An antibacterial and anti-mite shampoo and its preparation method

Abstract

This invention relates to the field of shampoo technology, and discloses an antibacterial and anti-mite shampoo and its preparation method. The antibacterial and anti-mite shampoo is prepared from piroctone ethanolamine salt, glycerin, a mixed phase, behenamidopropyl dimethylamine, citric acid aqueous solution, chlorhexidine gluconate aqueous solution, bis-PEG-15 methyl ether polydimethylsiloxane, lemon fragrance, phenoxyethanol preservative, deionized water, and sodium chloride. The mixed phase is prepared from sodium lauryl ether sulfate, cocamidopropyl betaine, glycerin, and an aqueous phase. The aqueous phase is prepared from deionized water, disodium ethylenediaminetetraacetate, and polyquaternium-10. This invention has good antibacterial and anti-mite effects.

Description

Technical Field

[0001] This invention relates to the field of shampoo technology, specifically to an antibacterial and anti-mite shampoo and its preparation method. Background Technology

[0002] In the field of personal care and daily chemical products, the proliferation of bacteria and fungi, as well as the parasitic presence of mites, can easily lead to a series of adverse problems, such as irritating human skin or hair, causing discomfort symptoms such as itching, sensitivity, increased dandruff, and dry and frizzy hair. In severe cases, it can even induce skin inflammation and endanger human health.

[0003] Patent CN114681365B discloses a shampoo with both oil-control and mite-removing effects, and its preparation method, belonging to the field of cosmetic technology. The natural ingredient composition consists of the following components: 1-6 parts of Dictamnus dasycarpus root bark, 2-14 parts of Platycladus orientalis leaf, 3-15 parts of Cnidium monnieri fruit, 1-10 parts of Stemona japonica root, 1-15 parts of Atractylodes lancea rhizome, 2-15 parts of Ginkgo biloba and Lithospermum erythrorhizon root, and 2-16 parts of Salvia miltiorrhiza root. The mixture is freeze-pulverized into plant powder, then soaked in an alkaline solution, subjected to ultrasonication, enzymatic hydrolysis, alcohol extraction, and filtration. The residue is repeatedly extracted 2-3 times. The extracts are combined, adsorbed by activated carbon, filtered, and the resulting plant extract is added to the shampoo. However, this prior art has poor antibacterial properties and cannot meet user needs. Summary of the Invention

[0004] The purpose of this invention is to provide an antibacterial and anti-mite shampoo and its preparation method, so as to solve the problems existing in the prior art.

[0005] To solve the above-mentioned technical problems, the present invention provides the following technical solution: An antibacterial and anti-mite shampoo, wherein the antibacterial and anti-mite shampoo is prepared from piroctone ethanolamine salt, glycerin, a mixed phase, behenamidopropyl dimethylamine, citric acid aqueous solution, chlorhexidine gluconate aqueous solution, bis-PEG-15 methyl ether polydimethylsiloxane, lemon fragrance, phenoxyethanol preservative, deionized water and sodium chloride; the mixed phase is prepared from sodium lauryl ether sulfate, cocamidopropyl betaine, glycerin and an aqueous phase; the aqueous phase is prepared from deionized water, disodium ethylenediaminetetraacetate and polyquaternium-10.

[0006] Furthermore, the citric acid aqueous solution has a mass fraction of 45-55%.

[0007] Furthermore, the mass fraction of the chlorhexidine gluconate aqueous solution is 20-30%.

[0008] A method for preparing an antibacterial and anti-mite shampoo includes the following steps: (1) Add deionized water to the reactor, add disodium ethylenediaminetetraacetate and polyquaternium-10 while stirring at 50-100 rpm, then heat to 75-80℃ and continue stirring for 30-40 minutes to obtain the aqueous phase; (2) Sodium lauryl ether sulfate, cocamidopropyl betaine and glycerol are mixed in a reactor and stirred at 150-250 rpm for 10-15 minutes at 25±5℃ to obtain a surfactant phase; the surfactant phase is slowly added to the aqueous phase obtained in step (1) at 75-80℃ and stirred at 200-300 rpm. After the addition is complete, stirring is continued for 15-25 minutes to obtain a mixed phase; (3) Heat behenamidopropyl dimethylamine to 80-85°C to melt it into a liquid; mix piroctone ethanolamine salt and glycerol to obtain a slurry; add the slurry to the mixed phase obtained in step (2), stir at 200-300 rpm for 10-20 minutes, then slowly add the molten behenamidopropyl dimethylamine over 5-10 minutes at 80-85°C and 200-300 rpm, and then stir at 800-1200 rpm for 3 minutes. After cooling to 40-45℃ for 5 minutes, adjust the pH value with citric acid aqueous solution. Then, at 40-45℃ and a stirring speed of 100-200 rpm, add chlorhexidine gluconate aqueous solution, bis-PEG-15 methyl ether polydimethylsiloxane, lemon fragrance, phenoxyethanol preservative and deionized water in sequence. Stir for 10-20 minutes after each material is added. Then add sodium chloride and continue stirring for 20-30 minutes. After cooling to 30-40℃, discharge the material to obtain the antibacterial and anti-mite shampoo.

