Long-acting cool feeling wet tissue compound liquid and preparation method thereof

Abstract

The present application relates to the technical field of sanitary products, and provides a long-acting cool feeling wet wipe compound liquid and a preparation method thereof, which comprises: a cool feeling component, the cool feeling component comprising a long-acting cool feeling agent and an instantaneous cool feeling agent; a humectant, the humectant comprising a polyhydric alcohol; a conditioning stable composition, the conditioning stable composition comprising a zinc salt astringent, a chelating agent and a polyhydroxyl lactone pH buffer, which is used for buffering the acidity and alkalinity of the system and maintaining the compatibility of the components; a composite preservative and bacteriostatic system, the composite preservative and bacteriostatic system comprising an organic acid salt preservative, a biguanide polymer preservative, a phenolic ether preservative and an antistatic agent, which is used for providing broad-spectrum bacteriostatic action; and an alcohol-containing aqueous phase solvent, the alcohol-containing aqueous phase solvent serving as a dispersion medium; wherein the components form a multi-effect compatible system in the alcohol-containing aqueous phase solvent. The present application solves the problems of poor compatibility of multi-effect components and pH drift in the alcohol-containing system, realizes long-term stable coexistence of the cool feeling, preservative and conditioning components, and has excellent physicochemical stability and broad-spectrum bacteriostatic efficiency.

Description

Technical Field

[0001] This invention relates to the field of hygiene products technology, and in particular to a long-lasting cooling wipe compound solution and its preparation method. Background Technology

[0002] Cooling wipes, as an important functional hygiene product for summer cooling, post-exercise cleaning, and outdoor refreshment, rely on the activation of skin's cold receptors by cooling components for their core experience. In existing technologies, to balance the duration and gentleness of the cooling sensation, several solutions have been proposed using a combination of multiple cooling agents. Chinese patent application number 202511975060.X discloses a long-lasting cooling wipe compound liquid, which synergistically combines natural menthol, menthyl lactate, and methyl diisopropyl propionamide, along with an alcohol-free formula and plant-derived soothing ingredients, aiming to achieve a balance between instantaneous and long-lasting cooling sensation while reducing irritation.

[0003] However, the aforementioned existing technologies employ alcohol-free systems. While this avoids the risks of skin dryness and irritation associated with alcohol, it sacrifices the unique advantages of ethanol as a solvent in enhancing the cooling sensation, promoting the penetration of active ingredients, and assisting in antibacterial activity. In practical applications, alcohol-containing cooling wipes still enjoy widespread market demand due to their more significant refreshing sensation and quick-drying properties. However, the complexity of the system increases significantly when long-lasting cooling agents, multiple preservatives and antibacterial agents, and skin conditioning agents are introduced into an alcohol-containing aqueous system. The presence of ethanol easily alters the dielectric constant and solubility parameters of the solution, leading to antagonism or precipitation between preservatives with different chemical properties (such as organic acid salts, biguanides, and cationic bactericides). It also causes pH shifts in the system, resulting in product turbidity, stratification, or decreased antibacterial efficacy. Therefore, how to achieve compatible formulations of multiple components providing cooling sensation, preservative and antibacterial properties, and conditioning stability in an alcohol-containing aqueous environment, while ensuring the physicochemical stability and long-lasting efficacy of the system, is a pressing technical problem to be solved in this field. Summary of the Invention

[0004] The purpose of this invention is to provide a long-lasting cooling wipe compound solution and its preparation method, addressing the problems of poor compatibility of multi-effect components, easy turbidity, and insufficient pH stability in existing alcohol-containing cooling wipe compound solutions.

[0005] The above-mentioned technical objective of the present invention is achieved through the following technical solution: A long-lasting cooling wipe compound solution includes: Cooling components, wherein the cooling components include long-lasting cooling agents and instant cooling agents; Moisturizers, including polyols; A conditioning and stabilizing composition comprising a zinc salt astringent, a chelating agent, and a polyhydroxy lactone pH buffer, for buffering the acidity and alkalinity of the system and maintaining component compatibility; A composite preservative and antibacterial system, comprising organic acid salt preservatives, biguanide polymer preservatives, phenolic ether preservatives, and antistatic agents, for providing broad-spectrum antibacterial effects; And an alcohol-containing aqueous solvent, which serves as the dispersion medium for the cooling component, the conditioning and stabilizing composition, and the composite preservative and antibacterial system; The conditioning and stabilizing composition, the composite antiseptic and antibacterial system, and the cooling component form a multi-functional and compatible system in the alcohol-containing aqueous solvent.

