Femtosecond-nanosecond laser system and method for preparing multi-size drug-loaded structure vascular stent

Abstract

This invention discloses a femtosecond and nanosecond laser fabrication system and method for multi-size drug-loaded vascular stents, relating to the field of medical device manufacturing technology. The multi-size drug-loaded vascular stent femtosecond and nanosecond laser fabrication system includes: a processing platform; a main optical path assembly; a nanosecond laser, the laser emitted by the nanosecond laser being adapted to process drug-loaded grooves on the vascular stent; a femtosecond laser, the laser emitted by the femtosecond laser being adapted to process drug-loaded blind holes on the vascular stent; and an optical path switching device, which in a first state is adapted to guide the laser emitted by the nanosecond laser to the main optical path assembly, and in a second state is adapted to guide the laser emitted by the femtosecond laser to the main optical path assembly. The multi-size drug-loaded vascular stent femtosecond and nanosecond laser fabrication system according to embodiments of this invention can process multi-size drug-loaded structures, facilitating the meeting of rapid and sustained drug release requirements, and has advantages such as high reliability and high processing efficiency.

Description

Technical Field

[0001] This invention relates to the field of medical device manufacturing technology, and more specifically, to a femtosecond and nanosecond laser fabrication system and method for multi-size drug-loaded vascular stents. Background Technology

[0002] Vascular stents are important medical devices used in cardiovascular interventional procedures to support narrowed or occluded blood vessels and maintain vascular patency.

[0003] Drug-eluting stents inhibit stent intimal hyperplasia through local drug delivery, which can significantly reduce the risk of in-stent restenosis.

[0004] Drug-loaded vascular stents in related technologies use drug-loaded grooves on the surface of the stent to accommodate crystalline drugs. However, due to limitations in processing equipment, only simple and single-function drug-loaded grooves can be processed, which can only achieve drug release at a specific rate. A slow release rate will result in the local drug concentration peak being difficult to reach the requirement of preventing new intimal hyperplasia in a short period of time, while a fast release rate will result in insufficient local drug activity in the future. Summary of the Invention

[0005] This invention aims to at least solve one of the technical problems existing in the prior art. To this end, this invention proposes a femtosecond and nanosecond laser fabrication system for multi-size drug-loaded vascular stents. This system can process multi-size drug-loaded structures, facilitating the meeting of requirements for rapid and sustained drug release, and has advantages such as high reliability and high processing efficiency.

[0006] This invention also proposes a femtosecond and nanosecond laser fabrication method for multi-size drug-loaded vascular stents.

[0007] To achieve the above objectives, according to an embodiment of the first aspect of the present invention, a femtosecond and nanosecond laser fabrication system for multi-size drug-loaded vascular stents is provided. The system includes: a processing platform adapted to place a vascular stent; a main optical path assembly adapted to guide a laser beam to the vascular stent; a nanosecond laser whose emitted laser beam is adapted to fabricate drug-loaded grooves on the vascular stent; a femtosecond laser whose emitted laser beam is adapted to fabricate drug-loaded blind holes on the vascular stent, wherein the cross-sectional area of ​​the drug-loaded blind holes perpendicular to the depth direction is smaller than the cross-sectional area of ​​the drug-loaded grooves perpendicular to the depth direction; and an optical path switching device switchable between a first state and a second state. In the first state, the optical path switching device is adapted to guide the laser beam emitted by the nanosecond laser to the main optical path assembly, and in the second state, the optical path switching device is adapted to guide the laser beam emitted by the femtosecond laser to the main optical path assembly.

[0008] The femtosecond and nanosecond laser fabrication system for multi-size drug-loaded vascular stents according to embodiments of the present invention can process multi-size drug-loaded structures, which can easily meet the requirements for rapid and sustained drug release, and has the advantages of high reliability and high processing efficiency.

[0009] In addition, the femtosecond and nanosecond laser fabrication system for multi-size drug-loaded vascular stents according to the above embodiments of the present invention may also have the following additional technical features: According to one embodiment of the present invention, the optical path switching device includes: a switching mirror, the switching mirror being rotatable between a first position and a second position, the switching mirror being adapted, when in the first position, to reflect laser light emitted by the nanosecond laser to the main optical path assembly, and the switching mirror being adapted, when in the second position, to reflect laser light emitted by the femtosecond laser to the main optical path assembly; and a mirror driving device, the mirror driving device being drively connected to the switching mirror to drive the switching mirror to rotate between the first position and the second position.

