Herbicide as well as preparation method and application thereof

Abstract

The invention relates to the technical field of herbicides, in particular to a herbicide and a preparation method and application thereof.The herbicide is prepared from, by weight, 10%-20% of benzothiazole derivatives, 1%-20% of auxiliary active ingredients, 1%-5% of synergists, 0.1%-30% of accelerants, 30%-70% of carriers and 5%-15% of surface active auxiliaries, and the sum of the mass fraction of all the ingredients is 100%; wherein the benzothiazole derivative is 2-hydroxy-5-methoxyl-N-methylbenzothiazole or an agricultural acceptable salt thereof, and the auxiliary active component comprises one or more of 2, 4-dichlorphenoxyacetic acid, p-nitrobenzaldehyde and acetonyl acetone. According to the herbicide provided by the invention, the benzothiazole derivative is used as a main active component and is matched with the auxiliary active component for use, so that efficient prevention and removal can be realized under the condition of low dosage, and the synergistic synergist and the accelerant are added, so that wetting, permeation and uptake and conduction of the active component on weed leaves are facilitated; the pesticide effect taking speed is increased; the lasting period is prolonged.

Description

Technical Field

[0001] This invention relates to the field of herbicide technology, specifically to a herbicide, its preparation method, and its application. Background Technology

[0002] Weeds compete fiercely with crops for water, nutrients, and light, and are one of the main biological stressors leading to reduced crop yields and quality. Chemical weeding, due to its high efficiency, controllable cost, and wide applicability, has become the most commonly used weed control method in modern agriculture. However, long-term and single-mechanism herbicide use easily induces resistance in weeds, and some formulations still have shortcomings in terms of environmental compatibility, selectivity safety, and application stability. Therefore, there is an urgent need to develop highly efficient and low-toxicity herbicide formulations with novel structures or synergistic effects.

[0003] In the existing technology, benzothiazole compounds have attracted attention in the field of pesticides due to their good biological activity. However, when used alone, they often have problems such as limited spectrum of action, unstable efficacy against specific weeds, or high application dosage. Summary of the Invention

[0004] (a) Purpose of the invention The purpose of this invention is to provide a herbicide, its preparation method, and its application, which enhances the herbicidal effect of benzothiazole derivatives by using auxiliary active ingredients, thereby achieving low dosage and high efficiency.

[0005] (II) Technical Solution To address the above problems, the present invention provides a herbicide comprising, by mass fraction, the following components: The composition comprises 10-20 wt% benzothiazole derivative, 1-20 wt% auxiliary active ingredient, 1-5 wt% synergist, 0.1-30 wt% accelerator, 30-70 wt% carrier, and 5-15 wt% surfactant, with the sum of the mass fractions of all components being 100 wt%. The benzothiazole derivative is 2-hydroxy-5-methoxy-N-methylbenzothiazole or an agriculturally acceptable salt thereof, and the auxiliary active ingredient includes one or more of 2,4-dichlorophenoxyacetic acid, p-nitrobenzaldehyde, and acetone-based acetone.

[0006] In another aspect of the invention, preferably, the agriculturally acceptable salt is a hydrochloride, sulfate, or acetate; and / or, The mass ratio of the benzothiazole derivative to the auxiliary active ingredient is 1:(0.1-1).

[0007] In another aspect of the present invention, preferably, the synergistic agent comprises a cyclic hexapeptide Cyclo (-Gly-Ala-Leu-Val-Pro-Phe) or its acetate; the surfactant comprises one or more of nonionic surfactants, anionic surfactants, and cationic surfactants; wherein the nonionic surfactant is a fatty alcohol polyoxyethylene ether, the anionic surfactant is sodium dodecylbenzenesulfonate, and the cationic surfactant is hexadecyltrimethylammonium bromide; Preferably, the mass fraction of the synergist is 1-2 wt%.

[0008] In another aspect of the present invention, preferably, the accelerator comprises a mixed octanoic acid / decanoic acid ester and polyethylene glycol, wherein the mass ratio of octanoic acid to decanoic acid in the mixed octanoic acid / decanoic acid ester is 1:1, the number average molecular weight of the polyethylene glycol is 300-600, and the mass ratio of the mixed octanoic acid / decanoic acid ester to polyethylene glycol is (3-7):1.

[0009] In another aspect, preferably, a method for preparing a herbicide, the method being applicable to the herbicide described above, the method comprising: S1: Dissolve the benzothiazole derivative in the first part of the carrier to obtain a first solution; S2: Dissolve the auxiliary active ingredient in the second part of the carrier to obtain a second solution; S3: Mix the first solution and the second solution to obtain a third solution; S4: Add the synergist and the promoter to the third solution in sequence to obtain the fourth solution; S5: Add the third part of the carrier and the surfactant to the fourth solution and emulsify to obtain the fifth solution; S6: Adjust the acidity or alkalinity of the fifth solution to a preset pH value to obtain the herbicide.