[0006] Preferably, based on the total weight of the compound solution for wet wipes, the zinc salt astringent has a weight percentage of 0.05%-0.3%, the polyhydroxy lactone pH buffer has a weight percentage of 0.05%-0.3%, and the chelating agent has a weight percentage of 0.01%-0.2%.

[0007] Preferably, based on the total weight of the compound solution for wet wipes, the weight percentage of the organic acid salt preservative is 0.05%-0.3%, the weight percentage of the biguanide polymer preservative is 0.01%-0.2%, the weight percentage of the phenolic ether preservative is 0.01%-0.2%, and the weight percentage of the antistatic agent is 0.005%-0.1%.

[0008] Preferably, based on the total weight of the compound solution for wet wipes, the weight percentage of the long-lasting cooling agent is 0.05%-1.0%, and the weight percentage of the instant cooling agent is 0.01%-0.5%.

[0009] Preferably, the zinc salt astringent includes zinc aromatic sulfonate, the polyhydroxy lactone pH buffer includes aldonic acid lactone, and the chelating agent is disodium EDTA. The aromatic zinc sulfonate is zinc phenol sulfonate, and the aldonic acid lactone is gluconic acid lactone; Based on the total weight of the compound solution for wet wipes, the weight percentage of zinc phenolsulfonate is 0.05%-0.15%, the weight percentage of gluconolactone is 0.05%-0.15%, and the weight percentage of disodium EDTA is 0.01%-0.1%. The mass ratio of zinc phenolsulfonate to gluconolactone is 1:(0.8-1.2).

[0010] Preferably, the organic acid salt preservative includes sodium benzoate, the phenolic ether preservative includes phenoxyethanol, the biguanide polymer preservative includes polyurethane-propyl biguanide, and the antistatic agent includes laurylpyridinium chloride and cetylpyridinium chloride; Based on the total weight of the compound solution for wet wipes, the weight percentage of sodium benzoate is 0.05%-0.15%, the weight percentage of phenoxyethanol is 0.01%-0.1%, the weight percentage of polyaminopropyl biguanide is 0.03%-0.1%, the weight percentage of laurylpyridinium chloride is 0.01%-0.06%, and the weight percentage of cetylpyridinium chloride is 0.01%-0.05%.

[0011] Preferably, the long-lasting cooling agent includes methyl diisopropyl propionamide, and the instant cooling agent includes menthol; Based on the total weight of the compound solution for wet wipes, the weight percentage of methyl diisopropyl propionamide is 0.1%-0.3%, and the weight percentage of menthol is 0.05%-0.15%. The mass ratio of methyl diisopropylpropionamide to menthol is (1.5-2.5):1.

[0012] Preferably, the pH value of the compound solution for wet wipes is 4.0-6.0; the polyol includes glycerol, and the alcohol-containing aqueous solvent includes water and ethanol; Based on the total weight of the compound solution for wet wipes, the weight percentage of ethanol is 5.0%-15.0%, the weight percentage of water is 85.0%-95.0%, and the weight percentage of glycerin is 0.1%-1%.

[0013] A method for preparing a long-lasting cooling wipe compound solution includes: Provide the alcohol-containing aqueous solvent; The cooling component, the conditioning and stabilizing composition, and the composite antiseptic and antibacterial system are added to the alcohol-containing aqueous solvent for mixing and dissolution to obtain a multi-effect compatible system. Adjust the pH value of the multi-effect compatible system to obtain a compound solution for wet wipes.

[0014] Preferably, the mixing and dissolving includes: The zinc salt astringent, the chelating agent, and the polyhydroxy lactone pH buffer are added to the aqueous phase of the alcohol-containing aqueous solvent and stirred to dissolve, thereby obtaining a first mixture. Add the moisturizer to the first mixture; The long-lasting cooling agent and the instant cooling agent are pre-dissolved in the ethanol phase of the alcohol-containing aqueous solvent to obtain a pre-dissolved cooling liquid; The pre-dissolved cooling liquid is added to the first mixture and mixed. Add the organic acid salt preservative, the phenolic ether preservative, the biguanide polymer preservative, and the antistatic agent; stir until homogeneous at a temperature of 20-35°C.

