Intelligent switching control method and system for multi-way valve in radionuclide separation

Abstract

The invention relates to the technical field of radioactive separation control, and discloses an intelligent switching control method and system for a multi-way valve in radionuclide separation, and the method comprises the steps: 1, pushing inert liquid, calibrating the dead volume of a liquid outlet section, and determining the quantitative line cleaning volume and the pre-charging volume of a target channel; step 2, advancing the pre-wetting liquid according to a preset pre-wetting volume and a pre-filling volume of a target channel; 3, pushing the feed liquid according to the loading volume, and executing a safe flushing volume according to a pressure signal; 4, purging the first leacheate and the second leacheate according to the quantitative line cleaning volume; 5, collecting an activity signal to generate an activity window entering signal and an activity window exiting signal; 6, responding to the signal, and switching to a target collection channel according to the isolation section volume, the quantitative line cleaning volume and the target channel pre-charging volume; and 7, cleaning and purging are conducted, the default safety position is reset, and the accumulated propelling volume of the pump is recorded. According to the invention, quantitative and sequential management of flow path switching in the radionuclide separation process is realized.

Description

Technical Field

[0001] This invention belongs to the field of radioactive separation control technology, specifically relating to an intelligent switching control method and system for multi-way valves in radionuclide separation. Background Technology

[0002] Radionuclide separation technology is widely used in nuclear chemistry research, radiopharmaceutical preparation, and related nuclear technology fields. In such processes, separation steps such as adsorption, rinsing, and elution are typically used to separate the target radionuclide from impurity components on a stationary phase medium. The separation process involves multiple liquid media passing sequentially through a separation column or adsorbent material, switching different flow paths at different stages to complete operations such as sample loading, rinsing, elution, and cleaning.

[0003] In existing technologies, multi-port valves are typically used to switch flow paths between different liquid sources and different output channels. Switching in multi-port valves is mostly achieved through preset time control or manual intervention, lacking a volume reference and signal determination mechanism that matches the actual fluid conditions. During actual operation, due to factors such as dead volume, residual liquid, and pressure fluctuations in the flow path, relying solely on time control or empirical parameters can easily lead to fluid mixing between different stages, affecting the separation purity of the target radionuclide. Furthermore, in identifying the elution zone, if a stable determination is not made in conjunction with activity signals, the switching of the target collection channel may occur prematurely or delayed, reducing separation efficiency. In addition, the radionuclide separation process has high requirements for flow path safety. When abnormal pressure or valve misalignment occurs, failure to take timely measures may result in damage to the separation column or contamination of the flow path. Summary of the Invention

[0004] This invention provides an intelligent switching control method and system for multi-way valves in radionuclide separation, which solves the technical problems in related technologies where the switching process of multi-way valves relies on fixed time or empirical parameters for control, lacks a judgment mechanism based on the actual volume and activity state of the flow path, resulting in difficulty in eliminating flow path residues, high risk of fluid mixing between stages, and inaccurate timing of target collection channel switching.

[0005] This invention provides an intelligent switching control method for multi-port valves in radionuclide separation, comprising the following steps: Step 1: Switch the outlet multi-way valve to the waste liquid channel and the inlet multi-way valve to the inert liquid channel. Control the pump to push inert liquid and record the dead volume of the outlet section. Determine the quantitative cleaning volume and the pre-filling volume of the target channel. Step 2: Switch the inlet multi-way valve to the pre-wetting liquid channel, keep the outlet multi-way valve in the waste liquid channel, control the pump to advance according to the preset pre-wetting volume, and advance according to the target channel pre-fill volume; Step 3: Switch the inlet multi-way valve to the feed liquid channel and the outlet multi-way valve to the waste liquid channel. Control the pump to advance according to the sample loading volume and execute the safety flushing volume according to the pressure signal. Step 4: Switch the inlet multi-port valve to the first rinsing liquid channel and the second rinsing liquid channel in sequence, and advance according to volume. Open the air source purging valve and perform purging according to the quantitative cleaning volume. Step 5: Switch the inlet multi-way valve to the target eluent channel and the outlet multi-way valve to keep the waste liquid channel. Collect the activity signal, calculate the smoothed activity signal, and generate the activity window entry signal and activity window exit signal. Step 6: In response to the activity window entry signal or activity window exit signal, the three-stage zero-residue switching unit is invoked, and the isolation section volume, quantitative cleaning volume, and target channel pre-filling volume are executed sequentially and switched to the target collection channel. Step 7: After elution is complete, switch the inlet multi-way valve to the cleaning fluid channel and the outlet multi-way valve to the waste fluid channel. Advance according to the cleaning volume and purge according to the quantitative cleaning volume. Reset to the default safe position and record the cumulative advance volume of the pump.

[0006] This invention also provides an intelligent switching control system for multi-port valves in radionuclide separation, comprising: The dead volume determination module is used to switch the outlet multi-way valve to the waste liquid channel and the inlet multi-way valve to the inert liquid channel, control the pump to push inert liquid and record the dead volume of the outlet section, and determine the quantitative cleaning volume and the pre-fill volume of the target channel. The pre-wetting and pre-filling module is used to switch the inlet multi-way valve to the pre-wetting liquid channel, keep the outlet multi-way valve in the waste liquid channel, control the pump to advance according to the preset pre-wetting volume, and advance according to the target channel pre-filling volume; The sample loading safety control module is used to switch the inlet multi-way valve to the liquid channel, keep the outlet multi-way valve in the waste channel, control the pump to advance according to the sample loading volume, and execute the safety flushing volume according to the pressure signal; The segmented rinsing and cleaning module is used to sequentially switch the inlet multi-way valve to the first rinsing liquid channel and the second rinsing liquid channel, and advance by volume, open the air source purging valve and perform purging according to the quantitative cleaning volume; The activity window determination module is used to switch the inlet multi-way valve to the target eluent channel and the outlet multi-way valve to maintain the waste liquid channel, collect the activity signal, calculate the smoothed activity signal, and generate the activity window entry signal and the activity window exit signal. The zero-residue switching module is used to respond to the activity window entry signal or the activity window exit signal to call the three-stage zero-residue switching unit, and execute and switch to the target collection channel in sequence according to the isolation section volume, quantitative cleaning volume, and target channel pre-filling volume; The termination cleaning reset module is used to switch the inlet multi-way valve to the cleaning fluid channel and the outlet multi-way valve to the waste fluid channel after elution. It advances according to the cleaning volume and purges according to the quantitative cleaning volume, resets to the default safety position, and records the cumulative volume advanced by the pump.