[0010] In another aspect of the present invention, preferably, step S1 specifically includes: adding the benzothiazole derivative to the first part of the carrier at 20-60°C, stirring at 300-500 rpm for 10-20 min to dissolve, thereby obtaining the first solution, wherein the mass concentration of the benzothiazole derivative in the first solution is 40-80 wt%. Step S2 specifically includes: adding the auxiliary active ingredient to the second part of the carrier at 20-50℃, stirring at 300-500 rpm for 10-15 min to dissolve, and obtaining the second solution, wherein the mass concentration of the auxiliary active ingredient in the second solution is 6-60 wt%.

[0011] In another aspect of the present invention, preferably, step S3 specifically includes: under constant temperature conditions of 25-35°C, slowly adding the second solution dropwise to the first solution at a rate of 1-2 mL / min, while stirring at a rate of 200-600 rpm, and continuing to stir for 10-15 min after the addition is completed to obtain the third solution; Step S4 specifically includes: adding the synergist to the third solution and stirring and dispersing at 400-600 rpm for 5-20 minutes; then adding the promoter and continuing to stir and disperse at 400-600 rpm for 5-20 minutes to obtain the fourth solution.

[0012] In another aspect of the present invention, preferably, step S5 specifically includes: adding the surfactant to the third part of the carrier and stirring at 300-500 rpm for 10-15 min; then, under stirring conditions, adding the fourth solution to the carrier containing the surfactant at a rate of 1-3 mL / min, and performing high-speed shear emulsification treatment with a shear rate of 1000-3000 rpm and an emulsification time of 5-15 minutes, resulting in a system particle size of 1-10 μm after emulsification, thereby obtaining the fifth solution.

[0013] In another aspect of the present invention, preferably, step S6 specifically includes: adding an acidic regulator or an alkaline regulator to adjust the pH of the fifth solution to 5-7; after adjustment, stirring at 300-500 rpm for 10-30 minutes at 25-40°C; and allowing it to stand and cool to 20-25°C to obtain the herbicide. The acidity regulator is hydrochloric acid or acetic acid, and the alkalinity regulator is sodium hydroxide or sodium carbonate.

[0014] In another aspect of the present invention, preferably, is the application of a herbicide as described above, or a herbicide prepared by the method described above, in the control of weeds.

[0015] (III) Beneficial Effects The above-described technical solution of the present invention has the following beneficial technical effects: The herbicide provided by this invention uses 2-hydroxy-5-methoxy-N-methylbenzothiazole or its agriculturally acceptable salt as the main active ingredient. By combining it with one or more of the auxiliary active ingredients 2,4-dichlorophenoxyacetic acid, p-nitrobenzaldehyde, and acetone-based acetone, it can achieve highly efficient control under low dosage conditions. The addition of synergistic and accelerator agents helps the active ingredient wet, penetrate, and systemically translocate on weed leaves, improving the onset speed and prolonging the duration of action. The carrier and surfactant adjuvants ensure good dispersibility and spreading properties of the formulation, improving uniform application in the field while reducing herbicide runoff. Attached Figure Description

[0016] Figure 1 This is an overall flowchart of one embodiment of the present invention. Detailed Implementation

[0017] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to specific embodiments and the accompanying drawings. It should be understood that these descriptions are merely exemplary and not intended to limit the scope of the invention. Furthermore, descriptions of well-known structures and techniques are omitted in the following description to avoid unnecessarily obscuring the concept of the invention.

[0018] Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0019] In the description of this invention, it should be noted that the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0020] Furthermore, the technical features involved in the different embodiments of the present invention described below can be combined with each other as long as they do not conflict with each other.

