Full-automatic mobile phase liquid preparation device

Abstract

The utility model discloses a full-automatic mobile phase liquid preparation device which comprises a cabinet, a plurality of kits, a liquid preparation assembly, a code scanner, a control system and a turntable assembly, the turntable assembly is arranged at the lower end part of the cabinet, and a plurality of bases for placing mobile phase bottles are distributed on a turntable of the turntable assembly along the circumference; a label positioning block used for positioning a bar code is arranged on each base, a liquid outlet of the liquid preparation assembly is arranged right above a liquid preparation station of the turntable, and the code scanner is arranged on one side of the turntable of the turntable assembly and right faces the label positioning block; and a motor of the turntable assembly is electrically connected with the control system. The system is simple in structure and high in automatic identification intelligence degree, and reduces the cost.

Description

Technical Field

[0001] The utility model belongs to liquid preparation technology, and specifically relates to a full-automatic mobile phase liquid preparation device. Background Art

[0002] In the process of industrial preparation chromatography, the mobile phase preparation method is usually adopted. Although the existing automatic preparation platform is equipped with a barcode scanner to automatically scan the barcode and read the information for preparation, it still requires manual operation of the barcode scanner and manual supervision to promptly observe whether the pipeline is lacking liquid or blocked, thus failing to achieve truly fully automated operation.

[0003] Therefore, there is an urgent need to provide a mobile phase configuration device with a high degree of automation. Summary of the invention

[0004] The utility model aims to provide a fully automatic mobile phase liquid matching device in view of the deficiencies in the prior art. The device has a simple structure, a high degree of automation, can realize multi-function automatic switching, reduces the footprint of the device, and reduces costs.

[0005] The technical solution adopted by the purpose of the utility model is:

[0006] A fully automatic mobile phase liquid preparation device comprises a plurality of test kits, a liquid preparation assembly, a barcode scanner and a control system, wherein the liquid preparation assembly is connected to each of the test kits through a conveying pipeline, and the liquid preparation assembly and the barcode scanner are electrically connected to the control system respectively. The device also comprises a cabinet, wherein the plurality of test kits, the liquid preparation assembly, the barcode scanner and the control system are all arranged in the cabinet, and a turntable assembly is also arranged in the cabinet, wherein the turntable assembly is arranged at the lower end of the cabinet, and a plurality of bases for placing mobile phase bottles are distributed along the circumference of the turntable of the turntable assembly, and each of the bases is provided with a label positioning block for positioning a barcode, and a liquid outlet of the liquid preparation assembly is arranged directly above the liquid preparation station of the turntable, and the barcode scanner is arranged on one side of the turntable of the turntable assembly, facing the label positioning block; and a motor of the turntable assembly is electrically connected to the control system.

[0007] Furthermore, the base is a groove structure, a positioning groove is provided on the base, the label positioning block is a clamp for being mounted on the mobile phase bottle, a protrusion movably matched with the positioning groove of the base is provided at the lower end of the clamp, and a barcode positioning hole is provided on the clamp.

[0008] Furthermore, the clamp is an arc block, and springs are connected to both ends of the arc block to form a clamp structure.

[0009] Furthermore, the control system includes an operation panel, an emergency stop button, a pause button, a start button, a confirmation button and a controller, the operation panel, the start button, the emergency stop button, the pause button and the confirmation button are electrically connected to the controller respectively, the emergency stop button is set on the cabinet, and the start button, the pause button and the confirmation button are set next to the operation panel.

[0010] Furthermore, the liquid preparation assembly includes a peristaltic pump and a plunger pump, the peristaltic pump and the plunger pump are respectively connected to each test kit through a delivery pipe, the peristaltic pump is used to deliver a large flow of reagents, and the plunger pump is used to deliver a small flow of reagents. The peristaltic pump and the plunger pump are respectively electrically connected to the control system, and the control system is used to control the actions of the peristaltic pump and the plunger pump according to the barcode information obtained by the scanner.

[0011] Furthermore, it also includes a printer, which is a thermal printer. The printer is arranged in the cabinet, and the printer is electrically connected to the control system for printing the information input on the operation panel.

[0012] Furthermore, an infusion alarm and an alarm light are provided. The alarm light adopts a three-color alarm light. A bubble sensor is provided on each of the delivery pipelines. The bubble sensor, the infusion alarm and the alarm light are electrically connected to the control system respectively. The bubble sensor is used to detect whether the delivery pipeline is short of liquid, has bubbles, or is detached or blocked. When the bubble sensor detects that the infusion is abnormal, an alarm is issued through the infusion alarm and the three-color alarm light.