[0007] The beneficial effects of this invention are as follows: By establishing a volume parameter system based on the dead volume of the effluent section, this invention integrates key control quantities such as the quantitative clearing volume and the target channel pre-filling volume into a unified volume measurement framework, achieving quantitative control of the multi-port valve switching process. Fluid propulsion at each stage is measured based on the cumulative pump propulsion volume and is linked with valve position signals, pressure signals, and activity signals, ensuring clear judgment conditions and execution sequences for flow path switching. By setting rules for generating activity window entry and exit signals, and in conjunction with a three-stage zero-residue switching structure, the risk of fluid contamination between different stages is effectively reduced, improving the clarity of the target nuclide collection zone boundaries. Simultaneously, a safety flushing volume is executed under abnormal pressure conditions, and cleaning and reset operations are performed after the process is completed, maintaining stable system operation. Overall, this improves the repeatability and consistency of multi-port valve switching control during radionuclide separation. Attached Figure Description

[0008] Figure 1 This is a flowchart of the intelligent switching control method for multi-port valves in the separation of radionuclides according to the present invention. Detailed Implementation

[0009] The subject matter described herein will now be discussed with reference to exemplary embodiments. It should be understood that these embodiments are discussed only to enable those skilled in the art to better understand and implement the subject matter described herein, and changes may be made to the function and arrangement of the elements discussed without departing from the scope of this specification. Various processes or components may be omitted, substituted, or added as needed in the examples. Furthermore, features described in some examples may be combined in other examples.

[0010] It should be noted that, unless otherwise defined, the technical or scientific terms used in one or more embodiments of the present invention should have the ordinary meaning understood by one of ordinary skill in the art to which this invention pertains. The terms "first," "second," and similar terms used in one or more embodiments of the present invention do not indicate any order, quantity, or importance, but are merely used to distinguish different components. Terms such as "comprising" or "including" mean that the element or object preceding the word encompasses the elements or objects listed after the word and their equivalents, without excluding other elements or objects. Terms such as "connected" or "linked" are not limited to physical or mechanical connections, but can include electrical connections, whether direct or indirect. Terms such as "upper," "lower," "left," and "right" are used only to indicate relative positional relationships; when the absolute position of the described object changes, the relative positional relationship may also change accordingly.

[0011] like Figure 1 As shown, the intelligent switching control method for multi-port valves in radionuclide separation includes the following steps: Step 1: Switch the outlet multi-way valve to the waste liquid channel and the inlet multi-way valve to the inert liquid channel. Control the pump to push inert liquid and record the dead volume of the outlet section. Determine the quantitative cleaning volume and the pre-filling volume of the target channel. Step 2: Switch the inlet multi-way valve to the pre-wetting liquid channel, keep the outlet multi-way valve in the waste liquid channel, control the pump to advance according to the preset pre-wetting volume, and advance according to the target channel pre-fill volume; Step 3: Switch the inlet multi-way valve to the feed liquid channel and the outlet multi-way valve to the waste liquid channel. Control the pump to advance according to the sample loading volume and execute the safety flushing volume according to the pressure signal. Step 4: Switch the inlet multi-port valve to the first rinsing liquid channel and the second rinsing liquid channel in sequence, and advance according to volume. Open the air source purging valve and perform purging according to the quantitative cleaning volume. Step 5: Switch the inlet multi-way valve to the target eluent channel and the outlet multi-way valve to keep the waste liquid channel. Collect the activity signal, calculate the smoothed activity signal, and generate the activity window entry signal and activity window exit signal. Step 6: In response to the activity window entry signal or activity window exit signal, the three-stage zero-residue switching unit is invoked, and the isolation section volume, quantitative cleaning volume, and target channel pre-filling volume are executed sequentially and switched to the target collection channel. Step 7: After elution is complete, switch the inlet multi-way valve to the cleaning fluid channel and the outlet multi-way valve to the waste fluid channel. Advance according to the cleaning volume and purge according to the quantitative cleaning volume. Reset to the default safe position and record the cumulative advance volume of the pump.

[0012] In one embodiment of the present invention, the radionuclide separation refers to a process in which a target radionuclide is separated and collected from a mixed system through separation operations such as adsorption, rinsing, and elution during the preparation of nuclear chemistry or radiopharmaceuticals. This type of separation process typically involves multiple liquid media sequentially passing through a stationary phase separation medium, switching different fluid channels at different stages, such as sample loading, rinsing, elution, and cleaning. A multi-port valve is a valve assembly with multiple fluid channel interfaces, used to establish switchable flow path connections between different liquid sources and different discharge or collection channels. In this invention, the multi-port valve is respectively located on the inlet and outlet sides of the flow path. By changing the position of the valve core, the flow path switching between different media such as inert liquid, feed liquid, rinsing liquid, target elution liquid, and cleaning liquid, as well as the switching between different output channels such as waste liquid channel and target collection channel, can be achieved. The switching state of the multi-port valve directly determines the flow path of the fluid in the separation system; therefore, its switching sequence and switching conditions have a crucial impact on the separation results.

[0013] In one embodiment of the present invention, in order to achieve volume benchmark calibration before switching of multi-port valves in the radionuclide separation process, the dead volume of the outlet section is first determined, and the target channel pre-fill volume and quantitative cleaning volume are derived based on this. The specific process includes: Step 11: Switch the outlet multi-way valve to the waste liquid channel and maintain it, and switch the inlet multi-way valve to the inert liquid channel and maintain it. The waste liquid channel is used to discharge non-target products or flushing fluid, and the inert liquid channel is connected to an inert liquid source. The inert liquid is a liquid that does not participate in the separation reaction and does not contain the target radioactive nuclide. Then, read the valve position signal. When the valve position signal indicates that both the outlet and inlet multi-way valves are in the correct position in their respective channels, determine the initial reading of the pump's cumulative propulsion volume as the starting point for volumetric propulsion measurement. The cumulative propulsion volume is the cumulative measurement reading of the pump in volumetric propulsion mode, used to represent the actual volume of fluid propelled. From this measurement starting point, maintain the valve position signal until the dead volume recording of the outlet section is completed to ensure the flow path structure remains stable and avoid measurement errors.

[0014] Step 12: Under the aforementioned valve position holding conditions, the control pump continuously pushes inert liquid while simultaneously acquiring activity signals. The activity signal is acquired by an activity probe installed at the end of the outlet section, reflecting the activity level of radionuclides in the outflowing liquid. The activity probe baseline refers to the reference value of the activity signal measured under conditions without radionuclides. The difference between the activity signal and the activity probe baseline yields the activity deviation signal. When the activity deviation signal is not less than a preset threshold and persists for a preset duration, a criterion event is triggered. This criterion event indicates that the residual fluid in the original flow path has been completely replaced by inert liquid to the detection position. At this time, the cumulative pumping volume is read and recorded as the dead volume of the outlet section. The dead volume of the outlet section refers to the effective volume contained within the flow path from the pump outlet to the current channel outlet of the outlet multi-way valve under the current valve position combination state. The fluid in this volume will not reach the actual discharge end or collection end before complete replacement. By determining the difference between the activity signal and the activity probe baseline, the dead volume boundary can be determined without relying on empirical estimation.