[0010] According to one embodiment of the present invention, the main optical path assembly includes: an objective lens adapted to focus the laser onto the vascular stent, and the laser emitted by the optical path switching device adapted to irradiate the vascular stent through the objective lens.

[0011] According to one embodiment of the present invention, the main optical path assembly further includes: a corrective lens, the corrective lens being adapted to correct the laser, and the laser emitted by the optical path switching device being adapted to sequentially pass through the corrective lens and the objective lens to irradiate the vascular stent.

[0012] According to one embodiment of the present invention, the main optical path assembly further includes: an aperture, the aperture being adapted to adjust the spot size of the laser, and the laser emitted by the optical path switching device being adapted to sequentially pass through the corrective lens, the aperture, and the objective lens to irradiate the vascular stent.

[0013] According to one embodiment of the present invention, the main optical path assembly further includes an optical path reflector adapted to reflect the laser emitted from the aperture to the objective lens.

[0014] According to one embodiment of the present invention, the processing platform is a six-axis moving platform, which is adapted to move the vascular stent placed on the processing platform.

[0015] According to one embodiment of the present invention, the femtosecond and nanosecond laser fabrication system for multi-size drug-loaded vascular stents includes: a nanosecond shutter disposed between the nanosecond laser and the optical path switching device; and a femtosecond shutter disposed between the femtosecond laser and the optical path switching device.

[0016] According to one embodiment of the present invention, the drug-loaded blind hole is formed on the bottom wall of the drug-loaded groove.

[0017] According to a second aspect of the present invention, a method for fabricating multi-size drug-loaded vascular stents using femtosecond and nanosecond lasers is provided. The method employs the multi-size drug-loaded vascular stent femtosecond and nanosecond laser fabrication system described in a first aspect of the present invention, and includes the following steps: When the femtosecond laser is turned off, the optical path switching device switches to the first state and turns on the nanosecond laser. The laser emitted by the nanosecond laser is guided by the optical path switching device and the main optical path assembly to the vascular stent on the processing platform, and a drug-loaded groove is processed on the vascular stent. After the drug-loaded groove is processed, the nanosecond laser is turned off; The optical path switching device switches to the second state, turns on the femtosecond laser, and the laser emitted by the femtosecond laser is guided by the optical path switching device and the main optical path assembly to the vascular stent on the processing platform, where drug-loaded blind holes are processed on the vascular stent. After the drug-loaded blind hole is processed, the femtosecond laser is turned off.

[0018] The femtosecond and nanosecond laser fabrication method for multi-size drug-loaded vascular stents according to embodiments of the present invention, by utilizing the femtosecond and nanosecond laser fabrication system for multi-size drug-loaded vascular stents according to the first aspect of the present invention, can process multi-size drug-loaded structures, which can easily meet the requirements for rapid and sustained drug release, and has the advantages of high reliability and high processing efficiency.

[0019] Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0020] The above and / or additional aspects and advantages of the present invention will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which: Figure 1 This is a schematic diagram of a femtosecond and nanosecond laser fabrication system for multi-size drug-loaded vascular stents according to an embodiment of the present invention, wherein the optical path switching device is in the first state.

[0021] Figure 2 This is a schematic diagram of a femtosecond and nanosecond laser fabrication system for multi-size drug-loaded vascular stents according to an embodiment of the present invention, wherein the optical path switching device is in the second state.

[0022] Figure 3This is a schematic diagram of the process for fabricating multi-size drug-loaded vascular stents using femtosecond and nanosecond lasers according to an embodiment of the present invention.

[0023] Figure 4 This is a flowchart of a femtosecond and nanosecond laser fabrication method for multi-size drug-loaded vascular stents according to an embodiment of the present invention.