[0021] Example A herbicide comprising, by mass fraction: The composition comprises 10-20 wt% benzothiazole derivative, 1-20 wt% auxiliary active ingredient, 1-5 wt% synergist, 0.1-30 wt% accelerator, 30-70 wt% carrier, and 5-15 wt% surfactant, with the sum of the mass fractions of all components being 100 wt%. The benzothiazole derivative is 2-hydroxy-5-methoxy-N-methylbenzothiazole or an agriculturally acceptable salt thereof. The methyl group of 2-hydroxy-5-methoxy-N-methylbenzothiazole is substituted only on the nitrogen atom within the benzothiazole ring, and is a monomethyl substitution without polymethyl substitution; the compound has no stereoisomers. By introducing a hydroxyl group at the 2-position, a methoxy group at the 5-position, and a monomethyl substitution on the nitrogen atom within the ring, the electronic distribution characteristics of the parent nucleus structure are altered, achieving a more suitable balance between the compound's polarity and lipophilicity, thereby improving the compound's wettability on plant surfaces and its penetration into plant tissues. The N-methyl monosubstituted structure improves the compound's structural and environmental stability, reduces the degradation rate under light or hydrolysis conditions, and prolongs the duration of action of the active ingredient after application, thus improving herbicidal persistence. Agriculturally acceptable salts are hydrochloride, sulfate, or acetate salts, formed by the acid-base reaction of 2-hydroxy-5-methoxy-N-methylbenzothiazole with corresponding inorganic or organic acids. This formation process does not alter the basic structure of the parent compound; it only improves the ionization degree and water dispersibility of the compound through protonation, thereby improving formulation processability and application stability. Agriculturally acceptable salts exhibit good chemical and storage stability under normal temperature and pressure conditions. They can rapidly dissociate or disperse uniformly in water or conventional agricultural solvent systems, ensuring that the active ingredient can revert to its biologically active molecular form after application, thus maintaining its original herbicidal activity. Benzothiazole derivatives are available in 10-20 wt% concentrations, specifically 11 wt%, 12 wt%, 14 wt%, 16 wt%, 18 wt%, and 19 wt%. Benzothiazole derivatives within these ranges can maintain good formulation dispersibility and application safety while ensuring stable inhibition of target weeds, achieving sustained and effective herbicidal activity at lower application rates, thus balancing efficacy and environmental adaptability.

[0022] The auxiliary active ingredients include one or more of 2,4-dichlorophenoxyacetic acid, p-nitrobenzaldehyde, and acetone-based acetone. 2,4-Dichlorophenoxyacetic acid enhances plant sensitivity to benzothiazole derivatives by interfering with the auxin pathway and cell division process. When used in combination with 2-hydroxy-5-methoxy-N-methylbenzothiazole, it can inhibit broadleaf weeds at low doses. p-nitrobenzaldehyde, by interfering with plant cell metabolism, affecting energy supply and metabolic enzyme activity, enhances the systemic translocation of the compound within the plant when used in combination with 2-hydroxy-5-methoxy-N-methylbenzothiazole, increasing the effective range of action of the active ingredient on the leaves. Acetone-based acetone improves the permeability and transport of the pesticide, increasing the efficiency of benzothiazole derivatives in penetrating the plant cuticle and cell membrane. The auxiliary active ingredient is 1-20 wt%, which can be 3 wt%, 5 wt%, 11 wt%, 13 wt%, 15 wt%, and 17 wt%. The auxiliary active ingredient within the above range can effectively enhance the absorption, translocation, and sensitivity of benzothiazole derivatives in plants, so that the active ingredient can still obtain high biological activity at a low dose, without affecting the stability of the formulation and the safety of crops, thereby improving the overall weeding efficiency.

[0023] Furthermore, in this embodiment, the mass ratio of benzothiazole derivative to auxiliary active ingredient is 1:(0.1-1). Within this ratio range, while ensuring the effect of the active ingredient of benzothiazole derivative, the auxiliary active ingredient can effectively regulate the plant's sensitivity to benzothiazole derivative and promote its absorption and translocation in the plant, thereby obtaining higher herbicidal activity under lower application dosage conditions.

[0024] Furthermore, in this embodiment, the synergistic agent includes the cyclic hexapeptide Cyclo(-Gly-Ala-Leu-Val-Pro-Phe) or its acetate; wherein Gly is glycine, Ala is alanine, Leu is leucine, Val is valine, Pro is proline, and Phe is phenylalanine. The six amino acids form a hexapeptide by closing the loop at both ends in the order of glycine-alanine-leucine-valine-proline-phenylalanine. By restricting the conformational freedom of the molecules, its conformational stability and hydrophobic interaction ability are improved, enabling it to effectively embed into the plant cuticle and interact non-covalently with the cell membrane surface, thereby enhancing the retention and transmembrane transport efficiency of the active ingredients on the plant surface. Furthermore, the mass fraction of the synergist is 1~2wt%, specifically 1wt%, 1.2wt%, 1.5wt%, 1.7wt%, 1.8wt%, and 2wt%. Within the above range, the cyclic hexapeptide can significantly improve the absorption rate and systemic transduction ability of benzothiazole derivatives in plants, while not adversely affecting the stability of the formulation or the safety of crops. Thus, higher herbicidal activity and longer-lasting efficacy can be achieved with reduced application dosage.

[0025] Surfactant adjuvants include one or more of nonionic, anionic, and cationic surfactants; wherein the nonionic surfactant is fatty alcohol polyoxyethylene ether, the anionic surfactant is sodium dodecylbenzenesulfonate, and the cationic surfactant is hexadecyltrimethylammonium bromide; the surfactant adjuvant is 5-15 wt%, and can be 6 wt%, 7 wt%, 9 wt%, 11 wt%, 13 wt%, or 14 wt%; it improves the wettability, spreadability, and adhesion of the formulation, enhances the uniform deposition and retention of active ingredients on the plant surface, and promotes the penetration and absorption of active ingredients into the plant cuticle, while improving the dispersion stability and application stability of the formulation, thereby improving the herbicidal effect and prolonging the duration of efficacy.