[0013] Furthermore, it also includes an exhaust assembly, which is arranged on the upper end surface of the cabinet and is electrically connected to the control system to extract the odor emitted by the liquid during liquid preparation.

[0014] The above technical solution has the following beneficial effects:

[0015] The utility model has a simple structure, utilizes a turntable assembly to place multiple mobile phase bottles, utilizes a label positioning block to stick a barcode, facilitates a barcode scanner to align with the barcode on the label positioning block for automatic identification and sends the contained information to a control system, and the control system controls the liquid preparation assembly to prepare the liquid. After the current mobile phase bottle is configured, the rotating turntable automatically rotates to send the mobile phase bottle to be prepared to the liquid preparation station for preparation. The loading and liquid preparation operations of the utility model are all automated operations, without manual operation, and have a high degree of automation.

[0016] The base is provided with a positioning groove, the label positioning block adopts a clamp, the clamp is provided with a protrusion that movably cooperates with the positioning groove of the base, the clamp is provided with a barcode positioning hole, and the label positioning block can be freely taken and placed on the base to avoid blocking and affecting the taking and placing of the mobile phase bottle.

[0017] The clamp adopts an arc block, and springs are connected at both ends of the arc block to form a clamp structure, which is not only convenient for sleeve installation on the mobile phase bottle, but also can be used for mobile phase bottles of different diameters, and has a wider range of uses.

[0018] It also includes an infusion alarm and an alarm light. The alarm light adopts a three-color alarm light. A bubble sensor is also provided on the delivery pipeline. When the bubble sensor detects that the delivery pipeline is short of liquid, has bubbles, the pipeline is detached, or is blocked, the infusion alarm and the three-color alarm light will alarm without manual fixed guard.

[0019] An exhaust assembly is added to exhaust the odors brought by reagents during work, ensuring a good working and experimental environment.

[0020] The printer is set on the cabinet, and information is directly inputted through the operation panel of the control system, and then it is printed out on the cabinet. It integrates printing and code scanning to achieve fully automatic integrated operation.

[0021] The liquid preparation assembly includes a peristaltic pump and a plunger pump, which are respectively connected to each reagent box through a delivery pipeline. The peristaltic pump is used to deliver a large flow reagent, and the plunger pump is used to deliver a small flow reagent, which not only makes the flow control more precise but also improves the work efficiency.

[0022] Further description is given below in conjunction with the accompanying drawings and specific implementation methods. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is a structural schematic diagram of specific embodiment 1;

[0024] Figure 2 for Figure 1 A front view of

[0025] Figure 3 for Figure 1 Rear view of.

[0026] In the accompanying drawings, 1 is a cabinet, 2 is a reagent box, 3 is a liquid preparation assembly, 3-1 is a peristaltic pump, 3-2 is a plunger pump, 4 is a barcode scanner, 5 is a printer, 6 is a turntable assembly, 6-1 is a base, 6-2 is a positioning slot, 6-3 is a label positioning block, 6-4 is a cleaning slot, 6-5 is a barcode positioning hole, 6-6 is a turntable, 8 is a controller, 8-1 is an operation panel, 8-2 is an emergency stop button, 11 is an infusion alarm, 12 is an alarm light, 13 is a mobile phase bottle, and 14 is an exhaust assembly. DETAILED DESCRIPTION Specific embodiment 1:

[0028] See also Figures 1 to 3As shown, a fully automatic mobile phase liquid preparation device includes a cabinet 1, multiple reagent kits 2, a liquid preparation assembly 3, a barcode scanner 4, a printer 5, a turntable assembly 6, and a control system. The multiple reagent kits 2, the liquid preparation assembly 3, the barcode scanner 4, the turntable assembly 6, the printer 5 and the control system are all arranged in the cabinet 1. The cabinet 1 is a rectangular frame, and the rectangular frame is provided with at least a bottom plate and a back plate. The liquid preparation assembly 3 is connected to each of the reagent kits 2 through a conveying pipeline. The turntable assembly 6 is arranged at the lower end of the cabinet 1. The turntable assembly 6 includes a turntable 6-6 and a motor for driving the turntable to rotate. The turntable 6-6 is arranged on the bottom plate of the cabinet 1. The turntable of the turntable assembly 6 has six A base 6-1 for placing a mobile phase bottle 13, the mobile phase bottle 13 is used when used for mobile phase preparation, and is used when used for pH modulation. The base 6-1 is in a groove structure, and each base 6-1 is provided with a label positioning block 6-3 for positioning a barcode. A positioning groove 6-2 is provided on the base 6-1, and the label positioning block 6-3 is a clamp for being set on the mobile phase bottle. A protrusion that movably cooperates with the positioning groove of the base 6-1 is provided on the lower end of the clamp, and a barcode positioning hole 6-5 is provided on the clamp. In this specific embodiment: the clamp adopts an arc block, the arc block is a superior arc structure, and two springs are connected to both ends of the arc block to form a clamp structure. A cleaning tank 6-4 for cleaning the pH probe and the stirring paddle is also provided in the center of the turntable of the turntable assembly 6. A liquid inlet is provided on the side wall of the cleaning tank 6-4, and a liquid outlet is provided at the bottom of the cleaning tank 6-4. The liquid inlet is connected to a cleaning peristaltic pump through a pipeline. The cleaning peristaltic pump is provided at the lower end surface of the bottom of the cabinet 1, and the cleaning peristaltic pump is connected to the cleaning liquid. The liquid inlet is provided with a liquid inlet valve, the liquid outlet is provided with a waste liquid valve, and the liquid outlet is connected to a waste liquid collection container through a waste liquid pipe.