[0024] Figure reference numerals: Multi-size drug-loaded vascular stent femtosecond and nanosecond laser fabrication system 1, processing platform 10, objective lens 21, corrective lens 22, aperture 23, optical path reflector 24, nanosecond laser 30, femtosecond laser 40, optical path switching device 50, nanosecond shutter 60, femtosecond shutter 70, controller 80, vascular stent 2, drug-loaded groove 3, drug-loaded blind hole 4. Detailed Implementation

[0025] This application is based on the findings and understanding of the following facts and issues: Drug-loaded vascular stents in related technologies use drug-loaded grooves on the surface of the stent to accommodate crystalline drugs. However, due to limitations in processing equipment, only simple and single-function drug-loaded grooves can be processed, which can only achieve drug release at a specific rate. A slow release rate will result in the local drug concentration peak being difficult to reach the requirement of preventing new intimal hyperplasia in a short period of time, while a fast release rate will result in insufficient local drug activity in the future.

[0026] Specifically, in the clinical treatment of vascular occlusion, releasing the drug within a relatively short period of time helps to ensure that the local peak drug concentration reaches the treatment requirements as soon as possible and prevents new intimal hyperplasia, while the subsequent slow release of the drug can ensure the long-term local activity of the drug.

[0027] In related technologies, vascular stents are limited by processing equipment and can only be processed into drug-loaded grooves with simple structures and single functions. Drugs can only be released at a linear rate according to the simple groove structure. Due to the limited size of the stent itself, the simple groove is structurally limited and cannot meet the requirements of continuous release while ensuring rapid drug release.

[0028] Embodiments of the present invention are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention.

[0029] In the description of this invention, it should be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," and "circumferential," etc., indicating orientation or positional relationships, are based on the orientation or positional relationships shown in the accompanying drawings and are only for the convenience of describing the invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the invention. Furthermore, features defined with "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this invention, unless otherwise stated, "a plurality of" means two or more. In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0030] The following description, with reference to the accompanying drawings, describes a femtosecond and nanosecond laser fabrication system 1 for multi-size drug-loaded vascular stents according to an embodiment of the present invention.

[0031] like Figures 1-4 As shown, the femtosecond and nanosecond laser fabrication system 1 for multi-size drug-loaded vascular stents according to an embodiment of the present invention includes a processing platform 10, a main optical path assembly, a nanosecond laser 30, a femtosecond laser 40, and an optical path switching device 50.

[0032] The processing platform 10 is adapted to place the vascular stent 2. The main optical path assembly is adapted to guide the laser to the vascular stent 2. The laser emitted by the nanosecond laser 30 is adapted to process the drug-loaded groove 3 on the vascular stent 2. The laser emitted by the femtosecond laser 40 is adapted to process the drug-loaded blind hole 4 on the vascular stent 2, the cross-sectional area of ​​the drug-loaded blind hole 4 perpendicular to the depth direction being smaller than the cross-sectional area of ​​the drug-loaded groove 3 perpendicular to the depth direction. The optical path switching device 50 is switchable between a first state and a second state. In the first state, the optical path switching device 50 is adapted to guide the laser emitted by the nanosecond laser 30 to the main optical path assembly, and in the second state, the optical path switching device 50 is adapted to guide the laser emitted by the femtosecond laser 40 to the main optical path assembly.

[0033] Specifically, the multi-size drug-loaded vascular stent femtosecond and nanosecond laser fabrication system 1 also includes a controller 80, which can be a computer. The controller 80 is electrically connected to the processing platform 10, the nanosecond laser 30, the femtosecond laser 40, and the optical path switching device 50, respectively. The controller 80 can adjust the power and repetition rate of the nanosecond laser 30 and the femtosecond laser 40.

[0034] The following is for reference. Figures 1-4 The fabrication process of the femtosecond and nanosecond laser fabrication system 1 for multi-size drug-loaded vascular stents according to an embodiment of the present invention is described.

[0035] The femtosecond laser 40 is turned off, the optical path switching device 50 is switched to the first state, and the nanosecond laser 30 is turned on. The laser emitted by the nanosecond laser 30 is guided by the optical path switching device 50 and the main optical path assembly to the vascular stent 2 on the processing platform 10, where a drug-loaded groove 3 is processed. After the drug-loaded groove 3 is processed, the nanosecond laser 30 is turned off. The optical path switching device 50 is switched to the second state, and the femtosecond laser 40 is turned on. The laser emitted by the femtosecond laser 40 is guided by the optical path switching device 50 and the main optical path assembly to the vascular stent 2 on the processing platform 10, where a drug-loaded blind hole 4 is processed. After the drug-loaded blind hole 4 is processed, the femtosecond laser 40 is turned off.