[0026] Furthermore, the carrier can be one or more of xylene, ethanol, and N,N-dimethylformamide, and the carrier content is 30-70 wt%, or can be 40 wt%, 50 wt%, 55 wt%, 60 wt%, 65 wt%, or 68 wt% within the above-mentioned content range. The carrier serves as a dispersion and dilution medium to improve the homogeneity and storage stability of the formulation.

[0027] The promoters include a mixture of octanoic acid / decanoic acid and polyethylene glycol (PEG). The mass ratio of octanoic acid to decanoic acid in the octanoic acid / decanoic acid mixture is 1:1. The number average molecular weight of PEG is 300-600. The mass ratio of the octanoic acid / decanoic acid mixture to PEG is (3-7):1. When the octanoic acid / decanoic acid mixture and PEG are combined within the above ratio range, a penetration-promoting system with a suitable hydrophilicity-hydrophobicity balance is formed. This system can improve the wetting and spreading ability of the active ingredients on the plant surface and enhance their swelling effect on the plant cuticle, thereby promoting the absorption of benzothiazole derivatives. It facilitates penetration and translocation into plant tissues, while simultaneously improving the compatibility and dispersion stability of the formulation; the promoter ranges from 0.1-30 wt%, and can be 0.3 wt%, 0.6 wt%, 0.9 wt%, 1.3 wt%, 1.7 wt%, 2 wt%, 5 wt%, 10 wt%, 15 wt%, 20 wt%, 25 wt%, or 28 wt%; within the above content range, the promoter can significantly improve the absorption efficiency and bioavailability of the active ingredient without adversely affecting the stability of the formulation or the safety of crops.

[0028] The herbicide provided in this embodiment uses 2-hydroxy-5-methoxy-N-methylbenzothiazole or its agriculturally acceptable salt as the main active ingredient. By combining it with one or more of the auxiliary active ingredients 2,4-dichlorophenoxyacetic acid, p-nitrobenzaldehyde, and acetone-based acetone, it can achieve highly efficient control under low dosage conditions. The addition of synergistic and accelerator agents helps the active ingredient wet, penetrate, and systemically translocate on weed leaves, improving the onset speed and prolonging the duration of action. The carrier and surfactant adjuvants ensure good dispersibility and spreading properties of the formulation, improving uniform application in the field while reducing herbicide runoff.

[0029] Furthermore, this embodiment also provides a method for preparing a herbicide. Figure 1 An overall flowchart of one embodiment of the present invention is shown, as follows: Figure 1 As shown, the preparation method is applicable to the herbicides mentioned above, and the preparation method includes: S1: Dissolve the benzothiazole derivative in the first part of the support to obtain a first solution; the support includes a first part, a second part and a third part, and the ratio of the first part, the second part and the third part is (2-4):(2-4):(4-6). The dissolution includes: adding the benzothiazole derivative to the first part of the support at 20-60℃ and stirring at 300-500 rpm for 10-20 min to obtain the first solution, and the mass concentration of the benzothiazole derivative in the first solution is 40-80 wt%; during the dissolution process, the system is kept closed or protected by an inert gas to reduce oxidation and loss of volatile solvents, and the viscosity of the system is stabilized by constant temperature control, thereby improving the uniformity of dissolution and the stability of the components.

[0030] S2: Dissolve the auxiliary active ingredient in the second part of the carrier to obtain a second solution, including: adding the auxiliary active ingredient to the second part of the carrier at 20-50℃, stirring at 300-500 rpm for 10-15 min to obtain a second solution, wherein the mass concentration of the auxiliary active ingredient in the second solution is 6-60 wt%.

[0031] S3: Mix the first solution and the second solution to obtain the third solution, including: under constant temperature conditions of 25-35℃, slowly add the second solution dropwise to the first solution at a rate of 1-2 mL / min, while stirring at a speed of 200-600 rpm. After the addition is completed, continue stirring for 10-15 min to obtain the third solution. By slowly adding the solution and stirring continuously, precipitation or phase separation caused by local concentration abrupt changes can be avoided, thereby improving the uniformity of the system.

[0032] S4: Add the synergist and the accelerator to the third solution in sequence to obtain the fourth solution, including: adding the synergist to the third solution and stirring and dispersing at 400-600 rpm for 5-20 minutes; then adding the accelerator and continuing to stir and disperse at 400-600 rpm for 5-20 minutes to obtain the fourth solution, thereby promoting the formation of a stable dispersion system of each functional component through moderate shearing.