[0015] Step 13: After obtaining the dead volume of the outlet section, this dead volume is determined as the pre-fill volume of the target channel. The pre-fill volume of the target channel refers to the volume that needs to be pre-filled to ensure the purity of the fluid in the target channel before switching the outlet multi-way valve to the target collection channel. Further, the pre-stored quantitative clearing multiple is multiplied by the dead volume of the outlet section to obtain the quantitative clearing volume. The quantitative clearing multiple is a fixed integer that remains unchanged in the same radionuclide separation process; the quantitative clearing volume refers to the volume parameter used to completely remove the residue from the previous flow path during the multi-way valve switching process.

[0016] Through the above steps, a volumetric parameter system centered on the dead volume of the effluent section is formed, ensuring that the pre-fill volume of the target channel and the quantitative cleaning volume both originate from the same measured baseline. This volumetric parameter system provides a unified metering caliber during radionuclide separation, enabling sequential connection of the isolation section, cleaning section, and pre-fill section in intelligent switching control of multi-port valves, avoiding cross-contamination and residual mixing between different flow paths. By combining activity signal triggering with volume measurement, deterministic volume control matching the actual flow path structure is achieved, improving the stability and repeatability of flow path switching during radionuclide separation.

[0017] In one embodiment of the present invention, switching the inlet multi-way valve to the pre-wetting liquid channel and the outlet multi-way valve to maintain the waste liquid channel, controlling the pump to advance according to the preset pre-wetting volume, and advancing according to the target channel pre-fill volume, includes: Step 21: Switch the inlet multi-way valve to the pre-wetting liquid channel and maintain it, while keeping the outlet multi-way valve in the waste liquid channel. The pre-wetting liquid channel refers to the inlet channel connected to the pre-wetting liquid source; the pre-wetting liquid is a liquid used to wet the separation medium or fill the flow path, and does not contain the target radioactive nuclide; the waste liquid channel refers to the output channel used to discharge non-target products or flushing liquid. In this valve position combination state, read the valve position signal. When the valve position signal indicates that both the inlet and outlet multi-way valves are in the correct position, record the initial reading of the pump's cumulative advance volume as the starting point for the pre-wetting volume advance. If the valve position signal is not in the correct position, stop the pump and keep the outlet multi-way valve in the waste liquid channel to avoid erroneous volume measurement when the valve position is unstable.

[0018] Step 22: Under the valve position holding condition of step 21, control the pump to advance the pre-wetting liquid in a volumetric advance manner. Subtract the starting point of the pre-wetting volume advance from the current cumulative pump advance volume to obtain the pre-wetting advance increment. When the pre-wetting advance increment reaches the preset pre-wetting volume, the pre-wetting liquid advance ends, and the cumulative pump advance volume at this time is recorded. The preset pre-wetting volume refers to the pre-set volume parameters used for wetting the separation column and its front-end flow path; this step ensures that the advance amount of the pre-wetting volume is consistent with the actual fluid displacement, without relying on time estimation or empirical judgment.

[0019] Step 23: Read the pre-charge volume of the target channel and record the cumulative pump advance volume at the end of Step 22 as the starting point for the target channel pre-charge volume advance. While keeping the inlet multi-way valve in the pre-wetting liquid channel and the outlet multi-way valve in the waste liquid channel, continue to control the pump to advance the pre-wetting liquid. Subtract the starting point for the target channel pre-charge volume advance from the current cumulative pump advance volume to obtain the advance increment. When the advance increment reaches the target channel pre-charge volume, the advance ends, and the cumulative pump advance volume is recorded. This pre-charge operation ensures that the flow path space associated with the target channel is completely filled with pre-wetting liquid, providing stable fluid boundary conditions for subsequent multi-way valve switching to the target collection channel.

[0020] Through the aforementioned pre-wetting and pre-charging processes, this invention achieves deterministic flow path preparation control based on volumetric measurement during radionuclide separation. The preset pre-wetting volume establishes the wetting state within the separation column and its upstream flow path, while the target channel pre-charging volume ensures the target collection channel is fully charged before formal switching. Both are based on the cumulative pump advance volume, forming a volumetric parameter system consistent with the dead volume of the outlet section and the quantitative clearing volume. This volumetric control method reduces separation instability caused by flow path residues or air entrainment, improving the repeatability and stability of multi-port valve switching during radionuclide separation.

[0021] In one embodiment of the present invention, to achieve volume control during the sample loading stage of radionuclide separation and safe handling of the flow path under abnormal conditions, after completing the pre-wetting and pre-filling operations, the inlet multi-way valve is switched to the feed liquid channel, and the outlet multi-way valve is kept in the waste liquid channel. The feed liquid is advanced based on volume metering control, and the system operating status is determined in real time using pressure signals. When the pressure signal exceeds the system's allowable pressure range, a safety flushing volume is executed. The specific process includes: Step 31: Switch the inlet multi-way valve to the feed channel and maintain it, while keeping the outlet multi-way valve in the waste channel. Read the valve position signal. When the valve position signal indicates that both the inlet and outlet multi-way valves are in the correct position in their respective channels, record the initial reading of the pump's cumulative advance volume as the starting point for the sample loading volume. The feed channel refers to the inlet channel connected to the source of the solution to be separated, which contains the target radionuclide. The sample loading volume refers to the pre-set volume parameter used to introduce a certain amount of feed into the separation column or adsorption medium. If the valve position signal is not in place, stop the pump and keep the outlet multi-way valve in the waste channel to avoid volume measurement when the valve position is unstable.

[0022] Step 32: Under the valve position holding condition of step 31, control the pump to advance the liquid feed, and continuously collect pressure signals during the advance process. Simultaneously, maintain continuous metering of the pump's cumulative advance volume without resetting it. The pressure signal is a measurement signal reflecting the fluid pressure state collected by a pressure sensor installed in the flow path. The sample advance increment is obtained by subtracting the sample advance starting point from the current cumulative advance volume. When the sample advance increment reaches the preset sample advance volume, the liquid feed is stopped, and the cumulative advance volume of the pump is recorded, thus completing the volume control of the sample advance stage. This volume determination method is based on the actual advance volume, avoiding errors that may arise from relying solely on time control.

[0023] Step 33: During the sample loading process, the pressure signal is continuously compared with the upper and lower limits of the system's allowable pressure range. The system's allowable pressure range is a pre-defined pressure range, including an upper and lower limit, used to characterize the pressure fluctuation range of the separation system under normal operating conditions. When the pressure signal is greater than the upper limit of the system's allowable pressure range or less than the lower limit, it is determined to be an abnormal pressure state. At this time, the feed liquid advance in step 32 is stopped, and the outlet multi-way valve is kept in the waste liquid channel. Subsequently, the inlet multi-way valve is switched to the inert liquid channel and kept there, and the pump is controlled to advance inert liquid according to the safe flushing volume, and the cumulative pump advance volume is recorded. The safe flushing volume refers to the volume parameter used to flush and restore the flow path when an abnormal pressure state is detected. Through this safe flushing operation, the separation column and related flow paths can be flushed in a volumetric manner, so that blockages, air resistance, or local concentration abnormalities that may exist under abnormal pressure states can be alleviated.

