Novel compounds and uses thereof
By binding a novel compound to the Cereblon protein, the ubiquitination and degradation of the GSPT1 protein are promoted, which solves the problem that existing technologies cannot effectively target and inhibit GSPT1, and provides an effective GSPT1 degrader for the treatment of proliferative diseases.
CN122249432APending Publication Date: 2026-06-19PUTEL BIOTECHNOLOGY CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- PUTEL BIOTECHNOLOGY CO LTD
- Filing Date
- 2024-11-20
- Publication Date
- 2026-06-19
Smart Images
Figure CN122249432A_ABST
Abstract
This invention relates to a novel compound and its uses. The novel compound, its isomers, its pharmaceutically acceptable salts, or its solvates have excellent binding affinity to Cerebrolysin, and therefore can effectively degrade GSPT1 through the E3 ubiquitin ligase activity of the Cerebrolysin complex, thereby enabling effective treatment of diseases including proliferative disorders.
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