[0009] Furthermore, in step (1), the mass ratio of deionized water, disodium ethylenediaminetetraacetate, and polyquaternium-10 is 650-700:0.1-0.3:1-2.

[0010] Furthermore, in step (2), the mass ratio of the aqueous phase, sodium lauryl ether sulfate, cocamidopropyl betaine, and glycerol is 600-700:150-180:40-60:5-10.

[0011] Furthermore, in step (2), the surfactant phase is slowly added to the aqueous phase over 10-15 minutes.

[0012] Furthermore, in step (3), the mass ratio of the mixed phase, pyrrolidone ethanolamine salt, glycerol, behenamidopropyl dimethylamine, chlorhexidine gluconate aqueous solution, bis-PEG-15 methyl ether polydimethylsiloxane, lemon flavor, phenoxyethanol preservative, deionized water and sodium chloride is 800-900:0.5-1.0:4-6:5-8:10-20:3-6:0.5-2.0:0.5-1.0:5-15:5-15.

[0013] Furthermore, in step (3), the pH value is adjusted to 5.5-6.0 using an aqueous solution of citric acid.

[0014] Furthermore, in step (3), behenamidopropyl dimethylamine is preheated to melt it into a liquid.

[0015] Compared with the prior art, the beneficial effects achieved by the present invention are: 1. This invention uses chlorhexidine gluconate as a broad-spectrum antibacterial agent. Its biguanide group can adsorb onto the negatively charged bacterial cell membrane through electrostatic interaction, disrupting the membrane structure and causing leakage of cell contents. It also uses behenamidopropyl dimethylamine as a cationic conditioning and synergistic antibacterial agent. In a weakly acidic environment regulated by citric acid, the tertiary amine group in its molecule undergoes protonation, transforming into a positively charged ammonium salt structure. This not only adsorbs onto hair strands through its cationic properties to provide conditioning, but also synergistically works with chlorhexidine gluconate to enhance the antimicrobial activity against microbial cells. The product exhibits strong penetration and destructive effects on the membrane and the cuticle of mites. It utilizes piroctone ethanolamine salt, whose molecules effectively inhibit fungal cell membrane synthesis and disrupt cell membrane integrity. The cationic properties of behenamidopropyl dimethylamine allow it to adhere to the hair surface, providing antistatic and softening effects. Bis-PEG-15 methyl ether polydimethylsiloxane, as a water-soluble silicone oil, forms a lubricating film on the hair, improving dry and wet combing performance. The protonated behenamidopropyl dimethylamine, chlorhexidine gluconate, and piroctone ethanolamine salt work synergistically to achieve excellent antibacterial and mite-removing effects. Detailed Implementation

[0016] The following embodiments are provided to better understand the present invention and are not limited to the preferred embodiments described. They do not constitute a limitation on the content and scope of protection of the present invention. Any product that is the same as or similar to the present invention, derived by any person under the guidance of the present invention or by combining the features of the present invention with other prior art, falls within the protection scope of the present invention.

[0017] An antibacterial and anti-mite shampoo, wherein the antibacterial and anti-mite shampoo is prepared from piroctone ethanolamine salt, glycerin, a mixed phase, behenamidopropyl dimethylamine, citric acid aqueous solution, chlorhexidine gluconate aqueous solution, bis-PEG-15 methyl ether polydimethylsiloxane, lemon fragrance, phenoxyethanol preservative, deionized water and sodium chloride; the mixed phase is prepared from sodium lauryl ether sulfate, cocamidopropyl betaine, glycerin and an aqueous phase; the aqueous phase is prepared from deionized water, disodium ethylenediaminetetraacetate and polyquaternium-10.