[0024] Through the above embodiments, this invention achieves intelligent switching control of multi-port valves in radionuclide separation based on a combination of volume measurement and pressure signal determination. The comparison between the pressure signal and the system's allowable pressure range constitutes an anomaly detection mechanism. When an anomaly occurs, the inlet multi-port valve is automatically switched to the inert liquid channel, and a safety flushing volume is executed, thereby avoiding fluctuations in separation performance or equipment damage caused by flow path anomalies. This control method links the switching action of the multi-port valve with volume and pressure parameters, achieving dynamic management of the flow path state in the separation process, which is beneficial for improving the controllability and repeatability of the radionuclide separation process.

[0025] In one embodiment of the present invention, to perform staged elution of the separation medium after the sample loading stage and to eliminate flow path residue between different elution stages, the inlet multi-port valve is sequentially switched to the first elution liquid channel and the second elution liquid channel, respectively, and the corresponding elution liquid is introduced by volume. After each elution stage, the gas source purge valve is opened to perform a purge operation according to the quantitative clearance volume. The first elution liquid channel and the second elution liquid channel are inlet channels connected to different elution liquid sources, respectively, and are used to sequentially remove impurity components with different binding strengths in the separation column. The specific process includes: Step 41: Switch the inlet multi-way valve to the first rinsing fluid channel and maintain it, while keeping the outlet multi-way valve in the waste fluid channel. Read the valve position signal. When the valve position signal indicates that both the inlet and outlet multi-way valves are in the correct position, record the initial reading of the pump's cumulative advance volume as the starting point for the first rinsing fluid advance. Subsequently, control the pump to advance the first rinsing fluid in a volume-based advance mode. Subtract the starting point for the first rinsing fluid advance from the current cumulative advance volume to obtain the advance increment. When the advance increment reaches the first rinsing fluid volume, the advance ends, and the cumulative advance volume is recorded. In this way, the actual advance volume of the first rinsing fluid remains consistent with the preset volume, forming a volume record for the first rinsing stage.

[0026] Step 42: After the first rinse fluid advance is completed, keep the outlet multi-way valve in the waste liquid channel. When the valve position indicator is in place, open and hold the air source purge valve, while simultaneously controlling the pump to advance the inert liquid according to the quantitative cleaning volume, and simultaneously complete the purging operation. The air source purge valve is a valve assembly connected to the air source, used to introduce gas to assist in the flow path replacement during volume advance; after the quantitative cleaning volume is reached, close the air source purge valve and record the purging record. If the valve position indicator is not in place during purging, immediately close the air source purge valve and stop the pump to avoid continuing volume advance under abnormal valve position conditions. By performing purging according to the quantitative cleaning volume, the liquid remaining in the flow path during the first rinse stage is replaced by volume, reducing the cross-influence between different stages.

[0027] Step 43: Switch the inlet multi-way valve to the second rinsing fluid channel and maintain it, while keeping the outlet multi-way valve in the waste fluid channel. With the valve position signal indicating it is in position, record the initial reading of the pump's cumulative advance volume as the starting point for the second rinsing fluid advance. Control the pump to advance the second rinsing fluid by volume. Subtract the starting point of the second rinsing fluid advance from the current cumulative advance volume to obtain the advance increment. Stop the advance when the advance increment reaches the second rinsing fluid volume, and record the cumulative advance volume. After the second rinsing fluid advance is complete, reopen the air source purging valve and advance inert liquid according to the metered cleaning line volume to complete the purging. Then close the air source purging valve and record the purging record. The first and second rinsing fluid volumes are preset volume parameters used to limit the advance volume of each rinsing fluid segment. Through the above embodiments, this invention achieves segmented volume control and inter-stage line-clearing control in the rinsing stage of radionuclide separation. The first and second rinsing solutions are advanced according to independent volume parameters, combined with a quantitative line-clearing volume purging operation, forming a sequential structure of rinsing, line clearing, rinsing, and line clearing. Each stage uses the cumulative volume advanced by the pump as a unified measurement benchmark, and the valve position signal serves as the interlocking condition, ensuring that multi-port valve switching and volume advancement actions are completed within the same control system. This volumetric and sequential rinsing and line-clearing control method helps reduce the risk of residual mixing between different rinsing stages, improving separation purity and process stability.

[0028] In one embodiment of the present invention, after the rinsing stage is completed, in order to determine the elution range of the target radionuclide and provide a basis for subsequent multi-port valve switching, the inlet multi-port valve is switched to the target eluent channel, and the outlet multi-port valve remains in the waste liquid channel. By smoothing the activity signal and setting window determination rules, an activity window entry signal and an activity window exit signal are generated, including: Step 51: Switch the inlet multi-port valve to the target eluent channel and maintain it, while keeping the outlet multi-port valve in the waste liquid channel. The target eluent channel refers to the inlet channel connected to the eluent source used to elute the target radionuclide from the separation medium. Read the valve position signal. When the valve position signal indicates that both the inlet and outlet multi-port valves are in the correct position, start collecting activity signals. If the valve position signal is not in the correct position, stop collecting and keep the outlet multi-port valve in the waste liquid channel; when the valve position signal returns to the correct position, restart collecting and re-enter the threshold holding time. By associating the collection conditions with the valve position signal, invalid data can be avoided when the valve position is unstable.

[0029] Step 52: During the activity signal acquisition process, continuous sampling is performed according to a preset sampling period, and the activity probe baseline is read synchronously. The activity deviation signal is obtained by subtracting the activity signal from the activity probe baseline. The activity deviation signals corresponding to the current sampling time and the preceding consecutive preset smoothing window lengths are grouped together. This group of activity deviation signals is summed to obtain a total, and then the sum is divided by the preset smoothing window length to obtain the smoothed activity signal. This smoothing process reduces the impact of instantaneous fluctuations on the determination result, making the activity signal more stably reflect the elution state.

[0030] Step 53: Read the product activity window entry threshold, product activity window exit threshold, and threshold holding time. The product activity window entry threshold and product activity window exit threshold are preset activity judgment thresholds used to determine the start and end of target nuclide elution. When the smoothed activity signal is not less than the product activity window entry threshold, the threshold holding time begins to accumulate. When the condition is not met, the accumulated value is cleared to zero. When the accumulated threshold holding time is reached, an activity window entry signal is generated. The threshold holding time refers to the shortest time for the smoothed activity signal to continuously meet the threshold condition. Correspondingly, when the smoothed activity signal is not greater than the product activity window exit threshold, an activity window exit signal is generated according to the same accumulation rule. By setting the entry and exit thresholds and combining them with the threshold holding time for continuous judgment, a stable identification logic for the target elution interval can be formed.