[0015] Beneficial Effects: The compound solution for wet wipes provided in this application innovatively introduces a conditioning and stabilizing composition consisting of zinc salt astringents and polyhydroxyl lactone pH buffers into an alcohol-containing aqueous solvent. Utilizing the dynamic hydrolysis buffering mechanism of polyhydroxyl lactones and the complexation stabilizing effect of zinc salts, it effectively overcomes the compatibility problem of the composite antiseptic and antibacterial system (organic acid salts, biguanides, antistatic agents) caused by changes in the dielectric constant of the alcohol-containing system, preventing turbidity, precipitation, and pH drift. This compound solution maintains the cooling and penetration-enhancing advantages of ethanol while achieving long-term stable coexistence of the cooling components and multiple antiseptic systems. The pH value is stably maintained within the suitable slightly acidic range for the skin, exhibiting excellent physicochemical stability, broad-spectrum antibacterial efficacy, and a comfortable cooling experience, meeting the stringent requirements of multi-effect compatibility and high-quality stability for alcohol-containing cooling wet wipes. Detailed Implementation

[0016] The following description is merely a preferred embodiment of the present invention, and the scope of protection is not limited to this embodiment. All technical solutions falling within the scope of the present invention should be considered within the protection scope of the present invention. It should also be noted that for those skilled in the art, any improvements and modifications made without departing from the principles of the present invention should also be considered within the protection scope of the present invention.

[0017] Example 1

[0018] This embodiment provides a long-lasting cooling wipe compound solution, which consists of cooling components, moisturizers, conditioning and stabilizing compositions, a complex antiseptic and antibacterial system, and an alcohol-containing aqueous solvent. Each functional component is dispersed in the alcohol-containing aqueous solvent to form a multi-functional and compatible system. The alcohol-containing aqueous solvent, serving as the dispersion medium for each functional component, includes water and ethanol. Based on the total weight of the compound solution, the amount of water is 89.45%, and the amount of ethanol is 9.24%. The introduction of ethanol helps to increase the evaporation rate of the cooling components on the skin surface, enhancing the instantaneous cooling sensation, while also promoting the penetration of active ingredients into the stratum corneum of the skin and exerting an auxiliary antibacterial effect.

[0019] It should be understood that the amount of ethanol used is not limited to the specific value in this embodiment. In other embodiments, the weight percentage of ethanol can be adjusted in the range of 5.0%-15.0%, and the weight percentage of water can be adjusted in the range of 85.0%-95.0%.

[0020] The cooling components include a long-lasting cooling agent and an instantaneous cooling agent. In this embodiment, the long-lasting cooling agent is methyl diisopropyl propionamide, used at 0.2%; the instantaneous cooling agent is menthol, used at 0.1%. The mass ratio of methyl diisopropyl propionamide to menthol is 2:1. Methyl diisopropyl propionamide is a non-menthol-based long-lasting cooling agent that generates a cooling signal by activating the TRPM8 channel, a cold-sensing receptor in the skin. Due to its lack of the high volatility of menthol, it can maintain a continuous cooling sensation on the skin surface for a longer period. Menthol, as an instantaneous cooling agent, has rapid evaporation characteristics and can produce a strong cooling sensation upon wiping. When used in combination, menthol provides an immediate cooling impact, while methyl diisopropyl propionamide continues to activate cold-sensing receptors after menthol evaporates, thus achieving a transition from instantaneous to long-lasting cooling.

[0021] It should be understood that the dosage of long-acting cooling agent can be adjusted within the range of 0.05%-1.0%, the dosage of instant cooling agent can be adjusted within the range of 0.01%-0.5%, and the mass ratio of the two can be adjusted within the range of (1.5-2.5):1.

[0022] The moisturizer is glycerin, used at a concentration of 0.5%. As a polyol moisturizer, glycerin can form a moisturizing film on the skin surface after wiping with a wet wipe, preventing excessive moisture loss from the skin during ethanol evaporation, thereby alleviating the dryness that may be caused by alcohol-containing systems.

[0023] It should be understood that the amount of glycerin used can be adjusted within the range of 0.1%-1%.

[0024] The conditioning and stabilizing composition includes a zinc salt astringent, a chelating agent, and a polyhydroxyl lactone pH buffer. In this embodiment, the zinc salt astringent is zinc phenolsulfonate, used at 0.1%; the polyhydroxyl lactone pH buffer is gluconolactone, used at 0.1%; and the chelating agent is disodium EDTA, used at 0.05%. The mass ratio of zinc phenolsulfonate to gluconolactone is 1:1.