[0018] For experiments not specifically described in the examples, the procedures or conditions should be followed according to the conventional experimental procedures described in the literature in this field. Reagents or instruments whose manufacturers are not specified are all commercially available conventional reagent products.

[0019] Example 1

[0020] (1) Add deionized water to the reactor, add disodium ethylenediaminetetraacetate and polyquaternium salt-10 at a stirring speed of 50 rpm, then heat to 75°C and continue stirring for 30 minutes to obtain an aqueous phase; wherein the mass ratio of deionized water, disodium ethylenediaminetetraacetate and polyquaternium salt-10 is 650:0.1:1.

[0021] (2) Sodium lauryl ether sulfate, cocamidopropyl betaine and glycerol are mixed in a reactor and stirred at 150 rpm for 10 minutes at 25±5℃ to obtain a surfactant phase; the surfactant phase is slowly added to the aqueous phase obtained in step (1) at 75℃ within 10 minutes and stirred at 200 rpm. After the addition is completed, stirring is continued for 15 minutes to obtain a mixed phase; wherein the mass ratio of aqueous phase, sodium lauryl ether sulfate, cocamidopropyl betaine and glycerol is 600:150:40:5.

[0022] (3) Heat behenamidopropyl dimethylamine to 80°C to melt it into a liquid; mix pyrrolidone ethanolamine salt and glycerol to obtain a slurry; add the slurry to the mixed phase obtained in step (2), stir at 200 rpm for 10 minutes, then slowly add the melted behenamidopropyl dimethylamine over 5 minutes at 80°C and 200 rpm, stir at 800 rpm for 3 minutes, cool to 40°C, adjust the pH to 5.5 with 45% citric acid aqueous solution, then add 20% chlorhexidine gluconate aqueous solution, bis-PEG-15 methyl ether polydimethylsiloxane, lemon fragrance, phenoxyethanol preservative and deionized water in sequence at 40°C and 100 rpm, stir for 10 minutes after each material is added, then add sodium chloride, continue stirring for 20 minutes, cool to 30°C and discharge to obtain the antibacterial and anti-mite shampoo. The mass ratio of the mixed phase, piroctone ethanolamine salt, glycerol, behenamidopropyl dimethylamine, chlorhexidine gluconate aqueous solution, bis-PEG-15 methyl ether polydimethylsiloxane, lemon flavor, phenoxyethanol preservative, deionized water and sodium chloride is 800:0.5:4:5:10:3:0.5:0.5:5:5.

[0023] Example 2

[0024] (1) Add deionized water to the reactor, add disodium ethylenediaminetetraacetate and polyquaternium salt-10 at a stirring speed of 75 rpm, then heat to 77.5℃ and continue stirring for 35 minutes to obtain an aqueous phase; wherein the mass ratio of deionized water, disodium ethylenediaminetetraacetate and polyquaternium salt-10 is 675:0.2:1.5.

[0025] (2) Sodium lauryl ether sulfate, cocamidopropyl betaine and glycerol are mixed in a reactor and stirred at 200 rpm for 12.5 minutes at 25±5℃ to obtain a surfactant phase; the surfactant phase is slowly added to the aqueous phase obtained in step (1) at 77.5℃ within 12.5 minutes and stirred at 250 rpm. After the addition is completed, stirring is continued for 20 minutes to obtain a mixed phase; wherein the mass ratio of aqueous phase, sodium lauryl ether sulfate, cocamidopropyl betaine and glycerol is 650:165:50:7.5.

[0026] (3) Heat behenamidopropyl dimethylamine to 82.5°C to melt it into a liquid; mix piroctone ethanolamine salt and glycerol to obtain a slurry; add the slurry to the mixture obtained in step (2), stir at 250 rpm for 15 minutes, then slowly add the molten behenamidopropyl dimethylamine over 7.5 minutes at 82.5°C and 250 rpm, then stir at 1000 rpm for 4 minutes, and cool to 42.5°C. The pH was adjusted to 5.7 using a 50% citric acid aqueous solution. Then, under stirring at 42.5℃ and 150 rpm, a 25% chlorhexidine gluconate aqueous solution, bis-PEG-15 methyl ether polydimethylsiloxane, lemon fragrance, phenoxyethanol preservative, and deionized water were added sequentially. After each addition, the mixture was stirred for 15 minutes. Then, sodium chloride was added, and stirring continued for 25 minutes. After cooling to 35℃, the mixture was discharged to obtain the antibacterial and anti-mite shampoo. The mass ratio of the mixed phase, piroctone ketone ethanolamine salt, glycerin, behenamidopropyl dimethylamine, chlorhexidine gluconate aqueous solution, bis-PEG-15 methyl ether polydimethylsiloxane, lemon fragrance, phenoxyethanol preservative, deionized water, and sodium chloride was 850:0.75:5:6.5:15:4.5:1.25:0.75:10:10.