[0031] Through the above implementation methods, this invention establishes a window determination mechanism based on smoothed activity signals during the radionuclide separation process, combining activity signal processing with multi-port valve switching control logic. The activity window entry and exit signals serve as the triggering basis for the subsequent execution of the three-stage zero-residue switching unit, ensuring that the switching of the target collection channel matches the actual elution state. This control method avoids the uncertainties caused by relying solely on time estimation or manual judgment for switching, improving the automation and consistency of multi-port valve switching control in radionuclide separation.

[0032] In one embodiment of the present invention, in response to an activity window entry signal or an activity window exit signal, a three-stage zero-residue switching unit is invoked to sequentially execute and switch to the target collection channel according to the isolation section volume, quantitative cleaning volume, and target channel pre-filling volume, including: Step 61: When the activity window enters or exits, the valve position signal is read first. If the valve position signal indicates that the outlet multi-way valve is in the correct position, the three-stage zero-residue switching unit is invoked; if the valve position signal is not in the correct position, the pump is stopped and the outlet multi-way valve remains in the waste liquid channel until the valve position signal is restored to the correct position before invoking the three-stage zero-residue switching unit. The three-stage zero-residue switching unit refers to a control process unit that executes in the order of isolation section volume, quantitative cleaning volume, and target channel pre-filling volume. By associating the triggering of the switching process with the valve position signal, subsequent volume propulsion operations are ensured only when the valve position is stable.

[0033] Step 62: During the isolation section execution phase, switch the outlet multi-way valve to the waste liquid channel and maintain it. Record the initial reading of the pump's cumulative advance volume as the starting point of the isolation section advance. Then, control the pump to advance the inert liquid. Subtract the starting point of the isolation section advance from the current cumulative advance volume to obtain the advance increment. When the advance increment reaches the isolation section volume, the advance ends, and the pump's cumulative advance volume is recorded. The isolation section volume refers to the volume parameter required to separate the fluid in the current flow path that has not yet entered the target zone from the fluid in the target zone after the activity window signal is triggered. By advancing the isolation section volume, the fluid boundary before and after the activity window trigger moment is separated in volume.

[0034] Step 63: During the quantitative cleaning stage, keep the outlet multi-way valve in the waste liquid channel, open and maintain the air source purge valve, and control the pump to advance the inert liquid according to the quantitative cleaning volume while simultaneously completing the purging operation. If the valve position signal is not received during purging, close the air source purge valve and stop the pump. After advancing to the quantitative cleaning volume, close the air source purge valve. This volumetric cleaning operation can replace the residual fluid in the flow path, creating stable fluid conditions for subsequent switching to the target collection channel.

[0035] Switch the outlet multi-way valve to the target collection channel and maintain it, recording the initial reading of the pump's cumulative advance volume as the starting point for the target channel pre-charge volume advance. The target collection channel refers to the output channel used to collect the eluent for the target radionuclide. Control the pump to continue advancing the inert liquid, subtracting the target channel pre-charge volume advance starting point from the current pump's cumulative advance volume to obtain the advance increment. When the advance increment reaches the target channel pre-charge volume, the advance stops, and the pump's cumulative advance volume is recorded. By advancing the target channel pre-charge volume, the fluid within the target collection channel can be kept in a continuous and stable state, thus providing a defined fluid boundary for the formal collection of the target radionuclide.

[0036] Through the above embodiments, this invention combines the activity window determination result with multi-port valve switching control to form a three-stage sequential switching structure centered on volume parameters during the radionuclide separation process. The isolation section volume is used to establish physical volume isolation, the quantitative cleaning line volume is used to eliminate flow path residues, and the target channel pre-filling volume is used to establish stable fluid conditions for the target collection channel. This sequential control method can reduce the risk of fluid contamination between different stages, improve the purity and stability of the target nuclide collection interval, and match the switching behavior of the multi-port valve with the actual separation state.

[0037] In one embodiment of the present invention, after elution, the inlet multi-way valve is switched to the cleaning fluid channel, the outlet multi-way valve remains in the waste fluid channel, the pump advances according to the cleaning volume and purges according to the quantitative cleaning volume, resets to the default safe position, and records the cumulative pump advance volume, including: Step 71: Switch the inlet multi-way valve to the cleaning fluid channel and maintain it, while keeping the outlet multi-way valve in the waste fluid channel. The cleaning fluid channel refers to the inlet channel connected to the cleaning fluid source. The cleaning fluid is used to flush the separation column and flow path to remove residues. Read the valve position signal. When the valve position signal indicates that both the inlet and outlet multi-way valves are in the correct position, record the initial reading of the pump's cumulative advance volume as the starting point for the cleaning volume advance. The cleaning volume is used to limit the advance amount of cleaning fluid. If the valve position signal is not in the correct position, stop the pump and keep the outlet multi-way valve in the waste fluid channel to ensure that volume measurement is not performed if the valve position is not stable.

[0038] Step 72: With the valve position maintained, control the pump to advance the cleaning fluid. Subtract the starting point of the cleaning volume advance from the current cumulative pump advance volume to obtain the cleaning advance increment. When the cleaning advance increment reaches the cleaning volume, the advance stops, and the cumulative pump advance volume is recorded. This volumetric determination method ensures that the cleaning fluid advance volume is consistent with the set value, providing stable fluid conditions for subsequent purging.

[0039] Step 73: Keep the outlet multi-way valve in the waste liquid channel and open the air source purge valve. Record the initial reading of the pump's cumulative advance volume as the starting point for the quantitative clearing volume advance. Control the pump to advance the inert liquid, and subtract the quantitative clearing volume advance starting point from the current cumulative advance volume to obtain the advance increment. When the advance increment reaches the quantitative clearing volume, stop the advance and close the air source purge valve. At the same time, record the pump's cumulative advance volume at the end of the quantitative clearing volume advance. If the valve position signal is not received during the purge, close the air source purge valve and stop the pump to prevent the advance operation from continuing under abnormal valve position conditions.

[0040] After cleaning and purging are completed, the inlet multi-way valve is reset to the inert liquid channel, and the outlet multi-way valve is reset to the waste liquid channel, forming the default safe position. The default safe position refers to the preset valve position combination state. In this state, the inlet multi-way valve is in the inert liquid channel and the outlet multi-way valve is in the waste liquid channel, so that the system is in a safe standby state with no target material input and the flow path leading to the waste liquid end. The valve position signal is read to confirm that the position is in place, and the cumulative pump push volume at the time of reset is recorded. Through this reset and recording operation, the termination volume boundary of one radionuclide separation process is formed.