[0036] Specifically, the vascular stent 2 can be a mesh structure or a corrugated structure, and can be made of metal, ceramic, or polymer materials. The drug-loading groove 3 can be one or more of the following: cylindrical groove, elliptical cylindrical groove, and rectangular groove.

[0037] The vascular stent 2 can be used to crystallize and store drugs in the drug-loaded groove 3 and the drug-loaded blind hole 4 by solution crystallization.

[0038] After the vascular stent 2 is implanted into the blood vessel, the crystalline drug in the drug-loaded groove 3 and the drug-loaded blind hole 4 begins to be released. Because the drug-loaded groove 3 has a relatively larger size, the crystalline drug can be released quickly, and the drug concentration can reach its peak quickly. Because the drug-loaded blind hole 4 has a relatively smaller size, the crystalline drug can be released slowly and continuously, and the drug can maintain long-term local activity.

[0039] According to the embodiment of the present invention, the femtosecond and nanosecond laser fabrication system 1 for multi-size drug-loaded vascular stents can use a nanosecond laser 30 to process larger-sized drug-loaded grooves 3, ensuring sufficient drug loading in the vascular stent 2, facilitating rapid drug release in a short time, and quickly meeting the drug concentration treatment requirements. Moreover, by using a femtosecond laser 40, smaller-sized drug-loaded blind holes 4 can be processed, enabling long-term continuous drug release and ensuring the continuity of drug supply to the vascular stent 2.

[0040] Furthermore, by setting up an optical path switching device 50, which can switch between a first state and a second state, the optical path switching device 50 can guide the laser emitted by the nanosecond laser 30 to the main optical path component in the first state, thereby using the nanosecond laser emitted by the nanosecond laser 30 to process the vascular stent 2. Similarly, the optical path switching device 50 can guide the laser emitted by the femtosecond laser 40 to the main optical path component in the second state, thereby using the femtosecond laser emitted by the femtosecond laser 40 to process the vascular stent 2. Thus, by switching the optical path switching device 50, drug-loaded grooves 3 and drug-loaded blind holes 4 can be processed on the vascular stent 2 respectively, enabling the multi-size drug-loaded structure vascular stent femtosecond nanosecond laser fabrication system 1 to process multi-size drug-loaded structures. Compared with related vascular stent processing equipment, this system overcomes processing technology limitations, allowing the fabrication of drug-loaded grooves 3 and drug-loaded blind holes 4 of different sizes on the vascular stent 2 to form multi-size drug-loaded structures, meeting the requirements for rapid and sustained drug release.

[0041] Furthermore, since the optical paths of the nanosecond laser 30 and the femtosecond laser 40 can be switched by the optical path switching device 50, after one of the nanosecond laser 30 and the femtosecond laser 40 has been processed, it can be switched to the other by the optical path switching device 50 without moving the vascular stent 2. This enables continuous in-situ processing of the vascular stent 2, improves processing efficiency, and avoids affecting processing accuracy and improves processing reliability by moving the vascular stent 2.

[0042] Therefore, the femtosecond and nanosecond laser fabrication system 1 for multi-size drug-loaded vascular stents according to the present invention can process multi-size drug-loaded structures, which can meet the requirements for rapid and sustained drug release and has the advantages of high reliability and high processing efficiency.

[0043] The following description, with reference to the accompanying drawings, describes a femtosecond and nanosecond laser fabrication system for multi-size drug-loaded vascular stents according to a specific embodiment of the present invention.

[0044] In some specific embodiments of the present invention, such as Figures 1-4 As shown, the femtosecond and nanosecond laser fabrication system 1 for multi-size drug-loaded vascular stents according to an embodiment of the present invention includes a processing platform 10, a main optical path assembly, a nanosecond laser 30, a femtosecond laser 40, and an optical path switching device 50.