[0027] Example 3

[0028] (1) Add deionized water to the reactor, add disodium ethylenediaminetetraacetate and polyquaternium salt-10 at a stirring speed of 100 rpm, then heat to 80°C and continue stirring for 40 minutes to obtain an aqueous phase; wherein the mass ratio of deionized water, disodium ethylenediaminetetraacetate and polyquaternium salt-10 is 700:0.3:2.

[0029] (2) Sodium lauryl ether sulfate, cocamidopropyl betaine and glycerol are mixed in a reactor and stirred at 250 rpm for 15 minutes at 25±5℃ to obtain a surfactant phase; the surfactant phase is slowly added to the aqueous phase at 80℃ obtained in step (1) within 15 minutes and stirred at 300 rpm. After the addition is completed, stirring is continued for 25 minutes to obtain a mixed phase; wherein the mass ratio of aqueous phase, sodium lauryl ether sulfate, cocamidopropyl betaine and glycerol is 700:180:60:10.

[0030] (3) Heat behenamidopropyl dimethylamine to 85°C to melt it into a liquid; mix pyrrolidone ethanolamine salt and glycerol to obtain a slurry; add the slurry to the mixed phase obtained in step (2), stir at 300 rpm for 20 minutes, then slowly add the melted behenamidopropyl dimethylamine over 10 minutes at 85°C and 300 rpm, stir at 1200 rpm for 5 minutes, cool to 45°C, adjust the pH to 6.0 with 55% citric acid aqueous solution, then add 30% chlorhexidine gluconate aqueous solution, bis-PEG-15 methyl ether polydimethylsiloxane, lemon fragrance, phenoxyethanol preservative and deionized water in sequence at 45°C and 200 rpm, stir for 20 minutes after each material is added, then add sodium chloride, continue stirring for 30 minutes, cool to 40°C and discharge to obtain the antibacterial and anti-mite shampoo. The mass ratio of the mixed phase, piroctone ethanolamine salt, glycerol, behenamidopropyl dimethylamine, chlorhexidine gluconate aqueous solution, bis-PEG-15 methyl ether polydimethylsiloxane, lemon flavor, phenoxyethanol preservative, deionized water and sodium chloride is 900:1.0:6:8:20:6:2.0:1.0:15:15.

[0031] Comparative Example 1 The only difference between Comparative Example 1 and Example 1 is that the aqueous solution of chlorhexidine gluconate is omitted.

[0032] Comparative Example 2 The only difference between Comparative Example 2 and Example 1 is that behenamidopropyl dimethylamine is omitted.

[0033] Comparative Example 3 The only difference between Comparative Example 3 and Example 1 is that the pyrrolidone ethanolamine salt is omitted.

[0034] Antibacterial properties: tested according to QB / T2738-2023.

[0035] Acaricide performance: The sample was diluted 10-fold with 0.9% physiological saline. A groove was made on a glass slide using Vaseline, and 0.1 mL of the sample dilution was added. Twenty dust mites were transferred into the sample dilution using a capillary tube. A coverslip was then placed in an incubator at 25°C and 75% relative humidity for 24 hours. The number of dead mites was recorded under a microscope (complete immobility was considered the standard). This was repeated 10 times, and the acaricide rate was calculated.

[0036] Table 1 below shows the performance analysis results of the embodiments and comparative examples of the present invention.

[0037] Table 1

[0038] Experimental data from the examples and comparative examples show that the shampoo exhibits the best antibacterial and anti-mite effects only when the protonated behenamidopropyl dimethylamine, chlorhexidine gluconate, and piroctone ethanolamine salt are present simultaneously. The absence of any one of the components will lead to a significant decrease in performance.

[0039] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No markings in the claims should be construed as limiting the scope of the claims.