[0041] Through the above embodiments, this invention establishes a standardized cleaning and reset control process after elution in the separation of radionuclides. Both the cleaning volume and the quantitative cleaning line volume are deterministically measured based on the cumulative pump advance volume, ensuring clear volume limits for the flow path processing in the final stage. The default safety setting ensures the system is in a stable state with no target material input after the process ends. This volumetric and sequential cleaning and reset control method links the switching action of the multi-way valve with the flow path cleanliness and system safety status, improving the integrity and consistency of intelligent switching control of multi-way valves in radionuclide separation.

[0042] In one embodiment of the present invention, in order to maintain a clear timing relationship between the activity window entry signal and the activity window exit signal during the generation process, after the activity window entry signal is generated, the generation of the activity window entry signal is stopped, and the generation determination of the activity window exit signal is performed only on the smoothed activity signal; after the activity window exit signal is generated, the generation of the activity window exit signal is stopped, and the generation determination of the activity window entry signal is performed only on the smoothed activity signal.

[0043] Specifically, during the smoothing of the activity signal and the execution of the threshold determination logic, the system operates in one of two mutually exclusive determination states. When the smoothed activity signal meets the entry determination condition and generates an activity window entry signal, the system stops determining the generation of the activity window entry signal; that is, it no longer accumulates and determines the entry threshold and the corresponding threshold holding time. Simultaneously, it only performs the generation and determination of the activity window exit signal for the smoothed activity signal. In this state, the system continuously compares the smoothed activity signal with the product activity window exit threshold and accumulates and determines the threshold holding time according to the threshold holding time rules.

[0044] Once the smoothed activity signal meets the exit condition and generates an activity window exit signal, the system stops generating and determining the activity window exit signal and restarts the generation and determination of the activity window entry signal only for the smoothed activity signal. This forms a control structure that alternately enables entry and exit determination, ensuring that only one type of activity window signal generation and determination logic is active at any given time.

[0045] Through the above embodiments, this invention provides state-based management of the activity window determination logic during radionuclide separation. The mutual exclusion relationship between entry and exit determinations ensures a clear temporal sequence between the activity window entry and exit signals, preventing repeated or cross-triggered events due to signal fluctuations near the elution interval boundaries. This determination structure, in conjunction with the three-stage zero-residue switching unit of the multi-port valve, ensures that the switching of the target collection channel is performed only at clearly defined activity interval boundaries, thereby improving the stability and consistency of the intelligent switching control of the multi-port valve during radionuclide separation.

[0046] In one embodiment of the present invention, an intelligent switching control system for a multi-port valve in radionuclide separation is also provided, comprising: The dead volume determination module is used to switch the outlet multi-way valve to the waste liquid channel and the inlet multi-way valve to the inert liquid channel, control the pump to push inert liquid and record the dead volume of the outlet section, and determine the quantitative cleaning volume and the pre-fill volume of the target channel. The pre-wetting and pre-filling module is used to switch the inlet multi-way valve to the pre-wetting liquid channel, keep the outlet multi-way valve in the waste liquid channel, control the pump to advance according to the preset pre-wetting volume, and advance according to the target channel pre-filling volume; The sample loading safety control module is used to switch the inlet multi-way valve to the liquid channel, keep the outlet multi-way valve in the waste channel, control the pump to advance according to the sample loading volume, and execute the safety flushing volume according to the pressure signal; The segmented rinsing and cleaning module is used to sequentially switch the inlet multi-way valve to the first rinsing liquid channel and the second rinsing liquid channel, and advance by volume, open the air source purging valve and perform purging according to the quantitative cleaning volume; The activity window determination module is used to switch the inlet multi-way valve to the target eluent channel and the outlet multi-way valve to maintain the waste liquid channel, collect the activity signal, calculate the smoothed activity signal, and generate the activity window entry signal and the activity window exit signal. The zero-residue switching module is used to respond to the activity window entry signal or the activity window exit signal to call the three-stage zero-residue switching unit, and execute and switch to the target collection channel in sequence according to the isolation section volume, quantitative cleaning volume, and target channel pre-filling volume; The termination cleaning reset module is used to switch the inlet multi-way valve to the cleaning fluid channel and the outlet multi-way valve to the waste fluid channel after elution. It advances according to the cleaning volume and purges according to the quantitative cleaning volume, resets to the default safety position, and records the cumulative volume advanced by the pump.

[0047] It should be noted that the range and threshold size are set for ease of comparison. The size of the threshold depends on the amount of sample data and the number of bases set by those skilled in the art for each set of sample data, as long as it does not affect the ratio between the parameter and the quantized value.

[0048] The embodiments of the present invention have been described above, but the present invention is not limited to the specific embodiments described above. The specific embodiments described above are merely illustrative and not restrictive. Those skilled in the art can make many other forms based on the guidance of the present embodiments, all of which are within the protection scope of the present embodiments.

Claims

1. An intelligent switching control method for multi-port valves in radionuclide separation, characterized in that, Includes the following steps: Step 1: Switch the outlet multi-way valve to the waste liquid channel and the inlet multi-way valve to the inert liquid channel. Control the pump to push inert liquid and record the dead volume of the outlet section. Determine the quantitative cleaning volume and the pre-filling volume of the target channel. Step 2: Switch the inlet multi-way valve to the pre-wetting liquid channel, keep the outlet multi-way valve in the waste liquid channel, control the pump to advance according to the preset pre-wetting volume, and advance according to the target channel pre-fill volume; Step 3: Switch the inlet multi-way valve to the feed liquid channel and the outlet multi-way valve to the waste liquid channel. Control the pump to advance according to the sample loading volume and execute the safety flushing volume according to the pressure signal. Step 4: Switch the inlet multi-port valve to the first rinsing liquid channel and the second rinsing liquid channel in sequence, and advance according to volume. Open the air source purging valve and perform purging according to the quantitative cleaning volume. Step 5: Switch the inlet multi-way valve to the target eluent channel and the outlet multi-way valve to keep the waste liquid channel. Collect the activity signal, calculate the smoothed activity signal, and generate the activity window entry signal and activity window exit signal. Step 6: In response to the activity window entry signal or activity window exit signal, the three-stage zero-residue switching unit is invoked, and the isolation section volume, quantitative cleaning volume, and target channel pre-filling volume are executed sequentially and switched to the target collection channel. Step 7: After elution is complete, switch the inlet multi-way valve to the cleaning fluid channel and the outlet multi-way valve to the waste fluid channel. Advance according to the cleaning volume and purge according to the quantitative cleaning volume. Reset to the default safe position and record the cumulative advance volume of the pump.