[0025] Gluconolactone is a polyhydroxy lactone compound that undergoes slow, dynamic hydrolysis in aqueous systems, gradually releasing gluconic acid and thus establishing a sustained acid-base buffering capacity. This dynamic hydrolysis buffering mechanism allows the system to automatically replenish acidic substances through the ring-opening hydrolysis reaction of the lactone when subjected to external acid-base disturbances, maintaining the pH value stably within a weakly acidic range. Zinc phenolsulfonate acts as an astringent, providing a mild astringent effect on the skin when wiped with a wet wipe. Furthermore, zinc ions can complex with free anions in the system, preventing antagonistic precipitation of anions against cationic preservatives. Disodium EDTA, as a chelating agent, preferentially complexes trace metal ions in the system, preventing discoloration or degradation caused by metal ion-catalyzed oxidation reactions. These three components work synergistically to maintain the pH stability and component compatibility of the system.

[0026] The dosage of zinc salt astringent can be adjusted within the range of 0.05%-0.3%, the dosage of polyhydroxy lactone pH buffer can be adjusted within the range of 0.05%-0.3%, and the dosage of chelating agent can be adjusted within the range of 0.01%-0.2%.

[0027] The composite preservative and antibacterial system comprises organic acid salt preservatives, biguanide polymer preservatives, phenolic ether preservatives, and antistatic agents. In this embodiment, the organic acid salt preservative is sodium benzoate, used at 0.1%; the biguanide polymer preservative is polyaminopropyl biguanide, used at 0.06%; the phenolic ether preservative is phenoxyethanol, used at 0.05%; and the antistatic agents include laurylpyridinium chloride and cetylpyridinium chloride, used at 0.03% and 0.02%, respectively. This composite preservative and antibacterial system achieves broad-spectrum antibacterial activity through a multi-target synergistic mechanism.

[0028] Sodium benzoate transforms into benzoic acid under acidic conditions, which can penetrate microbial cell membranes and inhibit intracellular enzyme activity. Polyaminopropyl biguanide, as a cationic polymer, binds to the negatively charged microbial cell membrane through electrostatic adsorption, disrupting membrane integrity. Phenoxyethanol achieves bactericidal effects by dissolving the lipid layer of microbial cell membranes. Laurylpyridinium chloride and cetylpyridinium chloride, as cationic surfactants, not only possess antistatic properties but also enhance their antibacterial effect through the interaction of their positive charges with the negative charges of microbial cell membranes. The combined use of multiple preservatives enables the system to inhibit various microorganisms, including Gram-positive bacteria, Gram-negative bacteria, and fungi, while reducing the risk of skin irritation that may result from excessive use of a single preservative.

[0029] The dosage of organic acid salt preservatives can be adjusted within the range of 0.05%-0.3%, the dosage of biguanide polymer preservatives can be adjusted within the range of 0.01%-0.2%, the dosage of phenolic ether preservatives can be adjusted within the range of 0.01%-0.2%, and the dosage of antistatic agents can be adjusted within the range of 0.005%-0.1%. The pH value of the compound solution in this embodiment is 5.0, which is in the weakly acidic range and close to the natural pH value of human skin, thus helping to maintain the skin barrier function. It should be understood that the pH value of the compound solution can be adjusted within the range of 4.0-6.0.

[0030] Example 2 differs from Example 1 in that the proportions of each component are different.

[0031] Based on the total weight of the compound solution, the formulation of this embodiment is as follows: water 91.17%, ethanol 7.5%, glycerin 0.3%, methyl diisopropyl propionamide 0.3%, menthol 0.12%, zinc phenolsulfonate 0.15%, gluconolactone 0.12%, disodium EDTA 0.1%, sodium benzoate 0.05%, polyurethane biguanide 0.03%, phenoxyethanol 0.01%, laurylpyridine azinon chloride 0.06%, and cetylpyridinium chloride 0.05%.

[0032] In this embodiment, the mass ratio of methyl diisopropylpropionamide to menthol is 2.5:1, which is at the upper limit of this range, focusing on enhancing the duration of the cooling sensation. The mass ratio of zinc phenolsulfonate to gluconolactone is 1.25:1, with a relatively high amount of zinc salt astringent, which is beneficial for enhancing the astringent effect and complexing stability. The ethanol content is 7.5%, which is relatively low and suitable for skin types sensitive to ethanol. The pH of the compound solution is 4.5.

[0033] Example 3 differs from Example 1 in that the proportions of each component are different, in order to further demonstrate the applicability of the formulation system of the present invention.