[0033] S5: Add the third part of the carrier and the surfactant to the fourth solution for emulsification to obtain the fifth solution, including: adding the surfactant to the third part of the carrier and stirring at 300-500 rpm for 10-15 min; then, under stirring conditions, adding the fourth solution to the carrier containing the surfactant at a rate of 1-3 mL / min, and performing high-speed shear emulsification treatment with a shear rate of 1000-3000 rpm and an emulsification time of 5-15 min. The particle size of the emulsified system is 1-10 μm, thus obtaining the fifth solution. By controlling the shear rate and emulsification time, the system forms a stable emulsion structure with uniform particle size distribution.

[0034] S6: Adjust the pH of the fifth solution to the preset pH value to obtain the herbicide, including: adding an acid regulator or an alkaline regulator to adjust the pH of the fifth solution to 5-7, stirring at 300-500 rpm for 10-30 minutes at 25-40℃, and letting it stand and cool to 20-25℃ to obtain the herbicide; The acidity regulator is hydrochloric acid or acetic acid, and the alkalinity regulator is sodium hydroxide or sodium carbonate. After pH adjustment, the system exhibits good chemical stability, dispersion stability, and storage stability.

[0035] This embodiment also provides the application of the above-mentioned herbicide, or the herbicide prepared by the above-mentioned herbicide preparation method, in the control of weeds.

[0036] Example 1 A herbicide, by mass fraction, comprises the following components: a benzothiazole derivative: 2-hydroxy-5-methoxy-N-methylbenzothiazole at 16 wt%; an auxiliary active ingredient: 2,4-dichlorophenoxyacetic acid at 10 wt%; a synergist: cyclic hexapeptide acetate at 1.5 wt%; an accelerator: a mixed octanoic acid / capric acid ester at 9 wt%; polyethylene glycol with a number average molecular weight of 400 at 2 wt%; a surfactant: fatty alcohol polyoxyethylene ether at 10 wt%; and a carrier: xylene at 51.5 wt%.

[0037] Preparation methods include: S1: Dissolve 2-hydroxy-5-methoxy-N-methylbenzothiazole in a first portion of xylene to obtain a first solution; the first portion of xylene is 12.5 wt%, and the dissolution includes: adding 2-hydroxy-5-methoxy-N-methylbenzothiazole to the first portion of xylene at 40°C, stirring at 400 rpm for 15 min to dissolve, and obtaining the first solution, wherein the mass concentration of 2-hydroxy-5-methoxy-N-methylbenzothiazole in the first solution is 56 wt%.

[0038] S2: Dissolve 2,4-dichlorophenoxyacetic acid in a second portion of xylene to obtain a second solution, comprising: adding 2,4-dichlorophenoxyacetic acid to a second portion of xylene at 35°C, wherein the second portion of xylene is 12.5 wt%, stirring at 400 rpm for 12 min to obtain a second solution, wherein the mass concentration of 2,4-dichlorophenoxyacetic acid in the second solution is 44 wt%.

[0039] S3: Mix the first solution and the second solution to obtain the third solution, including: under constant temperature of 30℃, slowly add the second solution dropwise to the first solution at a rate of 1.5 mL / min while stirring at a rate of 400 rpm. After the addition is completed, continue stirring for 12 min to obtain the third solution.

[0040] S4: Add cyclic hexapeptide acetate, octanoic acid / decanoic acid mixed ester and polyethylene glycol sequentially to the third solution to obtain the fourth solution, including: adding cyclic hexapeptide acetate to the third solution and stirring and dispersing at 500 rpm for 15 minutes; then adding octanoic acid / decanoic acid mixed ester and polyethylene glycol, and continuing to stir and disperse at 500 rpm for 15 minutes to obtain the fourth solution.

[0041] S5: Add the third part of xylene and fatty alcohol polyoxyethylene ether to the fourth solution for emulsification to obtain the fifth solution, including: adding fatty alcohol polyoxyethylene ether to the third part of xylene, the third part of xylene being 26.5 wt%, stirring at 400 rpm for 12 min; then, under stirring conditions, adding the fourth solution to a carrier containing surfactants at a rate of 2 mL / min, and performing high-speed shear emulsification treatment, with a shear rate of 2000 rpm and an emulsification time of 10 min. The particle size of the emulsified system is 1-10 μm, thus obtaining the fifth solution. By controlling the shear rate and emulsification time, a stable emulsion structure with uniform particle size distribution is formed in the system.

[0042] S6: Adjust the pH of the fifth solution to the preset pH value to obtain the herbicide, including: adding hydrochloric acid to adjust the pH of the fifth solution to 6, stirring at 400 rpm for 20 minutes at 30°C after adjustment, and allowing it to stand and cool to 22°C to obtain the herbicide.