2. The intelligent switching control method for multi-port valves in radionuclide separation according to claim 1, characterized in that, Switch the outlet multi-way valve to the waste liquid channel and the inlet multi-way valve to the inert liquid channel. Control the pump to push inert liquid and record the dead volume of the outlet section. Determine the quantitative cleaning volume and the target channel pre-fill volume, including: Step 11: Switch the outlet multi-way valve to the waste liquid channel and keep it there; switch the inlet multi-way valve to the inert liquid channel and keep it there. When the valve position signal indicates that both the outlet multi-way valve and the inlet multi-way valve are in position, determine the starting reading of the pump's cumulative propulsion volume as the starting point of the volume propulsion metering, and keep the valve position signal in position until the dead volume recording of the outlet section is completed. Step 12: Under the conditions maintained in step 11, control the pump to continuously push inert liquid and collect activity signals. Subtract the activity signal from the baseline of the activity probe to obtain the activity deviation signal. When the activity deviation signal is not less than a preset threshold and continues to reach a preset duration, trigger the arrival criterion event. At the trigger time of the arrival criterion event, read the cumulative volume pushed by the pump and record it as the dead volume of the liquid outlet section. Step 13: Read the dead volume of the liquid outlet section and determine it as the pre-fill volume of the target channel. Multiply the quantitative clearing multiple by the dead volume of the liquid outlet section to obtain the quantitative clearing volume. The quantitative clearing multiple is a pre-stored fixed integer that remains unchanged in the same radionuclide separation process.

3. The intelligent switching control method for multi-port valves in radionuclide separation according to claim 1, characterized in that, Switch the inlet multi-way valve to the pre-wetting liquid channel, keep the outlet multi-way valve in the waste liquid channel, control the pump to advance according to the preset pre-wetting volume, and advance according to the target channel pre-fill volume, including: Step 21: Switch the inlet multi-way valve to the pre-wetting liquid channel and keep it there, and keep the outlet multi-way valve in the waste liquid channel; when the valve position signal indicates that both the inlet multi-way valve and the outlet multi-way valve are in position, record the starting reading of the pump's cumulative advance volume as the starting point of the pre-wetting volume advance; if the valve position signal is not in position, stop the pump and keep the outlet multi-way valve in the waste liquid channel. Step 22: Under the condition of maintaining the valve position in step 21, control the pump to advance the pre-wetting liquid according to the preset pre-wetting volume; subtract the starting point of the pre-wetting volume advance from the current cumulative advance volume of the pump to obtain the pre-wetting advance increment; when the pre-wetting advance increment reaches the preset pre-wetting volume, the advance is stopped and the cumulative advance volume of the pump is recorded. Step 23: Read the pre-fill volume of the target channel and record the cumulative pump propulsion volume at the end of Step 22 as the starting point for the pre-fill volume propulsion of the target channel; control the pump to continue propulsing the pre-wetting liquid, subtract the starting point for the pre-fill volume propulsion of the target channel from the current cumulative pump propulsion volume to obtain the propulsion increment, and stop propulsion when the propulsion increment reaches the pre-fill volume of the target channel and record the cumulative pump propulsion volume.

4. The intelligent switching control method for multi-port valves in radionuclide separation according to claim 1, characterized in that, Switch the inlet multi-way valve to the feed channel and the outlet multi-way valve to the waste channel. Control the pump to advance according to the sample loading volume, and execute the safety flushing volume according to the pressure signal, including: Step 31: Switch the inlet multi-way valve to the feed liquid channel and keep it there, and keep the outlet multi-way valve in the waste liquid channel; when the valve position signal indicates that both the inlet multi-way valve and the outlet multi-way valve are in position, record the initial reading of the cumulative pump advance volume as the starting point of the sample loading volume; if the valve position signal is not in position, stop the pump and keep the outlet multi-way valve in the waste liquid channel. Step 32: Under the valve position holding condition in step 31, control the pump to advance the liquid and collect the pressure signal, and keep the pump's cumulative advance volume continuously measured during the advance; subtract the starting point of the sample advance volume from the current cumulative advance volume of the pump to obtain the sample advance increment; when the sample advance increment reaches the sample volume, the advance ends and the pump's cumulative advance volume is recorded. Step 33: Compare the pressure signal with the upper and lower limits of the system pressure allowable range; when the pressure signal is greater than the upper limit of the system pressure allowable range or less than the lower limit of the system pressure allowable range, stop the advancement in step 32 and keep the outlet multi-way valve in the waste liquid channel, switch the inlet multi-way valve to the inert liquid channel and keep it there, control the pump to advance the inert liquid according to the safe flushing volume and record the cumulative advance volume of the pump.

5. The intelligent switching control method for multi-port valves in radionuclide separation according to claim 1, characterized in that, The inlet multi-port valve is sequentially switched to the first and second rinsing fluid channels, and the flow is advanced by volume. The air source purging valve is opened, and purging is performed according to the quantitative cleaning volume, including: Step 41: Switch the inlet multi-way valve to the first rinsing liquid channel and keep it there, and keep the outlet multi-way valve in the waste liquid channel; when the valve position signal is in place, record the initial reading of the pump's cumulative propulsion volume as the starting point of the first rinsing liquid propulsion, control the pump to propel the first rinsing liquid by volume, subtract the starting point of the first rinsing liquid propulsion from the current cumulative propulsion volume of the pump to obtain the propulsion increment, and stop propulsion when the propulsion increment reaches the volume of the first rinsing liquid and record the cumulative propulsion volume of the pump; Step 42: Keep the outlet multi-way valve in the waste liquid channel. When the valve position signal is in place, open the air source purging valve and keep it open. Control the pump to advance the inert liquid according to the metered cleaning volume and complete the purging simultaneously. After the advance is completed, close the air source purging valve and record the purging record. If the valve position signal is not in place during the purging process, close the air source purging valve and stop the pump. Step 43: Switch the inlet multi-way valve to the second rinsing liquid channel and maintain it, while keeping the outlet multi-way valve in the waste liquid channel; when the valve position signal is in place, record the initial reading of the pump's cumulative advance volume as the starting point for the second rinsing liquid advance, control the pump to advance the second rinsing liquid by volume, subtract the starting point for the second rinsing liquid advance from the current cumulative advance volume of the pump to obtain the advance increment, and stop the advance when the advance increment reaches the volume of the second rinsing liquid and record the cumulative advance volume of the pump; then open the air source purging valve and advance the inert liquid according to the quantitative cleaning line volume to complete the purging, close the air source purging valve and record the purging record.

