Optical chip for exciting fluorescence signal and fluorescence detection method

By introducing a fluorescence excitation structure and a polarization rotation reflection module into the optical chip, and using 90-degree polarization rotation excitation light and superimposing the excitation light, the problems of limited room for improvement of fluorescence signal-to-noise ratio and high power consumption in biochip technology are solved, thereby achieving improved signal-to-noise ratio and enhanced integration.

CN122084585APending Publication Date: 2026-05-26PHOTONIC VIEW TECHNOLOGY CO LTD
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Patent Information

Application Number
CN202610317081.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-16
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing biochip technologies suffer from limited room for improvement in fluorescence signal-to-noise ratio and high power consumption.

Method used

By introducing a fluorescent excitation structure, a polarization rotation reflection module, and a substrate into the optical chip, and utilizing a transmission waveguide and a sample well unit, the excitation light is excited by a 90-degree polarization rotation and superimposed in the transmission waveguide, thereby increasing the excitation light intensity without increasing the chip power consumption.

Benefits of technology

Without increasing chip power consumption, the signal-to-noise ratio of the fluorescent signal is improved, and the integration of the optical chip is enhanced, making it suitable for industrial production.

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Abstract

The invention provides an optical chip for exciting a fluorescence signal. The optical chip comprises a fluorescence excitation structure, a polarization rotation reflection module and a substrate, the fluorescence excitation structure is formed on the substrate and comprises a transmission waveguide and a sample well, and the transmission waveguide outputs first excitation light to the polarization rotation reflection module; the polarization rotation reflection module is used for performing 90-degree polarization rotation on the first excitation light to generate second excitation light and transmitting the second excitation light to the transmission waveguide. The invention also provides a fluorescence detection method which comprises the following steps: emitting first exciting light to the transmission waveguide, and arranging a sample in an evanescent field of light transmitted by the transmission waveguide; performing 90-degree polarization rotation on the first exciting light to generate second exciting light, and transmitting the second exciting light back to the transmission waveguide; and detecting a fluorescence signal excited by the sample in the sample well based on the first excitation light and the second excitation light. Therefore, two kinds of exciting light with mutually orthogonal polarization states are superposed, and the signal-to-noise ratio of a fluorescence signal is improved under the condition that standing waves are not generated.
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