[0045] Specifically, such as Figure 1 and Figure 2As shown, the optical path switching device 50 includes a switching mirror and a mirror driving device. The switching mirror is rotatable between a first position and a second position. When in the first position, the switching mirror is adapted to reflect the laser emitted from the nanosecond laser 30 to the main optical path assembly. When in the second position, the switching mirror is adapted to reflect the laser emitted from the femtosecond laser 40 to the main optical path assembly. The mirror driving device is driven by the switching mirror to drive the switching mirror to rotate between the first position and the second position. In this way, the optical path can be switched by driving the switching mirror to rotate.

[0046] More specifically, such as Figure 1 and Figure 2 As shown, the main optical path assembly includes an objective lens 21, which is adapted to focus the laser onto the vascular stent 2. The laser emitted from the optical path switching device 50 is adapted to irradiate the vascular stent 2 through the objective lens 21. This facilitates the focusing of the laser onto the vascular stent 2 for processing.

[0047] Advantageously, such as Figure 1 and Figure 2 As shown, the main optical path assembly also includes a corrective lens 22, which is adapted to correct the laser beam. The laser beam emitted from the optical path switching device 50 is adapted to pass through the corrective lens 22 and the objective lens 21 in sequence to irradiate the vascular stent 2. In this way, the corrective lens 22 can be used to correct the laser beam emitted from the optical path switching device 50, avoiding angular errors in the laser beam emitted from the optical path switching device 50 that could affect the processing accuracy.

[0048] More advantageously, such as Figure 1 and Figure 2 As shown, the main optical path assembly also includes an aperture 23, which is adapted to adjust the size of the laser spot. The laser emitted from the optical path switching device 50 is adapted to sequentially pass through the corrective lens 22, the aperture 23, and the objective lens 21 to irradiate the vascular stent 2. This facilitates the adjustment of the laser spot size, thereby facilitating the control of the processing.

[0049] Furthermore, such as Figure 1 and Figure 2 As shown, the main optical path assembly also includes an optical path reflector 24, which is adapted to reflect the laser emitted from the aperture 23 to the objective lens 21. In other words, the laser emitted from the optical path switching device 50 passes sequentially through the corrective lens 22, the aperture 23, the optical path reflector 24, and the objective lens 21 before irradiating the vascular stent 2 for processing. This facilitates changing the direction of the laser and makes the configuration of the objective lens 21 and the aperture 23 more flexible.

[0050] In some embodiments, the processing platform 10 is a six-axis moving platform, adapted to move the vascular stent 2 placed on the processing platform 10. Specifically, the controller 80 can control the movement speed, tilt angle, and starting position of the six-axis moving platform, thereby controlling the laser processing range and the overlap rate of the laser scanning path. In this way, the movement of the processing platform 10 can drive the movement of the vascular stent 2, causing the vascular stent 2 to move relative to the light spot emitted from the objective lens 21, thereby controlling the processing process and facilitating the fabrication of the required structure on the vascular stent 2.

[0051] Figure 1 and Figure 2 A femtosecond and nanosecond laser fabrication system for multi-size drug-loaded vascular stents according to some examples of the present invention is shown. For example... Figure 1 and Figure 2 As shown, the femtosecond and nanosecond laser fabrication system 1 for multi-size drug-loaded vascular stents also includes a nanosecond shutter 60 and a femtosecond shutter 70. The nanosecond shutter 60 is located between the nanosecond laser 30 and the optical path switching device 50. The femtosecond shutter 70 is located between the femtosecond laser 40 and the optical path switching device 50. Specifically, the controller 80 can control the opening and closing of the nanosecond shutter 60 and the femtosecond shutter 70. For example, the femtosecond shutter 70 can control the time interval for the femtosecond laser to process the drug-loaded blind hole 4. In this way, the nanosecond shutter 60 and the femtosecond shutter 70 can be used to control whether the nanosecond and femtosecond lasers can pass through, thereby controlling the processing steps.

[0052] Specifically, such as Figure 3 As shown, the drug-loaded blind hole 4 is formed on the bottom wall of the drug-loaded groove 3. It is important to understand that the bottom wall of the drug-loaded groove 3 refers to the surface opposite the open surface of the drug-loaded groove 3. In other words, the bottom wall of the drug-loaded groove 3 refers to the surface opposite the surface of the drug-loaded groove 3 on the vascular stent. It is important to understand that... Figure 3 The structure of the drug-loaded groove 3 shown is a cross-sectional view. This allows the crystalline drug in the drug-loaded blind hole 4 to begin releasing after the crystalline drug in the drug-loaded groove 3 has been completely released, which can further increase the drug release time and facilitate the long-term maintenance of drug activity.