Claims

1. An antibacterial and anti-mite shampoo, characterized in that, The antibacterial and anti-mite shampoo is prepared from piroctone ethanolamine salt, glycerin, a mixed phase, behenamidopropyl dimethylamine, citric acid aqueous solution, chlorhexidine gluconate aqueous solution, bis-PEG-15 methyl ether polydimethylsiloxane, lemon fragrance, phenoxyethanol preservative, deionized water, and sodium chloride; the mixed phase is prepared from sodium lauryl ether sulfate, cocamidopropyl betaine, glycerin, and an aqueous phase; the aqueous phase is prepared from deionized water, disodium ethylenediaminetetraacetate, and polyquaternium-10.

2. The antibacterial and anti-mite shampoo according to claim 1, characterized in that... The mass fraction of citric acid in aqueous solution is 45-55%.

3. The antibacterial and anti-mite shampoo according to claim 1, characterized in that... The mass fraction of chlorhexidine gluconate aqueous solution is 20-30%.

4. A method for preparing an antibacterial and anti-mite shampoo, applicable to the antibacterial and anti-mite shampoo according to any one of claims 1-4, characterized in that, Includes the following steps: (1) Add deionized water to the reactor, add disodium ethylenediaminetetraacetate and polyquaternium-10 while stirring at 50-100 rpm, then heat to 75-80℃ and continue stirring for 30-40 minutes to obtain the aqueous phase; (2) Sodium lauryl ether sulfate, cocamidopropyl betaine and glycerol are mixed in a reactor and stirred at 150-250 rpm for 10-15 minutes at 25±5℃ to obtain a surfactant phase; the surfactant phase is slowly added to the aqueous phase obtained in step (1) at 75-80℃ and stirred at 200-300 rpm. After the addition is complete, stirring is continued for 15-25 minutes to obtain a mixed phase; (3) Heat behenamidopropyl dimethylamine to 80-85°C to melt it into a liquid; mix piroctone ethanolamine salt and glycerol to obtain a slurry; add the slurry to the mixed phase obtained in step (2), stir at 200-300 rpm for 10-20 minutes, then slowly add the molten behenamidopropyl dimethylamine over 5-10 minutes at 80-85°C and 200-300 rpm, and then stir at 800-1200 rpm for 3 minutes. After cooling to 40-45℃ for 5 minutes, adjust the pH value with citric acid aqueous solution. Then, at 40-45℃ and a stirring speed of 100-200 rpm, add chlorhexidine gluconate aqueous solution, bis-PEG-15 methyl ether polydimethylsiloxane, lemon fragrance, phenoxyethanol preservative and deionized water in sequence. Stir for 10-20 minutes after each material is added. Then add sodium chloride and continue stirring for 20-30 minutes. After cooling to 30-40℃, discharge the material to obtain the antibacterial and anti-mite shampoo.

5. The method for preparing an antibacterial and anti-mite shampoo according to claim 4, characterized in that... In step (1), the mass ratio of deionized water, disodium ethylenediaminetetraacetate, and polyquaternium-10 is 650-700:0.1-0.3:1-2.

6. The method for preparing an antibacterial and anti-mite shampoo according to claim 4, characterized in that... In step (2), the mass ratio of aqueous phase, sodium lauryl ether sulfate, cocamidopropyl betaine and glycerol is 600-700:150-180:40-60:5-10.

7. The method for preparing an antibacterial and anti-mite shampoo according to claim 4, characterized in that... In step (2), the surfactant phase is slowly added to the aqueous phase over 10-15 minutes.

8. The method for preparing an antibacterial and anti-mite shampoo according to claim 4, characterized in that... In step (3), the mass ratio of the mixed phase, pyrrolidone ethanolamine salt, glycerol, behenamidopropyl dimethylamine, chlorhexidine gluconate aqueous solution, bis-PEG-15 methyl ether polydimethylsiloxane, lemon flavor, phenoxyethanol preservative, deionized water and sodium chloride is 800-900:0.5-1.0:4-6:5-8:10-20:3-6:0.5-2.0:0.5-1.0:5-15:5-15.

9. The method for preparing an antibacterial and anti-mite shampoo according to claim 4, characterized in that... In step (3), the pH value is adjusted to 5.5-6.0 using citric acid aqueous solution.

10. The method for preparing an antibacterial and anti-mite shampoo according to claim 1, characterized in that... In step (3), the methyl methacrylate is preheated to melt into a liquid.

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