6. The intelligent switching control method for multi-port valves in radionuclide separation according to claim 1, characterized in that, Switch the inlet multi-way valve to the target eluent channel and the outlet multi-way valve to maintain the waste liquid channel. Collect the activity signal, calculate the smoothed activity signal, and generate the activity window entry signal and activity window exit signal, including: Step 51: Switch the inlet multi-way valve to the target eluent channel and keep it there, and keep the outlet multi-way valve in the waste liquid channel; start collecting activity signals when the valve position signal indicates that both the inlet and outlet multi-way valves are in position; stop collecting when the valve position signal is not in position and keep the outlet multi-way valve in the waste liquid channel; start collecting again and re-enter the threshold holding time when the valve position signal returns to position. Step 52: Acquire activity signals according to a preset sampling period and read the activity probe baseline. Subtract the activity signal from the activity probe baseline to obtain the activity deviation signal. Take the activity deviation signals corresponding to the current sampling time and the consecutive preset smoothing window lengths before it as a group, accumulate the group of activity deviation signals to obtain a sum, and divide the sum by the preset smoothing window length to obtain the smoothed activity signal. Step 53: Read the product activity window entry threshold, product activity window exit threshold, and threshold holding time; when the smoothed activity signal is not less than the product activity window entry threshold, start accumulating the threshold holding time; if the condition is not met, the accumulation will be cleared to zero; when the accumulation reaches the threshold holding time, generate the activity window entry signal; when the smoothed activity signal is not greater than the product activity window exit threshold, accumulate according to the same rule and generate the activity window exit signal.

7. The intelligent switching control method for multi-port valves in radionuclide separation according to claim 1, characterized in that, The activity window entry signal or activity window exit signal triggers the three-stage zero-residue switching unit, sequentially executing the isolation section volume, quantitative cleaning volume, and target channel pre-filling volume, and switching to the target collection channel, including: Step 61: When the activity window enters or exits, read the valve position signal; when the valve position signal indicates that the outlet multi-way valve is in position, call the three-stage zero-residue switching unit; when the valve position signal is not in position, stop the pump and keep the outlet multi-way valve in the waste liquid channel; when the valve position signal is restored to position, call the three-stage zero-residue switching unit again. Step 62: Switch the outlet multi-way valve to the waste liquid channel and keep it there. Record the initial reading of the pump's cumulative propulsion volume as the starting point of the isolation section propulsion. Control the pump to propel the inert liquid. Subtract the starting point of the isolation section propulsion from the current cumulative propulsion volume of the pump to obtain the propulsion increment. When the propulsion increment reaches the isolation section volume, stop propulsion and record the pump's cumulative propulsion volume. Step 63: Keep the outlet multi-way valve in the waste liquid channel, open the air source purging valve and control the pump to advance the inert liquid according to the quantitative cleaning volume. If the valve position signal is not in place during the purging period, close the air source purging valve and stop the pump. After the quantitative cleaning volume is advanced, close the air source purging valve, switch the outlet multi-way valve to the target collection channel and keep it there. Record the initial reading of the pump's cumulative advance volume as the starting point for the target channel pre-charge volume advancement. Control the pump to advance the inert liquid. Subtract the target channel pre-charge volume advancement starting point from the current pump's cumulative advance volume to obtain the advancement increment. When the advancement increment reaches the target channel pre-charge volume, end the advancement and record the pump's cumulative advance volume.

8. The intelligent switching control method for multi-port valves in radionuclide separation according to claim 1, characterized in that, After elution, switch the inlet multi-way valve to the cleaning fluid channel and the outlet multi-way valve to the waste fluid channel. Propel the pump according to the cleaning volume and purge according to the metered cleaning line volume. Reset to the default safety position and record the pump's cumulative propulsion volume, including: Step 71: Switch the inlet multi-way valve to the cleaning fluid channel and keep it there, and keep the outlet multi-way valve in the waste fluid channel; when the valve position signal indicates that both the inlet multi-way valve and the outlet multi-way valve are in position, record the initial reading of the pump's cumulative advance volume as the starting point of the cleaning volume advance; when the valve position signal is not in position, stop the pump and keep the outlet multi-way valve in the waste fluid channel. Step 72: Control the pump to advance the cleaning fluid. Subtract the starting point of the cleaning volume from the current cumulative volume advanced by the pump to obtain the cleaning advance increment. When the cleaning advance increment reaches the cleaning volume, the advancement ends and the cumulative volume advanced by the pump is recorded. Step 73: Keep the outlet multi-way valve in the waste liquid channel and open the air source purge valve. Record the initial reading of the pump's cumulative advance volume as the starting point for the quantitative clearing volume advance. Control the pump to advance the inert liquid. Subtract the starting point for the quantitative clearing volume advance from the current cumulative advance volume of the pump to obtain the advance increment. When the advance increment reaches the quantitative clearing volume, stop the advance and close the air source purge valve. Record the cumulative advance volume of the pump at the end of the quantitative clearing volume advance. If the valve position signal is not in place during the purge, close the air source purge valve and stop the pump. Reset the inlet multi-way valve to the inert liquid channel and the outlet multi-way valve to the waste liquid channel as the default safety position. Read the valve position signal to confirm that it is in place and record the cumulative advance volume of the pump when the reset is completed.

9. The intelligent switching control method for multi-port valves in radionuclide separation according to claim 1, characterized in that, After generating the activity window entry signal, stop generating the activity window entry signal and only perform the generation determination of the activity window exit signal for the smoothed activity signal; after generating the activity window exit signal, stop generating the activity window exit signal and only perform the generation determination of the activity window entry signal for the smoothed activity signal.

10. An intelligent switching control system for multi-port valves in radionuclide separation, characterized in that, The intelligent switching control method for multi-port valves in radionuclide separation as described in any one of claims 1-9 includes: The dead volume determination module is used to switch the outlet multi-way valve to the waste liquid channel and the inlet multi-way valve to the inert liquid channel, control the pump to push inert liquid and record the dead volume of the outlet section, and determine the quantitative cleaning volume and the pre-fill volume of the target channel. The pre-wetting and pre-filling module is used to switch the inlet multi-way valve to the pre-wetting liquid channel, keep the outlet multi-way valve in the waste liquid channel, control the pump to advance according to the preset pre-wetting volume, and advance according to the target channel pre-filling volume; The sample loading safety control module is used to switch the inlet multi-way valve to the liquid channel, keep the outlet multi-way valve in the waste channel, control the pump to advance according to the sample loading volume, and execute the safety flushing volume according to the pressure signal; The segmented rinsing and cleaning module is used to sequentially switch the inlet multi-way valve to the first rinsing liquid channel and the second rinsing liquid channel, and advance by volume, open the air source purging valve and perform purging according to the quantitative cleaning volume; The activity window determination module is used to switch the inlet multi-way valve to the target eluent channel and the outlet multi-way valve to maintain the waste liquid channel, collect the activity signal, calculate the smoothed activity signal, and generate the activity window entry signal and the activity window exit signal. The zero-residue switching module is used to respond to the activity window entry signal or the activity window exit signal to call the three-stage zero-residue switching unit, and execute and switch to the target collection channel in sequence according to the isolation section volume, quantitative cleaning volume, and target channel pre-filling volume; The termination cleaning reset module is used to switch the inlet multi-way valve to the cleaning fluid channel and the outlet multi-way valve to the waste fluid channel after elution. It advances according to the cleaning volume and purges according to the quantitative cleaning volume, resets to the default safety position, and records the cumulative volume advanced by the pump.

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