[0053] The following is for reference. Figures 1-4 The working process of the femtosecond and nanosecond laser fabrication system 1 for multi-size drug-loaded vascular stents according to an embodiment of the present invention is described.

[0054] Keeping the femtosecond laser 40 and femtosecond shutter 70 closed, rotate the switching mirror to the first position. Set the power and repetition frequency of the nanosecond laser 30 via controller 80; set the movement speed, tilt angle, and starting position of the processing platform 10 via controller 80. Turn on the nanosecond laser 30 and nanosecond shutter 60. The nanosecond laser emitted by the nanosecond laser 30 passes through the nanosecond shutter 60 and is reflected by the switching mirror to the main optical path assembly. After being corrected by the corrective lenses 22, the spot size is controlled by the aperture 23, and the light is reflected by the optical path mirror 24 to the objective lens 21. The objective lens 21 focuses the light onto the vascular stent 2 placed on the processing platform 10 to process the drug-loaded groove 3. After completing the processing of the drug-loaded groove 3, turn off the nanosecond laser 30 and nanosecond shutter 60.

[0055] The controller 80 sets the power and repetition frequency of the femtosecond laser 40; it also sets the movement speed, tilt angle, and starting position of the processing platform 10; and it sets the opening and closing time of the femtosecond shutter 70. Rotating the switching mirror to the second position opens the femtosecond laser 40, and the femtosecond shutter 70 operates at the set opening and closing times. The femtosecond laser emitted by the femtosecond laser 40 passes through the femtosecond shutter 70, is reflected by the switching mirror to the main optical path assembly, corrected by the correcting lens 22, and then the spot size is controlled by the aperture 23. The light is then reflected by the optical path mirror 24 to the objective lens 21, and focused onto the vascular stent 2 placed on the processing platform 10. Drug-loaded blind holes 4 are then processed on the bottom wall of the drug-loaded groove 3. After the drug-loaded blind holes 4 are processed, the femtosecond laser 40 and femtosecond shutter 70 are closed. The following describes a femtosecond and nanosecond laser fabrication method for multi-size drug-loaded vascular stents according to embodiments of the present invention. The femtosecond and nanosecond laser fabrication method for multi-size drug-loaded vascular stents according to embodiments of the present invention employs the femtosecond and nanosecond laser fabrication system 1 for multi-size drug-loaded vascular stents according to the above embodiments of the present invention, and includes the following steps: When the femtosecond laser is turned off, the optical path switching device switches to the first state and turns on the nanosecond laser. The laser emitted by the nanosecond laser is guided by the optical path switching device and the main optical path assembly to the vascular stent on the processing platform, and a drug-loaded groove is processed on the vascular stent. After the drug-loaded groove is processed, the nanosecond laser is turned off; The optical path switching device switches to the second state, turns on the femtosecond laser, and the laser emitted by the femtosecond laser is guided by the optical path switching device and the main optical path assembly to the vascular stent on the processing platform, where drug-loaded blind holes are processed on the vascular stent. After the drug-loaded blind hole is processed, the femtosecond laser is turned off.

[0056] The femtosecond and nanosecond laser fabrication method for multi-size drug-loaded vascular stents according to embodiments of the present invention, by utilizing the femtosecond and nanosecond laser fabrication system 1 for multi-size drug-loaded vascular stents according to the above embodiments of the present invention, can process multi-size drug-loaded structures, which can easily meet the requirements for rapid and sustained drug release, and has the advantages of high reliability and high processing efficiency.

[0057] Other components and operations of the multi-size drug-loaded vascular stent femtosecond and nanosecond laser fabrication system 1 and method according to embodiments of the present invention are known to those skilled in the art and will not be described in detail here.

[0058] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0059] Although embodiments of the invention have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.