[0043] Example 2 A herbicide, by mass fraction, comprises the following components: benzothiazole derivative: 20 wt% of hydrochloride of 2-hydroxy-5-methoxy-N-methylbenzothiazole; auxiliary active ingredient: 20 wt% of p-nitrobenzaldehyde; synergist: 5 wt% of cyclic hexapeptide; accelerator: 3 wt% of octanoic acid / capric acid mixed ester; polyethylene glycol with a number average molecular weight of 600 and a mass fraction of 1 wt%; surfactant: 5 wt% of sodium dodecylbenzenesulfonate; and carrier: 46 wt% of ethanol.

[0044] Preparation methods include: S1: Dissolve the hydrochloride of 2-hydroxy-5-methoxy-N-methylbenzothiazole in the first part of xylene to obtain a first solution; the first part of ethanol is 10 wt%, and the dissolution includes: adding the hydrochloride of 2-hydroxy-5-methoxy-N-methylbenzothiazole to the first part of ethanol at 20°C, stirring at 300 rpm for 10 min to dissolve, and obtaining the first solution, wherein the mass concentration of the hydrochloride of 2-hydroxy-5-methoxy-N-methylbenzothiazole in the first solution is 67 wt%.

[0045] S2: Dissolve p-nitrobenzaldehyde in a second portion of ethanol to obtain a second solution, comprising: adding p-nitrobenzaldehyde to a second portion of ethanol at 20°C, the second portion of ethanol being 15 wt%, stirring at 300 rpm for 10 min to dissolve, thereby obtaining a second solution, wherein the mass concentration of 2,4-dichlorophenoxyacetic acid in the second solution is 57 wt%.

[0046] S3: Mix the first solution and the second solution to obtain the third solution, including: under constant temperature of 25℃, slowly add the second solution dropwise to the first solution at a rate of 1 mL / min while stirring at a rate of 200 rpm. After the addition is completed, continue stirring for 10 min to obtain the third solution.

[0047] S4: Add cyclic hexapeptide, octanoic acid / decanoic acid mixed ester and polyethylene glycol sequentially to the third solution to obtain the fourth solution, including: adding cyclic hexapeptide to the third solution and stirring and dispersing at 400 rpm for 5 minutes; then adding octanoic acid / decanoic acid mixed ester and polyethylene glycol, and continuing to stir and disperse at 400 rpm for 5 minutes to obtain the fourth solution.

[0048] S5: Emulsify the fourth solution by adding the third part of ethanol and sodium dodecylbenzenesulfonate to obtain the fifth solution, including: adding sodium dodecylbenzenesulfonate to the third part of ethanol (21 wt%) and stirring at 300 rpm for 10 min; then, under stirring conditions, adding the fourth solution to a carrier containing a surfactant at a rate of 1 mL / min and performing high-speed shear emulsification at 1000 rpm for 5 min. The particle size of the emulsified system is 1-10 μm, thus obtaining the fifth solution. By controlling the shear rate and emulsification time, a stable emulsion structure with uniform particle size distribution is formed in the system.

[0049] S6: Adjust the pH of the fifth solution to the preset pH value to obtain the herbicide, including: adding acetic acid to adjust the pH of the fifth solution to 5, stirring at 300 rpm for 10 minutes at 25°C after adjustment, and allowing it to stand and cool to 20°C to obtain the herbicide.

[0050] Example 3 A herbicide, by mass fraction, comprises the following components: benzothiazole derivative: 10 wt% acetate of 2-hydroxy-5-methoxy-N-methylbenzothiazole; auxiliary active ingredient: 1 wt% acetone; synergist: 2 wt% cyclic hexapeptide; promoter: 5 wt% octanoic acid / capric acid mixed ester; polyethylene glycol with a number average molecular weight of 600 and a mass fraction of 1 wt%; surfactant: 6 wt% hexadecyltrimethylammonium bromide; and carrier: 75 wt% N,N-dimethylformamide.

[0051] Preparation methods include: S1: Dissolve the acetate of 2-hydroxy-5-methoxy-N-methylbenzothiazole in the first part of N,N-dimethylformamide to obtain a first solution; the first part of N,N-dimethylformamide is 15 wt%, and the dissolution includes: adding the acetate of 2-hydroxy-5-methoxy-N-methylbenzothiazole to the first part of N,N-dimethylformamide at 60°C, stirring at 500 rpm for 20 min to dissolve, and obtaining the first solution, wherein the mass concentration of the acetate of 2-hydroxy-5-methoxy-N-methylbenzothiazole in the first solution is 40 wt%.

[0052] S2: Dissolve acetone in the second part of N,N-dimethylformamide to obtain a second solution, comprising: adding acetone to the second part of N,N-dimethylformamide at 50°C, wherein the second part of N,N-dimethylformamide is 15 wt%, stirring at 500 rpm for 15 min to obtain a second solution, wherein the mass concentration of acetone in the second solution is 6.25 wt%.