[0029] The liquid outlet of the liquid dispensing assembly 3 is arranged just above the liquid dispensing station of the turntable, and the barcode scanner 4 is arranged on one side of the turntable of the turntable assembly 6, facing the label positioning block, so as to facilitate rapid positioning and automatic scanning. The liquid dispensing assembly 3 and the barcode scanner 4 are electrically connected to the control system respectively, and the barcode scanner 4 is used to scan the barcode and upload it to the control system. The control system includes an operation panel 8-1, an emergency stop button, a pause button, a start button, a confirmation button and a controller 8. The operation panel, the start button, the emergency stop button 8-2, the pause button and the confirmation button are electrically connected to the controller 8 respectively. The operation panel 8-1, the start button, the pause button and the confirmation button are arranged just above the cabinet and beside the operation panel, the emergency stop button 8-2 is arranged on the bottom plate at the lower end of the cabinet, the controller 8 is arranged on the back plate of the cabinet 1, the emergency stop button is arranged on the cabinet 1, and the start button, the pause button and the confirmation button are arranged beside the operation panel. Each button is convenient for starting the corresponding program of each button according to the actual operation situation. The printer 5 is a thermal printer 5, which is arranged next to the operation panel of the control system, just above the pause button and the confirmation button. The printer 5 is electrically connected to the control system to print out the information input on the operation panel and output a barcode.

[0030] The liquid preparation assembly 3 includes a peristaltic pump 3-1 and a plunger pump 3-2, and the peristaltic pump 3-1 and the plunger pump 3-2 are respectively connected to each reagent kit 2 through a delivery pipeline. The peristaltic pump 3-1 is used to transport a large flow of reagents, and the plunger pump 3-2 is used to transport a small flow of reagents. The driving units of the peristaltic pump 3-1 and the plunger pump 3-2 are respectively electrically connected to the control system, and the control system is used to control the pumping actions of the peristaltic pump 3-1 and the plunger 3-2, and rotate the peristaltic pump 3-1 and the plunger pump 3-2 to deliver the corresponding reagents according to the liquid preparation quantity requirements.

[0031] Possibly, an infusion alarm 11 and an alarm light 12 are also provided. The alarm light 12 is a three-color alarm light. Each delivery pipeline is provided with a bubble sensor. The bubble sensor, the infusion alarm 11 and the alarm light 12 are electrically connected to the control system respectively. The bubble sensor is used to detect whether the delivery pipeline is short of liquid, bubbles, pipeline detachment, or blockage. When the bubble sensor 13 detects abnormal infusion, the infusion alarm 11 and the three-color alarm light are used to alarm, without manual duty, thereby reducing the manual workload.

[0032] Possibly, an exhaust assembly 14 is also included, and the exhaust assembly 14 uses an exhaust fan. The exhaust assembly 14 is arranged on the upper end surface of the cabinet 1. The exhaust fan of the exhaust assembly 14 is electrically connected to the control system and is used to extract the odor emitted by the liquid during liquid preparation. An exhaust duct is provided at the upper end of the exhaust assembly, which extends to a waste treatment duct through the exhaust duct.

[0033] See also Figure 2 As shown, the working principle of the utility model is:

[0034] The utility model enters the liquid preparation stage,

[0035] Step 1: Enter the recipe and preparation quantity information on the operation panel 8-1, the quantity is 1-5, and press the panel confirmation key to start the device;

[0036] Step 2: The printer starts printing the label barcode according to the information entered in step 1;

[0037] Step 3: Stick the label barcode to the barcode positioning hole 6-5 of the bottle clamp and put it into the turntable.