Claims

1. A multi-size drug-loaded structure vascular stent femtosecond-nanosecond laser preparation system, characterized in that, include: A processing platform, wherein the processing platform is adapted to place vascular stents; A main optical path assembly, the main optical path assembly being adapted to guide a laser to the vascular stent; A nanosecond laser, wherein the laser emitted by the nanosecond laser is adapted to process drug-loaded grooves on the vascular stent; A femtosecond laser, wherein the laser emitted by the femtosecond laser is suitable for processing drug-loaded blind holes on the vascular stent, wherein the cross-sectional area of ​​the drug-loaded blind hole perpendicular to the depth direction is smaller than the cross-sectional area of ​​the drug-loaded groove perpendicular to the depth direction. An optical path switching device is available, which can be switched between a first state and a second state. In the first state, the optical path switching device is adapted to guide the laser emitted by the nanosecond laser to the main optical path component, and in the second state, the optical path switching device is adapted to guide the laser emitted by the femtosecond laser to the main optical path component.

2. The multi-size drug-loaded structure stent femtosecond-nanosecond laser fabrication system according to claim 1, wherein, The optical path switching device includes: A switching mirror is configured to rotate between a first position and a second position. When the switching mirror is in the first position, it is adapted to reflect the laser emitted by the nanosecond laser to the main optical path assembly. When the switching mirror is in the second position, it is adapted to reflect the laser emitted by the femtosecond laser to the main optical path assembly. A mirror driving device is connected to the switching mirror to drive the switching mirror to rotate between the first position and the second position.

3. The multi-size drug-loaded structure stent femtosecond-nanosecond laser fabrication system according to claim 1, wherein, The main optical path component includes: An objective lens, wherein the objective lens is adapted to focus the laser onto the vascular stent, and the laser emitted from the optical path switching device is adapted to irradiate the vascular stent through the objective lens.

4. The multi-size drug-loaded structure stent femtosecond-nanosecond laser fabrication system according to claim 3, wherein, The main optical path component also includes: A corrective lens is provided, which is adapted to correct the laser beam. The laser beam emitted by the optical path switching device is adapted to pass through the corrective lens and the objective lens in sequence to irradiate the vascular stent.

5. The multi-size drug-loaded structure stent femtosecond-nanosecond laser fabrication system according to claim 4, wherein, The main optical path component also includes: An aperture is provided, which is adapted to adjust the size of the laser spot. The laser emitted by the optical path switching device is adapted to irradiate the vascular stent by passing sequentially through the corrective lens, the aperture, and the objective lens.

6. The multi-size drug-loaded structure stent femtosecond-nanosecond laser fabrication system according to claim 5, wherein, The main optical path component also includes: An optical path reflector, which is adapted to reflect the laser emitted from the aperture to the objective lens.

7. The multi-size drug loaded structure stent femtosecond-nanosecond laser fabrication system according to claim 1, wherein, The processing platform is a six-axis moving platform, which is adapted to move the vascular stent placed on the processing platform.

8. The multi-size drug loaded structure stent femtosecond-nanosecond laser fabrication system according to claim 1, wherein, Also includes: A nanosecond shutter, wherein the nanosecond shutter is disposed between the nanosecond laser and the optical path switching device; A femtosecond shutter is located between the femtosecond laser and the optical path switching device.

9. The femtosecond and nanosecond laser fabrication system for multi-size drug-loaded vascular stents according to claim 1, characterized in that, The drug-loading blind hole is formed on the bottom wall of the drug-loading groove.

10. A method for fabricating multi-size drug-loaded vascular stents using femtosecond and nanosecond lasers, characterized in that, The femtosecond and nanosecond laser fabrication system for multi-size drug-loaded vascular stents according to any one of claims 1-9 includes the following steps: When the femtosecond laser is turned off, the optical path switching device switches to the first state and turns on the nanosecond laser. The laser emitted by the nanosecond laser is guided by the optical path switching device and the main optical path assembly to the vascular stent on the processing platform, and a drug-loaded groove is processed on the vascular stent. After the drug-loaded groove is processed, the nanosecond laser is turned off; The optical path switching device switches to the second state, turns on the femtosecond laser, and the laser emitted by the femtosecond laser is guided by the optical path switching device and the main optical path assembly to the vascular stent on the processing platform, where drug-loaded blind holes are processed on the vascular stent. After the drug-loaded blind hole is processed, the femtosecond laser is turned off.

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