[0053] S3: Mix the first solution and the second solution to obtain the third solution, including: slowly adding the second solution dropwise to the first solution at a rate of 2 mL / min under a constant temperature of 35℃, while stirring at a speed of 600 rpm. After the addition is completed, continue stirring for 15 min to obtain the third solution.

[0054] S4: Add cyclic hexapeptide, octanoic acid / decanoic acid mixed ester and polyethylene glycol sequentially to the third solution to obtain the fourth solution, including: adding cyclic hexapeptide to the third solution and stirring and dispersing at 600 rpm for 20 minutes; then adding octanoic acid / decanoic acid mixed ester and polyethylene glycol, and continuing to stir and disperse at 600 rpm for 20 minutes to obtain the fourth solution.

[0055] S5: Add the third part of N,N-dimethylformamide and hexadecyltrimethylammonium bromide to the fourth solution for emulsification to obtain the fifth solution, including: adding hexadecyltrimethylammonium bromide to the third part of N,N-dimethylformamide, where the third part of N,N-dimethylformamide is 45wt%, and stirring at 500 rpm for 15 min; then, under stirring conditions, adding the fourth solution to a carrier containing a surfactant at a rate of 3 mL / min, and performing high-speed shear emulsification treatment at a shear rate of 3000 rpm for 15 min. The particle size of the emulsified system is 1-10 μm, thus obtaining the fifth solution. By controlling the shear rate and emulsification time, a stable emulsion structure with uniform particle size distribution is formed in the system.

[0056] S6: Adjust the pH of the fifth solution to the preset pH value to obtain the herbicide, including: adding sodium hydroxide to adjust the pH of the fifth solution to 7, stirring at 500 rpm for 30 minutes at 40°C, and allowing it to stand and cool to 25°C to obtain the herbicide.

[0057] Comparative Example 1 It contains no auxiliary active ingredients, has a carrier of 61.5 wt%, and the remaining composition is the same as in Example 1.

[0058] Comparative Example 2 It contains no synergist, has a carrier of 53 wt%, and the remaining composition is the same as in Example 1.

[0059] Comparative Example 3 It contains no accelerator, has a carrier of 62.5 wt%, and the remaining composition is the same as in Example 1.

[0060] Comparative Example 4 It does not contain auxiliary active ingredients, synergists and promoters, carrier: 74 wt%, and the rest of the composition is the same as in Example 1.

[0061] The herbicidal activity was evaluated using a greenhouse pot method. Crataegus pinnatifida, Amaranthus retroflexus, and Setaria viridis were selected as test weeds. Weed seeds were sown in 12 cm diameter plastic pots, with approximately 10 uniformly growing seedlings per pot. These were cultured in a greenhouse at 25±2℃ and 60–75% relative humidity until the 3–5 leaf stage. The herbicides prepared in Examples 1-3 and Comparative Examples 1-4 were formulated to the same concentration based on the active ingredient and applied as a uniform foliar spray at a rate of 150 g a.i. / ha and a spray volume of 450 L / ha. Each treatment was replicated in triplicate, with a blank control group (no herbicide application). After application, the weeds were cultured under the same greenhouse conditions for 21 days. The fresh weight of the topsoil of each treatment was measured and compared with the blank control group to calculate the control efficacy. Control efficacy (%) was calculated using the following formula: Control efficacy (%) = (Fresh weight of blank control group - Fresh weight of treatment group) / Fresh weight of blank control group × 100%.

[0062] Table 1 shows the weed control effects of Examples 1-3 and Comparative Examples 1-4: Table 1. Weed control efficacy of Examples 1-3 and Comparative Examples 1-4 As shown in Table 1, the herbicides prepared in Examples 1-3 all showed significant inhibitory effects on the tested weeds, which were superior to the weed control effects of Comparative Examples 1-4.

[0063] It should be understood that the specific embodiments described above are merely illustrative or explanatory of the principles of the invention and do not constitute a limitation thereof. Therefore, any modifications, equivalent substitutions, improvements, etc., made without departing from the spirit and scope of the invention should be included within the protection scope of the invention. Furthermore, the appended claims are intended to cover all variations and modifications falling within the scope and boundaries of the appended claims, or equivalent forms of such scope and boundaries.

[0064] The present invention has been described above with reference to embodiments thereof. However, these embodiments are merely illustrative and not intended to limit the scope of the invention. The scope of the invention is defined by the appended claims and their equivalents. Various substitutions and modifications can be made by those skilled in the art without departing from the scope of the invention, and all such substitutions and modifications should fall within the scope of the invention.

[0065] Although embodiments of the present invention have been described in detail, it should be understood that various changes, substitutions, and modifications can be made to the embodiments of the present invention without departing from the spirit and scope of the invention.

[0066] Obviously, the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the scope of protection of this invention.