[0038] Step 4: Press the Pause button, go to the next station and put in the second mobile phase bottle 13. After putting in all the bottles, press the Confirm button again to start the liquid preparation program.

[0039] Step 5: The mobile phase bottle 13 automatically moves to the liquid preparation station, and the barcode scanner 4 scans the barcode. The barcode on the label positioning block is automatically identified and transmitted to the control system by the barcode scanner, so that the control system automatically controls the liquid preparation assembly 3 to prepare the liquid according to the information contained in the acquired barcode; if the code is not scanned, the machine will stop and alarm, and the emergency stop button will be activated to manually adjust the bottle. After the code is scanned, the alarm is lifted and the liquid preparation continues.

[0040] Step 6: Add liquids according to the recipe in the order of adding small flow liquid first and then adding large flow liquid.

[0041] Step 7: During the liquid adding process, if the reagent sensor finds that a certain delivery pipeline is short of liquid, the equipment will stop operating, record the added volume, and the three-color alarm light will turn red. The display will prompt the delivery pipeline short of liquid alarm. Manually replace the liquid, press the confirmation button on the panel to start again, the alarm will be lifted, and the liquid replenishment will continue according to the recorded information.

[0042] Step 8: After the liquid is added, the turntable moves to the next station, and the rotating turntable automatically sends the bottle to be mixed to the mixing station for mixing;

[0043] Step 9: Repeat steps 6 to 9 until the input quantity is completed.

[0044] Step 10: After preparation, the turntable returns to zero position;

[0045] When cleaning, the conveying pipeline is cleaned: put the corresponding liquid inlet of the conveying pipeline to be cleaned into the cleaning liquid, put the waste liquid bottle on the turntable, start the cleaning program, turn the turntable to the waste liquid bottle to the liquid preparation station, and start continuously adding liquid to the cleaned conveying pipeline. After completion, take out the liquid inlet of the conveying pipeline, empty the cleaning liquid in the conveying pipeline, put it into the corresponding reagent, and then clean the next conveying pipeline. Repeat this operation until the required cleaning of the conveying pipeline is completed.

Claims

1. A fully automatic mobile phase preparation device, comprising a plurality of reagent kits, a preparation assembly, a barcode scanner and a control system, wherein the preparation assembly is connected to each of the reagent kits through a delivery pipeline, and the preparation assembly and the barcode scanner are electrically connected to the control system respectively, characterized in that: It also includes a cabinet, in which a turntable assembly is provided, and the turntable assembly is arranged at the lower end of the cabinet. A plurality of bases for placing mobile phase bottles are distributed along the circumference of the turntable of the turntable assembly, and each of the bases is provided with a label positioning block for positioning a barcode. The liquid outlet of the liquid preparation assembly is arranged directly above the liquid preparation station of the turntable, and the barcode scanner is arranged on one side of the turntable of the turntable assembly, facing the label positioning block; the motor of the turntable assembly is electrically connected to the control system.

2. The fully automatic mobile phase preparation device according to claim 1, characterized in that: The base is in a groove structure, a positioning groove is provided on the base, the label positioning block is a clamp for being set on the mobile phase bottle, a protrusion movably matched with the positioning groove of the base is provided at the lower end of the clamp, and a barcode positioning hole is provided on the clamp.

3. The fully automatic mobile phase preparation device according to claim 2, characterized in that: The clamp adopts an arc block, and springs are connected at both ends of the arc block to form a clamp structure.

4. The fully automatic mobile phase preparation device according to claim 1, characterized in that: The control system comprises an operation panel, an emergency stop button, a pause button, a start button, a confirmation button and a controller, and the operation panel, the start button, the emergency stop button, the pause button and the confirmation button are electrically connected to the controller respectively.

5. The fully automatic mobile phase preparation device according to claim 1 or 4, characterized in that: The liquid preparation assembly comprises a peristaltic pump and a plunger pump, the peristaltic pump and the plunger pump are respectively connected to each reagent box through a delivery pipeline, and the peristaltic pump and the plunger pump are respectively electrically connected to the control system.

6. The fully automatic mobile phase preparation device according to claim 1 or 4, characterized in that: It also includes a printer, which is arranged in the cabinet and is electrically connected to the control system.

7. The fully automatic mobile phase preparation device according to claim 1 or 4, characterized in that: An infusion alarm and an alarm light are also provided, and each of the delivery pipelines is provided with a bubble sensor, and the bubble sensor, the infusion alarm and the alarm light are electrically connected to the control system respectively.

8. The fully automatic mobile phase preparation device according to claim 1 or 4, characterized in that: It also includes an exhaust assembly, which is arranged on the upper end surface of the cabinet and is electrically connected to the control system.

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