[0034] Based on the total weight of the compound solution, the formulation of this embodiment is as follows: ethanol 12.0%, glycerol 0.8%, methyl diisopropyl propionamide 0.1%, menthol 0.05%, zinc phenolsulfonate 0.05%, gluconolactone 0.05%, disodium EDTA 0.01%, sodium benzoate 0.15%, polyurethane biguanide 0.1%, phenoxyethanol 0.1%, laurylpyridine azinon chloride 0.01%, cetylpyridinium chloride 0.01%, and the remaining amount of the compound solution is made up to 100% with water.

[0035] In this embodiment, the mass ratio of methyl diisopropylpropionamide to menthol is 2:1, resulting in a relatively low total amount of cooling agent, suitable for applications where a lower intensity of cooling is required but gentleness is emphasized. The ethanol content is 12.0%, which is relatively high, providing a more significant refreshing sensation and quick-drying properties, suitable for post-exercise cleansing. The mass ratio of zinc phenolsulfonate to gluconolactone is 1:1. The relatively high amounts of each component in the preservative and antibacterial components are used to meet the stability requirements of the system at higher ethanol contents. The pH of the compound solution is 5.5.

[0036] Example 4 This example provides a method for preparing the long-lasting cooling wipe compound solution described in any one of Examples 1 to 3 above: The specific steps are as follows: Step 1, prepare an alcohol-containing aqueous solvent. Mix the prescribed amount of ethanol with some water to prepare an alcohol-containing aqueous solvent.

[0037] Step two: Add the prescribed amounts of zinc phenolsulfonate, disodium EDTA, and gluconolactone to the aqueous phase containing an alcohol-based solvent, and stir until completely dissolved to obtain the first mixture. In this step, the conditioning and stabilizing components preferentially dissolve in the aqueous phase, establishing an initial buffer and chelating environment, providing stable acid-base conditions for the subsequently added preservative and antibacterial components.

[0038] Step 3: Add the prescribed amount of glycerin to the first mixture and stir well.

[0039] Step four: Dissolve the prescribed amounts of methyl diisopropylpropionamide and menthol in the ethanol phase to obtain a pre-dissolved cooling solution. Since the cooling agent is more soluble in ethanol than in water, pre-dissolving it in the ethanol phase ensures that the cooling agent is fully dispersed, avoiding localized supersaturation or precipitation during subsequent mixing.

[0040] Step 5: Add the pre-dissolved cooling liquid to the first mixture and stir until well mixed.

[0041] Step Six: Add the formulated amounts of sodium benzoate, phenoxyethanol, polyaminopropyl biguanide, laurylpyridinium chloride, and cetylpyridinium chloride sequentially. Stir at 25°C until the system is homogeneous and transparent to obtain the long-lasting cooling wipes compound solution. Through the above stepwise dissolution process, the conditioning and stabilizing composition is first fully dissolved in the aqueous phase to establish a buffer system. Then, the cooling component is pre-dissolved in the ethanol phase before being added. Finally, the preservative and antibacterial components are added. This effectively avoids direct collisions and antagonistic reactions between the components in a high-concentration ethanol environment, ensuring the clarity, transparency, and long-term stability of the final product.

[0042] It should be understood that the stirring temperature can be adjusted within the range of 20-35℃, and the order of adding materials in each step can be adjusted appropriately according to the actual production conditions, as long as the components are fully dissolved and the system is homogeneous.

[0043] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in the present invention should be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. A long-lasting cooling wipe compound solution, characterized in that, include: Cooling components, wherein the cooling components include long-lasting cooling agents and instant cooling agents; Moisturizers, including polyols; A conditioning and stabilizing composition comprising a zinc salt astringent, a chelating agent, and a polyhydroxy lactone pH buffer, for buffering the acidity and alkalinity of the system and maintaining component compatibility; A composite preservative and antibacterial system, comprising organic acid salt preservatives, biguanide polymer preservatives, phenolic ether preservatives, and antistatic agents, for providing broad-spectrum antibacterial effects; And an alcohol-containing aqueous solvent, which serves as the dispersion medium for the cooling component, the conditioning and stabilizing composition, and the composite antiseptic and antibacterial system; The conditioning and stabilizing composition, the composite antiseptic and antibacterial system, and the cooling component form a multi-functional and compatible system in the alcohol-containing aqueous solvent.