Claims

1. A herbicide, characterized in that, The herbicide comprises the following components by mass fraction: The composition comprises 10-20 wt% benzothiazole derivative, 1-20 wt% auxiliary active ingredient, 1-5 wt% synergist, 0.1-30 wt% accelerator, 30-70 wt% carrier, and 5-15 wt% surfactant, with the sum of the mass fractions of all components being 100 wt%. The benzothiazole derivative is 2-hydroxy-5-methoxy-N-methylbenzothiazole or an agriculturally acceptable salt thereof, and the auxiliary active ingredient includes one or more of 2,4-dichlorophenoxyacetic acid, p-nitrobenzaldehyde, and acetone-based acetone.

2. The herbicide according to claim 1, characterized in that, The agriculturally acceptable salts are hydrochlorides, sulfates, or acetates; and / or, The mass ratio of the benzothiazole derivative to the auxiliary active ingredient is 1:(0.1-1).

3. The herbicide according to claim 1, characterized in that, The synergistic agent includes cyclic hexapeptide Cyclo (-Gly-Ala-Leu-Val-Pro-Phe) or its acetate; the surfactant includes one or more of nonionic surfactants, anionic surfactants, and cationic surfactants; wherein the nonionic surfactant is fatty alcohol polyoxyethylene ether, the anionic surfactant is sodium dodecylbenzenesulfonate, and the cationic surfactant is hexadecyltrimethylammonium bromide; Preferably, the mass fraction of the synergist is 1-2 wt%.

4. The herbicide according to claim 1, characterized in that, The accelerator comprises a mixed octanoic acid / decanoic acid ester and polyethylene glycol, wherein the mass ratio of octanoic acid to decanoic acid in the mixed octanoic acid / decanoic acid ester is 1:1, the number average molecular weight of the polyethylene glycol is 300-600, and the mass ratio of the mixed octanoic acid / decanoic acid ester to polyethylene glycol is (3-7):

1.

5. A method for preparing a herbicide, characterized in that, The preparation method is applicable to the herbicide according to any one of claims 1-4, and the preparation method includes: S1: Dissolve the benzothiazole derivative in the first part of the carrier to obtain a first solution; S2: Dissolve the auxiliary active ingredient in the second part of the carrier to obtain a second solution; S3: Mix the first solution and the second solution to obtain a third solution; S4: Add the synergist and the promoter to the third solution in sequence to obtain the fourth solution; S5: Add the third part of the carrier and the surfactant to the fourth solution and emulsify to obtain the fifth solution; S6: Adjust the acidity or alkalinity of the fifth solution to a preset pH value to obtain the herbicide.

6. The method for preparing the herbicide according to claim 5, characterized in that: Step S1 specifically includes: adding the benzothiazole derivative to the first part of the carrier at 20-60℃, stirring at 300-500 rpm for 10-20 min to dissolve, and obtaining the first solution, wherein the mass concentration of the benzothiazole derivative in the first solution is 40-80 wt%. Step S2 specifically includes: adding the auxiliary active ingredient to the second part of the carrier at 20-50℃, stirring at 300-500 rpm for 10-15 min to dissolve, and obtaining the second solution, wherein the mass concentration of the auxiliary active ingredient in the second solution is 6-60 wt%.

7. The method for preparing the herbicide according to claim 5, characterized in that: Step S3 specifically includes: under constant temperature conditions of 25-35℃, slowly adding the second solution dropwise to the first solution at a rate of 1-2 mL / min, while stirring at a rate of 200-600 rpm, and continuing to stir for 10-15 min after the addition is completed to obtain the third solution; Step S4 specifically includes: adding the synergist to the third solution and stirring and dispersing at 400-600 rpm for 5-20 minutes; then adding the promoter and continuing to stir and disperse at 400-600 rpm for 5-20 minutes to obtain the fourth solution.

8. The method for preparing the herbicide according to claim 5, characterized in that: Step S5 specifically includes: adding the surfactant to the third part of the carrier and stirring at 300-500 rpm for 10-15 min; then, under stirring conditions, adding the fourth solution to the carrier containing the surfactant at a rate of 1-3 mL / min, and performing high-speed shear emulsification treatment with a shear rate of 1000-3000 rpm and an emulsification time of 5-15 minutes, resulting in a system particle size of 1-10 μm after emulsification, to obtain the fifth solution.

9. The method for preparing the herbicide according to claim 5, characterized in that: Step S6 specifically includes: adding an acidic or alkaline regulator to adjust the pH of the fifth solution to 5-7; after adjustment, stirring at 300-500 rpm for 10-30 minutes at 25-40℃; and allowing it to stand and cool to 20-25℃ to obtain the herbicide. The acidity regulator is hydrochloric acid or acetic acid, and the alkalinity regulator is sodium hydroxide or sodium carbonate.

10. The application of a herbicide according to any one of claims 1-4, or a herbicide prepared by the preparation method of any one of claims 5-9, in the control of weeds.

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