Special-shaped titanium alloy capable of enhancing bone regeneration and repair efficacy as well as preparation method and application of special-shaped titanium alloy

By constructing a multi-level porous structure on irregularly shaped titanium alloy implants through vapor phase alloying and dealloying processes, the problem of surface modification of irregularly shaped implants in existing technologies has been solved, thereby improving the bone regeneration and repair efficiency, promoting osteogenic differentiation and bone integration, and reducing the preparation cost.

CN121915286APending Publication Date: 2026-04-24SHANDONG UNIV QILU HOSPITAL
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Patent Information

Application Number
CN202610133268.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-01-30
Publication Date
2026-04-24

AI Technical Summary

Technical Problem

Existing technologies struggle to achieve uniform modification of complex geometries on the surface of irregularly shaped implants, failing to meet the demands of multi-dimensional synergy. Traditional pore-forming techniques are costly and cannot construct multi-level porous structures. Vapor-phase dealloying technology carries the risk of oxidation and nitridation on titanium substrates and lacks cross-scale tissue repair mechanisms.

Method used

A multi-level micro-nano porous structure was constructed on irregularly shaped titanium alloy implants using a synergistic process of vapor phase alloying (VPA) and vapor phase dealloying (VPD). By performing vapor phase alloying and dealloying under low vacuum and high temperature conditions, a coral-like porous structure without oxidation and nitriding was formed.

Benefits of technology

This method achieves uniform modification of irregularly shaped titanium alloy implants across the entire surface, activates the regenerative function of senescent stem cells, promotes osteogenic differentiation and osteointegration, improves bone repair effects, reduces preparation costs, and avoids the complexity of traditional methods.

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Abstract

The invention discloses a special-shaped titanium alloy capable of enhancing bone regeneration and repair efficacy as well as a preparation method and application of the special-shaped titanium alloy. The special-shaped titanium alloy comprises a special-shaped titanium alloy base body and a porous structure attached to the special-shaped titanium alloy base body, and the porous structure is in multi-stage size distribution and comprises long-strip-shaped gullies (100-150 micrometers wide) and large holes (30-50 micrometers wide). And the morphology in the gullies shows coralline ligaments and a nest-shaped pore channel (0.5-2 microns) structure. This can provide space and sites for the growth and adsorption of osteoblasts. According to the method, a gas phase alloying (VPA) and VPD synergistic process is adopted in a breakthrough mode, a non-oxidation / nitridation coralline-shaped hierarchical pore structure is constructed on the surface of the commercial titanium implant, and it can be achieved through verification of an aging animal model that a special-shaped matrix is uniformly modified in the whole domain, the regeneration function of aging stem cells is activated, and the bone repair and regeneration effect is effectively improved.
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