2. The long-lasting cooling wipe compound solution according to claim 1, characterized in that, Based on the total weight of the compound solution for wet wipes, the zinc salt astringent has a weight percentage of 0.05%-0.3%, the polyhydroxy lactone pH buffer has a weight percentage of 0.05%-0.3%, and the chelating agent has a weight percentage of 0.01%-0.2%.

3. The long-lasting cooling wipe compound solution according to claim 1, characterized in that, Based on the total weight of the compound solution for wet wipes, the weight percentage of the organic acid salt preservative is 0.05%-0.3%, the weight percentage of the biguanide polymer preservative is 0.01%-0.2%, the weight percentage of the phenolic ether preservative is 0.01%-0.2%, and the weight percentage of the antistatic agent is 0.005%-0.1%.

4. The long-lasting cooling wipe compound solution according to claim 1, characterized in that, Based on the total weight of the compound solution for wet wipes, the weight percentage of the long-lasting cooling agent is 0.05%-1.0%, and the weight percentage of the instant cooling agent is 0.01%-0.5%.

5. The long-lasting cooling wipe compound solution according to claim 2, characterized in that, The zinc salt astringent includes aromatic zinc sulfonate, the polyhydroxy lactone pH buffer includes aldonic acid lactone, and the chelating agent is disodium EDTA. The aromatic zinc sulfonate is zinc phenol sulfonate, and the aldonic acid lactone is gluconic acid lactone; Based on the total weight of the compound solution for wet wipes, the weight percentage of zinc phenolsulfonate is 0.05%-0.15%, the weight percentage of gluconolactone is 0.05%-0.15%, and the weight percentage of disodium EDTA is 0.01%-0.1%. The mass ratio of zinc phenolsulfonate to gluconolactone is 1:(0.8-1.2).

6. The long-lasting cooling wipe compound solution according to claim 3, characterized in that, The organic acid salt preservative includes sodium benzoate, the phenolic ether preservative includes phenoxyethanol, the biguanide polymer preservative includes polyurethane biguanide, and the antistatic agent includes laurylpyridinium chloride and cetylpyridinium chloride; Based on the total weight of the compound solution for wet wipes, the weight percentage of sodium benzoate is 0.05%-0.15%, the weight percentage of phenoxyethanol is 0.01%-0.1%, the weight percentage of polyaminopropyl biguanide is 0.03%-0.1%, the weight percentage of laurylpyridinium chloride is 0.01%-0.06%, and the weight percentage of cetylpyridinium chloride is 0.01%-0.05%.

7. The long-lasting cooling wipe compound solution according to claim 4, characterized in that, The long-lasting cooling agent includes methyl diisopropyl propionamide, and the instant cooling agent includes menthol; Based on the total weight of the compound solution for wet wipes, the weight percentage of methyl diisopropyl propionamide is 0.1%-0.3%, and the weight percentage of menthol is 0.05%-0.15%. The mass ratio of methyl diisopropylpropionamide to menthol is (1.5-2.5):

1.

8. The long-lasting cooling wipe compound solution according to claim 1, characterized in that, The pH value of the compound solution for wet wipes is 4.0-6.0; the polyol includes glycerol, and the alcohol-containing aqueous solvent includes water and ethanol; Based on the total weight of the compound solution for wet wipes, the weight percentage of ethanol is 5.0%-15.0%, the weight percentage of water is 85.0%-95.0%, and the weight percentage of glycerin is 0.1%-1%.

9. A method for preparing a long-lasting cooling wipe compound solution according to any one of claims 1-8, characterized in that, include: Provide the alcohol-containing aqueous solvent; The cooling component, the conditioning and stabilizing composition, and the composite antiseptic and antibacterial system are added to the alcohol-containing aqueous solvent for mixing and dissolution to obtain a multi-effect compatible system. Adjust the pH value of the multi-effect compatible system to obtain a compound solution for wet wipes.

10. The method for preparing a long-lasting cooling wipe compound solution according to claim 9, characterized in that, The mixed dissolution includes: The zinc salt astringent, the chelating agent, and the polyhydroxy lactone pH buffer are added to the aqueous phase of the alcohol-containing aqueous solvent and stirred to dissolve, thereby obtaining a first mixture. Add the moisturizer to the first mixture; The long-lasting cooling agent and the instant cooling agent are pre-dissolved in the ethanol phase containing the alcohol-aqueous solvent to obtain a pre-dissolved cooling liquid; The pre-dissolved cooling liquid is added to the first mixture and mixed. Add the organic acid salt preservative, phenolic ether preservative, biguanide polymer preservative and antistatic agent; stir until homogeneous at 20-35°C.