; (5) Add polyethylene glycol to the reaction vessel and stir until the liquid in the flask is transparent to obtain a material that improves the adhesion of hot melt adhesive tape.

[0010] Furthermore, the heating temperature in step (2) is 170-180℃, and the heating time is 20-40min.

[0011] Furthermore, the stirring rate in step (3) is 30-80 rpm and the stirring time is 20-40 min.

[0012] Furthermore, the heating temperature in step (4) is 120°C.

[0013] Furthermore, the stirring rate in step (5) is 60-120 rpm and the stirring time is 5-15 min.

[0014] The beneficial effects of this invention are as follows: by adding polyethylene glycol through physical mixing, the hydrophilicity of the system is improved, thereby enhancing the solubility, compatibility and release performance of hydrophilic drugs in the system. Detailed Implementation

[0015] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0016] Example 1: A material for improving the adhesion of hot melt adhesive tape (1) Weigh out 30% SIS, 30% naphthenic oil, 5% 1010 antioxidant, 30% hydrogenated C5 resin, and 5% polyethylene glycol 400 by mass percentage; (2) Add SIS, antioxidant and naphthenic oil to the reaction vessel, and place the reaction vessel in an electric heating mantle and heat at 170°C for 30 min; (3) Observe the state inside the reaction vessel. When the SIS changes from white particles to transparent particles, start stirring at a rate of 50 rpm for 30 minutes until the SIS and oil are evenly mixed and the reaction vessel contains a uniform transparent liquid. (4) Add hydrogenated C5 resin to the reaction vessel and heat and stir at 120°C and 70 rpm for 10 min; (5) Add polyethylene glycol 400 to the reaction vessel and continue stirring at 80 rpm for 10 min until it becomes a transparent liquid, thus obtaining a material that improves the adhesion of hot melt adhesive tape.

[0017] The properties of the prepared material were compared with those of polyethylene glycol 400, and the results are shown in Table 1.

[0018] Table 1

[0019] Example 2: A material for improving the adhesion of hot melt adhesive tape (1) Weigh out 20% SIS, 40% naphthenic oil, 5% 1010 antioxidant, 30% hydrogenated C5 resin, and 5% polyethylene glycol 600; (2) Add SIS, antioxidant and naphthenic oil to the reaction vessel, and place the reaction vessel in an electric heating mantle and heat at 170°C for 30 min; (3) Observe the state inside the reaction vessel. When the SIS changes from white particles to transparent particles, start stirring at a rate of 50 rpm for 30 minutes until the SIS and oil are evenly mixed and the reaction vessel contains a uniform transparent liquid. (4) Add hydrogenated C5 resin to the reaction vessel and heat and stir at 120°C and 70 rpm for 10 min; (5) Add polyethylene glycol 600 to the reaction vessel and continue stirring at 80 rpm for 10 min until it becomes a transparent liquid, thus obtaining a material that improves the adhesion of hot melt adhesive.

[0020] The performance of the prepared material was compared with that of polyethylene glycol 600, and the results are shown in Table 2.

[0021] Table 2

[0022] Example 3: A material for improving the adhesion of hot melt adhesive tape (1) Weigh out 25% SIS, 35% naphthenic oil, 5% 1010 antioxidant, 30% hydrogenated C5 resin, and 5% polyethylene glycol 2000; (2) Add SIS, antioxidant and naphthenic oil to the reaction vessel, and place the reaction vessel in an electric heating mantle and heat at 180°C for 30 min; (3) Observe the state inside the reaction vessel. When the SIS changes from white particles to transparent particles, start stirring at a rate of 50 rpm for 30 minutes until the SIS and oil are evenly mixed and the reaction vessel contains a uniform transparent liquid. (4) Add hydrogenated C5 resin to the reaction vessel and heat and stir at 120°C and 70 rpm for 10 min; (5) Add polyethylene glycol 2000 to the reaction vessel and continue stirring at 80 rpm for 10 min until it becomes a transparent liquid, thus obtaining a material that improves the adhesion of hot melt adhesive.

[0023] The performance of the prepared material was compared with that of polyethylene glycol 2000, and the results are shown in Table 3.

[0024] Table 3

[0025] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. A material for improving the adhesion of hot melt adhesive tape, characterized in that, Including the following raw materials by mass percentage: Styrene-isoprene-styrene 20-30%, naphthenic oil 30-40%, antioxidant 1-5%, resin 20-30%, polyethylene glycol 1-5%.

2. The material for improving the adhesion of hot melt adhesive according to claim 1, wherein The antioxidant is antioxidant 1010; The resin is hydrogenated C5 resin; The molecular weight of the polyethylene glycol is 400-2000.

3. A method for preparing a material for improving the adhesion of hot melt adhesive, characterized by, Includes the following steps: (1) Weigh each raw material according to the mass percentage as described in claim 1 or 2; (2) Add styrene-isoprene-styrene, antioxidant and naphthenic oil into the reaction vessel, and place the reaction vessel in an electric heating mantle for heating; (3) Observe the state inside the reaction vessel. When the styrene-isoprene-styrene changes from white particles to transparent particles, stir until the reaction vessel contains a uniform transparent liquid. (4) Add resin to the reaction vessel, adjust the stirring speed to 50-100 rpm and heat and stir for 5-15 min; (5) Add polyethylene glycol to the reaction vessel and stir until the liquid in the flask is transparent to obtain a material that improves the adhesion of hot melt adhesive tape.

4. The method of claim 3, wherein the material is prepared by mixing the tackifier and the wax in a weight ratio of 1:0.1 to 1:0.

5. The heating temperature in step (2) is 170-180℃ and the heating time is 20-40min.

5. The method for preparing a material for improving the adhesion of hot melt adhesive tape according to claim 3, characterized in that, The stirring rate in step (3) is 30-80 rpm and the stirring time is 20-40 min.

6. The method of claim 3, wherein the material is prepared by mixing the tackifier and the wax in a weight ratio of 1:0.1 to 1:0.

5. The heating temperature in step (4) is 120°C.

7. The method for preparing a material for improving the adhesion of hot melt adhesive tape according to claim 3, characterized in that, The stirring rate in step (5) is 60-120 rpm and the stirring time is 5-15 min.

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